                               SEQUENCE LISTING

<110> PALLEON PHARMACEUTICALS INC.
 
<120> RECOMBINANT SIALIDASES WITH REDUCED PROTEASE SENSITIVITY, 
      SIALIDASE FUSION PROTEINS, AND METHODS OF USING THE SAME

<130> PAL-023WO

<140> PCT/US2021/040240
<141> 2021-07-02

<150> 63/134,411
<151> 2021-01-06

<150> 63/047,989
<151> 2020-07-03

<160> 349   

<170> PatentIn version 3.5

<210> 1
<211> 380
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 2
<211> 385
<212> PRT
<213> Mus musculus

<400> 2
Met Glu Asp Leu Arg Pro Met Ala Thr Cys Pro Val Leu Gln Lys Glu 
1               5                   10                  15      


Thr Leu Phe Arg Thr Gly Val His Ala Tyr Arg Ile Pro Ala Leu Leu 
            20                  25                  30          


Tyr Leu Lys Lys Gln Lys Thr Leu Leu Ala Phe Ala Glu Lys Arg Ala 
        35                  40                  45              


Ser Lys Thr Asp Glu His Ala Glu Leu Ile Val Leu Arg Arg Gly Ser 
    50                  55                  60                  


Tyr Asn Glu Ala Thr Asn Arg Val Lys Trp Gln Pro Glu Glu Val Val 
65                  70                  75                  80  


Thr Gln Ala Gln Leu Glu Gly His Arg Ser Met Asn Pro Cys Pro Leu 
                85                  90                  95      


Tyr Asp Lys Gln Thr Lys Thr Leu Phe Leu Phe Phe Ile Ala Val Pro 
            100                 105                 110         


Gly Arg Val Ser Glu His His Gln Leu His Thr Lys Val Asn Val Thr 
        115                 120                 125             


Arg Leu Cys Cys Val Ser Ser Thr Asp His Gly Arg Thr Trp Ser Pro 
    130                 135                 140                 


Ile Gln Asp Leu Thr Glu Thr Thr Ile Gly Ser Thr His Gln Glu Trp 
145                 150                 155                 160 


Ala Thr Phe Ala Val Gly Pro Gly His Cys Leu Gln Leu Arg Asn Pro 
                165                 170                 175     


Ala Gly Ser Leu Leu Val Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro 
            180                 185                 190         


Ala Gln Lys Pro Thr Pro Phe Ala Phe Cys Phe Ile Ser Leu Asp His 
        195                 200                 205             


Gly His Thr Trp Lys Leu Gly Asn Phe Val Ala Glu Asn Ser Leu Glu 
    210                 215                 220                 


Cys Gln Val Ala Glu Val Gly Thr Gly Ala Gln Arg Met Val Tyr Leu 
225                 230                 235                 240 


Asn Ala Arg Ser Phe Leu Gly Ala Arg Val Gln Ala Gln Ser Pro Asn 
                245                 250                 255     


Asp Gly Leu Asp Phe Gln Asp Asn Arg Val Val Ser Lys Leu Val Glu 
            260                 265                 270         


Pro Pro His Gly Cys His Gly Ser Val Val Ala Phe His Asn Pro Ile 
        275                 280                 285             


Ser Lys Pro His Ala Leu Asp Thr Trp Leu Leu Tyr Thr His Pro Thr 
    290                 295                 300                 


Asp Ser Arg Asn Arg Thr Asn Leu Gly Val Tyr Leu Asn Gln Met Pro 
305                 310                 315                 320 


Leu Asp Pro Thr Ala Trp Ser Glu Pro Thr Leu Leu Ala Met Gly Ile 
                325                 330                 335     


Cys Ala Tyr Ser Asp Leu Gln Asn Met Gly Gln Gly Pro Asp Gly Ser 
            340                 345                 350         


Pro Gln Phe Gly Cys Leu Tyr Glu Ser Gly Asn Tyr Glu Glu Ile Ile 
        355                 360                 365             


Phe Leu Ile Phe Thr Leu Lys Gln Ala Phe Pro Thr Val Phe Asp Ala 
    370                 375                 380                 


Gln 
385 


<210> 3
<211> 5
<212> PRT
<213> Mus musculus

<400> 3
Glu Asp Leu Arg Pro 
1               5   


<210> 4
<211> 6
<212> PRT
<213> Mus musculus

<400> 4
Met Glu Asp Leu Arg Pro 
1               5       


<210> 5
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 6
<211> 1143
<212> DNA
<213> Salmonella typhimurium

<400> 6
acagtggaaa agtccgtggt gttcaaggcc gagggcgagc acttcaccga ccagaaaggc       60

aataccatcg tcggctctgg cagcggcggc accaccaagt actttagaat ccccgccatg      120

tgcaccacca gcaagggcac cattgtggtg ttcgccgacg ccagacacaa caccgccagc      180

gatcagagct tcatcgatac cgctgccgcc agatctaccg atggcggcaa gacctggaac      240

aagaagatcg ccatctacaa cgaccgcgtg aacagcaagc tgagcagagt gatggaccct      300

acctgcatcg tggccaacat ccagggcaga gaaaccatcc tggtcatggt cggaaagtgg      360

aacaacaacg ataagacctg gggcgcctac agagacaagg cccctgatac cgattgggac      420

ctcgtgctgt acaagagcac cgatgacggc gtgaccttca gcaaggtgga aacaaacatc      480

cacgacatcg tgaccaagaa cggcaccatc tctgccatgc tcggcggcgt tggatctggc      540

ctgcaactga atgatggcaa gctggtgttc cccgtgcaga tggtccgaac aaagaatatc      600

accaccgtgc tgaataccag cttcatctac agcaccgacg gcatcacatg gtccctgcct      660

agcggctact gtgaaggctt tggcagcgag aacaacatca tcgagttcaa cgccagcctg      720

gtcaacaaca tccggaacag cggcctgcgg agaagcttcg agacaaagga cttcggaaag      780

acgtggaccg agtttcctcc aatggacaag aaggtggaca accggaacca cggcgtgcag      840

ggcagcacaa tcacaatccc tagcggcaac aaactggtgg ccgctcactc tagcgcccag      900

aacaagaaca acgactacac cagaagcgac atcagcctgt acgcccacaa cctgtacagc      960

ggcgaagtga agctgatcga cgacttctac cccaaagtgg gcaatgccag cggagccggc     1020

tacagctgtc tgagctaccg gaaaaatgtg gacaaagaaa ccctgtacgt ggtgtacgag     1080

gccaacggca gcatcgagtt tcaggacctg agcagacatc tgcccgtgat caagagctac     1140

aac                                                                   1143


<210> 7
<211> 364
<212> PRT
<213> Homo sapiens

<400> 7
Glu Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu 
1               5                   10                  15      


Leu Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile 
            20                  25                  30          


Pro Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu 
        35                  40                  45              


Ala Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu 
    50                  55                  60                  


Arg Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile 
65                  70                  75                  80  


Val Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val 
                85                  90                  95      


Ser Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala 
            100                 105                 110         


His Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys 
        115                 120                 125             


Asp Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile 
    130                 135                 140                 


Gly Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln 
145                 150                 155                 160 


Arg Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu 
                165                 170                 175     


Glu Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser 
            180                 185                 190         


Trp Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys 
        195                 200                 205             


Gln Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro 
    210                 215                 220                 


Asp Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys 
225                 230                 235                 240 


His Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg 
                245                 250                 255     


Pro Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala 
            260                 265                 270         


Ala Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro 
        275                 280                 285             


Ala His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser 
    290                 295                 300                 


Asn Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro 
305                 310                 315                 320 


Ser Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu 
                325                 330                 335     


Glu Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His 
            340                 345                 350         


Tyr Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val 
        355                 360                 


<210> 8
<211> 428
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg Gln 
1               5                   10                  15      


Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr Ile 
            20                  25                  30          


Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr Arg 
        35                  40                  45              


Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg Ile 
    50                  55                  60                  


Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala Thr 
65                  70                  75                  80  


Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln Lys 
                85                  90                  95      


Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val Thr 
            100                 105                 110         


Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys Phe 
        115                 120                 125             


Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp Leu 
    130                 135                 140                 


Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe Ala 
145                 150                 155                 160 


Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val Ile 
                165                 170                 175     


Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln Leu 
            180                 185                 190         


Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp Leu 
        195                 200                 205             


Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr Val 
    210                 215                 220                 


Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val Leu 
225                 230                 235                 240 


Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu Ser 
                245                 250                 255     


Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln Leu 
            260                 265                 270         


Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg Pro 
        275                 280                 285             


Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala Pro 
    290                 295                 300                 


Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu Glu 
305                 310                 315                 320 


Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr Ser 
                325                 330                 335     


Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro Leu 
            340                 345                 350         


Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro Cys 
        355                 360                 365             


Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly Cys 
    370                 375                 380                 


Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe Arg 
385                 390                 395                 400 


Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys Thr 
                405                 410                 415     


Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn 
            420                 425             


<210> 9
<211> 461
<212> PRT
<213> Homo sapiens

<400> 9
Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
            20                  25                  30          


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
        35                  40                  45              


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
    50                  55                  60                  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
65                  70                  75                  80  


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
                85                  90                  95      


Ile Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala 
            100                 105                 110         


Thr Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln 
        115                 120                 125             


Lys Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val 
    130                 135                 140                 


Thr Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys 
145                 150                 155                 160 


Phe Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp 
                165                 170                 175     


Leu Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe 
            180                 185                 190         


Ala Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val 
        195                 200                 205             


Ile Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln 
    210                 215                 220                 


Leu Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp 
225                 230                 235                 240 


Leu Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr 
                245                 250                 255     


Val Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val 
            260                 265                 270         


Leu Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu 
        275                 280                 285             


Ser Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln 
    290                 295                 300                 


Leu Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg 
305                 310                 315                 320 


Pro Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala 
                325                 330                 335     


Pro Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu 
            340                 345                 350         


Glu Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
        355                 360                 365             


Ser Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
    370                 375                 380                 


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
385                 390                 395                 400 


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly 
                405                 410                 415     


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
            420                 425                 430         


Arg Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys 
        435                 440                 445             


Thr Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn 
    450                 455                 460     


<210> 10
<211> 484
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Val Pro Arg Thr Pro Ser Arg Thr Val Leu Phe Glu Arg Glu 
1               5                   10                  15      


Arg Thr Gly Leu Thr Tyr Arg Val Pro Ser Leu Leu Pro Val Pro Pro 
            20                  25                  30          


Gly Pro Thr Leu Leu Ala Phe Val Glu Gln Arg Leu Ser Pro Asp Asp 
        35                  40                  45              


Ser His Ala His Arg Leu Val Leu Arg Arg Gly Thr Leu Ala Gly Gly 
    50                  55                  60                  


Ser Val Arg Trp Gly Ala Leu His Val Leu Gly Thr Ala Ala Leu Ala 
65                  70                  75                  80  


Glu His Arg Ser Met Asn Pro Cys Pro Val His Asp Ala Gly Thr Gly 
                85                  90                  95      


Thr Val Phe Leu Phe Phe Ile Ala Val Leu Gly His Thr Pro Glu Ala 
            100                 105                 110         


Val Gln Ile Ala Thr Gly Arg Asn Ala Ala Arg Leu Cys Cys Val Ala 
        115                 120                 125             


Ser Arg Asp Ala Gly Leu Ser Trp Gly Ser Ala Arg Asp Leu Thr Glu 
    130                 135                 140                 


Glu Ala Ile Gly Gly Ala Val Gln Asp Trp Ala Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Gly Val Gln Leu Pro Ser Gly Arg Leu Leu Val Pro Ala 
                165                 170                 175     


Tyr Thr Tyr Arg Val Asp Arg Arg Glu Cys Phe Gly Lys Ile Cys Arg 
            180                 185                 190         


Thr Ser Pro His Ser Phe Ala Phe Tyr Ser Asp Asp His Gly Arg Thr 
        195                 200                 205             


Trp Arg Cys Gly Gly Leu Val Pro Asn Leu Arg Ser Gly Glu Cys Gln 
    210                 215                 220                 


Leu Ala Ala Val Asp Gly Gly Gln Ala Gly Ser Phe Leu Tyr Cys Asn 
225                 230                 235                 240 


Ala Arg Ser Pro Leu Gly Ser Arg Val Gln Ala Leu Ser Thr Asp Glu 
                245                 250                 255     


Gly Thr Ser Phe Leu Pro Ala Glu Arg Val Ala Ser Leu Pro Glu Thr 
            260                 265                 270         


Ala Trp Gly Cys Gln Gly Ser Ile Val Gly Phe Pro Ala Pro Ala Pro 
        275                 280                 285             


Asn Arg Pro Arg Asp Asp Ser Trp Ser Val Gly Pro Gly Ser Pro Leu 
    290                 295                 300                 


Gln Pro Pro Leu Leu Gly Pro Gly Val His Glu Pro Pro Glu Glu Ala 
305                 310                 315                 320 


Ala Val Asp Pro Arg Gly Gly Gln Val Pro Gly Gly Pro Phe Ser Arg 
                325                 330                 335     


Leu Gln Pro Arg Gly Asp Gly Pro Arg Gln Pro Gly Pro Arg Pro Gly 
            340                 345                 350         


Val Ser Gly Asp Val Gly Ser Trp Thr Leu Ala Leu Pro Met Pro Phe 
        355                 360                 365             


Ala Ala Pro Pro Gln Ser Pro Thr Trp Leu Leu Tyr Ser His Pro Val 
    370                 375                 380                 


Gly Arg Arg Ala Arg Leu His Met Gly Ile Arg Leu Ser Gln Ser Pro 
385                 390                 395                 400 


Leu Asp Pro Arg Ser Trp Thr Glu Pro Trp Val Ile Tyr Glu Gly Pro 
                405                 410                 415     


Ser Gly Tyr Ser Asp Leu Ala Ser Ile Gly Pro Ala Pro Glu Gly Gly 
            420                 425                 430         


Leu Val Phe Ala Cys Leu Tyr Glu Ser Gly Ala Arg Thr Ser Tyr Asp 
        435                 440                 445             


Glu Ile Ser Phe Cys Thr Phe Ser Leu Arg Glu Val Leu Glu Asn Val 
    450                 455                 460                 


Pro Ala Ser Pro Lys Pro Pro Asn Leu Gly Asp Lys Pro Arg Gly Cys 
465                 470                 475                 480 


Cys Trp Pro Ser 
                


<210> 11
<211> 496
<212> PRT
<213> Homo sapiens

<400> 11
Met Met Ser Ser Ala Ala Phe Pro Arg Trp Leu Ser Met Gly Val Pro 
1               5                   10                  15      


Arg Thr Pro Ser Arg Thr Val Leu Phe Glu Arg Glu Arg Thr Gly Leu 
            20                  25                  30          


Thr Tyr Arg Val Pro Ser Leu Leu Pro Val Pro Pro Gly Pro Thr Leu 
        35                  40                  45              


Leu Ala Phe Val Glu Gln Arg Leu Ser Pro Asp Asp Ser His Ala His 
    50                  55                  60                  


Arg Leu Val Leu Arg Arg Gly Thr Leu Ala Gly Gly Ser Val Arg Trp 
65                  70                  75                  80  


Gly Ala Leu His Val Leu Gly Thr Ala Ala Leu Ala Glu His Arg Ser 
                85                  90                  95      


Met Asn Pro Cys Pro Val His Asp Ala Gly Thr Gly Thr Val Phe Leu 
            100                 105                 110         


Phe Phe Ile Ala Val Leu Gly His Thr Pro Glu Ala Val Gln Ile Ala 
        115                 120                 125             


Thr Gly Arg Asn Ala Ala Arg Leu Cys Cys Val Ala Ser Arg Asp Ala 
    130                 135                 140                 


Gly Leu Ser Trp Gly Ser Ala Arg Asp Leu Thr Glu Glu Ala Ile Gly 
145                 150                 155                 160 


Gly Ala Val Gln Asp Trp Ala Thr Phe Ala Val Gly Pro Gly His Gly 
                165                 170                 175     


Val Gln Leu Pro Ser Gly Arg Leu Leu Val Pro Ala Tyr Thr Tyr Arg 
            180                 185                 190         


Val Asp Arg Arg Glu Cys Phe Gly Lys Ile Cys Arg Thr Ser Pro His 
        195                 200                 205             


Ser Phe Ala Phe Tyr Ser Asp Asp His Gly Arg Thr Trp Arg Cys Gly 
    210                 215                 220                 


Gly Leu Val Pro Asn Leu Arg Ser Gly Glu Cys Gln Leu Ala Ala Val 
225                 230                 235                 240 


Asp Gly Gly Gln Ala Gly Ser Phe Leu Tyr Cys Asn Ala Arg Ser Pro 
                245                 250                 255     


Leu Gly Ser Arg Val Gln Ala Leu Ser Thr Asp Glu Gly Thr Ser Phe 
            260                 265                 270         


Leu Pro Ala Glu Arg Val Ala Ser Leu Pro Glu Thr Ala Trp Gly Cys 
        275                 280                 285             


Gln Gly Ser Ile Val Gly Phe Pro Ala Pro Ala Pro Asn Arg Pro Arg 
    290                 295                 300                 


Asp Asp Ser Trp Ser Val Gly Pro Gly Ser Pro Leu Gln Pro Pro Leu 
305                 310                 315                 320 


Leu Gly Pro Gly Val His Glu Pro Pro Glu Glu Ala Ala Val Asp Pro 
                325                 330                 335     


Arg Gly Gly Gln Val Pro Gly Gly Pro Phe Ser Arg Leu Gln Pro Arg 
            340                 345                 350         


Gly Asp Gly Pro Arg Gln Pro Gly Pro Arg Pro Gly Val Ser Gly Asp 
        355                 360                 365             


Val Gly Ser Trp Thr Leu Ala Leu Pro Met Pro Phe Ala Ala Pro Pro 
    370                 375                 380                 


Gln Ser Pro Thr Trp Leu Leu Tyr Ser His Pro Val Gly Arg Arg Ala 
385                 390                 395                 400 


Arg Leu His Met Gly Ile Arg Leu Ser Gln Ser Pro Leu Asp Pro Arg 
                405                 410                 415     


Ser Trp Thr Glu Pro Trp Val Ile Tyr Glu Gly Pro Ser Gly Tyr Ser 
            420                 425                 430         


Asp Leu Ala Ser Ile Gly Pro Ala Pro Glu Gly Gly Leu Val Phe Ala 
        435                 440                 445             


Cys Leu Tyr Glu Ser Gly Ala Arg Thr Ser Tyr Asp Glu Ile Ser Phe 
    450                 455                 460                 


Cys Thr Phe Ser Leu Arg Glu Val Leu Glu Asn Val Pro Ala Ser Pro 
465                 470                 475                 480 


Lys Pro Pro Asn Leu Gly Asp Lys Pro Arg Gly Cys Cys Trp Pro Ser 
                485                 490                 495     


<210> 12
<211> 5
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Ser Leu Pro 
1               5   


<210> 13
<211> 4
<212> PRT
<213> Homo sapiens

<400> 13
Ala Ser Leu Pro 
1               


<210> 14
<211> 8
<212> PRT
<213> Salmonella typhimurium

<400> 14
Thr Val Glu Lys Ser Val Val Phe 
1               5               


<210> 15
<211> 12
<212> PRT
<213> Homo sapiens

<400> 15
Gly Asp Tyr Asp Ala Pro Thr His Gln Val Gln Trp 
1               5                   10          


<210> 16
<211> 8
<212> PRT
<213> Homo sapiens

<400> 16
Ser Met Asp Gln Gly Ser Thr Trp 
1               5               


<210> 17
<211> 8
<212> PRT
<213> Salmonella typhimurium

<400> 17
Ser Thr Asp Gly Gly Lys Thr Trp 
1               5               


<210> 18
<211> 8
<212> PRT
<213> Homo sapiens

<400> 18
Pro Arg Pro Pro Ala Pro Glu Ala 
1               5               


<210> 19
<211> 8
<212> PRT
<213> Homo sapiens

<400> 19
Gln Thr Pro Leu Glu Ala Ala Cys 
1               5               


<210> 20
<211> 9
<212> PRT
<213> Homo sapiens

<400> 20
Asn Pro Arg Pro Pro Ala Pro Glu Ala 
1               5                   


<210> 21
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      recombinant mutant human sialidase sequence

<400> 21
Ser Gln Asn Asp Gly Glu Ser 
1               5           


<210> 22
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      recombinant mutant human sialidase sequence

<400> 22
Leu Ser His Ser Leu Ser Thr 
1               5           


<210> 23
<211> 1092
<212> DNA
<213> Homo sapiens

<400> 23
gagaacgact ttggactggt gcagcctctg gtcaccatgg aacagctgct gtgggtttcc       60

ggcagacaga tcggcagcgt ggacaccttc agaatccctc tgatcaccgc cacacctaga      120

ggcaccctgc tggcctttgc cgaggccaga aagatgagca gctctgacga gggcgccaag      180

tttattgccc tgaggcggtc tatggaccag ggctctacat ggtcccctac cgccttcatc      240

gtgaacgatg gcgacgtgcc cgatggcctg aatctgggag ctgtggtgtc cgatgtggaa      300

accggcgtgg tgttcctgtt ctacagcctg tgtgcccaca aggccggttg tcaggtggcc      360

agcacaatgc tcgtgtggtc caaggacgac ggcgtgtcct ggtctacccc tagaaacctg      420

agcctggaca tcggcaccga agtgtttgct ccaggacctg gctctggcat ccagaagcag      480

agagagccca gaaagggcag actgatcgtg tgtggccacg gcacccttga gagagatggc      540

gttttctgcc tgctgagcga cgatcatggc gcctcttgga gatacggcag cggagtgtct      600

ggaatccctt acggccagcc taagcaagag aacgatttca accccgacga gtgccagcct      660

tacgagctgc ctgatggcag cgtcgtgatc aacgcccgga accagaacaa ctaccactgc      720

cactgccgga tcgtgctgag aagctacgac gcctgcgata ccctgcggcc tagagatgtg      780

accttcgatc ctgagctggt ggaccctgtt gttgccgctg gtgccgtcgt gacatctagc      840

ggcatcgtgt tcttcagcaa ccctgctcac cccgagttca gagtgaatct gaccctgcgg      900

tggtccttca gcaatggcac aagctggcgg aaagaaaccg tgcagctttg gcctggacct      960

agcggctact cttctctggc tacactggaa ggcagcatgg acggcgaaga acaggcccct     1020

cagctgtacg tgctgtacga gaagggcaga aaccactaca ccgagagcat cagcgtggcc     1080

aagatcagcg tt                                                         1092


<210> 24
<211> 1140
<212> DNA
<213> Homo sapiens

<400> 24
atggccagcc tgcctgtgct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cgggccagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gcccctacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgccc agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgtcaagt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccat ccagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agagccagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccacag ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agctgtgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140


<210> 25
<211> 1284
<212> DNA
<213> Homo sapiens

<400> 25
atggaggaag tgaccacctg tagcttcaac agccctctgt tccggcaaga ggacgaccgg       60

ggcatcacct acagaatccc tgctctgctg tacatccctc ctacacacac ctttctggcc      120

ttcgccgaga agcggagcac cagacgagat gaagatgccc tgcacctggt gctgagaaga      180

ggcctgagaa tcggacagct ggtgcagtgg ggacctctga agcctctgat ggaagccaca      240

ctgcccggcc acagaaccat gaatccttgt cctgtgtggg agcagaaaag cggctgcgtg      300

ttcctgttct tcatctgcgt gcggggccac gtgaccgaga gacagcaaat cgtgtccggc      360

agaaacgccg ccagactgtg cttcatctac agccaggatg ccggctgctc ttggagcgaa      420

gttcgggatc tgaccgaaga agtgatcggc agcgagctga agcactgggc cacatttgct      480

gttggccctg gccacggaat ccagctgcaa tctggcagac tggtcatccc cgcctacacc      540

tactatatcc ccagctggtt cttctgcttc caactgcctt gcaagacccg gcctcacagc      600

ctgatgatct acagcgacga tctgggcgtg acatggcacc acggcagact gatcagaccc      660

atggtcaccg tggaatgcga ggtggccgaa gtgacaggca gagctggaca ccctgtgctg      720

tactgctctg ccagaacacc caaccggtgt agagccgagg ctctgtctac agatcacggc      780

gagggctttc agagactggc cctctctaga cagctgtgcg aacctcctca tggctgtcag      840

ggcagcgtgg tgtccttcag acctctggaa atccctcacc ggtgccagga cagcagctct      900

aaggatgccc ctaccatcca gcagtctagc cctggcagca gcctgagact ggaagaggaa      960

gccggaacac ctagcgagag ctggctgctg tactctcacc ccaccagcag aaagcagaga     1020

gtggacctgg gcatctacct gaatcagacc cctctggaag ccgcctgttg gagcagacct     1080

tggattctgc actgtggccc ttgcggctac tctgatctgg ccgctctgga agaagagggc     1140

ctgttcggct gcctgtttga gtgcggcaca aagcaagagt gcgagcagat cgccttccgg     1200

ctgttcaccc acagagagat cctgagccat ctgcagggcg actgcacaag cccaggcaga     1260

aatcccagcc agttcaagag caac                                            1284


<210> 26
<211> 1452
<212> DNA
<213> Homo sapiens

<400> 26
atgggcgtgc ccagaacacc cagcagaacc gtgctgttcg agagagagag gaccggcctg       60

acctacagag tgccttctct gctgcctgtg cctcctggac ctacactgct ggccttcgtg      120

gaacagagac tgagccccga tgattctcac gcccacagac tggtgctgag aagaggaaca      180

ctggctggcg gctctgttag atggggagca ctgcatgtgc tgggcacagc tgctcttgcc      240

gagcacagat ccatgaatcc ctgtcctgtg cacgacgccg gaaccggcac agtgtttctg      300

ttctttatcg ccgtgctggg ccacacacct gaggccgttc aaattgccac cggcagaaat      360

gccgccagac tgtgttgtgt ggcctccaga gatgccggcc tgtcttgggg atctgccaga      420

gatctgaccg aggaagccat tggcggagcc gttcaggatt gggccacatt tgctgttgga      480

cctggacacg gcgtgcagct gccaagtggt agactgctgg tgcctgccta cacatacaga      540

gtggatcgga gagagtgctt cggaaagatc tgccggacaa gccctcacag cttcgccttc      600

tactccgacg atcacggccg gacttggaga tgtggtggcc tggtgcctaa tctgagaagc      660

ggcgaatgtc aactggccgc cgttgatggt ggacaggctg gcagcttcct gtactgcaac      720

gccagatctc ctctgggctc tagagtgcag gccctgtcta ccgatgaggg caccagtttt      780

ctgcccgccg aaagagttgc ctctctgcct gaaacagcct ggggctgtca gggctctatc      840

gtgggatttc ctgctcctgc tccaaacaga ccccgggacg attcttggag tgtcggccct      900

ggatctccac tgcagcctcc attgcttgga ccaggcgttc acgagccacc tgaagaggct      960

gccgttgatc ctagaggcgg acaagttcct ggcggccctt ttagcagact gcagccaaga     1020

ggcgacggcc ctagacaacc tggaccaaga cctggcgtca gcggagatgt tggctcttgg     1080

acactggccc tgcctatgcc ttttgccgct cctcctcagt ctcctacctg gctgctgtac     1140

tctcaccctg ttggcagacg ggccagactg cacatgggca tcagactgtc tcagagccct     1200

ctggacccca gaagctggac agagccttgg gtcatctatg agggccctag cggctacagc     1260

gatctggcct ctattggccc agctcctgaa ggcggactgg tgttcgcttg tctgtatgag     1320

agcggcgcca gaaccagcta cgacgagatc agcttctgca ccttcagcct gcgcgaggtg     1380

ctggaaaatg tgcccgcctc tcctaagcct cctaacctgg gcgataagcc tagaggctgt     1440

tgctggccat ct                                                         1452


<210> 27
<211> 47
<212> PRT
<213> Homo sapiens

<400> 27
Met Thr Gly Glu Arg Pro Ser Thr Ala Leu Pro Asp Arg Arg Trp Gly 
1               5                   10                  15      


Pro Arg Ile Leu Gly Phe Trp Gly Gly Cys Arg Val Trp Val Phe Ala 
            20                  25                  30          


Ala Ile Phe Leu Leu Leu Ser Leu Ala Ala Ser Trp Ser Lys Ala 
        35                  40                  45          


<210> 28
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      recombinant mutant human sialidase sequence

<400> 28
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210> 29
<211> 4
<212> PRT
<213> Homo sapiens

<400> 29
Tyr Gly Thr Leu 
1               


<210> 30
<211> 382
<212> PRT
<213> Salmonella typhimurium

<400> 30
Met Thr Val Glu Lys Ser Val Val Phe Lys Ala Glu Gly Glu His Phe 
1               5                   10                  15      


Thr Asp Gln Lys Gly Asn Thr Ile Val Gly Ser Gly Ser Gly Gly Thr 
            20                  25                  30          


Thr Lys Tyr Phe Arg Ile Pro Ala Met Cys Thr Thr Ser Lys Gly Thr 
        35                  40                  45              


Ile Val Val Phe Ala Asp Ala Arg His Asn Thr Ala Ser Asp Gln Ser 
    50                  55                  60                  


Phe Ile Asp Thr Ala Ala Ala Arg Ser Thr Asp Gly Gly Lys Thr Trp 
65                  70                  75                  80  


Asn Lys Lys Ile Ala Ile Tyr Asn Asp Arg Val Asn Ser Lys Leu Ser 
                85                  90                  95      


Arg Val Met Asp Pro Thr Cys Ile Val Ala Asn Ile Gln Gly Arg Glu 
            100                 105                 110         


Thr Ile Leu Val Met Val Gly Lys Trp Asn Asn Asn Asp Lys Thr Trp 
        115                 120                 125             


Gly Ala Tyr Arg Asp Lys Ala Pro Asp Thr Asp Trp Asp Leu Val Leu 
    130                 135                 140                 


Tyr Lys Ser Thr Asp Asp Gly Val Thr Phe Ser Lys Val Glu Thr Asn 
145                 150                 155                 160 


Ile His Asp Ile Val Thr Lys Asn Gly Thr Ile Ser Ala Met Leu Gly 
                165                 170                 175     


Gly Val Gly Ser Gly Leu Gln Leu Asn Asp Gly Lys Leu Val Phe Pro 
            180                 185                 190         


Val Gln Met Val Arg Thr Lys Asn Ile Thr Thr Val Leu Asn Thr Ser 
        195                 200                 205             


Phe Ile Tyr Ser Thr Asp Gly Ile Thr Trp Ser Leu Pro Ser Gly Tyr 
    210                 215                 220                 


Cys Glu Gly Phe Gly Ser Glu Asn Asn Ile Ile Glu Phe Asn Ala Ser 
225                 230                 235                 240 


Leu Val Asn Asn Ile Arg Asn Ser Gly Leu Arg Arg Ser Phe Glu Thr 
                245                 250                 255     


Lys Asp Phe Gly Lys Thr Trp Thr Glu Phe Pro Pro Met Asp Lys Lys 
            260                 265                 270         


Val Asp Asn Arg Asn His Gly Val Gln Gly Ser Thr Ile Thr Ile Pro 
        275                 280                 285             


Ser Gly Asn Lys Leu Val Ala Ala His Ser Ser Ala Gln Asn Lys Asn 
    290                 295                 300                 


Asn Asp Tyr Thr Arg Ser Asp Ile Ser Leu Tyr Ala His Asn Leu Tyr 
305                 310                 315                 320 


Ser Gly Glu Val Lys Leu Ile Asp Asp Phe Tyr Pro Lys Val Gly Asn 
                325                 330                 335     


Ala Ser Gly Ala Gly Tyr Ser Cys Leu Ser Tyr Arg Lys Asn Val Asp 
            340                 345                 350         


Lys Glu Thr Leu Tyr Val Val Tyr Glu Ala Asn Gly Ser Ile Glu Phe 
        355                 360                 365             


Gln Asp Leu Ser Arg His Leu Pro Val Ile Lys Ser Tyr Asn 
    370                 375                 380         


<210> 31
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 32
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 33
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 34
<211> 1383
<212> DNA
<213> Homo sapiens

<400> 34
atgagacctg cggacctgcc cccgcgcccc atggaagaat ccccggcgtc cagctctgcc       60

ccgacagaga cggaggagcc ggggtccagt gcagaggtca tggaagaagt gacaacatgc      120

tccttcaaca gccctctgtt ccggcaggaa gatgacagag ggattaccta ccggatccca      180

gccctgctct acataccccc cacccacacc ttcctggcct ttgcagagaa gcgttctacg      240

aggagagatg aggatgctct ccacctggtg ctgaggcgag ggttgaggat tgggcagttg      300

gtacagtggg ggcccctgaa gccactgatg gaagccacac taccggggca tcggaccatg      360

aacccctgtc ctgtatggga gcagaagagt ggttgtgtgt tcctgttctt catctgtgtg      420

cggggccatg tcacagagcg tcaacagatt gtgtcaggca ggaatgctgc ccgcctttgc      480

ttcatctaca gtcaggatgc tggatgttca tggagtgagg tgagggactt gactgaggag      540

gtcattggct cagagctgaa gcactgggcc acatttgctg tgggcccagg tcatggcatc      600

cagctgcagt cagggagact ggtcatccct gcgtatacct actacatccc ttcctggttc      660

ttttgcttcc agctaccatg taaaaccagg cctcattctc tgatgatcta cagtgatgac      720

ctaggggtca catggcacca tggtagactc attaggccca tggttacagt agaatgtgaa      780

gtggcagagg tgactgggag ggctggccac cctgtgctat attgcagtgc ccggacacca      840

aacaggtgcc gggcagaggc gctcagcact gaccatggtg aaggctttca gagactggcc      900

ctgagtcgac agctctgtga gcccccacat ggttgccaag ggagtgtggt aagtttccgg      960

cccctggaga tcccacatag gtgccaggac tctagcagca aagatgcacc caccattcag     1020

cagagctctc caggcagttc actgaggctg gaggaggaag ctggaacacc gtcagaatca     1080

tggctcttgt actcacaccc aaccagtagg aaacagaggg ttgacctagg tatctatctc     1140

aaccagaccc ccttggaggc tgcctgctgg tcccgcccct ggatcttgca ctgtgggccc     1200

tgtggctact ctgatctggc tgctctggag gaggagggct tgtttgggtg tttgtttgaa     1260

tgtgggacca agcaagagtg tgagcagatt gccttccgcc tgtttacaca ccgggagatc     1320

ctgagtcacc tgcaggggga ctgcaccagc cctggtagga acccaagcca attcaaaagc     1380

aat                                                                   1383


<210> 35
<211> 1488
<212> DNA
<213> Homo sapiens

<400> 35
atgatgagct ctgcagcctt cccaaggtgg ctgagcatgg gggtccctcg taccccttca       60

cggacagtgc tcttcgagcg ggagaggacg ggcctgacct accgcgtgcc ctcgctgctc      120

cccgtgcccc ccgggcccac cctgctggcc tttgtggagc agcggctcag ccctgacgac      180

tcccacgccc accgcctggt gctgaggagg ggcacgctgg ccgggggctc cgtgcggtgg      240

ggtgccctgc acgtgctggg gacagcagcc ctggcggagc accggtccat gaacccctgc      300

cctgtgcacg atgctggcac gggcaccgtc ttcctcttct tcatcgcggt gctgggccac      360

acgcctgagg ccgtgcagat cgccacggga aggaacgccg cgcgcctctg ctgtgtggcc      420

agccgtgacg ccggcctctc gtggggcagc gcccgggacc tcaccgagga ggccatcggt      480

ggtgccgtgc aggactgggc cacattcgct gtgggtcccg gccacggtgt gcagctgccc      540

tcaggccgcc tgctggtacc cgcctacacc taccgcgtgg accgccgaga gtgttttggc      600

aagatctgcc ggaccagccc tcactccttc gccttctaca gcgatgacca cggccgcacc      660

tggcgctgtg gaggcctcgt gcccaacctg cgctcaggcg agtgccagct ggcagcggtg      720

gacggtgggc aggccggcag cttcctctac tgcaatgccc ggagcccact gggcagccgt      780

gtgcaggcgc tcagcactga cgagggcacc tccttcctgc ccgcagagcg cgtggcttcc      840

ctgcccgaga ctgcctgggg ctgccagggc agcatcgtgg gcttcccagc ccccgccccc      900

aacaggccac gggatgacag ttggtcagtg ggccccggga gtcccctcca gcctccactc      960

ctcggtcctg gagtccacga acccccagag gaggctgctg tagacccccg tggaggccag     1020

gtgcctggtg ggcccttcag ccgtctgcag cctcgggggg atggccccag gcagcctggc     1080

cccaggcctg gggtcagtgg ggatgtgggg tcctggaccc tggcactccc catgcccttt     1140

gctgccccgc cccagagccc cacgtggctg ctgtactccc acccagtggg gcgcagggct     1200

cggctacaca tgggtatccg cctgagccag tccccgctgg acccgcgcag ctggacagag     1260

ccctgggtga tctacgaggg ccccagcggc tactccgacc tggcgtccat cgggccggcc     1320

cctgaggggg gcctggtttt tgcctgcctg tacgagagcg gggccaggac ctcctatgat     1380

gagatttcct tttgtacatt ctccctgcgt gaggtcctgg agaacgtgcc cgccagcccc     1440

aaaccgccca accttgggga caagcctcgg gggtgctgct ggccctcc                  1488


<210> 36
<211> 781
<212> PRT
<213> Vibrio cholera

<400> 36
Met Arg Phe Lys Asn Val Lys Lys Thr Ala Leu Met Leu Ala Met Phe 
1               5                   10                  15      


Gly Met Ala Thr Ser Ser Asn Ala Ala Leu Phe Asp Tyr Asn Ala Thr 
            20                  25                  30          


Gly Asp Thr Glu Phe Asp Ser Pro Ala Lys Gln Gly Trp Met Gln Asp 
        35                  40                  45              


Asn Thr Asn Asn Gly Ser Gly Val Leu Thr Asn Ala Asp Gly Met Pro 
    50                  55                  60                  


Ala Trp Leu Val Gln Gly Ile Gly Gly Arg Ala Gln Trp Thr Tyr Ser 
65                  70                  75                  80  


Leu Ser Thr Asn Gln His Ala Gln Ala Ser Ser Phe Gly Trp Arg Met 
                85                  90                  95      


Thr Thr Glu Met Lys Val Leu Ser Gly Gly Met Ile Thr Asn Tyr Tyr 
            100                 105                 110         


Ala Asn Gly Thr Gln Arg Val Leu Pro Ile Ile Ser Leu Asp Ser Ser 
        115                 120                 125             


Gly Asn Leu Val Val Glu Phe Glu Gly Gln Thr Gly Arg Thr Val Leu 
    130                 135                 140                 


Ala Thr Gly Thr Ala Ala Thr Glu Tyr His Lys Phe Glu Leu Val Phe 
145                 150                 155                 160 


Leu Pro Gly Ser Asn Pro Ser Ala Ser Phe Tyr Phe Asp Gly Lys Leu 
                165                 170                 175     


Ile Arg Asp Asn Ile Gln Pro Thr Ala Ser Lys Gln Asn Met Ile Val 
            180                 185                 190         


Trp Gly Asn Gly Ser Ser Asn Thr Asp Gly Val Ala Ala Tyr Arg Asp 
        195                 200                 205             


Ile Lys Phe Glu Ile Gln Gly Asp Val Ile Phe Arg Gly Pro Asp Arg 
    210                 215                 220                 


Ile Pro Ser Ile Val Ala Ser Ser Val Thr Pro Gly Val Val Thr Ala 
225                 230                 235                 240 


Phe Ala Glu Lys Arg Val Gly Gly Gly Asp Pro Gly Ala Leu Ser Asn 
                245                 250                 255     


Thr Asn Asp Ile Ile Thr Arg Thr Ser Arg Asp Gly Gly Ile Thr Trp 
            260                 265                 270         


Asp Thr Glu Leu Asn Leu Thr Glu Gln Ile Asn Val Ser Asp Glu Phe 
        275                 280                 285             


Asp Phe Ser Asp Pro Arg Pro Ile Tyr Asp Pro Ser Ser Asn Thr Val 
    290                 295                 300                 


Leu Val Ser Tyr Ala Arg Trp Pro Thr Asp Ala Ala Gln Asn Gly Asp 
305                 310                 315                 320 


Arg Ile Lys Pro Trp Met Pro Asn Gly Ile Phe Tyr Ser Val Tyr Asp 
                325                 330                 335     


Val Ala Ser Gly Asn Trp Gln Ala Pro Ile Asp Val Thr Asp Gln Val 
            340                 345                 350         


Lys Glu Arg Ser Phe Gln Ile Ala Gly Trp Gly Gly Ser Glu Leu Tyr 
        355                 360                 365             


Arg Arg Asn Thr Ser Leu Asn Ser Gln Gln Asp Trp Gln Ser Asn Ala 
    370                 375                 380                 


Lys Ile Arg Ile Val Asp Gly Ala Ala Asn Gln Ile Gln Val Ala Asp 
385                 390                 395                 400 


Gly Ser Arg Lys Tyr Val Val Thr Leu Ser Ile Asp Glu Ser Gly Gly 
                405                 410                 415     


Leu Val Ala Asn Leu Asn Gly Val Ser Ala Pro Ile Ile Leu Gln Ser 
            420                 425                 430         


Glu His Ala Lys Val His Ser Phe His Asp Tyr Glu Leu Gln Tyr Ser 
        435                 440                 445             


Ala Leu Asn His Thr Thr Thr Leu Phe Val Asp Gly Gln Gln Ile Thr 
    450                 455                 460                 


Thr Trp Ala Gly Glu Val Ser Gln Glu Asn Asn Ile Gln Phe Gly Asn 
465                 470                 475                 480 


Ala Asp Ala Gln Ile Asp Gly Arg Leu His Val Gln Lys Ile Val Leu 
                485                 490                 495     


Thr Gln Gln Gly His Asn Leu Val Glu Phe Asp Ala Phe Tyr Leu Ala 
            500                 505                 510         


Gln Gln Thr Pro Glu Val Glu Lys Asp Leu Glu Lys Leu Gly Trp Thr 
        515                 520                 525             


Lys Ile Lys Thr Gly Asn Thr Met Ser Leu Tyr Gly Asn Ala Ser Val 
    530                 535                 540                 


Asn Pro Gly Pro Gly His Gly Ile Thr Leu Thr Arg Gln Gln Asn Ile 
545                 550                 555                 560 


Ser Gly Ser Gln Asn Gly Arg Leu Ile Tyr Pro Ala Ile Val Leu Asp 
                565                 570                 575     


Arg Phe Phe Leu Asn Val Met Ser Ile Tyr Ser Asp Asp Gly Gly Ser 
            580                 585                 590         


Asn Trp Gln Thr Gly Ser Thr Leu Pro Ile Pro Phe Arg Trp Lys Ser 
        595                 600                 605             


Ser Ser Ile Leu Glu Thr Leu Glu Pro Ser Glu Ala Asp Met Val Glu 
    610                 615                 620                 


Leu Gln Asn Gly Asp Leu Leu Leu Thr Ala Arg Leu Asp Phe Asn Gln 
625                 630                 635                 640 


Ile Val Asn Gly Val Asn Tyr Ser Pro Arg Gln Gln Phe Leu Ser Lys 
                645                 650                 655     


Asp Gly Gly Ile Thr Trp Ser Leu Leu Glu Ala Asn Asn Ala Asn Val 
            660                 665                 670         


Phe Ser Asn Ile Ser Thr Gly Thr Val Asp Ala Ser Ile Thr Arg Phe 
        675                 680                 685             


Glu Gln Ser Asp Gly Ser His Phe Leu Leu Phe Thr Asn Pro Gln Gly 
    690                 695                 700                 


Asn Pro Ala Gly Thr Asn Gly Arg Gln Asn Leu Gly Leu Trp Phe Ser 
705                 710                 715                 720 


Phe Asp Glu Gly Val Thr Trp Lys Gly Pro Ile Gln Leu Val Asn Gly 
                725                 730                 735     


Ala Ser Ala Tyr Ser Asp Ile Tyr Gln Leu Asp Ser Glu Asn Ala Ile 
            740                 745                 750         


Val Ile Val Glu Thr Asp Asn Ser Asn Met Arg Ile Leu Arg Met Pro 
        755                 760                 765             


Ile Thr Leu Leu Lys Gln Lys Leu Thr Leu Ser Gln Asn 
    770                 775                 780     


<210> 37
<211> 2424
<212> DNA
<213> Vibrio cholera

<400> 37
ttgtcaatca agatgacttc acaacgaaga agagcatcga ttcacaagga aacagattct       60

aatataaagg gagtagatat gcgtttcaaa aacgtaaaga aaaccgcttt aatgcttgca      120

atgttcggta tggcgacaag ctcaaacgcc gcactttttg actataacgc aacgggtgac      180

actgagtttg acagtccagc caaacaggga tggatgcaag acaacacgaa taatggcagc      240

ggcgttttaa ccaatgcaga tggaatgccc gcttggttgg tgcaaggtat tggagggaga      300

gctcaatgga catattctct ctctactaat caacatgccc aagcatcaag tttcggttgg      360

cgaatgacga cagaaatgaa agtgctcagt ggtggaatga tcacaaacta ctacgccaac      420

ggcactcagc gtgtcttacc catcatttca ttagatagca gtggtaactt agttgttgag      480

tttgaagggc aaactggacg caccgttttg gcaaccggca cagcagcaac ggaatatcat      540

aaatttgaat tggtattcct tcctggaagt aacccatccg ctagctttta cttcgatggc      600

aaactcattc gtgacaacat ccagccgact gcatcaaaac aaaatatgat cgtatggggg      660

aatggctcat caaatacgga tggtgtcgcc gcttatcgtg atattaagtt tgaaattcaa      720

ggcgacgtca tcttcagagg cccagaccgt ataccgtcca ttgtagcaag tagcgtaaca      780

ccaggggtgg taaccgcatt tgcagagaaa cgtgtggggg gaggagatcc cggtgctctg      840

agtaatacca atgacataat cactcgtacc tcacgagatg gcggtataac ttgggatacc      900

gagctcaacc tcactgagca aatcaatgtc agtgatgagt ttgatttctc cgatcctcgg      960

cctatctatg atccttcctc caatacggtt cttgtctctt atgctcgatg gccgaccgat     1020

gccgctcaaa acggagatcg aataaaacca tggatgccaa acggtatttt ttacagcgtc     1080

tatgatgttg catcagggaa ctggcaagcg cctatcgatg ttaccgatca ggtgaaagaa     1140

cgcagtttcc aaatcgctgg ttggggtggt tcagagctgt atcgccgaaa taccagccta     1200

aatagccagc aagactggca atcaaacgct aagatccgaa ttgttgatgg tgcagcgaac     1260

cagatacaag ttgccgatgg tagccgaaaa tatgttgtca cactgagtat tgatgaatca     1320

ggtggtctag tcgctaatct aaacggtgtt agtgctccga ttatcctgca atctgaacac     1380

gcaaaggtac actctttcca tgactacgaa cttcaatatt cggcgttaaa ccacaccaca     1440

acgttattcg tggatggtca gcaaatcaca acttgggctg gcgaagtatc gcaggagaac     1500

aacattcagt ttggtaatgc ggatgcccaa attgacggca gactgcatgt gcaaaaaatt     1560

gttctcacac agcaaggcca taacctcgtg gagtttgatg ctttctattt agcacagcaa     1620

acccctgaag tagagaaaga ccttgaaaag cttggttgga caaaaattaa aacgggcaac     1680

accatgagtt tgtatggaaa tgccagtgtc aacccaggac cgggtcatgg catcaccctt     1740

actcgacaac aaaatatcag tggcagccaa aacggccgct tgatctaccc agcgattgtg     1800

cttgatcgtt tcttcttgaa cgtcatgtct atttacagtg atgatggcgg ttcaaactgg     1860

caaaccggtt caacactccc tatccccttt cgctggaaga gttcgagtat cctagaaact     1920

ctcgaaccta gtgaagctga tatggttgaa ctccaaaacg gtgatctact ccttactgca     1980

cgccttgatt ttaaccaaat cgttaatggt gtgaactata gcccacgcca gcaatttttg     2040

agtaaagatg gtggaatcac gtggagccta cttgaggcta acaacgctaa cgtctttagc     2100

aatatcagta ctggtaccgt tgatgcttct attactcggt tcgagcaaag tgacggtagc     2160

catttcttac tctttactaa cccacaagga aaccctgcgg ggacaaatgg caggcaaaat     2220

ctaggcttat ggtttagctt cgatgaaggg gtgacatgga aaggaccaat tcaacttgtt     2280

aatggtgcat cggcatattc tgatatttat caattggatt cggaaaatgc gattgtcatt     2340

gttgaaacgg ataattcaaa tatgcgaatt cttcgtatgc ctatcacatt gctaaaacag     2400

aagctgacct tatcgcaaaa ctaa                                            2424


<210> 38
<211> 409
<212> PRT
<213> Mus musculus

<400> 38
Met Val Gly Ala Asp Pro Thr Arg Pro Arg Gly Pro Leu Ser Tyr Trp 
1               5                   10                  15      


Ala Gly Arg Arg Gly Gln Gly Leu Ala Ala Ile Phe Leu Leu Leu Val 
            20                  25                  30          


Ser Ala Ala Glu Ser Glu Ala Arg Ala Glu Asp Asp Phe Ser Leu Val 
        35                  40                  45              


Gln Pro Leu Val Thr Met Glu Gln Leu Leu Trp Val Ser Gly Lys Gln 
    50                  55                  60                  


Ile Gly Ser Val Asp Thr Phe Arg Ile Pro Leu Ile Thr Ala Thr Pro 
65                  70                  75                  80  


Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala Arg Lys Lys Ser Ala Ser 
                85                  90                  95      


Asp Glu Gly Ala Lys Phe Ile Ala Met Arg Arg Ser Thr Asp Gln Gly 
            100                 105                 110         


Ser Thr Trp Ser Ser Thr Ala Phe Ile Val Asp Asp Gly Glu Ala Ser 
        115                 120                 125             


Asp Gly Leu Asn Leu Gly Ala Val Val Asn Asp Val Asp Thr Gly Ile 
    130                 135                 140                 


Val Phe Leu Ile Tyr Thr Leu Cys Ala His Lys Val Asn Cys Gln Val 
145                 150                 155                 160 


Ala Ser Thr Met Leu Val Trp Ser Lys Asp Asp Gly Ile Ser Trp Ser 
                165                 170                 175     


Pro Pro Arg Asn Leu Ser Val Asp Ile Gly Thr Glu Met Phe Ala Pro 
            180                 185                 190         


Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg Glu Pro Gly Lys Gly Arg 
        195                 200                 205             


Leu Ile Val Cys Gly His Gly Thr Leu Glu Arg Asp Gly Val Phe Cys 
    210                 215                 220                 


Leu Leu Ser Asp Asp His Gly Ala Ser Trp His Tyr Gly Thr Gly Val 
225                 230                 235                 240 


Ser Gly Ile Pro Phe Gly Gln Pro Lys His Asp His Asp Phe Asn Pro 
                245                 250                 255     


Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp Gly Ser Val Ile Ile Asn 
            260                 265                 270         


Ala Arg Asn Gln Asn Asn Tyr His Cys Arg Cys Arg Ile Val Leu Arg 
        275                 280                 285             


Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro Arg Asp Val Thr Phe Asp 
    290                 295                 300                 


Pro Glu Leu Val Asp Pro Val Val Ala Ala Gly Ala Leu Ala Thr Ser 
305                 310                 315                 320 


Ser Gly Ile Val Phe Phe Ser Asn Pro Ala His Pro Glu Phe Arg Val 
                325                 330                 335     


Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn Gly Thr Ser Trp Leu Lys 
            340                 345                 350         


Glu Arg Val Gln Val Trp Pro Gly Pro Ser Gly Tyr Ser Ser Leu Thr 
        355                 360                 365             


Ala Leu Glu Asn Ser Thr Asp Gly Lys Lys Gln Pro Pro Gln Leu Phe 
    370                 375                 380                 


Val Leu Tyr Glu Lys Gly Leu Asn Arg Tyr Thr Glu Ser Ile Ser Met 
385                 390                 395                 400 


Val Lys Ile Ser Val Tyr Gly Thr Leu 
                405                 


<210> 39
<211> 393
<212> PRT
<213> Mus musculus

<400> 39
Met Thr Val Gln Pro Ser Pro Trp Phe Ser Asp Leu Arg Pro Met Ala 
1               5                   10                  15      


Thr Cys Pro Val Leu Gln Lys Glu Thr Leu Phe Arg Thr Gly Val His 
            20                  25                  30          


Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Lys Lys Gln Lys Thr Leu 
        35                  40                  45              


Leu Ala Phe Ala Glu Lys Arg Ala Ser Lys Thr Asp Glu His Ala Glu 
    50                  55                  60                  


Leu Ile Val Leu Arg Arg Gly Ser Tyr Asn Glu Ala Thr Asn Arg Val 
65                  70                  75                  80  


Lys Trp Gln Pro Glu Glu Val Val Thr Gln Ala Gln Leu Glu Gly His 
                85                  90                  95      


Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Lys Gln Thr Lys Thr Leu 
            100                 105                 110         


Phe Leu Phe Phe Ile Ala Val Pro Gly Arg Val Ser Glu His His Gln 
        115                 120                 125             


Leu His Thr Lys Val Asn Val Thr Arg Leu Cys Cys Val Ser Ser Thr 
    130                 135                 140                 


Asp His Gly Arg Thr Trp Ser Pro Ile Gln Asp Leu Thr Glu Thr Thr 
145                 150                 155                 160 


Ile Gly Ser Thr His Gln Glu Trp Ala Thr Phe Ala Val Gly Pro Gly 
                165                 170                 175     


His Cys Leu Gln Leu Arg Asn Pro Ala Gly Ser Leu Leu Val Pro Ala 
            180                 185                 190         


Tyr Ala Tyr Arg Lys Leu His Pro Ala Gln Lys Pro Thr Pro Phe Ala 
        195                 200                 205             


Phe Cys Phe Ile Ser Leu Asp His Gly His Thr Trp Lys Leu Gly Asn 
    210                 215                 220                 


Phe Val Ala Glu Asn Ser Leu Glu Cys Gln Val Ala Glu Val Gly Thr 
225                 230                 235                 240 


Gly Ala Gln Arg Met Val Tyr Leu Asn Ala Arg Ser Phe Leu Gly Ala 
                245                 250                 255     


Arg Val Gln Ala Gln Ser Pro Asn Asp Gly Leu Asp Phe Gln Asp Asn 
            260                 265                 270         


Arg Val Val Ser Lys Leu Val Glu Pro Pro His Gly Cys His Gly Ser 
        275                 280                 285             


Val Val Ala Phe His Asn Pro Ile Ser Lys Pro His Ala Leu Asp Thr 
    290                 295                 300                 


Trp Leu Leu Tyr Thr His Pro Thr Asp Ser Arg Asn Arg Thr Asn Leu 
305                 310                 315                 320 


Gly Val Tyr Leu Asn Gln Met Pro Leu Asp Pro Thr Ala Trp Ser Glu 
                325                 330                 335     


Pro Thr Leu Leu Ala Met Gly Ile Cys Ala Tyr Ser Asp Leu Gln Asn 
            340                 345                 350         


Met Gly Gln Gly Pro Asp Gly Ser Pro Gln Phe Gly Cys Leu Tyr Glu 
        355                 360                 365             


Ser Gly Asn Tyr Glu Glu Ile Ile Phe Leu Ile Phe Thr Leu Lys Gln 
    370                 375                 380                 


Ala Phe Pro Thr Val Phe Asp Ala Gln 
385                 390             


<210> 40
<211> 418
<212> PRT
<213> Mus musculus

<400> 40
Met Glu Glu Val Pro Pro Tyr Ser Leu Ser Ser Thr Leu Phe Gln Gln 
1               5                   10                  15      


Glu Glu Gln Ser Gly Val Thr Tyr Arg Ile Pro Ala Leu Leu Tyr Leu 
            20                  25                  30          


Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Thr Ser Val 
        35                  40                  45              


Arg Asp Glu Asp Ala Ala Cys Leu Val Leu Arg Arg Gly Leu Met Lys 
    50                  55                  60                  


Gly Arg Ser Val Gln Trp Gly Pro Gln Arg Leu Leu Met Glu Ala Thr 
65                  70                  75                  80  


Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Lys Asn 
                85                  90                  95      


Thr Gly Arg Val Tyr Leu Phe Phe Ile Cys Val Arg Gly His Val Thr 
            100                 105                 110         


Glu Arg Cys Gln Ile Val Trp Gly Lys Asn Ala Ala Arg Leu Cys Phe 
        115                 120                 125             


Leu Cys Ser Glu Asp Ala Gly Cys Ser Trp Gly Glu Val Lys Asp Leu 
    130                 135                 140                 


Thr Glu Glu Val Ile Gly Ser Glu Val Lys Arg Trp Ala Thr Phe Ala 
145                 150                 155                 160 


Val Gly Pro Gly His Gly Ile Gln Leu His Ser Gly Arg Leu Ile Ile 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Tyr Val Ser Arg Trp Phe Leu Cys Phe Ala Cys 
            180                 185                 190         


Ser Val Lys Pro His Ser Leu Met Ile Tyr Ser Asp Asp Phe Gly Val 
        195                 200                 205             


Thr Trp His His Gly Lys Phe Ile Glu Pro Gln Val Thr Gly Glu Cys 
    210                 215                 220                 


Gln Val Ala Glu Val Ala Gly Thr Ala Gly Asn Pro Val Leu Tyr Cys 
225                 230                 235                 240 


Ser Ala Arg Thr Pro Ser Arg Phe Arg Ala Glu Ala Phe Ser Thr Asp 
                245                 250                 255     


Ser Gly Gly Cys Phe Gln Lys Pro Thr Leu Asn Pro Gln Leu His Glu 
            260                 265                 270         


Pro Arg Thr Gly Cys Gln Gly Ser Val Val Ser Phe Arg Pro Leu Lys 
        275                 280                 285             


Met Pro Asn Thr Tyr Gln Asp Ser Ile Gly Lys Gly Ala Pro Ala Thr 
    290                 295                 300                 


Gln Lys Cys Pro Leu Leu Asp Ser Pro Leu Glu Val Glu Lys Gly Ala 
305                 310                 315                 320 


Glu Thr Pro Ser Ala Thr Trp Leu Leu Tyr Ser His Pro Thr Ser Lys 
                325                 330                 335     


Arg Lys Arg Ile Asn Leu Gly Ile Tyr Tyr Asn Arg Asn Pro Leu Glu 
            340                 345                 350         


Val Asn Cys Trp Ser Arg Pro Trp Ile Leu Asn Arg Gly Pro Ser Gly 
        355                 360                 365             


Tyr Ser Asp Leu Ala Val Val Glu Glu Gln Asp Leu Val Ala Cys Leu 
    370                 375                 380                 


Phe Glu Cys Gly Glu Lys Asn Glu Tyr Glu Arg Ile Asp Phe Cys Leu 
385                 390                 395                 400 


Phe Ser Asp His Glu Val Leu Ser Cys Glu Asp Cys Thr Ser Pro Ser 
                405                 410                 415     


Ser Asp 
        


<210> 41
<211> 501
<212> PRT
<213> Mus musculus

<400> 41
Met Glu Thr Ala Gly Ala Pro Phe Cys Phe His Val Asp Ser Leu Val 
1               5                   10                  15      


Pro Cys Ser Tyr Trp Lys Val Met Gly Pro Thr Arg Val Pro Arg Arg 
            20                  25                  30          


Thr Val Leu Phe Gln Arg Glu Arg Thr Gly Leu Thr Tyr Arg Val Pro 
        35                  40                  45              


Ala Leu Leu Cys Val Pro Pro Arg Pro Thr Leu Leu Ala Phe Ala Glu 
    50                  55                  60                  


Gln Arg Leu Ser Pro Asp Asp Ser His Ala His Arg Leu Val Leu Arg 
65                  70                  75                  80  


Arg Gly Thr Leu Thr Arg Gly Ser Val Arg Trp Gly Thr Leu Ser Val 
                85                  90                  95      


Leu Glu Thr Ala Val Leu Glu Glu His Arg Ser Met Asn Pro Cys Pro 
            100                 105                 110         


Val Leu Asp Glu His Ser Gly Thr Ile Phe Leu Phe Phe Ile Ala Val 
        115                 120                 125             


Leu Gly His Thr Pro Glu Ala Val Gln Ile Ala Thr Gly Lys Asn Ala 
    130                 135                 140                 


Ala Arg Leu Cys Cys Val Thr Ser Cys Asp Ala Gly Leu Thr Trp Gly 
145                 150                 155                 160 


Ser Val Arg Asp Leu Thr Glu Glu Ala Ile Gly Ala Ala Leu Gln Asp 
                165                 170                 175     


Trp Ala Thr Phe Ala Val Gly Pro Gly His Gly Val Gln Leu Arg Ser 
            180                 185                 190         


Gly Arg Leu Leu Val Pro Ala Tyr Thr Tyr His Val Asp Arg Arg Glu 
        195                 200                 205             


Cys Phe Gly Lys Ile Cys Trp Thr Ser Pro His Ser Leu Ala Phe Tyr 
    210                 215                 220                 


Ser Asp Asp His Gly Ile Ser Trp His Cys Gly Gly Leu Val Pro Asn 
225                 230                 235                 240 


Leu Arg Ser Gly Glu Cys Gln Leu Ala Ala Val Asp Gly Asp Phe Leu 
                245                 250                 255     


Tyr Cys Asn Ala Arg Ser Pro Leu Gly Asn Arg Val Gln Ala Leu Ser 
            260                 265                 270         


Ala Asp Glu Gly Thr Ser Phe Leu Pro Gly Glu Leu Val Pro Thr Leu 
        275                 280                 285             


Ala Glu Thr Ala Arg Gly Cys Gln Gly Ser Ile Val Gly Phe Leu Ala 
    290                 295                 300                 


Pro Pro Ser Ile Glu Pro Gln Asp Asp Arg Trp Thr Gly Ser Pro Arg 
305                 310                 315                 320 


Asn Thr Pro His Ser Pro Cys Phe Asn Leu Arg Val Gln Glu Ser Ser 
                325                 330                 335     


Gly Glu Gly Ala Arg Gly Leu Leu Glu Arg Trp Met Pro Arg Leu Pro 
            340                 345                 350         


Leu Cys Tyr Pro Gln Ser Arg Ser Pro Glu Asn His Gly Leu Glu Pro 
        355                 360                 365             


Gly Ser Asp Gly Asp Lys Thr Ser Trp Thr Pro Glu Cys Pro Met Ser 
    370                 375                 380                 


Ser Asp Ser Met Leu Gln Ser Pro Thr Trp Leu Leu Tyr Ser His Pro 
385                 390                 395                 400 


Ala Gly Arg Arg Ala Arg Leu His Met Gly Ile Tyr Leu Ser Arg Ser 
                405                 410                 415     


Pro Leu Asp Pro His Ser Trp Thr Glu Pro Trp Val Ile Tyr Glu Gly 
            420                 425                 430         


Pro Ser Gly Tyr Ser Asp Leu Ala Phe Leu Gly Pro Met Pro Gly Ala 
        435                 440                 445             


Ser Leu Val Phe Ala Cys Leu Phe Glu Ser Gly Thr Arg Thr Ser Tyr 
    450                 455                 460                 


Glu Asp Ile Ser Phe Cys Leu Phe Ser Leu Ala Asp Val Leu Glu Asn 
465                 470                 475                 480 


Val Pro Thr Gly Leu Glu Met Leu Ser Leu Arg Asp Lys Ala Gln Gly 
                485                 490                 495     


His Cys Trp Pro Ser 
            500     


<210> 42
<211> 3850
<212> DNA
<213> Mus musculus

<400> 42
gggtcacatg ctgatggact aattggagtc gcggcagcgc gggctgcggc ccccaagggg       60

aggggtcgga gtgacgtgcg cgcttttaaa gggccgaggt cagctgacgg cttgccaccg      120

gtgaccagtt cctggacagg gatcgccggg agctatggtg ggggcagacc cgaccagacc      180

ccggggaccg ctgagctatt gggcgggccg tcggggtcag gggctcgcag cgatcttcct      240

gctcctggtg tccgcggcgg aatccgaggc cagggcagag gatgacttca gcctggtgca      300

gccgctggtg accatggagc agctgctgtg ggtgagcggg aagcagatcg gctctgtaga      360

cactttccgc atcccgctca tcacagccac ccctcggggc acgctcctgg ccttcgctga      420

ggccaggaaa aaatctgcat ccgatgaggg ggccaagttc atcgccatga ggaggtccac      480

ggaccagggt agcacgtggt cctctacagc cttcatcgta gacgatgggg aggcctccga      540

tggcctgaac ctgggcgctg tggtgaacga tgtagacaca gggatagtgt tccttatcta      600

taccctctgt gctcacaagg tcaactgcca ggtggcctct accatgttgg tttggagtaa      660

ggacgacggc atttcctgga gcccaccccg gaatctctct gtggatattg gcacagagat      720

gtttgcccct ggacctggct caggcattca gaaacagcgg gagcctggga agggccggct      780

cattgtgtgt ggacacggga cgctggagcg agatggggtc ttctgtctcc tcagtgatga      840

ccacggtgcc tcctggcact acggcactgg agtgagcggc attccctttg gccagcccaa      900

acacgatcac gatttcaacc ccgacgagtg ccagccctac gagcttccag atggctcggt      960

catcatcaac gcccggaacc agaataacta ccattgccgc tgcaggatcg tcctccgcag     1020

ctatgacgcc tgtgacaccc tcaggccccg ggatgtgacc ttcgaccctg agctcgtgga     1080

ccctgtggta gctgcaggag cactagccac cagctccggc attgtcttct tctccaatcc     1140

agcccaccct gagttccgag tgaacctgac cctgcgctgg agtttcagca atggtacatc     1200

ctggcagaag gagagggtcc aggtgtggcc gggacccagc ggctactcgt ccctgacagc     1260

cctggaaaac agcacggatg gaaagaagca gcccccgcag ctgttcgttc tgtacgagaa     1320

aggcctgaac cggtacaccg agagcatctc catggtcaaa atcagcgtct acggcacgct     1380

ctgagccccg tgcccaaagg acaccaagtc ctggtcgctg acttcacagc tctctggacc     1440

atctgcagag ggtgcctgaa acacagctct tcctctgaac tctgaccttt tgcaacttct     1500

catcaacagg gaagtctctt cgttatgact taacacccag cttcctctcg gggcaggaag     1560

tccctccgtc accaagagca cttttttcca gtatgctggg gatggcccct gtccattctc     1620

ttccaggaca acggagctgt gcctttctgg gacaggatgg gggaggggct ccccctggag     1680

agatgaacag atacgaactc agggaactga gaaggcccgg tgtcctaggg tacaaaggca     1740

ggtactagat gtgattgctg aaagtcccca gggcagagtg tcctttcaga gcaaggataa     1800

gcacacctac gtgtgcacct ttgattattt atgaatcgaa atatttgtaa cttaaaattt     1860

ttgatgcaga aaaagcgttt gtggagtctg tggttctgtc tgctcacgcc ttcccaattg     1920

cctcctggag agacaggaag gcagctggaa gaggagccga tgtacttact gggaagcaga     1980

aacccctaga ttccatcctg gctgctgctg tttgcaagtg tcaaagatgg gggggcgtgt     2040

ttatatttta tatttctaag atggggtggc ataggaaata gggaacagat gtgtaaaacc     2100

agatgggaag gacagtctgt gagaaaggag caagcagttg ctgcaggtgt gggagagcaa     2160

agcccttctc cacgtggaaa gagcccagat ggacgctaag catgttgggc acctgtaacc     2220

ccgcactcgc tggactgacg gtgtagctca gtggtggagc tagtacttgg aacgcctaag     2280

actctgggtt cagtccttgg gggggggggt atgtgtttat tgagaggaag gtgtacgtac     2340

tgtaggtcag aggacagctt actggagttg tctctctcct tcacgctgtg agtcctgtgg     2400

aatgacctca ggtgtcagag ttgggggcag gtgcctttgc cagctgagcc atcttgctgt     2460

ctctgcttta atttaaaaaa aaaaaaaaaa aagaatatta aggtctgagg gattcgggct     2520

gcgttcattt caattagagg gtcatatttc ttttgacatt tcttctctaa gaaatgttaa     2580

gatcatttgt tctgtgtgat agaggtatag ctccattgta tgtcagcagt gagggatcct     2640

gtgcatttta tccagagttt gtacggtgtt ctaggggctg ctagtgcagc ccagtgctaa     2700

acacttcagc atgcacaagg cctcaatcag tgcatgcatg tgcacacaca cacagacaca     2760

cacgtacaca ctgacacagg tacacaaata cacactggcc cacatgtaca catcgactca     2820

caggtacaca gacccacttt gacacacata tacacagaca caaacgcact ggcacacaca     2880

tatacacagg cacacatgga tagatggaca cacgtgtaca catacacaca cacacagaaa     2940

tacaaatgtt caggttttct aaaaaaaaaa aaattagaga cgtgttgact tcatttttag     3000

caaaaatcct gtcatgtatc ttaaagtgga ttgaacccac tatgtagccc aggctggcct     3060

ccaaatgggc atccttctgc ctcagtctcc cgagggctag gataacagga gtatgccatc     3120

acacctggct aatagaaatt ttcaaaattg tttgtttgaa ggtgactctt actatattgc     3180

ctaactgatc tccagttcgt gaaatcctcc tgcctcagaa ccaggactgt caatataacc     3240

caccaagaca ggccaacatt cacaattgat tgttagtttg tggtctgaat caaggtctta     3300

tactgtagcc caggctagcc cggaatacac gatatctcca gtgcttcaga tcctcagttc     3360

taactaagca tggccacatc catgtttaac tgcaaatttg atgttaccat ggtttggttt     3420

ggtttggttt ggtttggttt ggtttggttt ggttttttgg ccattttttt tttctcatgc     3480

tgaggccttg tgctctcaag ttggggagac agcatggagg gtagctgcaa ctgtaacccc     3540

agttccaggg gacctgacac cctctggcct ccacaagtat taggcacatc tgtggtgcac     3600

agacatacaa tcaggcaaaa tattcataca cataaaataa aataatttaa aacaaaagca     3660

aaaatcagga cctaagaaaa aaatctattc ctgattcttt tatgttttgt ttgtatttta     3720

tcaagacagg gttgtttctc tgtatagccc tggctgtctt ggaattcact ctgtagacca     3780

ggctggcctc aaactcagaa atcctcctgc ctttgccttc caagtgctgg aattaaaggc     3840

atgcgccacc                                                            3850


<210> 43
<211> 1722
<212> DNA
<213> Mus musculus

<400> 43
gacatgaccc aaacggcccc tggctgcaag gtaatatcgg aagttgacta agaatggacg       60

ccccaccact gactgacccg ccccctgagt ctgagattgg acttgtctct ggatacagtc      120

atactttgag gtactacaag ttagaaactg ttaggttact cagttcagtc catgacagtc      180

caaccttctc catggttttc cgatctcagg cccatggcga cctgccctgt cctgcagaag      240

gagacactgt tccgcacagg cgtccatgct tacagaatcc ctgctctgct ctacctgaag      300

aagcagaaga ccctgctggc ctttgcggaa aagcgagcca gcaagacgga tgagcacgca      360

gagttgattg tcctgagaag aggaagctac aacgaagcca ccaaccgtgt caagtggcag      420

cctgaggaag tggtgaccca agcccagctg gaaggccacc gctccatgaa tccatgtccc      480

ttgtatgaca agcaaacaaa gaccctcttc cttttcttca tcgctgtccc tgggcgtgta      540

tcagaacatc atcagctcca cactaaggtt aatgtcacac ggctgtgctg tgtcagcagc      600

actgaccatg ggaggacctg gagccccatc caggacctca cagagaccac cattggcagc      660

actcatcagg aatgggccac atttgctgtg ggtcctgggc attgtctgca gctgcggaac      720

ccagctggga gcctgctggt acctgcttat gcctaccgga aactgcaccc tgctcagaag      780

cctaccccct ttgccttctg cttcatcagc cttgaccatg ggcacacatg gaaactaggc      840

aactttgtgg ctgaaaactc actggagtgc caggtggctg aggttggcac tggagctcag      900

aggatggtat atctcaatgc taggagcttc ctgggagcca gggtccaggc acaaagtcct      960

aatgatggtc tggatttcca ggacaaccgg gtagtgagta agcttgtaga gcccccccac     1020

gggtgtcatg gaagtgtggt tgccttccac aaccccatct ctaagccaca tgccttagac     1080

acatggcttc tttatacaca ccctacagac tccaggaata gaaccaacct gggtgtgtac     1140

ctaaaccaga tgccactaga tcccacagcc tggtcagagc ccaccctgct ggccatgggc     1200

atctgtgcct actcagactt acagaacatg gggcaaggcc ctgatggctc cccacagttt     1260

gggtgtctgt atgaatcagg taactatgaa gagatcattt tcctcatatt caccctgaag     1320

caagctttcc ccactgtatt tgatgcccag tgatctcagt gcacgtggcc caaagggctt     1380

ccttgtgctt caaaacaccc atctctcttt gcttccagca tcctctggac tcttgagtcc     1440

agctcttggg taacttcctc aggaggatgc agagaatttg gtctcttgac tctctgcagg     1500

ccttattgtt tcagcctctg gttctctttt cagcccagaa atcaaaggag cctggctttc     1560

ctcagcctgt tggcagggca ggtggggaca gtatatatag aggctgccat tctgcatgtc     1620

ggttgtcact atgctagttt aacctgcctg tttccccatg cctagtgttt gaatgagtat     1680

taataaaata tccaacccag cccatttctt cctggaaaaa aa                        1722


<210> 44
<211> 3340
<212> DNA
<213> Mus musculus

<400> 44
actgcgcggt gaaggggcgt ggcctggccg gggaggttga cacccagacg ctgctctcag       60

tcctctggcg cctgctcccc agcgcattcc ttctgctcct gggatatttg tctcattact      120

gccagttctt gcgcagcggt cactgggttc gtttcagcgt ctgtggtttc tgtcgctgtt      180

atccagtctc catcgcccca gctcagcttc aggccttctt ccgagactcc acgggagagc      240

ccagagagcc tccggagccg aagccatgga ggaagtccca ccctactccc tcagcagcac      300

cctgttccag caggaagaac agagtggggt gacctaccgg atcccagccc tgctgtacct      360

tcctcccacc cacaccttcc tggcctttgc agagaagcgg acctcagtca gagatgagga      420

tgctgcctgc ctggtgctca gacgagggct gatgaagggg cgctctgtac agtggggccc      480

ccaacggcta ctgatggagg ccacattacc tgggcatcgc accatgaacc cctgccctgt      540

gtgggagaaa aatactggcc gtgtgtacct gtttttcatc tgtgtgcggg gccatgttac      600

tgagaggtgc cagattgtgt ggggcaaaaa tgccgcccgt ctctgcttcc tttgcagtga      660

agatgccggc tgctcttggg gtgaagtgaa agacttgacc gaggaggtca ttggctcaga      720

ggtgaagcgc tgggccacat ttgctgtggg cccaggtcat ggcatccagc tacactcggg      780

aaggctgatc atccccgcct atgcctacta tgtctcacgt tggtttctct gctttgcgtg      840

ttcagtcaag ccccattccc tgatgatcta cagtgatgac tttggagtca catggcacca      900

tggcaagttc attgagcccc aggtgacagg ggagtgccaa gtggccgaag tggctgggac      960

ggctggtaac cctgtgctca ctgcagtgcc cgaacaccaa gccgatttcg agcagaggct     1020

tttagtactg atagtggtgg ctgctttcag aagccaaccc tgaacccaca actccatgag     1080

cctcgaaccg gctgccaagg tagtgtagtg agcttccggc ctttgaagat gccaaatacc     1140

tatcaagact caattggcaa aggtgctccc gctactcaga agtgccctct gctggacagt     1200

cctctggagg tggagaaagg agctgaaaca ccatcagcaa catggctctt gtactcacat     1260

ccaactagca agaggaagag gattaaccta ggcatctact acaaccggaa ccccttggag     1320

gtgaactgct ggtcccgccc gtggatcttg aaccgtgggc ccagtggcta ctctgatctg     1380

gctgttgtgg aagaacagga cttggtggcg tgtttgtttg agtgtgggga gaagaatgag     1440

tatgagcgga ttgacttctg tctgttttca gaccatgagg tcctgagctg tgaagactgt     1500

accagcccta gtagcgacta aagccaaatc aagacggatg agtgaggccc agcttcccac     1560

agaaaggaat ggcagctaca gccagggtaa cagaggtctc tgatgtctag agaaaactct     1620

aaaaactaat aatctgctcc ttgaattttt tcacttttcc cttcaatgag catggtgaaa     1680

attgtgccat atcttacata acgaggctct tgaactggga gtttgaatct cttctcttcc     1740

cattaaaagg agaggccatg tgctcgcttc gcgttcgaca aagcctggat tctgatcttg     1800

agtggaagcc acaggcttgt cttttccaat ggttcactgc tcacctgagt attaggtgat     1860

gtgtaggtgc cttggccaga agaaagatct gtgttgttgt atttttttaa atttatttat     1920

ttactatatg taagtacact gcagctgtct tcagacacac cagaagaggg cgtcagatct     1980

cattagagat ggttgtgagc caccatgtgg ttgctgggat ttgaactcag gaccttcaga     2040

agagcagtca gtgctcttaa ctactgagcc atctctcaag ccccgcattg ctgtattttt     2100

aataagaaaa atgcccttat ccttccaata atgcctggag ctgtacaaat tctctgtctt     2160

agaagacttg agaaagcaga actgtaaggt cagatgcttt ctccagcctt gatgctgtgt     2220

tccaccttcc cttcctcatc cagaaaacag ttactaggga gaaaatgaga aacccatgcc     2280

agctgccctt gatgatggtt gataacggtg cttattgctt ttgatgtcat tacctctgtt     2340

agagatgaat cagagtcaga ggtccttagc tgcatccacc catttccagg gggacattct     2400

aacactgctg aacagtcagc taaaatgaga gctgtgtgtc ctagcctgat tccaggttag     2460

tcatgatgct tcctggagct gggcttttat ctaatcccag gagccatcta ggggaggctc     2520

agagctagca ggtgatcttc ctgagatggt ttcaccgtga caggtgaacc atgagccctt     2580

ccaagcaagg ccaaaggaca acattatagg aaagatttct agtattaata tgccttttct     2640

ctgtgtgtgt actgtcttgt agtgatgcta tatagacaaa tagatgattt cttatttttt     2700

gtttgtttgt ttgttttttt gtttttctgt agccctagct gtcctggaac tcactttgta     2760

aaccaggctg gcctcgatct cagaaatccg cctgcctctg cctcccgagt gctgggatta     2820

aaggtgtgca ccaccacacc ttaatgatga tcctataagt attcctaaaa ttatactagt     2880

aattattaac tcctttataa taggactgct attaaagccc tcgctgatat gaaaactaca     2940

gtgagaactc tgccagtctt cacatgtcat aattacttct gagatagaaa gcaggcattt     3000

acaacttaga acacatttct tagagctgta aaacaattaa ctagaggtca taaaagggaa     3060

tgaaagattt attgtaggtg ctaggacaga acataaaata ttgactgggc ttatctatat     3120

gaaacttcat tgttaacttt tacacaagaa ttatggtttt taactttcag tgaacctgcg     3180

gagctagtga cagaagagaa atgtctagtt agataactac tcttaatgga aattcacata     3240

aacatctgtt gccatcttct ttttgaattt atgtttaaac ttgtgaatgt ttgaattaga     3300

cactacgcga gcacatagaa aataaagaac taagcgtgaa                           3340


<210> 45
<211> 4608
<212> DNA
<213> Mus musculus

<400> 45
ggacagtgtg catcacggag cttgtggccc agactgtgcc tggcagaccc agaggaccta       60

aggcttggct ctagtggtgg tcagcacagc cctcggtggt ctgcggagcc tgatattgct      120

ttacgtaagg gctgttctgc tgtgcatctc ctgtgtctga agctattcgc catggagact      180

gctggagctc ccttctgctt ccatgtggac tccctggtac cttgctccta ctggaaggtt      240

atggggccca cgcgtgttcc caggagaacg gtgctcttcc agagggaaag gacgggcctg      300

acctaccgtg tgcctgcgtt actctgtgtg cctcccaggc ctactctgct ggccttcgcg      360

gaacagcgac ttagccctga tgactcccat gcccaccgcc tggtgctacg gaggggcacg      420

ctgaccaggg gctcagtgcg gtggggcact ctgagtgtac tggagactgc agtactggag      480

gagcacaggt ctatgaaccc ttgcccggtg ctggatgagc actctggtac catcttcctc      540

ttcttcattg ccgtgctggg ccacacaccg gaggccgtgc aaatcgccac tggcaagaac      600

gctgctcgcc tctgctgtgt gaccagctgt gacgctggcc tcacctgggg cagtgttcga      660

gatctcactg aggaagccat tggtgctgca ttgcaggact gggccacctt tgctgtgggt      720

ccgggccatg gagttcagct gcgctcgggt cgcctgcttg ttcctgctta cacctatcat      780

gtggaccgac gggaatgttt tggcaagatc tgctggacca gtccccactc cttggcattc      840

tacagtgatg atcatgggat ctcctggcat tgtggaggcc ttgtgcccaa cctacgctct      900

ggagagtgcc aactggctgc ggtagatgga gactttctct actgtaatgc tcgaagccct      960

ctgggtaacc gtgtgcaggc actgagtgct gatgaaggca cgtccttcct accaggggag     1020

ctggtgccta cattggcaga gacggctcgt ggttgccagg gtagcattgt gggcttccta     1080

gctccaccct caatcgagcc tcaggatgac cggtggacag ggagtcctag gaacacccca     1140

cattccccat gcttcaatct cagagtacag gagtcttcgg gggaaggtgc cagaggtctt     1200

cttgaacgtt ggatgcccag gttgcctctc tgctacccac agtcccggag cccagagaat     1260

catggcctag agcctgggtc agatggagat aagacatcct ggactccgga atgtcctatg     1320

tcctctgatt ccatgcttca gagccccaca tggctactat attcccaccc agcagggcgt     1380

agagctcggc tccacatggg aatctacctg agccgatccc ccttggatcc ccacagctgg     1440

acagagccct gggtgatcta tgagggcccc agtggctact ctgaccttgc ctttcttggg     1500

cctatgcctg gggcatccct ggtttttgcc tgtctgtttg agagcgggac caggacttcc     1560

tatgaagaca tttctttttg cttgttctca ctggcggatg tcctggagaa tgtgcccact     1620

ggcttagaga tgctaagtct cagggataag gctcaggggc attgctggcc ctcttgatgg     1680

cctcaccctc tcgtagccgc ctggagagga agggtagact atatagagga ggttaggggt     1740

aggtcagcat gatgctagga tggagagagc tctgtcccct cgtggatggt ggtggtgact     1800

cacccggggg gccagctgct ttctgagtgc aaatgagaaa aataaagagc tgcgctgtga     1860

cttttctttc cacatcaaag cttgggtgtc agtgctttag cttgatgctc tgatcaccat     1920

gcaaatcttc caccggcgcc ttgctcagct ttcatatccc aagggtgcct gggaggaagg     1980

caacagggac agtggacatc actgcaccac tttccacgac cctgtgtgcc aacctcagcc     2040

actttgaaac atgctgatga ctgaggtctg ttcactttct taatttcaag caggagaagc     2100

aggttgggga gccagcctcc ccagctagag gggacagaac ttgacttgag caggggggta     2160

cctcctagga cctgctccat gtgcctactt ctttaccctt ctctagagag ggctcttgtc     2220

ctgtcagagc tgttttctcc cttctcttgt tttttctttt tcaagactgt ttctctgtgt     2280

tagccctggc tgtcctggat ctcactctgt agatcaggct gaccttgagt tcaaagctcc     2340

atctgcctct acttctcaca ttactgtgat taaaggcata tactaccact gcctggtgcc     2400

cttttgtatt tcttattaaa gtcctaatgt ctgattataa aaacagtctg tgtgggctgg     2460

agtgatggct tactcagtaa agcacttgcc atggaatctg ggcaatctga gtttcatttt     2520

tagcatcctg taaaaatccc aatttgatgg tgtacttgta atgtcagcat ggagaggcag     2580

agataggtaa gttccccaag actctttgaa ccgacagctt ggcctcactg gcacattcca     2640

ggtctcagtg agagaccctg cctcaaaata caaagaaaga gctgctgaag agtgggtcag     2700

agttgacctc tgatctccgg aagtatatga tacacacccg tgcatgcact cttccttaca     2760

aaataaaaag caaaacaaaa ccccaacagg tatatggcca ttttagaaaa attagaagat     2820

ttagaaagct atacataaaa aaaaatgacc taaagaaaaa tctttactgt tctgggcact     2880

atccctatca aaccactgtg ttctttggcc aagccttggg gtggacactg ttttgaggtg     2940

ggtcctgtta tctccactag gtagtggagt tttgtgtcag actaactggg tcttaaagct     3000

gtctttaagg ccatcaggag ctactgactt gcctgcctca gcagagcata tcctgaaggt     3060

cggggttaag tctccttccc gagcgagttg ccttccagtg ggcccctgga ctcctaggtc     3120

ctcagcgctc atcagctgcc aaggactctg agggaatgtc ctctgactgt ggccccgaaa     3180

ggtaggggag ggggatgtgc ttaggcttag gacagggtcc tgtttcagtc tgccttcact     3240

gttagtagca ctgtgccaca tggcacagac tgggcgagct ttaaaggaag gaggttgata     3300

ttggttccca cttctgggga tcatggttga gcagccttgt ctgatgatgg ttgtcttgat     3360

ggtagatcgt gaggtagttg atgaaggtat gacatggtga gaaactctgt gtgtgtgtgt     3420

tattttctct gtgttctacc tatacatcta tctatgtata tatgtatcta tctatctacc     3480

tggaggctgg agagatagct tagtggttaa gaacatttgt tgttcttgca tagtcctgga     3540

tttaaatttt cagcacccac atggcagctc acaacaaccc ataaatccag tttcagagga     3600

tccaacctct gatataccat gtcagccaga gcagacacgg ctgaaggtgg tttgatcccc     3660

gtatggagag gtgacaattg ggaagagaga aagatcaact taaccatgca aggaacagga     3720

agttaaatac tgaacaggga aggtaaaggc aggaagtaga tgtagagggc aaatcaatga     3780

aacccaaaca tacccaaatt acgctaaaca cacactgaca tgccaattaa aaggacaaat     3840

tggctccact ggcaaaacca aaacagacac tgaagatcca aacagtcaca tgccaactac     3900

cgcggaggga gacagacaca gagaagaccg tgacagacac ttggacactc ttgagagtgg     3960

atgtgcagga agagagctct gccagtggag aagaaagcac tcagaagaaa gtgacagcag     4020

ctgtaaattt gtattctgct aatgttatgt tccaaagttg aaagcaaaat tgtaccaatt     4080

cataagaaca aacaggctga ctctcagttg tgactgaacg tctctcagta actgacgggg     4140

cgagcaggcc aaaggagagt cggctcagaa gggtgcatag ccacgccaaa tcaaataagc     4200

aagtacaacc ggcaggctct atttctagca caaaggggtc tgtgcctcat tctgtgcttg     4260

ggtcagagct tgggtctctc atttggatgt aagtggtgta gtggagaagc aggaaataat     4320

ccggagcgca tattttgatt ttaacataag tgctgatttg ggagggagtt ttgtcaaatt     4380

gtgtttttac aatgtttttt tttttttaaa tgatgctttt ttgtaaagtg tacaaatgtg     4440

atataagatt ggttctgcta cattcagttt ctataaaagt ggttctaaaa tattgtactg     4500

tcaatcatct catgattatt ctactgtaca cattactgac tttgtatgta ataattaata     4560

ttagaagaaa atataattta tttgaatata aaaaaaaaaa aaaaaaaa                  4608


<210> 46
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 46
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 47
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln or Leu

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 47
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Arg Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 48
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 49
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Asp Ala Ser Leu Pro Tyr Leu Gln Asp Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Arg Phe Ile Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 50
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 51
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 52
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 53
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Thr Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 54
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 55
<211> 379
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 


<210> 56
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 57
<211> 379
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 


<210> 58
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 59
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 60
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 61
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 62
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 63
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 64
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 65
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210> 66
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 67
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 68
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 69
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Asp Ala Ser Leu Pro Tyr Leu Gln Asp Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Arg Phe Ile Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 70
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 71
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 72
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 73
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Thr Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 74
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 75
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 75
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 76
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln or Leu

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 76
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Arg Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 77
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 78
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Asp Ala Ser Leu Pro Tyr Leu Gln Asp Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Arg Phe Ile Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 79
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 80
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 81
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 82
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Thr Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 83
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 84
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 84
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 85
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln or Leu

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 85
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Arg Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 86
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 86
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgta gagccagcca ggacgtgaac acagccgtgg cttggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctacagc gccagctttc tgtactccgg cgtgcccagc      180

agattcagcg gctctagaag cggcaccgac ttcaccctga ccataagcag tctgcagccc      240

gaggacttcg ccacctacta ctgtcagcag cactacacca cacctccaac ctttggccag      300

ggcaccaagg tggaaatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210> 87
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 87
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caacatcaag gacacctaca tccactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccaga atctacccca ccaacggcta caccagatac      180

gccgactctg tgaagggcag attcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgttc tagatgggga      300

ggcgacggct tctacgccat ggattattgg ggccagggca ccctggtcac cgtttcttct      360

gctagcacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgtactgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210> 88
<211> 1851
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 88
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cgggccagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgtcaagt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agagccagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccacag ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

ggcggaggtg gaagtggcgg aggcggatcc gacaaaactc acacatgccc accgtgccca     1200

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1260

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1320

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1380

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1440

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1500

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtctacacc     1560

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1620

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1680

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcac tagcaagctc     1740

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1800

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1851


<210> 89
<211> 1140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 89
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cgggccagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgtcaagt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agagccagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccacag ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140


<210> 90
<211> 618
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Thr Val Glu Lys Ser Val Val Phe Lys Ala Glu Gly Glu His Phe Thr 
1               5                   10                  15      


Asp Gln Lys Gly Asn Thr Ile Val Gly Ser Gly Ser Gly Gly Thr Thr 
            20                  25                  30          


Lys Tyr Phe Arg Ile Pro Ala Met Cys Thr Thr Ser Lys Gly Thr Ile 
        35                  40                  45              


Val Val Phe Ala Asp Ala Arg His Asn Thr Ala Ser Asp Gln Ser Phe 
    50                  55                  60                  


Ile Asp Thr Ala Ala Ala Arg Ser Thr Asp Gly Gly Lys Thr Trp Asn 
65                  70                  75                  80  


Lys Lys Ile Ala Ile Tyr Asn Asp Arg Val Asn Ser Lys Leu Ser Arg 
                85                  90                  95      


Val Met Asp Pro Thr Cys Ile Val Ala Asn Ile Gln Gly Arg Glu Thr 
            100                 105                 110         


Ile Leu Val Met Val Gly Lys Trp Asn Asn Asn Asp Lys Thr Trp Gly 
        115                 120                 125             


Ala Tyr Arg Asp Lys Ala Pro Asp Thr Asp Trp Asp Leu Val Leu Tyr 
    130                 135                 140                 


Lys Ser Thr Asp Asp Gly Val Thr Phe Ser Lys Val Glu Thr Asn Ile 
145                 150                 155                 160 


His Asp Ile Val Thr Lys Asn Gly Thr Ile Ser Ala Met Leu Gly Gly 
                165                 170                 175     


Val Gly Ser Gly Leu Gln Leu Asn Asp Gly Lys Leu Val Phe Pro Val 
            180                 185                 190         


Gln Met Val Arg Thr Lys Asn Ile Thr Thr Val Leu Asn Thr Ser Phe 
        195                 200                 205             


Ile Tyr Ser Thr Asp Gly Ile Thr Trp Ser Leu Pro Ser Gly Tyr Cys 
    210                 215                 220                 


Glu Gly Phe Gly Ser Glu Asn Asn Ile Ile Glu Phe Asn Ala Ser Leu 
225                 230                 235                 240 


Val Asn Asn Ile Arg Asn Ser Gly Leu Arg Arg Ser Phe Glu Thr Lys 
                245                 250                 255     


Asp Phe Gly Lys Thr Trp Thr Glu Phe Pro Pro Met Asp Lys Lys Val 
            260                 265                 270         


Asp Asn Arg Asn His Gly Val Gln Gly Ser Thr Ile Thr Ile Pro Ser 
        275                 280                 285             


Gly Asn Lys Leu Val Ala Ala His Ser Ser Ala Gln Asn Lys Asn Asn 
    290                 295                 300                 


Asp Tyr Thr Arg Ser Asp Ile Ser Leu Tyr Ala His Asn Leu Tyr Ser 
305                 310                 315                 320 


Gly Glu Val Lys Leu Ile Asp Asp Phe Tyr Pro Lys Val Gly Asn Ala 
                325                 330                 335     


Ser Gly Ala Gly Tyr Ser Cys Leu Ser Tyr Arg Lys Asn Val Asp Lys 
            340                 345                 350         


Glu Thr Leu Tyr Val Val Tyr Glu Ala Asn Gly Ser Ile Glu Phe Gln 
        355                 360                 365             


Asp Leu Ser Arg His Leu Pro Val Ile Lys Ser Tyr Asn Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
385                 390                 395                 400 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                405                 410                 415     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            420                 425                 430         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        435                 440                 445             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    450                 455                 460                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
465                 470                 475                 480 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                485                 490                 495     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            500                 505                 510         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        515                 520                 525             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    530                 535                 540                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
545                 550                 555                 560 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                565                 570                 575     


Leu Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            580                 585                 590         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        595                 600                 605             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615             


<210> 91
<211> 1854
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 91
acagtggaaa agtccgtggt gttcaaggcc gagggcgagc acttcaccga ccagaaaggc       60

aataccatcg tcggctctgg cagcggcggc accaccaagt actttagaat ccccgccatg      120

tgcaccacca gcaagggcac cattgtggtg ttcgccgacg ccagacacaa caccgccagc      180

gatcagagct tcatcgatac cgctgccgcc agatctaccg atggcggcaa gacctggaac      240

aagaagatcg ccatctacaa cgaccgcgtg aacagcaagc tgagcagagt gatggaccct      300

acctgcatcg tggccaacat ccagggcaga gaaaccatcc tggtcatggt cggaaagtgg      360

aacaacaacg ataagacctg gggcgcctac agagacaagg cccctgatac cgattgggac      420

ctcgtgctgt acaagagcac cgatgacggc gtgaccttca gcaaggtgga aacaaacatc      480

cacgacatcg tgaccaagaa cggcaccatc tctgccatgc tcggcggcgt tggatctggc      540

ctgcaactga atgatggcaa gctggtgttc cccgtgcaga tggtccgaac aaagaatatc      600

accaccgtgc tgaataccag cttcatctac agcaccgacg gcatcacatg gtccctgcct      660

agcggctact gtgaaggctt tggcagcgag aacaacatca tcgagttcaa cgccagcctg      720

gtcaacaaca tccggaacag cggcctgcgg agaagcttcg agacaaagga cttcggaaag      780

acgtggaccg agtttcctcc aatggacaag aaggtggaca accggaacca cggcgtgcag      840

ggcagcacaa tcacaatccc tagcggcaac aaactggtgg ccgctcactc tagcgcccag      900

aacaagaaca acgactacac cagaagcgac atcagcctgt acgcccacaa cctgtacagc      960

ggcgaagtga agctgatcga cgacttctac cccaaagtgg gcaatgccag cggagccggc     1020

tacagctgtc tgagctaccg gaaaaatgtg gacaaagaaa ccctgtacgt ggtgtacgag     1080

gccaacggca gcatcgagtt tcaggacctg agcagacatc tgcccgtgat caagagctac     1140

aacggcggag gtggaagtgg cggaggcgga tccgacaaaa ctcacacatg cccaccgtgc     1200

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1260

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1320

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1380

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1440

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1500

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtctac     1560

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1620

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1680

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct cactagcaag     1740

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1800

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1854


<210> 92
<211> 846
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Thr Val Glu Lys Ser Val Val Phe Lys Ala Glu Gly Glu His Phe 
465                 470                 475                 480 


Thr Asp Gln Lys Gly Asn Thr Ile Val Gly Ser Gly Ser Gly Gly Thr 
                485                 490                 495     


Thr Lys Tyr Phe Arg Ile Pro Ala Met Cys Thr Thr Ser Lys Gly Thr 
            500                 505                 510         


Ile Val Val Phe Ala Asp Ala Arg His Asn Thr Ala Ser Asp Gln Ser 
        515                 520                 525             


Phe Ile Asp Thr Ala Ala Ala Arg Ser Thr Asp Gly Gly Lys Thr Trp 
    530                 535                 540                 


Asn Lys Lys Ile Ala Ile Tyr Asn Asp Arg Val Asn Ser Lys Leu Ser 
545                 550                 555                 560 


Arg Val Met Asp Pro Thr Cys Ile Val Ala Asn Ile Gln Gly Arg Glu 
                565                 570                 575     


Thr Ile Leu Val Met Val Gly Lys Trp Asn Asn Asn Asp Lys Thr Trp 
            580                 585                 590         


Gly Ala Tyr Arg Asp Lys Ala Pro Asp Thr Asp Trp Asp Leu Val Leu 
        595                 600                 605             


Tyr Lys Ser Thr Asp Asp Gly Val Thr Phe Ser Lys Val Glu Thr Asn 
    610                 615                 620                 


Ile His Asp Ile Val Thr Lys Asn Gly Thr Ile Ser Ala Met Leu Gly 
625                 630                 635                 640 


Gly Val Gly Ser Gly Leu Gln Leu Asn Asp Gly Lys Leu Val Phe Pro 
                645                 650                 655     


Val Gln Met Val Arg Thr Lys Asn Ile Thr Thr Val Leu Asn Thr Ser 
            660                 665                 670         


Phe Ile Tyr Ser Thr Asp Gly Ile Thr Trp Ser Leu Pro Ser Gly Tyr 
        675                 680                 685             


Cys Glu Gly Phe Gly Ser Glu Asn Asn Ile Ile Glu Phe Asn Ala Ser 
    690                 695                 700                 


Leu Val Asn Asn Ile Arg Asn Ser Gly Leu Arg Arg Ser Phe Glu Thr 
705                 710                 715                 720 


Lys Asp Phe Gly Lys Thr Trp Thr Glu Phe Pro Pro Met Asp Lys Lys 
                725                 730                 735     


Val Asp Asn Arg Asn His Gly Val Gln Gly Ser Thr Ile Thr Ile Pro 
            740                 745                 750         


Ser Gly Asn Lys Leu Val Ala Ala His Ser Ser Ala Gln Asn Lys Asn 
        755                 760                 765             


Asn Asp Tyr Thr Arg Ser Asp Ile Ser Leu Tyr Ala His Asn Leu Tyr 
    770                 775                 780                 


Ser Gly Glu Val Lys Leu Ile Asp Asp Phe Tyr Pro Lys Val Gly Asn 
785                 790                 795                 800 


Ala Ser Gly Ala Gly Tyr Ser Cys Leu Ser Tyr Arg Lys Asn Val Asp 
                805                 810                 815     


Lys Glu Thr Leu Tyr Val Val Tyr Glu Ala Asn Gly Ser Ile Glu Phe 
            820                 825                 830         


Gln Asp Leu Ser Arg His Leu Pro Val Ile Lys Ser Tyr Asn 
        835                 840                 845     


<210> 93
<211> 2538
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 93
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caacatcaag gacacctaca tccactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccaga atctacccca ccaacggcta caccagatac      180

gccgactctg tgaagggcag attcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgttc tagatgggga      300

ggcgacggct tctacgccat ggattattgg ggccagggca ccctggtcac cgtttcttct      360

gctagcacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa ggtggcggag gatctggcgg aggtggaagc     1380

ggcggaggcg gatctacagt ggaaaagtcc gtggtgttca aggccgaggg cgagcacttc     1440

accgaccaga aaggcaatac catcgtcggc tctggcagcg gcggcaccac caagtacttt     1500

agaatccccg ccatgtgcac caccagcaag ggcaccattg tggtgttcgc cgacgccaga     1560

cacaacaccg ccagcgatca gagcttcatc gataccgctg ccgccagaag tacagacggc     1620

ggcaagacct ggaacaagaa gatcgccatc tacaacgacc gcgtgaacag caagctgagc     1680

agagtgatgg accctacctg catcgtggcc aacatccagg gcagagaaac catcctggtc     1740

atggtcggaa agtggaacaa caacgataag acctggggcg cctacagaga caaggcccct     1800

gataccgatt gggacctcgt gctgtataag agcaccgacg acggcgtgac cttcagcaag     1860

gtggaaacaa acatccacga catcgtgacc aagaacggca ccatctctgc catgctcggc     1920

ggcgttggat ctggcctgca actgaatgat ggcaagctgg tgttccccgt gcagatggtc     1980

cgaacaaaga acatcaccac cgtgctgaat accagcttca tctactccac cgacggcatc     2040

acatggtccc tgcctagcgg ctactgtgaa ggctttggca gcgagaacaa catcatcgag     2100

ttcaacgcca gcctggtcaa caacatccgg aacagcggcc tgcggagaag cttcgagaca     2160

aaggacttcg gaaagacgtg gaccgagttt cctccaatgg acaagaaggt ggacaaccgg     2220

aaccacggcg tgcagggcag cacaatcaca atccctagcg gcaacaaact ggtggccgct     2280

cactctagcg cccagaacaa gaacaacgat tacaccagaa gcgacatcag cctgtacgcc     2340

cacaacctgt actccggcga agtgaagctg atcgacgact tctaccccaa agtgggcaat     2400

gccagcggag ccggctacag ctgtctgagc taccggaaaa atgtggacaa agaaaccctg     2460

tacgtggtgt acgaggccaa cggcagcatc gagtttcagg acctgagcag acatctgccc     2520

gtgatcaaga gctacaat                                                   2538


<210> 94
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Thr Val Glu Lys Ser Val Val Phe Lys Ala Glu Gly Glu His Phe Thr 
1               5                   10                  15      


Asp Gln Lys Gly Asn Thr Ile Val Gly Ser Gly Ser Gly Gly Thr Thr 
            20                  25                  30          


Lys Tyr Phe Arg Ile Pro Ala Met Cys Thr Thr Ser Lys Gly Thr Ile 
        35                  40                  45              


Val Val Phe Ala Asp Ala Arg His Asn Thr Ala Ser Asp Gln Ser Phe 
    50                  55                  60                  


Ile Asp Thr Ala Ala Ala Arg Ser Thr Asp Gly Gly Lys Thr Trp Asn 
65                  70                  75                  80  


Lys Lys Ile Ala Ile Tyr Asn Asp Arg Val Asn Ser Lys Leu Ser Arg 
                85                  90                  95      


Val Met Asp Pro Thr Cys Ile Val Ala Asn Ile Gln Gly Arg Glu Thr 
            100                 105                 110         


Ile Leu Val Met Val Gly Lys Trp Asn Asn Asn Asp Lys Thr Trp Gly 
        115                 120                 125             


Ala Tyr Arg Asp Lys Ala Pro Asp Thr Asp Trp Asp Leu Val Leu Tyr 
    130                 135                 140                 


Lys Ser Thr Asp Asp Gly Val Thr Phe Ser Lys Val Glu Thr Asn Ile 
145                 150                 155                 160 


His Asp Ile Val Thr Lys Asn Gly Thr Ile Ser Ala Met Leu Gly Gly 
                165                 170                 175     


Val Gly Ser Gly Leu Gln Leu Asn Asp Gly Lys Leu Val Phe Pro Val 
            180                 185                 190         


Gln Met Val Arg Thr Lys Asn Ile Thr Thr Val Leu Asn Thr Ser Phe 
        195                 200                 205             


Ile Tyr Ser Thr Asp Gly Ile Thr Trp Ser Leu Pro Ser Gly Tyr Cys 
    210                 215                 220                 


Glu Gly Phe Gly Ser Glu Asn Asn Ile Ile Glu Phe Asn Ala Ser Leu 
225                 230                 235                 240 


Val Asn Asn Ile Arg Asn Ser Gly Leu Arg Arg Ser Phe Glu Thr Lys 
                245                 250                 255     


Asp Phe Gly Lys Thr Trp Thr Glu Phe Pro Pro Met Asp Lys Lys Val 
            260                 265                 270         


Asp Asn Arg Asn His Gly Val Gln Gly Ser Thr Ile Thr Ile Pro Ser 
        275                 280                 285             


Gly Asn Lys Leu Val Ala Ala His Ser Ser Ala Gln Asn Lys Asn Asn 
    290                 295                 300                 


Asp Tyr Thr Arg Ser Asp Ile Ser Leu Tyr Ala His Asn Leu Tyr Ser 
305                 310                 315                 320 


Gly Glu Val Lys Leu Ile Asp Asp Phe Tyr Pro Lys Val Gly Asn Ala 
                325                 330                 335     


Ser Gly Ala Gly Tyr Ser Cys Leu Ser Tyr Arg Lys Asn Val Asp Lys 
            340                 345                 350         


Glu Thr Leu Tyr Val Val Tyr Glu Ala Asn Gly Ser Ile Glu Phe Gln 
        355                 360                 365             


Asp Leu Ser Arg His Leu Pro Val Ile Lys Ser Tyr Asn Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
385                 390                 395                 400 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                405                 410                 415     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            420                 425                 430         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        435                 440                 445             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    450                 455                 460                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
465                 470                 475                 480 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                485                 490                 495     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            500                 505                 510         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        515                 520                 525             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    530                 535                 540                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
545                 550                 555                 560 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                565                 570                 575     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            580                 585                 590         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        595                 600                 605             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn 
        675                 680                 685             


Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly 
                725                 730                 735     


Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        755                 760                 765             


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    770                 775                 780                 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
785                 790                 795                 800 


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                805                 810                 815     


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
            820                 825                 830         


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        835                 840                 845             


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
    850                 855                 860                 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 875 


<210> 95
<211> 2625
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 95
acagtggaaa agtccgtggt gttcaaggcc gagggcgagc acttcaccga ccagaaaggc       60

aataccatcg tcggctctgg cagcggcggc accaccaagt actttagaat ccccgccatg      120

tgcaccacca gcaagggcac cattgtggtg ttcgccgacg ccagacacaa caccgccagc      180

gatcagagct tcatcgatac cgctgccgcc agatctaccg atggcggcaa gacctggaac      240

aagaagatcg ccatctacaa cgaccgcgtg aacagcaagc tgagcagagt gatggaccct      300

acctgcatcg tggccaacat ccagggcaga gaaaccatcc tggtcatggt cggaaagtgg      360

aacaacaacg ataagacctg gggcgcctac agagacaagg cccctgatac cgattgggac      420

ctcgtgctgt acaagagcac cgatgacggc gtgaccttca gcaaggtgga aacaaacatc      480

cacgacatcg tgaccaagaa cggcaccatc tctgccatgc tcggcggcgt tggatctggc      540

ctgcaactga atgatggcaa gctggtgttc cccgtgcaga tggtccgaac aaagaatatc      600

accaccgtgc tgaataccag cttcatctac agcaccgacg gcatcacatg gtccctgcct      660

agcggctact gtgaaggctt tggcagcgag aacaacatca tcgagttcaa cgccagcctg      720

gtcaacaaca tccggaacag cggcctgcgg agaagcttcg agacaaagga cttcggaaag      780

acgtggaccg agtttcctcc aatggacaag aaggtggaca accggaacca cggcgtgcag      840

ggcagcacaa tcacaatccc tagcggcaac aaactggtgg ccgctcactc tagcgcccag      900

aacaagaaca acgactacac cagaagcgac atcagcctgt acgcccacaa cctgtacagc      960

ggcgaagtga agctgatcga cgacttctac cccaaagtgg gcaatgccag cggagccggc     1020

tacagctgtc tgagctaccg gaaaaatgtg gacaaagaaa ccctgtacgt ggtgtacgag     1080

gccaacggca gcatcgagtt tcaggacctg agcagacatc tgcccgtgat caagagctac     1140

aacggcggag gtggaagtgg cggaggcgga tccgacaaaa ctcacacatg cccaccgtgc     1200

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1260

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1320

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1380

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1440

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1500

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtctac     1560

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1620

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1680

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1740

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1800

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaaggaggc     1860

ggaggatctg gcggaggtgg aagtggcgga ggcggatctg aggtgcagct ggttgaatct     1920

ggcggaggac tggttcagcc tggcggatct ctgagactgt cttgtgccgc cagcggcttc     1980

aacatcaagg acacctacat ccactgggtc cgacaggccc ctggcaaagg acttgaatgg     2040

gtcgccagaa tctaccccac caacggctac accagatacg ccgactctgt gaagggcaga     2100

ttcaccatca gcgccgacac cagcaagaac accgcctacc tgcagatgaa cagcctgaga     2160

gccgaggaca ccgccgtgta ctactgttct agatggggag gcgacggctt ctacgccatg     2220

gattattggg gccagggcac cctggtcacc gtttcttctg gcggaggagg atctggcgga     2280

ggcggaagtg gcggaggcgg atctgacatc cagatgacac agagccctag cagcctgtct     2340

gccagcgtgg gagacagagt gaccatcacc tgtagagcca gccaggacgt gaacacagcc     2400

gtggcttggt atcagcagaa gcctggcaag gcccctaagc tgctgatcta cagcgccagc     2460

tttctgtact ccggcgtgcc cagcagattc agcggctcta gaagcggcac cgacttcacc     2520

ctgaccataa gcagtctgca gcccgaggac ttcgccacct actactgtca gcagcactac     2580

accacacctc caacctttgg ccagggcacc aaggtggaaa tcaag                     2625


<210> 96
<211> 618
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Thr Val Glu Lys Ser Val Val Phe Lys Ala Glu Gly Glu His Phe Thr 
1               5                   10                  15      


Asp Gln Lys Gly Asn Thr Ile Val Gly Ser Gly Ser Gly Gly Thr Thr 
            20                  25                  30          


Lys Tyr Phe Arg Ile Pro Ala Met Cys Thr Thr Ser Lys Gly Thr Ile 
        35                  40                  45              


Val Val Phe Ala Asp Ala Arg His Asn Thr Ala Ser Asp Gln Ser Phe 
    50                  55                  60                  


Ile Asp Thr Ala Ala Ala Arg Ser Thr Asp Gly Gly Lys Thr Trp Asn 
65                  70                  75                  80  


Lys Lys Ile Ala Ile Tyr Asn Asp Arg Val Asn Ser Lys Leu Ser Arg 
                85                  90                  95      


Val Met Val Pro Thr Cys Ile Val Ala Asn Ile Gln Gly Arg Glu Thr 
            100                 105                 110         


Ile Leu Val Met Val Gly Lys Trp Asn Asn Asn Asp Lys Thr Trp Gly 
        115                 120                 125             


Ala Tyr Arg Asp Lys Ala Pro Asp Thr Asp Trp Asp Leu Val Leu Tyr 
    130                 135                 140                 


Lys Ser Thr Asp Asp Gly Val Thr Phe Ser Lys Val Glu Thr Asn Ile 
145                 150                 155                 160 


His Asp Ile Val Thr Lys Asn Gly Thr Ile Ser Ala Met Leu Gly Gly 
                165                 170                 175     


Val Gly Ser Gly Leu Gln Leu Asn Asp Gly Lys Leu Val Phe Pro Val 
            180                 185                 190         


Gln Met Val Arg Thr Lys Asn Ile Thr Thr Val Leu Asn Thr Ser Phe 
        195                 200                 205             


Ile Tyr Ser Thr Asp Gly Ile Thr Trp Ser Leu Pro Ser Gly Tyr Cys 
    210                 215                 220                 


Glu Gly Phe Gly Ser Val Asn Asn Ile Ile Glu Phe Asn Ala Ser Leu 
225                 230                 235                 240 


Val Asn Asn Ile Arg Asn Ser Gly Leu Arg Arg Ser Phe Glu Thr Lys 
                245                 250                 255     


Asp Phe Gly Lys Thr Trp Thr Glu Phe Pro Pro Met Asp Lys Lys Val 
            260                 265                 270         


Asp Asn Arg Asn His Gly Val Gln Gly Ser Thr Ile Thr Ile Pro Ser 
        275                 280                 285             


Gly Asn Lys Leu Val Ala Ala His Ser Ser Ala Gln Asn Lys Asn Asn 
    290                 295                 300                 


Asp Tyr Thr Arg Ser Asp Ile Ser Leu Tyr Ala His Asn Leu Tyr Ser 
305                 310                 315                 320 


Gly Glu Val Lys Leu Ile Asp Asp Phe Tyr Pro Lys Val Gly Asn Ala 
                325                 330                 335     


Ser Gly Ala Gly Tyr Ser Cys Leu Ser Tyr Arg Lys Asn Val Asp Lys 
            340                 345                 350         


Glu Thr Leu Tyr Val Val Tyr Glu Ala Asn Gly Ser Ile Glu Phe Gln 
        355                 360                 365             


Asp Leu Ser Arg His Leu Pro Val Ile Lys Ser Tyr Asn Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
385                 390                 395                 400 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                405                 410                 415     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            420                 425                 430         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        435                 440                 445             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    450                 455                 460                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
465                 470                 475                 480 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                485                 490                 495     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            500                 505                 510         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        515                 520                 525             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    530                 535                 540                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
545                 550                 555                 560 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                565                 570                 575     


Leu Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            580                 585                 590         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        595                 600                 605             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615             


<210> 97
<211> 1854
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 97
acagtggaaa agtccgtggt gttcaaggcc gagggcgagc acttcaccga ccagaaaggc       60

aataccatcg tcggctctgg cagcggcggc accaccaagt actttagaat ccccgccatg      120

tgcaccacca gcaagggcac cattgtggtg ttcgccgacg ccagacacaa caccgccagc      180

gatcagagct tcatcgatac cgctgccgcc agaagtacag acggcggcaa gacctggaac      240

aagaagatcg ccatctacaa cgaccgcgtg aacagcaagc tgagcagagt gatggtccct      300

acctgcatcg tggccaacat ccagggcaga gaaaccatcc tggtcatggt cggaaagtgg      360

aacaacaacg ataagacctg gggcgcctac agagacaagg cccctgatac cgattgggac      420

ctcgtgctgt ataagagcac cgacgacggc gtgaccttca gcaaggtgga aacaaacatc      480

cacgacatcg tgaccaagaa cggcaccatc tctgccatgc tcggcggcgt tggatctggc      540

ctgcaactga atgatggcaa gctggtgttc cccgtgcaga tggtccgaac aaagaacatc      600

accaccgtgc tgaataccag cttcatctac tccaccgacg gcatcacatg gtccctgcct      660

agcggctact gtgaaggctt tggcagcgtg aacaacatca tcgagttcaa cgccagcctg      720

gtcaacaaca tccggaacag cggcctgcgg agaagcttcg agacaaagga cttcggaaag      780

acgtggaccg agtttcctcc aatggacaag aaggtggaca accggaacca cggcgtgcag      840

ggcagcacaa tcacaatccc tagcggcaac aaactggtgg ccgctcactc tagcgcccag      900

aacaagaaca acgattacac cagaagcgac atcagcctgt acgcccacaa cctgtactcc      960

ggcgaagtga agctgatcga cgacttctac cccaaagtgg gcaatgccag cggagccggc     1020

tacagctgtc tgagctaccg gaaaaatgtg gacaaagaaa ccctgtacgt ggtgtacgag     1080

gccaacggca gcatcgagtt tcaggacctg agcagacatc tgcccgtgat caagagctac     1140

aatggcggag gtggaagtgg cggaggcgga tccgacaaaa ctcacacatg cccaccgtgc     1200

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1260

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1320

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1380

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1440

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1500

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtctac     1560

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1620

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1680

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct cactagcaag     1740

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1800

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1854


<210> 98
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser Ser 
    370                 375                 380                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
385                 390                 395                 400 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                405                 410                 415     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            420                 425                 430         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        435                 440                 445             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    450                 455                 460                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
465                 470                 475                 480 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                485                 490                 495     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            500                 505                 510         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        515                 520                 525             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    530                 535                 540                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
                565                 570                 575     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            580                 585                 590         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        595                 600                 605             


Pro Gly Lys 
    610     


<210> 99
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser Ser 
    370                 375                 380                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
385                 390                 395                 400 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                405                 410                 415     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            420                 425                 430         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        435                 440                 445             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    450                 455                 460                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
465                 470                 475                 480 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                485                 490                 495     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            500                 505                 510         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        515                 520                 525             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    530                 535                 540                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
                565                 570                 575     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            580                 585                 590         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        595                 600                 605             


Pro Gly Lys 
    610     


<210> 100
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 101
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 101
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 102
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 103
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 104
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 105
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 106
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 107
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
Asp Ala Ser Leu Pro Tyr Leu Gln Asp Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Arg Phe Ile Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 108
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 109
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 109
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 110
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 110
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 111
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 111
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Thr Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 112
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 112
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 113
<211> 616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 113
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615     


<210> 114
<211> 616
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 114
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615     


<210> 115
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 115
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 116
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 116
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 117
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 117
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 118
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 118
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 119
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 119
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 120
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 121
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 121
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 122
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 122
Asp Ala Ser Leu Pro Tyr Leu Gln Asp Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Arg Phe Ile Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 123
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 123
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 124
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 124
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 125
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 125
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 126
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 126
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Thr Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 127
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 128
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 128
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser Ser 
    370                 375                 380                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
385                 390                 395                 400 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                405                 410                 415     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            420                 425                 430         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        435                 440                 445             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    450                 455                 460                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
465                 470                 475                 480 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                485                 490                 495     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            500                 505                 510         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        515                 520                 525             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    530                 535                 540                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                565                 570                 575     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            580                 585                 590         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        595                 600                 605             


Pro Gly Lys 
    610     


<210> 129
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 129
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser Ser 
    370                 375                 380                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
385                 390                 395                 400 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                405                 410                 415     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            420                 425                 430         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        435                 440                 445             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    450                 455                 460                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
465                 470                 475                 480 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                485                 490                 495     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            500                 505                 510         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        515                 520                 525             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    530                 535                 540                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                565                 570                 575     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            580                 585                 590         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        595                 600                 605             


Pro Gly Lys 
    610     


<210> 130
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 130
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 131
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 131
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 132
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 132
Ala Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 133
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 133
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 134
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 134
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 135
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 135
Met Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 136
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 136
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 137
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 137
Asp Ala Ser Leu Pro Tyr Leu Gln Asp Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Arg Phe Ile Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 138
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 139
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 140
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 141
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Thr Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 142
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 143
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGSGGGGS" or "EPKSS"

<400> 143
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 144
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln or Leu

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu or Lys

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, or Pro

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser or Arg

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp or Lys

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGSGGGGS" or "EPKSS" 

<400> 144
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Arg Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 145
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 145
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 146
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 146
Glu Pro Lys Ser Ser 
1               5   


<210> 147
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 147
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 148
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 148
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 149
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 149
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ala Arg Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 150
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 150
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ala Arg Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 151
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ala Arg Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 152
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 152
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ala Arg Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 153
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 153
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ala Arg Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 154
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 154
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 155
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 155
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 156
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 156
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 157
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 157
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 158
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 158
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 159
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 159
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 160
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 160
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 161
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 161
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 162
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 162
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 163
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 163
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 164
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS"

<400> 164
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Xaa Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 165
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Asp or Pro

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Gln or Pro

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Ala, Cys, Asn, Ser, or Thr

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Glu or Pro

<220>
<221> MOD_RES
<222> (239)..(239)
<223> His or Pro

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Leu, Asp, Asn, or Tyr

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Arg, Ala, Asp, Leu, Gln, or Tyr

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Val, Ile, or Lys

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu, Lys, or Pro

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Ser or Cys

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Leu, Asp, Phe, Gln, or Thr

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Val or Phe

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS"

<400> 165
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Xaa 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Xaa Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Xaa Xaa Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Xaa Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Xaa Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Arg Xaa Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Xaa Gln Xaa Val Lys Lys Leu Xaa Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 166
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 166
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ala Arg Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 167
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 167
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 168
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 168
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 169
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 169
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 170
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 170
Asp Ala Ser Leu Pro Tyr Leu Gln Asp Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Arg Phe Ile Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 171
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 171
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 172
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 172
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 173
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 173
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Ser Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 174
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 174
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Thr Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 175
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 175
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Asn Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Ala Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Arg Lys Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 176
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 176
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ala Arg Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 177
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 177
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 178
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 178
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 179
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS"

<400> 179
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Xaa Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 180
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Asp or Pro

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Gln or Pro

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Ala, Cys, Asn, Ser, or Thr

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Glu or Pro

<220>
<221> MOD_RES
<222> (239)..(239)
<223> His or Pro

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Leu, Asp, Asn, or Tyr

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Arg, Ala, Asp, Leu, Gln, or Tyr

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Val, Ile, or Lys

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu, Lys, or Pro

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Ser or Cys

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Leu, Asp, Phe, Gln, or Thr

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Val or Phe

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met,
       Asn, Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met,
       Asn, Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS"

<400> 180
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Xaa 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Xaa Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Xaa Xaa Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Xaa Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Xaa Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Arg Xaa Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Xaa Gln Xaa Val Lys Lys Leu Xaa Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 181
<211> 1140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 181
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cgggccagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140


<210> 182
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Asp or Pro

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Gln or Pro

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Ala, Cys, Asn, Ser, or Thr

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Glu or Pro

<220>
<221> MOD_RES
<222> (239)..(239)
<223> His or Pro

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Leu, Asp, Asn, or Tyr

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Arg, Ala, Asp, Leu, Gln, or Tyr

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Val, Ile, or Lys

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu, Lys, or Pro

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Ser or Cys

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Leu, Asp, Phe, Gln, or Thr

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Val or Phe

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 182
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Xaa 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Xaa Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Xaa Xaa Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Xaa Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Xaa Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Arg Xaa Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Xaa Gln Xaa Val Lys Lys Leu Xaa Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 183
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 183
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Xaa Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 184
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 184
Gly Gly Gly Gly Ser 
1               5   


<210> 185
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 185
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 186
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 186
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cgggccagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agagccagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg tactgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 187
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 187
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 188
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 188
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cgggccagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg tactgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 189
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 189
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 190
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 190
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caacatcaag gacacctaca tccactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccaga atctacccca ccaacggcta caccagatac      180

gccgactctg tgaagggcag attcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgttc tagatgggga      300

ggcgacggct tctacgccat ggattattgg ggccagggca ccctggtcac cgtttcttct      360

gctagcacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcact agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210> 191
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 191
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 192
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 192
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 193
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 193
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 194
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 194
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 195
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 195
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 196
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 196
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 197
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 197
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 198
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 198
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 199
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Ala or Arg

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Asp or Pro

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Gln or Pro

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Ala, Cys, Asn, Ser, or Thr

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Glu or Pro

<220>
<221> MOD_RES
<222> (239)..(239)
<223> His or Pro

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Leu, Asp, Asn, or Tyr

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Arg, Ala, Asp, Leu, Gln, or Tyr

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Val, Ile, or Lys

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu, Lys, or Pro

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Ser or Cys

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Leu, Asp, Phe, Gln, or Thr

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Val or Phe

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 199
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Xaa Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Xaa 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Xaa Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Xaa Xaa Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Xaa Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Xaa Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Arg Xaa Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Xaa Gln Xaa Val Lys Lys Leu Xaa Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 200
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Arg or Ala

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<400> 200
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Xaa Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Xaa Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210> 201
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Ala or Arg

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Asp or Pro

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Gln or Pro

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Ala, Cys, Asn, Ser, or Thr

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Glu or Pro

<220>
<221> MOD_RES
<222> (239)..(239)
<223> His or Pro

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Leu, Asp, Asn, or Tyr

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Arg, Ala, Asp, Leu, Gln, or Tyr

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Val, Ile, or Lys

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu, Lys, or Pro

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Ser or Cys

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Leu, Asp, Phe, Gln, or Thr

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Val or Phe

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS" 

<400> 201
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Xaa Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Xaa 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Xaa Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Xaa Xaa Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Xaa Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Xaa Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Arg Xaa Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Xaa Gln Xaa Val Lys Lys Leu Xaa Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 202
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Arg or Ala

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS" ,

<400> 202
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Xaa Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Xaa Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 203
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 203
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 204
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 204
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 205
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 205
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 206
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 206
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 207
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 207
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 208
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 208
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 209
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 209
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210> 210
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 210
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 211
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 211
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 212
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 212
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 213
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 213
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 214
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 214
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 215
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 215
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 216
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 216
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 217
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 217
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 218
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 218
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 219
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 219
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacgccagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctaag cttgtctccg ggtaaa                               1836


<210> 220
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 220
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Glu 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 221
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 221
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gaggaacagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 222
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 222
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Cys Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Cys Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 223
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 223
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tgtgtaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctccttgt cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 224
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 224
Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly Ala 
1               5                   10                  15      


His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln Ser 
            20                  25                  30          


Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His Ala 
        35                  40                  45              


Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His Gln 
    50                  55                  60                  


Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp Gly 
65                  70                  75                  80  


His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly Thr 
                85                  90                  95      


Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln Gln 
            100                 105                 110         


Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr Ser 
        115                 120                 125             


Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp Ala 
    130                 135                 140                 


Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly Pro 
145                 150                 155                 160 


Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val Pro 
                165                 170                 175     


Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro Ser 
            180                 185                 190         


Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg Gly 
        195                 200                 205             


His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val Glu 
    210                 215                 220                 


Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu Arg 
225                 230                 235                 240 


Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln Glu 
                245                 250                 255     


Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys Gln 
            260                 265                 270         


Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg Ala 
    290                 295                 300                 


Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala Trp 
305                 310                 315                 320 


Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp Leu 
                325                 330                 335     


Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys Leu 
            340                 345                 350         


Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr Leu 
        355                 360                 365             


Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser Ser 
    370                 375                 380                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
385                 390                 395                 400 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                405                 410                 415     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            420                 425                 430         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        435                 440                 445             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    450                 455                 460                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
465                 470                 475                 480 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                485                 490                 495     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            500                 505                 510         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        515                 520                 525             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    530                 535                 540                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
545                 550                 555                 560 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                565                 570                 575     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            580                 585                 590         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        595                 600                 605             


Pro Gly Lys 
    610     


<210> 225
<211> 1833
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 225
gcatctctgc cttacctgca gaaagaaagc gtgttccagt ctggcgccca cgcctacaga       60

attcccgctc tgctgtatct gccaggccag cagtctctgc tggctttcgc tgaacagcgg      120

cggagcaaga aggatgagca cgccgaactg atcgtgctgc ggagaggcga ttacgacgcc      180

ggcacacatc aggtgcagtg gcaggctcaa gaggtggtgg ctcaggctag actggacggc      240

cacagatcta tgaacccctg tcctctgtac gatgaacaga ccggcacact gtttctgttc      300

tttatcgcta tccccggcca agtgaccgag cagcagcagc tgcagacaag agccaacgtg      360

accagactgt gttacgtgac ctccaccgac cacggcagaa cctggtctag ccctagagat      420

ctgaccgacg ccgccatcgg acctgcctat agagagtggt ccaccttcgc cgttggacct      480

ggacactgtc tccagctgca cgacagggct agatctctgg tggtgcctgc ctacgcctat      540

agaaagctgc accccaaaca gcggcctatt cctagcgcct tctgctttct gagccacgat      600

cacggcagga catgggccag aggacatttc gtggcccagg acacactgga atgccaggtg      660

gccgaagtgg aaaccggcga gcagagagtc gtgaccctga acgccagatc tcacctgaga      720

ttcagagtgc aggcccagag cacaaacgac ggcctggatt tccaagagag ccagctggtc      780

aagaaactgg tggaacctcc tccaaccggc tgtcagggaa gcgtgatcag ctttccatct      840

cctagaagcg gccctggctc tcctgctcag tggctgctgt atacacaccc cacacacagc      900

tggcagagag ccgatctggg cgcctacctg aatcctagac ctcctgctcc tgaggcttgg      960

agcgaacctg ttctgctggc caagggcagc gctgcctaca gcgatctgca gtctatgggc     1020

acaggccctg atggcagccc tctgtttggc tgtctgtacg aggccaacga ctacgaagag     1080

atcgtgttcc tgatgttcac cctgaagcag gcctttccag ccgagtacct gcctcaagag     1140

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1200

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1260

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1320

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1380

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1440

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1500

tccaaagcca aagggcagcc ccgagaacca caggtctaca ccctgccccc atcccgggag     1560

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1620

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1680

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1740

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1800

acgcagaaga gcctctccct gtctccgggt aaa                                  1833


<210> 226
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 226
Asp Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 227
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 227
gatgcatctc tgcctgtgct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 228
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 228
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 229
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 229
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cgggccagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 230
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 230
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 231
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 231
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gcccctacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 232
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 232
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 233
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 233
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgccc agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 234
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 234
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 235
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 235
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgtcaggt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 236
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 236
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 237
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 237
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccat ccagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 238
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 238
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 239
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 239
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agagccagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 240
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 241
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 241
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccacag ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 242
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 242
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210> 243
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 243
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agctgtgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 244
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 245
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 245
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caacatcaag gacacctaca tccactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccaga atctacccca ccaacggcta caccagatac      180

gccgactctg tgaagggcag attcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgttc tagatgggga      300

ggcgacggct tctacgccat ggattattgg ggccagggca ccctggtcac cgtttcttct      360

gctagcacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      480

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcacc agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210> 246
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 246
gatgcatctc tgccttacct gcagaaagaa agcgtgttcc agtctggcgc ccacgcctac       60

agaattcccg ctctgctgta tctgccaggc cagcagtctc tgctggcttt cgctgaacag      120

cggcggagca agaaggatga gcacgccgaa ctgatcgtgc tgcggagagg cgattacgac      180

gccggcacac atcaggtgca gtggcaggct caagaggtgg tggctcaggc tagactggac      240

ggccacagat ctatgaaccc ctgtcctctg tacgatgaac agaccggcac actgtttctg      300

ttctttatcg ctatccccgg ccaagtgacc gagcagcagc agctgcagac aagagccaac      360

gtgaccagac tgtgttacgt gacctccacc gaccacggca gaacctggtc tagccctaga      420

gatctgaccg acgccgccat cggacctgcc tatagagagt ggtccacctt cgccgttgga      480

cctggacact gtctccagct gcacgacagg gctagatctc tggtggtgcc tgcctacgcc      540

tatagaaagc tgcaccccaa acagcggcct attcctagcg ccttctgctt tctgagccac      600

gatcacggca ggacatgggc cagaggacat ttcgtggccc aggacacact ggaatgccag      660

gtggccgaag tggaaaccgg cgagcagaga gtcgtgaccc tgaacgccag atctcacctg      720

agattcagag tgcaggccca gagcacaaac gacggcctgg atttccaaga gagccagctg      780

gtcaagaaac tggtggaacc tcctccaacc ggctgtcagg gaagcgtgat cagctttcca      840

tctcctagaa gcggccctgg ctctcctgct cagtggctgc tgtatacaca ccccacacac      900

agctggcaga gagccgatct gggcgcctac ctgaatccta gacctcctgc tcctgaggct      960

tggagcgaac ctgttctgct ggccaagggc agcgctgcct acagcgatct gcagtctatg     1020

ggcacaggcc ctgatggcag ccctctgttt ggctgtctgt acgaggccaa cgactacgaa     1080

gagatcgtgt tcctgatgtt caccctgaag caggcctttc cagccgagta cctgcctcaa     1140

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1200

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1260

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1320

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1380

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1440

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1500

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1560

gaggagatga ccaagaacca ggtcagcctg tactgcctgg tcaaaggctt ctatcccagc     1620

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1680

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1740

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1800

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1836


<210> 247
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Arg or Ala

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu, or Lys

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS"

<400> 247
Xaa Ala Ser Leu Pro Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Xaa Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Xaa Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Xaa Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 248
<211> 874
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Arg, Asn, Asp, Gln, Glu, Gly, His, Leu, Lys, Met, Phe, Thr,
      Val, or not present

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala or Lys

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asn or Leu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pro or His

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Phe, Trp, Tyr or Val

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Lys or Asp

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Ala or Arg

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Lys, Arg, or Glu

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Ala, Arg, or Glu

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Leu or Met

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Pro, Asn, Asp, His, Glu, Gly, Ser or Thr

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Gln or His

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Arg or Lys

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Asp or Pro

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Ala, Glu or Lys

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Gly or Asp

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Gln or His

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Gln, Arg, or Lys

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Ala, Cys, Ile, Ser, Val, or Leu

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln, Leu, Glu, Phe, His, Ile, Leu, or Tyr

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Cys or Gly

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Ala or Gly

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Arg, Ile, or Lys

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Gln or Pro

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Arg or Pro

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Ala, Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Ala, Cys, Asn, Ser, or Thr

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Leu, Ala, or Val

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Glu or Pro

<220>
<221> MOD_RES
<222> (239)..(239)
<223> His or Pro

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Leu, Asp, Asn, or Tyr

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Arg, Ala, Asp, Leu, Gln, or Tyr

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser,
      Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Val, Ile, or Lys

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Thr or Ala

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Asp or Gly

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Glu, Lys, or Pro

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Ser or Cys

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Leu, Asp, Phe, Gln, or Thr

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Val or Phe

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Gln, Ala, His, Phe, Pro, Ser, or Thr

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Cys or Val

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Trp or Arg

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Ser, Arg, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Thr, Val, Trp, or Tyr

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Trp, Lys, Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
      Pro, Gln, Arg, Ser, Thr, Val, or Tyr

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Lys or Val

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Ala, Cys, Ser, or Val

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Cys, Leu, or Val

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Val or Arg

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Leu, Gln, His, Ile, Lys, or Ser

<220>
<221> MOD_RES
<222> (381)..(390)
<223> This region may encompass one of the following sequences:
      "GGGGS" or "GGGGSGGGGS" or "EPKSS"

<400> 248
Xaa Xaa Ser Xaa Xaa Xaa Leu Gln Xaa Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Xaa Ser Xaa Xaa Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Xaa Arg Arg Gly Asp Tyr Asp Ala Xaa Thr His 
    50                  55                  60                  


Gln Val Gln Trp Xaa Ala Gln Glu Val Val Ala Gln Ala Xaa Leu Xaa 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Xaa Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Xaa Xaa Val Thr Glu Xaa 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Xaa Xaa Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Xaa Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Xaa Leu Gln Leu His Asp Xaa Xaa Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Xaa Xaa Xaa Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Xaa Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Xaa Gln Asp Thr Xaa Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Xaa Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Arg Xaa Gln Ala Gln Ser Xaa Asn Xaa Gly Leu Asp Phe Gln 
                245                 250                 255     


Xaa Xaa Gln Xaa Val Lys Lys Leu Xaa Glu Pro Pro Pro Xaa Gly Xaa 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Xaa Leu Leu Tyr Thr His Pro Thr His Xaa Xaa Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Xaa Leu Leu Ala Lys Gly Ser Xaa Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Xaa 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Xaa Phe Xaa Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
625                 630                 635                 640 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                645                 650                 655     


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
            660                 665                 670         


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
        675                 680                 685             


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
    690                 695                 700                 


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    770                 775                 780                 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
785                 790                 795                 800 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                805                 810                 815     


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            820                 825                 830         


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        835                 840                 845             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
    850                 855                 860                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
865                 870                 


<210> 249
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 249
Asp Ala Ser Leu Pro Tyr Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Arg Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Gly Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Glu Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Tyr Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu His Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Lys Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Phe Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Thr Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Ala Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln Glu Pro Lys Ser 
    370                 375                 380                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
385                 390                 395                 400 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                405                 410                 415     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            420                 425                 430         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        435                 440                 445             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    450                 455                 460                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
625                 630                 635                 640 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
                645                 650                 655     


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            660                 665                 670         


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
        675                 680                 685             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
    690                 695                 700                 


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
705                 710                 715                 720 


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        755                 760                 765             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    770                 775                 780                 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
785                 790                 795                 800 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
                805                 810                 815     


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
            820                 825                 830         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        835                 840                 845             


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
    850                 855                 860                 


Lys Val Glu Ile Lys 
865                 


<210> 250
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      10xHis tag

<400> 250
His His His His His His His His His His 
1               5                   10  


<210> 251
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(15) 
<223> This sequence may encompass 1-5 "Gly Gly Pro"
      repeating units

<400> 251
Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro 
1               5                   10                  15  


<210> 252
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(25) 
<223> This sequence may encompass 1-5 "Gly Gly Gly Gly Ser"
      repeating units

<400> 252
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 253
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 253
His His His His His His 
1               5       


<210> 254
<211> 5
<212> PRT
<213> Homo sapiens

<400> 254
Leu His Pro Ile Gln 
1               5   


<210> 255
<211> 10
<212> PRT
<213> Homo sapiens

<400> 255
Thr Phe Ala Val Gly Pro Gly His Cys Leu 
1               5                   10  


<210> 256
<211> 7
<212> PRT
<213> Petromyzon marinus

<400> 256
Cys His Cys Arg Ile Val Met 
1               5           


<210> 257
<211> 7
<212> PRT
<213> Carlito syrichta

<400> 257
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 258
<211> 7
<212> PRT
<213> Saccoglossus kowalevskii

<400> 258
Cys Arg Cys Arg Ile Ile Ala 
1               5           


<210> 259
<211> 7
<212> PRT
<213> Lygus hesperus

<400> 259
His Pro Thr His Gln Gly Val 
1               5           


<210> 260
<211> 7
<212> PRT
<213> Rattus norvegicus

<400> 260
Ile Gly Ala Arg Val Gln Ala 
1               5           


<210> 261
<211> 7
<212> PRT
<213> Branchiostoma floridae

<400> 261
Cys His Cys Lys Ala Phe Leu 
1               5           


<210> 262
<211> 7
<212> PRT
<213> Alces americanus

<400> 262
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 263
<211> 7
<212> PRT
<213> Pan troglodytes

<400> 263
Leu Gln Ala Arg Val Gln Ala 
1               5           


<210> 264
<211> 7
<212> PRT
<213> Xenopus tropicalis

<400> 264
Lys His Phe Arg Val Glu Ala 
1               5           


<210> 265
<211> 7
<212> PRT
<213> Gallus gallus

<400> 265
Arg Gly Ala Arg Ile Gln Ala 
1               5           


<210> 266
<211> 7
<212> PRT
<213> Anolis carolinensis

<400> 266
Asp Lys Ser Arg Ala Glu Ala 
1               5           


<210> 267
<211> 7
<212> PRT
<213> Ornithorhynchus anatinus

<400> 267
Arg Gly Ser Arg Val Gln Ala 
1               5           


<210> 268
<211> 7
<212> PRT
<213> Branchiostoma floridae

<400> 268
Cys Ser Cys Lys Ala Phe Met 
1               5           


<210> 269
<211> 7
<212> PRT
<213> Strongylocentrotus purpuratus

<400> 269
Cys His Cys Arg Leu Gln Ser 
1               5           


<210> 270
<211> 7
<212> PRT
<213> Strongylocentrotus purpuratus

<400> 270
Cys Asn Cys Arg Ile Gln Ala 
1               5           


<210> 271
<211> 7
<212> PRT
<213> Otolemur garnettii

<400> 271
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 272
<211> 7
<212> PRT
<213> Alligator sinensis

<400> 272
Arg Gly Ala Arg Val Gln Ala 
1               5           


<210> 273
<211> 7
<212> PRT
<213> Chlorocebus sabaeus

<400> 273
Leu Arg Ala Arg Ile Gln Ala 
1               5           


<210> 274
<211> 7
<212> PRT
<213> Anas platyrhynchos platyrhynchos

<400> 274
Lys Gly Ala Arg Ile Gln Ala 
1               5           


<210> 275
<211> 7
<212> PRT
<213> Latimeria chalumnae

<400> 275
Leu Gly Ser Arg Val Gln Ala 
1               5           


<210> 276
<211> 7
<212> PRT
<213> Cricetulus griseus

<400> 276
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 277
<211> 7
<212> PRT
<213> Latimeria chalumnae

<400> 277
Leu Gly Ser Arg Val Gln Ala 
1               5           


<210> 278
<211> 7
<212> PRT
<213> Lonchura striata domestica

<400> 278
Arg Gly Ala Arg Ile Gln Ala 
1               5           


<210> 279
<211> 7
<212> PRT
<213> Callithrix jacchus

<400> 279
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 280
<211> 7
<212> PRT
<213> Ovis aries

<400> 280
His Gln Ala Arg Val Gln Ala 
1               5           


<210> 281
<211> 7
<212> PRT
<213> Ophiophagus hannah

<400> 281
Asp Arg Tyr Arg Val Glu Ala 
1               5           


<210> 282
<211> 7
<212> PRT
<213> Equus caballus

<400> 282
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 283
<211> 7
<212> PRT
<213> Homo sapiens

<400> 283
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 284
<211> 7
<212> PRT
<213> Xenopus tropicalis

<400> 284
Cys Gly Lys Arg Ile Glu Ala 
1               5           


<210> 285
<211> 7
<212> PRT
<213> Branchiostoma floridae

<400> 285
His Ala Arg Arg Gln Gln Ser 
1               5           


<210> 286
<211> 6
<212> PRT
<213> Karenia brevis

<400> 286
Phe Phe Arg Thr Arg Thr 
1               5       


<210> 287
<211> 7
<212> PRT
<213> Patagioenas fasciata monilis

<400> 287
Arg Gly Ala Arg Ile Gln Ala 
1               5           


<210> 288
<211> 7
<212> PRT
<213> Saccoglossus kowalevskii

<400> 288
Cys Lys Cys Arg Ile Phe Ser 
1               5           


<210> 289
<211> 7
<212> PRT
<213> Petromyzon marinus

<400> 289
Cys Arg Cys Arg Ile Val Ile 
1               5           


<210> 290
<211> 7
<212> PRT
<213> Anolis carolinensis

<400> 290
Glu Gln Cys Arg Ala Glu Ala 
1               5           


<210> 291
<211> 7
<212> PRT
<213> Saccoglossus kowalevskii

<400> 291
Cys Ser Cys Arg Ile Ile Thr 
1               5           


<210> 292
<211> 7
<212> PRT
<213> Petromyzon marinus

<400> 292
His Glu Phe Arg Val Gln Ala 
1               5           


<210> 293
<211> 7
<212> PRT
<213> Patagioenas fasciata monilis

<400> 293
Arg Gly Ala Arg Ile Gln Ala 
1               5           


<210> 294
<211> 7
<212> PRT
<213> Branchiostoma floridae

<400> 294
Cys Asn Cys Lys Met Ile Met 
1               5           


<210> 295
<211> 7
<212> PRT
<213> Papio anubis

<400> 295
Leu Arg Ala Arg Ile Gln Ala 
1               5           


<210> 296
<211> 7
<212> PRT
<213> Sarcophilus harrisii

<400> 296
Leu Gly Arg Arg Val Gln Ala 
1               5           


<210> 297
<211> 7
<212> PRT
<213> Monodelphis domestica

<400> 297
His Lys Leu Arg Val Gln Ala 
1               5           


<210> 298
<211> 7
<212> PRT
<213> Papio anubis

<400> 298
Leu Arg Ala Arg Ile Gln Ala 
1               5           


<210> 299
<211> 7
<212> PRT
<213> Ailuropoda melanoleuca

<400> 299
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 300
<211> 7
<212> PRT
<213> Anolis carolinensis

<400> 300
Asp Arg Tyr Arg Ala Glu Ala 
1               5           


<210> 301
<211> 7
<212> PRT
<213> Mesocricetus auratus 

<400> 301
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 302
<211> 7
<212> PRT
<213> Alligator mississippiensis

<400> 302
Arg Gly Ala Arg Val Gln Ala 
1               5           


<210> 303
<211> 7
<212> PRT
<213> Mustela putorius furo

<400> 303
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 304
<211> 7
<212> PRT
<213> Castor fiber

<400> 304
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 305
<211> 7
<212> PRT
<213> Strongylocentrotus purpuratus

<400> 305
Gln Ala Thr Arg Gln Glu Ser 
1               5           


<210> 306
<211> 7
<212> PRT
<213> Paracentrotus lividus

<400> 306
Lys Lys Pro His Pro Arg Ser 
1               5           


<210> 307
<211> 7
<212> PRT
<213> Ictidomys tridecemlineatus

<400> 307
Arg Gly Ala Arg Val Gln Ala 
1               5           


<210> 308
<211> 7
<212> PRT
<213> Meleagris gallopavo

<400> 308
Lys Gly Ala Arg Ile Gln Ala 
1               5           


<210> 309
<211> 7
<212> PRT
<213> Cavia porcellus

<400> 309
Gln Lys Ala Arg Val Gln Ala 
1               5           


<210> 310
<211> 7
<212> PRT
<213> Sus scrofa

<400> 310
Leu Gln Ala Arg Val Gln Ala 
1               5           


<210> 311
<211> 7
<212> PRT
<213> Canis lupus familiaris

<400> 311
Arg Arg Ala Arg Val Gln Ala 
1               5           


<210> 312
<211> 7
<212> PRT
<213> Strongylocentrotus purpuratus

<400> 312
Cys Ser Cys Arg Ile Gln Ala 
1               5           


<210> 313
<211> 7
<212> PRT
<213> Felis catus

<400> 313
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 314
<211> 7
<212> PRT
<213> Taeniopygia guttata 

<400> 314
Arg Gly Cys Arg Ala Val Ala 
1               5           


<210> 315
<211> 7
<212> PRT
<213> Taeniopygia guttata

<400> 315
Arg Gly Ala Arg Ile Gln Ala 
1               5           


<210> 316
<211> 7
<212> PRT
<213> Erinaceus europaeus

<400> 316
Trp Gly Ala Arg Ile Gln Ala 
1               5           


<210> 317
<211> 7
<212> PRT
<213> Mus musculus

<400> 317
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 318
<211> 7
<212> PRT
<213> Mus musculus

<400> 318
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 319
<211> 7
<212> PRT
<213> Mus musculus

<400> 319
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 320
<211> 7
<212> PRT
<213> Mus musculus

<400> 320
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 321
<211> 7
<212> PRT
<213> Xenopus tropicalis

<400> 321
Gly Lys Lys Arg Ile Glu Ala 
1               5           


<210> 322
<211> 7
<212> PRT
<213> Nomascus leucogenys

<400> 322
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 323
<211> 7
<212> PRT
<213> Strongylocentrotus purpuratus

<400> 323
Gln Gln Thr Arg Ala Ala Ile 
1               5           


<210> 324
<211> 7
<212> PRT
<213> Macaca mulatta

<400> 324
Leu Arg Ala Arg Ile Gln Ala 
1               5           


<210> 325
<211> 7
<212> PRT
<213> Oryctolagus cuniculus

<400> 325
Gln Gly Ser Arg Val Gln Ala 
1               5           


<210> 326
<211> 7
<212> PRT
<213> Gallus gallus

<400> 326
Leu Gly Phe Arg Val Gln Ala 
1               5           


<210> 327
<211> 7
<212> PRT
<213> Anolis carolinensis

<400> 327
His Lys Tyr Arg Ala Gly Ala 
1               5           


<210> 328
<211> 7
<212> PRT
<213> Rattus norvegicus

<400> 328
Ile Gly Ala Arg Val Gln Ala 
1               5           


<210> 329
<211> 7
<212> PRT
<213> Ictidomys tridecemlineatus

<400> 329
Arg Gly Ala Arg Val Gln Ala 
1               5           


<210> 330
<211> 7
<212> PRT
<213> Dipodomys ordii

<400> 330
Arg Gly Ala Arg Val Gln Ala 
1               5           


<210> 331
<211> 7
<212> PRT
<213> Bos taurus

<400> 331
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 332
<211> 5
<212> PRT
<213> Karenia brevis

<400> 332
Gly Arg Gly Val Ala 
1               5   


<210> 333
<211> 7
<212> PRT
<213> Anolis carolinensis

<400> 333
Cys Ser Cys Arg Ile Val Ile 
1               5           


<210> 334
<211> 7
<212> PRT
<213> Myotis lucifugus

<400> 334
Arg Gly Ala Arg Ile Gln Ala 
1               5           


<210> 335
<211> 7
<212> PRT
<213> Gorilla gorilla gorilla

<400> 335
Leu Arg Ala Arg Val Gln Ala 
1               5           


<210> 336
<211> 7
<212> PRT
<213> Ficedula albicollis

<400> 336
Arg Gly Ala Arg Ile Gln Ala 
1               5           


<210> 337
<211> 7
<212> PRT
<213> Loxodonta africana

<400> 337
Arg Arg Ala Arg Val Gln Ala 
1               5           


<210> 338
<211> 7
<212> PRT
<213> Mus musculus

<400> 338
Leu Gly Ala Arg Val Gln Ala 
1               5           


<210> 339
<211> 6
<212> PRT
<213> Homo sapiens

<400> 339
Leu Arg Ala Arg Val Gln 
1               5       


<210> 340
<211> 6
<212> PRT
<213> Homo sapiens

<400> 340
Leu Arg Cys Arg Val Gln 
1               5       


<210> 341
<211> 6
<212> PRT
<213> Homo sapiens

<400> 341
Leu Arg Ala Lys Val Gln 
1               5       


<210> 342
<211> 6
<212> PRT
<213> Homo sapiens

<400> 342
Leu Arg Ala Arg Ile Gln 
1               5       


<210> 343
<211> 6
<212> PRT
<213> Homo sapiens

<400> 343
Leu Arg Ala Arg Pro Gln 
1               5       


<210> 344
<211> 6
<212> PRT
<213> Homo sapiens

<400> 344
Leu Arg Cys Arg Lys Gln 
1               5       


<210> 345
<211> 6
<212> PRT
<213> Homo sapiens

<400> 345
Leu Arg Arg Arg Arg Gln 
1               5       


<210> 346
<211> 6
<212> PRT
<213> Homo sapiens

<400> 346
Leu Arg Arg Arg His Gln 
1               5       


<210> 347
<211> 6
<212> PRT
<213> Homo sapiens

<400> 347
Leu Arg Thr Arg Pro Gln 
1               5       


<210> 348
<211> 6
<212> PRT
<213> Homo sapiens

<400> 348
Leu Arg Tyr Arg Pro Gln 
1               5       


<210> 349
<211> 6
<212> PRT
<213> Homo sapiens

<400> 349
Leu Arg Asn Arg Pro Gln 
1               5       


