                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals s.a.
 
<120>  HSV gE ANTIBODIES

<130>  VB66942P EP

<160>  451   

<170>  PatentIn version 3.5

<210>  1
<211>  548
<212>  PRT
<213>  herpes simplex virus 2

<400>  1

Met Ala Arg Gly Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser 
            20                  25                  30          


Gly Glu Asp Val Val Leu Leu Pro Ala Pro Ala Gly Pro Glu Glu Arg 
        35                  40                  45              


Thr Arg Ala His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys 
    50                  55                  60                  


Gly Pro Leu Arg Pro Ser Trp Val Ala Leu Trp Pro Pro Arg Arg Val 
65                  70                  75                  80  


Leu Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu 
                85                  90                  95      


Ala Ile Ala Tyr Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Leu Tyr 
            100                 105                 110         


Ser Glu Leu Ala Trp Arg Asp Arg Val Ala Val Val Asn Glu Ser Leu 
        115                 120                 125             


Val Ile Tyr Gly Ala Leu Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser 
    130                 135                 140                 


Val Val Gly Leu Ser Asp Glu Ala Arg Gln Val Ala Ser Val Val Leu 
145                 150                 155                 160 


Val Val Glu Pro Ala Pro Val Pro Thr Pro Thr Pro Asp Asp Tyr Asp 
                165                 170                 175     


Glu Glu Asp Asp Ala Gly Val Ser Glu Arg Thr Pro Val Ser Val Pro 
            180                 185                 190         


Pro Pro Thr Pro Pro Arg Arg Pro Pro Val Ala Pro Pro Thr His Pro 
        195                 200                 205             


Arg Val Ile Pro Glu Val Ser His Val Arg Gly Val Thr Val His Met 
    210                 215                 220                 


Glu Thr Pro Glu Ala Ile Leu Phe Ala Pro Gly Glu Thr Phe Gly Thr 
225                 230                 235                 240 


Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gly Pro Tyr Ala Met 
                245                 250                 255     


Asp Val Val Trp Met Arg Phe Asp Val Pro Ser Ser Cys Ala Glu Met 
            260                 265                 270         


Arg Ile Tyr Glu Ala Cys Leu Tyr His Pro Gln Leu Pro Glu Cys Leu 
        275                 280                 285             


Ser Pro Ala Asp Ala Pro Cys Ala Val Ser Ser Trp Ala Tyr Arg Leu 
    290                 295                 300                 


Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Thr Pro Pro Pro Arg 
305                 310                 315                 320 


Cys Phe Ala Glu Ala Arg Met Glu Pro Val Pro Gly Leu Ala Trp Leu 
                325                 330                 335     


Ala Ser Thr Val Asn Leu Glu Phe Gln His Ala Ser Pro Gln His Ala 
            340                 345                 350         


Gly Leu Tyr Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala Trp 
        355                 360                 365             


Gly His Met Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala Val Val 
    370                 375                 380                 


Glu Gln His Leu Pro Gln Arg Gln Pro Glu Pro Val Glu Pro Thr Arg 
385                 390                 395                 400 


Pro His Val Arg Ala Pro Pro Pro Ala Pro Ser Ala Arg Gly Pro Leu 
                405                 410                 415     


Arg Leu Gly Ala Val Leu Gly Ala Ala Leu Leu Leu Ala Ala Leu Gly 
            420                 425                 430         


Leu Ser Ala Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ser Trp Arg 
        435                 440                 445             


Ala Val Lys Ser Arg Ala Ser Ala Thr Gly Pro Thr Tyr Ile Arg Val 
    450                 455                 460                 


Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu Gly Glu 
465                 470                 475                 480 


Arg Asp Gly Ser Leu Trp Gln Asp Pro Pro Glu Arg Pro Asp Ser Pro 
                485                 490                 495     


Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala Pro Ser 
            500                 505                 510         


Val Tyr Pro His Ser Glu Gly Arg Lys Ser Arg Arg Pro Leu Thr Thr 
        515                 520                 525             


Phe Gly Ser Gly Ser Pro Gly Arg Arg His Ser Gln Ala Ser Tyr Ser 
    530                 535                 540                 


Ser Val Leu Trp 
545             


<210>  2
<211>  372
<212>  PRT
<213>  herpes simplex virus 2

<400>  2

Met Pro Gly Arg Ser Leu Gln Gly Leu Ala Ile Leu Gly Leu Trp Val 
1               5                   10                  15      


Cys Ala Thr Gly Leu Val Val Arg Gly Pro Thr Val Ser Leu Val Ser 
            20                  25                  30          


Asp Ser Leu Val Asp Ala Gly Ala Val Gly Pro Gln Gly Phe Val Glu 
        35                  40                  45              


Glu Asp Leu Arg Val Phe Gly Glu Leu His Phe Val Gly Ala Gln Val 
    50                  55                  60                  


Pro His Thr Asn Tyr Tyr Asp Gly Ile Ile Glu Leu Phe His Tyr Pro 
65                  70                  75                  80  


Leu Gly Asn His Cys Pro Arg Val Val His Val Val Thr Leu Thr Ala 
                85                  90                  95      


Cys Pro Arg Arg Pro Ala Val Ala Phe Thr Leu Cys Arg Ser Thr His 
            100                 105                 110         


His Ala His Ser Pro Ala Tyr Pro Thr Leu Glu Leu Gly Leu Ala Arg 
        115                 120                 125             


Gln Pro Leu Leu Arg Val Arg Thr Ala Thr Arg Asp Tyr Ala Gly Leu 
    130                 135                 140                 


Tyr Val Leu Arg Val Trp Val Gly Ser Ala Thr Asn Ala Ser Leu Phe 
145                 150                 155                 160 


Val Leu Gly Val Ala Leu Ser Ala Asn Gly Thr Phe Val Tyr Asn Gly 
                165                 170                 175     


Ser Asp Tyr Gly Ser Cys Asp Pro Ala Gln Leu Pro Phe Ser Ala Pro 
            180                 185                 190         


Arg Leu Gly Pro Ser Ser Val Tyr Thr Pro Gly Ala Ser Arg Pro Thr 
        195                 200                 205             


Pro Pro Arg Thr Thr Thr Ser Pro Ser Ser Pro Arg Asp Pro Thr Pro 
    210                 215                 220                 


Ala Pro Gly Asp Thr Gly Thr Pro Ala Pro Ala Ser Gly Glu Arg Ala 
225                 230                 235                 240 


Pro Pro Asn Ser Thr Arg Ser Ala Ser Glu Ser Arg His Arg Leu Thr 
                245                 250                 255     


Val Ala Gln Val Ile Gln Ile Ala Ile Pro Ala Ser Ile Ile Ala Phe 
            260                 265                 270         


Val Phe Leu Gly Ser Cys Ile Cys Phe Ile His Arg Cys Gln Arg Arg 
        275                 280                 285             


Tyr Arg Arg Pro Arg Gly Gln Ile Tyr Asn Pro Gly Gly Val Ser Cys 
    290                 295                 300                 


Ala Val Asn Glu Ala Ala Met Ala Arg Leu Gly Ala Glu Leu Arg Ser 
305                 310                 315                 320 


His Pro Asn Thr Pro Pro Lys Pro Arg Arg Arg Ser Ser Ser Ser Thr 
                325                 330                 335     


Thr Met Pro Ser Leu Thr Ser Ile Ala Glu Glu Ser Glu Pro Gly Pro 
            340                 345                 350         


Val Val Leu Leu Ser Val Ser Pro Arg Pro Arg Ser Gly Pro Thr Ala 
        355                 360                 365             


Pro Gln Glu Val 
    370         


<210>  3
<211>  550
<212>  PRT
<213>  herpes simplex virus 1

<400>  3

Met Asp Arg Gly Ala Val Val Gly Phe Leu Leu Gly Val Cys Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Gly Thr Pro Lys Thr Ser Trp Arg Arg Val Ser Val 
            20                  25                  30          


Gly Glu Asp Val Ser Leu Leu Pro Ala Pro Gly Pro Thr Gly Arg Gly 
        35                  40                  45              


Pro Thr Gln Lys Leu Leu Trp Ala Val Glu Pro Leu Asp Gly Cys Gly 
    50                  55                  60                  


Pro Leu His Pro Ser Trp Val Ser Leu Met Pro Pro Lys Gln Val Pro 
65                  70                  75                  80  


Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Val Pro Leu Ala 
                85                  90                  95      


Met Ala Tyr Ala Pro Pro Ala Pro Ser Ala Thr Gly Gly Leu Arg Thr 
            100                 105                 110         


Asp Phe Val Trp Gln Glu Arg Ala Ala Val Val Asn Arg Ser Leu Val 
        115                 120                 125             


Ile His Gly Val Arg Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val 
    130                 135                 140                 


Gly Asp Ile Lys Asp Pro Ala Arg Gln Val Ala Ser Val Val Leu Val 
145                 150                 155                 160 


Val Gln Pro Ala Pro Val Pro Thr Pro Pro Pro Thr Pro Ala Asp Tyr 
                165                 170                 175     


Asp Glu Asp Asp Asn Asp Glu Gly Glu Asp Glu Ser Leu Ala Gly Thr 
            180                 185                 190         


Pro Ala Ser Gly Thr Pro Arg Leu Pro Pro Pro Pro Ala Pro Pro Arg 
        195                 200                 205             


Ser Trp Pro Ser Ala Pro Glu Val Ser His Val Arg Gly Val Thr Val 
    210                 215                 220                 


Arg Met Glu Thr Pro Glu Ala Ile Leu Phe Ser Pro Gly Glu Thr Phe 
225                 230                 235                 240 


Ser Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gln Thr Tyr 
                245                 250                 255     


Ser Met Asp Val Val Trp Leu Arg Phe Asp Val Pro Thr Ser Cys Ala 
            260                 265                 270         


Glu Met Arg Ile Tyr Glu Ser Cys Leu Tyr His Pro Gln Leu Pro Glu 
        275                 280                 285             


Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Ala Ser Thr Trp Thr Ser 
    290                 295                 300                 


Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Asn Pro Pro 
305                 310                 315                 320 


Pro Arg Cys Ser Ala Glu Ala His Met Glu Pro Val Pro Gly Leu Ala 
                325                 330                 335     


Trp Gln Ala Ala Ser Val Asn Leu Glu Phe Arg Asp Ala Ser Pro Gln 
            340                 345                 350         


His Ser Gly Leu Tyr Leu Cys Val Val Tyr Val Asn Asp His Ile His 
        355                 360                 365             


Ala Trp Gly His Ile Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala 
    370                 375                 380                 


Val Val Glu Gln Pro Leu Pro Gln Arg Gly Ala Asp Leu Ala Glu Pro 
385                 390                 395                 400 


Thr His Pro His Val Gly Ala Pro Pro His Ala Pro Pro Thr His Gly 
                405                 410                 415     


Ala Leu Arg Leu Gly Ala Val Met Gly Ala Ala Leu Leu Leu Ser Ala 
            420                 425                 430         


Leu Gly Leu Ser Val Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ala 
        435                 440                 445             


Trp Arg Ala Val Lys Ser Arg Ala Ser Gly Lys Gly Pro Thr Tyr Ile 
    450                 455                 460                 


Arg Val Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu 
465                 470                 475                 480 


Gly Glu Arg Asp Gln Val Pro Trp Leu Ala Pro Pro Glu Arg Pro Asp 
                485                 490                 495     


Ser Pro Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala 
            500                 505                 510         


Pro Ser Val Tyr Pro Arg Ser Asp Gly His Gln Ser Arg Arg Gln Leu 
        515                 520                 525             


Thr Thr Phe Gly Ser Gly Arg Pro Asp Arg Arg Tyr Ser Gln Ala Ser 
    530                 535                 540                 


Asp Ser Ser Val Phe Trp 
545                 550 


<210>  4
<211>  390
<212>  PRT
<213>  herpes simplex virus 1

<400>  4

Met Pro Cys Arg Pro Leu Gln Gly Leu Val Leu Val Gly Leu Trp Val 
1               5                   10                  15      


Cys Ala Thr Ser Leu Val Val Arg Gly Pro Thr Val Ser Leu Val Ser 
            20                  25                  30          


Asn Ser Phe Val Asp Ala Gly Ala Leu Gly Pro Asp Gly Val Val Glu 
        35                  40                  45              


Glu Asp Leu Leu Ile Leu Gly Glu Leu Arg Phe Val Gly Asp Gln Val 
    50                  55                  60                  


Pro His Thr Thr Tyr Tyr Asp Gly Gly Val Glu Leu Trp His Tyr Pro 
65                  70                  75                  80  


Met Gly His Lys Cys Pro Arg Val Val His Val Val Thr Val Thr Ala 
                85                  90                  95      


Cys Pro Arg Arg Pro Ala Val Ala Phe Ala Leu Cys Arg Ala Thr Asp 
            100                 105                 110         


Ser Thr His Ser Pro Ala Tyr Pro Thr Leu Glu Leu Asn Leu Ala Gln 
        115                 120                 125             


Gln Pro Leu Leu Arg Val Gln Arg Ala Thr Arg Asp Tyr Ala Gly Val 
    130                 135                 140                 


Tyr Val Leu Arg Val Trp Val Gly Asp Ala Pro Asn Ala Ser Leu Phe 
145                 150                 155                 160 


Val Leu Gly Met Ala Ile Ala Ala Glu Gly Thr Leu Ala Tyr Asn Gly 
                165                 170                 175     


Ser Ala Tyr Gly Ser Cys Asp Pro Lys Leu Leu Pro Ser Ser Ala Pro 
            180                 185                 190         


Arg Leu Ala Pro Ala Ser Val Tyr Gln Pro Ala Pro Asn Gln Ala Ser 
        195                 200                 205             


Thr Pro Ser Thr Thr Thr Ser Thr Pro Ser Thr Thr Ile Pro Ala Pro 
    210                 215                 220                 


Ser Thr Thr Ile Pro Ala Pro Gln Ala Ser Thr Thr Pro Phe Pro Thr 
225                 230                 235                 240 


Gly Asp Pro Lys Pro Gln Pro Pro Gly Val Asn His Glu Pro Pro Ser 
                245                 250                 255     


Asn Ala Thr Arg Ala Thr Arg Asp Ser Arg Tyr Ala Leu Thr Val Thr 
            260                 265                 270         


Gln Ile Ile Gln Ile Ala Ile Pro Ala Ser Ile Ile Ala Leu Val Phe 
        275                 280                 285             


Leu Gly Ser Cys Ile Cys Phe Ile His Arg Cys Gln Arg Arg Tyr Arg 
    290                 295                 300                 


Arg Ser Arg Arg Pro Ile Tyr Ser Pro Gln Met Pro Thr Gly Ile Ser 
305                 310                 315                 320 


Cys Ala Val Asn Glu Ala Ala Met Ala Arg Leu Gly Ala Glu Leu Lys 
                325                 330                 335     


Ser His Pro Ser Thr Pro Pro Lys Ser Arg Arg Arg Ser Ser Arg Thr 
            340                 345                 350         


Pro Met Pro Ser Leu Thr Ala Ile Ala Glu Glu Ser Glu Pro Ala Gly 
        355                 360                 365             


Ala Ala Gly Leu Pro Thr Pro Pro Val Asp Pro Thr Thr Pro Thr Pro 
    370                 375                 380                 


Thr Pro Pro Leu Leu Val 
385                 390 


<210>  5
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV2 gE ectodomain

<400>  5

Met Ala Arg Gly Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser 
            20                  25                  30          


Gly Glu Asp Val Val Leu Leu Pro Ala Pro Ala Gly Pro Glu Glu Arg 
        35                  40                  45              


Thr Arg Ala His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys 
    50                  55                  60                  


Gly Pro Leu Arg Pro Ser Trp Val Ala Leu Trp Pro Pro Arg Arg Val 
65                  70                  75                  80  


Leu Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu 
                85                  90                  95      


Ala Ile Ala Tyr Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Leu Tyr 
            100                 105                 110         


Ser Glu Leu Ala Trp Arg Asp Arg Val Ala Val Val Asn Glu Ser Leu 
        115                 120                 125             


Val Ile Tyr Gly Ala Leu Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser 
    130                 135                 140                 


Val Val Gly Leu Ser Asp Glu Ala Arg Gln Val Ala Ser Val Val Leu 
145                 150                 155                 160 


Val Val Glu Pro Ala Pro Val Pro Thr Pro Thr Pro Asp Asp Tyr Asp 
                165                 170                 175     


Glu Glu Asp Asp Ala Gly Val Ser Glu Arg Thr Pro Val Ser Val Pro 
            180                 185                 190         


Pro Pro Thr Pro Pro Arg Arg Pro Pro Val Ala Pro Pro Thr His Pro 
        195                 200                 205             


Arg Val Ile Pro Glu Val Ser His Val Arg Gly Val Thr Val His Met 
    210                 215                 220                 


Glu Thr Pro Glu Ala Ile Leu Phe Ala Pro Gly Glu Thr Phe Gly Thr 
225                 230                 235                 240 


Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gly Pro Tyr Ala Met 
                245                 250                 255     


Asp Val Val Trp Met Arg Phe Asp Val Pro Ser Ser Cys Ala Glu Met 
            260                 265                 270         


Arg Ile Tyr Glu Ala Cys Leu Tyr His Pro Gln Leu Pro Glu Cys Leu 
        275                 280                 285             


Ser Pro Ala Asp Ala Pro Cys Ala Val Ser Ser Trp Ala Tyr Arg Leu 
    290                 295                 300                 


Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Thr Pro Pro Pro Arg 
305                 310                 315                 320 


Cys Phe Ala Glu Ala Arg Met Glu Pro Val Pro Gly Leu Ala Trp Leu 
                325                 330                 335     


Ala Ser Thr Val Asn Leu Glu Phe Gln His Ala Ser Pro Gln His Ala 
            340                 345                 350         


Gly Leu Tyr Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala Trp 
        355                 360                 365             


Gly His Met Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala Val Val 
    370                 375                 380                 


Glu Gln His Leu Pro Gln Arg Gln Pro Glu Pro Val Glu Pro Thr Arg 
385                 390                 395                 400 


Pro His Val Arg Ala Pro Pro Pro Ala Pro Ser Ala Arg Gly Pro Leu 
                405                 410                 415     


Arg Leu Gly 
            


<210>  6
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV2 gI ectodomain

<400>  6

Met Pro Gly Arg Ser Leu Gln Gly Leu Ala Ile Leu Gly Leu Trp Val 
1               5                   10                  15      


Cys Ala Thr Gly Leu Val Val Arg Gly Pro Thr Val Ser Leu Val Ser 
            20                  25                  30          


Asp Ser Leu Val Asp Ala Gly Ala Val Gly Pro Gln Gly Phe Val Glu 
        35                  40                  45              


Glu Asp Leu Arg Val Phe Gly Glu Leu His Phe Val Gly Ala Gln Val 
    50                  55                  60                  


Pro His Thr Asn Tyr Tyr Asp Gly Ile Ile Glu Leu Phe His Tyr Pro 
65                  70                  75                  80  


Leu Gly Asn His Cys Pro Arg Val Val His Val Val Thr Leu Thr Ala 
                85                  90                  95      


Cys Pro Arg Arg Pro Ala Val Ala Phe Thr Leu Cys Arg Ser Thr His 
            100                 105                 110         


His Ala His Ser Pro Ala Tyr Pro Thr Leu Glu Leu Gly Leu Ala Arg 
        115                 120                 125             


Gln Pro Leu Leu Arg Val Arg Thr Ala Thr Arg Asp Tyr Ala Gly Leu 
    130                 135                 140                 


Tyr Val Leu Arg Val Trp Val Gly Ser Ala Thr Asn Ala Ser Leu Phe 
145                 150                 155                 160 


Val Leu Gly Val Ala Leu Ser Ala Asn Gly Thr Phe Val Tyr Asn Gly 
                165                 170                 175     


Ser Asp Tyr Gly Ser Cys Asp Pro Ala Gln Leu Pro Phe Ser Ala Pro 
            180                 185                 190         


Arg Leu Gly Pro Ser Ser Val Tyr Thr Pro Gly Ala Ser Arg Pro Thr 
        195                 200                 205             


Pro Pro Arg Thr Thr Thr Ser Pro Ser Ser Pro Arg Asp Pro Thr Pro 
    210                 215                 220                 


Ala Pro Gly Asp Thr Gly Thr Pro Ala Pro Ala Ser Gly Glu Arg Ala 
225                 230                 235                 240 


Pro Pro Asn Ser Thr Arg Ser Ala Ser Glu Ser Arg His Arg Leu Thr 
                245                 250                 255     


<210>  7
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV1 gE ectodomain

<400>  7

Met Asp Arg Gly Ala Val Val Gly Phe Leu Leu Gly Val Cys Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Gly Thr Pro Lys Thr Ser Trp Arg Arg Val Ser Val 
            20                  25                  30          


Gly Glu Asp Val Ser Leu Leu Pro Ala Pro Gly Pro Thr Gly Arg Gly 
        35                  40                  45              


Pro Thr Gln Lys Leu Leu Trp Ala Val Glu Pro Leu Asp Gly Cys Gly 
    50                  55                  60                  


Pro Leu His Pro Ser Trp Val Ser Leu Met Pro Pro Lys Gln Val Pro 
65                  70                  75                  80  


Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Val Pro Leu Ala 
                85                  90                  95      


Met Ala Tyr Ala Pro Pro Ala Pro Ser Ala Thr Gly Gly Leu Arg Thr 
            100                 105                 110         


Asp Phe Val Trp Gln Glu Arg Ala Ala Val Val Asn Arg Ser Leu Val 
        115                 120                 125             


Ile His Gly Val Arg Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val 
    130                 135                 140                 


Gly Asp Ile Lys Asp Pro Ala Arg Gln Val Ala Ser Val Val Leu Val 
145                 150                 155                 160 


Val Gln Pro Ala Pro Val Pro Thr Pro Pro Pro Thr Pro Ala Asp Tyr 
                165                 170                 175     


Asp Glu Asp Asp Asn Asp Glu Gly Glu Asp Glu Ser Leu Ala Gly Thr 
            180                 185                 190         


Pro Ala Ser Gly Thr Pro Arg Leu Pro Pro Pro Pro Ala Pro Pro Arg 
        195                 200                 205             


Ser Trp Pro Ser Ala Pro Glu Val Ser His Val Arg Gly Val Thr Val 
    210                 215                 220                 


Arg Met Glu Thr Pro Glu Ala Ile Leu Phe Ser Pro Gly Glu Thr Phe 
225                 230                 235                 240 


Ser Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gln Thr Tyr 
                245                 250                 255     


Ser Met Asp Val Val Trp Leu Arg Phe Asp Val Pro Thr Ser Cys Ala 
            260                 265                 270         


Glu Met Arg Ile Tyr Glu Ser Cys Leu Tyr His Pro Gln Leu Pro Glu 
        275                 280                 285             


Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Ala Ser Thr Trp Thr Ser 
    290                 295                 300                 


Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Asn Pro Pro 
305                 310                 315                 320 


Pro Arg Cys Ser Ala Glu Ala His Met Glu Pro Val Pro Gly Leu Ala 
                325                 330                 335     


Trp Gln Ala Ala Ser Val Asn Leu Glu Phe Arg Asp Ala Ser Pro Gln 
            340                 345                 350         


His Ser Gly Leu Tyr Leu Cys Val Val Tyr Val Asn Asp His Ile His 
        355                 360                 365             


Ala Trp Gly His Ile Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala 
    370                 375                 380                 


Val Val Glu Gln Pro Leu Pro Gln Arg Gly Ala Asp Leu Ala Glu Pro 
385                 390                 395                 400 


Thr His Pro His Val Gly Ala Pro Pro His Ala Pro Pro Thr His Gly 
                405                 410                 415     


Ala Leu Arg Leu 
            420 


<210>  8
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV1 gI ectodomain

<400>  8

Met Pro Cys Arg Pro Leu Gln Gly Leu Val Leu Val Gly Leu Trp Val 
1               5                   10                  15      


Cys Ala Thr Ser Leu Val Val Arg Gly Pro Thr Val Ser Leu Val Ser 
            20                  25                  30          


Asn Ser Phe Val Asp Ala Gly Ala Leu Gly Pro Asp Gly Val Val Glu 
        35                  40                  45              


Glu Asp Leu Leu Ile Leu Gly Glu Leu Arg Phe Val Gly Asp Gln Val 
    50                  55                  60                  


Pro His Thr Thr Tyr Tyr Asp Gly Gly Val Glu Leu Trp His Tyr Pro 
65                  70                  75                  80  


Met Gly His Lys Cys Pro Arg Val Val His Val Val Thr Val Thr Ala 
                85                  90                  95      


Cys Pro Arg Arg Pro Ala Val Ala Phe Ala Leu Cys Arg Ala Thr Asp 
            100                 105                 110         


Ser Thr His Ser Pro Ala Tyr Pro Thr Leu Glu Leu Asn Leu Ala Gln 
        115                 120                 125             


Gln Pro Leu Leu Arg Val Gln Arg Ala Thr Arg Asp Tyr Ala Gly Val 
    130                 135                 140                 


Tyr Val Leu Arg Val Trp Val Gly Asp Ala Pro Asn Ala Ser Leu Phe 
145                 150                 155                 160 


Val Leu Gly Met Ala Ile Ala Ala Glu Gly Thr Leu Ala Tyr Asn Gly 
                165                 170                 175     


Ser Ala Tyr Gly Ser Cys Asp Pro Lys Leu Leu Pro Ser Ser Ala Pro 
            180                 185                 190         


Arg Leu Ala Pro Ala Ser Val Tyr Gln Pro Ala Pro Asn Gln Ala Ser 
        195                 200                 205             


Thr Pro Ser Thr Thr Thr Ser Thr Pro Ser Thr Thr Ile Pro Ala Pro 
    210                 215                 220                 


Ser Thr Thr Ile Pro Ala Pro Gln Ala Ser Thr Thr Pro Phe Pro Thr 
225                 230                 235                 240 


Gly Asp Pro Lys Pro Gln Pro Pro Gly Val Asn His Glu Pro Pro Ser 
                245                 250                 255     


Asn Ala Thr Arg Ala Thr Arg Asp Ser Arg Tyr Ala Leu Thr 
            260                 265                 270 


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 VH

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Tyr Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 HCDR1

<400>  10

Asn Tyr Leu Ile Glu 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 HCDR2

<400>  11

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 HCDR3

<400>  12

Ser Arg Gly Tyr Pro Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3,21, VH

<400>  13

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Val Glu Gly Asp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3,21 HCDR1

<400>  14

Glu Tyr Thr Met His 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3,21 HCDR2

<400>  15

Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3,21 HCDR3

<400>  16

Ser Leu Val Glu Gly Asp Phe Ala Tyr 
1               5                   


<210>  17
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 VH

<400>  17

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Phe Leu Pro Tyr Tyr Gly Ser Pro Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 HCDR1

<400>  18

Asp Phe Tyr Met Glu 
1               5   


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 HCDR2

<400>  19

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 HCDR3

<400>  20

Asp Phe Leu Pro Tyr Tyr Gly Ser Pro Trp Phe Ala Tyr 
1               5                   10              


<210>  21
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 VH

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Phe Ile Thr Thr Val Val Ala Thr Asp Tyr Tyr Ala 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125     


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 HCDR1

<400>  22

Gly Tyr Asn Met Asn 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 HCDR2

<400>  23

Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 HCDR3

<400>  24

Ser Arg Phe Ile Thr Thr Val Val Ala Thr Asp Tyr Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 VH

<400>  25

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Asn Tyr Gly Asn Pro Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 HCDR1

<400>  26

Asp Phe Tyr Met Glu 
1               5   


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 HCDR2

<400>  27

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 HCDR3

<400>  28

Glu Asn Tyr Gly Asn Pro Ala Met Asp Tyr 
1               5                   10  


<210>  29
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12,13 VH

<400>  29

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Ile Thr Ser Leu His Asn Tyr Val Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12,13 HCDR1

<400>  30

Ser Tyr Gly Val His 
1               5   


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12,13 HCDR2

<400>  31

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12,13 HCDR3

<400>  32

Gly Gly Ile Thr Ser Leu His Asn Tyr Val Met Asp Tyr 
1               5                   10              


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 VH

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Ser Ala Gly Asn Tyr Tyr Gly Ser Ser Tyr Glu Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 HCDR1

<400>  34

Ser Tyr Trp Ile Glu 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 HCDR2

<400>  35

Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 HCDR3

<400>  36

Gly Ser Ala Gly Asn Tyr Tyr Gly Ser Ser Tyr Glu Ala Met Asp Tyr 
1               5                   10                  15      


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 VH

<400>  37

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Pro Asp Leu Tyr Tyr Asp Ser Pro Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 HCDR1

<400>  38

Ser Tyr Gly Val Ser 
1               5   


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 HCDR2

<400>  39

Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser 
1               5                   10                  15      


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 HCDR3

<400>  40

Pro Asp Leu Tyr Tyr Asp Ser Pro Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  41
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 VH

<400>  41

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Leu Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 HCDR1

<400>  42

Arg Tyr Trp Met Ser 
1               5   


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 HCDR2

<400>  43

Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 HCDR3

<400>  44

Pro Leu Met Asp Tyr 
1               5   


<210>  45
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 VH

<400>  45

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Ser Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Tyr Gly Tyr Val Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 HCDR1

<400>  46

Ser Tyr Gly Val His 
1               5   


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 HCDR2

<400>  47

Val Ile Trp Ala Gly Gly Ser Ser Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 HCDR3

<400>  48

Asp Gly Tyr Gly Tyr Val Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  49
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 VH

<400>  49

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Pro Tyr Trp Gly Gln Gly Thr Ser Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 HCDR1

<400>  50

Asn Tyr Trp Ile Gly 
1               5   


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 HCDR2

<400>  51

Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 HCDR3

<400>  52

Asp Gly Tyr Ser Pro Tyr 
1               5       


<210>  53
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 VH

<400>  53

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Tyr Gly Asp Ala Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Thr Val Val Ala Asp Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 HCDR1

<400>  54

Asp Tyr Ala Met His 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 HCDR2

<400>  55

Val Ile Ser Thr Tyr Tyr Gly Asp Ala Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 HCDR3

<400>  56

Arg Gly Ile Thr Val Val Ala Asp Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  57
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 VH

<400>  57

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser His Tyr Gly Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 HCDR1

<400>  58

Asn Tyr Leu Ile Glu 
1               5   


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 HCDR2

<400>  59

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 HCDR3

<400>  60

Ser His Tyr Gly Asn Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  61
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 VH

<400>  61

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Phe Tyr Tyr Tyr Gly Ser Arg Gly Gly Ile Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 HCDR1

<400>  62

Asp Tyr Tyr Met Lys 
1               5   


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 HCDR2

<400>  63

Asp Ile Asn Pro Asn Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 HCDR3

<400>  64

Arg Gly Phe Tyr Tyr Tyr Gly Ser Arg Gly Gly Ile Met Asp Tyr 
1               5                   10                  15  


<210>  65
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 VH

<400>  65

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Asp Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Gly Asn Pro Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 HCDR1

<400>  66

Asp Tyr Tyr Met Tyr 
1               5   


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 HCDR2

<400>  67

Tyr Ile Ser Asn Gly Gly Asp Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 HCDR3

<400>  68

Ser Tyr Tyr Gly Asn Pro Phe Pro Tyr 
1               5                   


<210>  69
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 VH

<400>  69

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Asp Gly Tyr Lys Phe Phe Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 HCDR1

<400>  70

Ser Tyr Gly Val His 
1               5   


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 HCDR2

<400>  71

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 HCDR3

<400>  72

Asp Gly Tyr Lys Phe Phe Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  73
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 VH

<400>  73

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Pro Gly Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 HCDR1

<400>  74

Asp Tyr Asn Met His 
1               5   


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 HCDR2

<400>  75

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 HCDR3

<400>  76

Pro Gly Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  77
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 VH

<400>  77

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Ser Tyr Tyr Gly Asp Leu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 HCDR1

<400>  78

Ser Tyr Thr Met Ser 
1               5   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 HCDR2

<400>  79

Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 HCDR3

<400>  80

Gly Val Ser Tyr Tyr Gly Asp Leu Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  81
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 VH

<400>  81

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Tyr Gly Tyr Asp Glu Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 HCDR1

<400>  82

Asn Tyr Gly Met Asn 
1               5   


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 HCDR2

<400>  83

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 HCDR3

<400>  84

Ser Leu Tyr Gly Tyr Asp Glu Gly Tyr Phe Asp Val 
1               5                   10          


<210>  85
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 VH

<400>  85

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Leu Arg Arg Asp Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 HCDR1

<400>  86

Asn Tyr Leu Ile Glu 
1               5   


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 HCDR2

<400>  87

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 HCDR3

<400>  88

Ser Gly Leu Arg Arg Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  89
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 VH

<400>  89

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asn Trp Asp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 HCDR1

<400>  90

Ser Tyr Gly Val His 
1               5   


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 HCDR2

<400>  91

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 HCDR3

<400>  92

Glu Gly Asn Trp Asp Asp Phe Asp Tyr 
1               5                   


<210>  93
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 VH

<400>  93

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Tyr Gly Ser Ser Phe Glu Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 HCDR1

<400>  94

Ser Tyr Thr Met Ser 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 HCDR2

<400>  95

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 HCDR3

<400>  96

Gly Gly Tyr Gly Ser Ser Phe Glu Asn Tyr Phe Asp Tyr 
1               5                   10              


<210>  97
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 VH

<400>  97

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Ile Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Arg Tyr Leu Val His Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 HCDR1

<400>  98

Gly Tyr Asn Met Asn 
1               5   


<210>  99
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 HCDR2

<400>  99

Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Ile Arg Tyr Asn Gln Lys Phe 
1               5                   10                  15      


Lys Gly 
        


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 HCDR3

<400>  100

Glu Asp Arg Tyr Leu Val His Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  101
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 VH

<400>  101

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asn Tyr Gly Ser Arg Pro Pro Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 HCDR1

<400>  102

Ser Tyr Thr Met Ser 
1               5   


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 HCDR2

<400>  103

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 HCDR3

<400>  104

Asn Tyr Gly Ser Arg Pro Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  105
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 VH

<400>  105

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Pro Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 HCDR1

<400>  106

Asp Tyr Tyr Met Ser 
1               5   


<210>  107
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 HCDR2

<400>  107

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 HCDR3

<400>  108

Asp Arg Pro Gly Phe Asp Tyr 
1               5           


<210>  109
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 VH

<400>  109

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Gly Phe Tyr Tyr Arg Tyr Asp Gly Gly Arg Arg Tyr 
            100                 105                 110         


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 HCDR1

<400>  110

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 HCDR2

<400>  111

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  112
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 HCDR3

<400>  112

Arg Gly Phe Tyr Tyr Arg Tyr Asp Gly Gly Arg Arg Tyr Tyr Tyr Ala 
1               5                   10                  15      


Met Asp Tyr 
            


<210>  113
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 VL

<400>  113

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  114
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 LCDR1

<400>  114

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 LCDR2

<400>  115

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 2 LCDR3

<400>  116

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  117
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 VL

<400>  117

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3,21 LCDR1

<400>  118

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 LCDR2

<400>  119

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 LCDR3

<400>  120

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 VL

<400>  121

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 LCDR1

<400>  122

Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His 
1               5                   10      


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 LCDR2

<400>  123

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 5 LCDR3

<400>  124

Gln Asn Gly His Ser Phe Pro Tyr Thr 
1               5                   


<210>  125
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 VL

<400>  125

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 LCDR1

<400>  126

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 LCDR2

<400>  127

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 9 LCDR3

<400>  128

Gln Gln Tyr Tyr Ser Tyr Pro Pro Thr 
1               5                   


<210>  129
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 VL

<400>  129

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 LCDR1

<400>  130

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 LCDR2

<400>  131

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10 LCDR3

<400>  132

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  133
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 LV

<400>  133

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Ser Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 LCDR1

<400>  134

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12,13 LCDR2

<400>  135

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 LCDR3

<400>  136

Gln Gln Ser Arg Lys Val Pro Ser Thr 
1               5                   


<210>  137
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 VL

<400>  137

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  138
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 LCDR1

<400>  138

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 LCDR2

<400>  139

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 14 LCDR3

<400>  140

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  141
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 VL

<400>  141

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  142
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 LCDR1

<400>  142

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 LCDR2

<400>  143

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 15 LCDR3

<400>  144

Gln His Phe Trp Ser Thr Pro Trp Thr 
1               5                   


<210>  145
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 VL

<400>  145

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Lys Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  146
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 LCDR1

<400>  146

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Lys 
1               5                   10                  15      


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 LCDR2

<400>  147

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 16 LCDR3

<400>  148

Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  149
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 VL

<400>  149

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  150
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 LCDR1

<400>  150

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 LCDR2

<400>  151

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 17 LCDR3

<400>  152

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  153
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 VL

<400>  153

Thr Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 LCDR1

<400>  154

Lys Ala Ser Gln Ser Val Ser Asn Ala Val Ala 
1               5                   10      


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 LCDR2

<400>  155

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 18 LCDR3

<400>  156

Gln Gln Asp Tyr Thr Ser Pro Phe Thr 
1               5                   


<210>  157
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 VL

<400>  157

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 LCDR1

<400>  158

Ser Ala Ser Ser Ser Val Thr Tyr Met His 
1               5                   10  


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 LCDR2

<400>  159

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 19 LCDR3

<400>  160

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  161
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 VL

<400>  161

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 LCDR1

<400>  162

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 LCDR2

<400>  163

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  164
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 20 LCDR3

<400>  164

Gln Gln Asn Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  165
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 VL

<400>  165

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  166
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 LCDR1

<400>  166

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 LCDR2

<400>  167

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 24 LCDR3

<400>  168

His Gln Tyr Leu Ser Ser Tyr 
1               5           


<210>  169
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 VL

<400>  169

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  170
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 LCDR1

<400>  170

Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 LCDR2

<400>  171

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 34 LCDR3

<400>  172

Gln Gln Tyr Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  173
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 VL

<400>  173

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  174
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 LCDR1

<400>  174

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 LCDR2

<400>  175

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  176
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 LCDR3

<400>  176

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  177
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 VL

<400>  177

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ser Thr Tyr Tyr Cys His His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  178
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 LCDR1

<400>  178

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 LCDR2

<400>  179

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 37 LCDR3

<400>  180

His His Ser Arg Glu Leu Pro Arg Thr 
1               5                   


<210>  181
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 VL

<400>  181

Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Asn Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu His Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Gln Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  182
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 LCDR1

<400>  182

Arg Ser Ser Gln Ser Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  183
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 LCDR2

<400>  183

Gly Ile Ser Asn Arg Phe Ser 
1               5           


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 39 LCDR3

<400>  184

Leu Gln Gly Thr His Gln Pro Trp Thr 
1               5                   


<210>  185
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 VL

<400>  185

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 LCDR1

<400>  186

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 LCDR2

<400>  187

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 40 LCDR3

<400>  188

Gln His Phe Trp Ser Thr Pro Tyr Thr 
1               5                   


<210>  189
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 VL

<400>  189

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  190
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 LCDR1

<400>  190

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 LCDR2

<400>  191

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 41 LCDR3

<400>  192

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  193
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 VL

<400>  193

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  194
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 LCDR1

<400>  194

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 LCDR2

<400>  195

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 LCDR3

<400>  196

Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  197
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 VL

<400>  197

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 LCDR1

<400>  198

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu His 
1               5                   10      


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 LCDR2

<400>  199

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 LCDR3

<400>  200

Gln Gln Ser Asn Ser Trp Pro Phe Thr 
1               5                   


<210>  201
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 VL

<400>  201

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Ser Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  202
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 LCDR1

<400>  202

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 LCDR2

<400>  203

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 43 LCDR3

<400>  204

Lys Gln Ser Tyr Asn Leu Pro Leu Thr 
1               5                   


<210>  205
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 VL

<400>  205

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 LCDR1

<400>  206

Ser Ala Ser Ser Ser Ile Ser Tyr Met His 
1               5                   10  


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 LCDR2

<400>  207

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 44 LCDR3

<400>  208

His Gln Arg Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  209
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 VL

<400>  209

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  210
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 LCDR1

<400>  210

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 LCDR2

<400>  211

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  212
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 45 LCDR3

<400>  212

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  213
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 VL

<400>  213

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  214
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 LCDR1

<400>  214

Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  215
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 LCDR2

<400>  215

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 47 LCDR3

<400>  216

Gln Gln Asn Asn Glu Asp Pro Pro Trp Thr 
1               5                   10  


<210>  217
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 VL

<400>  217

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Gly Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 LCDR1

<400>  218

Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 LCDR2

<400>  219

Phe Ala Ser Glu Ser Ile Ser 
1               5           


<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 48 LCDR3

<400>  220

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  221
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 VH

<400>  221
caggtccagc tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg       60

tcctgcaagg cttctggata cgccttcact aattacttga tagagtgggt aaagcagagg      120

cctggacagg gccttgagtg gattggagtg attaatcctg gaagtggtgg tactaactac      180

aatgagaagt tcaagggcaa ggcaacactg actgcagaca aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgatgac tctgcggtct atttctgtgc gagatcacgg      300

ggttacccct atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  222
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 HCDR1

<400>  222
aattacttga tagag                                                        15


<210>  223
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 HCDR2

<400>  223
gtgattaatc ctggaagtgg tggtactaac tacaatgaga agttcaaggg c                51


<210>  224
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 HCDR3

<400>  224
tcacggggtt acccctatgc tatggactac                                        30


<210>  225
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 VH

<400>  225
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaaga cctctggata cacattcact gaatacacca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggaggt attaatccta acaatggtgg tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggat tctgcagtct attactgtgc aagatcgtta      300

gtagaggggg actttgctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210>  226
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 HCDR1

<400>  226
gaatacacca tgcac                                                        15


<210>  227
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 HCDR2

<400>  227
ggtattaatc ctaacaatgg tggtactagc tacaaccaga agttcaaggg c                51


<210>  228
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 HCDR3

<400>  228
tcgttagtag agggggactt tgcttac                                           27


<210>  229
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 VH

<400>  229
gaggtgaagc tggtggaatc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcagt gatttctaca tggagtgggt ccgccagcct      120

ccagggaaga gactggagtg gattgctgca agtagaaaca aagctaatga ttatacaaca      180

gagtacagtg catctgtgaa gggtcggttc atcgtctcca gagacacttc ccaaagcatc      240

ctctaccttc agatgaatgc cctgagagct gaggacactg ccatttatta ctgtgcaaga      300

gatttcctcc cttactacgg tagtccctgg tttgcttact ggggccaagg gactctggtc      360

actgtctctg ca                                                          372


<210>  230
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 HCDR1

<400>  230
gatttctaca tggag                                                        15


<210>  231
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 HCDR2

<400>  231
gcaagtagaa acaaagctaa tgattataca acagagtaca gtgcatctgt gaagggt          57


<210>  232
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 HCDR3

<400>  232
gatttcctcc cttactacgg tagtccctgg tttgcttac                              39


<210>  233
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 VH

<400>  233
gaggtccagc tgcagcagtc tggacctgag ctggagaagc ctggcgcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctacaaca tgaactgggt gaagcagagc      120

aatggaaaga gccttgagtg gattggaaat attgatcctt actatggtgg tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actctagaca aatcctccag cacagcctac      240

atgcagctca agagcctgac atctgaggac tctgcagtct attactgtgc aagatcgcgg      300

tttattacta cggtagtagc taccgattac tatgctatgg actactgggg tcaaggaacc      360

tcagtcaccg tctcctca                                                    378


<210>  234
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 HCDR1

<400>  234
ggctacaaca tgaac                                                        15


<210>  235
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 HCDR2

<400>  235
aatattgatc cttactatgg tggtactagc tacaaccaga agttcaaggg c                51


<210>  236
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 HCDR3

<400>  236
tcgcggttta ttactacggt agtagctacc gattactatg ctatggacta c                51


<210>  237
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 VH

<400>  237
gaggtgaagc tggtggaatc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcagt gatttctaca tggagtgggt ccgccagcct      120

ccagggaaga gactggagtg gattgctgca agtagaaaca aagctaatga ttatacaaca      180

gagtacagtg catctgtgaa gggtcggttc atcgtctcca gagacacttc ccaaagcatc      240

ctctaccttc agatgaatgc cctgagagct gaggacactg ccatttatta ctgtgcaaga      300

gagaactatg gtaaccccgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  238
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 HCDR1

<400>  238
gatttctaca tggag                                                        15


<210>  239
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 HCDR2

<400>  239
gcaagtagaa acaaagctaa tgattataca acagagtaca gtgcatctgt gaagggt          57


<210>  240
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 HCDR3

<400>  240
gagaactatg gtaaccccgc tatggactac                                        30


<210>  241
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 VH

<400>  241
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc agctatggtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatgggctg gtggaagcac aaattataat      180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact tctgtgccag aggggggatt      300

acgtcccttc ataactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  242
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 HCDR1

<400>  242
agctatggtg tacac                                                        15


<210>  243
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 HCDR2

<400>  243
gtaatatggg ctggtggaag cacaaattat aattcggctc tcatgtcc                    48


<210>  244
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 HCDR3

<400>  244
ggggggatta cgtcccttca taactatgtt atggactac                              39


<210>  245
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 VH

<400>  245
caggttcagc tgcagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt agctactgga tagagtgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaagtggtag tactaactac      180

aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgccgtct attactgtgc aagtgggagt      300

gcaggtaatt actacggtag tagctacgag gctatggact actggggtca aggaacctca      360

gtcaccgtct cctca                                                       375


<210>  246
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 HCDR1

<400>  246
agctactgga tagag                                                        15


<210>  247
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 HCDR2

<400>  247
gagattttac ctggaagtgg tagtactaac tacaatgaga agttcaaggg c                51


<210>  248
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 HCDR3

<400>  248
gggagtgcag gtaattacta cggtagtagc tacgaggcta tggactac                    48


<210>  249
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 VH

<400>  249
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctcagggtt ctcattaacc agctatggtg taagctgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatggggtg acgggagcac aaattatcat      180

tcagctctca tatccagact gagcatcagc aaggataact ccaagagcca agttttctta      240

aaactgaaca gtctgcaaac tgatgacaca gccacgtact actgtgccaa accggatctc      300

tactatgatt ctccctatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  250
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 HCDR1

<400>  250
agctatggtg taagc                                                        15


<210>  251
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 HCDR2

<400>  251
gtaatatggg gtgacgggag cacaaattat cattcagctc tcatatcc                    48


<210>  252
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 HCDR3

<400>  252
ccggatctct actatgattc tccctatgct atggactac                              39


<210>  253
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 VH

<400>  253
gaggtgaagc ttctcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc       60

tcctgtgcag cctcaggatt cgattttagt agatactgga tgagttgggt ccggcaggct      120

ccagggaaag ggctagaatg gattggagaa attaatccag atagcagtac gataaactat      180

acgccatctc taaaggataa attcatcatc tccagagaca acgccaaaaa tacgctgtac      240

ctgcaaatga gcaaagtgag atctgaggac acagcccttt attactgtgc aagacccctt      300

atggactact ggggtcaagg aacctcagtc accgtctcct ca                         342


<210>  254
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 HCDR1

<400>  254
agatactgga tgagt                                                        15


<210>  255
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 HCDR2

<400>  255
gaaattaatc cagatagcag tacgataaac tatacgccat ctctaaagga t                51


<210>  256
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 HCDR3

<400>  256
ccccttatgg actac                                                        15


<210>  257
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 VH

<400>  257
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc agctatggtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatgggctg gtggaagctc aaattataat      180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag agatggctac      300

ggctacgttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  258
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 HCDR1

<400>  258
agctatggtg tacac                                                        15


<210>  259
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 HCDR2

<400>  259
gtaatatggg ctggtggaag ctcaaattat aattcggctc tcatgtcc                    48


<210>  260
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 HCDR3

<400>  260
gatggctacg gctacgttta ctatgctatg gactac                                 36


<210>  261
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 VH

<400>  261
caggtccagc tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaagatg       60

tcctgcaagg ctgctggata caccttcact aactattgga taggttgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagat atttaccctg gaggtggtta tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca catcctccag tacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgccatct attactgtgc aagagacggt      300

tactccccct actggggcca aggcacctct ctcacagtct cctca                      345


<210>  262
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 HCDR1

<400>  262
aactattgga taggt                                                        15


<210>  263
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 HCDR2

<400>  263
gatatttacc ctggaggtgg ttatactaag tacaatgaga agttcaaggg c                51


<210>  264
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 HCDR3

<400>  264
gacggttact ccccctac                                                     18


<210>  265
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 VH

<400>  265
caggtccagc tgcagcagtc tggggctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttctggcta cacattcact gattatgcta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt actatggtga tgctaggtac      180

aaccagaagt tcaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagactgac atctgaggat tctgccatct attactgtgc aagacggggg      300

attacggtag tagccgacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  266
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 HCDR1

<400>  266
gattatgcta tgcac                                                        15


<210>  267
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 HCDR2

<400>  267
gttattagta cttactatgg tgatgctagg tacaaccaga agttcaaggg c                51


<210>  268
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 HCDR3

<400>  268
cgggggatta cggtagtagc cgactatgct atggactac                              39


<210>  269
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 VH

<400>  269
caggtccagc tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg       60

tcctgcaagg cttctggata cgccttcact aattacttga tagagtgggt aaagcagagg      120

cctggacagg gccttgagtg gattggagtg attaatcctg gaagtggtgg tactaactac      180

aatgagaagt tcaagggcaa ggcaacactg actgcagaca aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgatgac tctgcggttt atttctgtgc aagatcgcac      300

tatggtaact actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  270
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 HCDR1

<400>  270
aattacttga tagag                                                        15


<210>  271
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 HCDR2

<400>  271
gtgattaatc ctggaagtgg tggtactaac tacaatgaga agttcaaggg c                51


<210>  272
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 HCDR3

<400>  272
tcgcactatg gtaactacta tgctatggac tac                                    33


<210>  273
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 VH

<400>  273
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata caccttcact gactactaca tgaagtgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtga tactttctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagaagaggt      300

ttttattact acggtagtag agggggtatt atggactact ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  274
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 HCDR1

<400>  274
gactactaca tgaag                                                        15


<210>  275
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 HCDR2

<400>  275
gatattaatc ctaacaatgg tgatactttc tacaaccaga agttcaaggg c                51


<210>  276
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 HCDR3

<400>  276
agaggttttt attactacgg tagtagaggg ggtattatgg actac                       45


<210>  277
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 VH

<400>  277
gaagtgaagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcaa cctctggatt cactttcagt gactattaca tgtattgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatac attagtaatg gtggtgatag cacctattat      180

ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gccgtctgaa gtctgaggac acagccatgt attactgtgc aagatcctac      300

tatggtaacc cttttcctta ctggggccag gggactctgg tcactgtctc tgca            354


<210>  278
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 HCDR1

<400>  278
gactattaca tgtat                                                        15


<210>  279
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 HCDR2

<400>  279
tacattagta atggtggtga tagcacctat tatccagaca ctgtaaaggg c                51


<210>  280
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 HCDR3

<400>  280
tcctactatg gtaacccttt tccttac                                           27


<210>  281
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 VH

<400>  281
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc agctatggtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatgggctg gtggaagcac aaattataat      180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccac tgatggttac      300

aagttttttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  282
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 HCDR1

<400>  282
agctatggtg tacac                                                        15


<210>  283
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 HCDR2

<400>  283
gtaatatggg ctggtggaag cacaaattat aattcggctc tcatgtcc                    48


<210>  284
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 HCDR3

<400>  284
gatggttaca agttttttta ctatgctatg gactac                                 36


<210>  285
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 VH

<400>  285
gaggtccagc ttcagcagtc aggacctgag ctggtgaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat atttatcctt acaatggtgg tactggctac      180

aaccagaaat tcaagaccaa ggccacattg actgtagaca attcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aatccctggg      300

tattactatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  286
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 HCDR1

<400>  286
gactacaaca tgcac                                                        15


<210>  287
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 HCDR2

<400>  287
tatatttatc cttacaatgg tggtactggc tacaaccaga aattcaagac c                51


<210>  288
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 HCDR3

<400>  288
cctgggtatt actatgctat ggactac                                           27


<210>  289
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 VH

<400>  289
gaagtgaagc tggtggagtc tgggggaggt ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatac attagtaatg gtggtggtag cacctactat      180

ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acggccatgt attactgtgc aagaggggta      300

tcctactatg gtgacctgta ctactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  290
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 HCDR1

<400>  290
agctatacca tgtct                                                        15


<210>  291
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 HCDR2

<400>  291
tacattagta atggtggtgg tagcacctac tatccagaca ctgtaaaggg c                51


<210>  292
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 HCDR3

<400>  292
ggggtatcct actatggtga cctgtactac tttgactac                              39


<210>  293
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 VH

<400>  293
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagatccctc      300

tatggttacg acgaggggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  294
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 HCDR1

<400>  294
aactatggaa tgaac                                                        15


<210>  295
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 HCDR2

<400>  295
tggataaaca cctacactgg agagccaaca tatgctgatg acttcaaggg a                51


<210>  296
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 HCDR3

<400>  296
tccctctatg gttacgacga ggggtacttc gatgtc                                 36


<210>  297
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 VH

<400>  297
caggtccagc tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg       60

tcctgcaagg cttctggata cgccttcact aattacttga tagagtgggt aaagcagagg      120

cctggacagg gccttgagtg gattggagtg attaatcctg gaagtggtgg tactaactac      180

aatgagaagt tcaagggcaa ggcaacactg actgcagaca aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgatgac tctgcggtct atttctgtgc aagatcggga      300

ttacgacggg attactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  298
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 HCDR1

<400>  298
aattacttga tagag                                                        15


<210>  299
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 HCDR2

<400>  299
gtgattaatc ctggaagtgg tggtactaac tacaatgaga agttcaaggg c                51


<210>  300
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 HCDR3

<400>  300
tcgggattac gacgggatta ctatgctatg gactac                                 36


<210>  301
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 VJ

<400>  301
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc agctatggtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatgggctg gtggaagcac aaattataat      180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag agagggtaac      300

tgggacgatt ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  302
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 HCDR1

<400>  302
agctatggtg tacac                                                        15


<210>  303
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 HCDR2

<400>  303
gtaatatggg ctggtggaag cacaaattat aattcggctc tcatgtcc                    48


<210>  304
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 HCDR3

<400>  304
gagggtaact gggacgattt tgactac                                           27


<210>  305
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 VH

<400>  305
gacgtgaagt tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtagtta cacctactat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa ggctgaggac acagccatgt attactgtac aagagggggt      300

tacggtagta gcttcgagaa ctactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  306
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 HCDR1

<400>  306
agctatacca tgtct                                                        15


<210>  307
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 HCDR2

<400>  307
accattagta gtggtggtag ttacacctac tatccagaca gtgtgaaggg c                51


<210>  308
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 HCDR3

<400>  308
gggggttacg gtagtagctt cgagaactac tttgactac                              39


<210>  309
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 VH

<400>  309
gaggtccagc tgcagcagtc tggacctgag ctggagaagc ctggcgcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctacaaca tgaactgggt gaagcagagc      120

aatggaaaga gccttgagtg gattggaaat attgaccctt actatggtgg tattaggtac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca agagcctgac atctgaggac tctgcagtct attactgtgc aagagaggat      300

aggtacctag ttcattacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  310
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 HCDR1

<400>  310
ggctacaaca tgaac                                                        15


<210>  311
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 HCDR2

<400>  311
aatattgacc cttactatgg tggtattagg tacaaccaga agttcaaggg c                51


<210>  312
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 HCDR3

<400>  312
gaggataggt acctagttca ttactatgct atggactac                              39


<210>  313
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 VH

<400>  313
gacgtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtagtta cacctactat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtac aagaaactac      300

ggtagtcgac ccccttacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  314
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 HCDR1

<400>  314
agctatacca tgtct                                                        15


<210>  315
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 HCDR2

<400>  315
accattagta gtggtggtag ttacacctac tatccagaca gtgtgaaggg c                51


<210>  316
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 HCDR3

<400>  316
aactacggta gtcgaccccc ttactatgct atggactac                              39


<210>  317
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 VH

<400>  317
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcact gattactaca tgagctgggt ccgccagcct      120

ccaggaaagg cacttgagtg gttgggtttt attagaaaca aagctaatgg ttacacaaca      180

gagtacagtg catctgtgaa gggtcggttc accatctcca gagataattc ccaaagcatc      240

ctctatcttc aaatgaacac cctgagagct gaggacagtg ccacttatta ctgtgcaaga      300

gatcgcccgg gctttgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  318
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 HCDR1

<400>  318
gattactaca tgagc                                                        15


<210>  319
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 HCDR2

<400>  319
tttattagaa acaaagctaa tggttacaca acagagtaca gtgcatctgt gaagggt          57


<210>  320
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 HCDR3

<400>  320
gatcgcccgg gctttgacta c                                                 21


<210>  321
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 VH

<400>  321
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga tgacaagcgc      180

tataacccat ccctgaagag ccggctcaca atctccaagg atacctccag caaccaggta      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catactactg tgctcgaagg      300

gggttctact ataggtacga cggggggcgc cgctattact atgctatgga ctactggggt      360

caaggaacct cagtcaccgt ctcctca                                          387


<210>  322
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 HCDR1

<400>  322
acttctggta tgggtgtgag c                                                 21


<210>  323
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 HCDR2

<400>  323
cacatttact gggatgatga caagcgctat aacccatccc tgaagagc                    48


<210>  324
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 HCDR3

<400>  324
agggggttct actataggta cgacgggggg cgccgctatt actatgctat ggactac          57


<210>  325
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 VL

<400>  325
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  326
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 LCDR1

<400>  326
aaggccagcc aaagtgttga ttatgatggt gatagttata tgaac                       45


<210>  327
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 LCDR2

<400>  327
gctgcatcca atctagaa                                                     18


<210>  328
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 2 LCDR3

<400>  328
cagcaaagta atgaggatcc gtacacg                                           27


<210>  329
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 VL

<400>  329
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagc acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcataaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  330
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 LCDR1

<400>  330
agggccagcc aaagtgtcag cacatctagc tatagttata tgcac                       45


<210>  331
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 LCDR2

<400>  331
tatgcatcca acctagaatc t                                                 21


<210>  332
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 3, 21 LCDR3

<400>  332
cagcacagtt gggagattcc gtacacg                                           27


<210>  333
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 VL

<400>  333
gacattgtga tgactcagtc tccagccacc ctgtctgtga ctccaggaga tagagtctct       60

ctttcctgca gggccagcca gagtattagc gactacttac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaaatat gcttcccaat ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggtcagat ttcactctca gtatcaacag tgtggaacct      240

gaagatgttg gagtgtatta ctgtcaaaat ggtcacagct ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  334
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 LCDR1

<400>  334
agggccagcc agagtattag cgactactta cac                                    33


<210>  335
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 LCDR2

<400>  335
tatgcttccc aatccatctc t                                                 21


<210>  336
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 5 LCDR3

<400>  336
caaaatggtc acagctttcc gtacacg                                           27


<210>  337
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 VL

<400>  337
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

cctcccacgt tcggaggggg gaccaagctg gaaataaaa                             339


<210>  338
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 LCDR1

<400>  338
aagtccagtc agagcctttt atatagtagc aatcaaaaga actacttg                    48


<210>  339
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 LCDR2

<400>  339
tgggcatcca ctagggaatc t                                                 21


<210>  340
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 9 LCDR3

<400>  340
cagcaatatt atagctatcc tcccacg                                           27


<210>  341
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 VL

<400>  341
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  342
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 LCDR1

<400>  342
aaggccagcc aaagtgttga ttatgatggt gatagttata tgaac                       45


<210>  343
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 LCDR2

<400>  343
gctgcatcca atctagaatc t                                                 21


<210>  344
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 10 LCDR3

<400>  344
cagcaaagta atgaggatcc gtacacg                                           27


<210>  345
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12,13 VL

<400>  345
gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctagggca gagagccacc       60

atctcctgca gagccagtga aagtgttgaa tattatggca caagtttaat gcagtggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tctgggacac acttcagcct caacatccat      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccttcg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  346
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 LCDR1

<400>  346
agagccagtg aaagtgttga atattatggc acaagtttaa tgcag                       45


<210>  347
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 LCDR2

<400>  347
gctgcatcca acgtagaatc t                                                 21


<210>  348
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 12, 13 LCDR3

<400>  348
cagcaaagta ggaaggttcc ttcgacg                                           27


<210>  349
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 VL

<400>  349
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttcctctc      300

acgttcggtg ctgggaccaa gctggagctg aaa                                   333


<210>  350
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 LCDR1

<400>  350
agggccagca aaagtgtcag tacatctggc tatagttata tgcac                       45


<210>  351
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 LCDR2

<400>  351
cttgcatcca acctagaatc t                                                 21


<210>  352
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 14 LCDR3

<400>  352
cagcacagta gggagcttcc tctcacg                                           27


<210>  353
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 VL

<400>  353
caggtcctgg cgttgctgct gctgtggctt acaggtgcca gatgtgacat ccagatgact       60

cagtctccag cctccctatc tgcatctgtg ggagaaactg tcaccatcac atgtcgagca      120

agtgggaata ttcacaatta tttagcatgg tatcagcaga aacagggaaa atctcctcag      180

ctcctggtct ataatgcaaa aaccttagca gatggtgtgc catcaaggtt cagtggcagt      240

ggatcaggaa cacaatattc tctcaagatc aacagcctgc agcctgaaga ttttgggagt      300

tattactgtc aacatttttg gagtactccg tggacgttcg gtggaggcac caagctggaa      360

atcaaa                                                                 366


<210>  354
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 LCDR1

<400>  354
cgagcaagtg ggaatattca caattattta gca                                    33


<210>  355
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 LCDR2

<400>  355
aatgcaaaaa ccttagcaga t                                                 21


<210>  356
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 15 LCDR3

<400>  356
caacattttt ggagtactcc gtggacg                                           27


<210>  357
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 VL

<400>  357
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaagtgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  358
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 LCDR1

<400>  358
aagtcaagtc agagcctctt agatagtgat ggaaagacat atttgaag                    48


<210>  359
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 LCDR2

<400>  359
ctggtgtcta aactggactc t                                                 21


<210>  360
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 16 LCDR3

<400>  360
tggcaaggta cacattttcc gtggacg                                           27


<210>  361
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 VL

<400>  361
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcct      300

ttcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  362
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 LCDR1

<400>  362
aggtctagta agagtctcct gcatagtaat ggcaacactt acttgtat                    48


<210>  363
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 LCDR2

<400>  363
cggatgtcca accttgcctc a                                                 21


<210>  364
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 17 LCDR3

<400>  364
atgcaacatc tagaatatcc tttcacg                                           27


<210>  365
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 VL

<400>  365
actattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgctgtag cttggtacca acagaagcca      120

ggccagtctc ctaaactgct gatatactct gcatccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagctc tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatacct ctccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  366
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 LCDR1

<400>  366
aaggccagtc agagtgtgag taatgctgta gct                                    33


<210>  367
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 LCDR2

<400>  367
tctgcatcca atcgctacac t                                                 21


<210>  368
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 18 LCDR3

<400>  368
cagcaggatt atacctctcc attcacg                                           27


<210>  369
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 VL

<400>  369
caaattgttc tcacccagtc tccagcaatc atgtctgctt ctccagggga gaaggtcacc       60

atgtcctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc caccgacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  370
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 LCDR1

<400>  370
agtgccagct caagtgtaac ttacatgcac                                        30


<210>  371
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 LCDR2

<400>  371
gacacatcca aactggcttc t                                                 21


<210>  372
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 19 LCDR3

<400>  372
cagcagtgga gtagtaaccc accgacg                                           27


<210>  373
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 VL

<400>  373
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  374
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 LCDR1

<400>  374
agagccagtg aaagtgttga tagttatggc aatagtttta tgcac                       45


<210>  375
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 LCDR2

<400>  375
cttgcatcca acctagaatc t                                                 21


<210>  376
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 20 LCDR3

<400>  376
cagcaaaata atgaggatcc gtggacg                                           27


<210>  377
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 VL

<400>  377
aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact       60

atgagctgta agtccagtca aagtgtttta tacagttcaa atcagaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctggtg tccctgatcg cttcacaggc agtggatctg ggacagattt tactcttacc      240

atcagcagtg tacaagctga agacctggca gtttattact gtcatcaata cctctcctcg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  378
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 LCDR1

<400>  378
aagtccagtc aaagtgtttt atacagttca aatcagaaga actacttggc                  50


<210>  379
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 LCDR2

<400>  379
tgggcatcca ctagggaatc t                                                 21


<210>  380
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 24 LCDR3

<400>  380
catcaatacc tctcctcgta cacg                                              24


<210>  381
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 VL

<400>  381
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctccagggga aaaggtcacc       60

atgacctgca gggccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

tcaggtgcct cccccaaact ctggatttat agcacatcca acttggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagtgtggag      240

gctgaagatg ctgccactta ttactgccag cagtacagtg gttacccact cacgttcggt      300

gctgggacca agctggagct gaaa                                             324


<210>  382
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 LCDR1

<400>  382
agggccagct caagtgtaag ttccagttac ttgcac                                 36


<210>  383
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 LCDR2

<400>  383
agcacatcca acttggcttc t                                                 21


<210>  384
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 34 LCDR3

<400>  384
cagcagtaca gtggttaccc actcacg                                           27


<210>  385
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 VL

<400>  385
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  386
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 LCDR1

<400>  386
aggtctagta agagtctcct gcatagtaat ggcaacactt acttgtat                    48


<210>  387
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 LCDR2

<400>  387
cggatgtcca accttgcctc a                                                 21


<210>  388
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 35, 36 LCDR3

<400>  388
atgcaacatc tagaatatcc attcacg                                           27


<210>  389
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 VL

<400>  389
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc ttcaacctat tactgtcatc acagtaggga acttcctcgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  390
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 LCDR1

<400>  390
agggccagca aaagtgtcag tacatctggc tatagttata tgcac                       45


<210>  391
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 LCDR2

<400>  391
cttgcatcca acctagaatc t                                                 21


<210>  392
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 37 LCDR3

<400>  392
catcacagta gggaacttcc tcggacg                                           27


<210>  393
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 VL

<400>  393
gatgttgtgg tgactcaaac tccactctcc ctgcctgtca gctttggaga tcaagtttct       60

atctcttgca ggtctagtca gagtcttgca aacagttatg ggaacaccta tttgtcttgg      120

tacctgcaca agcctggcca gtctccacag ctcctcatct atgggatttc caacagattt      180

tctggggtgc cagacaggtt cagtggcagt ggttcaggga cagatttcac actcaagatc      240

agcacaataa agcctgagga cttgggaatg tattactgct tacaaggtac acatcagccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  394
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 LCDR1

<400>  394
aggtctagtc agagtcttgc aaacagttat gggaacacct atttgtct                    48


<210>  395
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 LCDR2

<400>  395
gggatttcca acagattttc t                                                 21


<210>  396
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 39 LCDR3

<400>  396
ttacaaggta cacatcagcc gtggacg                                           27


<210>  397
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 VL

<400>  397
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat ttttggagta ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  398
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 LCDR1

<400>  398
cgagcaagtg ggaatattca caattattta gca                                    33


<210>  399
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 LCDR2

<400>  399
aatgcaaaaa ccttagcaga t                                                 21


<210>  400
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 40 LCDR3

<400>  400
caacattttt ggagtactcc gtacacg                                           27


<210>  401
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 VL

<400>  401
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  402
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 LCDR1

<400>  402
aaggccagcc aaagtgttga ttatgatggt gatagttata tgaac                       45


<210>  403
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 LCDR2

<400>  403
gctgcatcca atctagaatc t                                                 21


<210>  404
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 41 LCDR3

<400>  404
cagcaaagta atgaggatcc gtggacg                                           27


<210>  405
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 VL

<400>  405
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  406
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 LCDR1

<400>  406
aagtcaagtc agagcctctt agatagtgat ggaaagacat atttgaat                    48


<210>  407
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 LCDR2

<400>  407
ctggtgtcta aactggactc t                                                 21


<210>  408
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L1 LCDR3

<400>  408
tggcaaggta cacattttcc gtggacg                                           27


<210>  409
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 VL

<400>  409
gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaga tagagtcagt       60

ctttcctgca gggccagtca aagtattagc aactacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      240

gaagattttg gaatgtattt ctgtcaacag agtaacagct ggccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  410
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 LCDR1

<400>  410
agggccagtc aaagtattag caactaccta cac                                    33


<210>  411
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 LCDR2

<400>  411
tatgcttccc agtccatctc t                                                 21


<210>  412
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 42 - L2 LCDR3

<400>  412
caacagagta acagctggcc attcacg                                           27


<210>  413
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 VL

<400>  413
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctccc aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattcct gcaagcaatc ttataatctt      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  414
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 LCDR1

<400>  414
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210>  415
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 LCDR2

<400>  415
tgggcatcca ctagggaatc t                                                 21


<210>  416
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 43 LCDR3

<400>  416
aagcaatctt ataatcttcc gctcacg                                           27


<210>  417
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 VL

<400>  417
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtataagt tacatgcact ggtaccagca gaagccaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttat tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccatcagcgg agtagttacc cgtacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  418
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 LCDR1

<400>  418
agtgccagct caagtataag ttacatgcac                                        30


<210>  419
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 LCDR2

<400>  419
gacacatcca aactggcttc t                                                 21


<210>  420
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 44 LCDR3

<400>  420
catcagcgga gtagttaccc gtacacg                                           27


<210>  421
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 VL

<400>  421
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  422
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 LCDR1

<400>  422
agggccagca aaagtgtcag tacatctggc tatagttata tgcac                       45


<210>  423
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 LCDR2

<400>  423
cttgcatcca acctagaatc t                                                 21


<210>  424
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 45 LCDR3

<400>  424
cagcacagta gggagcttcc gtacacg                                           27


<210>  425
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 VL

<400>  425
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttttggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggatcctccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  426
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 LCDR1

<400>  426
agagccagtg aaagtgttga tagttttggc aatagtttta tgcac                       45


<210>  427
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 LCDR2

<400>  427
cttgcatcca acctagaatc t                                                 21


<210>  428
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 47 LCDR3

<400>  428
cagcaaaata atgaggatcc tccgtggacg                                        30


<210>  429
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 VL

<400>  429
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaggaaca      120

aatggttctc caaggcttct cataaagttt gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtaatagct ggccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  430
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 LCDR1

<400>  430
agggccagtc agagcattgg cacaagcata cac                                    33


<210>  431
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 LCDR2

<400>  431
tttgcttctg agtctatctc t                                                 21


<210>  432
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb 48 LCDR3

<400>  432
caacaaagta atagctggcc gctcacg                                           27


<210>  433
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT-mHingeG1_rev

<400>  433
gcaaggctta caaccacaat c                                                 21


<210>  434
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT-mHingeG2a_rev

<400>  434
gaggacaggg cttgattgtg g                                                 21


<210>  435
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT-mHingeG2b_rev

<400>  435
gaggacaggg gttgattgtt g                                                 21


<210>  436
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT-mHingeG2c_rev

<400>  436
ggacaggggt tctgtgttat gg                                                22


<210>  437
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT-mHingeG3_rev

<400>  437
ctgggcttgg gtattctagg                                                   20


<210>  438
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT_mKappaCL_rev

<400>  438
ctcattcctg ttgaagctct tg                                                22


<210>  439
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT_mLambda1/4-CL_rev

<400>  439
gcacgggaca aactcttctc                                                   20


<210>  440
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RT_mLambda2/3-CL_rev

<400>  440
ctgcaggaga cagactcttc tc                                                22


<210>  441
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE-5E_mG1_rev

<400>  441
gttagtttgg gcagcagatc                                                   20


<210>  442
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE-5E_mG2a.2c_rev

<400>  442
gaggagccag ttgtayctc                                                    19


<210>  443
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE-5E_mG2b_rev

<400>  443
gaaccagttg tatctccaca c                                                 21


<210>  444
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE_5E_G3_rev

<400>  444
gatccagatg tgtcactgc                                                    19


<210>  445
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE-5E_mKappaCL_rev

<400>  445
gtgggaagat ggatacagtt g                                                 21


<210>  446
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE-5E_mLambda1/4_rev

<400>  446
gagctcttca gaggaaggtg                                                   20


<210>  447
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE-5E_mLambda2/3_rev

<400>  447
ctcagrggaa ggtggaaac                                                    19


<210>  448
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo RACE-5E_mLambda2/3_rev3

<400>  448
gagctcctca grggaaggtg                                                   20


<210>  449
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo XSCTnTag

<400>  449
gactcgagtc gacatcgatt tttttttttt ttttt                                  35


<210>  450
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo M13 Forward

<400>  450
gtaaaacgac ggccag                                                       16


<210>  451
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo M13 Reverse

<400>  451
caggaaacag ctatgac                                                      17


