                         SEQUENCE LISTING

<110>  Carlsberg A/S
 
<120>  Low diacetyl yeast

<130>  P5459PC00

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ILV2 forward primer


<220>
<221>  primer_bind
<222>  (1)..(19)
<223>  ILV2 forward primer

<400>  1
gccaacgaca caggaagac                                                    19


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ILV2 reverse primer


<220>
<221>  primer_bind
<222>  (1)..(20)
<223>  ILV2 reverse primer

<400>  2
gtacctaaac cacctgatgt                                                   20


<210>  3
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ILV2 S. cerevisiae probe


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  ILV2 S. cerevisiae probe

<400>  3
tgggctgctc aacac                                                        15


<210>  4
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ILV2 S. eubayanus probe


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  ILV2 S. eubayanus probe

<400>  4
acgtacggaa tgtggatt                                                     18


<210>  5
<211>  687
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Ile Arg Gln Ser Thr Leu Lys Asn Phe Ala Ile Lys Arg Cys Phe 
1               5                   10                  15      


Gln His Ile Ala Tyr Arg Asn Thr Pro Ala Met Arg Ser Val Ala Leu 
            20                  25                  30          


Ala Gln Arg Phe Tyr Ser Ser Ser Ser Arg Tyr Tyr Ser Ala Ser Pro 
        35                  40                  45              


Leu Pro Ala Ser Lys Arg Pro Glu Pro Ala Pro Ser Phe Asn Val Asp 
    50                  55                  60                  


Pro Leu Glu Gln Pro Ala Glu Pro Ser Lys Leu Ala Lys Lys Leu Arg 
65                  70                  75                  80  


Ala Glu Pro Asp Met Asp Thr Ser Phe Val Gly Leu Thr Gly Gly Gln 
                85                  90                  95      


Ile Phe Asn Glu Met Met Ser Arg Gln Asn Val Asp Thr Val Phe Gly 
            100                 105                 110         


Tyr Pro Gly Gly Ala Ile Leu Pro Val Tyr Asp Ala Ile His Asn Ser 
        115                 120                 125             


Asp Lys Phe Asn Phe Val Leu Pro Lys His Glu Gln Gly Ala Gly His 
    130                 135                 140                 


Met Ala Glu Gly Tyr Ala Arg Ala Ser Gly Lys Pro Gly Val Val Leu 
145                 150                 155                 160 


Val Thr Ser Gly Pro Gly Ala Thr Asn Val Val Thr Pro Met Ala Asp 
                165                 170                 175     


Ala Phe Ala Asp Gly Ile Pro Met Val Val Phe Thr Gly Gln Val Pro 
            180                 185                 190         


Thr Ser Ala Ile Gly Thr Asp Ala Phe Gln Glu Ala Asp Val Val Gly 
        195                 200                 205             


Ile Ser Arg Ser Cys Thr Lys Trp Asn Val Met Val Lys Ser Val Glu 
    210                 215                 220                 


Glu Leu Pro Leu Arg Ile Asn Glu Ala Phe Glu Ile Ala Thr Ser Gly 
225                 230                 235                 240 


Arg Pro Gly Pro Val Leu Val Asp Leu Pro Lys Asp Val Thr Ala Ala 
                245                 250                 255     


Ile Leu Arg Asn Pro Ile Pro Thr Lys Thr Thr Leu Pro Ser Asn Ala 
            260                 265                 270         


Leu Asn Gln Leu Thr Ser Arg Ala Gln Asp Glu Phe Val Met Gln Ser 
        275                 280                 285             


Ile Asn Lys Ala Ala Asp Leu Ile Asn Leu Ala Lys Lys Pro Val Leu 
    290                 295                 300                 


Tyr Val Gly Ala Gly Ile Leu Asn His Ala Asp Gly Pro Arg Leu Leu 
305                 310                 315                 320 


Lys Glu Leu Ser Asp Arg Ala Gln Ile Pro Val Thr Thr Thr Leu Gln 
                325                 330                 335     


Gly Leu Gly Ser Phe Asp Gln Glu Asp Pro Lys Ser Leu Asp Met Phe 
            340                 345                 350         


Gly Met His Gly Cys Ala Thr Ala Asn Leu Ala Val Gln Asn Ala Asp 
        355                 360                 365             


Leu Ile Ile Ala Val Gly Ala Arg Phe Asp Asp Arg Val Thr Gly Asn 
    370                 375                 380                 


Ile Ser Lys Phe Ala Pro Glu Ala Arg Arg Ala Ala Ala Glu Gly Arg 
385                 390                 395                 400 


Gly Gly Ile Ile His Phe Glu Val Ser Pro Lys Asn Ile Asn Lys Val 
                405                 410                 415     


Val Gln Thr Gln Ile Ala Val Glu Gly Asp Ala Thr Thr Asn Leu Gly 
            420                 425                 430         


Lys Met Met Ser Lys Ile Phe Pro Val Lys Glu Arg Ser Glu Trp Phe 
        435                 440                 445             


Ala Gln Ile Asn Lys Trp Lys Lys Glu Tyr Pro Tyr Ala Tyr Met Glu 
    450                 455                 460                 


Glu Thr Pro Gly Ser Lys Ile Lys Pro Gln Thr Val Ile Lys Lys Leu 
465                 470                 475                 480 


Ser Lys Val Ala Asn Asp Thr Gly Arg His Val Ile Val Thr Thr Gly 
                485                 490                 495     


Val Gly Gln His Gln Met Trp Ala Ala Gln His Trp Thr Trp Arg Asn 
            500                 505                 510         


Pro His Thr Phe Ile Thr Ser Gly Gly Leu Gly Thr Met Gly Tyr Gly 
        515                 520                 525             


Leu Pro Ala Ala Ile Gly Ala Gln Val Ala Lys Pro Glu Ser Leu Val 
    530                 535                 540                 


Ile Asp Ile Asp Gly Asp Ala Ser Phe Asn Met Thr Leu Thr Glu Leu 
545                 550                 555                 560 


Ser Ser Ala Val Gln Ala Gly Thr Pro Val Lys Ile Leu Ile Leu Asn 
                565                 570                 575     


Asn Glu Glu Gln Gly Met Val Thr Gln Trp Gln Ser Leu Phe Tyr Glu 
            580                 585                 590         


His Arg Tyr Ser His Thr His Gln Leu Asn Pro Asp Phe Ile Lys Leu 
        595                 600                 605             


Ala Glu Ala Met Gly Leu Lys Gly Leu Arg Val Lys Lys Gln Glu Glu 
    610                 615                 620                 


Leu Asp Ala Lys Leu Lys Glu Phe Val Ser Thr Lys Gly Pro Val Leu 
625                 630                 635                 640 


Leu Glu Val Glu Val Asp Lys Lys Val Pro Val Leu Pro Met Val Ala 
                645                 650                 655     


Gly Gly Ser Gly Leu Asp Glu Phe Ile Asn Phe Asp Pro Glu Val Glu 
            660                 665                 670         


Arg Gln Gln Thr Glu Leu Arg His Lys Arg Thr Gly Gly Lys His 
        675                 680                 685         


<210>  6
<211>  309
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Leu Arg Ser Leu Leu Gln Ser Gly His Arg Arg Val Val Ala Ser 
1               5                   10                  15      


Ser Cys Ala Thr Met Val Arg Cys Ser Ser Ser Ser Thr Ser Ala Leu 
            20                  25                  30          


Ala Tyr Lys Gln Met His Arg His Ala Thr Arg Pro Pro Leu Pro Thr 
        35                  40                  45              


Leu Asp Thr Pro Ser Trp Asn Ala Asn Ser Ala Val Ser Ser Ile Ile 
    50                  55                  60                  


Tyr Glu Thr Pro Ala Pro Ser Arg Gln Pro Arg Lys Gln His Val Leu 
65                  70                  75                  80  


Asn Cys Leu Val Gln Asn Glu Pro Gly Val Leu Ser Arg Val Ser Gly 
                85                  90                  95      


Thr Leu Ala Ala Arg Gly Phe Asn Ile Asp Ser Leu Val Val Cys Asn 
            100                 105                 110         


Thr Glu Val Lys Asp Leu Ser Arg Met Thr Ile Val Leu Gln Gly Gln 
        115                 120                 125             


Asp Gly Val Ile Glu Gln Ala Arg Arg Gln Ile Glu Asp Leu Val Pro 
    130                 135                 140                 


Val Tyr Ala Val Leu Asp Tyr Thr Asn Ser Glu Ile Val Lys Arg Glu 
145                 150                 155                 160 


Leu Val Met Ala Arg Ile Ser Leu Leu Gly Thr Glu Tyr Phe Glu Asp 
                165                 170                 175     


Leu Leu Leu His His His Thr Ser Thr Asn Ala Gly Ala Ala Asp Ser 
            180                 185                 190         


Gln Glu Leu Val Ala Glu Ile Arg Glu Lys Gln Phe His Pro Ala Asn 
        195                 200                 205             


Leu Pro Ala Ser Glu Val Leu Arg Leu Lys His Glu His Leu Asn Asp 
    210                 215                 220                 


Ile Thr Asn Leu Thr Asn Asn Phe Gly Gly Arg Val Val Asp Ile Ser 
225                 230                 235                 240 


Glu Thr Ser Cys Ile Val Glu Leu Ser Ala Lys Pro Thr Arg Ile Ser 
                245                 250                 255     


Ala Phe Leu Lys Leu Val Glu Pro Phe Gly Val Leu Glu Cys Ala Arg 
            260                 265                 270         


Ser Gly Met Met Ala Leu Pro Arg Thr Pro Leu Lys Thr Ser Thr Glu 
        275                 280                 285             


Glu Ala Ala Asp Glu Asp Glu Lys Ile Ser Glu Ile Val Asp Ile Ser 
    290                 295                 300                 


Gln Leu Pro Pro Gly 
305                 


<210>  7
<211>  309
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  7

Met Leu Arg Ser Leu Leu Gln Ser Gly His Arg Arg Val Ala Ala Ser 
1               5                   10                  15      


Ser Cys Ala Thr Met Val Arg Cys Ser Ser Ser Ser Thr Ser Ala Leu 
            20                  25                  30          


Ala Tyr Lys Gln Met His Arg His Ala Ala Arg Pro Pro Leu Pro Thr 
        35                  40                  45              


Leu Asp Thr Pro Ser Trp Asn Ala Asn Ser Ala Val Ser Ser Ile Ile 
    50                  55                  60                  


Tyr Glu Thr Pro Ala Pro Ser Arg Gln Pro Arg Lys Gln His Val Leu 
65                  70                  75                  80  


Asn Cys Leu Val Gln Asn Glu Pro Gly Val Leu Ser Arg Ile Ser Gly 
                85                  90                  95      


Thr Leu Ala Ala Arg Gly Phe Asn Ile Asp Ser Leu Val Val Cys Asn 
            100                 105                 110         


Thr Glu Val Lys Asp Leu Ser Arg Met Thr Ile Val Leu Gln Gly Gln 
        115                 120                 125             


Asp Gly Val Ile Glu Gln Ala Arg Arg Gln Ile Glu Asp Leu Val Pro 
    130                 135                 140                 


Val Tyr Ala Val Leu Asp Tyr Thr Asn Ser Glu Ile Ile Lys Arg Glu 
145                 150                 155                 160 


Leu Val Met Ala Arg Ile Ser Leu Leu Gly Thr Glu Tyr Phe Glu Asp 
                165                 170                 175     


Leu Leu Leu His His His Thr Ser Thr Ser Ser Gly Gly Ala Asp Ala 
            180                 185                 190         


Asn Glu Leu Val Ala Glu Ile Arg Glu Lys Gln Phe His Pro Ala Asn 
        195                 200                 205             


Leu Pro Ala Ser Glu Ile Leu Arg Leu Lys His Glu His Leu Asn Asp 
    210                 215                 220                 


Val Thr Asn Leu Thr Asn Asn Phe Gly Gly Arg Val Val Asp Ile Ser 
225                 230                 235                 240 


Glu Thr Ser Cys Ile Val Glu Leu Ser Ala Lys Pro Thr Arg Ile Ser 
                245                 250                 255     


Ala Phe Leu Lys Leu Val Glu Pro Phe Gly Val Leu Glu Cys Ala Arg 
            260                 265                 270         


Ser Gly Met Met Ala Leu Pro Arg Thr Pro Leu Lys Thr Ser Ile Glu 
        275                 280                 285             


Glu Ala Ala Asp Glu Asp Glu Lys Ile Asn Glu Ile Val Asp Ile Ser 
    290                 295                 300                 


Gln Leu Pro Pro Gly 
305                 


<210>  8
<211>  395
<212>  PRT
<213>  Saccharomyces Cerevisiae

<400>  8

Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Ile 
1               5                   10                  15      


Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr Ser 
            20                  25                  30          


Arg Pro Ala Ala Arg Phe Val Lys Pro Met Ile Thr Thr Arg Gly Leu 
        35                  40                  45              


Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr Glu Arg Ala 
    50                  55                  60                  


Asp Trp Pro Arg Glu Lys Leu Leu Asp Tyr Phe Lys Asn Asp Thr Phe 
65                  70                  75                  80  


Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr Gly Gln Gly Leu Asn Leu 
                85                  90                  95      


Arg Asp Asn Gly Leu Asn Val Ile Ile Gly Val Arg Lys Asp Gly Ala 
            100                 105                 110         


Ser Trp Lys Ala Ala Ile Glu Asp Gly Trp Val Pro Gly Lys Asn Leu 
        115                 120                 125             


Phe Thr Val Glu Asp Ala Ile Lys Arg Gly Cys Tyr Val Met Asn Leu 
    130                 135                 140                 


Leu Ser Asp Ala Ala Gln Ser Glu Thr Trp Pro Ala Ile Lys Pro Leu 
145                 150                 155                 160 


Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val 
                165                 170                 175     


Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp Val Ile 
            180                 185                 190         


Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg Ser Leu Phe Lys 
        195                 200                 205             


Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala Val Trp Asn Asp Val Thr 
    210                 215                 220                 


Gly Lys Ala His Glu Lys Ala Gln Ala Leu Ala Val Ala Ile Gly Ser 
225                 230                 235                 240 


Gly Tyr Val Tyr Gln Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 
                245                 250                 255     


Tyr Gly Glu Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 
            260                 265                 270         


Ala Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 
        275                 280                 285             


Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile 
    290                 295                 300                 


Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr Thr Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe Lys Asn Ala Leu Lys 
                325                 330                 335     


Pro Val Phe Gln Asp Leu Tyr Glu Ser Thr Lys Asn Gly Thr Glu Thr 
            340                 345                 350         


Lys Arg Ser Leu Glu Phe Asn Ser Gln Pro Asp Tyr Arg Glu Lys Leu 
        355                 360                 365             


Glu Lys Glu Leu Asp Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 
    370                 375                 380                 


Lys Glu Val Arg Lys Leu Arg Pro Glu Asn Gln 
385                 390                 395 


<210>  9
<211>  395
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  9

Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Val 
1               5                   10                  15      


Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr Ser 
            20                  25                  30          


Arg Pro Ala Ala Arg Phe Val Lys Pro Met Val Ala Thr Arg Gly Leu 
        35                  40                  45              


Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr Glu Arg Ala 
    50                  55                  60                  


Asp Trp Pro Arg Glu Lys Leu Leu Asn Tyr Phe Lys Asp Asp Thr Phe 
65                  70                  75                  80  


Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr Gly Gln Gly Leu Asn Leu 
                85                  90                  95      


Arg Asp Asn Gly Leu Asn Val Ile Ile Gly Val Arg Lys Asp Gly Ala 
            100                 105                 110         


Ser Trp Lys Ala Ala Ile Glu Asp Gly Trp Val Pro Gly Gln Asn Leu 
        115                 120                 125             


Phe Ser Val Glu Asp Ala Ile Lys Lys Gly Asn Tyr Val Met Asn Leu 
    130                 135                 140                 


Leu Ser Asp Ala Ala Gln Ser Glu Thr Trp Pro Thr Ile Lys Pro Leu 
145                 150                 155                 160 


Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val 
                165                 170                 175     


Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp Val Ile 
            180                 185                 190         


Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg Ser Leu Phe Lys 
        195                 200                 205             


Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala Val Trp Asn Asp Val Thr 
    210                 215                 220                 


Gly Lys Ala His Glu Lys Ala Gln Ala Leu Ala Val Ala Ile Gly Ser 
225                 230                 235                 240 


Gly Tyr Val Tyr Gln Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 
                245                 250                 255     


Tyr Gly Glu Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 
            260                 265                 270         


Ala Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 
        275                 280                 285             


Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile 
    290                 295                 300                 


Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr Thr Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe Lys Asn Ala Leu Lys 
                325                 330                 335     


Pro Val Phe Gln Asp Leu Tyr Glu Ser Thr Lys Asn Gly Thr Glu Thr 
            340                 345                 350         


Lys Arg Ser Leu Glu Phe Asn Ser Gln Pro Asp Tyr Arg Glu Lys Leu 
        355                 360                 365             


Glu Lys Glu Leu Val Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 
    370                 375                 380                 


Lys Glu Val Arg Lys Leu Arg Pro Glu Asn Lys 
385                 390                 395 


<210>  10
<211>  585
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Cys Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Glu Asp Phe Lys Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Glu Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Lys Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asp Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Ala Asn Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Arg 
            420                 425                 430         


Ala Arg Val Phe Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Arg 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Val Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Arg Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Val Ser 
    530                 535                 540                 


Asp Lys Glu Met Ala Gln Arg Lys Gln Ser Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Asn Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  11
<211>  585
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  11

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Ser Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Asp Asp Phe Gln Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Gln Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Thr Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asn Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Thr Ser Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Lys 
            420                 425                 430         


Ala Arg Val Tyr Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Lys 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Ile Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Lys Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Ile Ser 
    530                 535                 540                 


Glu Gln Glu Met Ser Gln Arg Lys Gln Asn Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Ser Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  12
<211>  585
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Cys Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Glu Asp Phe Lys Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Glu Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Lys Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asp Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Ala Asn Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Arg 
            420                 425                 430         


Ala Arg Val Phe Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Arg 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Val Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Arg Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Val Ser 
    530                 535                 540                 


Asp Lys Glu Met Ala Gln Arg Lys Gln Ser Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Asn Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  13
<211>  585
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  13

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Ser Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Asp Asp Phe Gln Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Gln Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Thr Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asn Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Thr Ser Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Lys 
            420                 425                 430         


Ala Arg Val Tyr Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Lys 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Ile Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Lys Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Ile Ser 
    530                 535                 540                 


Glu Gln Glu Met Ser Gln Arg Lys Gln Asn Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Ser Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  14
<211>  393
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Leu Gln Arg His Ser Leu Lys Leu Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Glu Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Ser Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Thr Pro His Ile Lys Pro Tyr Gly Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ala Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Pro Asp 
            100                 105                 110         


Lys Asn Met Ala Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Glu Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Gln Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Thr Leu Ala Arg Asp Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Lys Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Asn Asn Glu Asp Ile His 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Cys Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Val Asn Tyr Gly Asn 
    370                 375                 380                 


Trp Ser Lys Thr Val Ala Asp Leu Asn 
385                 390             


<210>  15
<211>  393
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Leu Gln Arg His Ser Leu Lys Leu Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Glu Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Ser Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Thr Pro His Ile Lys Pro Tyr Gly Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ala Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Pro Asp 
            100                 105                 110         


Lys Asn Met Ala Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Glu Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Gln Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Thr Leu Ala Arg Asp Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Lys Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Asn Asn Glu Asp Ile His 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Cys Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Val Asn Tyr Gly Asn 
    370                 375                 380                 


Trp Ser Lys Thr Val Ala Asp Leu Asn 
385                 390             


<210>  16
<211>  393
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  16

Met Leu Gln Arg Asn Ser Leu Lys Trp Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Asp Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Thr Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Val Pro His Ile Lys Pro Tyr Ala Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ser Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Ser Asp 
            100                 105                 110         


Lys Asn Met Val Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Asp Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Glu Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Ser Leu Ala Arg Glu Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Gln Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Asp Gln Asp Ile Asn 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Ser Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Thr Lys His Gly Asn 
    370                 375                 380                 


Trp Ser Arg Thr Val Ala Asp Leu Asn 
385                 390             


<210>  17
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Thr Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr 
1               5                   10                  15      


Gln His Ala Ser Lys Pro Lys Pro Asn Ser Glu Leu Val Phe Gly Lys 
            20                  25                  30          


Ser Phe Thr Asp His Met Leu Thr Val Glu Trp Thr Ala Glu Lys Gly 
        35                  40                  45              


Trp Gly Thr Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro 
    50                  55                  60                  


Ser Ala Val Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys 
65                  70                  75                  80  


Ala Tyr Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met 
                85                  90                  95      


Asn Met Lys Arg Met Asn Lys Ser Ala Gln Arg Ile Cys Leu Pro Thr 
            100                 105                 110         


Phe Asp Pro Glu Glu Leu Ile Thr Leu Ile Gly Lys Leu Ile Gln Gln 
        115                 120                 125             


Asp Lys Tyr Leu Val Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg 
    130                 135                 140                 


Pro Thr Leu Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp 
145                 150                 155                 160 


Arg Ala Leu Leu Tyr Val Ile Cys Cys Pro Val Gly Pro Tyr Tyr Lys 
                165                 170                 175     


Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg 
            180                 185                 190         


Ala Trp Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala 
        195                 200                 205             


Pro Cys Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln 
    210                 215                 220                 


Asn Leu Trp Leu Phe Gly Pro Asn Asn Asn Ile Thr Glu Val Gly Thr 
225                 230                 235                 240 


Met Asn Ala Phe Phe Val Phe Lys Asp Ser Lys Thr Gly Lys Lys Glu 
                245                 250                 255     


Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg 
            260                 265                 270         


Asp Ser Ile Leu Asn Leu Ala Lys Glu Arg Leu Glu Pro Ser Glu Trp 
        275                 280                 285             


Thr Ile Ser Glu Arg Tyr Phe Thr Ile Gly Glu Val Thr Glu Arg Ser 
    290                 295                 300                 


Lys Asn Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala Ile 
305                 310                 315                 320 


Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Gln Ile Asn Ile 
                325                 330                 335     


Pro Leu Leu Pro Gly Glu Gln Thr Gly Pro Leu Ala Lys Glu Val Ala 
            340                 345                 350         


Gln Trp Ile Asn Gly Ile Gln Tyr Gly Glu Thr Glu His Gly Asn Trp 
        355                 360                 365             


Ser Arg Val Val Thr Asp Leu Asn 
    370                 375     


<210>  18
<211>  376
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  18

Met Thr Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr 
1               5                   10                  15      


Gln His Ala Ser Lys Pro Lys Pro Asn Ser Glu Leu Val Phe Gly Lys 
            20                  25                  30          


Ser Phe Thr Asp His Met Leu Thr Ala Glu Trp Thr Ala Glu Lys Gly 
        35                  40                  45              


Trp Gly Thr Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro 
    50                  55                  60                  


Ser Ala Val Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys 
65                  70                  75                  80  


Ala Tyr Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met 
                85                  90                  95      


Asn Met Lys Arg Met Asn Lys Ser Ala Gln Arg Ile Cys Leu Pro Thr 
            100                 105                 110         


Phe Asp Pro Glu Glu Leu Ile Thr Leu Ile Gly Lys Leu Ile Gln Gln 
        115                 120                 125             


Asp Lys Tyr Leu Val Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg 
    130                 135                 140                 


Pro Thr Leu Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp 
145                 150                 155                 160 


Arg Ala Leu Leu Tyr Val Ile Cys Cys Pro Val Gly Pro Tyr Tyr Lys 
                165                 170                 175     


Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg 
            180                 185                 190         


Ala Trp Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala 
        195                 200                 205             


Pro Cys Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln 
    210                 215                 220                 


Asn Leu Trp Leu Phe Gly Pro Asn Asn Asn Ile Thr Glu Val Gly Thr 
225                 230                 235                 240 


Met Asn Ala Phe Phe Val Phe Lys Asp Ser Lys Thr Gly Lys Lys Glu 
                245                 250                 255     


Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg 
            260                 265                 270         


Asp Ser Ile Leu Asn Leu Ala Lys Glu Arg Leu Glu Pro Ser Glu Trp 
        275                 280                 285             


Thr Ile Ser Glu Arg Tyr Phe Thr Ile Gly Glu Val Thr Glu Arg Ser 
    290                 295                 300                 


Lys Asn Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Val Ile 
305                 310                 315                 320 


Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Gln Ile Asn Ile 
                325                 330                 335     


Pro Leu Leu Pro Gly Glu Gln Thr Gly Pro Leu Ala Lys Glu Val Ala 
            340                 345                 350         


Gln Trp Ile Asn Gly Ile Gln Tyr Gly Glu Thr Glu His Gly Asn Trp 
        355                 360                 365             


Ser Arg Val Val Thr Asp Leu Asn 
    370                 375     


<210>  19
<211>  374
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  19

Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr Glu His 
1               5                   10                  15      


Pro Ser Glu Pro Lys Pro Asn Asp Gln Leu Val Phe Gly Arg Ser Phe 
            20                  25                  30          


Thr Asp His Met Leu Thr Ala Glu Trp Thr Ala Ala Asn Gly Trp Asp 
        35                  40                  45              


Val Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro Ser Ala 
    50                  55                  60                  


Tyr Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys Ala Tyr 
65                  70                  75                  80  


Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met Asn Met 
                85                  90                  95      


Lys Arg Met Asn Lys Ser Ala Arg Arg Ile Cys Leu Pro Ala Phe Asp 
            100                 105                 110         


Ser Glu Glu Leu Ile Ala Leu Ile Ala Lys Leu Ile Gln Gln Asp Lys 
        115                 120                 125             


Arg Leu Ile Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg Pro Thr 
    130                 135                 140                 


Met Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp Arg Ala 
145                 150                 155                 160 


Leu Leu Tyr Val Ile Cys Ser Pro Val Gly Pro Tyr Tyr Lys Thr Gly 
                165                 170                 175     


Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg Ala Trp 
            180                 185                 190         


Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala Pro Cys 
        195                 200                 205             


Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln Asn Leu 
    210                 215                 220                 


Trp Leu Phe Gly Pro Glu Asn Asn Ile Thr Glu Val Gly Thr Met Asn 
225                 230                 235                 240 


Ala Phe Phe Val Phe Lys Asn Thr Glu Thr Gly Lys Lys Glu Leu Val 
                245                 250                 255     


Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg Asp Ser 
            260                 265                 270         


Ile Leu Thr Leu Ala Lys Glu Arg Leu Asp Leu Asn Glu Trp Thr Ile 
        275                 280                 285             


Ser Glu Arg Tyr Cys Thr Ile Gly Glu Val Ser Glu Arg Ser Lys Lys 
    290                 295                 300                 


Gly Glu Leu Val Glu Ala Phe Gly Ser Gly Thr Ala Ala Ile Val Ser 
305                 310                 315                 320 


Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Pro Ile Asn Ile Pro Leu 
                325                 330                 335     


Leu Pro Gly Glu Gln Thr Gly Pro Leu Thr Lys Glu Val Ala Gln Trp 
            340                 345                 350         


Ile Asn Gln Ile Gln Tyr Gly Glu Val Glu His Gly Asn Trp Ser Arg 
        355                 360                 365             


Val Ile Thr Asp Leu Asn 
    370                 


<210>  20
<211>  687
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Ile Arg Gln Ser Thr Leu Lys Asn Phe Ala Ile Lys Arg Cys Phe 
1               5                   10                  15      


Gln His Ile Ala Tyr Arg Asn Thr Pro Ala Met Arg Ser Val Ala Leu 
            20                  25                  30          


Ala Gln Arg Phe Tyr Ser Ser Ser Ser Arg Tyr Tyr Ser Ala Ser Pro 
        35                  40                  45              


Leu Pro Ala Ser Lys Arg Pro Glu Pro Ala Pro Ser Phe Asn Val Asp 
    50                  55                  60                  


Pro Leu Glu Gln Pro Ala Glu Pro Ser Lys Leu Ala Lys Lys Leu Arg 
65                  70                  75                  80  


Ala Glu Pro Asp Met Asp Thr Ser Phe Val Gly Leu Thr Gly Gly Gln 
                85                  90                  95      


Ile Phe Asn Glu Met Met Ser Arg Gln Asn Val Asp Thr Val Phe Gly 
            100                 105                 110         


Tyr Pro Gly Gly Ala Ile Leu Pro Val Tyr Asp Ala Ile His Asn Ser 
        115                 120                 125             


Asp Lys Phe Asn Phe Val Leu Pro Lys His Glu Gln Gly Ala Gly His 
    130                 135                 140                 


Met Ala Glu Gly Tyr Ala Arg Ala Ser Gly Lys Pro Gly Val Val Leu 
145                 150                 155                 160 


Val Thr Ser Gly Pro Gly Ala Thr Asn Val Val Thr Pro Met Ala Asp 
                165                 170                 175     


Ala Phe Ala Asp Gly Ile Pro Met Val Val Phe Thr Gly Gln Val Ser 
            180                 185                 190         


Thr Ser Ala Ile Gly Thr Asp Ala Phe Gln Glu Ala Asp Val Val Gly 
        195                 200                 205             


Ile Ser Arg Ser Cys Thr Lys Trp Asn Val Met Val Lys Ser Val Glu 
    210                 215                 220                 


Glu Leu Pro Leu Arg Ile Asn Glu Ala Phe Glu Ile Ala Thr Ser Gly 
225                 230                 235                 240 


Arg Pro Gly Pro Val Leu Val Asp Leu Pro Lys Asp Val Thr Ala Ala 
                245                 250                 255     


Ile Leu Arg Asn Pro Ile Pro Thr Lys Thr Thr Leu Pro Ser Asn Ala 
            260                 265                 270         


Leu Asn Gln Leu Thr Ser Arg Ala Gln Asp Glu Phe Val Met Gln Ser 
        275                 280                 285             


Ile Asn Lys Ala Ala Asp Leu Ile Asn Leu Ala Lys Lys Pro Val Leu 
    290                 295                 300                 


Tyr Val Gly Ala Gly Ile Leu Asn His Ala Asp Gly Pro Arg Leu Leu 
305                 310                 315                 320 


Lys Glu Leu Ser Asp Arg Ala Gln Ile Pro Val Thr Thr Thr Leu Gln 
                325                 330                 335     


Gly Leu Gly Ser Phe Asp Gln Glu Asp Pro Lys Ser Leu Asp Met Phe 
            340                 345                 350         


Gly Met His Gly Cys Ala Thr Ala Asn Leu Ala Val Gln Asn Ala Asp 
        355                 360                 365             


Leu Ile Ile Ala Val Gly Ala Arg Phe Asp Asp Arg Val Thr Gly Asn 
    370                 375                 380                 


Ile Ser Lys Phe Ala Pro Glu Ala Arg Arg Ala Ala Ala Glu Gly Arg 
385                 390                 395                 400 


Gly Gly Ile Ile His Phe Glu Val Ser Pro Lys Asn Ile Asn Lys Val 
                405                 410                 415     


Val Gln Thr Gln Ile Ala Val Glu Gly Asp Ala Thr Thr Asn Leu Gly 
            420                 425                 430         


Lys Met Met Ser Lys Ile Phe Pro Val Lys Glu Arg Ser Glu Trp Phe 
        435                 440                 445             


Ala Gln Ile Asn Lys Trp Lys Lys Glu Tyr Pro Tyr Ala Tyr Met Glu 
    450                 455                 460                 


Glu Thr Pro Gly Ser Lys Ile Lys Pro Gln Thr Val Ile Lys Lys Leu 
465                 470                 475                 480 


Ser Lys Val Ala Asn Asp Thr Gly Arg His Val Ile Val Thr Thr Gly 
                485                 490                 495     


Val Gly Gln His Gln Met Trp Ala Ala Gln His Trp Thr Trp Arg Asn 
            500                 505                 510         


Pro His Thr Phe Ile Thr Ser Gly Gly Leu Gly Thr Met Gly Tyr Gly 
        515                 520                 525             


Leu Pro Ala Ala Ile Gly Ala Gln Val Ala Lys Pro Glu Ser Leu Val 
    530                 535                 540                 


Ile Asp Ile Asp Gly Asp Ala Ser Phe Asn Met Thr Leu Thr Glu Leu 
545                 550                 555                 560 


Ser Ser Ala Val Gln Ala Gly Thr Pro Val Lys Ile Leu Ile Leu Asn 
                565                 570                 575     


Asn Glu Glu Gln Gly Met Val Thr Gln Trp Gln Ser Leu Phe Tyr Glu 
            580                 585                 590         


His Arg Tyr Ser His Thr His Gln Leu Asn Pro Asp Phe Ile Lys Leu 
        595                 600                 605             


Ala Glu Ala Met Gly Leu Lys Gly Leu Arg Val Lys Lys Gln Glu Glu 
    610                 615                 620                 


Leu Asp Ala Lys Leu Lys Glu Phe Val Ser Thr Lys Gly Pro Val Leu 
625                 630                 635                 640 


Leu Glu Val Glu Val Asp Lys Lys Val Pro Val Leu Pro Met Val Ala 
                645                 650                 655     


Gly Gly Ser Gly Leu Asp Glu Phe Ile Asn Phe Asp Pro Glu Val Glu 
            660                 665                 670         


Arg Gln Gln Thr Glu Leu Arg His Lys Arg Thr Gly Gly Lys His 
        675                 680                 685         


<210>  21
<211>  309
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Leu Arg Ser Leu Leu Gln Ser Gly His Arg Arg Val Val Ala Ser 
1               5                   10                  15      


Ser Cys Ala Thr Met Val Arg Cys Ser Ser Ser Ser Thr Ser Ala Leu 
            20                  25                  30          


Ala Tyr Lys Gln Met His Arg His Ala Thr Arg Pro Pro Leu Pro Thr 
        35                  40                  45              


Leu Asp Thr Pro Ser Trp Asn Ala Asn Ser Ala Val Ser Ser Ile Ile 
    50                  55                  60                  


Tyr Glu Thr Pro Ala Pro Ser Arg Gln Pro Arg Lys Gln His Val Leu 
65                  70                  75                  80  


Asn Cys Leu Val Gln Asn Glu Pro Gly Val Leu Ser Arg Val Ser Gly 
                85                  90                  95      


Thr Leu Ala Ala Arg Gly Phe Asn Ile Asp Ser Leu Val Val Cys Asn 
            100                 105                 110         


Thr Glu Val Lys Asp Leu Ser Arg Met Thr Ile Val Leu Gln Gly Gln 
        115                 120                 125             


Asp Gly Val Ile Glu Gln Ala Arg Arg Gln Ile Glu Asp Leu Val Pro 
    130                 135                 140                 


Val Tyr Ala Val Leu Asp Tyr Thr Asn Ser Glu Ile Val Lys Arg Glu 
145                 150                 155                 160 


Leu Val Met Ala Arg Ile Ser Leu Leu Gly Thr Glu Tyr Phe Glu Asp 
                165                 170                 175     


Leu Leu Leu His His His Thr Ser Thr Asn Ala Gly Ala Ala Asp Ser 
            180                 185                 190         


Gln Glu Leu Val Ala Glu Ile Arg Glu Lys Gln Phe His Pro Ala Asn 
        195                 200                 205             


Leu Pro Ala Ser Glu Val Leu Arg Leu Lys His Glu His Leu Asn Asp 
    210                 215                 220                 


Ile Thr Asn Leu Thr Asn Asn Phe Gly Gly Arg Val Val Asp Ile Ser 
225                 230                 235                 240 


Glu Thr Ser Cys Ile Val Glu Leu Ser Ala Lys Pro Thr Arg Ile Ser 
                245                 250                 255     


Ala Phe Leu Lys Leu Val Glu Pro Phe Gly Val Leu Glu Cys Ala Arg 
            260                 265                 270         


Ser Gly Met Met Ala Leu Pro Arg Thr Pro Leu Lys Thr Ser Thr Glu 
        275                 280                 285             


Glu Ala Ala Asp Glu Asp Glu Lys Ile Ser Glu Ile Val Asp Ile Ser 
    290                 295                 300                 


Gln Leu Pro Pro Gly 
305                 


<210>  22
<211>  309
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  22

Met Leu Arg Ser Leu Leu Gln Ser Gly His Arg Arg Val Ala Ala Ser 
1               5                   10                  15      


Ser Cys Ala Thr Met Val Arg Cys Ser Ser Ser Ser Thr Ser Ala Leu 
            20                  25                  30          


Ala Tyr Lys Gln Met His Arg His Ala Ala Arg Pro Pro Leu Pro Thr 
        35                  40                  45              


Leu Asp Thr Pro Ser Trp Asn Ala Asn Ser Ala Val Ser Ser Ile Ile 
    50                  55                  60                  


Tyr Glu Thr Pro Ala Pro Ser Arg Gln Pro Arg Lys Gln His Val Leu 
65                  70                  75                  80  


Asn Cys Leu Val Gln Asn Glu Pro Gly Val Leu Ser Arg Ile Ser Gly 
                85                  90                  95      


Thr Leu Ala Ala Arg Gly Phe Asn Ile Asp Ser Leu Val Val Cys Asn 
            100                 105                 110         


Thr Glu Val Lys Asp Leu Ser Arg Met Thr Ile Val Leu Gln Gly Gln 
        115                 120                 125             


Asp Gly Val Ile Glu Gln Ala Arg Arg Gln Ile Glu Asp Leu Val Pro 
    130                 135                 140                 


Val Tyr Ala Val Leu Asp Tyr Thr Asn Ser Glu Ile Ile Lys Arg Glu 
145                 150                 155                 160 


Leu Val Met Ala Arg Ile Ser Leu Leu Gly Thr Glu Tyr Phe Glu Asp 
                165                 170                 175     


Leu Leu Leu His His His Thr Ser Thr Ser Ser Gly Gly Ala Asp Ala 
            180                 185                 190         


Asn Glu Leu Val Ala Glu Ile Arg Glu Lys Gln Phe His Pro Ala Asn 
        195                 200                 205             


Leu Pro Ala Ser Glu Ile Leu Arg Leu Lys His Glu His Leu Asn Asp 
    210                 215                 220                 


Val Thr Asn Leu Thr Asn Asn Phe Gly Gly Arg Val Val Asp Ile Ser 
225                 230                 235                 240 


Glu Thr Ser Cys Ile Val Glu Leu Ser Ala Lys Pro Thr Arg Ile Ser 
                245                 250                 255     


Ala Phe Leu Lys Leu Val Glu Pro Phe Gly Val Leu Glu Cys Ala Arg 
            260                 265                 270         


Ser Gly Met Met Ala Leu Pro Arg Thr Pro Leu Lys Thr Ser Ile Glu 
        275                 280                 285             


Glu Ala Ala Asp Glu Asp Glu Lys Ile Asn Glu Ile Val Asp Ile Ser 
    290                 295                 300                 


Gln Leu Pro Pro Gly 
305                 


<210>  23
<211>  395
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Ile 
1               5                   10                  15      


Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr Ser 
            20                  25                  30          


Arg Pro Ala Ala Arg Phe Val Lys Pro Met Ile Thr Thr Arg Gly Leu 
        35                  40                  45              


Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr Glu Arg Ala 
    50                  55                  60                  


Asp Trp Pro Arg Glu Lys Leu Leu Asp Tyr Phe Lys Asn Asp Thr Phe 
65                  70                  75                  80  


Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr Gly Gln Gly Leu Asn Leu 
                85                  90                  95      


Arg Asp Asn Gly Leu Asn Val Ile Ile Gly Val Arg Lys Asp Gly Ala 
            100                 105                 110         


Ser Trp Lys Ala Ala Ile Glu Asp Gly Trp Val Pro Gly Lys Asn Leu 
        115                 120                 125             


Phe Thr Val Glu Asp Ala Ile Lys Arg Gly Cys Tyr Val Met Asn Leu 
    130                 135                 140                 


Leu Ser Asp Ala Ala Gln Ser Glu Thr Trp Pro Ala Ile Lys Pro Leu 
145                 150                 155                 160 


Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val 
                165                 170                 175     


Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp Val Ile 
            180                 185                 190         


Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg Ser Leu Phe Lys 
        195                 200                 205             


Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala Val Trp Asn Asp Val Thr 
    210                 215                 220                 


Gly Lys Ala His Glu Lys Ala Gln Ala Leu Ala Val Ala Ile Gly Ser 
225                 230                 235                 240 


Gly Tyr Val Tyr Gln Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 
                245                 250                 255     


Tyr Gly Glu Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 
            260                 265                 270         


Ala Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 
        275                 280                 285             


Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile 
    290                 295                 300                 


Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr Thr Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe Lys Asn Ala Leu Lys 
                325                 330                 335     


Pro Val Phe Gln Asp Leu Tyr Glu Ser Thr Lys Asn Gly Thr Glu Thr 
            340                 345                 350         


Lys Arg Ser Leu Glu Phe Asn Ser Gln Pro Asp Tyr Arg Glu Lys Leu 
        355                 360                 365             


Glu Lys Glu Leu Asp Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 
    370                 375                 380                 


Lys Glu Val Arg Lys Leu Arg Pro Glu Asn Gln 
385                 390                 395 


<210>  24
<211>  395
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  24

Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Val 
1               5                   10                  15      


Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr Ser 
            20                  25                  30          


Arg Pro Ala Ala Arg Phe Val Lys Pro Met Val Ala Thr Arg Gly Leu 
        35                  40                  45              


Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr Glu Arg Ala 
    50                  55                  60                  


Asp Trp Pro Arg Glu Lys Leu Leu Asn Tyr Phe Lys Asp Asp Thr Phe 
65                  70                  75                  80  


Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr Gly Gln Gly Leu Asn Leu 
                85                  90                  95      


Arg Asp Asn Gly Leu Asn Val Ile Ile Gly Val Arg Lys Asp Gly Ala 
            100                 105                 110         


Ser Trp Lys Ala Ala Ile Glu Asp Gly Trp Val Pro Gly Gln Asn Leu 
        115                 120                 125             


Phe Ser Val Glu Asp Ala Ile Lys Lys Gly Asn Tyr Val Met Asn Leu 
    130                 135                 140                 


Leu Ser Asp Ala Ala Gln Ser Glu Thr Trp Pro Thr Ile Lys Pro Leu 
145                 150                 155                 160 


Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val 
                165                 170                 175     


Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp Val Ile 
            180                 185                 190         


Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg Ser Leu Phe Lys 
        195                 200                 205             


Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala Val Trp Asn Asp Val Thr 
    210                 215                 220                 


Gly Lys Ala His Glu Lys Ala Gln Ala Leu Ala Val Ala Ile Gly Ser 
225                 230                 235                 240 


Gly Tyr Val Tyr Gln Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 
                245                 250                 255     


Tyr Gly Glu Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 
            260                 265                 270         


Ala Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 
        275                 280                 285             


Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile 
    290                 295                 300                 


Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr Thr Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe Lys Asn Ala Leu Lys 
                325                 330                 335     


Pro Val Phe Gln Asp Leu Tyr Glu Ser Thr Lys Asn Gly Thr Glu Thr 
            340                 345                 350         


Lys Arg Ser Leu Glu Phe Asn Ser Gln Pro Asp Tyr Arg Glu Lys Leu 
        355                 360                 365             


Glu Lys Glu Leu Val Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 
    370                 375                 380                 


Lys Glu Val Arg Lys Leu Arg Pro Glu Asn Lys 
385                 390                 395 


<210>  25
<211>  585
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Cys Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Glu Asp Phe Lys Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Glu Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Lys Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asp Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Ala Asn Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Arg 
            420                 425                 430         


Ala Arg Val Phe Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Arg 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Val Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Arg Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Val Ser 
    530                 535                 540                 


Asp Lys Glu Met Ala Gln Arg Lys Gln Ser Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Asn Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  26
<211>  585
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  26

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Ser Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Asp Asp Phe Gln Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Gln Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Thr Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asn Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Thr Ser Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Lys 
            420                 425                 430         


Ala Arg Val Tyr Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Lys 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Ile Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Lys Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Ile Ser 
    530                 535                 540                 


Glu Gln Glu Met Ser Gln Arg Lys Gln Asn Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Ser Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  27
<211>  585
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  27

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Ser Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Asp Asp Phe Gln Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Gln Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Thr Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asn Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Thr Ser Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Lys 
            420                 425                 430         


Ala Arg Val Tyr Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Lys 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Ile Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Lys Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Ile Ser 
    530                 535                 540                 


Glu Gln Glu Met Ser Gln Arg Lys Gln Asn Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Ser Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  28
<211>  393
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  28

Met Leu Gln Arg His Ser Leu Lys Leu Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Glu Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Ser Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Thr Pro His Ile Lys Pro Tyr Gly Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ala Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Pro Asp 
            100                 105                 110         


Lys Asn Met Ala Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Glu Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Gln Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Thr Leu Ala Arg Asp Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Lys Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Asn Asn Glu Asp Ile His 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Cys Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Val Asn Tyr Gly Asn 
    370                 375                 380                 


Trp Ser Lys Thr Val Ala Asp Leu Asn 
385                 390             


<210>  29
<211>  393
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  29

Met Leu Gln Arg Asn Ser Leu Lys Trp Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Asp Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Thr Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Val Pro His Ile Lys Pro Tyr Ala Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ser Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Ser Asp 
            100                 105                 110         


Lys Asn Met Val Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Asp Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Glu Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Ser Leu Ala Arg Glu Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Gln Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Asp Gln Asp Ile Asn 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Ser Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Thr Lys His Gly Asn 
    370                 375                 380                 


Trp Ser Arg Thr Val Ala Asp Leu Asn 
385                 390             


<210>  30
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  30

Met Thr Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr 
1               5                   10                  15      


Gln His Ala Ser Lys Pro Lys Pro Asn Ser Glu Leu Val Phe Gly Lys 
            20                  25                  30          


Ser Phe Thr Asp His Met Leu Thr Ala Glu Trp Thr Ala Glu Lys Gly 
        35                  40                  45              


Trp Gly Thr Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro 
    50                  55                  60                  


Ser Ala Val Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys 
65                  70                  75                  80  


Ala Tyr Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met 
                85                  90                  95      


Asn Met Lys Arg Met Asn Lys Ser Ala Gln Arg Ile Cys Leu Pro Thr 
            100                 105                 110         


Phe Asp Pro Glu Glu Leu Ile Thr Leu Ile Gly Lys Leu Ile Gln Gln 
        115                 120                 125             


Asp Lys Tyr Leu Val Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg 
    130                 135                 140                 


Pro Thr Leu Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp 
145                 150                 155                 160 


Arg Ala Leu Leu Tyr Val Ile Cys Cys Pro Val Gly Pro Tyr Tyr Lys 
                165                 170                 175     


Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg 
            180                 185                 190         


Ala Trp Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala 
        195                 200                 205             


Pro Cys Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln 
    210                 215                 220                 


Asn Leu Trp Leu Phe Gly Pro Asn Asn Asn Ile Thr Glu Val Gly Thr 
225                 230                 235                 240 


Met Asn Ala Phe Phe Val Phe Lys Asp Ser Lys Thr Gly Lys Lys Glu 
                245                 250                 255     


Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg 
            260                 265                 270         


Asp Ser Ile Leu Asn Leu Ala Lys Glu Arg Leu Glu Pro Ser Glu Trp 
        275                 280                 285             


Thr Ile Ser Glu Arg Tyr Phe Thr Ile Gly Glu Val Thr Glu Arg Ser 
    290                 295                 300                 


Lys Asn Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Val Ile 
305                 310                 315                 320 


Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Gln Ile Asn Ile 
                325                 330                 335     


Pro Leu Leu Pro Gly Glu Gln Thr Gly Pro Leu Ala Lys Glu Val Ala 
            340                 345                 350         


Gln Trp Ile Asn Gly Ile Gln Tyr Gly Glu Thr Glu His Gly Asn Trp 
        355                 360                 365             


Ser Arg Val Val Thr Asp Leu Asn 
    370                 375     


<210>  31
<211>  374
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  31

Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr Glu His 
1               5                   10                  15      


Pro Ser Glu Pro Lys Pro Asn Asp Gln Leu Val Phe Gly Arg Ser Phe 
            20                  25                  30          


Thr Asp His Met Leu Thr Ala Glu Trp Thr Ala Ala Asn Gly Trp Asp 
        35                  40                  45              


Val Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro Ser Ala 
    50                  55                  60                  


Tyr Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys Ala Tyr 
65                  70                  75                  80  


Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met Asn Met 
                85                  90                  95      


Lys Arg Met Asn Lys Ser Ala Arg Arg Ile Cys Leu Pro Ala Phe Asp 
            100                 105                 110         


Ser Glu Glu Leu Ile Ala Leu Ile Ala Lys Leu Ile Gln Gln Asp Lys 
        115                 120                 125             


Arg Leu Ile Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg Pro Thr 
    130                 135                 140                 


Met Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp Arg Ala 
145                 150                 155                 160 


Leu Leu Tyr Val Ile Cys Ser Pro Val Gly Pro Tyr Tyr Lys Thr Gly 
                165                 170                 175     


Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg Ala Trp 
            180                 185                 190         


Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala Pro Cys 
        195                 200                 205             


Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln Asn Leu 
    210                 215                 220                 


Trp Leu Phe Gly Pro Glu Asn Asn Ile Thr Glu Val Gly Thr Met Asn 
225                 230                 235                 240 


Ala Phe Phe Val Phe Lys Asn Thr Glu Thr Gly Lys Lys Glu Leu Val 
                245                 250                 255     


Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg Asp Ser 
            260                 265                 270         


Ile Leu Thr Leu Ala Lys Glu Arg Leu Asp Leu Asn Glu Trp Thr Ile 
        275                 280                 285             


Ser Glu Arg Tyr Cys Thr Ile Gly Glu Val Ser Glu Arg Ser Lys Lys 
    290                 295                 300                 


Gly Glu Leu Val Glu Ala Phe Gly Ser Gly Thr Ala Ala Ile Val Ser 
305                 310                 315                 320 


Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Pro Ile Asn Ile Pro Leu 
                325                 330                 335     


Leu Pro Gly Glu Gln Thr Gly Pro Leu Thr Lys Glu Val Ala Gln Trp 
            340                 345                 350         


Ile Asn Gln Ile Gln Tyr Gly Glu Val Glu His Gly Asn Trp Ser Arg 
        355                 360                 365             


Val Ile Thr Asp Leu Asn 
    370                 


<210>  32
<211>  687
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  32

Met Ile Arg Gln Ser Thr Leu Lys Asn Phe Ala Ile Lys Arg Cys Phe 
1               5                   10                  15      


Gln His Ile Ala Tyr Arg Asn Thr Pro Ala Met Arg Ser Val Ala Leu 
            20                  25                  30          


Ala Gln Arg Phe Tyr Ser Ser Ser Ser Arg Tyr Tyr Ser Ala Ser Pro 
        35                  40                  45              


Leu Pro Ala Ser Lys Arg Pro Glu Pro Ala Pro Ser Phe Asn Val Asp 
    50                  55                  60                  


Pro Leu Glu Gln Pro Ala Glu Pro Ser Lys Leu Ala Lys Lys Leu Arg 
65                  70                  75                  80  


Ala Glu Pro Asp Met Asp Thr Ser Phe Val Gly Leu Thr Gly Gly Gln 
                85                  90                  95      


Ile Phe Asn Glu Met Met Ser Arg Gln Asn Val Asp Thr Val Phe Gly 
            100                 105                 110         


Tyr Pro Gly Gly Ala Ile Leu Pro Val Tyr Asp Ala Ile His Asn Ser 
        115                 120                 125             


Asp Lys Phe Asn Phe Val Leu Pro Lys His Glu Gln Gly Ala Gly His 
    130                 135                 140                 


Met Ala Glu Gly Tyr Ala Arg Ala Ser Gly Lys Pro Gly Val Val Leu 
145                 150                 155                 160 


Val Thr Ser Gly Pro Gly Ala Thr Asn Val Val Thr Pro Met Ala Asp 
                165                 170                 175     


Ala Phe Ala Asp Gly Ile Pro Met Val Val Phe Thr Gly Gln Val Pro 
            180                 185                 190         


Thr Ser Ala Ile Gly Thr Asp Ala Phe Gln Glu Ala Asp Val Val Gly 
        195                 200                 205             


Ile Ser Arg Ser Cys Thr Lys Trp Asn Val Met Val Lys Ser Val Glu 
    210                 215                 220                 


Glu Leu Pro Leu Arg Ile Asn Glu Ala Phe Glu Ile Ala Thr Ser Gly 
225                 230                 235                 240 


Arg Pro Gly Pro Val Leu Val Asp Leu Pro Lys Asp Val Thr Ala Ala 
                245                 250                 255     


Ile Leu Arg Asn Pro Ile Pro Thr Lys Thr Thr Leu Pro Ser Asn Ala 
            260                 265                 270         


Leu Asn Gln Leu Thr Ser Arg Ala Gln Asp Glu Phe Val Met Gln Ser 
        275                 280                 285             


Ile Asn Lys Ala Ala Asp Leu Ile Asn Leu Ala Lys Lys Pro Val Leu 
    290                 295                 300                 


Tyr Val Gly Ala Gly Ile Leu Asn His Ala Asp Gly Pro Arg Leu Leu 
305                 310                 315                 320 


Lys Glu Leu Ser Asp Arg Ala Gln Ile Pro Val Thr Thr Thr Leu Gln 
                325                 330                 335     


Gly Leu Gly Ser Phe Asp Gln Glu Asp Pro Lys Ser Leu Asp Met Leu 
            340                 345                 350         


Gly Met His Gly Cys Ala Thr Ala Asn Leu Ala Val Gln Asn Ala Asp 
        355                 360                 365             


Leu Ile Ile Ala Val Gly Ala Arg Phe Asp Asp Arg Val Thr Gly Asn 
    370                 375                 380                 


Ile Ser Lys Phe Ala Pro Glu Ala Arg Arg Ala Ala Ala Glu Gly Arg 
385                 390                 395                 400 


Gly Gly Ile Ile His Phe Glu Val Ser Pro Lys Asn Ile Asn Lys Val 
                405                 410                 415     


Val Gln Thr Gln Ile Ala Val Glu Gly Asp Ala Thr Thr Asn Leu Gly 
            420                 425                 430         


Lys Met Met Ser Lys Ile Phe Pro Val Lys Glu Arg Ser Glu Trp Phe 
        435                 440                 445             


Ala Gln Ile Asn Lys Trp Lys Lys Glu Tyr Pro Tyr Ala Tyr Met Glu 
    450                 455                 460                 


Glu Thr Pro Gly Ser Lys Ile Lys Pro Gln Thr Val Ile Lys Lys Leu 
465                 470                 475                 480 


Ser Lys Val Ala Asn Asp Thr Gly Arg His Val Ile Val Thr Thr Gly 
                485                 490                 495     


Val Gly Gln His Gln Met Trp Ala Ala Gln His Trp Thr Trp Arg Asn 
            500                 505                 510         


Pro His Thr Phe Ile Thr Ser Gly Gly Leu Gly Thr Met Gly Tyr Gly 
        515                 520                 525             


Leu Pro Ala Ala Ile Gly Ala Gln Val Ala Lys Pro Glu Ser Leu Val 
    530                 535                 540                 


Ile Asp Ile Asp Gly Asp Ala Ser Phe Asn Met Thr Leu Thr Glu Leu 
545                 550                 555                 560 


Ser Ser Ala Val Gln Ala Gly Thr Pro Val Lys Ile Leu Ile Leu Asn 
                565                 570                 575     


Asn Glu Glu Gln Gly Met Val Thr Gln Trp Gln Ser Leu Phe Tyr Glu 
            580                 585                 590         


His Arg Tyr Ser His Thr His Gln Leu Asn Pro Asp Phe Ile Lys Leu 
        595                 600                 605             


Ala Glu Ala Met Gly Leu Lys Gly Leu Arg Val Lys Lys Gln Glu Glu 
    610                 615                 620                 


Leu Asp Ala Lys Leu Lys Glu Phe Val Ser Thr Lys Gly Pro Val Leu 
625                 630                 635                 640 


Leu Glu Val Glu Val Asp Lys Lys Val Pro Val Leu Pro Met Val Ala 
                645                 650                 655     


Gly Gly Ser Gly Leu Asp Glu Phe Ile Asn Phe Asp Pro Glu Val Glu 
            660                 665                 670         


Arg Gln Gln Thr Glu Leu Arg His Lys Arg Thr Gly Gly Lys His 
        675                 680                 685         


<210>  33
<211>  309
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Leu Arg Ser Leu Leu Gln Ser Gly His Arg Arg Val Val Ala Ser 
1               5                   10                  15      


Ser Cys Ala Thr Met Val Arg Cys Ser Ser Ser Ser Thr Ser Ala Leu 
            20                  25                  30          


Ala Tyr Lys Gln Met His Arg His Ala Thr Arg Pro Pro Leu Pro Thr 
        35                  40                  45              


Leu Asp Thr Pro Ser Trp Asn Ala Asn Ser Ala Val Ser Ser Ile Ile 
    50                  55                  60                  


Tyr Glu Thr Pro Ala Pro Ser Arg Gln Pro Arg Lys Gln His Val Leu 
65                  70                  75                  80  


Asn Cys Leu Val Gln Asn Glu Pro Gly Val Leu Ser Arg Val Ser Gly 
                85                  90                  95      


Thr Leu Ala Ala Arg Gly Phe Asn Ile Asp Ser Leu Val Val Cys Asn 
            100                 105                 110         


Thr Glu Val Lys Asp Leu Ser Arg Met Thr Ile Val Leu Gln Gly Gln 
        115                 120                 125             


Asp Gly Val Val Glu Gln Ala Arg Arg Gln Ile Glu Asp Leu Val Pro 
    130                 135                 140                 


Val Tyr Ala Val Leu Asp Tyr Thr Asn Ser Glu Ile Ile Lys Arg Glu 
145                 150                 155                 160 


Leu Val Met Ala Arg Ile Ser Leu Leu Gly Thr Glu Tyr Phe Glu Asp 
                165                 170                 175     


Leu Leu Leu His His His Thr Ser Thr Asn Ala Gly Ala Ala Asp Ser 
            180                 185                 190         


Gln Glu Leu Val Ala Glu Ile Arg Glu Lys Gln Phe His Pro Ala Asn 
        195                 200                 205             


Leu Pro Ala Ser Glu Val Leu Arg Leu Lys His Glu His Leu Asn Asp 
    210                 215                 220                 


Ile Thr Asn Leu Thr Asn Asn Phe Gly Gly Arg Val Val Asp Ile Ser 
225                 230                 235                 240 


Glu Thr Ser Cys Ile Val Glu Leu Ser Ala Lys Pro Thr Arg Ile Ser 
                245                 250                 255     


Ala Phe Leu Lys Leu Val Glu Pro Phe Gly Val Leu Glu Cys Ala Arg 
            260                 265                 270         


Ser Gly Met Met Ala Leu Pro Arg Thr Pro Leu Lys Thr Ser Thr Glu 
        275                 280                 285             


Glu Ala Ala Asp Glu Asp Glu Lys Ile Ser Glu Ile Val Asp Ile Ser 
    290                 295                 300                 


Gln Leu Pro Pro Gly 
305                 


<210>  34
<211>  395
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  34

Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Ile 
1               5                   10                  15      


Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr Ser 
            20                  25                  30          


Arg Pro Ala Ala Arg Phe Val Lys Pro Met Ile Thr Thr Arg Gly Leu 
        35                  40                  45              


Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr Glu Arg Ala 
    50                  55                  60                  


Asp Trp Pro Arg Glu Lys Leu Leu Asp Tyr Phe Lys Asn Asp Thr Phe 
65                  70                  75                  80  


Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr Gly Gln Gly Leu Asn Leu 
                85                  90                  95      


Arg Asp Asn Gly Leu Asn Val Ile Ile Gly Val Arg Lys Asp Gly Ala 
            100                 105                 110         


Ser Trp Lys Ala Ala Ile Glu Asp Gly Trp Val Pro Gly Lys Asn Leu 
        115                 120                 125             


Phe Thr Val Glu Asp Ala Ile Lys Arg Gly Ser Tyr Val Met Asn Leu 
    130                 135                 140                 


Leu Ser Asp Ala Ala Gln Ser Glu Thr Trp Pro Ala Ile Lys Pro Leu 
145                 150                 155                 160 


Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val 
                165                 170                 175     


Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp Val Ile 
            180                 185                 190         


Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg Ser Leu Phe Lys 
        195                 200                 205             


Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala Val Trp Asn Asp Val Thr 
    210                 215                 220                 


Gly Lys Ala His Glu Lys Ala Gln Ala Leu Ala Val Ala Ile Gly Ser 
225                 230                 235                 240 


Gly Tyr Val Tyr Gln Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 
                245                 250                 255     


Tyr Gly Glu Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 
            260                 265                 270         


Ala Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 
        275                 280                 285             


Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile 
    290                 295                 300                 


Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr Thr Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe Lys Asn Ala Leu Lys 
                325                 330                 335     


Pro Val Phe Gln Asp Leu Tyr Glu Ser Thr Lys Asn Gly Thr Glu Thr 
            340                 345                 350         


Lys Arg Ser Leu Glu Phe Asn Ser Gln Pro Asp Tyr Arg Glu Lys Leu 
        355                 360                 365             


Glu Lys Glu Leu Asp Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 
    370                 375                 380                 


Lys Glu Val Arg Lys Leu Arg Pro Glu Asn Gln 
385                 390                 395 


<210>  35
<211>  585
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  35

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Cys Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Glu Asp Phe Lys Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Glu Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Lys Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asp Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Ala Asn Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Arg 
            420                 425                 430         


Ala Arg Val Phe Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Arg 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Val Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Arg Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Val Ser 
    530                 535                 540                 


Asp Lys Glu Met Ala Gln Arg Lys Gln Ser Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Asn Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  36
<211>  393
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  36

Met Leu Gln Arg His Ser Leu Lys Leu Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Glu Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Ser Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Thr Pro His Ile Lys Pro Tyr Gly Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ala Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Pro Asp 
            100                 105                 110         


Lys Asn Met Ala Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Glu Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Gln Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Thr Leu Ala Arg Asp Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Lys Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Asn Asn Glu Asp Ile His 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Cys Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Val Asn Tyr Gly Asn 
    370                 375                 380                 


Trp Ser Lys Thr Val Ala Asp Leu Asn 
385                 390             


<210>  37
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  37

Met Thr Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr 
1               5                   10                  15      


Gln His Ala Ser Lys Pro Lys Pro Asn Ser Glu Leu Val Phe Gly Lys 
            20                  25                  30          


Ser Phe Thr Asp His Met Leu Thr Val Glu Trp Thr Ala Glu Lys Gly 
        35                  40                  45              


Trp Gly Thr Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro 
    50                  55                  60                  


Ser Ala Val Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys 
65                  70                  75                  80  


Ala Tyr Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met 
                85                  90                  95      


Asn Met Lys Arg Met Asn Lys Ser Ala Gln Arg Ile Cys Leu Pro Thr 
            100                 105                 110         


Phe Asp Pro Glu Glu Leu Ile Thr Leu Ile Gly Lys Leu Ile Gln Gln 
        115                 120                 125             


Asp Lys Tyr Leu Val Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg 
    130                 135                 140                 


Pro Thr Leu Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp 
145                 150                 155                 160 


Arg Ala Leu Leu Tyr Val Ile Cys Cys Pro Val Gly Pro Tyr Tyr Lys 
                165                 170                 175     


Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg 
            180                 185                 190         


Ala Trp Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala 
        195                 200                 205             


Pro Cys Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln 
    210                 215                 220                 


Asn Leu Trp Leu Phe Gly Pro Asn Asn Asn Ile Thr Glu Val Gly Thr 
225                 230                 235                 240 


Met Asn Ala Phe Phe Val Phe Lys Asp Ser Lys Thr Gly Lys Lys Glu 
                245                 250                 255     


Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg 
            260                 265                 270         


Asp Ser Ile Leu Asn Leu Ala Lys Glu Arg Leu Glu Pro Ser Glu Trp 
        275                 280                 285             


Thr Ile Ser Glu Arg Tyr Phe Thr Ile Gly Glu Val Thr Glu Arg Ser 
    290                 295                 300                 


Lys Asn Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala Ile 
305                 310                 315                 320 


Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Gln Ile Asn Ile 
                325                 330                 335     


Pro Leu Leu Pro Gly Glu Gln Thr Gly Pro Leu Ala Lys Glu Val Ala 
            340                 345                 350         


Gln Trp Ile Asn Gly Ile Gln Tyr Gly Glu Thr Glu His Gly Asn Trp 
        355                 360                 365             


Ser Arg Val Val Thr Asp Leu Asn 
    370                 375     


<210>  38
<211>  687
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  38

Met Ile Arg Gln Ser Thr Leu Lys Asn Phe Ala Ile Lys Arg Cys Phe 
1               5                   10                  15      


Gln Gln Met Ala Tyr Arg Asn Thr Pro Ala Met Arg Ser Val Ala Leu 
            20                  25                  30          


Ala Gln Arg Phe Tyr Ser Ser Ser Ser Arg Tyr Tyr Ser Ala Ser Pro 
        35                  40                  45              


Leu Pro Ala Ser Asn Arg Pro Glu Pro Ala Pro Ser Phe Asn Val Glu 
    50                  55                  60                  


Pro Val Ala Gln Val Pro Glu Pro Ser Lys Leu Ala Lys Arg Leu Arg 
65                  70                  75                  80  


Thr Glu Pro Asp Met Asp Thr Ser Phe Val Gly Leu Thr Gly Gly Gln 
                85                  90                  95      


Ile Phe Asn Glu Met Met Ser Arg His Asn Val Asp Thr Val Phe Gly 
            100                 105                 110         


Tyr Pro Gly Gly Ala Ile Leu Pro Val Tyr Asp Ala Ile His Asn Ser 
        115                 120                 125             


Asp Lys Phe Thr Phe Val Leu Pro Arg His Glu Gln Gly Ala Gly His 
    130                 135                 140                 


Met Ala Glu Gly Tyr Ala Arg Ala Ser Gly Lys Pro Gly Val Val Leu 
145                 150                 155                 160 


Val Thr Ser Gly Pro Gly Ala Thr Asn Val Ile Thr Pro Met Ala Asp 
                165                 170                 175     


Ala Phe Ala Asp Gly Ile Pro Met Val Val Phe Thr Gly Gln Val Pro 
            180                 185                 190         


Thr Ser Ala Ile Gly Thr Asp Ala Phe Gln Glu Ala Asp Val Val Gly 
        195                 200                 205             


Ile Ser Arg Ser Cys Thr Lys Trp Asn Val Met Val Lys Thr Val Glu 
    210                 215                 220                 


Glu Leu Pro Leu Arg Ile Asn Glu Ala Phe Glu Ile Ala Thr Ser Gly 
225                 230                 235                 240 


Arg Pro Gly Pro Val Leu Val Asp Leu Pro Lys Asp Val Thr Ala Ala 
                245                 250                 255     


Ile Leu Arg Asn Pro Ile Pro Thr Lys Thr Thr Leu Pro Ser Asn Ala 
            260                 265                 270         


Leu Asn Gln Leu Thr Ser Arg Thr Gln Asp Glu Phe Val Leu Gln Asn 
        275                 280                 285             


Ile Asn Arg Ala Ala Asp Leu Ile Asn Leu Ala Lys Lys Pro Val Leu 
    290                 295                 300                 


Tyr Val Gly Ala Gly Ile Leu Asn His Ala Asp Gly Pro Arg Leu Leu 
305                 310                 315                 320 


Lys Glu Leu Ser Asp Arg Ala Gln Ile Pro Val Thr Thr Thr Leu Gln 
                325                 330                 335     


Gly Leu Gly Ala Phe Asp Gln Asp Asp Pro Lys Ser Leu Asp Met Leu 
            340                 345                 350         


Gly Met His Gly Cys Ala Thr Ala Asn Leu Ala Val Gln Asn Ala Asp 
        355                 360                 365             


Leu Leu Ile Ala Val Gly Ala Arg Phe Asp Asp Arg Val Thr Leu Asn 
    370                 375                 380                 


Ile Ala Lys Phe Ala Pro Glu Ala Arg Arg Ala Ala Ala Glu Gly Arg 
385                 390                 395                 400 


Gly Gly Ile Ile His Phe Glu Val Ser Pro Lys Asn Ile Asn Lys Val 
                405                 410                 415     


Val Glu Thr Gln Ile Ala Val Glu Gly Asp Ala Thr Gly Asn Leu Asp 
            420                 425                 430         


Lys Met Met Pro Lys Ile Phe Pro Val Lys Glu Arg Ser Glu Trp Phe 
        435                 440                 445             


Gly Gln Ile Asn Glu Trp Lys Lys Lys Tyr Pro Tyr Ala Tyr Met Met 
    450                 455                 460                 


Glu Thr Pro Gly Ser Lys Ile Lys Pro Gln Thr Val Ile Thr Lys Leu 
465                 470                 475                 480 


Ser Lys Ile Ala Asn Asp Thr Gly Arg His Val Ile Val Thr Thr Gly 
                485                 490                 495     


Val Gly Gln His Gln Met Trp Ala Ala Gln His Trp Thr Trp Lys Thr 
            500                 505                 510         


Pro Arg Thr Phe Ile Thr Ser Gly Gly Leu Gly Thr Met Gly Tyr Gly 
        515                 520                 525             


Leu Pro Ala Ala Ile Gly Ala Gln Val Ala Lys Pro Asp Ser Leu Val 
    530                 535                 540                 


Ile Asp Ile Asp Gly Asp Ala Ser Phe Asn Met Thr Leu Thr Glu Leu 
545                 550                 555                 560 


Ser Ser Ala Val Gln Ala Gly Thr Pro Val Lys Ile Leu Val Leu Asn 
                565                 570                 575     


Asn Glu Glu Gln Gly Met Val Thr Gln Trp Gln Ser Leu Phe Tyr Glu 
            580                 585                 590         


Asn Arg Tyr Ser His Thr His Gln Leu Asn Pro Asp Phe Ile Lys Leu 
        595                 600                 605             


Ala Asp Ala Met Gly Leu Lys Gly Leu Arg Val Lys Lys Gln Glu Glu 
    610                 615                 620                 


Leu Asp Ala Lys Leu Lys Glu Phe Val Ser Thr Lys Gly Pro Val Leu 
625                 630                 635                 640 


Leu Glu Val Glu Val Asp Lys Lys Val Pro Val Leu Pro Met Val Pro 
                645                 650                 655     


Ala Gly Lys Gly Leu Asp Glu Phe Ile Tyr Phe Asp Pro Glu Val Glu 
            660                 665                 670         


Arg Gln Gln Asn Glu Leu Arg His Lys Arg Thr Asn Gly Lys His 
        675                 680                 685         


<210>  39
<211>  309
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  39

Met Leu Arg Ser Leu Leu Gln Ser Gly His Arg Arg Val Ala Ala Ser 
1               5                   10                  15      


Ser Cys Ala Thr Met Val Arg Cys Ser Ser Ser Ser Thr Ser Ala Leu 
            20                  25                  30          


Ala Tyr Lys Gln Met His Arg His Ala Ala Arg Pro Pro Leu Pro Thr 
        35                  40                  45              


Leu Asp Thr Pro Ser Trp Asn Ala Asn Ser Ala Val Ser Ser Ile Ile 
    50                  55                  60                  


Tyr Glu Thr Pro Ala Pro Ser Arg Gln Pro Arg Lys Gln His Val Leu 
65                  70                  75                  80  


Asn Cys Leu Val Gln Asn Glu Pro Gly Val Leu Ser Arg Ile Ser Gly 
                85                  90                  95      


Thr Leu Ala Ala Arg Gly Phe Asn Ile Asp Ser Leu Val Val Cys Asn 
            100                 105                 110         


Thr Glu Val Lys Asp Leu Ser Arg Met Thr Ile Val Leu Gln Gly Gln 
        115                 120                 125             


Asp Gly Val Ile Glu Gln Ala Arg Arg Gln Ile Glu Asp Leu Val Pro 
    130                 135                 140                 


Val Tyr Ala Val Leu Asp Tyr Thr Asn Ser Glu Ile Ile Lys Arg Glu 
145                 150                 155                 160 


Leu Val Met Ala Arg Ile Ser Leu Leu Gly Thr Glu Tyr Phe Glu Asp 
                165                 170                 175     


Leu Leu Leu His His His Thr Ser Thr Ser Ser Gly Gly Ala Asp Ala 
            180                 185                 190         


Asn Glu Leu Val Ala Glu Ile Arg Glu Lys Gln Phe His Pro Ala Asn 
        195                 200                 205             


Leu Pro Ala Ser Glu Ile Leu Arg Leu Lys His Glu His Leu Asn Asp 
    210                 215                 220                 


Val Thr Asn Leu Thr Asn Asn Phe Gly Gly Arg Val Val Asp Ile Ser 
225                 230                 235                 240 


Glu Thr Ser Cys Ile Val Glu Leu Ser Ala Lys Pro Thr Arg Ile Ser 
                245                 250                 255     


Ala Phe Leu Lys Leu Val Glu Pro Phe Gly Val Leu Glu Cys Ala Arg 
            260                 265                 270         


Ser Gly Met Met Ala Leu Pro Arg Thr Pro Leu Lys Thr Ser Ile Glu 
        275                 280                 285             


Glu Ala Ala Asp Glu Asp Glu Lys Ile Asn Glu Ile Val Asp Ile Ser 
    290                 295                 300                 


Gln Leu Pro Pro Gly 
305                 


<210>  40
<211>  395
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  40

Met Leu Arg Thr Gln Ala Ala Arg Leu Ile Cys Asn Ser Arg Val Val 
1               5                   10                  15      


Thr Ala Lys Arg Thr Phe Ala Leu Ala Thr Arg Ala Ala Ala Tyr Ser 
            20                  25                  30          


Arg Pro Ala Ala Arg Phe Val Lys Pro Met Val Ala Thr Arg Gly Leu 
        35                  40                  45              


Lys Gln Ile Asn Phe Gly Gly Thr Val Glu Thr Val Tyr Glu Arg Ala 
    50                  55                  60                  


Asp Trp Pro Arg Glu Lys Leu Leu Asn Tyr Phe Lys Asp Asp Thr Phe 
65                  70                  75                  80  


Ala Leu Ile Gly Tyr Gly Ser Gln Gly Tyr Gly Gln Gly Leu Asn Leu 
                85                  90                  95      


Arg Asp Asn Gly Leu Asn Val Ile Ile Gly Val Arg Lys Asp Gly Ala 
            100                 105                 110         


Ser Trp Lys Ala Ala Ile Glu Asp Gly Trp Val Pro Gly Gln Asn Leu 
        115                 120                 125             


Phe Ser Val Glu Asp Ala Ile Lys Lys Gly Asn Tyr Val Met Asn Leu 
    130                 135                 140                 


Leu Ser Asp Ala Ala Gln Ser Glu Thr Trp Pro Thr Ile Lys Pro Leu 
145                 150                 155                 160 


Leu Thr Lys Gly Lys Thr Leu Tyr Phe Ser His Gly Phe Ser Pro Val 
                165                 170                 175     


Phe Lys Asp Leu Thr His Val Glu Pro Pro Lys Asp Leu Asp Val Ile 
            180                 185                 190         


Leu Val Ala Pro Lys Gly Ser Gly Arg Thr Val Arg Ser Leu Phe Lys 
        195                 200                 205             


Glu Gly Arg Gly Ile Asn Ser Ser Tyr Ala Val Trp Asn Asp Val Thr 
    210                 215                 220                 


Gly Lys Ala His Glu Lys Ala Gln Ala Leu Ala Val Ala Ile Gly Ser 
225                 230                 235                 240 


Gly Tyr Val Tyr Gln Thr Thr Phe Glu Arg Glu Val Asn Ser Asp Leu 
                245                 250                 255     


Tyr Gly Glu Arg Gly Cys Leu Met Gly Gly Ile His Gly Met Phe Leu 
            260                 265                 270         


Ala Gln Tyr Asp Val Leu Arg Glu Asn Gly His Ser Pro Ser Glu Ala 
        275                 280                 285             


Phe Asn Glu Thr Val Glu Glu Ala Thr Gln Ser Leu Tyr Pro Leu Ile 
    290                 295                 300                 


Gly Lys Tyr Gly Met Asp Tyr Met Tyr Asp Ala Cys Ser Thr Thr Ala 
305                 310                 315                 320 


Arg Arg Gly Ala Leu Asp Trp Tyr Pro Ile Phe Lys Asn Ala Leu Lys 
                325                 330                 335     


Pro Val Phe Gln Asp Leu Tyr Glu Ser Thr Lys Asn Gly Thr Glu Thr 
            340                 345                 350         


Lys Arg Ser Leu Glu Phe Asn Ser Gln Pro Asp Tyr Arg Glu Lys Leu 
        355                 360                 365             


Glu Lys Glu Leu Val Thr Ile Arg Asn Met Glu Ile Trp Lys Val Gly 
    370                 375                 380                 


Lys Glu Val Arg Lys Leu Arg Pro Glu Asn Lys 
385                 390                 395 


<210>  41
<211>  585
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  41

Met Gly Leu Leu Thr Lys Val Ala Thr Ser Arg Gln Phe Ser Thr Thr 
1               5                   10                  15      


Arg Ser Val Ala Lys Lys Leu Asn Lys Tyr Ser Tyr Ile Ile Thr Glu 
            20                  25                  30          


Pro Lys Gly Gln Gly Ala Ser Gln Ala Met Leu Tyr Ala Thr Gly Phe 
        35                  40                  45              


Lys Lys Asp Asp Phe Gln Lys Pro Gln Val Gly Val Gly Ser Cys Trp 
    50                  55                  60                  


Trp Ser Gly Asn Pro Cys Asn Met His Leu Leu Asp Leu Asn Asn Arg 
65                  70                  75                  80  


Cys Ser Gln Ser Ile Glu Lys Ala Gly Leu Lys Ala Met Gln Phe Asn 
                85                  90                  95      


Thr Ile Gly Val Ser Asp Gly Ile Ser Met Gly Thr Lys Gly Met Arg 
            100                 105                 110         


Tyr Ser Leu Gln Ser Arg Glu Ile Ile Ala Asp Ser Phe Glu Thr Ile 
        115                 120                 125             


Met Met Ala Gln His Tyr Asp Ala Asn Ile Ala Ile Pro Ser Cys Asp 
    130                 135                 140                 


Lys Asn Met Pro Gly Val Met Met Ala Met Gly Arg His Asn Arg Pro 
145                 150                 155                 160 


Ser Ile Met Val Tyr Gly Gly Thr Ile Leu Pro Gly His Pro Thr Cys 
                165                 170                 175     


Gly Ser Ser Lys Ile Ser Lys Asn Ile Asp Ile Val Ser Ala Phe Gln 
            180                 185                 190         


Ser Tyr Gly Glu Tyr Ile Ser Lys Gln Phe Thr Glu Glu Glu Arg Glu 
        195                 200                 205             


Asp Val Val Glu His Ala Cys Pro Gly Pro Gly Ser Cys Gly Gly Met 
    210                 215                 220                 


Tyr Thr Ala Asn Thr Met Ala Ser Ala Ala Glu Val Leu Gly Leu Thr 
225                 230                 235                 240 


Ile Pro Asn Ser Ser Ser Phe Pro Ala Val Ser Lys Gln Lys Leu Ala 
                245                 250                 255     


Glu Cys Asp Asn Ile Gly Glu Tyr Ile Lys Thr Thr Met Glu Leu Gly 
            260                 265                 270         


Ile Leu Pro Arg Asp Ile Leu Thr Lys Glu Ala Phe Glu Asn Ala Ile 
        275                 280                 285             


Thr Tyr Val Val Ala Thr Gly Gly Ser Thr Asn Ala Val Leu His Leu 
    290                 295                 300                 


Val Ala Val Ala His Ser Ala Gly Val Lys Leu Ser Pro Asp Asp Phe 
305                 310                 315                 320 


Gln Arg Ile Ser Asn Thr Thr Pro Leu Ile Gly Asp Phe Lys Pro Ser 
                325                 330                 335     


Gly Lys Tyr Val Met Ala Asp Leu Ile Asn Val Gly Gly Thr Gln Ser 
            340                 345                 350         


Val Ile Lys Tyr Leu Tyr Glu Asn Asn Met Leu His Gly Asn Thr Met 
        355                 360                 365             


Thr Val Thr Gly Asp Thr Leu Ala Glu Arg Ala Lys Lys Ala Pro Ser 
    370                 375                 380                 


Leu Pro Glu Gly Gln Glu Ile Ile Lys Pro Leu Ser His Pro Ile Lys 
385                 390                 395                 400 


Thr Ser Gly His Leu Gln Ile Leu Tyr Gly Ser Leu Ala Pro Gly Gly 
                405                 410                 415     


Ala Val Gly Lys Ile Thr Gly Lys Glu Gly Thr Tyr Phe Lys Gly Lys 
            420                 425                 430         


Ala Arg Val Tyr Glu Glu Glu Gly Ala Phe Ile Glu Ala Leu Glu Lys 
        435                 440                 445             


Gly Glu Ile Lys Lys Gly Glu Lys Thr Val Val Ile Ile Arg Tyr Glu 
    450                 455                 460                 


Gly Pro Arg Gly Ala Pro Gly Met Pro Glu Met Leu Lys Pro Ser Ser 
465                 470                 475                 480 


Ala Leu Met Gly Tyr Gly Leu Gly Lys Asp Val Ala Leu Leu Thr Asp 
                485                 490                 495     


Gly Arg Phe Ser Gly Gly Ser His Gly Phe Leu Ile Gly His Ile Val 
            500                 505                 510         


Pro Glu Ala Ala Glu Gly Gly Pro Ile Gly Leu Val Lys Asp Gly Asp 
        515                 520                 525             


Glu Ile Ile Ile Asp Ala Asp Asn Asn Lys Ile Asp Leu Leu Ile Ser 
    530                 535                 540                 


Glu Gln Glu Met Ser Gln Arg Lys Gln Asn Trp Val Ala Pro Pro Pro 
545                 550                 555                 560 


Arg Tyr Thr Arg Gly Thr Leu Ser Lys Tyr Ala Lys Leu Val Ser Asn 
                565                 570                 575     


Ala Ser Ser Gly Cys Val Leu Asp Ala 
            580                 585 


<210>  42
<211>  393
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  42

Met Leu Gln Arg Asn Ser Leu Lys Leu Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Asp Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Thr Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Val Pro His Ile Lys Pro Tyr Ala Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ser Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Ser Asp 
            100                 105                 110         


Lys Asn Met Val Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Asp Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Glu Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Thr Leu Ala Arg Glu Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Gln Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Asp Gln Asp Ile Asn 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Ser Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Thr Lys His Gly Asn 
    370                 375                 380                 


Trp Ser Arg Thr Val Ala Asp Leu Asn 
385                 390             


<210>  43
<211>  376
<212>  PRT
<213>  Saccharomyces eubayanus

<400>  43

Met Thr Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr 
1               5                   10                  15      


Glu His Pro Ser Glu Pro Lys Pro Asn Asp Gln Leu Val Phe Gly Arg 
            20                  25                  30          


Ser Phe Thr Asp His Met Leu Thr Val Glu Trp Thr Ala Ala Asn Gly 
        35                  40                  45              


Trp Asp Val Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro 
    50                  55                  60                  


Ser Ala Tyr Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys 
65                  70                  75                  80  


Ala Tyr Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met 
                85                  90                  95      


Asn Met Lys Arg Met Asn Lys Ser Ala Gln Arg Ile Cys Leu Pro Ala 
            100                 105                 110         


Phe Asp Ser Glu Glu Leu Ile Ala Leu Ile Ala Lys Leu Ile Gln Gln 
        115                 120                 125             


Asp Lys Arg Leu Ile Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg 
    130                 135                 140                 


Pro Thr Met Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp 
145                 150                 155                 160 


Arg Ala Leu Leu Tyr Val Ile Cys Ser Pro Val Gly Pro Tyr Tyr Lys 
                165                 170                 175     


Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg 
            180                 185                 190         


Ala Trp Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala 
        195                 200                 205             


Pro Cys Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln 
    210                 215                 220                 


Asn Leu Trp Leu Phe Gly Pro Glu Asn Asn Ile Thr Glu Val Gly Thr 
225                 230                 235                 240 


Met Asn Ala Phe Phe Val Phe Lys Asp Thr Glu Thr Gly Lys Lys Glu 
                245                 250                 255     


Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg 
            260                 265                 270         


Asp Ser Ile Leu Thr Leu Ala Lys Glu Arg Leu Asp Leu Asp Glu Trp 
        275                 280                 285             


Thr Ile Ser Glu Arg Tyr Cys Thr Ile Gly Glu Val Ser Glu Arg Ser 
    290                 295                 300                 


Lys Lys Gly Glu Leu Val Glu Ala Phe Gly Ser Gly Thr Ala Ala Ile 
305                 310                 315                 320 


Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Pro Ile Asn Ile 
                325                 330                 335     


Pro Leu Leu Pro Gly Glu Gln Thr Gly Pro Leu Thr Lys Glu Val Ala 
            340                 345                 350         


Gln Trp Ile Asn Gln Ile Gln Tyr Gly Glu Val Glu His Gly Asn Trp 
        355                 360                 365             


Ser Arg Val Ile Thr Asp Leu Asn 
    370                 375     


<210>  44
<211>  71
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(71)
<223>  CPA43

<400>  44
caacaaatgg cataccgtaa cacacctgct atgagatcag tcgccctcgc ggctagctcg       60

agcccacaca c                                                            71


<210>  45
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(72)
<223>  CPA44

<400>  45
ggatcaaagt atatgaactc atctagaccc ttgcctgctg gaaccattgg gatccccggg       60

aattcagctt gc                                                           72


<210>  46
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  CPA49

<400>  46
cggtaccggc ttggaatagc catg                                              24


<210>  47
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  CPA50

<400>  47
gaacaccgat cttagattgt actga                                             25


<210>  48
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  CPA51

<400>  48
gcaggtgtgt tacggtatgc catttgttgg                                        30


<210>  49
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  CPA52

<400>  49
gggtctagat gagttcatat actttgatcc agag                                   34


<210>  50
<211>  2213
<212>  DNA
<213>  Artificial

<220>
<223>  Knockout cassette


<220>
<221>  misc_feature
<222>  (1)..(2213)
<223>  ILV2 (se) knockout cassette

<400>  50
cggtaccggc ttggaatagc catgaatctc ggcgcggaaa tatcagcgcc ctccgccgaa       60

atgttgggaa atcgtctttt tctttctttt tttctgaatc tttcatctat tcgatagcga      120

tgattcattt cttctgaaaa aaaaaaaata gaaattttta ttaacatgta attctcttat      180

ccgtttaata tatatgctat cgtttattct cttatcgaat tttcatttct attcccttcc      240

gccatcccta attcaaagta cagatccacg ttactattgt aaattgcttg tttttttgcc      300

ttcactgttt ttaaattatc agccacagtt actttagtca tctgaagtga agattgcata      360

cttttactga ttacaataaa ttgcattaac atagtctata cgcataggag aaaacacaca      420

atagaaatcc actcgccaaa tgatcagaca gtccacactc aagaacttcg ctattaagcg      480

ttgcttccaa caaatggcat accgtaacac acctgctatg agatcagtcg ccctcgcggc      540

tagctcgagc ccacacacca tagcttcaaa atgtttctac tcctttttta ctcttccaga      600

ttttctcgga ctccgcgcat cgccgtacca cttcaaaaca cccaagcaca gcatactaaa      660

ttttccctct ttcttcctct agggtgtcgt taattacccg tactaaaggt ttggaaaaga      720

aaaaagagac cgcctcgttt ctttttcttc gtcgaaaaag gcaataaaaa tttttatcac      780

gtttcttttt cttgaaattt ttttttttag tttttttctc tttcagtgac ctccattgat      840

atttaagtta ataaacggtc ttcaatttct caagtttcag tttcattttt cttgttctat      900

tacaactttt tttacttctt gttcattaga aagaaagcat agcaatctaa tctaaggggc      960

ggtgttgaca attaatcatc ggcatagtat atcggcatag tataatacga caaggtgagg     1020

aactaaacca tggctaaatt gacatctgct gttccagttt tgactgctag agatgttgct     1080

ggtgctgttg aattttggac tgatagattg ggtttctcca gagatttcgt tgaagatgat     1140

ttcgctggtg ttgttagaga tgatgttacc ttgtttatct ccgccgttca agatcaagtt     1200

gttccagata atactttggc ttgggtttgg gttagaggtt tggatgaatt atatgccgaa     1260

tggtccgaag ttgtttctac caattttaga gatgcttctg gtccagctat gaccgaaatt     1320

ggtgaacaac catggggtag agaatttgct ttgagagatc cagctggtaa ctgtgttcat     1380

tttgttgctg aagaacagga ctaacacgtc cgacggcggc ccacgggtcc caggcctcgg     1440

agatccgtcc cccttttcct ttgtcgatat catgtaatta gttatgtcac gcttacattc     1500

acgccctccc cccacatccg ctctaaccga aaaggaagga gttagacaac ctgaagtcta     1560

ggtccctatt tattttttta tagttatgtt agtattaaga acgttattta tatttcaaat     1620

ttttcttttt tttctgtaca gacgcgtgta cgcatgtaac attatactga aaaccttgct     1680

tgagaaggtt ttgggacgct cgaaggcttt aatttgcaag ctgaattccc ggggatccca     1740

atggttccag caggcaaggg tctagatgag ttcatatact ttgatccaga ggttgaaaga     1800

caacaaaatg aattacgtca caagcgtacc aatggtaagc attgaagtct gaaacacatt     1860

ctccattaaa aatttagact taattattat ttaaccatgc ttatatagta catcctgtcc     1920

tacgacaaac acgtatactt ttttaataaa tttctttttt taaactattc acaactagcc     1980

tttaaccatg atgagtagca agtcacacgt ccgagtaggc attagcacat cattagtgaa     2040

tacttcacgc aatgacatga agcttctttt cctcgtctga cacgatttct tctttagtaa     2100

attgtcaaaa atatttccga aaaggggccg ctaaaaaatg cattctctgt taatattgat     2160

ctactgctgt aaataaatga taaaactttc agtacaatct aagatcggtg ttc            2213


<210>  51
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  CPA70

<400>  51
gttctgacct gctgcaacct ccaatactc                                         29


<210>  52
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  CPA71

<400>  52
gcctgtccat aatatcattg atatctatag agtg                                   34


<210>  53
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  CPA91

<400>  53
gcccgggctc gaatcgacag cagtata                                           27


<210>  54
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  CPA96

<400>  54
gatattatgg acaggcgcta gctcgagccc acac                                   34


<210>  55
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(31)
<223>  CPA111

<400>  55
ggcaagggac accatacatc acctaatgct g                                      31


<210>  56
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  CPA112

<400>  56
gttgcagcag gtcagaactt cttggaaata ggagc                                  35


<210>  57
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  CPA113

<400>  57
cgattcgagc ccgggcgctt tggcatccac                                        30


<210>  58
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  CPA114

<400>  58
gatatgcggt attcgtttac attcctgata tattc                                  35


<210>  59
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  CPA128

<400>  59
tattatggac aggcgctagc tcgagcccac acacc                                  35


<210>  60
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  CPA129

<400>  60
tcgagctagc gcctgtccat aatatcattg atatc                                  35


<210>  61
<211>  5307
<212>  DNA
<213>  Artificial

<220>
<223>  Integration cassette


<220>
<221>  misc_feature
<222>  (1)..(5307)
<223>  ILV3 (se) NTC integration cassette

<400>  61
ggcaagggac accatacatc acctaatgct gttaattata accaacttga caacgattgc       60

acaagaaaag agtatacctg tgaagacagc caaaacgctt aacatgttat gacataaatt      120

gcagacaaga aattggatgt attttacaga ctttgcattc ctgtctgaaa gcctttttac      180

ataaaaatgg tttcattagt agcacttcgt atcgttttca aataatgatg agatgctcca      240

aaaggaaagt tggcacagaa aaaatgacgc gcctttcctg tttaccgtta aacttctcag      300

aaaaagtata ctcgacccat ttttaagatt ggtgatggat agaatttcat ttaacataat      360

gctgcaaata tagattgatt tcaatctacg gagtccaacg cattgaacag cttcaattga      420

atagatatgc tcctatttcc aagaagttct gacctgctgc aacctccaat actcatacac      480

atctctatat attcaatctt taatctttac tgtcatcttc cacatatcat tcctcacgag      540

cgggcaccta ctatttttcc ccctctgttt aaggtgaaaa gggccccaat gctaccagct      600

tttacctcca cacgactctc cacacagcag caaccacaca gcaatgccat ccgacgcagc      660

agccagcacc ggcctgccca cgccgtggac tgtcaggtac agcaagtcca agaaaagaga      720

gtacttcttc aacccggaca cgaagcactc gcagtgggag gagcccgagg gtacggataa      780

ggaacagctg cacgagtatc tgaaagacca cccaatgcgt gtaaggtgtc tgcacatcct      840

catcaagcac caggactcga gaagacctgc ttcgcaccgg tccgagaaca tcaccatatc      900

caagcaagag gccacggacg agctaaagac cctggtcacg aggctggacg acgcttccaa      960

gaccaactcc ttcgaggcgc tggctaagga gaggtccgac tgctcttcgt acaagagggg     1020

cggcgacctg ggctggttcg gcaggggcga gatgcagccc agtttcgagg acgccgcctt     1080

caagctcaag gtcggagaag tgagcgacat tgtcgagtcg ggcagcggtg tccatttaat     1140

caagcgtgtg ggttagtcgt ccgccctaat ccctactctc caaatcacgt tgttgcttca     1200

cctcacactc gaacgcacga aaaaattcta aaatactaga ggcattacta acgctgcctt     1260

tttgttacga gcggaaccgg acatgaaaaa aaaaattttc ttttaacttt tttcaccaga     1320

tgactcaata aattattagt acattatata atataacaaa agaagagact ggtcttttta     1380

gcgtgtacac acatactctc tagttataac gtttcttgtt ttctcatttg caaatacaac     1440

caagaagtat cagcagagat gggcttgtta acgaaagtag ccacgtcgag acaattctct     1500

acaacgagat ccgttgccaa gaaactaaac aagtattcct acatcatcac tgaaccaaag     1560

ggccaaggtg cctcccaggc catgctttac gctaccgggt tcaagaagga tgacttccaa     1620

aagcctcagg ttggtgtcgg ttcatgctgg tggtctggta acccatgcaa catgcatctg     1680

ttggacttga acaacagatg ttcccaatcc atcgaaaagg ctggcctaaa ggccatgcag     1740

ttcaacacca tcggtgtttc tgacggtatc tccatgggta ccaagggtat gagatactct     1800

ttgcaaagta gagagatcat tgcggactcg tttgaaacca tcatgatggc tcagcattac     1860

gatgccaaca tcgccatccc atcttgtgac aagaacatgc ccggtgtcat gatggccatg     1920

ggtagacaca atagaccctc catcatggtc tacggtggta ccatcttgcc cggtcaccca     1980

acctgcgggt cctccaagat ctccaaaaac atcgacattg tctcagcttt ccaatcttac     2040

ggtgagtata tctccaagca gttcactgaa gaagagagag aagatgtcgt ggaacacgcc     2100

tgccctggtc ctggttcttg tggtggtatg tacaccgcca acacaatggc ctctgccgca     2160

gaagtcctag gtttaaccat tccaaactcc tcttccttcc ccgccgtgtc caagcagaag     2220

ttggccgagt gtgacaatat tggtgaatac atcaagacaa caatggaatt gggcattttg     2280

ccccgtgaca tcctcaccaa ggaggccttt gaaaatgcca ttacttacgt cgttgccaca     2340

ggtgggtcca ccaatgctgt tttgcatctg gttgccgttg ctcattccgc gggtgttaag     2400

ttgtctccag atgatttcca aagaatcagt aacaccacac cattgatcgg tgacttcaag     2460

ccttccggta aatacgtcat ggctgacttg atcaacgtcg gtggtacaca atccgtgatt     2520

aagtacctat acgaaaacaa catgttacat ggtaacacca tgactgtcac cggtgacact     2580

ttggcagaac gtgccaagaa ggcaccaagc ttgcctgaag gccaagagat catcaaacct     2640

ctttcccatc caatcaagac cagcggtcac ttacaaatct tatacggttc attggcgcca     2700

ggtggtgccg tgggtaaaat taccggtaag gaaggtactt acttcaaagg taaggcccgt     2760

gtctacgaag aagaaggtgc ctttattgaa gctttggaaa agggcgaaat caagaagggt     2820

gaaaaaactg ttgttattat cagatacgaa ggtccaagag gtgctccagg tatgcctgaa     2880

atgctaaagc cttcttctgc tctaatgggg tacggtttag gtaaagatgt cgcattgttg     2940

actgatggta gattctccgg tggttctcat gggttcttga tcggtcacat tgtcccagaa     3000

gccgctgaag gtggacctat tggtcttgtg aaagacggtg acgaaatcat tatcgatgct     3060

gacaacaaca agattgattt gttgatctcc gaacaggaaa tgtctcaacg taagcaaaac     3120

tgggtcgctc ctccacctcg ttacacaaga ggtactttat ccaaatatgc taagttggtt     3180

tccaacgctt ccagcggttg tgtcctagat gcttgatgca ttataggcac caatcgatga     3240

atatatatac agattctcct ttcctcattt tttctcaccc ccaatctttt tctttatata     3300

tataaatatt tattatagtc cattgaatgg ataaaacatt tatttaaaaa aatcctattt     3360

tttttacaag tctcagttgg taatgtatcc accattactg gccctgttgt gatgcagcta     3420

aggccttttg tctcaatttt ctgcccgcgt atttactgac aaatggtaac aatgcggtat     3480

ttaatgcaat gagggcaact aaaataccat aattcctccc catcttgcct cttgacaagt     3540

caaaaaaaat cactctatag atatcaatga tattatggac aggcgctagc tcgagcccac     3600

acaccatagc ttcaaaatgt ttctactcct tttttactct tccagatttt ctcggactcc     3660

gcgcatcgcc gtaccacttc aaaacaccca agcacagcat actaaatttt ccctctttct     3720

tcctctaggg tgtcgttaat tacccgtact aaaggtttgg aaaagaaaaa agagaccgcc     3780

tcgtttcttt ttcttcgtcg aaaaaggcaa taaaaatttt tatcacgttt ctttttcttg     3840

aaattttttt ttttagtttt tttctctttc agtgacctcc attgatattt aagttaataa     3900

acggtcttca atttctcaag tttcagtttc atttttcttg ttctattaca acttttttta     3960

cttcttgttc attagaaaga aagcatagca atctaatcta aggggcggtg ttgacaatta     4020

atcatcggca tagtatatcg gcatagtata atacgacaag gtgaggaact aaaccatggg     4080

tactactttg gatgataccg cttatagata cagaacttct gttccaggtg atgctgaagc     4140

tattgaagct ttggatggtt ctttcactac tgacactgtt ttcagagtta ctgctactgg     4200

tgatggtttc actttgagag aagttccagt tgatccacca ttgactaagg tttttccaga     4260

tgatgaatcc gatgacgaat ctgatgatgg tgaagatggt gatccagatt ctagaacttt     4320

tgttgcttat ggtgatgacg gtgatttggc tggttttgtt gttgtttctt actctggttg     4380

gaatagaaga ttgaccgtcg aagatattga agttgctcca gaacatagag gtcatggtgt     4440

tggtagagct ttgatgggtt tagctactga atttgctaga gaacgtggtg ctggtcattt     4500

gtggttggaa gttactaatg ttaacgctcc agctattcat gcctatagaa gaatgggttt     4560

taccttgtgt ggtttggata ctgcattata cgatggtact gcttcagatg gtgaacaagc     4620

cttgtatatg tctatgccat gtccatgatc agtactgaca ataaaaagat tcttgttttc     4680

aagaacttgt catttgtata gtttttttat attgtagttg ttctatttta atcaaatgtt     4740

agcgtgattt atattttttt tcgcctcgac atcatctgcc cagatgcgaa gttaagtgcg     4800

cagaaagtaa tatcatgcgt caatcgtatg tgaatgctgg tcgctatact gctgtcgatt     4860

cgagcccggg cgctttggca tccacgctga cacttttcct cgttgggaag gaataaaaag     4920

caagtaacac tttttctgag cattttatta cgttattcaa ctactaatag agttgatttg     4980

ttacttgcta aaatcttttt atatttcttt tagccccgac agaacttgtt gcaaatgaat     5040

acaaaccgtg aacttcccga tatcattcta attgaaccca gatatttaca catgtacttc     5100

ttactcattt tcaatgtcag cttaaatatc gtctaaaaca atattttact agatacgcag     5160

ttcaatcttc gcgcatattt tcgcgaaagt ccaaattgcg tacgtggttt tatgtcaaag     5220

tgaccgccgt tgtagcgtac tttttcctat aagacaagct cgtgatatca ggaatatatc     5280

aggaatgtaa acgaataccg catatct                                         5307


<210>  62
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  CPA74

<400>  62
gtagtaagtg ataagcgaat ttggc                                             25


<210>  63
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(31)
<223>  CPA75

<400>  63
gcgtcacagc aaccagtagc tcagccaaaa c                                      31


<210>  64
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  CPA86

<400>  64
cttttgctca catgtgtttg tagtaagtga taagcgaatt tgg                         43


<210>  65
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  CPA87

<400>  65
ctcacttggc cagtttgcgt cacagcaacc agtag                                  35


<210>  66
<211>  2595
<212>  DNA
<213>  Artificial

<220>
<223>  Expression cassette


<220>
<221>  misc_feature
<222>  (1)..(2595)
<223>  ILV5 (sc) expression cassette

<400>  66
cttttgctca catgtgtttg tagtaagtga taagcgaatt tggctaagaa cgttgtaagt       60

gaacaaggga cctcttttgc ctttcaaaaa aggattaaat ggagttaatc attgagattt      120

agttttcgtt agattctgta tccctaaata actcccttac ccgacgggaa ggcacaaaag      180

acttgaataa tagcaaacgg ccagtagcca agaccaaata atactagagt taactgatgg      240

tcttaaacag gcattacgtg gtgaactcca agaccaatat acaaaatatc gataagttat      300

tcttgcccac caatttaagg agcctacatc aggacagtag taccattcct cagagaagag      360

gtatacataa caagaaaatc gcgtgaacac cttatataac ttagcccgtt attgagctaa      420

aaaaccttgc aaaatttcct atgaataaga atacttcaga cgtgataaaa atttactttc      480

taactcttct cacgctgccc ctatctgttc ttccgctcta ccgtgagaaa taaagcatcg      540

agtacggcag ttcgctgtca ctgaactaaa acaataaggc tagttcgaat gatgaacttg      600

cttgctgtca aacttctgag ttgccgctga tgtgacactg tgacaataaa ttcaaaccgg      660

ttatagcggt ctcctccggt accggttctg ccacctccaa tagagctcag taggagtcag      720

aacctctgcg gtggctgtca gtgactcatc cgcgtttcgt aagttgtgcg cgtgcacatt      780

tcgcccgttc ccgctcatct tgcagcaggc gaaattttca tcacgcggta ggacgcaaaa      840

aaaaaataat taatcgtaca agaatcttgg aaaaaaaatt gaaaaatttt gtataaaagg      900

gatgacctaa cttgactcaa tggcttttac acccagtatt ttccctttcc ttgtttgtta      960

caattataga agcaagacaa aaacatatag acaacctatt cctaggagtt atattttttt     1020

accctaccag caatataagt aaaaaataaa acatgttgag aactcaagcc gccagattga     1080

tctgcaactc ccgtgtcatc actgctaaga gaacctttgc tttggccacc cgtgctgctg     1140

cttacagcag accagctgcc cgtttcgtta agccaatgat cactacccgt ggtttgaagc     1200

aaatcaactt cggtggtact gttgaaaccg tctacgaaag agctgactgg ccaagagaaa     1260

agttgttgga ctacttcaag aacgacactt ttgctttgat cggttacggt tcccaaggtt     1320

acggtcaagg tttgaacttg agagacaacg gtttgaacgt tatcattggt gtccgtaaag     1380

atggtgcttc ttggaaggct gccatcgaag acggttgggt tccaggcaag aacttgttca     1440

ctgttgaaga tgctatcaag agaggttgtt acgttatgaa cttgttgtcc gatgccgctc     1500

aatcagaaac ctggcctgct atcaagccat tgttgaccaa gggtaagact ttgtacttct     1560

cccacggttt ctccccagtc ttcaaggact tgactcacgt tgaaccacca aaggacttag     1620

atgttatctt ggttgctcca aagggttccg gtagaactgt cagatctttg ttcaaggaag     1680

gtcgtggtat taactcttct tacgccgtct ggaacgatgt caccggtaag gctcacgaaa     1740

aggcccaagc tttggccgtt gccattggtt ccggttacgt ttaccaaacc actttcgaaa     1800

gagaagtcaa ctctgacttg tacggtgaaa gaggttgttt aatgggtggt atccacggta     1860

tgttcttggc tcaatacgac gtcttgagag aaaacggtca ctccccatct gaagctttca     1920

acgaaaccgt cgaagaagct acccaatctc tatacccatt gatcggtaag tacggtatgg     1980

attacatgta cgatgcttgt tccaccaccg ccagaagagg tgctttggac tggtacccaa     2040

tcttcaagaa tgctttgaag cctgttttcc aagacttgta cgaatctacc aagaacggta     2100

ccgaaaccaa gagatctttg gaattcaact ctcaacctga ctacagagaa aagctagaaa     2160

aggaattaga caccatcaga aacatggaaa tctggaaggt tggtaaggaa gtcagaaagt     2220

tgagaccaga aaaccaataa agaggaaaat aatatcaagt gctggaaact ttttctcttg     2280

gaatttttgc aacatcaagt catagtcaat tgaattgacc caatttcaca tttaagattt     2340

tttatttttt catccgacat acatctgtac actaggaagc cctgtttttc tgaagcagct     2400

tcaaatatat atatttttta catatttatt atgattcaat gaacaatcta attaaatcga     2460

aaacaagaac cgaaacgcga ataaataatt tatttagatg gtgacaagtg tataagtcct     2520

catcgggaca gctacgattt ctctttcggt tttggctgag ctactggttg ctgtgacgca     2580

aactggccaa gtgag                                                      2595


<210>  67
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  ScILV3_F

<400>  67
tatgttctta ttccctcttg                                                   20


<210>  68
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  ScILV3_R

<400>  68
atgtttatcc attcaatgga c                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  ScBAT1_F

<400>  69
atgttgcaga gacattcctt g                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  ScBAT1_R

<400>  70
aggtcaacaa tttcaaagag c                                                 21


<210>  71
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  ScBAT2_F

<400>  71
gaccgcacta caccaaagtt taatg                                             25


<210>  72
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  ScBAT2_R

<400>  72
gataggccag cactagatga caag                                              24


<210>  73
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  ScILV6_F

<400>  73
ctaacaagaa cggggaatgg                                                   20


<210>  74
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  ScILV6_R

<400>  74
cacttagaga agccaccaag g                                                 21


