                               SEQUENCE LISTING

<110> TR1X, INC.
 
<120> POLY-DONOR CD4+ T CELLS EXPRESSING IL-10 AND USES THEREOF

<130> 37104-46592/WO

<140> PCT/US2021/039464
<141> 2021-06-28

<150> PCT/US2020/040372
<151> 2020-06-30

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 178
<212> PRT
<213> Homo sapiens

<400> 1
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 2
<211> 498
<212> DNA
<213> Homo sapiens

<400> 2
ggggtgaggg ccagcccagg ccagggcacc cagtctgaga acagctgcac ccacttccca       60

ggcaacctgc ctaacatgct tcgagatctc cgagatgcct tcagcagagt gaagactttc      120

tttcaaatga aggatcagct ggacaacttg ttgttaaagg agtccttgct ggaggacttt      180

aagggttacc tgggttgcca agccttgtct gagatgatcc agttttacct ggaggaggtg      240

atgccccaag ctgagaacca agacccagac atcaaggcgc atgtgaactc cctgggggag      300

aacctgaaga ccctcaggct gaggctacgg cgctgtcatc gatttcttcc ctgtgaaaac      360

aagagcaagg ccgtggagca ggtgaagaat gcctttaata agctccaaga gaaaggcatc      420

tacaaagcca tgagtgagtt tgacatcttc atcaactaca tagaagccta catgacaatg      480

aagatacgaa actgagtc                                                    498


<210> 3
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Leu Glu Asp Pro Pro Val Pro Pro Leu Glu Gly Tyr Val Gly His Lys 
1               5                   10                  15      


Ala His Asn His Ser Ser Gln Asp Gly Ala Ile Asp Arg Asp Glu Val 
            20                  25                  30          


Val Gly Gly Ala Ser Gly His His Gly Leu Gly Ala Ala His His Cys 
        35                  40                  45              


Gly His His Thr Cys His Arg Ala Gly Tyr Glu Val Leu Phe Trp Arg 
    50                  55                  60                  


Cys Leu Arg Leu Leu Gly Ala Gly Gly Cys Ala Val Arg Ala Leu Trp 
65                  70                  75                  80  


Gly Cys Gly Pro Cys Asn Pro Thr Ala Arg Asp Leu Leu Ala Leu Gly 
                85                  90                  95      


Val Gly Pro Ala Cys Ala Leu Ala Glu Leu Ala Leu Gly Val Leu Ala 
            100                 105                 110         


His Gly Ala Gly Gln Ala Arg Val His Val Val Gly Leu Val Gly Ile 
        115                 120                 125             


Arg Ala Val Gly Ala Leu Leu Ala His Gly Val Leu Leu Val Leu Ala 
    130                 135                 140                 


Gly Glu His Glu Ala Arg Ala Arg Leu Ala His Ala Ala Arg Leu Ala 
145                 150                 155                 160 


Ala Pro Ser Arg Leu Ile Leu Val Val Ala Val Gly Ala Ala Ala His 
                165                 170                 175     


Gly Val Val Gly Leu His Ala Arg Arg Arg His Ala Leu Glu Pro His 
            180                 185                 190         


Ala Leu Gly Ala Arg Leu Ala Arg Leu Gly Arg Ala His His Val Gly 
        195                 200                 205             


Glu Arg His Ala Val Gln Ala Gly Leu Thr His Gly Leu Val Gly Ser 
    210                 215                 220                 


Thr Arg Leu Gly His Thr Leu Ala Gln Val Ala Gly Phe Ala Ala Leu 
225                 230                 235                 240 


Thr Ala Val Cys Val Gln Ala Cys Gly Ala Cys Leu Leu Gly Thr Ser 
                245                 250                 255     


Lys Gly His Pro Gln Lys Gln Gln Gln Gln Gln Ala Arg Pro Val His 
            260                 265                 270         


Gly Ala Ala Gly Gly Thr Cys Pro His 
        275                 280     


<210> 4
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
ctagaggatc cccctgttcc acctcttgaa ggctatgtag gccacaaggc ccacaaccac       60

agcagccagg atggagcaat agacagggat gaggttgtcg gtggtgcctc gggtcaccac      120

gggctgggag ctgcccatca ctgtggtcac cacacctgcc accgtgctgg ctatgaggtc      180

ttgttctgga ggtgcctcag gctcctgggt gctgggggct gtgctgtccg agccctctgg      240

gggtgtggac cgtgtaatcc aacggccagg gatctcctcg cactcggcgt cggcccagcg      300

tgtgcactcg cggagctggc gctcggtgtc ctcgcacacg gtgcagggca ggcacgggtc      360

cacgtggttg gcctcgtcgg aatacgtgcc gtcggggcac tcctcgcaca cggtgttctg      420

cttgtcctgg caggagaaca cgaggcccga gcccgcctcg cacacgcggc acgcctcgca      480

gcgcccagtc gtctcatcct ggtagtagcc gtaggcgcag cggcacacgg cgtcgtcggc      540

ctccacgcac ggcgccgaca tgctctggag ccccacgcac tcggtgcacg gcttgcacgg      600

ctcggtcgcg ctcaccacgt cggagaacgt cacgctgtcc aggcagggct cacacacggt      660

ctggttggct ccacaaggct gggccacacc ctcgcccagg ttgcaggctt tgcagcactc      720

accgctgtgt gtgtacaggc ctgtggggca tgcctccttg gcacctccaa gggacacccc      780

cagaagcagc aacagcagca ggcgcggccc gtccatggcg cggccggtgg cacctgcccc      840

cat                                                                    843


<210> 5
<211> 9025
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat       60

caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc cagttccgcc      120

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg      180

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcgtc      240

gagacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt      300

tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc      360

cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt      420

tgcgcagcct gaatggcgaa tggcgcgacg cgccctgtag cggcgcatta agcgcggcgg      480

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt      540

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc      600

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg      660

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga      720

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc      780

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa      840

aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa      900

tttcccaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta      960

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     1020

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     1080

ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga     1140

agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct     1200

tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg     1260

tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta     1320

ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat     1380

gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt     1440

acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga     1500

tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga     1560

gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga     1620

actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc     1680

aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc     1740

cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg     1800

tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat     1860

cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata     1920

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     1980

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     2040

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg     2100

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc     2160

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct     2220

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc     2280

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt     2340

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg     2400

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct     2460

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag     2520

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag     2580

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg     2640

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg     2700

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac     2760

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt     2820

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat     2880

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc     2940

aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc     3000

tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca     3060

tgattacgcc aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctgcaagc     3120

ttggccattg catacgttgt atccatatca taatatgtac atttatattg gctcatgtcc     3180

aacattaccg ccatgttgac attgattatt gactagttat taatagtaat caattacggg     3240

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc     3300

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat     3360

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc     3420

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga     3480

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg     3540

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat     3600

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt     3660

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc     3720

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc     3780

tcgtttagtg aaccggggtc tctctggtta gaccagatct gagcctggga gctctctggc     3840

taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg     3900

tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg     3960

tggaaaatct ctagcagtgg cgcccgaaca gggacctgaa agcgaaaggg aaaccagagc     4020

tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac     4080

tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga     4140

gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag     4200

ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat     4260

tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc     4320

tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa     4380

ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga     4440

tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga     4500

cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta     4560

aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa     4620

aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact     4680

atgggcgcag cctcaatgac gctgacggta caggccagac aattattgtc tggtatagtg     4740

cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca     4800

gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat     4860

caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct     4920

tggaatgcta gttggagtaa taaatctctg gaacagattg gaatcacacg acctggatgg     4980

agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt gaagaatcgc     5040

aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg gcaagtttgt     5100

ggaattggtt taacataaca aattggctgt ggtatataaa attattcata atgatagtag     5160

gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat agagttaggc     5220

agggatattc accattatcg tttcagaccc acctcccaac cccgagggga cccgacaggc     5280

ccgaaggaat agaagaagaa ggtggagaga gagacagaga cagatccatt cgattagtga     5340

acggatctcg acggtatcgg ttaactttta aaagaaaagg ggggattggg gggtacagtg     5400

caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac     5460

aaattacaaa aattcaaaat tttatcgatc acgagactag cctcgagaga tctgatcata     5520

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     5580

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     5640

aatggttaca aataaggcaa tagcatcaca aatttcacaa ataaggcatt tttttcactg     5700

cattctagtt ttggtttgtc caaactcatc aatgtatctt atcatgtctg gatctcaaat     5760

ccctcggaag ctgcgcctgt catcgaattc ctgcagcccg gtgcatgact aagctagctc     5820

agttagcctc ccccatctcc cctagaggat ccccctgttc cacctcttga aggctatgta     5880

ggccacaagg cccacaacca cagcagccag gatggagcaa tagacaggga tgaggttgtc     5940

ggtggtgcct cgggtcacca cgggctggga gctgcccatc actgtggtca ccacacctgc     6000

caccgtgctg gctatgaggt cttgttctgg aggtgcctca ggctcctggg tgctgggggc     6060

tgtgctgtcc gagccctctg ggggtgtgga ccgtgtaatc caacggccag ggatctcctc     6120

gcactcggcg tcggcccagc gtgtgcactc gcggagctgg cgctcggtgt cctcgcacac     6180

ggtgcagggc aggcacgggt ccacgtggtt ggcctcgtcg gaatacgtgc cgtcggggca     6240

ctcctcgcac acggtgttct gcttgtcctg gcaggagaac acgaggcccg agcccgcctc     6300

gcacacgcgg cacgcctcgc agcgcccagt cgtctcatcc tggtagtagc cgtaggcgca     6360

gcggcacacg gcgtcgtcgg cctccacgca cggcgccgac atgctctgga gccccacgca     6420

ctcggtgcac ggcttgcacg gctcggtcgc gctcaccacg tcggagaacg tcacgctgtc     6480

caggcagggc tcacacacgg tctggttggc tccacaaggc tgggccacac cctcgcccag     6540

gttgcaggct ttgcagcact caccgctgtg tgtgtacagg cctgtggggc atgcctcctt     6600

ggcacctcca agggacaccc ccagaagcag caacagcagc aggcgcggcc cgtccatggc     6660

gcggccggtg gcacctgccc ccatcgcccg cctcccgcgg cagcgctcga cttccagctc     6720

ggtccgcttt gcggactgat ggggctgcgc tgcgctgcgc tccagcgccc cccctgcccg     6780

ccggagctgg ccgcggcccg aattccgcgg aggctggatc ggtcccggtg tcttctatgg     6840

aggtcaaaac agcgtggatg gcgtctccag gcgatctgac ggttcactaa acgagctctg     6900

cttatatagg cctcccaccg tacacgccta ccctcgagaa gcttgatatc gaattcccac     6960

ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc     7020

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc     7080

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc     7140

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac     7200

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc     7260

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcggggcgcg ccgagagcag     7320

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct     7380

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct     7440

cgttgaccga atcaccgacc tctctcccca gggggatccc cggtctgcag gaattcatgc     7500

acagctcagc actgctctgt tgcctggtcc tcctgactgg ggtgagggcc agcccaggcc     7560

agggcaccca gtctgagaac agctgcaccc acttcccagg caacctgcct aacatgcttc     7620

gagatctccg agatgccttc agcagagtga agactttctt tcaaatgaag gatcagctgg     7680

acaacttgtt gttaaaggag tccttgctgg aggactttaa gggttacctg ggttgccaag     7740

ccttgtctga gatgatccag ttttacctgg aggaggtgat gccccaagct gagaaccaag     7800

acccagacat caaggcgcat gtgaactccc tgggggagaa cctgaagacc ctcaggctga     7860

ggctacggcg ctgtcatcga tttcttccct gtgaaaacaa gagcaaggcc gtggagcagg     7920

tgaagaatgc ctttaataag ctccaagaga aaggcatcta caaagccatg agtgagtttg     7980

acatcttcat caactacata gaagcctaca tgacaatgaa gatacgaaac tgagtcgaga     8040

atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc     8100

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta     8160

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt     8220

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg     8280

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta     8340

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt     8400

tgggcactga caattccgtg gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg     8460

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca     8520

atccagcgga ccttccttcc cgcggcctgc tgccggctct agagcctctt ccgcgtcttc     8580

gccttcccgg gtcgagctcg gtacctttaa gaccaatgac ttacaaggca gctgtagatc     8640

ttagccactt tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac     8700

aagatctgct ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc     8760

tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc     8820

aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt     8880

agtcagtgtg gaaaatctct agcagtagta gttcatgtca tcttattatt cagtatttat     8940

aacttgcaaa gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg     9000

gttacaaata aagcaatagc atcac                                           9025


