                         SEQUENCE LISTING

<110>  Ko, Young Hee
 
<120>  Cellular Energy Inhibitor Formulations for the Treatment of Pathogenic Infections and Associated Methods

<130>  2553-026.PCT

<140>  PCT/US 21/39722
<141>  2010-06-29

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
        35                  40                  45              


Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
65                  70                  75                  80  


Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                85                  90                  95      


Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
            100                 105                 110         


Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
        115                 120                 125             


His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
145                 150                 155                 160 


Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                165                 170                 175     


Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
            180                 185                 190         


Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
    210                 215                 220                 


Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
305                 310                 315                 320 


Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                325                 330                 335     


Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
            340                 345                 350         


Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
        355                 360                 365             


Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
385                 390                 395                 400 


Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                405                 410                 415     


Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
            420                 425                 430         


Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
465                 470                 475                 480 


Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                485                 490                 495     


Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
            500                 505                 510         


Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
            580                 585                 590         


Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
625                 630                 635                 640 


Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
    690                 695                 700                 


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala 
                725                 730                 735     


Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
        755                 760                 765             


Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
865                 870                 875                 880 


Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
            900                 905                 910         


Thr Glu Ala Ser Ser 
        915         


<210>  2
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Cys Glu His Ser Leu Ser Leu Pro Cys Arg Gly Ala Glu Ala 
1               5                   10                  15      


Trp Glu Ile Gly Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser Asp 
            20                  25                  30          


Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys Asn 
        35                  40                  45              


Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu Pro 
    50                  55                  60                  


Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe Ile 
65                  70                  75                  80  


Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln Val 
                85                  90                  95      


Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr Asp 
            100                 105                 110         


Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp His 
        115                 120                 125             


Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys Asp 
    130                 135                 140                 


Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln Ser 
145                 150                 155                 160 


Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys Ala 
                165                 170                 175     


Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala Ile 
            180                 185                 190         


Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn Asp 
        195                 200                 205             


Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys Glu 
    210                 215                 220                 


Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu 
225                 230                 235                 240 


Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys Ile 
                245                 250                 255     


Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp Ile 
            260                 265                 270         


Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro Gly 
        275                 280                 285             


Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu Leu 
    290                 295                 300                 


Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe Glu 
305                 310                 315                 320 


Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr Ser 
                325                 330                 335     


Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala Lys 
            340                 345                 350         


Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys Val 
        355                 360                 365             


Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn Leu 
    370                 375                 380                 


Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn Lys 
385                 390                 395                 400 


Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu Tyr 
                405                 410                 415     


Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg Arg 
            420                 425                 430         


Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala Glu 
    450                 455                 460                 


Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr Lys 
465                 470                 475                 480 


Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu Leu 
                485                 490                 495     


Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu Pro 
            500                 505                 510         


Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe Leu 
        515                 520                 525             


Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys Ile 
    530                 535                 540                 


Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr Ala 
545                 550                 555                 560 


Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His 
                565                 570                 575     


Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys Gly 
            580                 585                 590         


Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln Thr 
        595                 600                 605             


Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys Ala 
    610                 615                 620                 


Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala Ile 
625                 630                 635                 640 


Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn Asp 
                645                 650                 655     


Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys Glu 
            660                 665                 670         


Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu Glu 
        675                 680                 685             


Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys Ile 
    690                 695                 700                 


Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp Ile 
705                 710                 715                 720 


Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala Gly 
                725                 730                 735     


Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu Ile 
            740                 745                 750         


Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe Arg 
        755                 760                 765             


Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr Lys 
    770                 775                 780                 


Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg 
785                 790                 795                 800 


Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser Ile 
                805                 810                 815     


Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln Leu 
            820                 825                 830         


Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn Arg 
        835                 840                 845             


Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu Tyr 
    850                 855                 860                 


Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys Glu 
865                 870                 875                 880 


Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly Ser 
                885                 890                 895     


Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg Thr 
            900                 905                 910         


Glu Ala Ser Ser 
        915     


<210>  3
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Gln Ile Cys Gln Arg Glu Ser Ala Thr Ala Ala Glu Lys Pro 
1               5                   10                  15      


Lys Leu His Leu Leu Ala Glu Ser Glu Ile Asp Lys Tyr Leu Tyr Ala 
            20                  25                  30          


Met Arg Leu Ser Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg 
        35                  40                  45              


Lys Glu Met Lys Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr 
    50                  55                  60                  


Val Lys Met Leu Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu 
65                  70                  75                  80  


Lys Gly Asp Phe Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile 
                85                  90                  95      


Leu Arg Val Gln Val Asn His Glu Lys Asn Gln Asn Val His Met Glu 
            100                 105                 110         


Ser Glu Val Tyr Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser 
        115                 120                 125             


Gln Leu Phe Asp His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys 
    130                 135                 140                 


Arg Lys Ile Lys Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe 
145                 150                 155                 160 


Pro Cys Gln Gln Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr 
                165                 170                 175     


Lys Arg Phe Lys Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu 
            180                 185                 190         


Leu Asn Lys Ala Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val 
        195                 200                 205             


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp 
    210                 215                 220                 


Asp Gln His Cys Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala 
225                 230                 235                 240 


Cys Tyr Met Glu Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu 
                245                 250                 255     


Gly Arg Met Cys Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly 
            260                 265                 270         


Ser Leu Glu Asp Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly 
        275                 280                 285             


Ser Leu Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met 
    290                 295                 300                 


Tyr Leu Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu 
305                 310                 315                 320 


Gly Leu Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly 
                325                 330                 335     


Lys Phe Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly 
            340                 345                 350         


Leu His Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser 
        355                 360                 365             


Asp Asp Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe 
    370                 375                 380                 


Arg Ser Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg 
385                 390                 395                 400 


Leu Arg Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val 
                405                 410                 415     


Asp Gly Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His 
            420                 425                 430         


Lys Thr Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu 
        435                 440                 445             


Ser Glu Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala 
    450                 455                 460                 


Tyr Arg Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His 
465                 470                 475                 480 


Phe His Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg 
                485                 490                 495     


Ala Glu Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val 
            500                 505                 510         


Val Lys Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu 
        515                 520                 525             


Asn Gly Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val 
    530                 535                 540                 


Leu Leu Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His 
545                 550                 555                 560 


Asn Lys Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu 
                565                 570                 575     


Glu Leu Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr 
            580                 585                 590         


Met Gly Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe 
        595                 600                 605             


Pro Cys Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr 
    610                 615                 620                 


Lys Gly Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu 
625                 630                 635                 640 


Leu Arg Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val 
                645                 650                 655     


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu 
            660                 665                 670         


Glu Pro Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala 
        675                 680                 685             


Cys Tyr Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln 
    690                 695                 700                 


Gly Gln Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly 
705                 710                 715                 720 


Cys Leu Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr 
                725                 730                 735     


Ser Leu Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met 
            740                 745                 750         


Tyr Leu Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys 
        755                 760                 765             


Gly Phe Leu Phe Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly 
    770                 775                 780                 


Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala 
785                 790                 795                 800 


Leu Leu Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr 
                805                 810                 815     


Cys Asp Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg 
            820                 825                 830         


Arg Ala Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys 
        835                 840                 845             


Ile Arg Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val 
    850                 855                 860                 


Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His 
865                 870                 875                 880 


Gln Thr Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu 
                885                 890                 895     


Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly 
            900                 905                 910         


Val Arg Leu Arg Thr Glu Ala Ser Ser 
        915                 920     


<210>  4
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Lys Arg Ala Leu Arg Asp Phe Ile Asp Lys Tyr Leu Tyr Ala 
1               5                   10                  15      


Met Arg Leu Ser Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg 
            20                  25                  30          


Lys Glu Met Lys Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr 
        35                  40                  45              


Val Lys Met Leu Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu 
    50                  55                  60                  


Lys Gly Asp Phe Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile 
65                  70                  75                  80  


Leu Arg Val Gln Val Asn His Glu Lys Asn Gln Asn Val His Met Glu 
                85                  90                  95      


Ser Glu Val Tyr Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser 
            100                 105                 110         


Gln Leu Phe Asp His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys 
        115                 120                 125             


Arg Lys Ile Lys Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe 
    130                 135                 140                 


Pro Cys Gln Gln Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr 
145                 150                 155                 160 


Lys Arg Phe Lys Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu 
                165                 170                 175     


Leu Asn Lys Ala Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val 
            180                 185                 190         


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp 
        195                 200                 205             


Asp Gln His Cys Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala 
    210                 215                 220                 


Cys Tyr Met Glu Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu 
225                 230                 235                 240 


Gly Arg Met Cys Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly 
                245                 250                 255     


Ser Leu Glu Asp Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly 
            260                 265                 270         


Ser Leu Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met 
        275                 280                 285             


Tyr Leu Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu 
    290                 295                 300                 


Gly Leu Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly 
305                 310                 315                 320 


Lys Phe Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly 
                325                 330                 335     


Leu His Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser 
            340                 345                 350         


Asp Asp Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe 
        355                 360                 365             


Arg Ser Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg 
    370                 375                 380                 


Leu Arg Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val 
385                 390                 395                 400 


Asp Gly Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His 
                405                 410                 415     


Lys Thr Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu 
            420                 425                 430         


Ser Glu Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala 
        435                 440                 445             


Tyr Arg Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His 
    450                 455                 460                 


Phe His Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg 
465                 470                 475                 480 


Ala Glu Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val 
                485                 490                 495     


Val Lys Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu 
            500                 505                 510         


Asn Gly Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val 
        515                 520                 525             


Leu Leu Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His 
    530                 535                 540                 


Asn Lys Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu 
545                 550                 555                 560 


Glu Leu Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr 
                565                 570                 575     


Met Gly Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe 
            580                 585                 590         


Pro Cys Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr 
        595                 600                 605             


Lys Gly Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu 
    610                 615                 620                 


Leu Arg Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val 
625                 630                 635                 640 


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu 
                645                 650                 655     


Glu Pro Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala 
            660                 665                 670         


Cys Tyr Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln 
        675                 680                 685             


Gly Gln Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly 
    690                 695                 700                 


Cys Leu Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr 
705                 710                 715                 720 


Ser Leu Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met 
                725                 730                 735     


Tyr Leu Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys 
            740                 745                 750         


Gly Phe Leu Phe Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly 
        755                 760                 765             


Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala 
    770                 775                 780                 


Leu Leu Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr 
785                 790                 795                 800 


Cys Asp Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg 
                805                 810                 815     


Arg Ala Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys 
            820                 825                 830         


Ile Arg Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val 
        835                 840                 845             


Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His 
    850                 855                 860                 


Gln Thr Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu 
865                 870                 875                 880 


Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly 
                885                 890                 895     


Val Arg Leu Arg Thr Glu Ala Ser Ser 
            900                 905 


<210>  5
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His 
1               5                   10                  15      


Asp Gln Val Gln Lys Val Asp Gln Tyr Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Leu Glu Ile Ser Lys Arg Phe Arg Lys Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe 
65                  70                  75                  80  


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Trp Val Lys 
                85                  90                  95      


Val Thr Asp Asn Gly Leu Gln Lys Val Glu Met Glu Asn Gln Ile Tyr 
            100                 105                 110         


Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp 
        115                 120                 125             


His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
145                 150                 155                 160 


Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys 
                165                 170                 175     


Ser Ser Gly Val Glu Gly Arg Asp Val Val Ala Leu Ile Arg Lys Ala 
            180                 185                 190         


Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp His Asn Cys 
    210                 215                 220                 


Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Asn Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Gln Glu Ile Asp Met Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Glu Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Lys Leu Ser Pro Glu Leu Leu Asn Thr Gly Arg Phe Glu Thr 
                325                 330                 335     


Lys Asp Ile Ser Asp Ile Glu Gly Glu Lys Asp Gly Ile Arg Lys Ala 
            340                 345                 350         


Arg Glu Val Leu Met Arg Leu Gly Leu Asp Pro Thr Gln Glu Asp Cys 
        355                 360                 365             


Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser 
    370                 375                 380                 


Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Gln Arg Ile Lys Glu Asn 
385                 390                 395                 400 


Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val 
                405                 410                 415     


Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Thr Val Arg 
            420                 425                 430         


Arg Leu Val Pro Gly Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu His Leu Gln Leu Ser 
465                 470                 475                 480 


His Asp Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu 
                485                 490                 495     


Arg Gly Leu Ser Lys Glu Thr His Ala Ser Ala Pro Val Lys Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg 
    530                 535                 540                 


Val Arg Asn Gly Lys Trp Gly Gly Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Gln Glu Val Met His Gly Thr Gly Asp Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys 
            580                 585                 590         


Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Asn Ser Leu Asp Glu Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala 
625                 630                 635                 640 


Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Gly Phe Glu Asp Pro His Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Arg Asn Val Glu Leu Val Glu Gly Glu Glu Gly Arg Met Cys 
    690                 695                 700                 


Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Phe Arg Thr Glu Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro 
                725                 730                 735     


Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe 
        755                 760                 765             


Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Arg Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Ala Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Lys 
865                 870                 875                 880 


Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Gln Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg 
            900                 905                 910         


Glu Ala Gly Gln Arg 
        915         


<210>  6
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr 
            20                  25  


<210>  7
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Cys Glu His Ser Leu Ser Leu Pro Cys Arg Gly Ala Glu Ala 
1               5                   10                  15      


Trp Glu Ile Gly Ile Asp Lys Tyr Leu 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Gln Ile Cys Gln Arg Glu Ser Ala Thr Ala Ala Glu Lys Pro 
1               5                   10                  15      


Lys Leu His Leu Leu Ala Glu Ser Glu 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Lys Arg Ala Leu Arg Asp Phe Ile Asp Lys Tyr Leu Tyr Ala 
1               5                   10                  15      


Met Arg Leu Ser Asp Glu Thr Leu Ile 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His 
1               5                   10                  15      


Asp Gln Val Gln Lys Val Asp Gln Tyr 
            20                  25  


