                               SEQUENCE LISTING

<110> CHAN ZUCKERBERG BIOHUB, INC.
      THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS

<130> 103182-1247836-003010WO

<140>
<141>

<150> 63/046,211
<151> 2020-06-30

<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 246
<212> DNA
<213> Human betaherpesvirus 5

<220>
<223> CMV enhancer nucleic acid sequence

<400> 1
ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt       60

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      120

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      180

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      240

accatg                                                                 246


<210> 2
<211> 278
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> CBA promoter element nucleic acid sequence

<400> 2
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg                              278


<210> 3
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Rabbit beta-globin splice acceptor nucleic acid sequence

<400> 3
ctctgctaac catgttcatg ccttcttctt tttcctacag                             40


<210> 4
<211> 315
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Spacer nucleic acid sequence

<400> 4
ggagtcgctg cgcgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg       60

ccccggctct gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct      120

ccgggctgta attagcgctt ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa      180

agccttgagg ggctccggga gggccctttg tgcgggggga gcggctcggg gctgtccgcg      240

gggggacggc tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac      300

cggcggctct agagc                                                       315


<210> 5
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> 5' spacer sequence

<400> 5
gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgccca        59


<210> 6
<211> 933
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> CAG promoter

<400> 6
ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt       60

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      120

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      180

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      240

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      300

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      360

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      420

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      480

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgcgc      540

tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg      600

accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg ctgtaattag      660

cgcttggttt aatgacggct tgtttctttt ctgtggctgc gtgaaagcct tgaggggctc      720

cgggagggcc ctttgtgcgg ggggagcggc tcggggctgt ccgcgggggg acggctgcct      780

tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg gctctagagc      840

ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca acgtgctggt      900

tattgtgctg tctcatcatt ttggcaaaga att                                   933


<210> 7
<211> 187
<212> PRT
<213> Homo sapiens 

<220>
<223> Human IFNbeta protein

<400> 7
Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210> 8
<211> 564
<212> DNA
<213> Homo sapiens 

<220>
<223> Human IFNbeta nucleic acid sequence

<400> 8
atgaccaaca agtgtctcct ccaaattgct ctcctgttgt gcttctccac tacagctctt       60

tccatgagct acaacttgct tggattccta caaagaagca gcaattttca gtgtcagaag      120

ctcctgtggc aattgaatgg gaggcttgaa tactgcctca aggacaggat gaactttgac      180

atccctgagg agattaagca gctgcagcag ttccagaagg aggacgccgc attgaccatc      240

tatgagatgc tccagaacat ctttgctatt ttcagacaag attcatctag cactggctgg      300

aatgagacta ttgttgagaa cctcctggct aatgtctatc atcagataaa ccatctgaag      360

acagtcctgg aagaaaaact ggagaaagaa gatttcacca ggggaaaact catgagcagt      420

ctgcacctga aaagatatta tgggaggatt ctgcattacc tgaaggccaa ggagtacagt      480

cactgtgcct ggaccatagt cagagtggaa atcctaagga acttttactt cattaacaga      540

cttacaggtt acctccgaaa ctaa                                             564


<210> 9
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Codon optimized human IFNbeta nucleic acid sequence

<400> 9
atgactaata agtgcctgct gcagatagcc ctgctcctgt gttttagcac cacggcactg       60

agtatgtcct ataatctgct gggctttctg cagaggtcat caaacttcca atgccaaaag      120

ttgctctggc agctgaacgg ccggctggag tattgtctga aagatcggat gaatttcgat      180

attcccgaag aaatcaaaca attgcaacaa tttcaaaagg aagatgcagc cctgacgatt      240

tacgaaatgc tgcaaaatat tttcgcaatc tttaggcagg acagcagctc cacaggttgg      300

aacgaaacca tagtggaaaa tctgctcgcg aacgtgtacc accaaatcaa tcacttgaaa      360

accgtgctcg aggagaagtt ggaaaaggaa gactttacac gtggcaagct tatgtcttcc      420

ttgcatctca agaggtacta cggccggata ctccactatc ttaaagctaa agaatattcc      480

cattgcgcgt ggacaatcgt gcgcgttgag attctgcgca atttctattt tatcaatcga      540

ctgacgggct atttgcggaa ttga                                             564


<210> 10
<211> 189
<212> PRT
<213> Homo sapiens 

<220>
<223> Human IFNalpha1 protein

<400> 10
Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210> 11
<211> 570
<212> DNA
<213> Homo sapiens 

<220>
<223> Human IFNalpha1 nucleic acid sequence

<400> 11
atggcctcgc cctttgcttt actgatggtc ctggtggtgc tcagctgcaa gtcaagctgc       60

tctctgggct gtgatctccc tgagacccac agcctggata acaggaggac cttgatgctc      120

ctggcacaaa tgagcagaat ctctccttcc tcctgtctga tggacagaca tgactttgga      180

tttccccagg aggagtttga tggcaaccag ttccagaagg ctccagccat ctctgtcctc      240

catgagctga tccagcagat cttcaacctc tttaccacaa aagattcatc tgctgcttgg      300

gatgaggacc tcctagacaa attctgcacc gaactctacc agcagctgaa tgacttggaa      360

gcctgtgtga tgcaggagga gagggtggga gaaactcccc tgatgaatgc ggactccatc      420

ttggctgtga agaaatactt ccgaagaatc actctctatc tgacagagaa gaaatacagc      480

ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccctctcttt atcaacaaac      540

ttgcaagaaa gattaaggag gaaggaataa                                       570


<210> 12
<211> 570
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Codon optimized human IFNalpha1 nucleic acid sequence

<400> 12
atggcttctc ctttcgccct tctcatggta ctcgttgttt tgtcctgtaa aagctcctgt       60

agccttggat gcgaccttcc ggaaacacat agtcttgaca atcgaagaac actgatgttg      120

cttgctcaga tgtcacgcat tagccccagc agttgcctta tggatcgcca cgatttcggg      180

ttcccgcaag aagaattcga cgggaatcaa tttcagaaag cgcctgctat ttcagtgctg      240

cacgaattga ttcaacaaat atttaatctg ttcacaacca aggacagttc cgccgcctgg      300

gacgaagatc ttctggataa gttttgtacg gagttgtatc aacaattgaa cgatctggaa      360

gcttgcgtca tgcaagaaga acgcgtaggc gagaccccac tcatgaacgc agattctatt      420

ctggcagtta agaagtattt taggcggata acgctgtact tgactgaaaa gaagtatagt      480

ccctgcgctt gggaagtggt gcgggccgag ataatgcggt ctcttagcct ctctaccaat      540

ctgcaggaga ggctgcgccg taaagagtag                                       570


<210> 13
<211> 166
<212> PRT
<213> Homo sapiens 

<220>
<223> Human IFNgamma protein

<400> 13
Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210> 14
<211> 501
<212> DNA
<213> Homo sapiens 

<220>
<223> Human IFNgamma nucleic acid sequence

<400> 14
atgaaatata caagttatat cttggctttt cagctctgca tcgttttggg ttctcttggc       60

tgttactgcc aggacccata tgtaaaagaa gcagaaaacc ttaagaaata ttttaatgca      120

ggtcattcag atgtagcgga taatggaact cttttcttag gcattttgaa gaattggaaa      180

gaggagagtg acagaaaaat aatgcagagc caaattgtct ccttttactt caaacttttt      240

aaaaacttta aagatgacca gagcatccaa aagagtgtgg agaccatcaa ggaagacatg      300

aatgtcaagt ttttcaatag caacaaaaag aaacgagatg acttcgaaaa gctgactaat      360

tattcggtaa ctgacttgaa tgtccaacgc aaagcaatac atgaactcat ccaagtgatg      420

gctgaactgt cgccagcagc taaaacaggg aagcgaaaaa ggagtcagat gctgtttcga      480

ggtcgaagag catcccagta a                                                501


<210> 15
<211> 501
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Codon optimized human IFNgamma nucleic acid sequence

<400> 15
atgaagtaca cctcttacat acttgccttc caactgtgta tagtcctggg aagcctgggg       60

tgctattgtc aagatcccta cgtcaaggaa gctgagaatc tgaagaagta cttcaacgcc      120

ggccactccg acgttgccga caacggcacg ctgtttctgg gtatcctgaa gaactggaag      180

gaagaatctg atcgaaagat catgcaatct cagatcgtgt ctttctattt caagctcttc      240

aagaacttca aggacgacca atcaattcag aaaagcgtgg aaacgataaa agaggatatg      300

aacgttaaat tctttaactc caacaagaag aagcgcgacg atttcgagaa attgacgaac      360

tacagcgtta ccgatctcaa cgtgcagaga aaggccatcc acgagctgat tcaggtaatg      420

gccgagctct cacctgcggc caagaccggc aaaagaaagc ggagccaaat gcttttcagg      480

ggcagacggg cttcacaatg a                                                501


<210> 16
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Spacer sequence

<400> 16
ctcctgggca acgtgctggt tattgtgctg tctcatcatt ttggcaaaga att              53


<210> 17
<211> 19
<212> PRT
<213> Teschovirus A

<220>
<223> P2A peptide

<400> 17
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 18
<211> 18
<212> PRT
<213> Thosea asigna virus

<220>
<223> T2A peptide

<400> 18
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 19
<211> 182
<212> PRT
<213> Mus sp. 

<220>
<223> Mouse IFNbeta protein

<400> 19
Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg 
            20                  25                  30          


Thr Asn Ile Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys 
        35                  40                  45              


Ile Asn Leu Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr 
    50                  55                  60                  


Glu Lys Met Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu 
65                  70                  75                  80  


Gln Asn Val Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp 
                85                  90                  95      


Asn Glu Thr Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr 
            100                 105                 110         


Val Phe Leu Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr 
        115                 120                 125             


Trp Glu Met Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg 
    130                 135                 140                 


Val Gln Arg Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met 
145                 150                 155                 160 


Val Val Arg Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu 
                165                 170                 175     


Thr Arg Asn Phe Gln Asn 
            180         


<210> 20
<211> 546
<212> DNA
<213> Mus sp. 

<220>
<223> Mouse IFNbeta nucleic acid sequence

<400> 20
aacaacaggt ggatcctcca cgctgcgttc ctgctgtgct tctccaccac agccctctcc       60

atcaactata agcagctcca gctccaagaa aggacgaaca ttcggaaatg tcaggagctc      120

ctggagcagc tgaatggaaa gatcaacctc acctacaggg cggacttcaa gatccctatg      180

gagatgacgg agaagatgca gaagagttac actgcctttg ccatccaaga gatgctccag      240

aatgtctttc ttgtcttcag aaacaatttc tccagcactg ggtggaatga gactattgtt      300

gtacgtctcc tggatgaact ccaccagcag acagtgtttc tgaagacagt actagaggaa      360

aagcaagagg aaagattgac gtgggagatg tcctcaactg ctctccactt gaagagctat      420

tactggaggg tgcaaaggta ccttaaactc atgaagtaca acagctacgc ctggatggtg      480

gtccgagcag agatcttcag gaactttctc atcattcgaa gacttaccag aaacttccaa      540

aactaa                                                                 546


<210> 21
<211> 186
<212> PRT
<213> Canis lupus familiaris

<220>
<223> Canine IFNbeta protein

<400> 21
Met Thr Ser Arg Cys Ile Leu Gln Thr Thr Leu Leu Leu Tyr Phe Ser 
1               5                   10                  15      


Thr Met Ala Leu Ala Met Ser Asn Asp Leu Leu Arg Ser Gln Leu Ser 
            20                  25                  30          


Ser Ser Ser Leu Glu Cys Gln Glu Leu Leu Leu Gln Leu Asn Gly Thr 
        35                  40                  45              


Thr Glu Tyr Cys Leu Lys Asp Arg Ile Asn Phe Glu Ile Pro Glu Glu 
    50                  55                  60                  


Ile Glu Lys Ser Arg Gln Phe Gln Lys Glu Asp Ile Ile Leu Ile Thr 
65                  70                  75                  80  


His Glu Met Phe Gln Lys Ile Phe Asp Ile Phe Arg Arg Asn Ile Ser 
                85                  90                  95      


Arg Thr Gly Trp Asn Glu Thr Thr Val Glu Asn Leu Leu Val Lys Leu 
            100                 105                 110         


His Trp Gln Lys Glu His Leu Glu Ile Ile Leu Glu Asp Val Lys Glu 
        115                 120                 125             


Lys Glu Asn Phe Thr Trp Asp Asn Arg Thr Leu Leu His Leu Lys Lys 
    130                 135                 140                 


Tyr Tyr Leu Arg Ile Val Gln Tyr Leu Lys Ala Lys Glu Tyr Ser Ile 
145                 150                 155                 160 


Cys Ala Trp Thr Ile Val Gln Ala Glu Ile Cys Arg Asn Phe Phe Phe 
                165                 170                 175     


Leu Asn Ile Leu Thr Asp Tyr Leu Gln Asn 
            180                 185     


<210> 22
<211> 558
<212> DNA
<213> Canis lupus familiaris

<220>
<223> Canine IFNbeta nucleic acid sequence

<400> 22
accagtagat gcatcctcca aacaactctc ctgttgtatt tctccaccat ggctcttgcc       60

atgagcaacg acttgcttcg atcccagcta agcagcagca gtttggagtg tcaggagctc      120

ctattacagt tgaatggaac cactgaatat tgcctcaagg acaggataaa cttcgagatc      180

cctgaggaaa tcgagaaatc acgccagttc cagaaggagg acatcatatt gatcacccat      240

gagatgttcc agaagatctt tgatattttc aggagaaata tctctagaac aggatggaat      300

gagaccactg tcgagaacct tcttgtgaag ctccactggc agaaggaaca tctggagata      360

atcctggagg acgtcaaaga gaaggaaaac ttcacctggg acaacaggac tcttctgcac      420

ctgaagaaat attacttaag gattgtgcag tacctgaagg ccaaggagta cagcatctgt      480

gcctggacaa tagtccaagc agaaatctgc aggaactttt tcttccttaa tatacttaca      540

gattatctcc agaactga                                                    558


<210> 23
<211> 589
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> WPRE nucleic acid sequence

<400> 23
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210> 24
<211> 122
<212> DNA
<213> Macaca mulatta polyomavirus 1

<220>
<223> SV40 poly(A) nucleic acid sequence

<400> 24
taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta       60

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      120

tt                                                                     122


<210> 25
<211> 2795
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNb

<400> 25
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc catgctctag      180

gaagagtacc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      240

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      300

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      360

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      420

tcatcgctat taccatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc      480

ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg      540

gggcgggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg      600

gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt      660

ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag      720

tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      780

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      840

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      900

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggctg tccgcggggg      960

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1020

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc     1080

aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattggatcc ggtaccgcca     1140

ccatgaccaa caagtgtctc ctccaaattg ctctcctgtt gtgcttctcc actacagctc     1200

tttccatgag ctacaacttg cttggattcc tacaaagaag cagcaatttt cagtgtcaga     1260

agctcctgtg gcaattgaat gggaggcttg aatactgcct caaggacagg atgaactttg     1320

acatccctga ggagattaag cagctgcagc agttccagaa ggaggacgcc gcattgacca     1380

tctatgagat gctccagaac atctttgcta ttttcagaca agattcatct agcactggct     1440

ggaatgagac tattgttgag aacctcctgg ctaatgtcta tcatcagata aaccatctga     1500

agacagtcct ggaagaaaaa ctggagaaag aagatttcac caggggaaaa ctcatgagca     1560

gtctgcacct gaaaagatat tatgggagga ttctgcatta cctgaaggcc aaggagtaca     1620

gtcactgtgc ctggaccata gtcagagtgg aaatcctaag gaacttttac ttcattaaca     1680

gacttacagg ttacctccga aactaagaat tcgatatcaa gcttatcgat aatcaacctc     1740

tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc     1800

tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca     1860

ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg     1920

tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca     1980

ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg     2040

cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg     2100

acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg     2160

ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg     2220

accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc     2280

ctcagacgag tcggatctcc ctttgggccg cctccccgca tcgataccgt cgacccgggc     2340

ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa     2400

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     2460

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     2520

agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtaaaatcg     2580

ataaggatct tcctagagca tggctacgta gataagtagc atggcgggtt aatcattaac     2640

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     2700

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     2760

gagcgagcgc gcagctgcat taatgaatcg gccaa                                2795


<210> 26
<211> 2780
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-mIFNb

<400> 26
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc catgctctag      180

gaagagtacc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      240

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      300

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      360

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      420

tcatcgctat taccatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc      480

ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg      540

gggcgggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg      600

gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt      660

ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag      720

tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      780

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      840

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      900

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggctg tccgcggggg      960

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1020

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc     1080

aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattggatcc ggtaccgcca     1140

ccatgaacaa caggtggatc ctccacgctg cgttcctgct gtgcttctcc accacagccc     1200

tctccatcaa ctataagcag ctccagctcc aagaaaggac gaacattcgg aaatgtcagg     1260

agctcctgga gcagctgaat ggaaagatca acctcaccta cagggcggac ttcaagatcc     1320

ctatggagat gacggagaag atgcagaaga gttacactgc ctttgccatc caagagatgc     1380

tccagaatgt ctttcttgtc ttcagaaaca atttctccag cactgggtgg aatgagacta     1440

ttgttgtacg tctcctggat gaactccacc agcagacagt gtttctgaag acagtactag     1500

aggaaaagca agaggaaaga ttgacgtggg agatgtcctc aactgctctc cacttgaaga     1560

gctattactg gagggtgcaa aggtacctta aactcatgaa gtacaacagc tacgcctgga     1620

tggtggtccg agcagagatc ttcaggaact ttctcatcat tcgaagactt accagaaact     1680

tccaaaacta agaattcgat atcaagctta tcgataatca acctctggat tacaaaattt     1740

gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg     1800

ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt     1860

ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg     1920

tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc     1980

agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg     2040

cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt     2100

tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc     2160

gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg     2220

gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga     2280

tctccctttg ggccgcctcc ccgcatcgat accgtcgacc cgggcggccg cttcgagcag     2340

acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat     2400

gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata     2460

aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg gagatgtggg     2520

aggtttttta aagcaagtaa aacctctaca aatgtggtaa aatcgataag gatcttccta     2580

gagcatggct acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta     2640

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     2700

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc     2760

tgcattaatg aatcggccaa                                                 2780


<210> 27
<211> 2792
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-cIFNb

<400> 27
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc catgctctag      180

gaagagtacc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      240

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      300

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      360

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      420

tcatcgctat taccatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc      480

ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg      540

gggcgggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg      600

gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt      660

ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag      720

tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      780

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      840

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      900

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggctg tccgcggggg      960

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1020

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc     1080

aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattggatcc ggtaccgcca     1140

ccatgaccag tagatgcatc ctccaaacaa ctctcctgtt gtatttctcc accatggctc     1200

ttgccatgag caacgacttg cttcgatccc agctaagcag cagcagtttg gagtgtcagg     1260

agctcctatt acagttgaat ggaaccactg aatattgcct caaggacagg ataaacttcg     1320

agatccctga ggaaatcgag aaatcacgcc agttccagaa ggaggacatc atattgatca     1380

cccatgagat gttccagaag atctttgata ttttcaggag aaatatctct agaacaggat     1440

ggaatgagac cactgtcgag aaccttcttg tgaagctcca ctggcagaag gaacatctgg     1500

agataatcct ggaggacgtc aaagagaagg aaaacttcac ctgggacaac aggactcttc     1560

tgcacctgaa gaaatattac ttaaggattg tgcagtacct gaaggccaag gagtacagca     1620

tctgtgcctg gacaatagtc caagcagaaa tctgcaggaa ctttttcttc cttaatatac     1680

ttacagatta tctccagaac tgagaattcg atatcaagct tatcgataat caacctctgg     1740

attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct tttacgctat     1800

gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg gctttcattt     1860

tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg cccgttgtca     1920

ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt tggggcattg     1980

ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt gccacggcgg     2040

aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca     2100

attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca     2160

cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat ccagcggacc     2220

ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc     2280

agacgagtcg gatctccctt tgggccgcct ccccgcatcg ataccgtcga cccgggcggc     2340

cgcttcgagc agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc     2400

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     2460

taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg     2520

gggagatgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt aaaatcgata     2580

aggatcttcc tagagcatgg ctacgtagat aagtagcatg gcgggttaat cattaactac     2640

aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     2700

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     2760

cgagcgcgca gctgcattaa tgaatcggcc aa                                   2792


<210> 28
<211> 2806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNa1

<400> 28
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg gcctcgccct ttgctttact gatggtcctg gtggtgctca gctgcaagtc     1200

aagctgctct ctgggctgtg atctccctga gacccacagc ctggataaca ggaggacctt     1260

gatgctcctg gcacaaatga gcagaatctc tccttcctcc tgtctgatgg acagacatga     1320

ctttggattt ccccaggagg agtttgatgg caaccagttc cagaaggctc cagccatctc     1380

tgtcctccat gagctgatcc agcagatctt caacctcttt accacaaaag attcatctgc     1440

tgcttgggat gaggacctcc tagacaaatt ctgcaccgaa ctctaccagc agctgaatga     1500

cttggaagcc tgtgtgatgc aggaggagag ggtgggagaa actcccctga tgaatgcgga     1560

ctccatcttg gctgtgaaga aatacttccg aagaatcact ctctatctga cagagaagaa     1620

atacagccct tgtgcctggg aggttgtcag agcagaaatc atgagatccc tctctttatc     1680

aacaaacttg caagaaagat taaggaggaa ggaataagaa ttcgatatca agcttatcga     1740

taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc     1800

tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg     1860

tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt     1920

gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac     1980

tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc     2040

tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct     2100

gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc cttggctgct     2160

cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct     2220

caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct     2280

tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc atcgataccg     2340

tcgacccggg cggccgcttc gagcagacat gataagatac attgatgagt ttggacaaac     2400

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     2460

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     2520

gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     2580

tggtaaaatc gataaggatc ttcctagagc atggctacgt agataagtag catggcgggt     2640

taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     2700

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     2760

cctcagtgag cgagcgagcg cgcagctgca ttaatgaatc ggccaa                    2806


<210> 29
<211> 2737
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNg

<400> 29
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg aaatatacaa gttatatctt ggcttttcag ctctgcatcg ttttgggttc     1200

tcttggctgt tactgccagg acccatatgt aaaagaagca gaaaacctta agaaatattt     1260

taatgcaggt cattcagatg tagcggataa tggaactctt ttcttaggca ttttgaagaa     1320

ttggaaagag gagagtgaca gaaaaataat gcagagccaa attgtctcct tttacttcaa     1380

actttttaaa aactttaaag atgaccagag catccaaaag agtgtggaga ccatcaagga     1440

agacatgaat gtcaagtttt tcaatagcaa caaaaagaaa cgagatgact tcgaaaagct     1500

gactaattat tcggtaactg acttgaatgt ccaacgcaaa gcaatacatg aactcatcca     1560

agtgatggct gaactgtcgc cagcagctaa aacagggaag cgaaaaagga gtcagatgct     1620

gtttcgaggt cgaagagcat cccagtaaga attcgatatc aagcttatcg ataatcaacc     1680

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     1740

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     1800

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     1860

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     1920

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     1980

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     2040

tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt     2100

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     2160

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     2220

ccctcagacg agtcggatct ccctttgggc cgcctccccg catcgatacc gtcgacccgg     2280

gcggccgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag     2340

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     2400

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     2460

tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat     2520

cgataaggat cttcctagag catggctacg tagataagta gcatggcggg ttaatcatta     2580

actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     2640

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     2700

gcgagcgagc gcgcagctgc attaatgaat cggccaa                              2737


<210> 30
<211> 3343
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNb-P2A-hIFNa1

<400> 30
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg accaacaagt gtctcctcca aattgctctc ctgttgtgct tctccactac     1200

agctctttcc atgagctaca acttgcttgg attcctacaa agaagcagca attttcagtg     1260

tcagaagctc ctgtggcaat tgaatgggag gcttgaatac tgcctcaagg acaggatgaa     1320

ctttgacatc cctgaggaga ttaagcagct gcagcagttc cagaaggagg acgccgcatt     1380

gaccatctat gagatgctcc agaacatctt tgctattttc agacaagatt catctagcac     1440

tggctggaat gagactattg ttgagaacct cctggctaat gtctatcatc agataaacca     1500

tctgaagaca gtcctggaag aaaaactgga gaaagaagat ttcaccaggg gaaaactcat     1560

gagcagtctg cacctgaaaa gatattatgg gaggattctg cattacctga aggccaagga     1620

gtacagtcac tgtgcctgga ccatagtcag agtggaaatc ctaaggaact tttacttcat     1680

taacagactt acaggttacc tccgaaacta aggaagcggc gccaccaatt tcagcctgct     1740

gaaacaggcc ggcgacgtgg aagagaaccc tggccctcac agcctggata acaggaggac     1800

cttgatgctc ctggcacaaa tgagcagaat ctctccttcc tcctgtctga tggacagaca     1860

tgactttgga tttccccagg aggagtttga tggcaaccag ttccagaagg ctccagccat     1920

ctctgtcctc catgagctga tccagcagat cttcaacctc tttaccacaa aagattcatc     1980

tgctgcttgg gatgaggacc tcctagacaa attctgcacc gaactctacc agcagctgaa     2040

tgacttggaa gcctgtgtga tgcaggagga gagggtggga gaaactcccc tgatgaatgc     2100

ggactccatc ttggctgtga agaaatactt ccgaagaatc actctctatc tgacagagaa     2160

gaaatacagc ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccctctcttt     2220

atcaacaaac ttgcaagaaa gattaaggag gaaggaataa gatatcaagc ttatcgataa     2280

tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc     2340

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat     2400

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg     2460

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg     2520

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat     2580

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt     2640

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc     2700

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa     2760

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg     2820

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcatc gataccgtcg     2880

acccgggcgg ccgcttcgag cagacatgat aagatacatt gatgagtttg gacaaaccac     2940

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     3000

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt     3060

tcaggttcag ggggagatgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg     3120

taaaatcgat aaggatcttc ctagagcatg gctacgtaga taagtagcat ggcgggttaa     3180

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3240

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3300

cagtgagcga gcgagcgcgc agctgcatta atgaatcggc caa                       3343


<210> 31
<211> 3361
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNb-P2A-hIFNg

<400> 31
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg accaacaagt gtctcctcca aattgctctc ctgttgtgct tctccactac     1200

agctctttcc atgagctaca acttgcttgg attcctacaa agaagcagca attttcagtg     1260

tcagaagctc ctgtggcaat tgaatgggag gcttgaatac tgcctcaagg acaggatgaa     1320

ctttgacatc cctgaggaga ttaagcagct gcagcagttc cagaaggagg acgccgcatt     1380

gaccatctat gagatgctcc agaacatctt tgctattttc agacaagatt catctagcac     1440

tggctggaat gagactattg ttgagaacct cctggctaat gtctatcatc agataaacca     1500

tctgaagaca gtcctggaag aaaaactgga gaaagaagat ttcaccaggg gaaaactcat     1560

gagcagtctg cacctgaaaa gatattatgg gaggattctg cattacctga aggccaagga     1620

gtacagtcac tgtgcctgga ccatagtcag agtggaaatc ctaaggaact tttacttcat     1680

taacagactt acaggttacc tccgaaacta aggaagcggc gccaccaatt tcagcctgct     1740

gaaacaggcc ggcgacgtgg aagagaaccc tggccctatg aaatatacaa gttatatctt     1800

ggcttttcag ctctgcatcg ttttgggttc tcttggctgt tactgccagg acccatatgt     1860

aaaagaagca gaaaacctta agaaatattt taatgcaggt cattcagatg tagcggataa     1920

tggaactctt ttcttaggca ttttgaagaa ttggaaagag gagagtgaca gaaaaataat     1980

gcagagccaa attgtctcct tttacttcaa actttttaaa aactttaaag atgaccagag     2040

catccaaaag agtgtggaga ccatcaagga agacatgaat gtcaagtttt tcaatagcaa     2100

caaaaagaaa cgagatgact tcgaaaagct gactaattat tcggtaactg acttgaatgt     2160

ccaacgcaaa gcaatacatg aactcatcca agtgatggct gaactgtcgc cagcagctaa     2220

aacagggaag cgaaaaagga gtcagatgct gtttcgaggt cgaagagcat cccagtaaga     2280

tatcaagctt atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat     2340

tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca     2400

tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc     2460

tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc     2520

tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt     2580

cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     2640

gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc     2700

ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta     2760

cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg     2820

gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc     2880

cccgcatcga taccgtcgac ccgggcggcc gcttcgagca gacatgataa gatacattga     2940

tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg     3000

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa     3060

ttgcattcat tttatgtttc aggttcaggg ggagatgtgg gaggtttttt aaagcaagta     3120

aaacctctac aaatgtggta aaatcgataa ggatcttcct agagcatggc tacgtagata     3180

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     3240

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3300

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcattaat gaatcggcca     3360

a                                                                     3361


<210> 32
<211> 3907
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNb-P2A-hIFNa1-T2A-hIFNg

<400> 32
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg accaacaagt gtctcctcca aattgctctc ctgttgtgct tctccactac     1200

agctctttcc atgagctaca acttgcttgg attcctacaa agaagcagca attttcagtg     1260

tcagaagctc ctgtggcaat tgaatgggag gcttgaatac tgcctcaagg acaggatgaa     1320

ctttgacatc cctgaggaga ttaagcagct gcagcagttc cagaaggagg acgccgcatt     1380

gaccatctat gagatgctcc agaacatctt tgctattttc agacaagatt catctagcac     1440

tggctggaat gagactattg ttgagaacct cctggctaat gtctatcatc agataaacca     1500

tctgaagaca gtcctggaag aaaaactgga gaaagaagat ttcaccaggg gaaaactcat     1560

gagcagtctg cacctgaaaa gatattatgg gaggattctg cattacctga aggccaagga     1620

gtacagtcac tgtgcctgga ccatagtcag agtggaaatc ctaaggaact tttacttcat     1680

taacagactt acaggttacc tccgaaacta aggaagcggc gccaccaatt tcagcctgct     1740

gaaacaggcc ggcgacgtgg aagagaaccc tggccctcac agcctggata acaggaggac     1800

cttgatgctc ctggcacaaa tgagcagaat ctctccttcc tcctgtctga tggacagaca     1860

tgactttgga tttccccagg aggagtttga tggcaaccag ttccagaagg ctccagccat     1920

ctctgtcctc catgagctga tccagcagat cttcaacctc tttaccacaa aagattcatc     1980

tgctgcttgg gatgaggacc tcctagacaa attctgcacc gaactctacc agcagctgaa     2040

tgacttggaa gcctgtgtga tgcaggagga gagggtggga gaaactcccc tgatgaatgc     2100

ggactccatc ttggctgtga agaaatactt ccgaagaatc actctctatc tgacagagaa     2160

gaaatacagc ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccctctcttt     2220

atcaacaaac ttgcaagaaa gattaaggag gaaggaataa ggaagcggcg agggcagggg     2280

aagtctacta acatgcgggg acgtggagga aaatcccggc ccaatgaaat atacaagtta     2340

tatcttggct tttcagctct gcatcgtttt gggttctctt ggctgttact gccaggaccc     2400

atatgtaaaa gaagcagaaa accttaagaa atattttaat gcaggtcatt cagatgtagc     2460

ggataatgga actcttttct taggcatttt gaagaattgg aaagaggaga gtgacagaaa     2520

aataatgcag agccaaattg tctcctttta cttcaaactt tttaaaaact ttaaagatga     2580

ccagagcatc caaaagagtg tggagaccat caaggaagac atgaatgtca agtttttcaa     2640

tagcaacaaa aagaaacgag atgacttcga aaagctgact aattattcgg taactgactt     2700

gaatgtccaa cgcaaagcaa tacatgaact catccaagtg atggctgaac tgtcgccagc     2760

agctaaaaca gggaagcgaa aaaggagtca gatgctgttt cgaggtcgaa gagcatccca     2820

gtaagatatc aagcttatcg ataatcaacc tctggattac aaaatttgtg aaagattgac     2880

tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt     2940

gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt     3000

gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt     3060

gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg     3120

gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg     3180

ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc     3240

atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt     3300

ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc     3360

tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc     3420

cgcctccccg catcgatacc gtcgacccgg gcggccgctt cgagcagaca tgataagata     3480

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga     3540

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa     3600

caacaattgc attcatttta tgtttcaggt tcagggggag atgtgggagg ttttttaaag     3660

caagtaaaac ctctacaaat gtggtaaaat cgataaggat cttcctagag catggctacg     3720

tagataagta gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg     3780

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     3840

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc attaatgaat     3900

cggccaa                                                               3907


<210> 33
<211> 2800
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNb-Codon Optimized

<400> 33
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg actaataagt gcctgctgca gatagccctg ctcctgtgtt ttagcaccac     1200

ggcactgagt atgtcctata atctgctggg ctttctgcag aggtcatcaa acttccaatg     1260

ccaaaagttg ctctggcagc tgaacggccg gctggagtat tgtctgaaag atcggatgaa     1320

tttcgatatt cccgaagaaa tcaaacaatt gcaacaattt caaaaggaag atgcagccct     1380

gacgatttac gaaatgctgc aaaatatttt cgcaatcttt aggcaggaca gcagctccac     1440

aggttggaac gaaaccatag tggaaaatct gctcgcgaac gtgtaccacc aaatcaatca     1500

cttgaaaacc gtgctcgagg agaagttgga aaaggaagac tttacacgtg gcaagcttat     1560

gtcttccttg catctcaaga ggtactacgg ccggatactc cactatctta aagctaaaga     1620

atattcccat tgcgcgtgga caatcgtgcg cgttgagatt ctgcgcaatt tctattttat     1680

caatcgactg acgggctatt tgcggaattg agaattcgat atcaagctta tcgataatca     1740

acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt     1800

tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc     1860

tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc     1920

cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg     1980

gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc     2040

cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg     2100

cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg     2160

tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc     2220

agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct     2280

tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcatcgat accgtcgacc     2340

cgggcggccg cttcgagcag acatgataag atacattgat gagtttggac aaaccacaac     2400

tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt     2460

aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca     2520

ggttcagggg gagatgtggg aggtttttta aagcaagtaa aacctctaca aatgtggtaa     2580

aatcgataag gatcttccta gagcatggct acgtagataa gtagcatggc gggttaatca     2640

ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     2700

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     2760

tgagcgagcg agcgcgcagc tgcattaatg aatcggccaa                           2800


<210> 34
<211> 2806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNa1-Codon Optimized

<400> 34
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg gcttctcctt tcgcccttct catggtactc gttgttttgt cctgtaaaag     1200

ctcctgtagc cttggatgcg accttccgga aacacatagt cttgacaatc gaagaacact     1260

gatgttgctt gctcagatgt cacgcattag ccccagcagt tgccttatgg atcgccacga     1320

tttcgggttc ccgcaagaag aattcgacgg gaatcaattt cagaaagcgc ctgctatttc     1380

agtgctgcac gaattgattc aacaaatatt taatctgttc acaaccaagg acagttccgc     1440

cgcctgggac gaagatcttc tggataagtt ttgtacggag ttgtatcaac aattgaacga     1500

tctggaagct tgcgtcatgc aagaagaacg cgtaggcgag accccactca tgaacgcaga     1560

ttctattctg gcagttaaga agtattttag gcggataacg ctgtacttga ctgaaaagaa     1620

gtatagtccc tgcgcttggg aagtggtgcg ggccgagata atgcggtctc ttagcctctc     1680

taccaatctg caggagaggc tgcgccgtaa agagtaggaa ttcgatatca agcttatcga     1740

taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc     1800

tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg     1860

tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt     1920

gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac     1980

tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc     2040

tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct     2100

gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc cttggctgct     2160

cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct     2220

caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct     2280

tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc atcgataccg     2340

tcgacccggg cggccgcttc gagcagacat gataagatac attgatgagt ttggacaaac     2400

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     2460

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     2520

gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     2580

tggtaaaatc gataaggatc ttcctagagc atggctacgt agataagtag catggcgggt     2640

taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     2700

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     2760

cctcagtgag cgagcgagcg cgcagctgca ttaatgaatc ggccaa                    2806


<210> 35
<211> 2737
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNg Codon Optimized

<400> 35
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg aagtacacct cttacatact tgccttccaa ctgtgtatag tcctgggaag     1200

cctggggtgc tattgtcaag atccctacgt caaggaagct gagaatctga agaagtactt     1260

caacgccggc cactccgacg ttgccgacaa cggcacgctg tttctgggta tcctgaagaa     1320

ctggaaggaa gaatctgatc gaaagatcat gcaatctcag atcgtgtctt tctatttcaa     1380

gctcttcaag aacttcaagg acgaccaatc aattcagaaa agcgtggaaa cgataaaaga     1440

ggatatgaac gttaaattct ttaactccaa caagaagaag cgcgacgatt tcgagaaatt     1500

gacgaactac agcgttaccg atctcaacgt gcagagaaag gccatccacg agctgattca     1560

ggtaatggcc gagctctcac ctgcggccaa gaccggcaaa agaaagcgga gccaaatgct     1620

tttcaggggc agacgggctt cacaatgaga attcgatatc aagcttatcg ataatcaacc     1680

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     1740

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     1800

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     1860

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     1920

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     1980

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     2040

tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt     2100

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     2160

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     2220

ccctcagacg agtcggatct ccctttgggc cgcctccccg catcgatacc gtcgacccgg     2280

gcggccgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag     2340

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     2400

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     2460

tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat     2520

cgataaggat cttcctagag catggctacg tagataagta gcatggcggg ttaatcatta     2580

actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     2640

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     2700

gcgagcgagc gcgcagctgc attaatgaat cggccaa                              2737


<210> 36
<211> 3430
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNb-P2A-hIFNa1 Codon Optimized

<400> 36
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg actaataagt gcctgctgca gatagccctg ctcctgtgtt ttagcaccac     1200

ggcactgagt atgtcctata atctgctggg ctttctgcag aggtcatcaa acttccaatg     1260

ccaaaagttg ctctggcagc tgaacggccg gctggagtat tgtctgaaag atcggatgaa     1320

tttcgatatt cccgaagaaa tcaaacaatt gcaacaattt caaaaggaag atgcagccct     1380

gacgatttac gaaatgctgc aaaatatttt cgcaatcttt aggcaggaca gcagctccac     1440

aggttggaac gaaaccatag tggaaaatct gctcgcgaac gtgtaccacc aaatcaatca     1500

cttgaaaacc gtgctcgagg agaagttgga aaaggaagac tttacacgtg gcaagcttat     1560

gtcttccttg catctcaaga ggtactacgg ccggatactc cactatctta aagctaaaga     1620

atattcccat tgcgcgtgga caatcgtgcg cgttgagatt ctgcgcaatt tctattttat     1680

caatcgactg acgggctatt tgcggaattg aggaagcggc gccaccaatt tcagcctgct     1740

gaaacaggcc ggcgacgtgg aagagaaccc tggccctatg gcttctcctt tcgcccttct     1800

catggtactc gttgttttgt cctgtaaaag ctcctgtagc cttggatgcg accttccgga     1860

aacacatagt cttgacaatc gaagaacact gatgttgctt gctcagatgt cacgcattag     1920

ccccagcagt tgccttatgg atcgccacga tttcgggttc ccgcaagaag aattcgacgg     1980

gaatcaattt cagaaagcgc ctgctatttc agtgctgcac gaattgattc aacaaatatt     2040

taatctgttc acaaccaagg acagttccgc cgcctgggac gaagatcttc tggataagtt     2100

ttgtacggag ttgtatcaac aattgaacga tctggaagct tgcgtcatgc aagaagaacg     2160

cgtaggcgag accccactca tgaacgcaga ttctattctg gcagttaaga agtattttag     2220

gcggataacg ctgtacttga ctgaaaagaa gtatagtccc tgcgcttggg aagtggtgcg     2280

ggccgagata atgcggtctc ttagcctctc taccaatctg caggagaggc tgcgccgtaa     2340

agagtaggat atcaagctta tcgataatca acctctggat tacaaaattt gtgaaagatt     2400

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     2460

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     2520

gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac     2580

tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc     2640

cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc     2700

ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa     2760

atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc     2820

cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc     2880

ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg     2940

ggccgcctcc ccgcatcgat accgtcgacc cgggcggccg cttcgagcag acatgataag     3000

atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg     3060

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa     3120

caacaacaat tgcattcatt ttatgtttca ggttcagggg gagatgtggg aggtttttta     3180

aagcaagtaa aacctctaca aatgtggtaa aatcgataag gatcttccta gagcatggct     3240

acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt     3300

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3360

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tgcattaatg     3420

aatcggccaa                                                            3430


<210> 37
<211> 3361
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIFNb-P2A-hIFNg Codon Optimized

<400> 37
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg actaataagt gcctgctgca gatagccctg ctcctgtgtt ttagcaccac     1200

ggcactgagt atgtcctata atctgctggg ctttctgcag aggtcatcaa acttccaatg     1260

ccaaaagttg ctctggcagc tgaacggccg gctggagtat tgtctgaaag atcggatgaa     1320

tttcgatatt cccgaagaaa tcaaacaatt gcaacaattt caaaaggaag atgcagccct     1380

gacgatttac gaaatgctgc aaaatatttt cgcaatcttt aggcaggaca gcagctccac     1440

aggttggaac gaaaccatag tggaaaatct gctcgcgaac gtgtaccacc aaatcaatca     1500

cttgaaaacc gtgctcgagg agaagttgga aaaggaagac tttacacgtg gcaagcttat     1560

gtcttccttg catctcaaga ggtactacgg ccggatactc cactatctta aagctaaaga     1620

atattcccat tgcgcgtgga caatcgtgcg cgttgagatt ctgcgcaatt tctattttat     1680

caatcgactg acgggctatt tgcggaattg aggaagcggc gccaccaatt tcagcctgct     1740

gaaacaggcc ggcgacgtgg aagagaaccc tggccctatg aagtacacct cttacatact     1800

tgccttccaa ctgtgtatag tcctgggaag cctggggtgc tattgtcaag atccctacgt     1860

caaggaagct gagaatctga agaagtactt caacgccggc cactccgacg ttgccgacaa     1920

cggcacgctg tttctgggta tcctgaagaa ctggaaggaa gaatctgatc gaaagatcat     1980

gcaatctcag atcgtgtctt tctatttcaa gctcttcaag aacttcaagg acgaccaatc     2040

aattcagaaa agcgtggaaa cgataaaaga ggatatgaac gttaaattct ttaactccaa     2100

caagaagaag cgcgacgatt tcgagaaatt gacgaactac agcgttaccg atctcaacgt     2160

gcagagaaag gccatccacg agctgattca ggtaatggcc gagctctcac ctgcggccaa     2220

gaccggcaaa agaaagcgga gccaaatgct tttcaggggc agacgggctt cacaatgaga     2280

tatcaagctt atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat     2340

tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca     2400

tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc     2460

tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc     2520

tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt     2580

cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     2640

gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc     2700

ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta     2760

cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg     2820

gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc     2880

cccgcatcga taccgtcgac ccgggcggcc gcttcgagca gacatgataa gatacattga     2940

tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg     3000

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa     3060

ttgcattcat tttatgtttc aggttcaggg ggagatgtgg gaggtttttt aaagcaagta     3120

aaacctctac aaatgtggta aaatcgataa ggatcttcct agagcatggc tacgtagata     3180

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     3240

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3300

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcattaat gaatcggcca     3360

a                                                                     3361


<210> 38
<211> 3994
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AAV-CAG-hIfNb-P2A-hIFNa1-T2A-hIFNg codon optimized

<400> 38
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg actaataagt gcctgctgca gatagccctg ctcctgtgtt ttagcaccac     1200

ggcactgagt atgtcctata atctgctggg ctttctgcag aggtcatcaa acttccaatg     1260

ccaaaagttg ctctggcagc tgaacggccg gctggagtat tgtctgaaag atcggatgaa     1320

tttcgatatt cccgaagaaa tcaaacaatt gcaacaattt caaaaggaag atgcagccct     1380

gacgatttac gaaatgctgc aaaatatttt cgcaatcttt aggcaggaca gcagctccac     1440

aggttggaac gaaaccatag tggaaaatct gctcgcgaac gtgtaccacc aaatcaatca     1500

cttgaaaacc gtgctcgagg agaagttgga aaaggaagac tttacacgtg gcaagcttat     1560

gtcttccttg catctcaaga ggtactacgg ccggatactc cactatctta aagctaaaga     1620

atattcccat tgcgcgtgga caatcgtgcg cgttgagatt ctgcgcaatt tctattttat     1680

caatcgactg acgggctatt tgcggaattg aggaagcggc gccaccaatt tcagcctgct     1740

gaaacaggcc ggcgacgtgg aagagaaccc tggccctatg gcttctcctt tcgcccttct     1800

catggtactc gttgttttgt cctgtaaaag ctcctgtagc cttggatgcg accttccgga     1860

aacacatagt cttgacaatc gaagaacact gatgttgctt gctcagatgt cacgcattag     1920

ccccagcagt tgccttatgg atcgccacga tttcgggttc ccgcaagaag aattcgacgg     1980

gaatcaattt cagaaagcgc ctgctatttc agtgctgcac gaattgattc aacaaatatt     2040

taatctgttc acaaccaagg acagttccgc cgcctgggac gaagatcttc tggataagtt     2100

ttgtacggag ttgtatcaac aattgaacga tctggaagct tgcgtcatgc aagaagaacg     2160

cgtaggcgag accccactca tgaacgcaga ttctattctg gcagttaaga agtattttag     2220

gcggataacg ctgtacttga ctgaaaagaa gtatagtccc tgcgcttggg aagtggtgcg     2280

ggccgagata atgcggtctc ttagcctctc taccaatctg caggagaggc tgcgccgtaa     2340

agagtaggga agcggcgagg gcaggggaag tctactaaca tgcggggacg tggaggaaaa     2400

tcccggccca atgaagtaca cctcttacat acttgccttc caactgtgta tagtcctggg     2460

aagcctgggg tgctattgtc aagatcccta cgtcaaggaa gctgagaatc tgaagaagta     2520

cttcaacgcc ggccactccg acgttgccga caacggcacg ctgtttctgg gtatcctgaa     2580

gaactggaag gaagaatctg atcgaaagat catgcaatct cagatcgtgt ctttctattt     2640

caagctcttc aagaacttca aggacgacca atcaattcag aaaagcgtgg aaacgataaa     2700

agaggatatg aacgttaaat tctttaactc caacaagaag aagcgcgacg atttcgagaa     2760

attgacgaac tacagcgtta ccgatctcaa cgtgcagaga aaggccatcc acgagctgat     2820

tcaggtaatg gccgagctct cacctgcggc caagaccggc aaaagaaagc ggagccaaat     2880

gcttttcagg ggcagacggg cttcacaatg agatatcaag cttatcgata atcaacctct     2940

ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct     3000

atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat     3060

tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt     3120

caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat     3180

tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc     3240

ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga     3300

caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg cctgtgttgc     3360

cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga     3420

ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc     3480

tcagacgagt cggatctccc tttgggccgc ctccccgcat cgataccgtc gacccgggcg     3540

gccgcttcga gcagacatga taagatacat tgatgagttt ggacaaacca caactagaat     3600

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     3660

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     3720

gggggagatg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtaaaatcga     3780

taaggatctt cctagagcat ggctacgtag ataagtagca tggcgggtta atcattaact     3840

acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     3900

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     3960

agcgagcgcg cagctgcatt aatgaatcgg ccaa                                 3994


