                         SEQUENCE LISTING

<110>  Ͼѱ¹ҽƼ޹˾
 
<120>  ȫԴİCD19CD22˫쿹ԭǶ弰Ӧ

<130>  P10736-PCT

<150>  CN202010618929.6
<151>  2020-06-30

<150>  CN202010707612.X
<151>  2020-07-21

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-62 VH 

<400>  1
atggccgaag tgcagctggt gcagtctggg gcagaggtga aaaagcccgg ggagtctctg       60

aagatctcct gtaaggggtc tggatacagc tttaccaact cctggatcgg atgggtgcgc      120

cagatgcccg ggaaaggcct ggagtggatg ggactcattt accctgatga ctctgatacc      180

agatacagcc catccttcca aggccaggtc accatctcag ccgacagcgc catcaacacc      240

gcctacctgc agtggagcag cctgaaggcc tcggacaccg ccatgtatta ctgtgcgcgc      300

cagtctacct acatctacgg tggttactac gatacctggg gtcaaggtac tctggtgacc      360

gtctcctca                                                              369


<210>  2
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-62 VH 

<400>  2

Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro 
    50                  55                  60                  


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Ser Ala Ile Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly Gly Tyr Tyr Asp Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-62 VL

<400>  3
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatgagaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttgg      300

agggtgttcg gcggagggac caagctgacc gtcctaggt                             339


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-62 VL

<400>  4

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  5
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-78 VL

<400>  5
caggctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taagctggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctcccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg      300

ttcggcggag ggaccaaggt caccgtccta ggt                                   333


<210>  6
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-78 VL

<400>  6

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  7
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-78 VH

<400>  7
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gcgcctgtct      300

tactcttggt cttcttggta ctgggatttc tggggtcaag gtactctggt gaccgtctcc      360

tca                                                                    363


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-78 VH

<400>  8

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD22-80 VH 

<400>  9
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtagtaact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccaactac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggcggtgt actactgcgc cagacttcct      300

ggatacgagt cagctttcga catatggggt cagggtacaa tggtcaccgt cagctca         357


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22-80 VH 

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD22-80 VL

<400>  11
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag caggccggac tcttccctta cacttttggc      300

ggagggacca aggttgagat caaa                                             324


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22-80 VL

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD22-28 VH 

<400>  13
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

gccgggaagg gactggagtg gattgggcgt atctatacca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gcggtgtact actgcgccag agacttgtac      300

agagatggaa tggacgtatg gggccaggga acaactgtca ccgtcagctc a               351


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22-28 VH 

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Tyr Arg Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD22-28 VL

<400>  15
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctccgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccagcag gccaatacct actctcctac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22-28 VL

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Tyr Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker1 

<400>  17
ggtggtggtg gtagcggcgg cggcggctct ggtggtggtg gatcc                       45


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker1

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker2

<400>  19
ggcggaggtg ggtcc                                                        15


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker2

<400>  20

Gly Gly Gly Gly Ser 
1               5   


<210>  21
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker3 

<400>  21
ggcggaggtg ggtccggtgg cgggggaagc ggaggcggag ggagcggagg agggggatct       60

ggaggcggtg ggtct                                                        75


<210>  22
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker3

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  23
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker4

<400>  23
ggcagcacca gcggctccgg caagcctggc tctggcgagg gcagcacaaa ggga             54


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker4

<400>  24

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  25
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8a hinge

<400>  25
actactaccc ctgcacctag gcctcccacc ccagccccaa caatcgccag ccagcctctg       60

tctctgcggc ccgaagcctg tagacctgct gccggcggag ccgtgcacac cagaggcctg      120

gacttcgcct gcgac                                                       135


<210>  26
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a hinge

<400>  26

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  27
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8a TM

<400>  27
atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgag cctggtgatc       60

accctgtact gc                                                           72


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a TM

<400>  28

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  29
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BBڽṹ(IC)

<400>  29
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  30
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB ڽṹ(IC)

<400>  30

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  31
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zźŽṹ

<400>  31
agagtgaagt tcagcagatc cgccgacgcc cctgcctacc agcagggaca gaaccagctg       60

tacaacgagc tgaacctggg cagacgggaa gagtacgacg tgctggacaa gcggagaggc      120

cgggaccccg agatgggcgg aaagcccaga cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcgcggca agggccacga tggcctgtac cagggcctga gcaccgccac caaggacacc      300

tacgacgccc tgcacatgca ggccctgccc cccaga                                336


<210>  32
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zźŽṹ

<400>  32

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  33
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  33
gagggaaggg gcagcttatt aacatgtggc gatgtggaag agaaccccgg tccc             54


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  34

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  35
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CSF2RA signal

<400>  35
atgctgctgc tcgtgacctc tttactgtta tgtgagctgc cccaccccgc ttttttactg       60

atccct                                                                  66


<210>  36
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2RA signal

<400>  36

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  37
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tEGFR

<400>  37
cgtaaggtgt gtaacggaat cggcattggc gagttcaagg actctttaag catcaacgcc       60

acaaacatca agcacttcaa gaattgtacc tccatcagcg gcgatttaca cattctcccc      120

gtggcttttc gtggcgattc cttcacccac accccccctc tggaccccca agagctggac      180

attttaaaaa ccgtgaagga gatcaccggc tttctgctga tccaagcttg gcccgagaat      240

cgtaccgacc tccacgcctt cgagaattta gagattattc gtggaaggac caagcagcac      300

ggccagttct ctttagccgt cgtgtcttta aacattacca gcctcggttt aaggtcttta      360

aaggagatta gcgacggcga cgtgatcatc tccggcaaca agaacctctg ctacgccaac      420

accatcaact ggaagaagct gttcggaacc agcggccaaa agaccaagat catcagcaat      480

cgtggagaga actcttgtaa ggccactggt caagtttgcc acgccctctg tagccccgaa      540

ggatgttggg gccccgagcc tagggactgt gttagctgca gaaacgtgag cagaggcaga      600

gagtgtgtgg acaaatgcaa tttactggaa ggagagccta gggagttcgt ggagaacagc      660

gaatgtatcc agtgccaccc cgagtgttta cctcaagcca tgaacatcac ttgtaccgga      720

aggggccccg ataactgcat ccaatgcgcc cactacatcg acggacccca ctgcgtgaaa      780

acttgtcccg ccggagtgat gggagagaat aacactttag tgtggaagta cgccgacgct      840

ggccacgtct gccatctgtg ccaccccaac tgtacctacg gctgcactgg tcccggttta      900

gagggatgtc ctaccaacgg ccccaagatc ccctccatcg ccaccggaat ggtgggcgct      960

ctgttattac tgctggtggt ggctctgggc atcggtttat tcatg                     1005


<210>  38
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tEGFR

<400>  38

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  39
<211>  2328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1# car

<400>  39
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccagtctg tcgtgacgca gccgccctca gtgtctgggg ccccagggca gagggtcacc      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt atgatgtaca ctggtaccag      180

caacttccag gaacagcccc caaactcctc atctatgaga acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag cctccctggc catcactggg      300

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgagtggt      360

tggagggtgt tcggcggagg gaccaagctg accgtcctag gtggtggtgg tggtagcggc      420

ggcggcggct ctggtggtgg tggatccatg gccgaagtgc agctggtgca gtctggggca      480

gaggtgaaaa agcccgggga gtctctgaag atctcctgta aggggtctgg atacagcttt      540

accaactcct ggatcggatg ggtgcgccag atgcccggga aaggcctgga gtggatggga      600

ctcatttacc ctgatgactc tgataccaga tacagcccat ccttccaagg ccaggtcacc      660

atctcagccg acagcgccat caacaccgcc tacctgcagt ggagcagcct gaaggcctcg      720

gacaccgcca tgtattactg tgcgcgccag tctacctaca tctacggtgg ttactacgat      780

acctggggtc aaggtactct ggtgaccgtc tcctcaggcg gaggtgggtc cggtggcggg      840

ggaagcggag gcggagggag cggaggaggg ggatctggag gcggtgggtc tcaggtgcag      900

ctgcaggagt cgggcccagg actggtgaag ccttcgggga ccctgtccct cacctgcgct      960

gtctctggtg gctccatcag cagtagtaac tggtggagtt gggtccgcca gcccccaggg     1020

aaggggctgg agtggattgg ggaaatctat catagtggga gcaccaacta caacccgtcc     1080

ctcaagagtc gagtcaccat atcagtagac aagtccaaga accagttctc cctgaagctg     1140

agctctgtga ccgccgcgga cacggcggtg tactactgcg ccagacttcc tggatacgag     1200

tcagctttcg acatatgggg tcagggtaca atggtcaccg tcagctcagg tggcgggggc     1260

agcggcggag gcggatccgg aggcggaggg agtgaaattg tgttgacgca gtctccaggc     1320

accctgtctt tgtctccagg ggaaagagcc accctctcct gcagggccag tcagagtgtt     1380

agcagcagct acttagcctg gtaccagcag aaacctggcc aggctcccag gctcctcatc     1440

tatggtgcat ccagcagggc cactggcatc ccagacaggt tcagtggcag tgggtctggg     1500

acagacttca ctctcaccat cagcagactg gagcctgaag attttgcagt gtattactgt     1560

cagcaggccg gactcttccc ttacactttt ggcggaggga ccaaggttga gatcaaattc     1620

gtgcccgtgt tcctgcccgc caaacctact actacccctg cacctaggcc tcccacccca     1680

gccccaacaa tcgccagcca gcctctgtct ctgcggcccg aagcctgtag acctgctgcc     1740

ggcggagccg tgcacaccag aggcctggac ttcgcctgcg acatctacat ctgggcccct     1800

ctggccggca cctgtggcgt gctgctgctg agcctggtga tcaccctgta ctgcaaccac     1860

cggaacaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1920

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1980

ggatgtgaac tgagagtgaa gttcagcaga tccgccgacg cccctgccta ccagcaggga     2040

cagaaccagc tgtacaacga gctgaacctg ggcagacggg aagagtacga cgtgctggac     2100

aagcggagag gccgggaccc cgagatgggc ggaaagccca gacggaagaa cccccaggaa     2160

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     2220

aagggcgagc ggaggcgcgg caagggccac gatggcctgt accagggcct gagcaccgcc     2280

accaaggaca cctacgacgc cctgcacatg caggccctgc cccccaga                  2328


<210>  40
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1# CAR

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala 
145                 150                 155                 160 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                165                 170                 175     


Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp 
        195                 200                 205             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    210                 215                 220                 


Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly 
                245                 250                 255     


Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
    290                 295                 300                 


Gly Pro Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala 
305                 310                 315                 320 


Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg 
                325                 330                 335     


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser 
            340                 345                 350         


Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
        355                 360                 365             


Val Asp Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
    370                 375                 380                 


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu 
385                 390                 395                 400 


Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
            420                 425                 430         


Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
        435                 440                 445             


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr 
    450                 455                 460                 


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
465                 470                 475                 480 


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
            500                 505                 510         


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro Tyr 
        515                 520                 525             


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Phe Val Pro Val Phe 
    530                 535                 540                 


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
545                 550                 555                 560 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                565                 570                 575     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            580                 585                 590         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        595                 600                 605             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg 
    610                 615                 620                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
625                 630                 635                 640 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                645                 650                 655     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            660                 665                 670         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        675                 680                 685             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    690                 695                 700                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
705                 710                 715                 720 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                725                 730                 735     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            740                 745                 750         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        755                 760                 765             


His Met Gln Ala Leu Pro Pro Arg 
    770                 775     


<210>  41
<211>  2328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2# CAR

<400>  41
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccaggtgc agctgcagga gtcgggccca ggactggtga agccttcggg gaccctgtcc      120

ctcacctgcg ctgtctctgg tggctccatc agcagtagta actggtggag ttgggtccgc      180

cagcccccag ggaaggggct ggagtggatt ggggaaatct atcatagtgg gagcaccaac      240

tacaacccgt ccctcaagag tcgagtcacc atatcagtag acaagtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgccgcg gacacggcgg tgtactactg cgccagactt      360

cctggatacg agtcagcttt cgacatatgg ggtcagggta caatggtcac cgtcagctca      420

ggtggcgggg gcagcggcgg aggcggatcc ggaggcggag ggagtgaaat tgtgttgacg      480

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc      540

agtcagagtg ttagcagcag ctacttagcc tggtaccagc agaaacctgg ccaggctccc      600

aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag gttcagtggc      660

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca      720

gtgtattact gtcagcaggc cggactcttc ccttacactt ttggcggagg gaccaaggtt      780

gagatcaaag gcggaggtgg gtccggtggc gggggaagcg gaggcggagg gagcggagga      840

gggggatctg gaggcggtgg gtctcagtct gtcgtgacgc agccgccctc agtgtctggg      900

gccccagggc agagggtcac catctcctgc actgggagca gctccaacat cggggcaggt      960

tatgatgtac actggtacca gcaacttcca ggaacagccc ccaaactcct catctatgag     1020

aacaccaatc ggccctcagg ggtccctgac cgattctctg gctccaagtc tggcacctca     1080

gcctccctgg ccatcactgg gctccaggct gaggatgagg ctgattatta ctgccagtcc     1140

tatgacagca gcctgagtgg ttggagggtg ttcggcggag ggaccaagct gaccgtccta     1200

ggtggtggtg gtggtagcgg cggcggcggc tctggtggtg gtggatccat ggccgaagtg     1260

cagctggtgc agtctggggc agaggtgaaa aagcccgggg agtctctgaa gatctcctgt     1320

aaggggtctg gatacagctt taccaactcc tggatcggat gggtgcgcca gatgcccggg     1380

aaaggcctgg agtggatggg actcatttac cctgatgact ctgataccag atacagccca     1440

tccttccaag gccaggtcac catctcagcc gacagcgcca tcaacaccgc ctacctgcag     1500

tggagcagcc tgaaggcctc ggacaccgcc atgtattact gtgcgcgcca gtctacctac     1560

atctacggtg gttactacga tacctggggt caaggtactc tggtgaccgt ctcctcattc     1620

gtgcccgtgt tcctgcccgc caaacctact actacccctg cacctaggcc tcccacccca     1680

gccccaacaa tcgccagcca gcctctgtct ctgcggcccg aagcctgtag acctgctgcc     1740

ggcggagccg tgcacaccag aggcctggac ttcgcctgcg acatctacat ctgggcccct     1800

ctggccggca cctgtggcgt gctgctgctg agcctggtga tcaccctgta ctgcaaccac     1860

cggaacaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1920

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1980

ggatgtgaac tgagagtgaa gttcagcaga tccgccgacg cccctgccta ccagcaggga     2040

cagaaccagc tgtacaacga gctgaacctg ggcagacggg aagagtacga cgtgctggac     2100

aagcggagag gccgggaccc cgagatgggc ggaaagccca gacggaagaa cccccaggaa     2160

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     2220

aagggcgagc ggaggcgcgg caagggccac gatggcctgt accagggcct gagcaccgcc     2280

accaaggaca cctacgacgc cctgcacatg caggccctgc cccccaga                  2328


<210>  42
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2# CAR

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
    290                 295                 300                 


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
305                 310                 315                 320 


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
                325                 330                 335     


Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
            340                 345                 350         


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
        355                 360                 365             


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
    370                 375                 380                 


Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
385                 390                 395                 400 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            420                 425                 430         


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
        435                 440                 445             


Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
    450                 455                 460                 


Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro 
465                 470                 475                 480 


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Ser Ala Ile Asn Thr 
                485                 490                 495     


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
            500                 505                 510         


Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly Gly Tyr Tyr Asp Thr 
        515                 520                 525             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe 
    530                 535                 540                 


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
545                 550                 555                 560 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                565                 570                 575     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            580                 585                 590         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        595                 600                 605             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg 
    610                 615                 620                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
625                 630                 635                 640 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                645                 650                 655     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            660                 665                 670         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        675                 680                 685             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    690                 695                 700                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
705                 710                 715                 720 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                725                 730                 735     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            740                 745                 750         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        755                 760                 765             


His Met Gln Ala Leu Pro Pro Arg 
    770                 775     


<210>  43
<211>  2298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3# CAR

<400>  43
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccagtctg tcgtgacgca gccgccctca gtgtctgggg ccccagggca gagggtcacc      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt atgatgtaca ctggtaccag      180

caacttccag gaacagcccc caaactcctc atctatgaga acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag cctccctggc catcactggg      300

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgagtggt      360

tggagggtgt tcggcggagg gaccaagctg accgtcctag gtggtggtgg tggtagcggc      420

ggcggcggct ctggtggtgg tggatccatg gccgaagtgc agctggtgca gtctggggca      480

gaggtgaaaa agcccgggga gtctctgaag atctcctgta aggggtctgg atacagcttt      540

accaactcct ggatcggatg ggtgcgccag atgcccggga aaggcctgga gtggatggga      600

ctcatttacc ctgatgactc tgataccaga tacagcccat ccttccaagg ccaggtcacc      660

atctcagccg acagcgccat caacaccgcc tacctgcagt ggagcagcct gaaggcctcg      720

gacaccgcca tgtattactg tgcgcgccag tctacctaca tctacggtgg ttactacgat      780

acctggggtc aaggtactct ggtgaccgtc tcctcaggcg gaggtgggtc cggtggcggg      840

ggaagcggag gcggagggag ccaggtgcag ctgcaggagt cgggcccagg actggtgaag      900

ccttcgggga ccctgtccct cacctgcgct gtctctggtg gctccatcag cagtagtaac      960

tggtggagtt gggtccgcca gcccccaggg aaggggctgg agtggattgg ggaaatctat     1020

catagtggga gcaccaacta caacccgtcc ctcaagagtc gagtcaccat atcagtagac     1080

aagtccaaga accagttctc cctgaagctg agctctgtga ccgccgcgga cacggcggtg     1140

tactactgcg ccagacttcc tggatacgag tcagctttcg acatatgggg tcagggtaca     1200

atggtcaccg tcagctcagg tggcgggggc agcggcggag gcggatccgg aggcggaggg     1260

agtgaaattg tgttgacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc     1320

accctctcct gcagggccag tcagagtgtt agcagcagct acttagcctg gtaccagcag     1380

aaacctggcc aggctcccag gctcctcatc tatggtgcat ccagcagggc cactggcatc     1440

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg     1500

gagcctgaag attttgcagt gtattactgt cagcaggccg gactcttccc ttacactttt     1560

ggcggaggga ccaaggttga gatcaaattc gtgcccgtgt tcctgcccgc caaacctact     1620

actacccctg cacctaggcc tcccacccca gccccaacaa tcgccagcca gcctctgtct     1680

ctgcggcccg aagcctgtag acctgctgcc ggcggagccg tgcacaccag aggcctggac     1740

ttcgcctgcg acatctacat ctgggcccct ctggccggca cctgtggcgt gctgctgctg     1800

agcctggtga tcaccctgta ctgcaaccac cggaacaaac ggggcagaaa gaaactcctg     1860

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1920

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcaga     1980

tccgccgacg cccctgccta ccagcaggga cagaaccagc tgtacaacga gctgaacctg     2040

ggcagacggg aagagtacga cgtgctggac aagcggagag gccgggaccc cgagatgggc     2100

ggaaagccca gacggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2160

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgcgg caagggccac     2220

gatggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     2280

caggccctgc cccccaga                                                   2298


<210>  44
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3# CAR

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala 
145                 150                 155                 160 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                165                 170                 175     


Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp 
        195                 200                 205             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    210                 215                 220                 


Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly 
                245                 250                 255     


Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        275                 280                 285             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly Thr 
    290                 295                 300                 


Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser Asn 
305                 310                 315                 320 


Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                325                 330                 335     


Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
            340                 345                 350         


Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser Leu 
        355                 360                 365             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    370                 375                 380                 


Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr 
385                 390                 395                 400 


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        435                 440                 445             


Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    450                 455                 460                 


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
465                 470                 475                 480 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                485                 490                 495     


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            500                 505                 510         


Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        515                 520                 525             


Lys Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala 
    530                 535                 540                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
545                 550                 555                 560 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                565                 570                 575     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            580                 585                 590         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        595                 600                 605             


Asn His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    610                 615                 620                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
625                 630                 635                 640 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                645                 650                 655     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            660                 665                 670         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        675                 680                 685             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    690                 695                 700                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
705                 710                 715                 720 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                725                 730                 735     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            740                 745                 750         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 765     


<210>  45
<211>  2298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4# CAR

<400>  45
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccaggtgc agctgcagga gtcgggccca ggactggtga agccttcggg gaccctgtcc      120

ctcacctgcg ctgtctctgg tggctccatc agcagtagta actggtggag ttgggtccgc      180

cagcccccag ggaaggggct ggagtggatt ggggaaatct atcatagtgg gagcaccaac      240

tacaacccgt ccctcaagag tcgagtcacc atatcagtag acaagtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgccgcg gacacggcgg tgtactactg cgccagactt      360

cctggatacg agtcagcttt cgacatatgg ggtcagggta caatggtcac cgtcagctca      420

ggtggcgggg gcagcggcgg aggcggatcc ggaggcggag ggagtgaaat tgtgttgacg      480

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc      540

agtcagagtg ttagcagcag ctacttagcc tggtaccagc agaaacctgg ccaggctccc      600

aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag gttcagtggc      660

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca      720

gtgtattact gtcagcaggc cggactcttc ccttacactt ttggcggagg gaccaaggtt      780

gagatcaaag gcggaggtgg gtccggtggc gggggaagcg gaggcggagg gagccagtct      840

gtcgtgacgc agccgccctc agtgtctggg gccccagggc agagggtcac catctcctgc      900

actgggagca gctccaacat cggggcaggt tatgatgtac actggtacca gcaacttcca      960

ggaacagccc ccaaactcct catctatgag aacaccaatc ggccctcagg ggtccctgac     1020

cgattctctg gctccaagtc tggcacctca gcctccctgg ccatcactgg gctccaggct     1080

gaggatgagg ctgattatta ctgccagtcc tatgacagca gcctgagtgg ttggagggtg     1140

ttcggcggag ggaccaagct gaccgtccta ggtggtggtg gtggtagcgg cggcggcggc     1200

tctggtggtg gtggatccat ggccgaagtg cagctggtgc agtctggggc agaggtgaaa     1260

aagcccgggg agtctctgaa gatctcctgt aaggggtctg gatacagctt taccaactcc     1320

tggatcggat gggtgcgcca gatgcccggg aaaggcctgg agtggatggg actcatttac     1380

cctgatgact ctgataccag atacagccca tccttccaag gccaggtcac catctcagcc     1440

gacagcgcca tcaacaccgc ctacctgcag tggagcagcc tgaaggcctc ggacaccgcc     1500

atgtattact gtgcgcgcca gtctacctac atctacggtg gttactacga tacctggggt     1560

caaggtactc tggtgaccgt ctcctcattc gtgcccgtgt tcctgcccgc caaacctact     1620

actacccctg cacctaggcc tcccacccca gccccaacaa tcgccagcca gcctctgtct     1680

ctgcggcccg aagcctgtag acctgctgcc ggcggagccg tgcacaccag aggcctggac     1740

ttcgcctgcg acatctacat ctgggcccct ctggccggca cctgtggcgt gctgctgctg     1800

agcctggtga tcaccctgta ctgcaaccac cggaacaaac ggggcagaaa gaaactcctg     1860

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1920

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcaga     1980

tccgccgacg cccctgccta ccagcaggga cagaaccagc tgtacaacga gctgaacctg     2040

ggcagacggg aagagtacga cgtgctggac aagcggagag gccgggaccc cgagatgggc     2100

ggaaagccca gacggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2160

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgcgg caagggccac     2220

gatggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     2280

caggccctgc cccccaga                                                   2298


<210>  46
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4# CAR

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ser Val Val Thr Gln Pro Pro Ser Val 
        275                 280                 285             


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
    290                 295                 300                 


Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro 
305                 310                 315                 320 


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser 
                325                 330                 335     


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
            340                 345                 350         


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
        355                 360                 365             


Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly 
    370                 375                 380                 


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly 
                405                 410                 415     


Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly 
            420                 425                 430         


Ser Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met 
        435                 440                 445             


Pro Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser 
    450                 455                 460                 


Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala 
465                 470                 475                 480 


Asp Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala 
                485                 490                 495     


Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr 
            500                 505                 510         


Gly Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        515                 520                 525             


Ser Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala 
    530                 535                 540                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
545                 550                 555                 560 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                565                 570                 575     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            580                 585                 590         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        595                 600                 605             


Asn His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    610                 615                 620                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
625                 630                 635                 640 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                645                 650                 655     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            660                 665                 670         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        675                 680                 685             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    690                 695                 700                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
705                 710                 715                 720 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                725                 730                 735     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            740                 745                 750         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 765     


<210>  47
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5# CAR

<400>  47
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccagtctg tcgtgacgca gccgccctca gtgtctgggg ccccagggca gagggtcacc      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt atgatgtaca ctggtaccag      180

caacttccag gaacagcccc caaactcctc atctatgaga acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag cctccctggc catcactggg      300

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgagtggt      360

tggagggtgt tcggcggagg gaccaagctg accgtcctag gtggtggtgg tggtagcggc      420

ggcggcggct ctggtggtgg tggatccatg gccgaagtgc agctggtgca gtctggggca      480

gaggtgaaaa agcccgggga gtctctgaag atctcctgta aggggtctgg atacagcttt      540

accaactcct ggatcggatg ggtgcgccag atgcccggga aaggcctgga gtggatggga      600

ctcatttacc ctgatgactc tgataccaga tacagcccat ccttccaagg ccaggtcacc      660

atctcagccg acagcgccat caacaccgcc tacctgcagt ggagcagcct gaaggcctcg      720

gacaccgcca tgtattactg tgcgcgccag tctacctaca tctacggtgg ttactacgat      780

acctggggtc aaggtactct ggtgaccgtc tcctcaggcg gaggtgggtc ccaggtgcag      840

ctgcaggagt cgggcccagg actggtgaag ccttcgggga ccctgtccct cacctgcgct      900

gtctctggtg gctccatcag cagtagtaac tggtggagtt gggtccgcca gcccccaggg      960

aaggggctgg agtggattgg ggaaatctat catagtggga gcaccaacta caacccgtcc     1020

ctcaagagtc gagtcaccat atcagtagac aagtccaaga accagttctc cctgaagctg     1080

agctctgtga ccgccgcgga cacggcggtg tactactgcg ccagacttcc tggatacgag     1140

tcagctttcg acatatgggg tcagggtaca atggtcaccg tcagctcagg tggcgggggc     1200

agcggcggag gcggatccgg aggcggaggg agtgaaattg tgttgacgca gtctccaggc     1260

accctgtctt tgtctccagg ggaaagagcc accctctcct gcagggccag tcagagtgtt     1320

agcagcagct acttagcctg gtaccagcag aaacctggcc aggctcccag gctcctcatc     1380

tatggtgcat ccagcagggc cactggcatc ccagacaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagactg gagcctgaag attttgcagt gtattactgt     1500

cagcaggccg gactcttccc ttacactttt ggcggaggga ccaaggttga gatcaaattc     1560

gtgcccgtgt tcctgcccgc caaacctact actacccctg cacctaggcc tcccacccca     1620

gccccaacaa tcgccagcca gcctctgtct ctgcggcccg aagcctgtag acctgctgcc     1680

ggcggagccg tgcacaccag aggcctggac ttcgcctgcg acatctacat ctgggcccct     1740

ctggccggca cctgtggcgt gctgctgctg agcctggtga tcaccctgta ctgcaaccac     1800

cggaacaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1860

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1920

ggatgtgaac tgagagtgaa gttcagcaga tccgccgacg cccctgccta ccagcaggga     1980

cagaaccagc tgtacaacga gctgaacctg ggcagacggg aagagtacga cgtgctggac     2040

aagcggagag gccgggaccc cgagatgggc ggaaagccca gacggaagaa cccccaggaa     2100

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     2160

aagggcgagc ggaggcgcgg caagggccac gatggcctgt accagggcct gagcaccgcc     2220

accaaggaca cctacgacgc cctgcacatg caggccctgc cccccaga                  2268


<210>  48
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5# CAR

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala 
145                 150                 155                 160 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                165                 170                 175     


Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp 
        195                 200                 205             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    210                 215                 220                 


Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly 
                245                 250                 255     


Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
        275                 280                 285             


Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly 
    290                 295                 300                 


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn 
                325                 330                 335     


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
            340                 345                 350         


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp 
    370                 375                 380                 


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
                405                 410                 415     


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
            420                 425                 430         


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
    450                 455                 460                 


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
                485                 490                 495     


Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Val Glu Ile Lys Phe Val Pro Val Phe Leu Pro Ala Lys 
        515                 520                 525             


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    530                 535                 540                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
545                 550                 555                 560 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                565                 570                 575     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            580                 585                 590         


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys 
        595                 600                 605             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    610                 615                 620                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
625                 630                 635                 640 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                645                 650                 655     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            660                 665                 670         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        675                 680                 685             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    690                 695                 700                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
705                 710                 715                 720 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                725                 730                 735     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            740                 745                 750         


Leu Pro Pro Arg 
        755     


<210>  49
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6# CAR

<400>  49
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccaggtgc agctgcagga gtcgggccca ggactggtga agccttcggg gaccctgtcc      120

ctcacctgcg ctgtctctgg tggctccatc agcagtagta actggtggag ttgggtccgc      180

cagcccccag ggaaggggct ggagtggatt ggggaaatct atcatagtgg gagcaccaac      240

tacaacccgt ccctcaagag tcgagtcacc atatcagtag acaagtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgccgcg gacacggcgg tgtactactg cgccagactt      360

cctggatacg agtcagcttt cgacatatgg ggtcagggta caatggtcac cgtcagctca      420

ggtggcgggg gcagcggcgg aggcggatcc ggaggcggag ggagtgaaat tgtgttgacg      480

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc      540

agtcagagtg ttagcagcag ctacttagcc tggtaccagc agaaacctgg ccaggctccc      600

aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag gttcagtggc      660

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca      720

gtgtattact gtcagcaggc cggactcttc ccttacactt ttggcggagg gaccaaggtt      780

gagatcaaag gcggaggtgg gtcccagtct gtcgtgacgc agccgccctc agtgtctggg      840

gccccagggc agagggtcac catctcctgc actgggagca gctccaacat cggggcaggt      900

tatgatgtac actggtacca gcaacttcca ggaacagccc ccaaactcct catctatgag      960

aacaccaatc ggccctcagg ggtccctgac cgattctctg gctccaagtc tggcacctca     1020

gcctccctgg ccatcactgg gctccaggct gaggatgagg ctgattatta ctgccagtcc     1080

tatgacagca gcctgagtgg ttggagggtg ttcggcggag ggaccaagct gaccgtccta     1140

ggtggtggtg gtggtagcgg cggcggcggc tctggtggtg gtggatccat ggccgaagtg     1200

cagctggtgc agtctggggc agaggtgaaa aagcccgggg agtctctgaa gatctcctgt     1260

aaggggtctg gatacagctt taccaactcc tggatcggat gggtgcgcca gatgcccggg     1320

aaaggcctgg agtggatggg actcatttac cctgatgact ctgataccag atacagccca     1380

tccttccaag gccaggtcac catctcagcc gacagcgcca tcaacaccgc ctacctgcag     1440

tggagcagcc tgaaggcctc ggacaccgcc atgtattact gtgcgcgcca gtctacctac     1500

atctacggtg gttactacga tacctggggt caaggtactc tggtgaccgt ctcctcattc     1560

gtgcccgtgt tcctgcccgc caaacctact actacccctg cacctaggcc tcccacccca     1620

gccccaacaa tcgccagcca gcctctgtct ctgcggcccg aagcctgtag acctgctgcc     1680

ggcggagccg tgcacaccag aggcctggac ttcgcctgcg acatctacat ctgggcccct     1740

ctggccggca cctgtggcgt gctgctgctg agcctggtga tcaccctgta ctgcaaccac     1800

cggaacaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1860

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1920

ggatgtgaac tgagagtgaa gttcagcaga tccgccgacg cccctgccta ccagcaggga     1980

cagaaccagc tgtacaacga gctgaacctg ggcagacggg aagagtacga cgtgctggac     2040

aagcggagag gccgggaccc cgagatgggc ggaaagccca gacggaagaa cccccaggaa     2100

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     2160

aagggcgagc ggaggcgcgg caagggccac gatggcctgt accagggcct gagcaccgcc     2220

accaaggaca cctacgacgc cctgcacatg caggccctgc cccccaga                  2268


<210>  50
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6# CAR

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Ser Val Val 
            260                 265                 270         


Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile 
        275                 280                 285             


Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
    290                 295                 300                 


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu 
305                 310                 315                 320 


Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
                325                 330                 335     


Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp 
            340                 345                 350         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp 
        355                 360                 365             


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala Glu Val 
385                 390                 395                 400 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu 
                405                 410                 415     


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Ser Trp Ile 
            420                 425                 430         


Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Leu 
        435                 440                 445             


Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly 
    450                 455                 460                 


Gln Val Thr Ile Ser Ala Asp Ser Ala Ile Asn Thr Ala Tyr Leu Gln 
465                 470                 475                 480 


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
                485                 490                 495     


Gln Ser Thr Tyr Ile Tyr Gly Gly Tyr Tyr Asp Thr Trp Gly Gln Gly 
            500                 505                 510         


Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro Ala Lys 
        515                 520                 525             


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    530                 535                 540                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
545                 550                 555                 560 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                565                 570                 575     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            580                 585                 590         


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys 
        595                 600                 605             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    610                 615                 620                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
625                 630                 635                 640 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                645                 650                 655     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            660                 665                 670         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        675                 680                 685             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    690                 695                 700                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
705                 710                 715                 720 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                725                 730                 735     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            740                 745                 750         


Leu Pro Pro Arg 
        755     


<210>  51
<211>  2259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7# CAR

<400>  51
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccagtctg tcgtgacgca gccgccctca gtgtctgggg ccccagggca gagggtcacc      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt atgatgtaca ctggtaccag      180

caacttccag gaacagcccc caaactcctc atctatgaga acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag cctccctggc catcactggg      300

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgagtggt      360

tggagggtgt tcggcggagg gaccaagctg accgtcctag gtggtggtgg tggtagcggc      420

ggcggcggct ctggtggtgg tggatccatg gccgaagtgc agctggtgca gtctggggca      480

gaggtgaaaa agcccgggga gtctctgaag atctcctgta aggggtctgg atacagcttt      540

accaactcct ggatcggatg ggtgcgccag atgcccggga aaggcctgga gtggatggga      600

ctcatttacc ctgatgactc tgataccaga tacagcccat ccttccaagg ccaggtcacc      660

atctcagccg acagcgccat caacaccgcc tacctgcagt ggagcagcct gaaggcctcg      720

gacaccgcca tgtattactg tgcgcgccag tctacctaca tctacggtgg ttactacgat      780

acctggggtc aaggtactct ggtgaccgtc tcctcaggcg gaggtgggtc ccaggtgcag      840

ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcact      900

gtctctggtg gctccatcag tagttactac tggagctgga tccggcagcc cgccgggaag      960

ggactggagt ggattgggcg tatctatacc agtgggagca ccaactacaa cccctccctc     1020

aagagtcgag tcaccatgtc agtagacacg tccaagaacc agttctccct gaagctgagc     1080

tctgtgaccg ccgcggacac ggcggtgtac tactgcgcca gagacttgta cagagatgga     1140

atggacgtat ggggccaggg aacaactgtc accgtcagct caggtggcgg gggcagcggc     1200

ggaggcggat ccggaggcgg agggagtgac atccagatga cccagtctcc ttccaccctg     1260

tctgcatctg taggagacag agtcaccatc acttgccggg ccagtcagag tattagtagc     1320

tggttggcct ggtatcagca gaaaccaggg aaagccccta agctcctgat ctccgatgcc     1380

tccagtttgg aaagtggggt cccatcaagg ttcagcggca gtggatctgg gacagaattc     1440

actctcacca tcagcagcct gcagcctgat gattttgcaa cttattactg ccagcaggcc     1500

aatacctact ctcctacttt tggcggaggg accaaggttg agatcaaatt cgtgcccgtg     1560

ttcctgcccg ccaaacctac tactacccct gcacctaggc ctcccacccc agccccaaca     1620

atcgccagcc agcctctgtc tctgcggccc gaagcctgta gacctgctgc cggcggagcc     1680

gtgcacacca gaggcctgga cttcgcctgc gacatctaca tctgggcccc tctggccggc     1740

acctgtggcg tgctgctgct gagcctggtg atcaccctgt actgcaacca ccggaacaaa     1800

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1860

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1920

ctgagagtga agttcagcag atccgccgac gcccctgcct accagcaggg acagaaccag     1980

ctgtacaacg agctgaacct gggcagacgg gaagagtacg acgtgctgga caagcggaga     2040

ggccgggacc ccgagatggg cggaaagccc agacggaaga acccccagga aggcctgtat     2100

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggcat gaagggcgag     2160

cggaggcgcg gcaagggcca cgatggcctg taccagggcc tgagcaccgc caccaaggac     2220

acctacgacg ccctgcacat gcaggccctg ccccccaga                            2259


<210>  52
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7# CAR

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala 
145                 150                 155                 160 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                165                 170                 175     


Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp 
        195                 200                 205             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    210                 215                 220                 


Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly 
                245                 250                 255     


Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
        275                 280                 285             


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
    290                 295                 300                 


Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr 
                325                 330                 335     


Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys 
            340                 345                 350         


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
        355                 360                 365             


Val Tyr Tyr Cys Ala Arg Asp Leu Tyr Arg Asp Gly Met Asp Val Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
                405                 410                 415     


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            420                 425                 430         


Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys 
        435                 440                 445             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Asp Ala Ser Ser Leu Glu 
    450                 455                 460                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
465                 470                 475                 480 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Ala Asn Thr Tyr Ser Pro Thr Phe Gly Gly Gly Thr Lys 
            500                 505                 510         


Val Glu Ile Lys Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr 
        515                 520                 525             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    530                 535                 540                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
545                 550                 555                 560 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                565                 570                 575     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            580                 585                 590         


Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        595                 600                 605             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    610                 615                 620                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
625                 630                 635                 640 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                645                 650                 655     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            660                 665                 670         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        675                 680                 685             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    690                 695                 700                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
705                 710                 715                 720 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                725                 730                 735     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            740                 745                 750         


Arg 
    


<210>  53
<211>  2259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8# CAR

<400>  53
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccaggtgc agctgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc      120

ctcacctgca ctgtctctgg tggctccatc agtagttact actggagctg gatccggcag      180

cccgccggga agggactgga gtggattggg cgtatctata ccagtgggag caccaactac      240

aacccctccc tcaagagtcg agtcaccatg tcagtagaca cgtccaagaa ccagttctcc      300

ctgaagctga gctctgtgac cgccgcggac acggcggtgt actactgcgc cagagacttg      360

tacagagatg gaatggacgt atggggccag ggaacaactg tcaccgtcag ctcaggtggc      420

gggggcagcg gcggaggcgg atccggaggc ggagggagtg acatccagat gacccagtct      480

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgccg ggccagtcag      540

agtattagta gctggttggc ctggtatcag cagaaaccag ggaaagcccc taagctcctg      600

atctccgatg cctccagttt ggaaagtggg gtcccatcaa ggttcagcgg cagtggatct      660

gggacagaat tcactctcac catcagcagc ctgcagcctg atgattttgc aacttattac      720

tgccagcagg ccaataccta ctctcctact tttggcggag ggaccaaggt tgagatcaaa      780

ggcggaggtg ggtcccagtc tgtcgtgacg cagccgccct cagtgtctgg ggccccaggg      840

cagagggtca ccatctcctg cactgggagc agctccaaca tcggggcagg ttatgatgta      900

cactggtacc agcaacttcc aggaacagcc cccaaactcc tcatctatga gaacaccaat      960

cggccctcag gggtccctga ccgattctct ggctccaagt ctggcacctc agcctccctg     1020

gccatcactg ggctccaggc tgaggatgag gctgattatt actgccagtc ctatgacagc     1080

agcctgagtg gttggagggt gttcggcgga gggaccaagc tgaccgtcct aggtggtggt     1140

ggtggtagcg gcggcggcgg ctctggtggt ggtggatcca tggccgaagt gcagctggtg     1200

cagtctgggg cagaggtgaa aaagcccggg gagtctctga agatctcctg taaggggtct     1260

ggatacagct ttaccaactc ctggatcgga tgggtgcgcc agatgcccgg gaaaggcctg     1320

gagtggatgg gactcattta ccctgatgac tctgatacca gatacagccc atccttccaa     1380

ggccaggtca ccatctcagc cgacagcgcc atcaacaccg cctacctgca gtggagcagc     1440

ctgaaggcct cggacaccgc catgtattac tgtgcgcgcc agtctaccta catctacggt     1500

ggttactacg atacctgggg tcaaggtact ctggtgaccg tctcctcatt cgtgcccgtg     1560

ttcctgcccg ccaaacctac tactacccct gcacctaggc ctcccacccc agccccaaca     1620

atcgccagcc agcctctgtc tctgcggccc gaagcctgta gacctgctgc cggcggagcc     1680

gtgcacacca gaggcctgga cttcgcctgc gacatctaca tctgggcccc tctggccggc     1740

acctgtggcg tgctgctgct gagcctggtg atcaccctgt actgcaacca ccggaacaaa     1800

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1860

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1920

ctgagagtga agttcagcag atccgccgac gcccctgcct accagcaggg acagaaccag     1980

ctgtacaacg agctgaacct gggcagacgg gaagagtacg acgtgctgga caagcggaga     2040

ggccgggacc ccgagatggg cggaaagccc agacggaaga acccccagga aggcctgtat     2100

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggcat gaagggcgag     2160

cggaggcgcg gcaagggcca cgatggcctg taccagggcc tgagcaccgc caccaaggac     2220

acctacgacg ccctgcacat gcaggccctg ccccccaga                            2259


<210>  54
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8# CAR

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Leu Tyr Arg Asp Gly Met Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Asp Ala Ser Ser Leu Glu 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Ala Asn Thr Tyr Ser Pro Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Ser Val Val Thr Gln Pro 
            260                 265                 270         


Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr 
        275                 280                 285             


Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln 
    290                 295                 300                 


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn 
305                 310                 315                 320 


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
                325                 330                 335     


Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp 
            340                 345                 350         


Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe 
        355                 360                 365             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val 
385                 390                 395                 400 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
                405                 410                 415     


Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val 
            420                 425                 430         


Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro 
        435                 440                 445             


Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr 
    450                 455                 460                 


Ile Ser Ala Asp Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser 
465                 470                 475                 480 


Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr 
                485                 490                 495     


Tyr Ile Tyr Gly Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val 
            500                 505                 510         


Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr 
        515                 520                 525             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    530                 535                 540                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
545                 550                 555                 560 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                565                 570                 575     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            580                 585                 590         


Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        595                 600                 605             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    610                 615                 620                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
625                 630                 635                 640 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                645                 650                 655     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            660                 665                 670         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        675                 680                 685             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    690                 695                 700                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
705                 710                 715                 720 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                725                 730                 735     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            740                 745                 750         


Arg 
    


<210>  55
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9# CAR

<400>  55
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccagtctg tcgtgacgca gccgccctca gtgtctgggg ccccagggca gagggtcacc      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt atgatgtaca ctggtaccag      180

caacttccag gaacagcccc caaactcctc atctatgaga acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag cctccctggc catcactggg      300

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgagtggt      360

tggagggtgt tcggcggagg gaccaagctg accgtcctag gtggtggtgg tggtagccag      420

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cggggaccct gtccctcacc      480

tgcgctgtct ctggtggctc catcagcagt agtaactggt ggagttgggt ccgccagccc      540

ccagggaagg ggctggagtg gattggggaa atctatcata gtgggagcac caactacaac      600

ccgtccctca agagtcgagt caccatatca gtagacaagt ccaagaacca gttctccctg      660

aagctgagct ctgtgaccgc cgcggacacg gcggtgtact actgcgccag acttcctgga      720

tacgagtcag ctttcgacat atggggtcag ggtacaatgg tcaccgtcag ctcaggcagc      780

accagcggct ccggcaagcc tggctctggc gagggcagca caaagggaga aattgtgttg      840

acgcagtctc caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg      900

gccagtcaga gtgttagcag cagctactta gcctggtacc agcagaaacc tggccaggct      960

cccaggctcc tcatctatgg tgcatccagc agggccactg gcatcccaga caggttcagt     1020

ggcagtgggt ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt     1080

gcagtgtatt actgtcagca ggccggactc ttcccttaca cttttggcgg agggaccaag     1140

gttgagatca aaggtggcgg gggcagcatg gccgaagtgc agctggtgca gtctggggca     1200

gaggtgaaaa agcccgggga gtctctgaag atctcctgta aggggtctgg atacagcttt     1260

accaactcct ggatcggatg ggtgcgccag atgcccggga aaggcctgga gtggatggga     1320

ctcatttacc ctgatgactc tgataccaga tacagcccat ccttccaagg ccaggtcacc     1380

atctcagccg acagcgccat caacaccgcc tacctgcagt ggagcagcct gaaggcctcg     1440

gacaccgcca tgtattactg tgcgcgccag tctacctaca tctacggtgg ttactacgat     1500

acctggggtc aaggtactct ggtgaccgtc tcctcattcg tgcccgtgtt cctgcccgcc     1560

aaacctacta ctacccctgc acctaggcct cccaccccag ccccaacaat cgccagccag     1620

cctctgtctc tgcggcccga agcctgtaga cctgctgccg gcggagccgt gcacaccaga     1680

ggcctggact tcgcctgcga catctacatc tgggcccctc tggccggcac ctgtggcgtg     1740

ctgctgctga gcctggtgat caccctgtac tgcaaccacc ggaacaaacg gggcagaaag     1800

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1860

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1920

ttcagcagat ccgccgacgc ccctgcctac cagcagggac agaaccagct gtacaacgag     1980

ctgaacctgg gcagacggga agagtacgac gtgctggaca agcggagagg ccgggacccc     2040

gagatgggcg gaaagcccag acggaagaac ccccaggaag gcctgtataa cgaactgcag     2100

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gaggcgcggc     2160

aagggccacg atggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc     2220

ctgcacatgc aggccctgcc ccccaga                                         2247


<210>  56
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9# CAR

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr 
145                 150                 155                 160 


Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp 
                165                 170                 175     


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr 
            180                 185                 190         


His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
        195                 200                 205             


Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
    210                 215                 220                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly 
225                 230                 235                 240 


Tyr Glu Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
            260                 265                 270         


Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
        275                 280                 285             


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
    290                 295                 300                 


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
305                 310                 315                 320 


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
                325                 330                 335     


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            340                 345                 350         


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala 
        355                 360                 365             


Gly Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    370                 375                 380                 


Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala 
385                 390                 395                 400 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                405                 410                 415     


Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro 
            420                 425                 430         


Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp 
        435                 440                 445             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    450                 455                 460                 


Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
465                 470                 475                 480 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly 
                485                 490                 495     


Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510         


Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
        515                 520                 525             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    530                 535                 540                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
545                 550                 555                 560 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                565                 570                 575     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
            580                 585                 590         


His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        595                 600                 605             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    610                 615                 620                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
625                 630                 635                 640 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                645                 650                 655     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            660                 665                 670         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        675                 680                 685             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    690                 695                 700                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
705                 710                 715                 720 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                725                 730                 735     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 


<210>  57
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10# CAR

<400>  57
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccagtctg tcgtgacgca gccgccctca gtgtctgggg ccccagggca gagggtcacc      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt atgatgtaca ctggtaccag      180

caacttccag gaacagcccc caaactcctc atctatgaga acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag cctccctggc catcactggg      300

ctccaggctg aggatgaggc tgattattac tgccagtcct atgacagcag cctgagtggt      360

tggagggtgt tcggcggagg gaccaagctg accgtcctag gtggtggtgg tggtagccag      420

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc      480

tgcactgtct ctggtggctc catcagtagt tactactgga gctggatccg gcagcccgcc      540

gggaagggac tggagtggat tgggcgtatc tataccagtg ggagcaccaa ctacaacccc      600

tccctcaaga gtcgagtcac catgtcagta gacacgtcca agaaccagtt ctccctgaag      660

ctgagctctg tgaccgccgc ggacacggcg gtgtactact gcgccagaga cttgtacaga      720

gatggaatgg acgtatgggg ccagggaaca actgtcaccg tcagctcagg cagcaccagc      780

ggctccggca agcctggctc tggcgagggc agcacaaagg gagacatcca gatgacccag      840

tctccttcca ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggccagt      900

cagagtatta gtagctggtt ggcctggtat cagcagaaac cagggaaagc ccctaagctc      960

ctgatctccg atgcctccag tttggaaagt ggggtcccat caaggttcag cggcagtgga     1020

tctgggacag aattcactct caccatcagc agcctgcagc ctgatgattt tgcaacttat     1080

tactgccagc aggccaatac ctactctcct acttttggcg gagggaccaa ggttgagatc     1140

aaaggtggcg ggggcagcat ggccgaagtg cagctggtgc agtctggggc agaggtgaaa     1200

aagcccgggg agtctctgaa gatctcctgt aaggggtctg gatacagctt taccaactcc     1260

tggatcggat gggtgcgcca gatgcccggg aaaggcctgg agtggatggg actcatttac     1320

cctgatgact ctgataccag atacagccca tccttccaag gccaggtcac catctcagcc     1380

gacagcgcca tcaacaccgc ctacctgcag tggagcagcc tgaaggcctc ggacaccgcc     1440

atgtattact gtgcgcgcca gtctacctac atctacggtg gttactacga tacctggggt     1500

caaggtactc tggtgaccgt ctcctcattc gtgcccgtgt tcctgcccgc caaacctact     1560

actacccctg cacctaggcc tcccacccca gccccaacaa tcgccagcca gcctctgtct     1620

ctgcggcccg aagcctgtag acctgctgcc ggcggagccg tgcacaccag aggcctggac     1680

ttcgcctgcg acatctacat ctgggcccct ctggccggca cctgtggcgt gctgctgctg     1740

agcctggtga tcaccctgta ctgcaaccac cggaacaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcaga     1920

tccgccgacg cccctgccta ccagcaggga cagaaccagc tgtacaacga gctgaacctg     1980

ggcagacggg aagagtacga cgtgctggac aagcggagag gccgggaccc cgagatgggc     2040

ggaaagccca gacggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2100

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgcgg caagggccac     2160

gatggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     2220

caggccctgc cccccaga                                                   2238


<210>  58
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10# CAR

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
145                 150                 155                 160 


Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile 
                165                 170                 175     


Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile Gly Arg Ile Tyr Thr 
            180                 185                 190         


Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met 
        195                 200                 205             


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    210                 215                 220                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Tyr Arg 
225                 230                 235                 240 


Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
            260                 265                 270         


Lys Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
        275                 280                 285             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
    290                 295                 300                 


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
305                 310                 315                 320 


Leu Ile Ser Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
            340                 345                 350         


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Tyr 
        355                 360                 365             


Ser Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
    370                 375                 380                 


Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
385                 390                 395                 400 


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
                405                 410                 415     


Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
            420                 425                 430         


Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr 
        435                 440                 445             


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Ser Ala Ile 
    450                 455                 460                 


Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
465                 470                 475                 480 


Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly Gly Tyr Tyr 
                485                 490                 495     


Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro 
            500                 505                 510         


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        515                 520                 525             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    530                 535                 540                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
545                 550                 555                 560 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                565                 570                 575     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            580                 585                 590         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        595                 600                 605             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    610                 615                 620                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
625                 630                 635                 640 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                645                 650                 655     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            660                 665                 670         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        675                 680                 685             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    690                 695                 700                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
705                 710                 715                 720 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                725                 730                 735     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745     


<210>  59
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11# CAR

<400>  59
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

cccgaaattg tgttgacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc      120

accctctcct gcagggccag tcagagtgtt agcagcagct acttagcctg gtaccagcag      180

aaacctggcc aggctcccag gctcctcatc tatggtgcat ccagcagggc cactggcatc      240

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg      300

gagcctgaag attttgcagt gtattactgt cagcaggccg gactcttccc ttacactttt      360

ggcggaggga ccaaggttga gatcaaaggt ggcgggggca gcatggccga agtgcagctg      420

gtgcagtctg gggcagaggt gaaaaagccc ggggagtctc tgaagatctc ctgtaagggg      480

tctggataca gctttaccaa ctcctggatc ggatgggtgc gccagatgcc cgggaaaggc      540

ctggagtgga tgggactcat ttaccctgat gactctgata ccagatacag cccatccttc      600

caaggccagg tcaccatctc agccgacagc gccatcaaca ccgcctacct gcagtggagc      660

agcctgaagg cctcggacac cgccatgtat tactgtgcgc gccagtctac ctacatctac      720

ggtggttact acgatacctg gggtcaaggt actctggtga ccgtctcctc aggcagcacc      780

agcggctccg gcaagcctgg ctctggcgag ggcagcacaa agggacagtc tgtcgtgacg      840

cagccgccct cagtgtctgg ggccccaggg cagagggtca ccatctcctg cactgggagc      900

agctccaaca tcggggcagg ttatgatgta cactggtacc agcaacttcc aggaacagcc      960

cccaaactcc tcatctatga gaacaccaat cggccctcag gggtccctga ccgattctct     1020

ggctccaagt ctggcacctc agcctccctg gccatcactg ggctccaggc tgaggatgag     1080

gctgattatt actgccagtc ctatgacagc agcctgagtg gttggagggt gttcggcgga     1140

gggaccaagc tgaccgtcct aggtggtggt ggtggtagcc aggtgcagct gcaggagtcg     1200

ggcccaggac tggtgaagcc ttcggggacc ctgtccctca cctgcgctgt ctctggtggc     1260

tccatcagca gtagtaactg gtggagttgg gtccgccagc ccccagggaa ggggctggag     1320

tggattgggg aaatctatca tagtgggagc accaactaca acccgtccct caagagtcga     1380

gtcaccatat cagtagacaa gtccaagaac cagttctccc tgaagctgag ctctgtgacc     1440

gccgcggaca cggcggtgta ctactgcgcc agacttcctg gatacgagtc agctttcgac     1500

atatggggtc agggtacaat ggtcaccgtc agctcattcg tgcccgtgtt cctgcccgcc     1560

aaacctacta ctacccctgc acctaggcct cccaccccag ccccaacaat cgccagccag     1620

cctctgtctc tgcggcccga agcctgtaga cctgctgccg gcggagccgt gcacaccaga     1680

ggcctggact tcgcctgcga catctacatc tgggcccctc tggccggcac ctgtggcgtg     1740

ctgctgctga gcctggtgat caccctgtac tgcaaccacc ggaacaaacg gggcagaaag     1800

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1860

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1920

ttcagcagat ccgccgacgc ccctgcctac cagcagggac agaaccagct gtacaacgag     1980

ctgaacctgg gcagacggga agagtacgac gtgctggaca agcggagagg ccgggacccc     2040

gagatgggcg gaaagcccag acggaagaac ccccaggaag gcctgtataa cgaactgcag     2100

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gaggcgcggc     2160

aagggccacg atggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc     2220

ctgcacatgc aggccctgcc ccccaga                                         2247


<210>  60
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11# CAR

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly 
    130                 135                 140                 


Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly 
145                 150                 155                 160 


Ser Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met 
                165                 170                 175     


Pro Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser 
            180                 185                 190         


Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala 
        195                 200                 205             


Asp Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala 
    210                 215                 220                 


Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr 
225                 230                 235                 240 


Gly Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
            260                 265                 270         


Thr Lys Gly Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala 
        275                 280                 285             


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
    290                 295                 300                 


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
305                 310                 315                 320 


Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro 
                325                 330                 335     


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
            340                 345                 350         


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
        355                 360                 365             


Asp Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr Lys Leu 
    370                 375                 380                 


Thr Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala 
                405                 410                 415     


Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg 
            420                 425                 430         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser 
        435                 440                 445             


Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
    450                 455                 460                 


Val Asp Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
465                 470                 475                 480 


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu 
                485                 490                 495     


Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            500                 505                 510         


Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
        515                 520                 525             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    530                 535                 540                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
545                 550                 555                 560 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                565                 570                 575     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
            580                 585                 590         


His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        595                 600                 605             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    610                 615                 620                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
625                 630                 635                 640 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                645                 650                 655     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            660                 665                 670         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        675                 680                 685             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    690                 695                 700                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
705                 710                 715                 720 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                725                 730                 735     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 


<210>  61
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12# CAR

<400>  61
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

cccgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc      120

accatcactt gccgggccag tcagagtatt agtagctggt tggcctggta tcagcagaaa      180

ccagggaaag cccctaagct cctgatctcc gatgcctcca gtttggaaag tggggtccca      240

tcaaggttca gcggcagtgg atctgggaca gaattcactc tcaccatcag cagcctgcag      300

cctgatgatt ttgcaactta ttactgccag caggccaata cctactctcc tacttttggc      360

ggagggacca aggttgagat caaaggtggc gggggcagca tggccgaagt gcagctggtg      420

cagtctgggg cagaggtgaa aaagcccggg gagtctctga agatctcctg taaggggtct      480

ggatacagct ttaccaactc ctggatcgga tgggtgcgcc agatgcccgg gaaaggcctg      540

gagtggatgg gactcattta ccctgatgac tctgatacca gatacagccc atccttccaa      600

ggccaggtca ccatctcagc cgacagcgcc atcaacaccg cctacctgca gtggagcagc      660

ctgaaggcct cggacaccgc catgtattac tgtgcgcgcc agtctaccta catctacggt      720

ggttactacg atacctgggg tcaaggtact ctggtgaccg tctcctcagg cagcaccagc      780

ggctccggca agcctggctc tggcgagggc agcacaaagg gacagtctgt cgtgacgcag      840

ccgccctcag tgtctggggc cccagggcag agggtcacca tctcctgcac tgggagcagc      900

tccaacatcg gggcaggtta tgatgtacac tggtaccagc aacttccagg aacagccccc      960

aaactcctca tctatgagaa caccaatcgg ccctcagggg tccctgaccg attctctggc     1020

tccaagtctg gcacctcagc ctccctggcc atcactgggc tccaggctga ggatgaggct     1080

gattattact gccagtccta tgacagcagc ctgagtggtt ggagggtgtt cggcggaggg     1140

accaagctga ccgtcctagg tggtggtggt ggtagccagg tgcagctgca ggagtcgggc     1200

ccaggactgg tgaagccttc ggagaccctg tccctcacct gcactgtctc tggtggctcc     1260

atcagtagtt actactggag ctggatccgg cagcccgccg ggaagggact ggagtggatt     1320

gggcgtatct ataccagtgg gagcaccaac tacaacccct ccctcaagag tcgagtcacc     1380

atgtcagtag acacgtccaa gaaccagttc tccctgaagc tgagctctgt gaccgccgcg     1440

gacacggcgg tgtactactg cgccagagac ttgtacagag atggaatgga cgtatggggc     1500

cagggaacaa ctgtcaccgt cagctcattc gtgcccgtgt tcctgcccgc caaacctact     1560

actacccctg cacctaggcc tcccacccca gccccaacaa tcgccagcca gcctctgtct     1620

ctgcggcccg aagcctgtag acctgctgcc ggcggagccg tgcacaccag aggcctggac     1680

ttcgcctgcg acatctacat ctgggcccct ctggccggca cctgtggcgt gctgctgctg     1740

agcctggtga tcaccctgta ctgcaaccac cggaacaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcaga     1920

tccgccgacg cccctgccta ccagcaggga cagaaccagc tgtacaacga gctgaacctg     1980

ggcagacggg aagagtacga cgtgctggac aagcggagag gccgggaccc cgagatgggc     2040

ggaaagccca gacggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     2100

atggccgagg cctacagcga gatcggcatg aagggcgagc ggaggcgcgg caagggccac     2160

gatggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     2220

caggccctgc cccccaga                                                   2238


<210>  62
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12# CAR

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Ser Asp Ala Ser Ser Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 
            100                 105                 110         


Asn Thr Tyr Ser Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala 
    130                 135                 140                 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
145                 150                 155                 160 


Gly Tyr Ser Phe Thr Asn Ser Trp Ile Gly Trp Val Arg Gln Met Pro 
                165                 170                 175     


Gly Lys Gly Leu Glu Trp Met Gly Leu Ile Tyr Pro Asp Asp Ser Asp 
            180                 185                 190         


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
        195                 200                 205             


Ser Ala Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
    210                 215                 220                 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Ile Tyr Gly 
225                 230                 235                 240 


Gly Tyr Tyr Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
            260                 265                 270         


Lys Gly Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro 
        275                 280                 285             


Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly 
    290                 295                 300                 


Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
305                 310                 315                 320 


Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp 
                325                 330                 335     


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr 
            340                 345                 350         


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp 
        355                 360                 365             


Ser Ser Leu Ser Gly Trp Arg Val Phe Gly Gly Gly Thr Lys Leu Thr 
    370                 375                 380                 


Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro 
            420                 425                 430         


Ala Gly Lys Gly Leu Glu Trp Ile Gly Arg Ile Tyr Thr Ser Gly Ser 
        435                 440                 445             


Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp 
    450                 455                 460                 


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Tyr Arg Asp Gly Met 
                485                 490                 495     


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Phe Val Pro 
            500                 505                 510         


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        515                 520                 525             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    530                 535                 540                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
545                 550                 555                 560 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                565                 570                 575     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            580                 585                 590         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        595                 600                 605             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    610                 615                 620                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
625                 630                 635                 640 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                645                 650                 655     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            660                 665                 670         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        675                 680                 685             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    690                 695                 700                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
705                 710                 715                 720 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                725                 730                 735     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745     


<210>  63
<211>  2235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PXL1419 CAR

<400>  63
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccccaggctg tgctgactca gccaccctcg gtgtctgaag cccccaggca gagggtcacc      120

atctcctgtt ctggaagcag ctccaacatc ggaaataatg ctgtaagctg gtaccagcag      180

ctcccaggaa aggctcccaa actcctcatc tattatgatg atctgctccc ctcaggggtc      240

tctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      300

cagtctgagg atgaggctga ttattactgt gcagcatggg atgacagcct gaatggttgg      360

gtgttcggcg gagggaccaa ggtcaccgtc ctaggtggtg gtggtggtag ccaggtgcag      420

ctgcaggagt cgggcccagg actggtgaag ccttcgggga ccctgtccct cacctgcgct      480

gtctctggtg gctccatcag cagtagtaac tggtggagtt gggtccgcca gcccccaggg      540

aaggggctgg agtggattgg ggaaatctat catagtggga gcaccaacta caacccgtcc      600

ctcaagagtc gagtcaccat atcagtagac aagtccaaga accagttctc cctgaagctg      660

agctctgtga ccgccgcgga cacggcggtg tactactgcg ccagacttcc tggatacgag      720

tcagctttcg acatatgggg tcagggtaca atggtcaccg tcagctcagg cagcaccagc      780

ggctccggca agcctggctc tggcgagggc agcacaaagg gagaaattgt gttgacgcag      840

tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt      900

cagagtgtta gcagcagcta cttagcctgg taccagcaga aacctggcca ggctcccagg      960

ctcctcatct atggtgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt     1020

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg     1080

tattactgtc agcaggccgg actcttccct tacacttttg gcggagggac caaggttgag     1140

atcaaaggag gcggagggag tgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag     1200

cccggggagt ctctgaagat ctcctgtaag ggttctggat acagctttac cagctactgg     1260

atcggctggg tgcgccagat gcccgggaaa ggcctggagt ggatggggat catctatcct     1320

ggtgactctg ataccagata cagcccgtcc ttccaaggcc aggtcaccat ctcagccgac     1380

aagtccatca gcaccgccta cctgcagtgg agcagcctga aggcctcgga caccgccatg     1440

tattactgtg cgcgcctgtc ttactcttgg tcttcttggt actgggattt ctggggtcaa     1500

ggtactctgg tgaccgtctc ctcattcgtg cccgtgttcc tgcccgccaa acctactact     1560

acccctgcac ctaggcctcc caccccagcc ccaacaatcg ccagccagcc tctgtctctg     1620

cggcccgaag cctgtagacc tgctgccggc ggagccgtgc acaccagagg cctggacttc     1680

gcctgcgaca tctacatctg ggcccctctg gccggcacct gtggcgtgct gctgctgagc     1740

ctggtgatca ccctgtactg caaccaccgg aacaaacggg gcagaaagaa actcctgtat     1800

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1860

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcagatcc     1920

gccgacgccc ctgcctacca gcagggacag aaccagctgt acaacgagct gaacctgggc     1980

agacgggaag agtacgacgt gctggacaag cggagaggcc gggaccccga gatgggcgga     2040

aagcccagac ggaagaaccc ccaggaaggc ctgtataacg aactgcagaa agacaagatg     2100

gccgaggcct acagcgagat cggcatgaag ggcgagcgga ggcgcggcaa gggccacgat     2160

ggcctgtacc agggcctgag caccgccacc aaggacacct acgacgccct gcacatgcag     2220

gccctgcccc ccaga                                                      2235


<210>  64
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PXL1419 CAR

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Asn Asn Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
                85                  90                  95      


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
            100                 105                 110         


Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
    130                 135                 140                 


Gly Pro Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala 
145                 150                 155                 160 


Val Ser Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg 
                165                 170                 175     


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser 
            180                 185                 190         


Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
        195                 200                 205             


Val Asp Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
    210                 215                 220                 


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu 
225                 230                 235                 240 


Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
            260                 265                 270         


Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
        275                 280                 285             


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
    290                 295                 300                 


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
305                 310                 315                 320 


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
            340                 345                 350         


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Gly Leu 
        355                 360                 365             


Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
    370                 375                 380                 


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
385                 390                 395                 400 


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
                405                 410                 415     


Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
            420                 425                 430         


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
        435                 440                 445             


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
    450                 455                 460                 


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
465                 470                 475                 480 


Tyr Tyr Cys Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp 
                485                 490                 495     


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val 
            500                 505                 510         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        515                 520                 525             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    530                 535                 540                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
545                 550                 555                 560 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                565                 570                 575     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys 
            580                 585                 590         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        595                 600                 605             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    610                 615                 620                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
625                 630                 635                 640 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                645                 650                 655     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            660                 665                 670         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        675                 680                 685             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    690                 695                 700                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
705                 710                 715                 720 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                725                 730                 735     


Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745 


<210>  65
<211>  2235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PXL1435 CAR

<400>  65
atggcacttc ctgtgacagc cttgctcttg cccttagcac tgctgcttca tgcggcgaga       60

cctgaggtcc aacttgtgca atcaggagca gaagtgaaga agccaggcga atcacttaag      120

atttcctgca aaggatcagg atactcattt acatcatact ggatcggatg ggtccggcag      180

atgcccggca aaggattgga gtggatgggc atcatctacc ctggagattc agatacaaga      240

tactcacctt ccttccaagg ccaggtcacc atatcggctg acaaatcaat ctcaacagca      300

taccttcaat ggtcatcact taaagcatca gatacagcaa tgtactactg cgcaaggctt      360

agctattcat ggtcatcatg gtactgggat ttctgggggc aaggcacgct ggttacagtc      420

tcatccggag ggggagggag cgagatcgtc ctcactcagt ctccaggcac cctgtctttg      480

tcacctggag aacgggcaac actttcatgc agagcatcac aaagcgttag tagtagctat      540

cttgcctggt atcagcaaaa accgggccag gcacctagac tgctcattta tggagcttcc      600

tcaagagcaa caggaatccc tgaccggttc agcgggtccg gctctggtac tgatttcacc      660

ttaacaatct caagacttga acctgaagat ttcgcagtgt attattgtca gcaggcagga      720

ctcttcccgt atacattcgg cggaggcaca aaagtggaaa ttaaaggtag tacctccgga      780

tcaggaaagc cgggctctgg agaaggatct acaaagggcc aggttcaact tcaagaatcc      840

ggcccaggtt tggtaaagcc ttcaggtacc ttatcgctga cttgtgcagt gtcaggagga      900

tcaatctcca gtagtaattg gtggtcatgg gtccgacagc ctccagggaa aggactagag      960

tggattggcg agatttacca ctctgggagt accaactaca acccttcact taaatcacga     1020

gtcacaatta gtgttgataa atcaaagaat caattcagcc tcaagctatc atcagtgaca     1080

gcagcagata cagcggtcta ttattgtgct agacttccag gctacgaatc agcatttgat     1140

atctggggac aaggaaccat ggtaactgtt agtagcggag gaggtggctc ccaagcagta     1200

ctgacgcagc cgccctcagt gtcagaggcg ccaaggcaaa gagtaaccat aagttgttct     1260

ggatcttcca gcaatattgg taacaacgca gtgagctggt atcagcagct accgggaaag     1320

gctcccaagc tattgatata ttatgacgat cttcttcctt caggagtgtc agacaggttc     1380

tcgggttcta aatcaggcac atcagcatca cttgccatca gcggcctgca gagcgaagat     1440

gaagcagatt attattgtgc cgcgtgggat gattcactta acggatgggt gttcggcgga     1500

ggcacgaagg tgacagtact tggttttgta cctgtgtttc ttcctgcaaa gccgaccaca     1560

actcccgcac ctagacctcc aactccggca ccaaccattg catcacaacc tctaagtctg     1620

aggcccgagg catgcagacc tgcagcagga ggagcagtgc acacaagagg acttgatttc     1680

gcgtgtgata tctacatctg ggcacccctg gccggaacat gtggagtgct tcttctttca     1740

cttgtgatca cactttactg caaccacaga aacaagcgcg gtagaaagaa gctactgtac     1800

atctttaaac aacctttcat gcgtcctgtg caaacaacac aagaagaaga tggatgctca     1860

tgcagatttc ctgaagaaga agaaggagga tgcgaactta gagtgaaatt cagccgatca     1920

gcagatgcac ctgcatacca acaaggacag aatcagctct ataatgagct gaatttggga     1980

agaagagaag aatacgatgt gcttgataag cgcagaggtc gagacccaga aatgggagga     2040

aagccgagga ggaagaatcc gcaagaagga ctatataatg agctccagaa ggataagatg     2100

gctgaagcat actcagaaat cggaatgaaa ggagaaagaa gaagaggaaa gggccatgat     2160

ggactttacc aaggactttc aacagcaaca aaggacactt acgatgcact tcacatgcaa     2220

gcacttcctc ctaga                                                      2235


<210>  66
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PXL1435 CAR

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr 
        115                 120                 125             


Trp Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
145                 150                 155                 160 


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
                165                 170                 175     


Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            180                 185                 190         


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Gly 
225                 230                 235                 240 


Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
                245                 250                 255     


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
            260                 265                 270         


Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
        275                 280                 285             


Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser 
    290                 295                 300                 


Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
305                 310                 315                 320 


Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
                325                 330                 335     


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe 
            340                 345                 350         


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp Ile Trp Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ala Val 
385                 390                 395                 400 


Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val Thr 
                405                 410                 415     


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Ser 
            420                 425                 430         


Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr 
        435                 440                 445             


Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
    450                 455                 460                 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
465                 470                 475                 480 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp 
                485                 490                 495     


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Phe Val Pro Val 
            500                 505                 510         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        515                 520                 525             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    530                 535                 540                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
545                 550                 555                 560 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                565                 570                 575     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys 
            580                 585                 590         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        595                 600                 605             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    610                 615                 620                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
625                 630                 635                 640 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                645                 650                 655     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            660                 665                 670         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        675                 680                 685             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    690                 695                 700                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
705                 710                 715                 720 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                725                 730                 735     


Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745 


<210>  67
<211>  2235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PXL1436 CAR

<400>  67
atggcacttc ctgtgacagc cttgctcttg cccttagcac tgctgcttca tgcggcgaga       60

cctgagatcg tcctcactca gtctccaggc accctgtctt tgtcacctgg agaacgggca      120

acactttcat gcagagcatc acaaagcgtt agtagtagct atcttgcctg gtatcagcaa      180

aaaccgggcc aggcacctag actgctcatt tatggagctt cctcaagagc aacaggaatc      240

cctgaccggt tcagcgggtc cggctctggt actgatttca ccttaacaat ctcaagactt      300

gaacctgaag atttcgcagt gtattattgt cagcaggcag gactcttccc gtatacattc      360

ggcggaggca caaaagtgga aattaaagga gggggaggga gcgaggtcca acttgtgcaa      420

tcaggagcag aagtgaagaa gccaggcgaa tcacttaaga tttcctgcaa aggatcagga      480

tactcattta catcatactg gatcggatgg gtccggcaga tgcccggcaa aggattggag      540

tggatgggca tcatctaccc tggagattca gatacaagat actcaccttc cttccaaggc      600

caggtcacca tatcggctga caaatcaatc tcaacagcat accttcaatg gtcatcactt      660

aaagcatcag atacagcaat gtactactgc gcaaggctta gctattcatg gtcatcatgg      720

tactgggatt tctgggggca aggcacgctg gttacagtct catccggtag tacctccgga      780

tcaggaaagc cgggctctgg agaaggatct acaaagggcc aagcagtact gacgcagccg      840

ccctcagtgt cagaggcgcc aaggcaaaga gtaaccataa gttgttctgg atcttccagc      900

aatattggta acaacgcagt gagctggtat cagcagctac cgggaaaggc tcccaagcta      960

ttgatatatt atgacgatct tcttccttca ggagtgtcag acaggttctc gggttctaaa     1020

tcaggcacat cagcatcact tgccatcagc ggcctgcaga gcgaagatga agcagattat     1080

tattgtgccg cgtgggatga ttcacttaac ggatgggtgt tcggcggagg cacgaaggtg     1140

acagtacttg gtggaggagg tggctcccag gttcaacttc aagaatccgg cccaggtttg     1200

gtaaagcctt caggtacctt atcgctgact tgtgcagtgt caggaggatc aatctccagt     1260

agtaattggt ggtcatgggt ccgacagcct ccagggaaag gactagagtg gattggcgag     1320

atttaccact ctgggagtac caactacaac ccttcactta aatcacgagt cacaattagt     1380

gttgataaat caaagaatca attcagcctc aagctatcat cagtgacagc agcagataca     1440

gcggtctatt attgtgctag acttccaggc tacgaatcag catttgatat ctggggacaa     1500

ggaaccatgg taactgttag tagctttgta cctgtgtttc ttcctgcaaa gccgaccaca     1560

actcccgcac ctagacctcc aactccggca ccaaccattg catcacaacc tctaagtctg     1620

aggcccgagg catgcagacc tgcagcagga ggagcagtgc acacaagagg acttgatttc     1680

gcgtgtgata tctacatctg ggcacccctg gccggaacat gtggagtgct tcttctttca     1740

cttgtgatca cactttactg caaccacaga aacaagcgcg gtagaaagaa gctactgtac     1800

atctttaaac aacctttcat gcgtcctgtg caaacaacac aagaagaaga tggatgctca     1860

tgcagatttc ctgaagaaga agaaggagga tgcgaactta gagtgaaatt cagccgatca     1920

gcagatgcac ctgcatacca acaaggacag aatcagctct ataatgagct gaatttggga     1980

agaagagaag aatacgatgt gcttgataag cgcagaggtc gagacccaga aatgggagga     2040

aagccgagga ggaagaatcc gcaagaagga ctatataatg agctccagaa ggataagatg     2100

gctgaagcat actcagaaat cggaatgaaa ggagaaagaa gaagaggaaa gggccatgat     2160

ggactttacc aaggactttc aacagcaaca aaggacactt acgatgcact tcacatgcaa     2220

gcacttcctc ctaga                                                      2235


<210>  68
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PXL1436 CAR

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
    130                 135                 140                 


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
145                 150                 155                 160 


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr 
            180                 185                 190         


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
        195                 200                 205             


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
    210                 215                 220                 


Thr Ala Met Tyr Tyr Cys Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp 
225                 230                 235                 240 


Tyr Trp Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                245                 250                 255     


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
            260                 265                 270         


Gly Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg 
        275                 280                 285             


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn 
    290                 295                 300                 


Asn Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
305                 310                 315                 320 


Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe 
                325                 330                 335     


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
            340                 345                 350         


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
        355                 360                 365             


Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
385                 390                 395                 400 


Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly 
                405                 410                 415     


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn 
        435                 440                 445             


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
    450                 455                 460                 


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp 
                485                 490                 495     


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Phe Val Pro Val 
            500                 505                 510         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        515                 520                 525             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    530                 535                 540                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
545                 550                 555                 560 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                565                 570                 575     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys 
            580                 585                 590         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        595                 600                 605             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    610                 615                 620                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
625                 630                 635                 640 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                645                 650                 655     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            660                 665                 670         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        675                 680                 685             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    690                 695                 700                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
705                 710                 715                 720 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                725                 730                 735     


Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745 


<210>  69
<211>  2235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PXL1437 CAR

<400>  69
atggcacttc ctgtgacagc cttgctcttg cccttagcac tgctgcttca tgcggcgaga       60

cctcaggttc aacttcaaga atccggccca ggtttggtaa agccttcagg taccttatcg      120

ctgacttgtg cagtgtcagg aggatcaatc tccagtagta attggtggtc atgggtccga      180

cagcctccag ggaaaggact agagtggatt ggcgagattt accactctgg gagtaccaac      240

tacaaccctt cacttaaatc acgagtcaca attagtgttg ataaatcaaa gaatcaattc      300

agcctcaagc tatcatcagt gacagcagca gatacagcgg tctattattg tgctagactt      360

ccaggctacg aatcagcatt tgatatctgg ggacaaggaa ccatggtaac tgttagtagc      420

ggagggggag ggagccaagc agtactgacg cagccgccct cagtgtcaga ggcgccaagg      480

caaagagtaa ccataagttg ttctggatct tccagcaata ttggtaacaa cgcagtgagc      540

tggtatcagc agctaccggg aaaggctccc aagctattga tatattatga cgatcttctt      600

ccttcaggag tgtcagacag gttctcgggt tctaaatcag gcacatcagc atcacttgcc      660

atcagcggcc tgcagagcga agatgaagca gattattatt gtgccgcgtg ggatgattca      720

cttaacggat gggtgttcgg cggaggcacg aaggtgacag tacttggtgg tagtacctcc      780

ggatcaggaa agccgggctc tggagaagga tctacaaagg gcgaggtcca acttgtgcaa      840

tcaggagcag aagtgaagaa gccaggcgaa tcacttaaga tttcctgcaa aggatcagga      900

tactcattta catcatactg gatcggatgg gtccggcaga tgcccggcaa aggattggag      960

tggatgggca tcatctaccc tggagattca gatacaagat actcaccttc cttccaaggc     1020

caggtcacca tatcggctga caaatcaatc tcaacagcat accttcaatg gtcatcactt     1080

aaagcatcag atacagcaat gtactactgc gcaaggctta gctattcatg gtcatcatgg     1140

tactgggatt tctgggggca aggcacgctg gttacagtct catccggagg aggtggctcc     1200

gagatcgtcc tcactcagtc tccaggcacc ctgtctttgt cacctggaga acgggcaaca     1260

ctttcatgca gagcatcaca aagcgttagt agtagctatc ttgcctggta tcagcaaaaa     1320

ccgggccagg cacctagact gctcatttat ggagcttcct caagagcaac aggaatccct     1380

gaccggttca gcgggtccgg ctctggtact gatttcacct taacaatctc aagacttgaa     1440

cctgaagatt tcgcagtgta ttattgtcag caggcaggac tcttcccgta tacattcggc     1500

ggaggcacaa aagtggaaat taaatttgta cctgtgtttc ttcctgcaaa gccgaccaca     1560

actcccgcac ctagacctcc aactccggca ccaaccattg catcacaacc tctaagtctg     1620

aggcccgagg catgcagacc tgcagcagga ggagcagtgc acacaagagg acttgatttc     1680

gcgtgtgata tctacatctg ggcacccctg gccggaacat gtggagtgct tcttctttca     1740

cttgtgatca cactttactg caaccacaga aacaagcgcg gtagaaagaa gctactgtac     1800

atctttaaac aacctttcat gcgtcctgtg caaacaacac aagaagaaga tggatgctca     1860

tgcagatttc ctgaagaaga agaaggagga tgcgaactta gagtgaaatt cagccgatca     1920

gcagatgcac ctgcatacca acaaggacag aatcagctct ataatgagct gaatttggga     1980

agaagagaag aatacgatgt gcttgataag cgcagaggtc gagacccaga aatgggagga     2040

aagccgagga ggaagaatcc gcaagaagga ctatataatg agctccagaa ggataagatg     2100

gctgaagcat actcagaaat cggaatgaaa ggagaaagaa gaagaggaaa gggccatgat     2160

ggactttacc aaggactttc aacagcaaca aaggacactt acgatgcact tcacatgcaa     2220

gcacttcctc ctaga                                                      2235


<210>  70
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PXL1437 CAR

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg 
145                 150                 155                 160 


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn 
                165                 170                 175     


Asn Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
    210                 215                 220                 


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
225                 230                 235                 240 


Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
                245                 250                 255     


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
            260                 265                 270         


Lys Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
        275                 280                 285             


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
    290                 295                 300                 


Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
305                 310                 315                 320 


Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro 
                325                 330                 335     


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr 
            340                 345                 350         


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp Phe 
    370                 375                 380                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
                405                 410                 415     


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            420                 425                 430         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        435                 440                 445             


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
465                 470                 475                 480 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro 
                485                 490                 495     


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Phe Val Pro Val 
            500                 505                 510         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        515                 520                 525             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    530                 535                 540                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
545                 550                 555                 560 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                565                 570                 575     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys 
            580                 585                 590         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        595                 600                 605             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    610                 615                 620                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
625                 630                 635                 640 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                645                 650                 655     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            660                 665                 670         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        675                 680                 685             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    690                 695                 700                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
705                 710                 715                 720 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                725                 730                 735     


Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745 


