                         SEQUENCE LISTING

<110>  Arxx Therapeutics AS
 
<120>  Anti-S100A4 antibodies for the treatment of systemic sclerosis

<130>  P5648PC00

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  CDR-H1 6B12

<400>  1

Asn Asp Tyr Tyr Trp Asn 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CDR-H2 6B12

<400>  2

His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR-H3 6B12

<400>  3

Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR-L1 6B12

<400>  4

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR-L2 6B12

<400>  5

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR-L3 6B12

<400>  6

Gln Gln Gly Asn Ser Leu Pro Arg Thr 
1               5                   


<210>  7
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(138)
<223>  VH region 6B12

<400>  7

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Phe Thr 
        35                  40                  45              


Asn Asp Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Ser Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Arg Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135             


<210>  8
<211>  414
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  misc_feature
<222>  (1)..(414)
<223>  VH region 6B12

<400>  8
atgaaagtgt tgagtctgtt gtacctgttg acagccattc ctggtatcct gtctgatgta       60

cagcttcagg agtcaggacc tggcctcgtg aaaccttctc agtctctgtc tctcacctgc      120

tctgtcactg gcgactcctt caccaatgat tattactgga actggatccg gcagtttcca      180

ggaagcaaac tggaatggat gggccacata ggctacggcg gtaacattaa ctacaaccca      240

tctctcaaaa atcgaatctc catcactcgt gacacatcta agaaccaatt tttcctgagg      300

ttgacttctg tgactactga ggacacagct acatattact gtacaagaga gagtttctat      360

gatggttacc cctttgatta ctggggccaa gggactctgg tcactgtctc tgca            414


<210>  9
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(127)
<223>  VL region 6B12

<400>  9

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Gly Thr Leu 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Ser Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  10
<211>  381
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  misc_feature
<222>  (1)..(381)
<223>  VL region 6B12

<400>  10
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagg aattatttaa actggtatca gcagagacca      180

ggtggaactc ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagtaa cctggaacaa      300

gaagatattg ccacttactt ttgccaacag ggtaattcgc ttcctcggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  11
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Cys Pro Leu Glu Lys Ala Leu Asp Val Met Val Ser Thr Phe 
1               5                   10                  15      


His Lys Tyr Ser Gly Lys Glu Gly Asp Lys Phe Lys Leu Asn Lys Ser 
            20                  25                  30          


Glu Leu Lys Glu Leu Leu Thr Arg Glu Leu Pro Ser Phe Leu Gly Lys 
        35                  40                  45              


Arg Thr Asp Glu Ala Ala Phe Gln Lys Leu Met Ser Asn Leu Asp Ser 
    50                  55                  60                  


Asn Arg Asp Asn Glu Val Asp Phe Gln Glu Tyr Cys Val Phe Leu Ser 
65                  70                  75                  80  


Cys Ile Ala Met Met Cys Asn Glu Phe Phe Glu Gly Phe Pro Asp Lys 
                85                  90                  95      


Gln Pro Arg Lys Lys 
            100     


<210>  12
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Asp Asn Glu Val Asp Phe Gln Glu Tyr Cys Val Phe Leu Ser Cys 
1               5                   10                  15      


Ile Ala Met Met Cys Asn Glu Phe 
            20                  


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Leu Pro Ser Phe Leu Gly Lys Arg Thr 
1               5                   10  


<210>  14
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Gly Phe Pro Asp Lys Gln Pro Arg Lys Lys 
1               5                   10      


<210>  15
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR-H1 5C3

<400>  15

Glu Thr Tyr Met His 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR-H2 5C3

<400>  16

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Asp Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  CDR-H3 5C3

<400>  17

Ser Tyr Ala Met Asp Tyr 
1               5       


<210>  18
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CDR-L1 5C3

<400>  18

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR-L2 5C3

<400>  19

Lys Val Ser Asn Arg Leu Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR-L3 5C3

<400>  20

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  21
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(115)
<223>  VH region 5C3

<400>  21

Glu Ala Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Gln Glu Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Asp Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  22
<211>  345
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(345)
<223>  VH region 5C3

<400>  22

Gly Ala Gly Gly Cys Thr Cys Ala Gly Cys Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Gly Cys Thr 
            20                  25                  30          


Thr Gly Thr Gly Ala Ala Gly Cys Cys Ala Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Thr Gly Thr Cys Ala Ala Gly Thr Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Ala Cys Ala Thr Thr Cys Ala Ala Gly Ala Gly Ala Cys Cys 
                85                  90                  95      


Thr Ala Thr Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Ala Ala Cys Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Ala Ala Gly Gly Ala Thr Thr Gly Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Cys Gly Ala Ala Thr Gly Gly Thr Ala Ala Thr Ala Cys Cys Ala Ala 
                165                 170                 175     


Ala Gly Ala Thr Gly Ala Cys Cys Cys Gly Ala Ala Gly Thr Thr Cys 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Ala Gly Gly Cys Cys Thr Cys Thr Ala 
        195                 200                 205             


Thr Ala Ala Cys Ala Gly Thr Ala Gly Ala Cys Ala Cys Ala Thr Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Ala Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Thr Thr Cys Ala Ala Gly Thr Thr Ala Thr Gly Cys Thr Ala 
    290                 295                 300                 


Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala 
305                 310                 315                 320 


Ala Gly Gly Ala Ala Cys Cys Thr Cys Ala Gly Thr Cys Ala Cys Cys 
                325                 330                 335     


Gly Thr Cys Thr Cys Cys Thr Cys Ala 
            340                 345 


<210>  23
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  VL region 5C3

<400>  23

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Thr Gly Gln Ser 
        35                  40                  45              


Pro Glu Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  24
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody region


<220>
<221>  MISC_FEATURE
<222>  (1)..(336)
<223>  VL region 5C3

<400>  24

Gly Ala Thr Gly Thr Thr Thr Thr Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Ala Ala Cys Thr Cys Cys Ala Cys Thr Cys Thr Cys Cys Cys Thr 
            20                  25                  30          


Gly Cys Cys Thr Gly Thr Cys Ala Gly Thr Cys Thr Thr Gly Gly Ala 
        35                  40                  45              


Gly Ala Thr Cys Ala Ala Gly Cys Cys Thr Cys Cys Ala Thr Cys Thr 
    50                  55                  60                  


Cys Thr Thr Gly Cys Ala Gly Ala Thr Cys Thr Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Ala Gly Thr Ala Thr Thr Gly Thr Ala Cys Ala Thr Ala Gly Thr 
                85                  90                  95      


Ala Ala Thr Gly Gly Ala Ala Ala Cys Ala Cys Cys Thr Ala Thr Thr 
            100                 105                 110         


Thr Ala Gly Ala Ala Thr Gly Gly Thr Ala Cys Cys Thr Gly Cys Ala 
        115                 120                 125             


Gly Ala Ala Ala Ala Cys Ala Gly Gly Cys Cys Ala Gly Thr Cys Thr 
    130                 135                 140                 


Cys Cys Ala Gly Ala Gly Cys Thr Cys Cys Thr Gly Ala Thr Cys Thr 
145                 150                 155                 160 


Ala Cys Ala Ala Ala Gly Thr Thr Thr Cys Cys Ala Ala Cys Cys Gly 
                165                 170                 175     


Ala Cys Thr Cys Thr Cys Thr Gly Gly Gly Gly Thr Cys Cys Cys Ala 
            180                 185                 190         


Gly Ala Cys Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala 
        195                 200                 205             


Gly Thr Gly Gly Ala Thr Cys Ala Gly Gly Gly Ala Cys Ala Gly Ala 
    210                 215                 220                 


Thr Thr Thr Cys Ala Cys Ala Cys Thr Cys Ala Ala Gly Ala Thr Cys 
225                 230                 235                 240 


Ala Gly Cys Ala Gly Ala Gly Thr Gly Gly Ala Gly Gly Cys Thr Gly 
                245                 250                 255     


Ala Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Gly Thr Thr Thr Ala 
            260                 265                 270         


Thr Thr Ala Cys Thr Gly Cys Thr Thr Thr Cys Ala Ala Gly Gly Thr 
        275                 280                 285             


Thr Cys Ala Cys Ala Thr Gly Thr Thr Cys Cys Ala Thr Thr Cys Ala 
    290                 295                 300                 


Cys Gly Thr Thr Cys Gly Gly Cys Thr Cys Gly Gly Gly Gly Ala Cys 
305                 310                 315                 320 


Ala Ala Ala Gly Thr Thr Gly Gly Ala Ala Ala Thr Ala Ala Ala Ala 
                325                 330                 335     


<210>  25
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain


<220>
<221>  misc_feature
<222>  (1)..(446)
<223>  AX-202 complete heavy chain

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Leu Ser Met Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  26
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain


<220>
<221>  misc_feature
<222>  (1)..(214)
<223>  AX-202 complete light chain

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Leu 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  27
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


