               SEQUENCE LISTING

<110> EYEVENSYS

<120> CONSTRUCTION D’ADN POUR LE TRAITEMENT DE PATHOLOGIES OCULAIRES

<130> PR90278

<150> FR2006898
<151> 2020-06-30

<160> 31

<170> BiSSAP 1.3.2

<210> 1
<211> 1296
<212> DNA
<213> Artificial Sequence

<223> "sequence nucleotidique codant pour l’Aflibercept"

<220> 
<223> sequence nucleotidique codant pour l’Aflibercept

<400> 1
agtgatacag gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg      60

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact     120

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt     180

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa     240

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccaataca     300

atcatagatg tcgttctgag tccgtctcat ggaattgaac tatctgttgg agaaaagctt     360

gtcttaaatt gtacagcaag aactgaacta aatgtgggga ttgacttcaa ctgggaatac     420

ccttcttcga agcatcagca taagaaactt gtaaaccgag acctaaaaac ccagtctggg     480

agtgagatga agaaattttt gagcacctta actatagatg gtgtaacccg gagtgaccaa     540

ggattgtaca cctgtgcagc atccagtggg ctgatgacca agaagaacag cacatttgtc     600

agggtccatg aaaaagacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     660

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     720

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     780

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     840

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     900

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     960

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg    1020

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc    1080

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct    1140

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc    1200

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac    1260

tacacgcaga agagcctctc cctgtccccg ggtaaa                              1296


<210> 2
<211> 1300
<212> DNA
<213> Artificial Sequence

<223> "sequence nucleotidique codant pour l’Aflibercept"

<220> 
<223> sequence nucleotidique codant pour l’Aflibercept

<400> 2
cagcgacacc ggcagaccct tcgtggaaat gtacagcgag atccccgaga tcatccacat      60

gaccgagggc cgcgagctgg tgatcccttg cagagtgacc agccccaaca tcaccgtgac     120

actgaagaag ttccctctgg acacactgat ccccgacggc aagaggatca tctgggacag     180

cagaaagggc ttcatcatca gcaacgccac atacaaagag atcggactgc tgacatgcga     240

ggccaccgtg aacggccatc tgtacaagac caactatctg acccaccgcc agaccaacac     300

catcatcgac gtggtgctga gccccagcca cggcatcgag ctgagcgtgg gcgagaagct     360

ggtgctgaac tgcaccgcca gaaccgagct gaatgtgggc atcgacttca actgggagta     420

ccccagctcc aagcaccagc acaagaaact ggtgaaccgg gatctgaaaa cccagagcgg     480

cagcgagatg aagaagtttc tgagcacact gaccatcgac ggcgtgacca gaagcgacca     540

aggactgtac acatgcgccg ccagcagcgg actgatgacc aagaagaaca gcacattcgt     600

ccgggtgcac gagaaggaca agacccacac atgcccacca tgcccagccc cagagctgct     660

gggaggcccc tccgtgtttc tgttccctcc aaagcccaag gacactctga tgatcagcag     720

aacccccgaa gtgacatgcg tggtggtgga cgtgtcccac gaggacccag aagtgaagtt     780

caattggtac gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca     840

gtacaacagc acatacagag tggtgtccgt gctgaccgtg ctgcaccaag actggctgaa     900

cggcaaagag tacaagtgca aagtctccaa caaggctctg ccagccccca tcgaaaagac     960

catcagcaag gccaagggcc agcctcgcga gccccaagtg tacacactgc ctccaagccg    1020

ggacgagctg accaagaatc aagtgtctct gacatgtctg gtgaaaggct tctaccccag    1080

cgatatcgcc gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc    1140

tcccgtgctg gacagcgacg gcagcttctt tctgtactcc aaactgaccg tggacaagag    1200

cagatggcag caaggcaacg tgttcagctg cagcgtgatg cacgaggctc tgcacaacca    1260

ctacacccag aagtctctgt ctctgagccc cggcaagtga                          1300


<210> 3
<211> 432
<212> PRT
<213> Artificial Sequence

<223> sequence peptidique de l’Aflibercept

<220> 
<223> sequence peptidique de l’Aflibercept

<400> 3
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      
Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         
Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             
Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 
His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 
Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     
Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         
Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430         



<210> 4
<211> 23
<212> PRT
<213> Artificial Sequence

<223> sequence peptidique du peptide signal TPA

<220> 
<223> sequence peptidique du peptide signal TPA

<400> 4
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      
Ala Val Phe Val Ser Pro Ser 
            20              

<210> 5
<211> 68
<212> DNA
<213> Artificial Sequence

<223> "sequence nucleotidique codant pour le peptide signal TPA"

<220> 
<223> sequence nucleotidique codant pour le peptide signal TPA

<400> 5
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt     60

tcgcccag                                                              68


<210> 6
<211> 1032
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la Decorine"

<220> 
<223> Sequence nucleotidique codant pour la Decorine

<400> 6
ggaccgtttc aacagagagg cttatttgac tttatgctag aagatgaggc ttctgggata      60

ggcccagaag ttcctgatga ccgcgacttc gagccctccc taggcccagt gtgccccttc     120

cgctgtcaat gccatcttcg agtggtccag tgttctgatt tgggtctgga caaagtgcca     180

aaggatcttc cccctgacac aactctgcta gacctgcaaa acaacaaaat aaccgaaatc     240

aaagatggag actttaagaa cctgaagaac cttcacgcat tgattcttgt caacaataaa     300

attagcaaag ttagtcctgg agcatttaca cctttggtga agttggaacg actttatctg     360

tccaagaatc agctgaagga attgccagaa aaaatgccca aaactcttca ggagctgcgt     420

gcccatgaga atgagatcac caaagtgcga aaagttactt tcaatggact gaaccagatg     480

attgtcatag aactgggcac caatccgctg aagagctcag gaattgaaaa tggggctttc     540

cagggaatga agaagctctc ctacatccgc attgctgata ccaatatcac cagcattcct     600

caaggtcttc ctccttccct tacggaatta catcttgatg gcaacaaaat cagcagagtt     660

gatgcagcta gcctgaaagg actgaataat ttggctaagt tgggattgag tttcaacagc     720

atctctgctg ttgacaatgg ctctctggcc aacacgcctc atctgaggga gcttcacttg     780

gacaacaaca agcttaccag agtacctggt gggctggcag agcataagta catccaggtt     840

gtctaccttc ataacaacaa tatctctgta gttggatcaa gtgacttctg cccacctgga     900

cacaacacca aaaaggcttc ttattcgggt gtgagtcttt tcagcaaccc ggtccagtac     960

tgggagatac agccatccac cttcagatgt gtctacgtgc gctctgccat tcaactcgga    1020

aactataagt aa                                                        1032


<210> 7
<211> 1035
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la Decorine"

<220> 
<223> Sequence nucleotidique codant pour la Decorine

<400> 7
ggaccgtttc aacagagagg cttatttgac tttatgctag aagatgaggc cagcggcatc      60

ggccccgaag tgcccgatga tagagatttc gagccctctc tgggccccgt gtgtcctttc     120

agatgccagt gtcatctgag agtggtgcag tgcagcgatc tgggcctcga caaagtgcct     180

aaggatctgc ctccagacac cacactgctg gatctgcaga acaacaagat caccgagatc     240

aaggacggcg actttaagaa tctgaagaat ctccacgctc tgatcctcgt gaacaacaaa     300

atctccaaag tgtctcccgg cgctttcacc cctctggtca agctggaacg gctgtatctg     360

agcaagaacc agctgaaaga actgcccgag aagatgccca agacactgca agagctgaga     420

gcccacgaga acgagatcac caaagtgcgg aaagtgacat tcaacgggct gaaccagatg     480

atcgtgatcg agctgggcac caatcctctg aagtcctccg gaatcgagaa cggcgccttc     540

caaggcatga agaagctgag ctacatccgg atcgccgaca ccaacatcac cagcattcct     600

caagggctgc ctccatctct gaccgagctg catctggacg gcaacaagat ttccagagtg     660

gacgccgcct ctctgaaggg actgaacaat ctggccaaac tgggactgag cttcaacagc     720

atcagcgccg tggacaacgg ctctctggcc aacacaccac atctgcggga actccatctg     780

gataacaaca agctgaccag agttcccggc ggactggccg agcacaagta catccaagtg     840

gtgtatctcc acaacaacaa tatcagcgtc gtgggcagca gcgatttctg ccctccggga     900

cacaatacca agaaggccag ctacagcgga gtgtctctgt tcagcaatcc cgtgcagtac     960

tgggagatcc agcctagcac attcagatgc gtgtacgtgc ggagcgccat ccagctgggc    1020

aactacaagt gatga                                                     1035


<210> 8
<211> 343
<212> PRT
<213> Artificial Sequence

<223> Sequence peptidique de la Decorine

<220> 
<223> Sequence peptidique de la Decorine

<400> 8
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
1               5                   10                  15      
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
            20                  25                  30          
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
        35                  40                  45              
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
    50                  55                  60                  
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
65                  70                  75                  80  
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
                85                  90                  95      
Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
            100                 105                 110         
Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
        115                 120                 125             
Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
    130                 135                 140                 
Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
145                 150                 155                 160 
Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
                165                 170                 175     
Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
            180                 185                 190         
Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
        195                 200                 205             
Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
    210                 215                 220                 
Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
225                 230                 235                 240 
Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
                245                 250                 255     
Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
            260                 265                 270         
Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
        275                 280                 285             
Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
    290                 295                 300                 
Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
305                 310                 315                 320 
Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
                325                 330                 335     
Ile Gln Leu Gly Asn Tyr Lys 
            340             

<210> 9
<211> 1032
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la Decorine"

<220> 
<223> Sequence nucleotidique codant pour la Decorine

<400> 9
ggaccgtttc aacagagagg cttatttgac tttatgctag aagatgaggc ctctggaatc      60

ggacctgagg tgcccgacga cagagacttc gaaccttctc tgggccctgt gtgccccttc     120

agatgccagt gtcatctgag agtggtgcag tgcagcgacc tgggccttga taaggtgccc     180

aaggacctgc ctcctgacac cacactgctg gacctgcaga acaacaagat caccgagatc     240

aaggacggcg acttcaagaa cctgaagaat ctgcacgccc tgatcctggt caacaacaaa     300

atcagcaagg tgtcccctgg cgccttcaca cctctggtca agctggaaag actgtacctg     360

agcaagaacc agctgaaaga actgcccgag aagatgccca agacactgca agagctgcgg     420

gcccacgaga acgagatcac caaagtgcgg aaagtgacct tcaacggcct gaaccagatg     480

atcgtgatcg agctgggcac caatcctctg aagtccagcg gcattgagaa cggcgccttc     540

cagggcatga agaagctgag ctacatccgg atcgccgaca ccaacatcac cagcattcct     600

cagggcctgc ctccaagcct gacagagctg catctggacg gcaacaagat tagcagagtg     660

gacgccgcct ctctgaaggg cctgaacaat ctggccaaac tgggcctgag cttcaacagc     720

atcagcgccg tggataacgg cagcctggcc aacacacctc acctgaggga actgcacctg     780

gataacaaca agctgaccag agtgcctggc ggactggccg agcacaagta catccaggtg     840

gtgtatctcc acaacaacaa catctccgtc gtgggcagca gcgacttctg tcctcctggc     900

cacaatacca agaaggccag ctactctggc gtgtccctgt tcagcaaccc cgtgcagtac     960

tgggagatcc agcctagcac ctttagatgc gtgtacgtgc ggagcgccat ccagctgggc    1020

aactacaaat ga                                                        1032


<210> 10
<211> 1032
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la Decorine"

<220> 
<223> Sequence nucleotidique codant pour la Decorine

<400> 10
ggaccgtttc aacagagagg cttatttgac tttatgctag aagacgaggc tagcggaatt      60

ggacctgaag tgcccgacga ccgcgatttt gaaccatcac tgggacctgt ctgccccttt     120

agatgtcagt gccacctgag ggtggtgcag tgttctgacc tgggcctgga taaggtgcca     180

aaggacctgc cccctgatac cacactgctg gacctgcaga acaataagat caccgagatc     240

aaggacggcg atttcaagaa tctgaagaac ctgcacgccc tgatcctggt gaacaataag     300

atctctaagg tgagcccagg cgcctttacc cccctggtga agctggagag actgtacctg     360

agcaagaatc agctgaagga gctgcccgag aagatgccta agacactgca ggagctgcgg     420

gcccacgaga acgagatcac caaggtgaga aaggtgacat tcaatggcct gaaccagatg     480

atcgtgatcg agctgggcac caatcccctg aagagctccg gcatcgagaa cggcgccttt     540

cagggcatga agaagctgtc ctatatccgg atcgccgaca ccaatatcac atctatccct     600

cagggcctgc cacccagcct gacagagctg cacctggacg gcaacaagat cagcagagtg     660

gatgccgcct ccctgaaggg cctgaacaat ctggccaagc tgggcctgtc cttcaactcc     720

atctctgccg tggacaatgg ctctctggcc aacacccctc acctgaggga gctgcacctg     780

gataacaata agctgacacg cgtgccaggc ggcctggcag agcacaagta catccaggtg     840

gtgtatctgc acaacaataa catctccgtg gtgggctcta gcgatttctg ccctccaggc     900

cacaatacaa agaaggccag ctactccggc gtgtccctgt tttctaaccc tgtgcagtat     960

tgggagatcc agccctctac ttttcggtgc gtctatgtca ggtccgccat tcagctgggg    1020

aactacaaat aa                                                        1032


<210> 11
<211> 1032
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la Decorine"

<220> 
<223> Sequence nucleotidique codant pour la Decorine

<400> 11
ggaccgtttc aacagagagg cttatttgac tttatgctag aagacgaggc cagcggcatc      60

ggccccgagg tgcccgacga ccgcgacttc gagcccagcc tgggccccgt gtgccccttc     120

cgctgccagt gccacctgcg cgtggtgcag tgcagcgacc tgggcctgga caaggtgccc     180

aaggacctgc cccccgacac caccctgctg gacctgcaga acaacaagat caccgagatc     240

aaggacggcg acttcaagaa cctgaagaac ctgcacgccc tgatcctggt gaacaacaag     300

atcagcaagg tgagccccgg cgccttcacc cccctggtga agctggagcg cctgtacctg     360

agcaagaacc agctgaagga gctgcccgag aagatgccca agaccctgca ggagctgcgc     420

gcccacgaga acgagatcac caaggtgcgc aaggtgacct tcaacggcct gaaccagatg     480

atcgtgatcg agctgggcac caaccccctg aagagcagcg gcatcgagaa cggcgccttc     540

cagggcatga agaagctgag ctacatccgc atcgccgaca ccaacatcac cagcatcccc     600

cagggcctgc cccccagcct gaccgagctg cacctggacg gcaacaagat cagccgcgtg     660

gacgccgcca gcctgaaggg cctgaacaac ctggccaagc tgggcctgag cttcaacagc     720

atcagcgccg tggacaacgg cagcctggcc aacacccccc acctgcgcga gctgcacctg     780

gacaacaaca agctgacccg cgtgcccggc ggcctggccg agcacaagta catccaggtg     840

gtgtacctgc acaacaacaa catcagcgtg gtgggcagca gcgacttctg cccccccggc     900

cacaacacca agaaggccag ctacagcggc gtgagcctgt tcagcaaccc cgtgcagtac     960

tgggagatcc agcccagcac cttccgctgc gtgtacgtgc gcagcgccat ccagctgggc    1020

aactacaagt aa                                                        1032


<210> 12
<211> 1032
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la Decorine"

<220> 
<223> Sequence nucleotidique codant pour la Decorine

<400> 12
ggaccgtttc aacagagagg cttatttgac tttatgctag aagatgaggc gagtggcatt      60

ggacctgaag tacccgatga tagagacttt gaaccatcat tgggcccagt ttgccctttt     120

aggtgtcagt gccacctccg ggtagttcaa tgcagcgatt tgggactcga taaagtaccg     180

aaagacttgc caccggacac aacattgctc gatcttcaaa acaacaagat cactgaaata     240

aaggatggag actttaaaaa tctgaagaat ttgcacgccc tcatcctggt caacaacaag     300

atcagcaagg tgtcccctgg agcattcacg cccctcgtaa agttggaacg cctctacctg     360

tctaagaacc agttgaaaga actgcccgag aagatgccta aaactctgca agagcttaga     420

gctcatgaaa atgaaattac caaggttcgg aaggtaacct ttaacggtct taaccagatg     480

atagtcattg agttgggcac gaacccattg aaatcttctg gcatagaaaa cggggctttc     540

caggggatga aaaaactctc atatatccgc atcgcggata ccaacatcac atctatacct     600

caaggtttgc ccccgagttt gaccgagctt cacctggatg gcaacaagat aagccgggtc     660

gacgctgcct cactcaaagg gctcaataat ctggcgaaac tggggttgag tttcaattca     720

atatctgctg tcgacaacgg ctcacttgcg aacacacccc atcttaggga acttcatctg     780

gacaacaaca agttgacacg ggttcctggg ggactcgctg aacataaata tatacaggtc     840

gtttatctcc ataataataa tatcagcgtt gtaggctcat ctgacttctg ccctccaggc     900

cataatacaa agaaagcgtc atacagtggc gtcagtttgt tctctaaccc ggttcagtat     960

tgggagattc aaccgtccac ttttcggtgc gtttacgtga ggagtgcgat tcagctgggt    1020

aactataagt aa                                                        1032


<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<223> Sequence peptidique du peptide signal natif de la Decorine

<220> 
<223> Sequence peptidique du peptide signal natif de la Decorine

<400> 13
Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      



<210> 14
<211> 48
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour le peptide signal natif de la Decorine"

<220> 
<223> Sequence nucleotidique codant pour le peptide signal natif de la
      Decorine

<400> 14
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggct                  48


<210> 15
<211> 2040
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la transferrine"

<220> 
<223> Sequence nucleotidique codant pour la transferrine

<400> 15
gtccctgata aaactgtgag atggtgtgca gtgtcggagc atgaggccac taagtgccag      60

agtttccgcg accatatgaa aagcgtcatt ccatccgatg gtcccagtgt tgcttgtgtg     120

aagaaagcct cctaccttga ttgcatcagg gccattgcgg caaacgaagc ggatgctgtg     180

acactggatg caggtttggt gtatgatgct tacctggctc ccaataacct gaagcctgtg     240

gtggcagagt tctatgggtc aaaagaggat ccacagactt tctattatgc tgttgctgtg     300

gtgaagaagg atagtggctt ccagatgaac cagcttcgag gcaagaagtc ctgccacacg     360

ggtctaggca ggtccgctgg gtggaacatc cccataggct tactttactg tgacttacct     420

gagccacgta aacctcttga gaaagcagtg gccaatttct tctcgggcag ctgtgcccct     480

tgtgcggatg ggacggactt cccccagctg tgtcaactgt gtccagggtg tggctgctcc     540

acccttaacc aatacttcgg ctactcggga gccttcaagt gtctgaagga tggtgctggg     600

gatgtggcct ttgtcaagca ctcgactata tttgagaact tggcaaacaa ggctgacagg     660

gaccagtatg agctgctttg cctggacaac acccggaagc cggtagatga atacaaggac     720

tgccacttgg cccaggtccc ttctcatacc gtcgtggccc gaagtatggg cggcaaggag     780

gacttgatct gggagcttct caaccaggcc caggaacatt ttggcaaaga caaatcaaaa     840

gaattccaac tattcagctc tcctcatggg aaggacctgc tgtttaagga ctctgcccac     900

gggtttttaa aagtcccccc caggatggat gccaagatgt acctgggcta tgagtatgtc     960

actgccatcc ggaatctacg ggaaggcaca tgcccagaag ccccaacaga tgaatgcaag    1020

cctgtgaagt ggtgtgcgct gagccaccac gagaggctca agtgtgatga gtggagtgtt    1080

aacagtgtag ggaaaataga gtgtgtatca gcagagacca ccgaagactg catcgccaag    1140

atcatgaatg gagaagctga tgccatgagc ttggatggag ggtttgtcta catagcgggc    1200

aagtgtggtc tggtgcctgt cttggcagaa aactacaata agagcgataa ttgtgaggat    1260

acaccagagg cagggtattt tgctatagca gtggtgaaga aatcagcttc tgacctcacc    1320

tgggacaatc tgaaaggcaa gaagtcctgc catacggcag ttggcagaac cgctggctgg    1380

aacatcccca tgggcctgct ctacaataag atcaaccact gcagatttga tgaatttttc    1440

agtgaaggtt gtgcccctgg gtctaagaaa gactccagtc tctgtaagct gtgtatgggc    1500

tcaggcctaa acctgtgtga acccaacaac aaagagggat actacggcta cacaggcgct    1560

ttcaggtgtc tggttgagaa gggagatgtg gcctttgtga aacaccagac tgtcccacag    1620

aacactgggg gaaaaaaccc tgatccatgg gctaagaatc tgaatgaaaa agactatgag    1680

ttgctgtgcc ttgatggtac caggaaacct gtggaggagt atgcgaactg ccacctggcc    1740

agagccccga atcacgctgt ggtcacacgg aaagataagg aagcttgcgt ccacaagata    1800

ttacgtcaac agcagcacct atttggaagc aacgtaactg actgctcggg caacttttgt    1860

ttgttccggt cggaaaccaa ggaccttctg ttcagagatg acacagtatg tttggccaaa    1920

cttcatgaca gaaacacata tgaaaaatac ttaggagaag aatatgtcaa ggctgttggt    1980

aacctgagaa aatgctccac ctcatcactc ctggaagcct gcactttccg tagaccttaa    2040


<210> 16
<211> 2043
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour la transferrine"

<220> 
<223> Sequence nucleotidique codant pour la transferrine

<400> 16
gtgccagata agacagttcg ttggtgcgcc gtgtctgagc acgaggccac aaagtgccag      60

agcttccggg accacatgaa gtctgtgatc cctagcgacg gcccttccgt ggcttgtgtg     120

aagaaggcca gctatctgga ctgcatcaga gccattgccg ccaacgaagc cgatgccgtt     180

acactggatg ccggactggt gtacgatgcc tatctggccc caaacaatct gaagcccgtg     240

gtcgccgagt tctacggctc taaagaggac cctcagacat tctactacgc cgtggccgtg     300

gtcaagaagg acagcggctt tcagatgaac cagctgcggg gcaagaagtc ttgtcacacc     360

ggacttggaa gaagcgccgg ctggaatatc cccatcggac tgctgtactg cgatctgccc     420

gagcctagaa agcctctgga aaaggccgtg gccaacttct tctctggctc ttgtgcccct     480

tgcgccgatg gcacagattt tccacagctc tgtcagctgt gtcccggctg tggctgtagc     540

acactgaacc agtactttgg ctacagcggc gccttcaagt gtctgaaaga tggtgctggc     600

gacgtggcct tcgtgaagca cagcacaatc ttcgagaatc tggccaacaa ggccgaccgg     660

gatcagtacg aactgctgtg cctcgacaac accagaaagc cagtggacga gtacaaggac     720

tgccatctgg ctcaagtgcc tagccacaca gtggttgcca gatccatggg cggcaaagag     780

gatctgatct gggagctgct gaatcaagcc caagagcact tcggcaagga caagagcaaa     840

gagttccagc tgttcagcag ccctcacggc aaggatctgc tgttcaagga tagcgcccac     900

ggatttctga aagtgcctcc tcggatggac gccaagatgt atctgggcta cgagtacgtg     960

accgccatcc ggaatctgag agaaggcaca tgcccagagg ctcccaccga tgagtgtaaa    1020

ccagtgaagt ggtgcgctct gtctcaccac gagagactga agtgtgacga gtggtccgtg    1080

aacagcgtgg gcaagattga gtgtgtgtcc gccgagacaa ccgaggactg tatcgccaag    1140

atcatgaacg gcgaggccga cgctatgtct ctggatggcg gatttgtgta cattgccgga    1200

aagtgtggac tggtgccagt gctggccgag aactacaaca agagcgacaa ctgcgaggat    1260

accccagagg ccggatattt tgccgtggca gtcgtgaaga agtccgccag cgatctgaca    1320

tgggacaatc tcaagggcaa gaaaagctgc cacaccgccg tgggaagaac agccggatgg    1380

aacattccta tggggctgct gtacaacaaa atcaaccact gccgcttcga cgagttcttc    1440

agcgaaggat gtgctcccgg cagcaagaaa gacagctctc tgtgcaagct gtgcatgggc    1500

agcggactga atctgtgcga gcccaacaac aaagagggct actacggcta caccggggcc    1560

tttagatgtc tggttgagaa gggcgacgtt gcatttgtga aacaccagac cgtgcctcag    1620

aacaccggcg gcaagaatcc cgatccttgg gccaagaatc tgaacgagaa ggactatgag    1680

ctgctctgtc tggacggcac ccggaaacca gtggaagaat acgccaactg tcatctggca    1740

agagccccaa atcacgccgt cgtgaccaga aaggacaaag aggcttgcgt ccacaagatt    1800

ctgcggcagc agcagcatct gttcggcagc aatgtgaccg actgcagcgg caacttctgt    1860

ctgttcagaa gcgagacaaa ggatctcctc ttccgcgacg ataccgtgtg tctcgccaag    1920

ctgcacgacc ggaacacata cgagaagtat ctgggagaag agtatgtgaa ggctgtgggc    1980

aatctgcgga agtgcagcac atcttctctg ctcgaggctt gcacatttcg gcggccttga    2040

tga                                                                  2043


<210> 17
<211> 679
<212> PRT
<213> Artificial Sequence

<223> Sequence peptidique de la transferrine humaine

<220> 
<223> Sequence peptidique de la transferrine humaine

<400> 17
Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu His Glu Ala 
1               5                   10                  15      
Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val Ile Pro Ser 
            20                  25                  30          
Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys 
        35                  40                  45              
Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala 
    50                  55                  60                  
Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val 
65                  70                  75                  80  
Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr 
                85                  90                  95      
Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu 
            100                 105                 110         
Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
        115                 120                 125             
Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys 
    130                 135                 140                 
Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro 
145                 150                 155                 160 
Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly 
                165                 170                 175     
Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe 
            180                 185                 190         
Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val Lys His Ser 
        195                 200                 205             
Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu 
    210                 215                 220                 
Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp 
225                 230                 235                 240 
Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala Arg Ser Met 
                245                 250                 255     
Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu 
            260                 265                 270         
His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro 
        275                 280                 285             
His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys 
    290                 295                 300                 
Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val 
305                 310                 315                 320 
Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr 
                325                 330                 335     
Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His His Glu Arg 
            340                 345                 350         
Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys 
        355                 360                 365             
Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly 
    370                 375                 380                 
Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly 
385                 390                 395                 400 
Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp 
                405                 410                 415     
Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Val Ala Val Val 
            420                 425                 430         
Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys 
        435                 440                 445             
Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met 
    450                 455                 460                 
Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe 
465                 470                 475                 480 
Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys 
                485                 490                 495     
Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu 
            500                 505                 510         
Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly 
        515                 520                 525             
Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn Thr Gly Gly 
    530                 535                 540                 
Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys Asp Tyr Glu 
545                 550                 555                 560 
Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu Tyr Ala Asn 
                565                 570                 575     
Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr Arg Lys Asp 
            580                 585                 590         
Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln His Leu Phe 
        595                 600                 605             
Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu Phe Arg Ser 
    610                 615                 620                 
Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys Leu Ala Lys 
625                 630                 635                 640 
Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu Glu Tyr Val 
                645                 650                 655     
Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu 
            660                 665                 670         
Ala Cys Thr Phe Arg Arg Pro 
        675                 

<210> 18
<211> 19
<212> PRT
<213> Artificial Sequence

<223> Sequence peptidique du peptide signal natif de la Transferrine humaine

<220> 
<223> Sequence peptidique du peptide signal natif de la Transferrine
      humaine

<400> 18
Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      
Cys Leu Ala 
            

<210> 19
<211> 57
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour le peptide signal natif de la Transferrine"

<220> 
<223> Sequence nucleotidique codant pour le peptide signal natif de la
      Transferrine

<400> 19
atgaggctcg ccgtgggagc cctgctggtc tgcgccgtcc tggggctgtg tctggct        57


<210> 20
<211> 57
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour le peptide signal de la Transferrine"

<220> 
<223> Sequence nucleotidique codant pour le peptide signal de la
      Transferrine

<400> 20
atgagactgg ctgtgggagc actgcttgtg tgtgctgttc tgggactgtg tctggcc        57


<210> 21
<211> 1249
<212> DNA
<213> Artificial Sequence

<223> "sequence nucleotidique codant pour une proteine de fusion anti-TNF-alpha"

<220> 
<223> sequence nucleotidique codant pour une proteine de fusion
      anti-TNF-alpha

<400> 21
actggtccct cacctagggg acagggagaa gagagatagt gtgtgtcccc aaggaaaata      60

tatccaccct caaaataatt cgatttgctg taccaagtgc cacaaaggaa cctacttgta     120

caatgactgt ccaggcccgg ggcaggatac ggactgcagg gagtgtgaga gcggctcctt     180

caccgcttca gaaaaccacc tcagacactg cctcagctgc tccaaatgcc gaaaggaaat     240

gggtcaggtg gagatctctt cttgcacagt ggaccgggac accgtgtgtg gctgcaggaa     300

gaaccagtac cggcattatt ggagtgaaaa ccttttccag tgcttcaatt gcagcctctg     360

cctcaatggg accgtgcacc tctcctgcca ggagaaacag aacaccgtgt gcacctgcca     420

tgcaggtttc tttctaagag aaaacgagtg tgtctcctgt agtaactgta agaaaagcct     480

ggagtgcacg aagttgtgcc taccccagat tgagaatgtt aagggcactg aggactcagg     540

caccacactg gttccgcgtg gatccgacaa aactcacaca tgcccaccgt gcccagcacc     600

tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat     660

gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga     720

ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg     780

ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga     840

ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat     900

cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc     960

cccatcccgg gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt    1020

ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa    1080

gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt    1140

ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc acgaggctct    1200

gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatga                1249


<210> 22
<211> 415
<212> PRT
<213> Artificial Sequence

<223> sequence peptidique d'une proteine de fusion anti-TNF-alpha

<220> 
<223> sequence peptidique d'une proteine de fusion anti-TNF-alpha

<400> 22
Leu Val Pro His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro 
1               5                   10                  15      
Gln Gly Lys Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys 
            20                  25                  30          
Cys His Lys Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln 
        35                  40                  45              
Asp Thr Asp Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu 
    50                  55                  60                  
Asn His Leu Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met 
65                  70                  75                  80  
Gly Gln Val Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys 
                85                  90                  95      
Gly Cys Arg Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe 
            100                 105                 110         
Gln Cys Phe Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser 
        115                 120                 125             
Cys Gln Glu Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe 
    130                 135                 140                 
Leu Arg Glu Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu 
145                 150                 155                 160 
Glu Cys Thr Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr 
                165                 170                 175     
Glu Asp Ser Gly Thr Thr Leu Val Pro Arg Gly Ser Asp Lys Thr His 
            180                 185                 190         
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        195                 200                 205             
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    210                 215                 220                 
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
225                 230                 235                 240 
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                245                 250                 255     
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            260                 265                 270         
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        275                 280                 285             
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    290                 295                 300                 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
305                 310                 315                 320 
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                325                 330                 335     
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            340                 345                 350         
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        355                 360                 365             
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    370                 375                 380                 
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
385                 390                 395                 400 
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410                 415 

<210> 23
<211> 29
<212> PRT
<213> Artificial Sequence

<223> Sequence peptidique d'un peptide signal

<220> 
<223> Sequence peptidique d'un peptide signal

<400> 23
Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      
Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly 
            20                  25                  

<210> 24
<211> 86
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour le peptide signal de sequence SEQ ID NO : 23"

<220> 
<223> Sequence nucleotidique codant pour le peptide signal de sequence
      SEQ ID NO : 23

<400> 24
atgggcctct ccaccgtgcc tgacctgctg ctgccgctgg tgctcctgga gctgttggtg     60

ggaatatacc cctcaggggt tattgg                                          86


<210> 25
<211> 3642
<212> DNA
<213> Artificial Sequence

<223> "sequence nucleotidique codant pour le facteur H du complement"

<220> 
<223> sequence nucleotidique codant pour le facteur H du complement

<400> 25
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct       60

gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      120

cttggaaata taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      180

aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      240

acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      300

caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      360

cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      420

agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      480

aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      540

agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      600

tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac      660

atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg      720

ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca      780

cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt      840

tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg      900

agatgtacct tgaaaccttg tgattatcca gacattaaac atggaggtct atatcatgag      960

aatatgcgta gaccatactt tccagtagct gtaggaaaat attactccta ttactgtgat     1020

gaacattttg agactccgtc aggaagttac tgggatcaca ttcattgcac acaagatgga     1080

tggtcgccag cagtaccatg cctcagaaaa tgttattttc cttatttgga aaatggatat     1140

aatcaaaatt atggaagaaa gtttgtacag ggtaaatcta tagacgttgc ctgccatcct     1200

ggctacgctc ttccaaaagc gcagaccaca gttacatgta tggagaatgg ctggtctcct     1260

actcccagat gcatccgtgt caaaacatgt tccaaatcaa gtatagatat tgagaatggg     1320

tttatttctg aatctcagta tacatatgcc ttaaaagaaa aagcgaaata tcaatgcaaa     1380

ctaggatatg taacagcaga tggtgaaaca tcaggatcaa ttacatgtgg gaaagatgga     1440

tggtcagctc aacccacgtg cattaaatct tgtgatatcc cagtatttat gaatgccaga     1500

actaaaaatg acttcacatg gtttaagctg aatgacacat tggactatga atgccatgat     1560

ggttatgaaa gcaatactgg aagcaccact ggttccatag tgtgtggtta caatggttgg     1620

tctgatttac ccatatgtta tgaaagagaa tgcgaacttc ctaaaataga tgtacactta     1680

gttcctgatc gcaagaaaga ccagtataaa gttggagagg tgttgaaatt ctcctgcaaa     1740

ccaggattta caatagttgg acctaattcc gttcagtgct accactttgg attgtctcct     1800

gacctcccaa tatgtaaaga gcaagtacaa tcatgtggtc cacctcctga actcctcaat     1860

gggaatgtta aggaaaaaac gaaagaagaa tatggacaca gtgaagtggt ggaatattat     1920

tgcaatccta gatttctaat gaagggacct aataaaattc aatgtgttga tggagagtgg     1980

acaactttac cagtgtgtat tgtggaggag agtacctgtg gagatatacc tgaacttgaa     2040

catggctggg cccagctttc ttcccctcct tattactatg gagattcagt ggaattcaat     2100

tgctcagaat catttacaat gattggacac agatcaatta cgtgtattca tggagtatgg     2160

acccaacttc cccagtgtgt ggcaatagat aaacttaaga agtgcaaatc atcaaattta     2220

attatacttg aggaacattt aaaaaacaag aaggaattcg atcataattc taacataagg     2280

tacagatgta gaggaaaaga aggatggata cacacagtct gcataaatgg aagatgggat     2340

ccagaagtga actgctcaat ggcacaaata caattatgcc cacctccacc tcagattccc     2400

aattctcaca atatgacaac cacactgaat tatcgggatg gagaaaaagt atctgttctt     2460

tgccaagaaa attatctaat tcaggaagga gaagaaatta catgcaaaga tggaagatgg     2520

cagtcaatac cactctgtgt tgaaaaaatt ccatgttcac aaccacctca gatagaacac     2580

ggaaccatta attcatccag gtcttcacaa gaaagttatg cacatgggac taaattgagt     2640

tatacttgtg agggtggttt caggatatct gaagaaaatg aaacaacatg ctacatggga     2700

aaatggagtt ctccacctca gtgtgaaggc cttccttgta aatctccacc tgagatttct     2760

catggtgttg tagctcacat gtcagacagt tatcagtatg gagaagaagt tacgtacaaa     2820

tgttttgaag gttttggaat tgatgggcct gcaattgcaa aatgcttagg agaaaaatgg     2880

tctcaccctc catcatgcat aaaaacagat tgtctcagtt tacctagctt tgaaaatgcc     2940

atacccatgg gagagaagaa ggatgtgtat aaggcgggtg agcaagtgac ttacacttgt     3000

gcaacatatt acaaaatgga tggagccagt aatgtaacat gcattaatag cagatggaca     3060

ggaaggccaa catgcagaga cacctcctgt gtgaatccgc ccacagtaca aaatgcttat     3120

atagtgtcga gacagatgag taaatatcca tctggtgaga gagtacgtta tcaatgtagg     3180

agcccttatg aaatgtttgg ggatgaagaa gtgatgtgtt taaatggaaa ctggacggaa     3240

ccacctcaat gcaaagattc tacaggaaaa tgtgggcccc ctccacctat tgacaatggg     3300

gacattactt cattcccgtt gtcagtatat gctccagctt catcagttga gtaccaatgc     3360

cagaacttgt atcaacttga gggtaacaag cgaataacat gtagaaatgg acaatggtca     3420

gaaccaccaa aatgcttaca tccgtgtgta atatcccgag aaattatgga aaattataac     3480

atagcattaa ggtggacagc caaacagaag ctttattcga gaacaggtga atcagttgaa     3540

tttgtgtgta aacggggata tcgtctttca tcacgttctc acacattgcg aacaacatgt     3600

tgggatggga aactggagta tccaacttgt gcaaaaagat ag                        3642


<210> 26
<211> 1213
<212> PRT
<213> Artificial Sequence

<223> sequence peptidique du facteur H du complement

<220> 
<223> sequence peptidique du facteur H du complement

<400> 26
Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      
Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          
Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              
Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  
Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  
Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         
Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             
Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 
Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 
Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     
Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             
Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 
Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 
Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     
Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         
Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             
Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 
Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 
Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     
Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         
His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             
Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 
Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 
Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     
Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         
Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             
Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 
Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 
Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     
Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         
Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             
Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 
Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 
Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     
Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         
Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             
Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 
Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 
Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     
Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         
Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             
Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 
Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 
Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     
Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         
Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             
Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 
Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 
Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     
Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         
Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 
Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 
Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     
Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         
Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             
Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 
Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     
Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         
Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met Asp Gly 
        995                 1000                1005            
Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg Pro Thr 
    1010                1015                1020                
Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr 
1025                1030                1035                1040
Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg 
                1045                1050                1055    
Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met 
            1060                1065                1070        
Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
        1075                1080                1085            
Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
    1090                1095                1100                
Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
1105                1110                1115                1120
Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
                1125                1130                1135    
Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser 
            1140                1145                1150        
Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys 
        1155                1160                1165            
Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys 
    1170                1175                1180                
Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 
1185                1190                1195                1200
Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                1205                1210            

<210> 27
<211> 18
<212> PRT
<213> Artificial Sequence

<223> Sequence peptidique du peptide signal natif du facteur H

<220> 
<223> Sequence peptidique du peptide signal natif du facteur H

<400> 27
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      
Val Ala 
        

<210> 28
<211> 54
<212> DNA
<213> Artificial Sequence

<223> "Sequence nucleotidique codant pour le peptide signal natif du facteur H"

<220> 
<223> Sequence nucleotidique codant pour le peptide signal natif du
      facteur H

<400> 28
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agca           54


<210> 29
<211> 20
<212> PRT
<213> Artificial Sequence

<223> sequence peptidique du peptide signal du HTLV-1 Env

<220> 
<223> sequence peptidique du peptide signal du HTLV-1 Env

<400> 29
Met Gly Lys Phe Leu Ala Thr Leu Ile Leu Phe Phe Gln Phe Cys Pro 
1               5                   10                  15      
Leu Ile Phe Gly 
            20  

<210> 30
<211> 60
<212> DNA
<213> Artificial Sequence

<223> "sequence nucleotidique codant pour le peptide signal du HTLV-1 Env"

<220> 
<223> sequence nucleotidique codant pour le peptide signal du HTLV-1
      Env

<400> 30
atgggtaagt ttctcgccac tttgatttta ttcttccagt tctgccccct catcttcggt     60


<210> 31
<211> 281
<212> DNA
<213> Artificial Sequence

<223> "sequence de l’origine de replication gamma du plasmide E. coli R6K"

<220> 
<223> sequence de l’origine de replication gamma du plasmide E. coli
      R6K

<400> 31
gatcagcagt tcaacctgtt gatagtatgt actaagctct catgtttaat gtactaagct     60

ctcatgttta atgaactaaa ccctcatggc taatgtacta agctctcatg gctaatgtac    120

taagctctca tgtttcacgt actaagctct catgtttgaa caataaaatt aatataaatc    180

agcaacttaa atagcctcta aggttttaag ttttataaga aaaaaaagaa tatataaggc    240

ttttaaagct tttaaggttt aatggttgtg gacaacaagc c                        281


