                         б

<110>  Ϊҽҩɷ޹˾
 
<120>  ġHLA-DR׼ƱӦ

<130>  GAI19CN6304P

<150>  202010602241.9
<151>  2020-06-29

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR׵Ħ֮ͦ

<400>  1

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR׵Ħ֮ͦ

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR׵Ħ֮ͦ

<400>  3

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR׵Ħ֮ͦ

<400>  4

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR׵Ħ֮ͦ

<400>  5

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR׵Ħ֮ͦ

<400>  6

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR׵Ħ֮ͦ

<400>  7

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly 
            20  


<210>  8
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1ṹ

<400>  8

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn 
                


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  9

Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg 
1               5                   10                  15      


Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val 
            20                  25                  30          


Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val 
        35                  40                  45              


Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe 
                85                  90                  95      


Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu 
            100                 105         


<210>  10
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1ṹ

<400>  10

Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn Gly Thr Glu 
1               5                   10                  15      


Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu Tyr Val 
            20                  25                  30          


Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly 
        35                  40                  45              


Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln 
    50                  55                  60                  


Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly 
65                  70                  75                  80  


Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys 
                85                  90          


<210>  11
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  11

Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu 
1               5                   10                  15      


Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg 
            20                  25                  30          


Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly 
        35                  40                  45              


Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu 
    50                  55                  60                  


Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro 
65                  70                  75                  80  


Ser Val Thr Ser Pro Leu Thr Val Glu Trp 
                85                  90  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  12

Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys 
1               5                   10  


<210>  13
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  13

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  14
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  14

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Ser Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
        195                 200                 205             


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    210                 215                 220                 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
225                 230                 235                 240 


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                245                 250                 255     


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            260                 265                 270         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        275                 280                 285             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    290                 295                 300                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
305                 310                 315                 320 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                325                 330                 335     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            340                 345                 350         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        355                 360                 365             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    370                 375                 380                 


Gln Ser Lys 
385         


<210>  15
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  15

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Phe Leu Glu Gln Ser Lys Ser Glu Cys 
        195                 200                 205             


His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe 
    210                 215                 220                 


Tyr Asn Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr 
225                 230                 235                 240 


Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 
                245                 250                 255     


Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys 
            260                 265                 270         


Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
        275                 280                 285             


His Pro Lys Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His 
    290                 295                 300                 


His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile 
305                 310                 315                 320 


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val 
                325                 330                 335     


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
            340                 345                 350         


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
        355                 360                 365             


Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg 
    370                 375                 380                 


Ser Glu Ser Ala Gln Ser Lys 
385                 390     


<210>  16
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  16

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Phe 
        195                 200                 205             


Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn Gly Thr Glu Arg 
    210                 215                 220                 


Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu Tyr Val Arg 
225                 230                 235                 240 


Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg 
                245                 250                 255     


Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln Arg 
            260                 265                 270         


Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly Glu 
        275                 280                 285             


Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val Thr Val Tyr Pro 
    290                 295                 300                 


Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val 
305                 310                 315                 320 


Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly 
                325                 330                 335     


Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly 
            340                 345                 350         


Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser 
        355                 360                 365             


Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro 
    370                 375                 380                 


Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys 
385                 390                 395                 


<210>  17
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  17

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Ser Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  18
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  18

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Phe 
    210                 215                 220                 


Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn Gly Thr Glu Arg 
225                 230                 235                 240 


Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu Tyr Val Arg 
                245                 250                 255     


Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg 
            260                 265                 270         


Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln Arg 
        275                 280                 285             


Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly Glu 
    290                 295                 300                 


Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val Thr Val Tyr Pro 
305                 310                 315                 320 


Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val 
                325                 330                 335     


Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly 
            340                 345                 350         


Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly 
        355                 360                 365             


Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser 
    370                 375                 380                 


Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro 
385                 390                 395                 400 


Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys 
                405                 410                 415 


<210>  19
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  19

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Phe 
225                 230                 235                 240 


Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn Gly Thr Glu Arg 
                245                 250                 255     


Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu Tyr Val Arg 
            260                 265                 270         


Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg 
        275                 280                 285             


Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln Arg 
    290                 295                 300                 


Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly Glu 
305                 310                 315                 320 


Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val Thr Val Tyr Pro 
                325                 330                 335     


Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu Val Cys Ser Val 
            340                 345                 350         


Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp Phe Arg Asn Gly 
        355                 360                 365             


Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile Gln Asn Gly 
    370                 375                 380                 


Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr Val Pro Arg Ser 
385                 390                 395                 400 


Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Val Thr Ser Pro 
                405                 410                 415     


Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala Gln Ser Lys 
            420                 425                 430     


<210>  20
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  20

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  21
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  21

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Ser Ser Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  22
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  22

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  23
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  23

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        195                 200                 205             


Ser Gly Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  24
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  24

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Ser Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  25
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  25

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Ser Gly Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  26
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  26

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Ser 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  27
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  27

Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu 
1               5                   10                  15      


Ile Phe His Val Asp Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser 
        35                  40                  45              


Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg 
    50                  55                  60                  


Tyr Phe Tyr Asn Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly 
65                  70                  75                  80  


Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp 
                85                  90                  95      


Asn Ser Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr 
            100                 105                 110         


Tyr Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg 
        115                 120                 125             


Arg Val His Pro Lys Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu 
    130                 135                 140                 


Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly 
145                 150                 155                 160 


Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly 
                165                 170                 175     


Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr 
            180                 185                 190         


Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys 
        195                 200                 205             


Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg 
    210                 215                 220                 


Ala Arg Ser Glu Ser Ala Gln Ser Lys 
225                 230             


<210>  28
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  28

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser 
                85                  90                  95      


Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg 
            100                 105                 110         


Tyr Phe Tyr Asn Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly 
        115                 120                 125             


Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp 
    130                 135                 140                 


Asn Ser Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr 
145                 150                 155                 160 


Tyr Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg 
                165                 170                 175     


Arg Val His Pro Lys Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu 
            180                 185                 190         


Gln His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly 
        195                 200                 205             


Ser Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly 
    210                 215                 220                 


Val Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr 
225                 230                 235                 240 


Leu Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys 
                245                 250                 255     


Gln Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg 
            260                 265                 270         


Ala Arg Ser Glu Ser Ala Gln Ser Lys 
        275                 280     


<210>  29
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  29

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu 
            100                 105                 110         


Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr 
        115                 120                 125             


Phe Tyr Asn Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu 
    130                 135                 140                 


Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn 
145                 150                 155                 160 


Ser Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr 
                165                 170                 175     


Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg 
            180                 185                 190         


Val His Pro Lys Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln 
        195                 200                 205             


His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser 
    210                 215                 220                 


Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val 
225                 230                 235                 240 


Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu 
                245                 250                 255     


Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln 
            260                 265                 270         


Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala 
        275                 280                 285             


Arg Ser Glu Ser Ala Gln Ser Lys 
    290                 295     


<210>  30
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  30

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu 
            180                 185                 190         


Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr 
        195                 200                 205             


Phe Tyr Asn Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu 
    210                 215                 220                 


Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn 
225                 230                 235                 240 


Ser Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr 
                245                 250                 255     


Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg 
            260                 265                 270         


Val His Pro Lys Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln 
        275                 280                 285             


His His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser 
    290                 295                 300                 


Ile Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val 
305                 310                 315                 320 


Val Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu 
                325                 330                 335     


Val Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln 
            340                 345                 350         


Val Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala 
        355                 360                 365             


Arg Ser Glu Ser Ala Gln Ser Lys 
    370                 375     


<210>  31
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  31

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His 
        195                 200                 205             


Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 
    210                 215                 220                 


Asn Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 
225                 230                 235                 240 


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                245                 250                 255     


Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg 
            260                 265                 270         


His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His 
        275                 280                 285             


Pro Lys Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His 
    290                 295                 300                 


Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
305                 310                 315                 320 


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser 
                325                 330                 335     


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
            340                 345                 350         


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
        355                 360                 365             


His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
    370                 375                 380                 


Glu Ser Ala Gln Ser Lys 
385                 390 


<210>  32
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  32

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp 
385                 390             


<210>  33
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  33

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr 
    370                 375         


<210>  34
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  34

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys 
    290                 295                 300             


<210>  35
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  35

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ala Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  36
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  36

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Ala Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ala Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  37
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  37

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ala Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  38
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  38

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ala Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ala Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  39
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  39

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Ala Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ala Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  40
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  40

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Ala Ala Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Ser Gly Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn 
    210                 215                 220                 


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
225                 230                 235                 240 


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
                245                 250                 255     


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
            260                 265                 270         


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
        275                 280                 285             


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
    290                 295                 300                 


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
305                 310                 315                 320 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
                325                 330                 335     


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
            340                 345                 350         


Ile Gln Asn Gly Asp Ala Ala Phe Gln Thr Leu Val Met Leu Glu Thr 
        355                 360                 365             


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
    370                 375                 380                 


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Gln Ser Lys 
            


<210>  41
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1ṹ

<400>  41

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Ala Ala Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn 
                


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  42

Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg 
1               5                   10                  15      


Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val 
            20                  25                  30          


Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val 
        35                  40                  45              


Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe 
                85                  90                  95      


Asp Ala Pro Ala Pro Leu Pro Glu Thr Thr Glu 
            100                 105         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  43

Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg 
1               5                   10                  15      


Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val 
            20                  25                  30          


Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Ala Gly Val 
        35                  40                  45              


Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe 
                85                  90                  95      


Asp Ala Pro Ala Pro Leu Pro Glu Thr Thr Glu 
            100                 105         


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  44

Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg 
1               5                   10                  15      


Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val 
            20                  25                  30          


Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val 
        35                  40                  45              


Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Ala Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe 
                85                  90                  95      


Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu 
            100                 105         


<210>  45
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1ṹ

<400>  45

Phe Leu Glu Gln Ser Lys Ser Glu Cys His Phe Phe Asn Gly Thr Glu 
1               5                   10                  15      


Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu Tyr Val 
            20                  25                  30          


Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly 
        35                  40                  45              


Arg Pro Asp Ala Glu Tyr Trp Asn Ala Gln Lys Asp Leu Leu Glu Gln 
    50                  55                  60                  


Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly 
65                  70                  75                  80  


Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys 
                85                  90          


<210>  46
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  46

Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu 
1               5                   10                  15      


Leu Val Cys Ala Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg 
            20                  25                  30          


Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly 
        35                  40                  45              


Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu 
    50                  55                  60                  


Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro 
65                  70                  75                  80  


Ser Val Thr Ser Pro Leu Thr Val Glu Trp 
                85                  90  


<210>  47
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  47

Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu 
1               5                   10                  15      


Leu Val Cys Ser Val Ala Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg 
            20                  25                  30          


Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly 
        35                  40                  45              


Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu 
    50                  55                  60                  


Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro 
65                  70                  75                  80  


Ser Val Thr Ser Pro Leu Thr Val Glu Trp 
                85                  90  


<210>  48
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2ṹ

<400>  48

Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu 
1               5                   10                  15      


Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg 
            20                  25                  30          


Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly 
        35                  40                  45              


Leu Ile Gln Asn Gly Asp Ala Ala Phe Gln Thr Leu Val Met Leu Glu 
    50                  55                  60                  


Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro 
65                  70                  75                  80  


Ser Val Thr Ser Pro Leu Thr Val Glu Trp 
                85                  90  


<210>  49
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-DRצ

<400>  49
atcaaagaag aacatgtgat catccaggcc gagttctatc tgaatcctga ccaatcaggc       60

gagtttatgt ttgactttga tggtgatgag attttccatg tggatatggc aaagaaggag      120

acggtctggc ggcttgaaga atttggacga tttgccagct ttgaggctca aggtgcattg      180

gccaacatag ctgtggacaa agccaacctg gaaatcatga caaagcgctc caactatact      240

ccgatcacca atgtacctcc agaggtaact gtgctcacaa acagccctgt ggaactgaga      300

gagcccaacg tcctcatctg tttcatagac aagttcaccc caccagtggt caatgtcacg      360

tggcttcgaa atggaaaacc tgtcaccaca ggagtgtcag agacagtctt cctgcccagg      420

gaagaccacc ttttccgcaa gttccactat ctccccttcc tgccctcaac tgaggacgtt      480

tacgactgca gggtggagca ctggggcttg gatgagcctc ttctcaagca ctgggagttt      540

gatgctccaa gccctctccc agagactaca gag                                   573


<210>  50
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-DRצ

<400>  50
tttctggaac agtccaaaag cgagtgccac ttcttcaacg gtaccgaacg cgttcgtttt       60

ctggatcgct acttctacaa ccaggaagaa tatgtccgct ttgattctga cgttggcgaa      120

tatcgcgcag ttaccgaact gggtcgtccg gacgcagaat attggaacag ccagaaagac      180

ctgctggaac aacgtcgcgc agcagttgat acctattgtc gtcataacta cggcgttggc      240

gaaagtttca ccgttcaacg tcgcgttcat ccgaaagtta ccgtttatcc ggcgaaaacc      300

caaccgctgc aacatcataa cctgctggtt tgcagcgtaa gcggctttta tccgggcagc      360

attgaagtac gctggtttcg taacggtcag gaagaaaaag cgggcgttgt tagtaccggt      420

ctgattcaga acggcgattg gacctttcaa accctggtta tgctggaaac cgttccgcgt      480

tctggcgaag tttatacctg ccaggtcgaa catccgtctg ttaccagtcc gctgaccgtt      540

gaatggcgtg cacgttctga atctgcacag agcaaa                                576


<210>  51
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-DR

<400>  51
ggatccgcca ccatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt       60

gtcacgaatt cgatcaaaga agaacatgtg atcatccagg ccgagttcta tctgaatcct      120

gaccaatcag gcgagtttat gtttgacttt gatggtgatg agattttcca tgtggatatg      180

gcaaagaagg agacggtctg gcggcttgaa gaatttggac gatttgccag ctttgaggct      240

caaggtgcat tggccaacat agctgtggac aaagccaacc tggaaatcat gacaaagcgc      300

tccaactata ctccgatcac caatgtacct ccagaggtaa ctgtgctcac aaacagccct      360

gtggaactga gagagcccaa cgtcctcatc tgtttcatag acaagttcac cccaccagtg      420

gtcaatgtca cgtggcttcg aaatggaaaa cctgtcacca caggagtgtc agagacagtc      480

ttcctgccca gggaagacca ccttttccgc aagttccact atctcccctt cctgccctca      540

actgaggacg tttacgactg cagggtggag cactggggct tggatgagcc tcttctcaag      600

cactgggagt ttgatgctcc aagccctctc ccagagacta cagagggcgg tggtagcggc      660

ggtggcagcg gcggtggtag cggcggtggc agcggcggtg gtagctttct ggaacagtcc      720

aaaagcgagt gccacttctt caacggtacc gaacgcgttc gttttctgga tcgctacttc      780

tacaaccagg aagaatatgt ccgctttgat tctgacgttg gcgaatatcg cgcagttacc      840

gaactgggtc gtccggacgc agaatattgg aacagccaga aagacctgct ggaacaacgt      900

cgcgcagcag ttgataccta ttgtcgtcat aactacggcg ttggcgaaag tttcaccgtt      960

caacgtcgcg ttcatccgaa agttaccgtt tatccggcga aaacccaacc gctgcaacat     1020

cataacctgc tggtttgcag cgtaagcggc ttttatccgg gcagcattga agtacgctgg     1080

tttcgtaacg gtcaggaaga aaaagcgggc gttgttagta ccggtctgat tcagaacggc     1140

gattggacct ttcaaaccct ggttatgctg gaaaccgttc cgcgttctgg cgaagtttat     1200

acctgccagg tcgaacatcc gtctgttacc agtccgctga ccgttgaatg gcgtgcacgt     1260

tctgaatctg cacagagcaa acatcaccat caccaccatc atcaccatca ctaactcgag     1320


