               SEQUENCE LISTING

<110> Fondazione Toscana Life Sciences

<120> Antibodies to Coronavirus

<130> BI5558R

<160> 344

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:1 CDR 1 of variable domain of Heavy chain of J08

<400> 1
Gly Gly Thr Phe Ser Ser Tyr Thr 
1               5               

<210> 2
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:2 CDR 2 of variable domain of Heavy chain of J08

<400> 2
Ile Ile Pro Ile Leu Asp Arg Val 
1               5               

<210> 3
<211> 20
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:3 CDR 3 of variable domain of Heavy chain of J08

<400> 3
Cys Ala Arg Arg Ala Ile Asp Ser Asp Thr Tyr Val Glu Gln Ser His 
1               5                   10                  15      
Phe Asp Tyr Trp 
            20  

<210> 4
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:4 CDR 1 of variable domain of Light chain of J08

<400> 4
Gln Ser Val Ser Ser Tyr 
1               5       

<210> 5
<400> 5
000

<210> 6
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:6 CDR 3 of variable domain of Light chain of J08

<400> 6
Cys Gln Gln Pro Leu Thr Phe 
1               5           

<210> 7
<211> 127
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:7 variable domain of Heavy chain of J08

<400> 7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Leu Asp Arg Val Met Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Ala Ile Asp Ser Asp Thr Tyr Val Glu Gln Ser His Phe 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125         

<210> 8
<211> 105
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:8 variable domain of Light chain of J08

<400> 8
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Pro Leu Thr Phe Gly Gly 
                85                  90                  95      
Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105 

<210> 9
<211> 474
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:9 Heavy chain of J08

<400> 9
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              
Ser Ser Tyr Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Arg Ile Ile Pro Ile Leu Asp Arg Val Met Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Arg Ala Ile Asp Ser Asp Thr Tyr Val Glu Gln 
        115                 120                 125             
Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 

<210> 10
<211> 228
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:10 Light chain of J08

<400> 10
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly Val 
1               5                   10                  15      
His Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            20                  25                  30          
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        35                  40                  45              
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu 
    50                  55                  60                  
Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                85                  90                  95      
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Pro Leu Thr Phe 
            100                 105                 110         
Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
        115                 120                 125             
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
    130                 135                 140                 
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
145                 150                 155                 160 
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
                165                 170                 175     
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
            180                 185                 190         
Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
        195                 200                 205             
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
    210                 215                 220                 
Arg Gly Glu Cys 
225             

<210> 11
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:11 J08_heavy_chain LeaderSequence

<400> 11
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 12
<211> 381
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:12 J08_heavy chain_Variable domain

<400> 12
caggtgcagc tggtgcaatc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc      60

tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttgatag agtaatgtac     180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac     240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagacgggcc     300

attgattccg acacctatgt tgaacaatcc cactttgact actggggcca gggaaccctt     360

gtcaccgtct cctcagcctc c                                               381


<210> 13
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:13 J08_heavy chain_Constant domain

<400> 13
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 14
<211> 1425
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:14 J08_heavy chain_Complete

<400> 14
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcaatctgg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc     120

tgcaaggctt ctggaggcac cttcagcagc tatactatca gctgggtgcg acaggcccct     180

ggacaagggc ttgagtggat gggaaggatc atccctatcc ttgatagagt aatgtacgca     240

cagaagttcc agggcagagt cacgattacc gcggacaaat ccacgagcac agcctacatg     300

gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag acgggccatt     360

gattccgaca cctatgttga acaatcccac tttgactact ggggccaggg aacccttgtc     420

accgtctcct cagcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag     480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaacct     540

gtgacggtct cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc     600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg     660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag     720

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa     780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag    1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca    1140

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat    1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc    1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac    1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac    1380

aaccactaca cgcagaagag cctctccctg tccccgggta aatga                    1425


<210> 15
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:15 J08 light chain LeaderSequence

<400> 15
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 16
<211> 315
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:16 J08_light_chain Variable Domain

<400> 16
gaaattgtga tgacgcagtc tccagccact ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct    120

ggccaggctc ccagcctcct catctatgat gcctccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cctctcactt tcggcggagg gaccaaggtg    300

gagatcaaac gaact                                                     315


<210> 17
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:17 J08_light_chain ConstantRegion

<400> 17
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 18
<211> 690
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:18 J08_light_kappa_complete_seq

<400> 18
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgaa      60

attgtgatga cgcagtctcc agccactctg tctttgtctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc     180

caggctccca gcctcctcat ctatgatgcc tccaacaggg ccactggcat cccagccagg     240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa     300

gattttgcag tttattactg tcagcagcct ctcactttcg gcggagggac caaggtggag     360

atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg     420

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa     480

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag     540

caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac     600

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc     660

acaaagagct tcaacagggg agagtgttag                                      690


<210> 19
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:19 CDR 1 of variable domain of Heavy chain of I14

<400> 19
Gly Phe Thr Phe Thr Ser Ser Ala 
1               5               

<210> 20
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:20 CDR 2 of variable domain of Heavy chain of I14

<400> 20
Ile Val Val Gly Ser Gly Asn Thr 
1               5               

<210> 21
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:21 CDR 3 of variable domain of Heavy chain of I14

<400> 21
Cys Ala Ala Pro Tyr Cys Ser Ser Thr Thr Cys His Asp Gly Phe Asp 
1               5                   10                  15      
Ile Trp 
        

<210> 22
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:22 CDR 1 of variable domain of Light chain of I14

<400> 22
Gln Ser Val Ser Ser Ser Tyr 
1               5           

<210> 23
<400> 23
000

<210> 24
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:24 CDR 3 of variable domain of Light chain of I14

<400> 24
Cys Gln Gln Tyr Gly Arg Ser Pro Trp Thr Phe 
1               5                   10      

<210> 25
<211> 124
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:25 variable domain of Heavy chain of I14

<400> 25
Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr Ser 
1               5                   10                  15      
Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser Ala 
            20                  25                  30          
Met Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile Gly 
        35                  40                  45              
Trp Ile Val Val Gly Ser Gly Asn Thr Asp Tyr Val Gln Lys Phe Gln 
    50                  55                  60                  
Gly Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Pro Tyr Cys Ser Ser Thr Thr Cys His Asp Gly Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 

<210> 26
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:26 variable domain of Light chain of I14

<400> 26
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ala Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 27
<211> 472
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:27 Heavy chain of I14

<400> 27
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Thr Ser Ser Ala Met Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu 
    50                  55                  60                  
Glu Trp Ile Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asp Tyr Val 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Ala Pro Tyr Cys Ser Ser Thr Thr Cys His Asp Gly 
        115                 120                 125             
Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 28
<211> 233
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:28 Light chain of I14

<400> 28
Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly Val 
1               5                   10                  15      
His Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ala 
            20                  25                  30          
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        35                  40                  45              
Ser Ser Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  
Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg 
            100                 105                 110         
Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 29
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:29 I14_heavy_chain LeaderSequence

<400> 29
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 30
<211> 375
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:30 I14_heavy chain_Variable domain

<400> 30
caggtgcagc tggtgcagtc tgggcctgag gtgaagaagc ctgggacctc agtgaaggtc      60

tcctgcaagg cttctggatt cacctttact agctctgcta tgcagtgggt gcgacaggct     120

cgtggacaac gccttgagtg gataggatgg atcgtcgttg gcagtggtaa cacagactac     180

gtgcagaagt tccaaggaag agtcaccatt accagggaca tgtccacaag cacagcctac     240

atggagctga gcagcctgag atccgaggac acggccgtgt attactgtgc ggcaccatat     300

tgtagtagta ccacctgcca tgatggcttt gatatttggg gccaagggac aatggtcacc     360

gtctcttcag cctcc                                                      375


<210> 31
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:31 I14_heavy chain_Constant domain

<400> 31
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 32
<211> 1419
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:32 I14_heavy chain_Complete

<400> 32
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg gcctgaggtg aagaagcctg ggacctcagt gaaggtctcc     120

tgcaaggctt ctggattcac ctttactagc tctgctatgc agtgggtgcg acaggctcgt     180

ggacaacgcc ttgagtggat aggatggatc gtcgttggca gtggtaacac agactacgtg     240

cagaagttcc aaggaagagt caccattacc agggacatgt ccacaagcac agcctacatg     300

gagctgagca gcctgagatc cgaggacacg gccgtgtatt actgtgcggc accatattgt     360

agtagtacca cctgccatga tggctttgat atttggggcc aagggacaat ggtcaccgtc     420

tcttcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc     480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga acctgtgacg     540

gtctcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag     600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc     660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt     720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat    1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc    1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg    1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc    1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct    1260

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc    1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac    1380

tacacgcaga agagcctctc cctgtccccg ggtaaatga                           1419


<210> 33
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:33 I14 light chain LeaderSequence

<400> 33
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 34
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:34 I14_light_chain Variable Domain

<400> 34
gaaattgtga tgacgcagtc tccaggcacc ctgtctttgg ctccagggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc agcagctact taggctggta ccagcagaaa     120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca     180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag     240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta ggtcaccgtg gacgttcggc     300

caagggacca aggtggaaat caaacgaact                                      330


<210> 35
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:35 I14_light_chain ConstantRegion

<400> 35
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 36
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:36 I14_light_kappa_complete_seq

<400> 36
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgaa      60

attgtgatga cgcagtctcc aggcaccctg tctttggctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc agctacttag gctggtacca gcagaaacct     180

ggccaggctc ccaggctcct catctatggt gcatccagca gggccactgg catcccagac     240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct     300

gaagattttg cagtgtatta ctgtcagcag tatggtaggt caccgtggac gttcggccaa     360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 37
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:37 CDR 1 of variable domain of Heavy chain of F05

<400> 37
Gly Phe Thr Val Ser Ile Asn Tyr 
1               5               

<210> 38
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:38 CDR 2 of variable domain of Heavy chain of F05

<400> 38
Ile Tyr Ser Gly Gly Ser Thr 
1               5           

<210> 39
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:39 CDR 3 of variable domain of Heavy chain of F05

<400> 39
Cys Ala Ala Pro Leu Leu Trp Ala Asp Ser Tyr Tyr Met Asp Val Trp 
1               5                   10                  15      



<210> 40
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:40 CDR 1 of variable domain of Light chain of F05

<400> 40
Gln Asp Ile Arg Asn Asn 
1               5       

<210> 41
<400> 41
000

<210> 42
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:42 CDR 3 of variable domain of Light chain of F05

<400> 42
Cys Leu Gln His Asn Ser Tyr Leu Trp Thr Phe 
1               5                   10      

<210> 43
<211> 122
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:43 variable domain of Heavy chain of F05

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ile Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Pro Leu Leu Trp Ala Asp Ser Tyr Tyr Met Asp Val Trp Gly Lys 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120         

<210> 44
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:44 variable domain of Light chain of F05

<400> 44
Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asn 
            20                  25                  30          
Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Leu Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 45
<211> 469
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:45 Heavy chain of F05

<400> 45
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val 
        35                  40                  45              
Ser Ile Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Ala Pro Leu Leu Trp Ala Asp Ser Tyr Tyr Met Asp Val 
        115                 120                 125             
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 
Leu Ser Pro Gly Lys 
465                 

<210> 46
<211> 253
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:46 Light chain of F05

<400> 46
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              
Arg Asn Asn Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Arg Leu Ile Tyr Ala Ala Ser Thr Leu Gln Arg Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser 
            100                 105                 110         
Tyr Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys Asn Cys Leu Glu Ile Cys Ala 
225                 230                 235                 240 
Cys Ile Asp Ser Glu Gln Glu Asn Cys Glu Ser Phe Phe 
                245                 250             

<210> 47
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:47 F05_heavy_chain LeaderSequence

<400> 47
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 48
<211> 366
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:48 F05_heavy chain_Variable domain

<400> 48
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggatt caccgtcagt atcaactaca tgagttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca     180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt     240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcggc ccccttacta     300

tgggccgact cctactacat ggacgtctgg ggcaaaggga ccacggtcac cgtctcctca     360

gcctcc                                                                366


<210> 49
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:49 F05_heavy chain_Constant domain

<400> 49
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 50
<211> 1410
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:50 F05_heavy chain_Complete

<400> 50
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag      60

gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc     120

tgtgcagcct ctggattcac cgtcagtatc aactacatga gttgggtccg ccaggctcca     180

gggaaggggc tggagtgggt ctcagttatt tatagcggtg gtagcacata ctacgcagac     240

tccgtgaagg gcagattcac catctccaga gacaattcca agaacacgct gtatcttcaa     300

atgaacagcc tgagagccga ggacacggct gtgtattact gtgcggcccc cttactatgg     360

gccgactcct actacatgga cgtctggggc aaagggacca cggtcaccgt ctcctcagcc     420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aacctgtgac ggtctcgtgg     540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa     720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg     780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag     840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    1020

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa    1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg    1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc    1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg    1260

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag    1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag    1380

aagagcctct ccctgtcccc gggtaaatga                                     1410


<210> 51
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:51 F05 light chain LeaderSequence

<400> 51
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 52
<211> 327
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:52 F05_light_chain Variable Domain

<400> 52
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggcaagtca ggacattaga aataatttag gctggtttca gcagaaacca     120

gggaaagccc ctaagcgcct gatctatgct gcatccactt tacaacgtgg agtcccatca     180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtctacag cataatagtt acctttggac attcggccaa     300

gggaccaagg tggaaatcaa acgaact                                         327


<210> 53
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:53 F05_light_chain ConstantRegion

<400> 53
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 54
<211> 702
<212> DNA
<213> Homo sapiens


<220> 
<223> > SEQ ID NO:54 F05_light_kappa_complete_seq

<400> 54
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgcc      60

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc     120

acttgccggg caagtcagga cattagaaat aatttaggct ggtttcagca gaaaccaggg     180

aaagccccta agcgcctgat ctatgctgca tccactttac aacgtggagt cccatcaagg     240

ttcagcggca gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa     300

gattttgcaa cttattactg tctacagcat aatagttacc tttggacatt cggccaaggg     360

accaaggtgg aaatcaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct     420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc     480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag     540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg     600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                        702


<210> 55
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:55 CDR 1 of variable domain of Heavy chain of
      MAD0041G12

<400> 55
Gly Gly Thr Phe Ser Ser Tyr Thr 
1               5               

<210> 56
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:56 CDR 2 of variable domain of Heavy chain of
      MAD0041G12

<400> 56
Ile Ile Pro Met Leu Gly Ile Ala 
1               5               

<210> 57
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:57 CDR 3 of variable domain of Heavy chain of
      MAD0041G12

<400> 57
Cys Ala Arg Gly Ile Val Gly Ala Thr Pro Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15      



<210> 58
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:58 CDR 1 of variable domain of Light chain of
      MAD0041G12

<400> 58
Gln Ser Val Ser Ser Asn 
1               5       

<210> 59
<400> 59
000

<210> 60
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:60 CDR 3 of variable domain of Light chain of
      MAD0041G12

<400> 60
Cys Gln Gln Tyr Asn Asn Trp Leu Thr Phe 
1               5                   10  

<210> 61
<211> 123
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:61 variable domain of Heavy chain of MAD0041G12

<400> 61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Pro 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ile Pro Met Leu Gly Ile Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ile Val Gly Ala Thr Pro Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120             

<210> 62
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:62 variable domain of Light chain of MAD0041G12

<400> 62
Asp Ile Val Met Thr Gln Ser Pro Ala Ala Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Trp Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             

<210> 63
<211> 470
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:63 Heavy chain of MAD0041G12

<400> 63
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Pro Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              
Ser Ser Tyr Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Arg Ile Ile Pro Met Leu Gly Ile Ala Lys Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Ile Val Gly Ala Thr Pro Gly Tyr Phe Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 
Ser Leu Ser Pro Gly Lys 
465                 470 

<210> 64
<211> 232
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:64 Light chain of MAD0041G12

<400> 64
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ala Ala Leu Ser Val 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              
Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  
Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Trp Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Ser Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn 
            100                 105                 110         
Trp Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
        115                 120                 125             
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 
Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         

<210> 65
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:65 leader sequence of Heavy chain of MAD0041G12

<400> 65
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 66
<211> 369
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:66 variable domain of Heavy chain of MAD0041G12

<400> 66
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggccctc ggtgaaggtc      60

tcctgcaagg cttctggagg caccttcagc agctatacta tcaactgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tgcttggtat agcaaagtac     180

gcacagaagt ttcagggcag agtcacgatt accgcggaca aatccacgag cacagcctac     240

atggagttga gtagtctgag atctgaggac acggccgtct attactgtgc gagaggtata     300

gtgggagcta ctccggggta ctttgactac tggggccagg gaaccctggt caccgtctcc     360

tcagcttcc                                                             369


<210> 67
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:67 constant domain of Heavy chain of MAD0041G12

<400> 67
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 68
<211> 1413
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:68 complete sequence of Heavy chain of MAD0041G12

<400> 68
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg ggccctcggt gaaggtctcc     120

tgcaaggctt ctggaggcac cttcagcagc tatactatca actgggtgcg acaggcccct     180

ggacaagggc ttgagtggat gggaaggatc atccctatgc ttggtatagc aaagtacgca     240

cagaagtttc agggcagagt cacgattacc gcggacaaat ccacgagcac agcctacatg     300

gagttgagta gtctgagatc tgaggacacg gccgtctatt actgtgcgag aggtatagtg     360

ggagctactc cggggtactt tgactactgg ggccagggaa ccctggtcac cgtctcctca     420

gcttccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacctgt gacggtctcg     540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc     720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     960

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    1260

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg    1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    1380

cagaagagcc tctccctgtc cccgggtaaa tga                                 1413


<210> 69
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:69 leader sequence of Light chain of MAD0041G12

<400> 69
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 70
<211> 324
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:70 variable domain of Light chain of MAD0041G12

<400> 70
gacatcgtga tgacccagtc tccagccgcc ctgtctgtgt ctcccgggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct     120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc     180

aggttcagtg gcagttggtc tgggacagag ttcactctca ccatcagcag cctgcagtct     240

gaagatttag cagtttatta ctgtcagcag tataataact ggctcacttt cggcggaggg     300

accaaggtgg agatcaaacg aact                                            324


<210> 71
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:71 constant domain of Light chain of MAD0041G12

<400> 71
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 72
<211> 699
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:72 complete sequence of Light chain of MAD0041G12

<400> 72
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgac      60

atcgtgatga cccagtctcc agccgccctg tctgtgtctc ccggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc aacttagcct ggtaccagca gaaacctggc     180

caggctccca ggctcctcat ctatggtgca tccaccaggg ccactggtat cccagccagg     240

ttcagtggca gttggtctgg gacagagttc actctcacca tcagcagcct gcagtctgaa     300

gatttagcag tttattactg tcagcagtat aataactggc tcactttcgg cggagggacc     360

aaggtggaga tcaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat     420

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga     480

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt     540

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc     600

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc     660

tcgcccgtca caaagagctt caacagggga gagtgttag                            699


<210> 73
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:73 CDR 1 of variable domain of Heavy chain of
      MAD0041I21

<400> 73
Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               

<210> 74
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:74 CDR 2 of variable domain of Heavy chain of
      MAD0041I21

<400> 74
Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               

<210> 75
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:75 CDR 3 of variable domain of Heavy chain of
      MAD0041I21

<400> 75
Cys Ala Thr Gly Thr Tyr Asp Phe Trp Ser Asp Asn His Tyr Leu Asp 
1               5                   10                  15      
Tyr Trp 
        

<210> 76
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:76 CDR 1 of variable domain of Light chain of
      MAD0041I21

<400> 76
Gln Gly Ile Ser Ser Ser 
1               5       

<210> 77
<400> 77
000

<210> 78
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:78 CDR 3 of variable domain of Light chain of
      MAD0041I21

<400> 78
Cys Gln Gln Leu Asn Ser Tyr Pro Ser Thr Thr Phe 
1               5                   10          

<210> 79
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:79 variable domain of Heavy chain of MAD0041I21

<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Gly Thr Tyr Asp Phe Trp Ser Asp Asn His Tyr Leu Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125 

<210> 80
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:80 variable domain of Light chain of MAD0041I21

<400> 80
Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Ser 
                85                  90                  95      
Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 81
<211> 472
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:81 Heavy chain of MAD0041I21

<400> 81
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Ser Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Thr Gly Thr Tyr Asp Phe Trp Ser Asp Asn His Tyr 
        115                 120                 125             
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 82
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:82 Light chain of MAD0041I21

<400> 82
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              
Ser Ser Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser 
            100                 105                 110         
Tyr Pro Ser Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 83
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:83 leader sequence of Heavy chain of MAD0041I21

<400> 83
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 84
<211> 375
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:84 variable domain of Heavy chain of MAD0041I21

<400> 84
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct     120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatattat     180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtct     240

ctgcaaatga acagcctgag agctgcggac acggcagtgt attactgtgc gacgggtact     300

tacgattttt ggagtgacaa tcactacctt gactattggg gccagggaac cctggtcacc     360

gtctcctcag cttcc                                                      375


<210> 85
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:85 constant domain of Heavy chain of MAD0041I21

<400> 85
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 86
<211> 1419
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:86 complete sequence of Heavy chain of MAD0041I21

<400> 86
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag      60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc     120

tgtgcagcct ctggattcac cttcagtagc tatggcatgc actgggtccg ccaggctcca     180

ggcaaggggc tggagtgggt ggcagttata tcatatgatg gaagtaataa atattatgca     240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtctctg     300

caaatgaaca gcctgagagc tgcggacacg gcagtgtatt actgtgcgac gggtacttac     360

gatttttgga gtgacaatca ctaccttgac tattggggcc agggaaccct ggtcaccgtc     420

tcctcagctt ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc     480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga acctgtgacg     540

gtctcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag     600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc     660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt     720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat    1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc    1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg    1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc    1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct    1260

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc    1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac    1380

tacacgcaga agagcctctc cctgtccccg ggtaaatga                           1419


<210> 87
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:87 leader sequence of Light chain of MAD0041I21

<400> 87
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 88
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:88 variable domain of Light chain of MAD0041I21

<400> 88
gccatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattagc agttctttag cctggtatca gcaaaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca     180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtcaacag cttaatagtt acccttcgac cactttcggc     300

ggagggacca aggtggagat caaacgaact                                      330


<210> 89
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:89 constant domain of Light chain of MAD0041I21

<400> 89
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 90
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:90 complete sequence of Light chain of MAD0041I21

<400> 90
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgcc      60

atccagatga cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc     120

acttgccggg ccagtcaggg cattagcagt tctttagcct ggtatcagca aaaaccaggg     180

aaagccccta agctcctgat ctatgctgca tccactttgc aaagtggggt cccatcaagg     240

ttcagcggca gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa     300

gattttgcaa cttattactg tcaacagctt aatagttacc cttcgaccac tttcggcgga     360

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 91
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:91 CDR 1 of variable domain of Heavy chain of
      MAD0041K22

<400> 91
Gly Phe Thr Phe Ser Ala Tyr Gly 
1               5               

<210> 92
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:92 CDR 2 of variable domain of Heavy chain of
      MAD0041K22

<400> 92
Ile Ser Tyr Gly Gly Ser Asp Lys 
1               5               

<210> 93
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:93 CDR 3 of variable domain of Heavy chain of
      MAD0041K22

<400> 93
Cys Ala Lys Asp Gln Asp Asp Ala Tyr Tyr Phe Tyr Tyr Tyr Met Asp 
1               5                   10                  15      
Val Trp 
        

<210> 94
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:94 CDR 1 of variable domain of Light chain of
      MAD0041K22

<400> 94
Gln Ser Val Ser Ser Ser Tyr 
1               5           

<210> 95
<400> 95
000

<210> 96
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:96 CDR 3 of variable domain of Light chain of
      MAD0041K22

<400> 96
Cys Gln Gln Tyr Gly Gly Pro Leu Thr Phe 
1               5                   10  

<210> 97
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:97 variable domain of Heavy chain of MAD0041K22

<400> 97
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Gly Gly Ser Asp Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Gln Asp Asp Ala Tyr Tyr Phe Tyr Tyr Tyr Met Asp Val 
            100                 105                 110         
Trp Gly Lys Gly Thr Ala Val Thr Val Ser Ser Ala Ser 
        115                 120                 125 

<210> 98
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:98 variable domain of Light chain of MAD0041K22

<400> 98
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Val Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 99
<211> 472
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:99 Heavy chain of MAD0041K22

<400> 99
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ala Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ala Val Ile Ser Tyr Gly Gly Ser Asp Lys Tyr Tyr Val 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met 
            100                 105                 110         
Tyr Tyr Cys Ala Lys Asp Gln Asp Asp Ala Tyr Tyr Phe Tyr Tyr Tyr 
        115                 120                 125             
Met Asp Val Trp Gly Lys Gly Thr Ala Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 100
<211> 233
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:100 Light chain of MAD0041K22

<400> 100
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              
Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  
Arg Leu Leu Val Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Gly 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
            100                 105                 110         
Gly Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 101
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:101 leader sequence of Heavy chain of MAD0041K22

<400> 101
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 102
<211> 375
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:102 variable domain of Heavy chain of MAD0041K22

<400> 102
caggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      60

tcctgtgcag cctctggatt caccttcagt gcctatggca tgcactgggt ccgccaggct     120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg gtggaagtga taaatactat     180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agctgaggac acggctatgt attactgtgc gaaagaccag     300

gacgacgcct actacttcta ctactacatg gacgtctggg gcaaagggac cgcggtcacc     360

gtctcctcag cttcc                                                      375


<210> 103
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:103 constant domain of Heavy chain of MAD0041K22

<400> 103
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 104
<211> 1419
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:104 complete sequence of Heavy chain of MAD0041K22

<400> 104
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc     120

tgtgcagcct ctggattcac cttcagtgcc tatggcatgc actgggtccg ccaggctcca     180

ggcaaggggc tggagtgggt ggcagttata tcatatggtg gaagtgataa atactatgta     240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg     300

caaatgaaca gcctgagagc tgaggacacg gctatgtatt actgtgcgaa agaccaggac     360

gacgcctact acttctacta ctacatggac gtctggggca aagggaccgc ggtcaccgtc     420

tcctcagctt ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc     480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga acctgtgacg     540

gtctcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag     600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc     660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt     720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat    1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc    1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg    1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc    1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct    1260

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc    1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac    1380

tacacgcaga agagcctctc cctgtccccg ggtaaatga                           1419


<210> 105
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:105 leader sequence of Light chain of MAD0041K22

<400> 105
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 106
<211> 327
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:106 variable domain of Light chain of MAD0041K22

<400> 106
gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa     120

cctggccagg ctcccaggct cctcgtctat ggtgcatcca gcagggccac tggcatccca     180

ggcaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag     240

cctgaagatt ttgcagtgta ttactgtcag cagtatggtg gcccgctcac tttcggcgga     300

gggaccaagg tggagatcaa acgaact                                         327


<210> 107
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:107 constant domain of Light chain of MAD0041K22

<400> 107
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 108
<211> 702
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:108 complete sequence of Light chain of MAD0041K22

<400> 108
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgac      60

atcgtgatga cccagtctcc aggcaccctg tctttgtctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc agctacttag cctggtacca gcagaaacct     180

ggccaggctc ccaggctcct cgtctatggt gcatccagca gggccactgg catcccaggc     240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct     300

gaagattttg cagtgtatta ctgtcagcag tatggtggcc cgctcacttt cggcggaggg     360

accaaggtgg agatcaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct     420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc     480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag     540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg     600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                        702


<210> 109
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:109 CDR 1 of variable domain of Heavy chain of
      MAD0041M02

<400> 109
Gly Phe Thr Phe Ser Ser Tyr Val 
1               5               

<210> 110
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:110 CDR 2 of variable domain of Heavy chain of
      MAD0041M02

<400> 110
Ile Ser Tyr Gly Gly Ser Asn Lys 
1               5               

<210> 111
<211> 28
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:111 CDR 3 of variable domain of Heavy chain of
      MAD0041M02

<400> 111
Cys Ala Arg Asp Gly Gly Asp Ile Val Val Val Pro Gly Ala Ser Thr 
1               5                   10                  15      
Ser Glu Asn Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            20                  25              

<210> 112
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:112 CDR 1 of variable domain of Light chain of
      MAD0041M02

<400> 112
Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr 
1               5                   10          

<210> 113
<400> 113
000

<210> 114
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:114 CDR 3 of variable domain of Light chain of
      MAD0041M02

<400> 114
Cys Met Gln Arg Ile Glu Phe Pro Arg Thr Phe 
1               5                   10      

<210> 115
<211> 135
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:115 variable domain of Heavy chain of MAD0041M02

<400> 115
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Cys Tyr Cys 
                85                  90                  95      
Ala Arg Asp Gly Gly Asp Ile Val Val Val Pro Gly Ala Ser Thr Ser 
            100                 105                 110         
Glu Asn Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr 
        115                 120                 125             
Val Thr Val Ser Ser Ala Ser 
    130                 135 

<210> 116
<211> 115
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:116 variable domain of Light chain of MAD0041M02

<400> 116
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Asp Gly Asn Thr Tyr Leu Asp Trp Cys Leu Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      
Arg Ile Glu Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys Arg Thr 
        115 

<210> 117
<211> 482
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:117 Heavy chain of MAD0041M02

<400> 117
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ala Val Ile Ser Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Cys Tyr Cys Ala Arg Asp Gly Gly Asp Ile Val Val Val Pro Gly Ala 
        115                 120                 125             
Ser Thr Ser Glu Asn Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys 
    130                 135                 140                 
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
145                 150                 155                 160 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                165                 170                 175     
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            180                 185                 190         
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        195                 200                 205             
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    210                 215                 220                 
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
225                 230                 235                 240 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
                245                 250                 255     
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 
Gly Lys 
        

<210> 118
<211> 239
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:118 Light chain of MAD0041M02

<400> 118
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          
Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              
Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu Asp Trp Cys Leu Gln Lys 
    50                  55                  60                  
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala 
65                  70                  75                  80  
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         
Cys Met Gln Arg Ile Glu Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             
Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 
Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     
Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 

<210> 119
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:119 leader sequence of Heavy chain of MAD0041M02

<400> 119
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 120
<211> 405
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:120 variable domain of Heavy chain of MAD0041M02

<400> 120
caggtgcagc tgcaggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc      60

tcctgtgcag cctctggatt caccttcagt agctatgtta tgcactgggt ccgccaggct     120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg gtggaagcaa taaatactac     180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agctgaggac acggctgtgt gttactgtgc gagagatggc     300

ggggatattg tagtagtacc aggtgcttca acctcggaga actactacta ctactacatg     360

gacgtctggg gcaaagggac cacggtcacc gtctcctcag cctcc                     405


<210> 121
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:121 constant domain of Heavy chain of MAD0041M02

<400> 121
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 122
<211> 1449
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:122 complete sequence of Heavy chain of MAD0041M02

<400> 122
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgc aggagtcggg gggaggcgtg gtccagcctg ggaggtccct gagactctcc     120

tgtgcagcct ctggattcac cttcagtagc tatgttatgc actgggtccg ccaggctcca     180

ggcaaggggc tggagtgggt ggcagttata tcatatggtg gaagcaataa atactacgca     240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg     300

caaatgaaca gcctgagagc tgaggacacg gctgtgtgtt actgtgcgag agatggcggg     360

gatattgtag tagtaccagg tgcttcaacc tcggagaact actactacta ctacatggac     420

gtctggggca aagggaccac ggtcaccgtc tcctcagcct ccaccaaggg cccatcggtc     480

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg     540

gtcaaggact acttccccga acctgtgacg gtctcgtgga actcaggcgc cctgaccagc     600

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg     660

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag     720

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca     780

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     840

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     900

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     960

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc    1020

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac    1080

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa    1140

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg    1200

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg    1260

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc    1320

ctctatagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc    1380

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtccccg    1440

ggtaaatga                                                            1449


<210> 123
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:123 leader sequence of Light chain of MAD0041M02

<400> 123
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 124
<211> 345
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:124 variable domain of Light chain of MAD0041M02

<400> 124
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc      60

atctcctgca ggtctagtca gagcctcttg gatagtgatg atggaaacac ctatttggac     120

tggtgcctgc agaagccagg gcagtctcca cagctcctga tctatacgct ttcctatcgg     180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactaaaa     240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tatagagttt     300

cctaggacgt tcggccaagg gaccaaggtg gaaatcaaac gaact                     345


<210> 125
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:125 constant domain of Light chain of MAD0041M02

<400> 125
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 126
<211> 720
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:126 complete sequence of Light chain of MAD0041M02

<400> 126
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgat      60

attgtgatga cccagactcc actctccctg cccgtcaccc ctggagagcc ggcctccatc     120

tcctgcaggt ctagtcagag cctcttggat agtgatgatg gaaacaccta tttggactgg     180

tgcctgcaga agccagggca gtctccacag ctcctgatct atacgctttc ctatcgggcc     240

tctggagtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actaaaaatc     300

agcagggtgg aggctgagga tgttggagtt tattactgca tgcaacgtat agagtttcct     360

aggacgttcg gccaagggac caaggtggaa atcaaacgaa ctgtggctgc accatctgtc     420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa     540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa     660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag     720


<210> 127
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:127 CDR 1 of variable domain of Heavy chain of
      MAD0100F10

<400> 127
Gly Tyr Thr Leu Thr Glu Leu Ser 
1               5               

<210> 128
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:128 CDR 2 of variable domain of Heavy chain of
      MAD0100F10

<400> 128
Phe Asp Pro Ala Asp Ala Glu Thr 
1               5               

<210> 129
<211> 23
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:129 CDR 3 of variable domain of Heavy chain of
      MAD0100F10

<400> 129
Cys Ala Thr Ala Leu Pro Ile Thr Met Val Arg Gly Val Gln Tyr Tyr 
1               5                   10                  15      
Tyr Tyr Gly Met Asp Val Trp 
            20              

<210> 130
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:130 CDR 1 of variable domain of Light chain of
      MAD0100F10

<400> 130
Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      

<210> 131
<400> 131
000

<210> 132
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:132 CDR 3 of variable domain of Light chain of
      MAD0100F10

<400> 132
Cys Met Gln Val Thr Gln Phe Pro Tyr Thr Phe 
1               5                   10      

<210> 133
<211> 130
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:133 variable domain of Heavy chain of MAD0100F10

<400> 133
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Phe Asp Pro Ala Asp Ala Glu Thr Ile Tyr Ala Gln Lys Leu 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Ala Leu Pro Ile Thr Met Val Arg Gly Val Gln Tyr Tyr Tyr 
            100                 105                 110         
Tyr Gly Met Asp Val Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ser 
    130 

<210> 134
<211> 114
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:134 variable domain of Light chain of MAD0100F10

<400> 134
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Val 
                85                  90                  95      
Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr 
        

<210> 135
<211> 477
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:135 Heavy chain of MAD0100F10

<400> 135
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu 
        35                  40                  45              
Thr Glu Leu Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Gly Phe Asp Pro Ala Asp Ala Glu Thr Ile Tyr Ala 
65                  70                  75                  80  
Gln Lys Leu Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Thr Ala Leu Pro Ile Thr Met Val Arg Gly Val Gln 
        115                 120                 125             
Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Pro Gly Thr Thr Val Thr 
    130                 135                 140                 
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         

<210> 136
<211> 238
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:136 Light chain of MAD0100F10

<400> 136
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val 
            20                  25                  30          
Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              
Val His Ser Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro 
    50                  55                  60                  
Gly Gln Pro Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys 
            100                 105                 110         
Met Gln Val Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             

<210> 137
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:137 leader sequence of Heavy chain of MAD0100F10

<400> 137
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 138
<211> 390
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:138 variable domain of Heavy chain of MAD0100F10

<400> 138
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc      60

tcctgcaagg tttccggata cactctcact gaattatcca tgcactgggt gcgacagact     120

cctggaaaag gacttgagtg gatgggaggt tttgatcctg cagatgctga aacaatctac     180

gcacagaagt tgcagggcag agtcaccatg accgaggaca catctacaga cacagcctac     240

atggagctga gcagcctgag atctgaggac accgccgtat attactgtgc aacagccctg     300

cctattacta tggttcgggg agttcaatat tactactacg gtatggacgt ctggggccca     360

gggaccacgg tcaccgtctc ctcagcctcc                                      390


<210> 139
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:139 constant domain of Heavy chain of MAD0100F10

<400> 139
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 140
<211> 1434
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:140 complete sequence of Heavy chain of MAD0100F10

<400> 140
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc     120

tgcaaggttt ccggatacac tctcactgaa ttatccatgc actgggtgcg acagactcct     180

ggaaaaggac ttgagtggat gggaggtttt gatcctgcag atgctgaaac aatctacgca     240

cagaagttgc agggcagagt caccatgacc gaggacacat ctacagacac agcctacatg     300

gagctgagca gcctgagatc tgaggacacc gccgtatatt actgtgcaac agccctgcct     360

attactatgg ttcggggagt tcaatattac tactacggta tggacgtctg gggcccaggg     420

accacggtca ccgtctcctc agcctccacc aagggcccat cggtcttccc cctggcaccc     480

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc     540

cccgaacctg tgacggtctc gtggaactca ggcgccctga ccagcggcgt gcacaccttc     600

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc     660

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag     720

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca     780

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    1020

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc    1140

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa    1200

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac    1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc    1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag    1380

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggtaa atga          1434


<210> 141
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:141 leader sequence of Light chain of MAD0100F10

<400> 141
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 142
<211> 342
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:142 variable domain of Light chain of MAD0100F10

<400> 142
gatattgtga tgacccagac tccactctcc tcacctgtca cccttggaca gccggcctcc      60

atctcctgca ggtctagtca aagcctcgta cacagtgatg gaaacaccta cttgagttgg     120

cttcagcaga ggccaggcca gcctccaaga ctcctaattt ataagatttc taaccggttc     180

tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaagatc     240

agcagagtgg aagctgagga tgtcgggatt tattactgca tgcaagttac acaatttccg     300

tacacttttg gccaggggac caagctggag atcaaacgaa ct                        342


<210> 143
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:143 constant domain of Light chain of MAD0100F10

<400> 143
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 144
<211> 717
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:144 complete sequence of Light chain of MAD0100F10

<400> 144
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgat      60

attgtgatga cccagactcc actctcctca cctgtcaccc ttggacagcc ggcctccatc     120

tcctgcaggt ctagtcaaag cctcgtacac agtgatggaa acacctactt gagttggctt     180

cagcagaggc caggccagcc tccaagactc ctaatttata agatttctaa ccggttctct     240

ggggtcccag acagattcag tggcagtggg gcagggacag atttcacact gaagatcagc     300

agagtggaag ctgaggatgt cgggatttat tactgcatgc aagttacaca atttccgtac     360

acttttggcc aggggaccaa gctggagatc aaacgaactg tggctgcacc atctgtcttc     420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg     540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc     660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag        717


<210> 145
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:145 CDR 1 of variable domain of Heavy chain of
      MAD0100L19

<400> 145
Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               

<210> 146
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:146 CDR 2 of variable domain of Heavy chain of
      MAD0100L19

<400> 146
Ile Ser Ser Ser Gly Ser Asn Ile 
1               5               

<210> 147
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:147 CDR 3 of variable domain of Heavy chain of
      MAD0100L19

<400> 147
Cys Ala Arg Gly Arg Leu Trp Gly Trp Phe Asp Pro Trp 
1               5                   10              

<210> 148
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:148 CDR 1 of variable domain of Light chain of
      MAD0100L19

<400> 148
Gln Asp Ile Ser Asn Tyr 
1               5       

<210> 149
<400> 149
000

<210> 150
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:150 CDR 3 of variable domain of Light chain of
      MAD0100L19

<400> 150
Cys Gln Gln Tyr Asp His Leu Leu Ile Thr Phe 
1               5                   10      

<210> 151
<211> 120
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:151 variable domain of Heavy chain of MAD0100L19

<400> 151
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Phe Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Arg Leu Trp Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser 
        115                 120 

<210> 152
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:152 variable domain of Light chain of MAD0100L19

<400> 152
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp His Leu Leu Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 

<210> 153
<211> 467
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:153 Heavy chain of MAD0100L19

<400> 153
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Phe Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Asp Tyr Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ile Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Phe Cys Ala Arg Gly Arg Leu Trp Gly Trp Phe Asp Pro Trp Gly 
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 
Pro Gly Lys 
465         

<210> 154
<211> 233
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:154 Light chain of MAD0100L19

<400> 154
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile 
        35                  40                  45              
Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Tyr Asp Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp His 
            100                 105                 110         
Leu Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 155
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:155 leader sequence of Heavy chain of MAD0100L19

<400> 155
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 156
<211> 360
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:156 variable domain of Heavy chain of MAD0100L19

<400> 156
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ccggagggtc cctgagactt      60

ttctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct     120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtaa catatactat     180

gcagactctg tgaagggccg attcaccgtc tccagggaca acgccaagaa ctctctgtat     240

ctgcaaatga acagcctgag agccgaggac acggccgttt atttctgtgc gagaggaaga     300

ttgtgggggt ggttcgaccc ctggggccag ggaaccctgg tcaccgtctc ctcagcctcc     360


<210> 157
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:157 constant domain of Heavy chain of MAD0100L19

<400> 157
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 158
<211> 1404
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:158 complete sequence of Heavy chain of MAD0100L19

<400> 158
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag      60

gtgcagctgg tggagtctgg gggaggcttg gtcaagcccg gagggtccct gagacttttc     120

tgtgcagcct ctggattcac cttcagtgac tactacatga gctggttccg ccaggctcca     180

gggaaggggc tggagtgggt ttcatacatt agtagtagtg gtagtaacat atactatgca     240

gactctgtga agggccgatt caccgtctcc agggacaacg ccaagaactc tctgtatctg     300

caaatgaaca gcctgagagc cgaggacacg gccgtttatt tctgtgcgag aggaagattg     360

tgggggtggt tcgacccctg gggccaggga accctggtca ccgtctcctc agcctccacc     420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg     480

gccctgggct gcctggtcaa ggactacttc cccgaacctg tgacggtctc gtggaactca     540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac     600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc     660

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt     720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag    1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa    1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag    1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag    1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc    1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg    1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc    1380

ctctccctgt ccccgggtaa atga                                           1404


<210> 159
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:159 leader sequence of Light chain of MAD0100L19

<400> 159
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 160
<211> 327
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:160 variable domain of Light chain of MAD0100L19

<400> 160
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tgcaaacagg ggtcccatca     180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct     240

gaagatattg caacatatta ctgtcagcag tatgatcatc tcttgatcac cttcggccaa     300

gggacacgac tggagattaa acgaact                                         327


<210> 161
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:161 constant domain of Light chain of MAD0100L19

<400> 161
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 162
<211> 702
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:162 complete sequence of Light chain of MAD0100L19

<400> 162
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgac      60

atcgtgatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc     120

acttgccagg cgagtcagga cattagcaac tatttaaatt ggtatcagca gaaaccaggg     180

aaagccccta agctcctgat ctacgatgca tccaatttgc aaacaggggt cccatcaagg     240

ttcagtggaa gtggatctgg gacagatttt actttcacca tcagcagcct gcagcctgaa     300

gatattgcaa catattactg tcagcagtat gatcatctct tgatcacctt cggccaaggg     360

acacgactgg agattaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct     420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc     480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag     540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg     600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                        702


<210> 163
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:163 CDR 1 of variable domain of Heavy chain of
      MAD0101H20

<400> 163
Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 164
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:164 CDR 2 of variable domain of Heavy chain of
      MAD0101H20

<400> 164
Ile Thr Pro Ile Phe His Thr Ala 
1               5               

<210> 165
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:165 CDR 3 of variable domain of Heavy chain of
      MAD0101H20

<400> 165
Cys Ala Arg Glu Thr Gly Asp Gln Gly Val Thr Ala Pro Phe Asp Leu 
1               5                   10                  15      
Trp 
    

<210> 166
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:166 CDR 1 of variable domain of Light chain of
      MAD0101H20

<400> 166
Gln Ser Val Ser Ser Tyr 
1               5       

<210> 167
<400> 167
000

<210> 168
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:168 CDR 3 of variable domain of Light chain of
      MAD0101H20

<400> 168
Cys Gln Leu Arg Gly Asn Trp Pro Pro Trp Thr Phe 
1               5                   10          

<210> 169
<211> 124
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:169 variable domain of Heavy chain of MAD0101H20

<400> 169
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Thr Pro Ile Phe His Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Thr Gly Asp Gln Gly Val Thr Ala Pro Phe Asp Leu Trp 
            100                 105                 110         
Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 

<210> 170
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:170 variable domain of Light chain of MAD0101H20

<400> 170
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Arg Gly Asn Trp Pro Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 171
<211> 471
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:171 Heavy chain of MAD0101H20

<400> 171
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Gly Ile Thr Pro Ile Phe His Thr Ala Asn Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Glu Thr Gly Asp Gln Gly Val Thr Ala Pro Phe 
        115                 120                 125             
Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 
Leu Ser Leu Ser Pro Gly Lys 
465                 470     

<210> 172
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:172 Light chain of MAD0101H20

<400> 172
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              
Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  
Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Arg Gly Asn 
            100                 105                 110         
Trp Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 173
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:173 leader sequence of Heavy chain of MAD0101H20

<400> 173
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 174
<211> 372
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:174 variable domain of Heavy chain of MAD0101H20

<400> 174
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc      60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggaggg atcaccccta tctttcacac agcaaactac     180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagtctac     240

atggagctga gcagcctgag ctctgaggac acggccgtct attactgtgc gagggagacc     300

ggcgaccagg gagttacagc ccctttcgat ctctggggcc gtggcaccct ggtcactgtc     360

tcctcagcct cc                                                         372


<210> 175
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:175 constant domain of Heavy chain of MAD0101H20

<400> 175
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 176
<211> 1416
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:176 complete sequence of Heavy chain of MAD0101H20

<400> 176
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc     120

tgcaaggctt ctggaggcac cttcagcagc tatgctatca gctgggtgcg acaggcccct     180

ggacaagggc ttgagtggat gggagggatc acccctatct ttcacacagc aaactacgca     240

cagaagttcc agggcagagt cacgattacc gcggacgaat ccacgagcac agtctacatg     300

gagctgagca gcctgagctc tgaggacacg gccgtctatt actgtgcgag ggagaccggc     360

gaccagggag ttacagcccc tttcgatctc tggggccgtg gcaccctggt cactgtctcc     420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc tgtgacggtc     540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag     720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc    1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc    1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag    1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac    1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc    1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg    1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac    1380

acgcagaaga gcctctccct gtccccgggt aaatga                              1416


<210> 177
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:177 leader sequence of Light chain of MAD0101H20

<400> 177
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 178
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:178 variable domain of Light chain of MAD0101H20

<400> 178
gaaattgtga tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct     120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc     180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct     240

gaagattttg cagtttatta ctgtcagctg cgtggcaact ggcctccgtg gacgttcggc     300

caagggacca aggtggaaat caaacgaact                                      330


<210> 179
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:179 constant domain of Light chain of MAD0101H20

<400> 179
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 180
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:180 complete sequence of Light chain of MAD0101H20

<400> 180
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgaa      60

attgtgatga cgcagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc     180

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg     240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa     300

gattttgcag tttattactg tcagctgcgt ggcaactggc ctccgtggac gttcggccaa     360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 181
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:181 CDR 1 of variable domain of Heavy chain of
      MAD0102F20

<400> 181
Gly Tyr Ser Leu Ile Glu Leu Ser 
1               5               

<210> 182
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:182 CDR 2 of variable domain of Heavy chain of
      MAD0102F20

<400> 182
Phe Asp Pro Glu Asp Val Glu Thr 
1               5               

<210> 183
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:183 CDR 3 of variable domain of Heavy chain of
      MAD0102F20

<400> 183
Cys Ala Thr Phe Phe Ala Val Arg Gly Ala Leu Asn Trp Phe Asp Ser 
1               5                   10                  15      
Trp 
    

<210> 184
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:184 CDR 1 of variable domain of Light chain of
      MAD0102F20

<400> 184
Gln Ser Val Ser Ser Asn 
1               5       

<210> 185
<400> 185
000

<210> 186
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:186 CDR 3 of variable domain of Light chain of
      MAD0102F20

<400> 186
Cys Gln Gln Tyr Asn Asn Trp Pro Pro Leu Thr Phe 
1               5                   10          

<210> 187
<211> 124
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:187 variable domain of Heavy chain of MAD0102F20

<400> 187
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ser Leu Ile Glu Leu 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Phe Asp Pro Glu Asp Val Glu Thr Ile Tyr Ala Gln Asn Leu 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Phe Phe Ala Val Arg Gly Ala Leu Asn Trp Phe Asp Ser Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 

<210> 188
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:188 variable domain of Light chain of MAD0102F20

<400> 188
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Leu Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      
Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 189
<211> 471
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:189 Heavy chain of MAD0102F20

<400> 189
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ser Leu 
        35                  40                  45              
Ile Glu Leu Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Gly Phe Asp Pro Glu Asp Val Glu Thr Ile Tyr Ala 
65                  70                  75                  80  
Gln Asn Leu Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Thr Phe Phe Ala Val Arg Gly Ala Leu Asn Trp Phe 
        115                 120                 125             
Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 
Leu Ser Leu Ser Pro Gly Lys 
465                 470     

<210> 190
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:190 Light chain of MAD0102F20

<400> 190
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              
Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  
Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Leu Pro Ala Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn 
            100                 105                 110         
Trp Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 191
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:191 leader sequence of Heavy chain of MAD0102F20

<400> 191
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 192
<211> 372
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:192 variable domain of Heavy chain of MAD0102F20

<400> 192
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc      60

tcctgcaagg tttccggata cagcctcatt gaattatcca tgcactgggt gcgacaggct     120

cctggaaaag ggcttgagtg gatgggaggg tttgatcctg aagatgttga aacaatctac     180

gcacagaacc tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac     240

atggagctaa gcagcctgag atctgaggac acggccgtgt attactgtgc aacttttttt     300

gcggttcggg gagctctgaa ctggttcgac tcctggggcc agggaaccct ggtcaccgtc     360

tcctcagcct cc                                                         372


<210> 193
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:193 constant domain of Heavy chain of MAD0102F20

<400> 193
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 194
<211> 1416
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:194 complete sequence of Heavy chain of MAD0102F20

<400> 194
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc     120

tgcaaggttt ccggatacag cctcattgaa ttatccatgc actgggtgcg acaggctcct     180

ggaaaagggc ttgagtggat gggagggttt gatcctgaag atgttgaaac aatctacgca     240

cagaacctcc agggcagagt caccatgacc gaggacacat ctacagacac agcctacatg     300

gagctaagca gcctgagatc tgaggacacg gccgtgtatt actgtgcaac tttttttgcg     360

gttcggggag ctctgaactg gttcgactcc tggggccagg gaaccctggt caccgtctcc     420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc tgtgacggtc     540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag     720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc    1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc    1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag    1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac    1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc    1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg    1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac    1380

acgcagaaga gcctctccct gtccccgggt aaatga                              1416


<210> 195
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:195 leader sequence of Light chain of MAD0102F20

<400> 195
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 196
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:196 variable domain of Light chain of MAD0102F20

<400> 196
gaaattgtgt tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct     120

ggccaggctc ccaggctcct catctatggt gcatcaacca gggccactgg tctcccagcc     180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct     240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccgct cacttttggc     300

caggggacca agctcgagat caaacgaact                                      330


<210> 197
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:197 constant domain of Light chain of MAD0102F20

<400> 197
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 198
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:198 complete sequence of Light chain of MAD0102F20

<400> 198
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgaa      60

attgtgttga cacagtctcc agccaccctg tctgtgtctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc aacttagcct ggtaccagca gaaacctggc     180

caggctccca ggctcctcat ctatggtgca tcaaccaggg ccactggtct cccagccagg     240

ttcagtggca gtgggtctgg gacagagttc actctcacca tcagcagcct gcagtctgaa     300

gattttgcag tttattactg tcagcagtat aataactggc ctccgctcac ttttggccag     360

gggaccaagc tcgagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 199
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:199 CDR 1 of variable domain of Heavy chain of
      MAD0102F22

<400> 199
Gly Gly Ser Ile Ser Asn Asn Tyr 
1               5               

<210> 200
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:200 CDR 2 of variable domain of Heavy chain of
      MAD0102F22

<400> 200
Ile Phe Tyr Ser Gly Ser Thr 
1               5           

<210> 201
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:201 CDR 3 of variable domain of Heavy chain of
      MAD0102F22

<400> 201
Cys Ala Arg Gly Ser Gly Trp Tyr Leu Tyr Trp Tyr Phe Asp Leu Trp 
1               5                   10                  15      



<210> 202
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:202 CDR 1 of variable domain of Light chain of
      MAD0102F22

<400> 202
Gln Ser Ile Ser Ser Ser Tyr 
1               5           

<210> 203
<400> 203
000

<210> 204
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:204 CDR 3 of variable domain of Light chain of
      MAD0102F22

<400> 204
Cys Gln Gln Tyr Gly Ser Ser Pro Gln Thr Phe 
1               5                   10      

<210> 205
<211> 122
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:205 variable domain of Heavy chain of MAD0102F22

<400> 205
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Asn 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly His Ile Phe Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Ser Gly Trp Tyr Leu Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120         

<210> 206
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:206 variable domain of Light chain of MAD0102F22

<400> 206
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Leu Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 207
<211> 469
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:207 Heavy chain of MAD0102F22

<400> 207
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              
Ser Asn Asn Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly His Ile Phe Tyr Ser Gly Ser Thr Asn Tyr Asn Pro 
65                  70                  75                  80  
Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      
Phe Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Gly Ser Gly Trp Tyr Leu Tyr Trp Tyr Phe Asp Leu 
        115                 120                 125             
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 
Leu Ser Pro Gly Lys 
465                 

<210> 208
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:208 Light chain of MAD0102F22

<400> 208
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              
Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  
Arg Leu Leu Leu Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
            100                 105                 110         
Ser Ser Pro Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 209
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:209 leader sequence of Heavy chain of MAD0102F22

<400> 209
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 210
<211> 366
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:210 variable domain of Heavy chain of MAD0102F22

<400> 210
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc      60

acttgcactg tctctggtgg ctccatcagt aataactact ggagttggat ccggcagccc     120

ccagggaagg gactggagtg gattgggcat atcttttaca gtgggagcac caactacaac     180

ccctccctca agagtcgagt caccatctca gtagacacgt ccaagaatca gttctccctg     240

aagctgaggt ctgtgaccgc tgcggacacg gccgtctatt actgtgcgag agggagtggc     300

tggtacctat actggtactt cgatctctgg ggccgtggca ccctggtcac tgtctcctca     360

gcttcc                                                                366


<210> 211
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:211 constant domain of Heavy chain of MAD0102F22

<400> 211
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 212
<211> 1410
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:212 complete sequence of Heavy chain of MAD0102F22

<400> 212
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcact     120

tgcactgtct ctggtggctc catcagtaat aactactgga gttggatccg gcagccccca     180

gggaagggac tggagtggat tgggcatatc ttttacagtg ggagcaccaa ctacaacccc     240

tccctcaaga gtcgagtcac catctcagta gacacgtcca agaatcagtt ctccctgaag     300

ctgaggtctg tgaccgctgc ggacacggcc gtctattact gtgcgagagg gagtggctgg     360

tacctatact ggtacttcga tctctggggc cgtggcaccc tggtcactgt ctcctcagct     420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aacctgtgac ggtctcgtgg     540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa     720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg     780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag     840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    1020

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa    1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg    1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc    1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg    1260

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag    1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag    1380

aagagcctct ccctgtcccc gggtaaatga                                     1410


<210> 213
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:213 leader sequence of Light chain of MAD0102F22

<400> 213
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 214
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:214 variable domain of Light chain of MAD0102F22

<400> 214
gaaattgtga tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      60

ctctcctgca gggccagtca gagtattagc agcagctact tagcctggta ccagcagaaa     120

cctggccagg ctcccaggct cctcctctat ggtgcatcca gcagggccac tggcatccca     180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag     240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctca aacttttggc     300

caggggacca agctggagat caaacgaact                                      330


<210> 215
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:215 constant domain of Light chain of MAD0102F22

<400> 215
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 216
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:216 complete sequence of Light chain of MAD0102F22

<400> 216
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgaa      60

attgtgatga cgcagtctcc aggcaccctg tctttgtctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tattagcagc agctacttag cctggtacca gcagaaacct     180

ggccaggctc ccaggctcct cctctatggt gcatccagca gggccactgg catcccagac     240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct     300

gaagattttg cagtgtatta ctgtcagcag tatggtagct cacctcaaac ttttggccag     360

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 217
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:217 CDR 1 of variable domain of Heavy chain of
      MAD0102G04

<400> 217
Gly Gly Thr Phe Ser Asn Phe Ala 
1               5               

<210> 218
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:218 CDR 2 of variable domain of Heavy chain of
      MAD0102G04

<400> 218
Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               

<210> 219
<211> 14
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:219 CDR 3 of variable domain of Heavy chain of
      MAD0102G04

<400> 219
Cys Arg Ala Asp Ile Ala Leu Gln Trp Ala Ser Asp Ile Trp 
1               5                   10                  

<210> 220
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:220 CDR 1 of variable domain of Light chain of
      MAD0102G04

<400> 220
Gln Ser Val Ser Ser Tyr 
1               5       

<210> 221
<400> 221
000

<210> 222
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO: 222 CDR 3 of variable domain of Light chain of
      MAD0102G04

<400> 222
Cys Gln Gln Arg Ser Asn Trp Pro Pro Leu Ile Thr Phe 
1               5                   10              

<210> 223
<211> 121
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:223 variable domain of Heavy chain of MAD0102G04

<400> 223
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Phe 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Ile Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Arg Ala Asp Ile Ala Leu Gln Trp Ala Ser Asp Ile Trp Gly Gln Gly 
            100                 105                 110         
Thr Met Val Ser Val Ser Ser Ala Ser 
        115                 120     

<210> 224
<211> 111
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:224 variable domain of Light chain of MAD0102G04

<400> 224
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      
Leu Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105                 110     

<210> 225
<211> 468
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:225 Heavy chain of MAD0102G04

<400> 225
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              
Ser Asn Phe Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Leu Ile Ala Asp Glu Ser Thr Arg 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Arg Ala Asp Ile Ala Leu Gln Trp Ala Ser Asp Ile Trp 
        115                 120                 125             
Gly Gln Gly Thr Met Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 226
<211> 235
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:226 Light chain of MAD0102G04

<400> 226
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              
Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  
Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
            100                 105                 110         
Trp Pro Pro Leu Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 

<210> 227
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:227 leader sequence of Heavy chain of MAD0102G04

<400> 227
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 228
<211> 363
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:228 variable domain of Heavy chain of MAD0102G04

<400> 228
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc      60

tcctgcaagg cttctggagg caccttcagc aactttgcta tcagctgggt gcgacaggcc     120

cctggacagg gacttgagtg gatgggaggg atcatcccta tctttggaac agcaaactac     180

gcacagaagt tccagggcag agtcacgctt atcgcggacg aatccacgag gacagcctac     240

atggaactga gcagcctgac atctgaggac acggccgtgt attactgccg ggccgatatt     300

gcactacaat gggcttctga tatctggggc caagggacaa tggtcagcgt ctcttcggct     360

tcc                                                                   363


<210> 229
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:229 constant domain of Heavy chain of MAD0102G04

<400> 229
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 230
<211> 1407
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:230 complete sequence of Heavy chain of MAD0102G04

<400> 230
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc     120

tgcaaggctt ctggaggcac cttcagcaac tttgctatca gctgggtgcg acaggcccct     180

ggacagggac ttgagtggat gggagggatc atccctatct ttggaacagc aaactacgca     240

cagaagttcc agggcagagt cacgcttatc gcggacgaat ccacgaggac agcctacatg     300

gaactgagca gcctgacatc tgaggacacg gccgtgtatt actgccgggc cgatattgca     360

ctacaatggg cttctgatat ctggggccaa gggacaatgg tcagcgtctc ttcggcttcc     420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     480

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac    1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc    1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc    1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg    1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac    1260

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag    1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag    1380

agcctctccc tgtccccggg taaatga                                        1407


<210> 231
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:231 leader sequence of Light chain of MAD0102G04

<400> 231
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 232
<211> 333
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:232 variable domain of Light chain of MAD0102G04

<400> 232
gaaattgtga tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct     120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc     180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct     240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccctt aatcactttc     300

ggccctggga ccaaagtgga tatcaaacga act                                  333


<210> 233
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:233 constant domain of Light chain of MAD0102G04

<400> 233
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 234
<211> 708
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:234 complete sequence of Light chain of MAD0102G04

<400> 234
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgaa      60

attgtgatga cgcagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc     180

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg     240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa     300

gattttgcag tttattactg tcagcagcgt agcaactggc ctcccttaat cactttcggc     360

cctgggacca aagtggatat caaacgaact gtggctgcac catctgtctt catcttcccg     420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc     480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc     540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg     600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag     660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                  708


<210> 235
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:235 CDR 1 of variable domain of Heavy chain of
      MAD0008C14

<400> 235
Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               

<210> 236
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:236 CDR 2 of variable domain of Heavy chain of
      MAD0008C14

<400> 236
Ile Tyr Ser Gly Gly Ser Thr 
1               5           

<210> 237
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:237 CDR 3 of variable domain of Heavy chain of
      MAD0008C14

<400> 237
Cys Val Arg Asp Tyr Ser Tyr Gly Met Asp Val Trp 
1               5                   10          

<210> 238
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:238 CDR 1 of variable domain of Light chain of
      MAD0008C14

<400> 238
Gln Gly Ile Ser Ser Tyr 
1               5       

<210> 239
<400> 239
000

<210> 240
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:240 CDR 3 of variable domain of Light chain of
      MAD0008C14

<400> 240
Cys Gln Gln Val Asn Ser Tyr Pro Thr Phe 
1               5                   10  

<210> 241
<211> 119
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:241 variable domain of Heavy chain of MAD0008C14

<400> 241
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      
Arg Asp Leu Tyr Ser Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser 
        115                 

<210> 242
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:242 variable domain of Light chain of MAD0008C14

<400> 242
Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105             

<210> 243
<211> 466
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:243 Heavy chain of MAD0008C14

<400> 243
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val 
        35                  40                  45              
Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp 
65                  70                  75                  80  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Val Arg Asp Leu Tyr Ser Tyr Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 
Gly Lys 
465     

<210> 244
<211> 232
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:244 Light chain of MAD0008C14

<400> 244
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              
Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser 
            100                 105                 110         
Tyr Pro Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 
Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         

<210> 245
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:245 leader sequence of Heavy chain of MAD0008C14

<400> 245
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 246
<211> 357
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:246 variable domain of Heavy chain of MAD0008C14

<400> 246
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggact caccgtcagt agcaactaca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca     180

gactccgtga aggacagatt caccatctcc agagacaatt ccaagaacac gctgtatctt     240

caaatgaaca gcctgagagc cgaggacacg gctgtatatt actgtgtgag agatctctac     300

tcctacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc agcctcc        357


<210> 247
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:247 constant domain of Heavy chain of MAD0008C14

<400> 247
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 248
<211> 1401
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:248 complete sequence of Heavy chain of MAD0008C14

<400> 248
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag      60

gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc     120

tgtgcagcct ctggactcac cgtcagtagc aactacatga gctgggtccg ccaggctcca     180

gggaaggggc tggagtgggt ctcagttatt tatagcggtg gtagcacatt ctacgcagac     240

tccgtgaagg acagattcac catctccaga gacaattcca agaacacgct gtatcttcaa     300

atgaacagcc tgagagccga ggacacggct gtatattact gtgtgagaga tctctactcc     360

tacggtatgg acgtctgggg ccaagggacc acggtcaccg tctcctcagc ctccaccaag     420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     480

ctgggctgcc tggtcaagga ctacttcccc gaacctgtga cggtctcgtg gaactcaggc     540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     660

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac     720

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg    1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac    1140

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg    1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac    1260

ggctccttct tcctctatag caagctcacc gtggacaaga gcaggtggca gcaggggaac    1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc    1380

tccctgtccc cgggtaaatg a                                              1401


<210> 249
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:249 leader sequence of Light chain of MAD0008C14

<400> 249
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 250
<211> 324
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:250 variable domain of Light chain of MAD0008C14

<400> 250
gccatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccctca     180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtcaacag gttaatagtt accccacctt cggccaaggg     300

acacgactgg agattaaacg aact                                            324


<210> 251
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:251 constant domain of Light chain of MAD0008C14

<400> 251
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 252
<211> 699
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:252 complete sequence of Light chain of MAD0008C14

<400> 252
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgcc      60

atccagatga cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc     120

acttgccggg ccagtcaggg cattagcagt tatttagcct ggtatcagca aaaaccaggg     180

aaagccccta agctcctgat ctatgctgca tccactttgc aaagtggggt cccctcaagg     240

ttcagcggca gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa     300

gattttgcaa cttattactg tcaacaggtt aatagttacc ccaccttcgg ccaagggaca     360

cgactggaga ttaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat     420

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga     480

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt     540

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc     600

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc     660

tcgcccgtca caaagagctt caacagggga gagtgttag                            699


<210> 253
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:253 CDR 1 of variable domain of Heavy chain of
      MAD0008D14

<400> 253
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 254
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:254 CDR 2 of variable domain of Heavy chain of
      MAD0008D14

<400> 254
Ile Ser Phe Asp Gly Ser Lys Lys 
1               5               

<210> 255
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:255 CDR 3 of variable domain of Heavy chain of
      MAD0008D14

<400> 255
Cys Ala Arg Glu Gly Gln Trp Leu Asn Trp Ala Phe Asp Tyr Trp 
1               5                   10                  15  

<210> 256
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:256 CDR 1 of variable domain of Light chain of
      MAD0008D14

<400> 256
Gln Ser Ile Ser Ser Tyr 
1               5       

<210> 257
<400> 257
000

<210> 258
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:258 CDR 3 of variable domain of Light chain of
      MAD0008D14

<400> 258
Cys Gln Gln Ser Tyr Ser Thr Pro Thr Trp Thr Phe 
1               5                   10          

<210> 259
<211> 122
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:259 variable domain of Heavy chain of MAD0008D14

<400> 259
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Phe Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Gln Trp Leu Asn Trp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120         

<210> 260
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:260 variable domain of Light chain of MAD0008D14

<400> 260
Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Leu Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Thr 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 261
<211> 469
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:261 Heavy chain of MAD0008D14

<400> 261
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          
Pro Gly Lys Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ala Val Ile Ser Phe Asp Gly Ser Lys Lys Tyr Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Glu Gly Gln Trp Leu Asn Trp Ala Phe Asp Tyr 
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 
Leu Ser Pro Gly Lys 
465                 

<210> 262
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:262 Light chain of MAD0008D14

<400> 262
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Ser Ile 
        35                  40                  45              
Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Tyr Leu Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
            100                 105                 110         
Thr Pro Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 263
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:263 leader sequence of Heavy chain of MAD0008D14

<400> 263
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 264
<211> 366
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:264 variable domain of Heavy chain of MAD0008D14

<400> 264
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc cagggaagtc cctgagactc      60

tcctgtgcag actctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct     120

ccaggcaagg ggctggagtg ggtggcagtt atatcatttg atggaagtaa gaaatactac     180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtac     240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagagggg     300

cagtggctaa attgggcctt tgactactgg ggccagggaa ccctggtcac cgtctcctca     360

gcctcc                                                                366


<210> 265
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:265 constant domain of Heavy chain of MAD0008D14

<400> 265
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 266
<211> 1410
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:266 complete sequence of Heavy chain of MAD0008D14

<400> 266
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag      60

gtgcagctgg tggagtctgg gggaggcgtg gtccagccag ggaagtccct gagactctcc     120

tgtgcagact ctggattcac cttcagtagc tatgctatgc actgggtccg ccaggctcca     180

ggcaaggggc tggagtgggt ggcagttata tcatttgatg gaagtaagaa atactacgca     240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtacctg     300

caaatgaaca gcctgagagc tgaggacacg gctgtgtatt actgtgcgag agaggggcag     360

tggctaaatt gggcctttga ctactggggc cagggaaccc tggtcaccgt ctcctcagcc     420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aacctgtgac ggtctcgtgg     540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa     720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg     780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag     840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    1020

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa    1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg    1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc    1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg    1260

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag    1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag    1380

aagagcctct ccctgtcccc gggtaaatga                                     1410


<210> 267
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:267 leader sequence of Light chain of MAD0008D14

<400> 267
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 268
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:268 variable domain of Light chain of MAD0008D14

<400> 268
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggcaggtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatctt gcatccactt tgcaaagtgg ggtcccatca     180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttacta ctgtcaacag agttacagta cccccacgtg gacgttcggc     300

caagggacca aggtggaaat caaacgaact                                      330


<210> 269
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:269 constant domain of Light chain of MAD0008D14

<400> 269
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 270
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:270 complete sequence of Light chain of MAD0008D14

<400> 270
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgcc      60

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc     120

acttgccggg caggtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg     180

aaagccccta agctcctgat ctatcttgca tccactttgc aaagtggggt cccatcaagg     240

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa     300

gattttgcaa cttactactg tcaacagagt tacagtaccc ccacgtggac gttcggccaa     360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 271
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:271 CDR 1 of variable domain of Heavy chain of
      MAD0008B07

<400> 271
Gly Phe Thr Phe Thr Asn Tyr Tyr 
1               5               

<210> 272
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:272 CDR 2 of variable domain of Heavy chain of
      MAD0008B07

<400> 272
Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               

<210> 273
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:273 CDR 3 of variable domain of Heavy chain of
      MAD0008B07

<400> 273
Cys Ala Asp Leu Leu Leu Asp Tyr Trp 
1               5                   

<210> 274
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:274 CDR 1 of variable domain of Light chain of
      MAD0008B07

<400> 274
Gln Gly Ile Asn Asn Tyr 
1               5       

<210> 275
<400> 275
000

<210> 276
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:276 CDR 3 of variable domain of Light chain of
      MAD0008B07

<400> 276
Cys Gln Gln Tyr Asn Ser Tyr Pro Phe Thr Phe 
1               5                   10      

<210> 277
<211> 116
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:277 variable domain of Heavy chain of MAD0008B07

<400> 277
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Arg Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Asp Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Ala Ser 
        115     

<210> 278
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:278 variable domain of Light chain of MAD0008B07

<400> 278
Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 

<210> 279
<211> 463
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:279 Heavy chain of MAD0008B07

<400> 279
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Thr Asn Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ile Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Arg 
                85                  90                  95      
Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Asp Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             

<210> 280
<211> 233
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:280 Light chain of MAD0008B07

<400> 280
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              
Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         
Tyr Pro Phe Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 281
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:281 leader sequence of Heavy chain of MAD0008B07

<400> 281
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 282
<211> 348
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:282 variable domain of Heavy chain of MAD0008B07

<400> 282
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      60

tcctgcaaag catctggatt caccttcacc aactactata ttcactgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaatctac     180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgcg cacagtctac     240

atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc ggatctactc     300

ctggactact ggggccaggg aaccctggtc accgtctcct cagcttcc                  348


<210> 283
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:283 constant domain of Heavy chain of MAD0008B07

<400> 283
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 284
<211> 1392
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:284 complete sequence of Heavy chain of MAD0008B07

<400> 284
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtttcc     120

tgcaaagcat ctggattcac cttcaccaac tactatattc actgggtgcg acaggcccct     180

ggacaagggc ttgagtggat gggaataatc aaccctagtg gtggtagcac aatctacgca     240

cagaagttcc agggcagagt caccatgacc agggacacgt ccacgcgcac agtctacatg     300

gaactgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgga tctactcctg     360

gactactggg gccagggaac cctggtcacc gtctcctcag cttccaccaa gggcccatcg     420

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     480

ctggtcaagg actacttccc cgaacctgtg acggtctcgt ggaactcagg cgccctgacc     540

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     600

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     660

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac     720

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     840

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     900

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     960

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc    1020

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc    1140

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    1200

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc    1260

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca    1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtcc    1380

ccgggtaaat ga                                                        1392


<210> 285
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:285 leader sequence of Light chain of MAD0008B07

<400> 285
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggggt acattcc        57


<210> 286
<211> 327
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:286 variable domain of Light chain of MAD0008B07

<400> 286
gccatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgtc gggcgagtca gggcattaac aattatttag cctggtttca gcagaaacca     120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct     240

gaagattttg caacttatta ctgccaacaa tataatagtt accccttcac cttcggccaa     300

gggacacgac tggagattaa acgaact                                         327


<210> 287
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:287 constant domain of Light chain of MAD0008B07

<400> 287
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 288
<211> 702
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:288 complete sequence of Light chain of MAD0008B07

<400> 288
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggggt acattccgcc      60

atccagatga cccagtctcc atcctcactg tctgcatctg taggagacag agtcaccatc     120

acttgtcggg cgagtcaggg cattaacaat tatttagcct ggtttcagca gaaaccaggg     180

aaagccccta agtccctgat ctatgctgca tccagtttgc aaagtggggt cccatcaaag     240

ttcagcggca gtggatctgg gacagatttc actctcacca tcagcagcct gcagcctgaa     300

gattttgcaa cttattactg ccaacaatat aatagttacc ccttcacctt cggccaaggg     360

acacgactgg agattaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct     420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc     480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag     540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg     600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                        702


<210> 289
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:289 CDR 1 of variable domain of Heavy chain of
      MAD0008D12

<400> 289
Gly Leu Ile Val Ser Ser Asn Tyr 
1               5               

<210> 290
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:290 CDR 2 of variable domain of Heavy chain of
      MAD0008D12

<400> 290
Ile Tyr Ser Gly Gly Thr Thr 
1               5           

<210> 291
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:291 CDR 3 of variable domain of Heavy chain of
      MAD0008D12

<400> 291
Cys Ala Arg Asp Leu Gln Tyr Tyr Gly Met Asp Val Trp 
1               5                   10              

<210> 292
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:292 CDR 1 of variable domain of Light chain of
      MAD0008D12

<400> 292
Gln Gly Ile Ser Ser Tyr 
1               5       

<210> 293
<400> 293
000

<210> 294
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:294 CDR 3 of variable domain of Light chain of
      MAD0008D12

<400> 294
Cys Arg His Leu Asn Ser Tyr Pro Pro Ile Thr Phe 
1               5                   10          

<210> 295
<211> 119
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:295 variable domain of Heavy chain of MAD0008D12

<400> 295
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ile Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Leu Ile Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Gln Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser 
        115                 

<210> 296
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:296 variable domain of Light chain of MAD0008D12

<400> 296
Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Arg His Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 297
<211> 466
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:297 Heavy chain of MAD0008D12

<400> 297
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ile Val 
        35                  40                  45              
Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Leu Ile Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Asp Leu Gln Tyr Tyr Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 
Gly Lys 
465     

<210> 298
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:298 Light chain of MAD0008D12

<400> 298
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              
Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Arg His Leu Asn Ser 
            100                 105                 110         
Tyr Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 299
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:299 leader sequence of Heavy chain of MAD0008D12

<400> 299
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 300
<211> 357
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:300 variable domain of Heavy chain of MAD0008D12

<400> 300
gaggtgcagc tggtggagtc tgggggaggc ttgatccagc ctggggggtc cctgagactc      60

tcctgtgcag cctctgggct cattgtcagt agtaactaca tgagttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcactt atttatagtg gaggaaccac atactacgca     180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac tctgtatctt     240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatcttcaa     300

tactacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc agcctcc        357


<210> 301
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:301 constant domain of Heavy chain of MAD0008D12

<400> 301
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 302
<211> 1401
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:302 complete sequence of Heavy chain of MAD0008D12

<400> 302
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag      60

gtgcagctgg tggagtctgg gggaggcttg atccagcctg gggggtccct gagactctcc     120

tgtgcagcct ctgggctcat tgtcagtagt aactacatga gttgggtccg ccaggctcca     180

gggaaggggc tggagtgggt ctcacttatt tatagtggag gaaccacata ctacgcagac     240

tccgtgaagg gccgattcac catctccaga gacaattcca agaacactct gtatcttcaa     300

atgaacagcc tgagagccga ggacacggcc gtgtattact gtgcgagaga tcttcaatac     360

tacggtatgg acgtctgggg ccaagggacc acggtcaccg tctcctcagc ctccaccaag     420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     480

ctgggctgcc tggtcaagga ctacttcccc gaacctgtga cggtctcgtg gaactcaggc     540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     660

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac     720

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg    1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac    1140

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg    1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac    1260

ggctccttct tcctctatag caagctcacc gtggacaaga gcaggtggca gcaggggaac    1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc    1380

tccctgtccc cgggtaaatg a                                              1401


<210> 303
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:303 leader sequence of Light chain of MAD0008D12

<400> 303
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 304
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:304 variable domain of Light chain of MAD0008D12

<400> 304
gccatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca     180

aggttcagcg gcagtggatc tgggacacaa ttcactctca caatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtcgacac cttaatagtt accccccgat caccttcggc     300

caagggacac gactggagat taaacgaacg                                      330


<210> 305
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:305 constant domain of Light chain of MAD0008D12

<400> 305
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 306
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:306 complete sequence of Light chain of MAD0008D12

<400> 306
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgcc      60

atccagatga cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc     120

acttgccggg ccagtcaggg cattagcagt tatttagcct ggtatcagca aaaaccaggg     180

aaagccccta agctcctgat ctatgctgca tccactttgc aaagtggggt cccatcaagg     240

ttcagcggca gtggatctgg gacacaattc actctcacaa tcagcagcct gcagcctgaa     300

gattttgcaa cttattactg tcgacacctt aatagttacc ccccgatcac cttcggccaa     360

gggacacgac tggagattaa acgaacggtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 307
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:307 CDR 1 of variable domain of Heavy chain of
      MAD0102I15

<400> 307
Gly Tyr Thr Leu Thr Glu Leu Ser 
1               5               

<210> 308
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:308 CDR 2 of variable domain of Heavy chain of
      MAD0102I15

<400> 308
Phe Asp Pro Glu Asp Gly Glu Thr 
1               5               

<210> 309
<211> 22
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:309 CDR 3 of variable domain of Heavy chain of
      MAD0102I15

<400> 309
Cys Thr Thr Val Gly Phe Pro Asp Tyr Tyr Asp Ser Ser Val Tyr Leu 
1               5                   10                  15      
Arg His Phe Asp Tyr Trp 
            20          

<210> 310
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:310 CDR 1 of variable domain of Light chain of
      MAD0102I15

<400> 310
Gln Gly Ile Ser Ser Tyr 
1               5       

<210> 311
<400> 311
000

<210> 312
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:312 CDR 3 of variable domain of Light chain of
      MAD0102I15

<400> 312
Cys Gln Gln Leu Asn Ser Tyr Pro Arg Thr Phe 
1               5                   10      

<210> 313
<211> 129
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:313 variable domain of Heavy chain of MAD0102I15

<400> 313
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Ala Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Glu Asp Ala Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Val Gly Phe Pro Asp Tyr Tyr Asp Ser Ser Val Tyr Leu Arg 
            100                 105                 110         
His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ser 
    

<210> 314
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:314 variable domain of Light chain of MAD0102I15

<400> 314
Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 

<210> 315
<211> 476
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:315 Heavy chain of MAD0102I15

<400> 315
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Ala Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu 
        35                  40                  45              
Thr Glu Leu Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala 
65                  70                  75                  80  
Gln Arg Phe Gln Gly Arg Val Thr Met Thr Glu Asp Ala Ser Thr Asp 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Thr Thr Val Gly Phe Pro Asp Tyr Tyr Asp Ser Ser Val 
        115                 120                 125             
Tyr Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 
Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     

<210> 316
<211> 233
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:316 Light chain of MAD0102I15

<400> 316
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              
Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser 
            100                 105                 110         
Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 317
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:317 leader sequence of Heavy chain of MAD0102I15

<400> 317
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 318
<211> 387
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:318 variable domain of Heavy chain of MAD0102I15

<400> 318
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agcgaaggtc      60

tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacaggct     120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacgatctac     180

gcacagaggt tccagggcag ggtcaccatg accgaggacg catctacaga cacagcctac     240

atggagctga gtagcctgag atctgaggac acggccgtct attactgtac aacggtggga     300

tttccggatt attatgatag tagtgtttat ttgcggcact ttgactactg gggccaggga     360

accctggtca ccgtctcctc agcttcc                                         387


<210> 319
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:319 constant domain of Heavy chain of MAD0102I15

<400> 319
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 320
<211> 1431
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:320 complete sequence of Heavy chain of MAD0102I15

<400> 320
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagc gaaggtctcc     120

tgcaaggttt ccggatacac cctcactgaa ttatccatgc actgggtgcg acaggctcct     180

ggaaaagggc ttgagtggat gggaggtttt gatcctgaag atggtgaaac gatctacgca     240

cagaggttcc agggcagggt caccatgacc gaggacgcat ctacagacac agcctacatg     300

gagctgagta gcctgagatc tgaggacacg gccgtctatt actgtacaac ggtgggattt     360

ccggattatt atgatagtag tgtttatttg cggcactttg actactgggg ccagggaacc     420

ctggtcaccg tctcctcagc ttccaccaag ggcccatcgg tcttccccct ggcaccctcc     480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc     540

gaacctgtga cggtctcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg     600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc     660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg     720

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca     780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct     900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag    1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc    1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg    1140

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc    1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac    1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc    1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct    1380

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggtaaatg a             1431


<210> 321
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:321 leader sequence of Light chain of MAD0102I15

<400> 321
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 322
<211> 327
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:322 variable domain of Light chain of MAD0102I15

<400> 322
gccatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca     180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtcaacag cttaatagtt acccccgaac ttttggccag     300

gggaccaagc tggagatcaa acgaact                                         327


<210> 323
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:323 constant domain of Light chain of MAD0102I15

<400> 323
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 324
<211> 702
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:324 complete sequence of Light chain of MAD0102I15

<400> 324
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgcc      60

atccagatga cccagtctcc atccttcctg tctgcatctg taggagacag agtcaccatc     120

acttgccggg ccagtcaggg cattagcagt tatttagcct ggtatcagca aaaaccaggg     180

aaagccccta agctcctgat ctatgctgca tccactttgc aaagtggggt cccatcaagg     240

ttcagcggca gtggatctgg gacagaattc actctcacaa tcagcagcct gcagcctgaa     300

gattttgcaa cttattactg tcaacagctt aatagttacc cccgaacttt tggccagggg     360

accaagctgg agatcaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct     420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc     480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag     540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg     600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                        702


<210> 325
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:325 CDR 1 of variable domain of Heavy chain of
      MAD0103J13

<400> 325
Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 326
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:326 CDR 2 of variable domain of Heavy chain of
      MAD0103J13

<400> 326
Leu Ile Pro Ile Phe Gly Thr Ala 
1               5               

<210> 327
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:327 CDR 3 of variable domain of Heavy chain of
      MAD0103J13

<400> 327
Cys Ala Asn Phe Ile Gly Asp Gly Tyr Asn Tyr Glu Glu Asp Tyr Met 
1               5                   10                  15      
Asp Val Trp 
            

<210> 328
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:328 CDR 1 of variable domain of Light chain of
      MAD0103J13

<400> 328
Gln Ser Val Ser Ser Phe 
1               5       

<210> 329
<400> 329
000

<210> 330
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:330 CDR 3 of variable domain of Light chain of
      MAD0103J13

<400> 330
Cys Gln Gln Arg Ser Asn Trp Pro Pro Phe Thr Phe 
1               5                   10          

<210> 331
<211> 126
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:331 variable domain of Heavy chain of MAD0103J13

<400> 331
Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Leu Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Asn Phe Ile Gly Asp Gly Tyr Asn Tyr Glu Glu Asp Tyr Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125     

<210> 332
<211> 110
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:332 variable domain of Light chain of MAD0103J13

<400> 332
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105                 110 

<210> 333
<211> 473
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:333 Heavy chain of MAD0103J13

<400> 333
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Gly Leu Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Asn Phe Ile Gly Asp Gly Tyr Asn Tyr Glu Glu Asp 
        115                 120                 125             
Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
225                 230                 235                 240 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             

<210> 334
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:334 Light chain of MAD0103J13

<400> 334
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              
Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  
Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
            100                 105                 110         
Trp Pro Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 335
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:335 leader sequence of Heavy chain of MAD0103J13

<400> 335
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 336
<211> 378
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:336 variable domain of Heavy chain of MAD0103J13

<400> 336
caggtgcagc tgcaggagtc gggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc      60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcaactgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggaggg ctcatcccta tctttggtac agcaaactac     180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac     240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaattttata     300

ggggatggct acaattacga ggaggactac atggacgtct ggggcaaagg gaccacggtc     360

actgtctcct cagcttcc                                                   378


<210> 337
<211> 987
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:337 constant domain of Heavy chain of MAD0103J13

<400> 337
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      60

gcggccctgg gctgcctggt caaggactac ttccccgaac ctgtgacggt ctcgtggaac     120

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     180

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     240

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct     300

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     360

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     420

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     480

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     540

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     600

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     660

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     720

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     780

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     840

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     900

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     960

agcctctccc tgtccccggg taaatga                                         987


<210> 338
<211> 1422
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:338 complete sequence of Heavy chain of MAD0103J13

<400> 338
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      60

gtgcagctgc aggagtcggg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc     120

tgcaaggctt ctggaggcac cttcagcagc tatgctatca actgggtgcg acaggcccct     180

ggacaagggc ttgagtggat gggagggctc atccctatct ttggtacagc aaactacgca     240

cagaagttcc agggcagagt cacgattacc gcggacgaat ccacgagcac agcctacatg     300

gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgaa ttttataggg     360

gatggctaca attacgagga ggactacatg gacgtctggg gcaaagggac cacggtcact     420

gtctcctcag cttccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     480

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaacctgtg     540

acggtctcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga     720

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc     780

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     960

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg    1020

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa    1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc    1140

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc    1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg    1260

cctcccgtgc tggactccga cggctccttc ttcctctata gcaagctcac cgtggacaag    1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac    1380

cactacacgc agaagagcct ctccctgtcc ccgggtaaat ga                       1422


<210> 339
<211> 57
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:339 leader sequence of Light chain of MAD0103J13

<400> 339
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcc        57


<210> 340
<211> 330
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:340 variable domain of Light chain of MAD0103J13

<400> 340
gaaattgtga tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc agcttcttag cctggtacca acagaaacct     120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc     180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct     240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccatt cactttcggc     300

cctgggacca aagtggatat caaacgaact                                      330


<210> 341
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:341 constant domain of Light chain of MAD0103J13

<400> 341
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     300

aacaggggag agtgttag                                                   318


<210> 342
<211> 705
<212> DNA
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:342 complete sequence of Light chain of MAD0103J13

<400> 342
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgaa      60

attgtgatga cgcagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc     120

tcctgcaggg ccagtcagag tgttagcagc ttcttagcct ggtaccaaca gaaacctggc     180

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg     240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa     300

gattttgcag tttattactg tcagcagcgt agcaactggc ctccattcac tttcggccct     360

gggaccaaag tggatatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 343
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:343 epitope residues 477 to 489 in the RBD of the
      S-protein

<400> 343
Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
1               5                   10              

<210> 344
<211> 1273
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO:344 surface glycoprotein Severe acute respiratory
      syndrome coronavirus 2 QHD43416.1

<400> 344
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                1005            
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                1015                1020                
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                1030                1035                1040
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                1050                1055    
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                1065                1070        
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                1080                1085            
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                1095                1100                
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                1110                1115                1120
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                1130                1135    
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                1145                1150        
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                1160                1165            
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                1175                1180                
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                1190                1195                1200
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                1210                1215    
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                1225                1230        
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                1240                1245            
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                1255                1260                
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                1270            

