                         SEQUENCE LISTING

<110>  Bar-Ilan University
       LEVANON, Erez
       BEN-AROYA, Shay
 
<120>  COMPOSITION AND METHODS FOR IDENTIFYING ANTISENSE GUIDE RNA FOR 
       RNA EDITING

<130>  88549

<150>  US 63/045,216
<151>  2020-06-29

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (21)..(53)
<223>  n is a, c, g, or t

<400>  1
ttaagaaaat ccttgcttaa nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnaaagatt       60

ctcttttttt atg                                                          73


<210>  2
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ccgaagtcgg tgatgctgtc gccgaagaag ttaagaaaat ccttgcttaa                  50


<210>  3
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
atttcattta taaagtttat gtacaaatat cataaaaaaa gagaatcttt                  50


<210>  4
<211>  1861
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LEU2 nucleic acid sequence

<400>  4
aactgtggga atactcaggt atcgtaagat gcaagagttc gaatctctta gcaaccatta       60

tttttttcct caacataacg agaacacaca ggggcgctat cgcacagaat caaattcgat      120

gactggaaat tttttgttaa tttcagaggt cgcctgacgc atataccttt ttcaactgaa      180

aaattgggag aaaaaggaaa ggtgagagcg ccggaaccgg cttttcatat agaatagaga      240

agcgttcatg actaaatgct tgcatcacaa tacttgaagt tgacaatatt atttaaggac      300

ctattgtttt ttccaatagg tggttagcaa tcgtcttact ttctaacttt tcttaccttt      360

tacatttcag caatatatat atatatattt caaggatata ccattctaat gtctgcccct      420

aagaagatcg tcgttttgcc aggtgaccac gttggtcaag aaatcacagc cgaagccatt      480

aaggttctta aagctatttc tgatgttcgt tccaatgtca agttcgattt cgaaaatcat      540

ttaattggtg gtgctgctat cgatgctaca ggtgttccac ttccagatga ggcgctggaa      600

gcctccaaga aggctgatgc cgttttgtta ggtgctgtgg gtggtcctaa atggggtacc      660

ggtagtgtta gacctgaaca aggtttacta aaaatccgta aagaacttca attgtacgcc      720

aacttaagac catgtaactt tgcatccgac tctcttttag acttatctcc aatcaagcca      780

caatttgcta aaggtactga cttcgttgtt gtcagagaat tagtgggagg tatttacttt      840

ggtaagagaa aggaagacga tggtgatggt gtcgcttggg atagtgaaca atacaccgtt      900

ccagaagtgc aaagaatcac aagaatggcc gctttcatgg ccctacaaca tgagccacca      960

ttgcctattt ggtccttgga taaagctaat gttttggcct cttcaagatt atggagaaaa     1020

actgtggagg aaaccatcaa gaacgaattc cctacattga aggttcaaca tcaattgatt     1080

gattctgccg ccatgatcct agttaagaac ccaacccacc taaatggtat tataatcacc     1140

agcaacatgt ttggtgatat catctccgat gaagcctccg ttatcccagg ttccttgggt     1200

ttgttgccat ctgcgtcctt ggcctctttg ccagacaaga acaccgcatt tggtttgtac     1260

gaaccatgcc acggttctgc tccagatttg ccaaagaata aggtcaaccc tatcgccact     1320

atcttgtctg ctgcaatgat gttgaaattg tcattgaact tgcctgaaga aggtaaggcc     1380

attgaagatg cagttaaaaa ggttttggat gcaggtatca gaactggtga tttaggtggt     1440

tccaacagta ccaccgaagt cggtgatgct gtcgccgaag aagttaagaa aatccttgct     1500

taaaaagatt ctcttttttt atgatatttg tacataaact ttataaatga aattcataat     1560

agaaacgaca cgaaattaca aaatggaata tgttcatagg gtagacgaaa ctatatacgc     1620

aatctacata catttatcaa gaaggagaaa aaggaggatg taaaggaata caggtaagca     1680

aattgatact aatggctcaa cgtgataagg aaaaagaatt gcactttaac attaatattg     1740

acaaggagga gggcaccaca caaaaagtta ggtgtaacag aaaatcatga aactatgatt     1800

cctaatttat atattggagg attttctcta aaaaaaaaaa aatacaacaa ataaaaaaca     1860

c                                                                     1861


<210>  5
<211>  675
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRP1 nucleic acid sequence

<400>  5
atgtctgtta ttaatttcac aggtagttct ggtccattgg tgaaagtttg cggcttgcag       60

agcacagagg ccgcagaatg tgctctagat tccgatgctg acttgctggg tattatatgt      120

gtgcccaata gaaagagaac aattgacccg gttattgcaa ggaaaatttc aagtcttgta      180

aaagcatata aaaatagttc aggcactccg aaatacttgg ttggcgtgtt tcgtaatcaa      240

cctaaggagg atgttttggc tctggtcaat gattacggca ttgatatcgt ccaactgcat      300

ggagatgagt cgtggcaaga ataccaagag ttcctcggtt tgccagttat taaaagactc      360

gtatttccaa aagactgcaa catactactc agtgcagctt cacagaaacc tcattcgttt      420

attcccttgt ttgattcaga agcaggtggg acaggtgaac ttttggattg gaactcgatt      480

tctgactggg ttggaaggca agagagcccc gaaagcttac attttatgtt agctggtgga      540

ctgacgccag aaaatgttgg tgatgcgctt agattaaatg gcgttattgg tgttgatgta      600

agcggaggtg tggagacaaa tggtgtaaaa gactctaaca aaatagcaaa tttcgtcaaa      660

aatgctaaga aatag                                                       675


<210>  6
<211>  1716
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ADE2 nucleic acid sequence

<400>  6
atggattcta gaacagttgg tatattagga gggggacaat tgggacgtat gattgttgag       60

gcagcaaaca ggctcaacat taagacggta atactagatg ctgaaaattc tcctgccaaa      120

caaataagca actccaatga ccacgttaat ggctcctttt ccaatcctct tgatatcgaa      180

aaactagctg aaaaatgtga tgtgctaacg attgagattg agcatgttga tgttcctaca      240

ctaaagaatc ttcaagtaaa acatcccaaa ttaaaaattt acccttctcc agaaacaatc      300

agattgatac aagacaaata tattcaaaaa gagcatttaa tcaaaaatgg tatagcagtt      360

acccaaagtg ttcctgtgga acaagccagt gagacgtccc tattgaatgt tggaagagat      420

ttgggttttc cattcgtctt gaagtcgagg actttggcat acgatggaag aggtaacttc      480

gttgtaaaga ataaggaaat gattccggaa gctttggaag tactgaagga tcgtcctttg      540

tacgccgaaa aatgggcacc atttactaaa gaattagcag tcatgattgt gagatctgtt      600

aacggtttag tgttttctta cccaattgta gagactatcc acaaggacaa tatttgtgac      660

ttatgttatg cgcctgctag agttccggac tccgttcaac ttaaggcgaa gttgttggca      720

gaaaatgcaa tcaaatcttt tcccggttgt ggtatatttg gtgtggaaat gttctattta      780

gaaacagggg aattgcttat taacgaaatt gccccaaggc ctcacaactc tggacattat      840

accattgatg cttgcgtcac ttctcaattt gaagctcatt tgagatcaat attggatttg      900

ccaatgccaa agaatttcac atctttctcc accattacaa cgaacgccat tatgctaaat      960

gttcttggag acaaacatac aaaagataaa gagctagaaa cttgcgaaag agcattggcg     1020

actccaggtt cctcagtgta cttatatgga aaagagtcta gacctaacag aaaagtaggt     1080

cacataaata ttattgcctc cagtatggcg gaatgtgaac aaaggctgaa ctacattaca     1140

ggtagaactg atattccaat caaaatctct gtcgctcaaa agttggactt ggaagcaatg     1200

gtcaaaccat tggttggaat catcatggga tcagactctg acttgccggt aatgtctgcc     1260

gcatgtgcgg ttttaaaaga ttttggcgtt ccatttgaag tgacaatagt ctctgctcat     1320

agaactccac ataggatgtc agcatatgct atttccgcaa gcaagcgtgg aattaaaaca     1380

attatcgctg gagctggtgg ggctgctcac ttgccaggta tggtggctgc aatgacacca     1440

cttcctgtca tcggtgtgcc cgtaaaaggt tcttgtctag atggagtaga ttctttacat     1500

tcaattgtgc aaatgcctag aggtgttcca gtagctaccg tcgctattaa taatagtacg     1560

aacgctgcgc tgttggctgt cagactgctt ggcgcttatg attcaagtta tacaacgaaa     1620

atggaacagt ttttattaaa gcaagaagaa gaagttcttg tcaaagcaca aaagttagaa     1680

actgtcggtt acgaagctta tctagaaaac aagtaa                               1716


<210>  7
<211>  4179
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LYS2 nucleic acid sequence

<400>  7
atgactaacg aaaaggtctg gatagagaag ttggataatc caactctttc agtgttacca       60

catgactttt tacgcccaca acaagaacct tatacgaaac aagctacata ttcgttacag      120

ctacctcagc tcgatgtgcc tcatgatagt ttttctaaca aatacgctgt cgctttgagt      180

gtatgggctg cattgatata tagagtaacc ggtgacgatg atattgttct ttatattgcg      240

aataacaaaa tcttaagatt caatattcaa ccaacgtggt catttaatga gctgtattct      300

acaattaaca atgagttgaa caagctcaat tctattgagg ccaatttttc ctttgacgag      360

ctagctgaaa aaattcaaag ttgccaagat ctggaaagga cccctcagtt gttccgtttg      420

gcctttttgg aaaaccaaga tttcaaatta gacgagttca agcatcattt agtggacttt      480

gctttgaatt tggataccag taataatgcg catgttttga acttaattta taacagctta      540

ctgtattcga atgaaagagt aaccattgtt gcggaccaat ttactcaata tttgactgct      600

gcgctaagcg atccatccaa ttgcataact aaaatctctc tgatcaccgc atcatccaag      660

gatagtttac ctgatccaac taagaacttg ggctggtgcg atttcgtggg gtgtattcac      720

gacattttcc aggacaatgc tgaagccttc ccagagagaa cctgtgttgt ggagactcca      780

acactaaatt ccgacaagtc ccgttctttc acttatcgcg acatcaaccg cacttctaac      840

atagttgccc attatttgat taaaacaggt atcaaaagag gtgatgtagt gatgatctat      900

tcttctaggg gtgtggattt gatggtatgt gtgatgggtg tcttgaaagc cggcgcaacc      960

ttttcagtta tcgaccctgc atatccccca gccagacaaa ccatttactt aggtgttgct     1020

aaaccacgtg ggttgattgt tattagagct gctggacaat tggatcaact agtagaagat     1080

tacatcaatg atgaattgga gattgtttca agaatcaatt ccatcgctat tcaagaaaat     1140

ggtaccattg aaggtggcaa attggacaat ggcgaggatg ttttggctcc atatgatcac     1200

tacaaagaca ccagaacagg tgttgtagtt ggaccagatt ccaacccaac cctatctttc     1260

acatctggtt ccgaaggtat tcctaagggt gttcttggta gacatttttc cttggcttat     1320

tatttcaatt ggatgtccaa aaggttcaac ttaacagaaa atgataaatt cacaatgctg     1380

agcggtattg cacatgatcc aattcaaaga gatatgttta caccattatt tttaggtgcc     1440

caattgtatg tccctactca agatgatatt ggtacaccgg gccgtttagc ggaatggatg     1500

agtaagtatg gttgcacagt tacccattta acacctgcca tgggtcaatt acttactgcc     1560

caagctacta caccattccc taagttacat catgcgttct ttgtgggtga cattttaaca     1620

aaacgtgatt gtctgaggtt acaaaccttg gcagaaaatt gccgtattgt taatatgtac     1680

ggtaccactg aaacacagcg tgcagtttct tatttcgaag ttaaatcaaa aaatgacgat     1740

ccaaactttt tgaaaaaatt gaaagatgtc atgcctgctg gtaaaggtat gttgaacgtt     1800

cagctactag ttgttaacag gaacgatcgt actcaaatat gtggtattgg cgaaataggt     1860

gagatttatg ttcgtgcagg tggtttggcc gaaggttata gaggattacc agaattgaat     1920

aaagaaaaat ttgtgaacaa ctggtttgtt gaaaaagatc actggaatta tttggataag     1980

gataatggtg aaccttggag acaattctgg ttaggtccaa gagatagatt gtacagaacg     2040

ggtgatttag gtcgttatct accaaacggt gactgtgaat gttgcggtag ggctgatgat     2100

caagttaaaa ttcgtgggtt cagaatcgaa ttaggagaaa tagatacgca catttcccaa     2160

catccattgg taagagaaaa cattacttta gttcgcaaaa atgccgacaa tgagccaaca     2220

ttgatcacat ttatggtccc aagatttgac aagccagatg acttgtctaa gttccaaagt     2280

gatgttccaa aggaggttga aactgaccct atagttaagg gcttaatcgg ttaccatctt     2340

ttatccaagg acatcaggac tttcttaaag aaaagattgg ctagctatgc tatgccttcc     2400

ttgattgtgg ttatggataa actaccattg aatccaaatg gtaaagttga taagcctaaa     2460

cttcaattcc caactcccaa gcaattaaat ttggtagctg aaaatacagt ttctgaaact     2520

gacgactctc agtttaccaa tgttgagcgc gaggttagag acttatggtt aagtatatta     2580

cctaccaagc cagcatctgt atcaccagat gattcgtttt tcgatttagg tggtcattct     2640

atcttggcta ccaaaatgat ttttacctta aagaaaaagc tgcaagttga tttaccattg     2700

ggcacaattt tcaagtatcc aacgataaag gcctttgccg cggaaattga cagaattaaa     2760

tcatcgggtg gatcatctca aggtgaggtc gtcgaaaatg tcactgcaaa ttatgcggaa     2820

gacgccaaga aattggttga gacgctacca agttcgtacc cctctcgaga atattttgtt     2880

gaacctaata gtgccgaagg aaaaacaaca attaatgtgt ttgttaccgg tgtcacagga     2940

tttctgggct cctacatcct tgcagatttg ttaggacgtt ctccaaagaa ctacagtttc     3000

aaagtgtttg cccacgtcag ggccaaggat gaagaagctg catttgcaag attacaaaag     3060

gcaggtatca cctatggtac ttggaacgaa aaatttgcct caaatattaa agttgtatta     3120

ggcgatttat ctaaaagcca atttggtctt tcagatgaga agtggatgga tttggcaaac     3180

acagttgata taattatcca taatggtgcg ttagttcact gggtttatcc atatgccaaa     3240

ttgagggatc caaatgttat ttcaactatc aatgttatga gcttagccgc cgtcggcaag     3300

ccaaagttct ttgactttgt ttcctccact tctactcttg acactgaata ctactttaat     3360

ttgtcagata aacttgttag cgaagggaag ccaggcattt tagaatcaga cgatttaatg     3420

aactctgcaa gcgggctcac tggtggatat ggtcagtcca aatgggctgc tgagtacatc     3480

attagacgtg caggtgaaag gggcctacgt gggtgtattg tcagaccagg ttacgtaaca     3540

ggtgcctctg ccaatggttc ttcaaacaca gatgatttct tattgagatt tttgaaaggt     3600

tcagtccaat taggtaagat tccagatatc gaaaattccg tgaatatggt tccagtagat     3660

catgttgctc gtgttgttgt tgctacgtct ttgaatcctc ccaaagaaaa tgaattggcc     3720

gttgctcaag taacgggtca cccaagaata ttattcaaag actacttgta tactttacac     3780

gattatggtt acgatgtcga aatcgaaagc tattctaaat ggaagaaatc attggaggcg     3840

tctgttattg acaggaatga agaaaatgcg ttgtatcctt tgctacacat ggtcttagac     3900

aacttacctg aaagtaccaa agctccggaa ctagacgata ggaacgccgt ggcatcttta     3960

aagaaagaca ccgcatggac aggtgttgat tggtctaatg gaataggtgt tactccagaa     4020

gaggttggta tatatattgc atttttaaac aaggttggat ttttacctcc accaactcat     4080

aatgacaaac ttccactgcc aagtatagaa ctaactcaag cgcaaataag tctagttgct     4140

tcaggtgctg gtgctcgtgg aagctccgca gcagcttaa                            4179


<210>  8
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  33 BP FRAGMENT INSERTED IN LEU2 REPORTE

<400>  8
ataactttgc aacagtgaag gaaagccttt gga                                    33


<210>  9
<211>  6692
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ADAR nucleic acid sequence

<400>  9
gcccctcctc ttggccaaac tttccggagg ggaaggcttt ccgaggaaac gaaagcgaaa       60

ttgaaccgga gccatcttgg gcccggcgcg cagacccgcg gagtttcccg tgccgacgcc      120

ccggggccac ttccagtgcg gagtagcgga ggcgtggggg cctcgagggg ctggcgcggc      180

ccagcggtcg ggccagggtc gtgccgccgg cgggtcgggc cgggcaatgc ctcgcgggcg      240

caatgaatcc gcggcagggg tattccctca gcggatacta cacccatcca tttcaaggct      300

atgagcacag acagctcagg taccagcagc ctgggccagg atcttccccc agtagtttcc      360

tgcttaagca aatagaattt ctcaaggggc agctcccaga agcaccggtg attggaaagc      420

agacaccgtc actgccacct tccctcccag gactccggcc aaggtttcca gtactacttg      480

cctccagtac cagaggcagg caagtggaca tcaggggtgt ccccaggggc gtgcatctcg      540

gaagtcaggg gctccagaga gggttccagc atccttcacc acgtggcagg agtctgccac      600

agagaggtgt tgattgcctt tcctcacatt tccaggaact gagtatctac caagatcagg      660

aacaaaggat cttaaagttc ctggaagagc ttggggaagg gaaggccacc acagcacatg      720

atctgtctgg gaaacttggg actccgaaga aagaaatcaa tcgagtttta tactccctgg      780

caaagaaggg caagctacag aaagaggcag gaacaccccc tttgtggaaa atcgcggtct      840

ccactcaggc ttggaaccag cacagcggag tggtaagacc agacggtcat agccaaggag      900

ccccaaactc agacccgagt ttggaaccgg aagacagaaa ctccacatct gtctcagaag      960

atcttcttga gccttttatt gcagtctcag ctcaggcttg gaaccagcac agcggagtgg     1020

taagaccaga cagtcatagc caaggatccc caaactcaga cccaggtttg gaacctgaag     1080

acagcaactc cacatctgcc ttggaagatc ctcttgagtt tttagacatg gccgagatca     1140

aggagaaaat ctgcgactat ctcttcaatg tgtctgactc ctctgccctg aatttggcta     1200

aaaatattgg ccttaccaag gcccgagata taaatgctgt gctaattgac atggaaaggc     1260

agggggatgt ctatagacaa gggacaaccc ctcccatatg gcatttgaca gacaagaagc     1320

gagagaggat gcaaatcaag agaaatacga acagtgttcc tgaaaccgct ccagctgcaa     1380

tccctgagac caaaagaaac gcagagttcc tcacctgtaa tatacccaca tcaaatgcct     1440

caaataacat ggtaaccaca gaaaaagtgg agaatgggca ggaacctgtc ataaagttag     1500

aaaacaggca agaggccaga ccagaaccag caagactgaa accacctgtt cattacaatg     1560

gcccctcaaa agcagggtat gttgactttg aaaatggcca gtgggccaca gatgacatcc     1620

cagatgactt gaatagtatc cgcgcagcac caggtgagtt tcgagccatc atggagatgc     1680

cctccttcta cagtcatggc ttgccacggt gttcacccta caagaaactg acagagtgcc     1740

agctgaagaa ccccatcagc gggctgttag aatatgccca gttcgctagt caaacctgtg     1800

agttcaacat gatagagcag agtggaccac cccatgaacc tcgatttaaa ttccaggttg     1860

tcatcaatgg ccgagagttt cccccagctg aagctggaag caagaaagtg gccaagcagg     1920

atgcagctat gaaagccatg acaattctgc tagaggaagc caaagccaag gacagtggaa     1980

aatcagaaga atcatcccac tattccacag agaaagaatc agagaagact gcagagtccc     2040

agacccccac cccttcagcc acatccttct tttctgggaa gagccccgtc accacactgc     2100

ttgagtgtat gcacaaattg gggaactcct gcgaattccg tctcctgtcc aaagaaggcc     2160

ctgcccatga acccaagttc caatactgtg ttgcagtggg agcccaaact ttccccagtg     2220

tgagtgctcc cagcaagaaa gtggcaaagc agatggccgc agaggaagcc atgaaggccc     2280

tgcatgggga ggcgaccaac tccatggctt ctgataacca gcctgaaggt atgatctcag     2340

agtcacttga taacttggaa tccatgatgc ccaacaaggt caggaagatt ggcgagctcg     2400

tgagatacct gaacaccaac cctgtgggtg gccttttgga gtacgcccgc tcccatggct     2460

ttgctgctga attcaagttg gtcgaccagt ccggacctcc tcacgagccc aagttcgttt     2520

accaagcaaa agttgggggt cgctggttcc cagccgtctg cgcacacagc aagaagcaag     2580

gcaagcagga agcagcagat gcggctctcc gtgtcttgat tggggagaac gagaaggcag     2640

aacgcatggg tttcacagag gtaaccccag tgacaggggc cagtctcaga agaactatgc     2700

tcctcctctc aaggtcccca gaagcacagc caaagacact ccctctcact ggcagcacct     2760

tccatgacca gatagccatg ctgagccacc ggtgcttcaa cactctgact aacagcttcc     2820

agccctcctt gctcggccgc aagattctgg ccgccatcat tatgaaaaaa gactctgagg     2880

acatgggtgt cgtcgtcagc ttgggaacag ggaatcgctg tgtgaaagga gattctctca     2940

gcctaaaagg agaaactgtc aatgactgcc atgcagaaat aatctcccgg agaggcttca     3000

tcaggtttct ctacagtgag ttaatgaaat acaactccca gactgcgaag gatagtatat     3060

ttgaacctgc taagggagga gaaaagctcc aaataaaaaa gactgtgtca ttccatctgt     3120

atatcagcac tgctccgtgt ggagatggcg ccctctttga caagtcctgc agcgaccgtg     3180

ctatggaaag cacagaatcc cgccactacc ctgtcttcga gaatcccaaa caaggaaagc     3240

tccgcaccaa ggtggagaac ggagaaggca caatccctgt ggaatccagt gacattgtgc     3300

ctacgtggga tggcattcgg ctcggggaga gactccgtac catgtcctgt agtgacaaaa     3360

tcctacgctg gaacgtgctg ggcctgcaag gggcactgtt gacccacttc ctgcagccca     3420

tttatctcaa atctgtcaca ttgggttacc ttttcagcca agggcatctg acccgtgcta     3480

tttgctgtcg tgtgacaaga gatgggagtg catttgagga tggactacga catcccttta     3540

ttgtcaacca ccccaaggtt ggcagagtca gcatatatga ttccaaaagg caatccggga     3600

agactaagga gacaagcgtc aactggtgtc tggctgatgg ctatgacctg gagatcctgg     3660

acggtaccag aggcactgtg gatgggccac ggaatgaatt gtcccgggtc tccaaaaaga     3720

acatttttct tctatttaag aagctctgct ccttccgtta ccgcagggat ctactgagac     3780

tctcctatgg tgaggccaag aaagctgccc gtgactacga gacggccaag aactacttca     3840

aaaaaggcct gaaggatatg ggctatggga actggattag caaaccccag gaggaaaaga     3900

acttttatct ctgcccagta tagtatgctc cagtgacaga tggattaggg tgtgtcatac     3960

tagggtgtga gagaggtagg tcgtagcatt cctcatcaca tggtcagggg attttttttt     4020

ctcctttttt tttcttttta agccataatt ggtgatactg aaaactttgg gttcccattt     4080

atcctgcttt ctttgggatt gctaggcaag gtctggccag gccccccttt tttcccccaa     4140

gtgaagaggc agaaacctaa gaagttatct tttctttcta cccaaagcat acatagtcac     4200

tgagcacctg cggtccattt cctcttaaaa gttttgtttt gatttgtttc catttccttt     4260

ccctttgtgt ttgctacact gacctcttgc ggtcttgatt aggtttcagt caactctgga     4320

tcatgtcagg gactgataat ttcatttgtg gattacgcag acccctctac ttcccctctt     4380

tcccttctga gattctttcc ttgtgatctg aatgtctcct tttccccctc agagggcaaa     4440

gaggtgaaca taaaggattt ggtgaaacat ttgtaagggt aggagttgaa aactgcagtt     4500

cccagtgcca cggaagtgtg attggagcct gcagataatg cccagccatc ctcccatcct     4560

gcactttagc cagctgcagg gcgggcaagg caaggaaagc tgcttccctg gaagtgtatc     4620

actttctccg gcagctggga agtctagaac cagccagact gggttaaggg agctgctcaa     4680

gcaatagcag aggtttcacc cggcaggatg acacagacca cttcccaggg agcacgggca     4740

tgccttggaa tattgccaag cttccagctg cctcttctcc taaagcattc ctaggaatat     4800

tttccccgcc aatgctgggc gtacacccta gccaacggga caaatcctag agggtataaa     4860

atcatctctg ctcagataat catgacttag caagaataag ggcaaaaaat cctgttggct     4920

taacgtcact gttccacccg gtgtaatatc tctcatgaca gtgacaccaa gggaagttga     4980

ctaagtcaca tgtaaattag gagtgtttta aagaatgcca tagatgttga ttcttaactg     5040

ctacagataa cctgtaattg agcagattta aaattcaggc atacttttcc atttatccaa     5100

gtgctttcat ttttccagat ggcttcagaa gtaggctcgt gggcagggcg cagacctgat     5160

ctttataggg ttgacataga aagcagtagt tgtgggtgaa agggcaggtt gtcttcaaac     5220

tctgtgaggt agaatccttt gtctatacct ccatgaacat tgactcgtgt gttcagagcc     5280

tttggcctct ctgtggagtc tggctctctg gctcctgtgc attctttgaa tagtcactcg     5340

taaaaactgt cagtgcttga aactgtttcc tttactcatg ttgaagggac tttgttggct     5400

tttagagtgt tggtcatgac tccaagagca gagcagggaa gagcccaagc atagacttgg     5460

tgccgtggtg atggctgcag tccagttttg tgatgctgct tttacgtgtc cctcgataac     5520

agtcagctag acacactcag gaggactact gaggctctgc gaccttcagg agctgagcct     5580

gcctctctcc tttagatgac agaccttcat ctgggaacgt gctgagccag caccctcaga     5640

tgatttccct ccaaactgct gactaggtca tcctctgtct ggtagagaca ttcacatctt     5700

tgcttttatt ctatgctctc tgtacttttg accaaaaatt gaccaaagta agaaaatgca     5760

agttctaaaa atagactaag gatgcctttg cagaacacca aagcatccca aggaactggt     5820

agggaagtgg cgcctgtctc ctggagtgga agaggcctgc tccctggctc tgggtctgct     5880

gggggcacag taaatcagtc ttggcaccca catccagggc agagaggtct gtggttctca     5940

gcatcagaag gcagcgcagc ccctctcctc ttcaggctac agggttgtca cctgctgagt     6000

cctcaggttg tttggcctct ctggtccatc ttgggcatta ggttctccag cagagctctg     6060

gccagctgcc tcttctttaa ctgggaacac aggctctcac aagatcagaa cccccactca     6120

cccccaagat cttatctagc aagcctgtag tattcagttt ctgttgtagg aagagagcga     6180

ggcatccctg aattccacgc atctgctgga aacgagccgt gtcagatcgc acatccctgc     6240

gcccccatgc ccctctgagt cacacaggac agaggaggca gagcttctgc ccactgttat     6300

cttcactttc tttgtccagt cttttgtttt taataagcag tgaccctccc tactcttctt     6360

tttaatgatt tttgtagttg atttgtctga actgtggcta ctgtgcattc cttgaataat     6420

cacttgtaaa aattgtcagt gcttgaagct gtttccttta ctcacattga agggacttcg     6480

ttggtttttt ggagtcttgg ttgtgactcc aagagcagag tgaggaagac ccccaagcat     6540

agactcgggt actgtgatga tggctgcagt ccagttttat gattctgctt ttatgtgtcc     6600

cttgataaca gtgacttaac aatatacatt cctcataaat aaaaaaaaaa caagaatctg     6660

aattcttaga aaaaaaaaaa aaaaaaaaaa aa                                   6692


<210>  10
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mutated Leu2 partial sequence (leu2W82X)

<400>  10
gtgggtggtc ctaaataggg taccggtagt gtt                                    33


<210>  11
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mutated Leu2 partial sequence (leu2W82X)

<400>  11
cacccaccag gatttatccc atggccatca caa                                    33


<210>  12
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutated Leu2 partial sequence (leu2W82X)

<400>  12

Val Gly Gly Pro Lys 
1               5   


<210>  13
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  wild-type Leu2 partial sequence

<400>  13
aacactaccg gtaccccatt taggaccacc cac                                    33


<210>  14
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  wild-type Leu2 partial sequence

<400>  14
ttgtgatggc catggggtaa atcctggtgg gtg                                    33


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  wild-type Leu2 partial sequence

<400>  15

Val Ser Gly Thr Gly Trp Lys Pro Gly Gly Val 
1               5                   10      


<210>  16
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tail nucleic acid sequence sequence

<400>  16
aatccttgct taaaacacta ccggtacccc atttaggacc acccac                      46


<210>  17
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tail nucleic acid sequence sequence

<400>  17
aatccttgct taaaacacta ccggtatccc atttaggacc acccac                      46


<210>  18
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tail nucleic acid sequence sequence

<400>  18
aatccttgct taaaacacta ccggtacccc atttaggccg acccac                      46


<210>  19
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tail nucleic acid sequence sequence

<400>  19
aatccttgct taaaacacta ctggtacccc atttagggcc acccac                      46


<210>  20
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tail nucleic acid sequence sequence

<400>  20
aatccttgct taaaacacta ccggtttccc atttaggacc acccac                      46


<210>  21
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mutated Leu2-CF partial sequence (leu2W82X)

<400>  21
ataactttgc aacagtgaag gaaagccttt ggat                                   34


<210>  22
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mutated Leu2-CF partial sequence (leu2W82X)

<400>  22
tattgaaacg ttgtcacttc ctttcggaaa ccta                                   34


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutated Leu2-CF partial sequence (leu2W82X)

<400>  23

Ile Thr Leu Gln Gln 
1               5   


<210>  24
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  wild-type Leu2-CF partial sequence

<400>  24
tccaaaggct ttcctccact gttgcaaagt tat                                    33


<210>  25
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  wild-type Leu2-CF partial sequence

<400>  25
aggtttccga aaggaggtga caacgtttca ata                                    33


<210>  26
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  wild-type Leu2-CF partial sequence

<400>  26

Gly Phe Ala Lys Arg Trp Gln Gln Leu Thr Ile 
1               5                   10      


<210>  27
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutated Leu2 partial sequence (leu2W82X)

<400>  27

Gly Thr Gly Ser Val 
1               5   


<210>  28
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutated Leu2-CF partial sequence (leu2W82X)

<400>  28

Arg Arg Lys Ala Phe Gly 
1               5       


