                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  LIVE CELL ENGAGEMENT ASSAY

<130>  104593-5033-WO

<140>  PCT/US2021/039221
<141>  2021-06-25

<150>  63/044,338
<151>  2020-06-25

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp 
1               5                   10                  15      


Gly Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala 
            20                  25                  30          


Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys 
        35                  40                  45              


Arg Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys 
    50                  55                  60                  


Asp Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly 
65                  70                  75                  80  


Val Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg 
                85                  90                  95      


Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile 
            100                 105                 110         


Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly 
        115                 120                 125             


Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu 
    130                 135                 140                 


His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg 
145                 150                 155                 160 


Ile Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly 
                165                 170                 175     


Leu Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp 
        195                 200                 205             


Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val 
    210                 215                 220                 


Gly Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr 
225                 230                 235                 240 


Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met 
                245                 250                 255     


Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu 
            260                 265                 270         


Leu Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro 
        275                 280                 285             


Arg Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser 
    290                 295                 300                 


Arg Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu 
305                 310                 315                 320 


Pro Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp 
                325                 330                 335     


Phe Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu 
            340                 345                 350         


Lys Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu 
        355                 360                 365             


Val Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro 
    370                 375                 380                 


Ser Thr Pro Thr His Ala Ala Gly Val 
385                 390             


<210>  2
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Ala Arg Arg Lys Pro Val Leu Pro Ala Leu Thr Ile Asn Pro 
1               5                   10                  15      


Thr Ile Ala Glu Gly Pro Ser Pro Thr Ser Glu Gly Ala Ser Glu Ala 
            20                  25                  30          


Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu 
        35                  40                  45              


Gln Gln Lys Lys Arg Leu Glu Ala Phe Leu Thr Gln Lys Ala Lys Val 
    50                  55                  60                  


Gly Glu Leu Lys Asp Asp Asp Phe Glu Arg Ile Ser Glu Leu Gly Ala 
65                  70                  75                  80  


Gly Asn Gly Gly Val Val Thr Lys Val Gln His Arg Pro Ser Gly Leu 
                85                  90                  95      


Ile Met Ala Arg Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg 
            100                 105                 110         


Asn Gln Ile Ile Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro 
        115                 120                 125             


Tyr Ile Val Gly Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser 
    130                 135                 140                 


Ile Cys Met Glu His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys 
145                 150                 155                 160 


Glu Ala Lys Arg Ile Pro Glu Glu Ile Leu Gly Lys Val Ser Ile Ala 
                165                 170                 175     


Val Leu Arg Gly Leu Ala Tyr Leu Arg Glu Lys His Gln Ile Met His 
            180                 185                 190         


Arg Asp Val Lys Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile 
        195                 200                 205             


Lys Leu Cys Asp Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala 
    210                 215                 220                 


Asn Ser Phe Val Gly Thr Arg Ser Tyr Met Ala Pro Glu Arg Leu Gln 
225                 230                 235                 240 


Gly Thr His Tyr Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser 
                245                 250                 255     


Leu Val Glu Leu Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala 
            260                 265                 270         


Lys Glu Leu Glu Ala Ile Phe Gly Arg Pro Val Val Asp Gly Glu Glu 
        275                 280                 285             


Gly Glu Pro His Ser Ile Ser Pro Arg Pro Arg Pro Pro Gly Arg Pro 
    290                 295                 300                 


Val Ser Gly His Gly Met Asp Ser Arg Pro Ala Met Ala Ile Phe Glu 
305                 310                 315                 320 


Leu Leu Asp Tyr Ile Val Asn Glu Pro Pro Pro Lys Leu Pro Asn Gly 
                325                 330                 335     


Val Phe Thr Pro Asp Phe Gln Glu Phe Val Asn Lys Cys Leu Ile Lys 
            340                 345                 350         


Asn Pro Ala Glu Arg Ala Asp Leu Lys Met Leu Thr Asn His Thr Phe 
        355                 360                 365             


Ile Lys Arg Ser Glu Val Glu Glu Val Asp Phe Ala Gly Trp Leu Cys 
    370                 375                 380                 


Lys Thr Leu Arg Leu Asn Gln Pro Gly Thr Pro Thr Arg Thr Ala Val 
385                 390                 395                 400 


<210>  3
<211>  393
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp 
1               5                   10                  15      


Gly Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala 
            20                  25                  30          


Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys 
        35                  40                  45              


Arg Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys 
    50                  55                  60                  


Asp Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly 
65                  70                  75                  80  


Val Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg 
                85                  90                  95      


Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile 
            100                 105                 110         


Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly 
        115                 120                 125             


Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu 
    130                 135                 140                 


His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg 
145                 150                 155                 160 


Ile Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly 
                165                 170                 175     


Leu Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp 
        195                 200                 205             


Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val 
    210                 215                 220                 


Gly Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr 
225                 230                 235                 240 


Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met 
                245                 250                 255     


Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu 
            260                 265                 270         


Leu Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro 
        275                 280                 285             


Arg Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser 
    290                 295                 300                 


Arg Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu 
305                 310                 315                 320 


Pro Pro Pro Lys Leu Pro Ser Ala Val Phe Ser Leu Glu Phe Gln Asp 
                325                 330                 335     


Phe Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu 
            340                 345                 350         


Lys Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu 
        355                 360                 365             


Val Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro 
    370                 375                 380                 


Ser Thr Pro Thr His Ala Ala Gly Val 
385                 390             


<210>  4
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Arg Ala Ala Leu Arg Ala Ala Ala Met Gly Glu Lys Lys Glu 
1               5                   10                  15      


Gly Gly Gly Gly Gly Asp Ala Ala Ala Ala Glu Gly Gly Ala Gly Ala 
            20                  25                  30          


Ala Ala Ser Arg Ala Leu Gln Gln Cys Gly Gln Leu Gln Lys Leu Ile 
        35                  40                  45              


Asp Ile Ser Ile Gly Ser Leu Arg Gly Leu Arg Thr Lys Cys Ala Val 
    50                  55                  60                  


Ser Asn Asp Leu Thr Gln Gln Glu Ile Arg Thr Leu Glu Ala Lys Leu 
65                  70                  75                  80  


Val Arg Tyr Ile Cys Lys Gln Arg Gln Cys Lys Leu Ser Val Ala Pro 
                85                  90                  95      


Gly Glu Arg Thr Pro Glu Leu Asn Ser Tyr Pro Arg Phe Ser Asp Trp 
            100                 105                 110         


Leu Tyr Thr Phe Asn Val Arg Pro Glu Val Val Gln Glu Ile Pro Arg 
        115                 120                 125             


Asp Leu Thr Leu Asp Ala Leu Leu Glu Met Asn Glu Ala Lys Val Lys 
    130                 135                 140                 


Glu Thr Leu Arg Arg Cys Gly Ala Ser Gly Asp Glu Cys Gly Arg Leu 
145                 150                 155                 160 


Gln Tyr Ala Leu Thr Cys Leu Arg Lys Val Thr Gly Leu Gly Gly Glu 
                165                 170                 175     


His Lys Glu Asp Ser Ser Trp Ser Ser Leu Asp Ala Arg Arg Glu Ser 
            180                 185                 190         


Gly Ser Gly Pro Ser Thr Asp Thr Leu Ser Ala Ala Ser Leu Pro Trp 
        195                 200                 205             


Pro Pro Gly Ser Ser Gln Leu Gly Arg Ala Gly Asn Ser Ala Gln Gly 
    210                 215                 220                 


Pro Arg Ser Ile Ser Val Ser Ala Leu Pro Ala Ser Asp Ser Pro Thr 
225                 230                 235                 240 


Pro Ser Phe Ser Glu Gly Leu Ser Asp Thr Cys Ile Pro Leu His Ala 
                245                 250                 255     


Ser Gly Arg Leu Thr Pro Arg Ala Leu His Ser Phe Ile Thr Pro Pro 
            260                 265                 270         


Thr Thr Pro Gln Leu Arg Arg His Thr Lys Leu Lys Pro Pro Arg Thr 
        275                 280                 285             


Pro Pro Pro Pro Ser Arg Lys Val Phe Gln Leu Leu Pro Ser Phe Pro 
    290                 295                 300                 


Thr Leu Thr Arg Ser Lys Ser His Glu Ser Gln Leu Gly Asn Arg Ile 
305                 310                 315                 320 


Asp Asp Val Ser Ser Met Arg Phe Asp Leu Ser His Gly Ser Pro Gln 
                325                 330                 335     


Met Val Arg Arg Asp Ile Gly Leu Ser Val Thr His Arg Phe Ser Thr 
            340                 345                 350         


Lys Ser Trp Leu Ser Gln Val Cys His Val Cys Gln Lys Ser Met Ile 
        355                 360                 365             


Phe Gly Val Lys Cys Lys His Cys Arg Leu Lys Cys His Asn Lys Cys 
    370                 375                 380                 


Thr Lys Glu Ala Pro Ala Cys Arg Ile Ser Phe Leu Pro Leu Thr Arg 
385                 390                 395                 400 


Leu Arg Arg Thr Glu Ser Val Pro Ser Asp Ile Asn Asn Pro Val Asp 
                405                 410                 415     


Arg Ala Ala Glu Pro His Phe Gly Thr Leu Pro Lys Ala Leu Thr Lys 
            420                 425                 430         


Lys Glu His Pro Pro Ala Met Asn His Leu Asp Ser Ser Ser Asn Pro 
        435                 440                 445             


Ser Ser Thr Thr Ser Ser Thr Pro Ser Ser Pro Ala Pro Phe Pro Thr 
    450                 455                 460                 


Ser Ser Asn Pro Ser Ser Ala Thr Thr Pro Pro Asn Pro Ser Pro Gly 
465                 470                 475                 480 


Gln Arg Asp Ser Arg Phe Asn Phe Pro Ala Ala Tyr Phe Ile His His 
                485                 490                 495     


Arg Gln Gln Phe Ile Phe Pro Val Pro Ser Ala Gly His Cys Trp Lys 
            500                 505                 510         


Cys Leu Leu Ile Ala Glu Ser Leu Lys Glu Asn Ala Phe Asn Ile Ser 
        515                 520                 525             


Ala Phe Ala His Ala Ala Pro Leu Pro Glu Ala Ala Asp Gly Thr Arg 
    530                 535                 540                 


Leu Asp Asp Gln Pro Lys Ala Asp Val Leu Glu Ala His Glu Ala Glu 
545                 550                 555                 560 


Ala Glu Glu Pro Glu Ala Gly Lys Ser Glu Ala Glu Asp Asp Glu Asp 
                565                 570                 575     


Glu Val Asp Asp Leu Pro Ser Ser Arg Arg Pro Trp Arg Gly Pro Ile 
            580                 585                 590         


Ser Arg Lys Ala Ser Gln Thr Ser Val Tyr Leu Gln Glu Trp Asp Ile 
        595                 600                 605             


Pro Phe Glu Gln Val Glu Leu Gly Glu Pro Ile Gly Gln Gly Arg Trp 
    610                 615                 620                 


Gly Arg Val His Arg Gly Arg Trp His Gly Glu Val Ala Ile Arg Leu 
625                 630                 635                 640 


Leu Glu Met Asp Gly His Asn Gln Asp His Leu Lys Leu Phe Lys Lys 
                645                 650                 655     


Glu Val Met Asn Tyr Arg Gln Thr Arg His Glu Asn Val Val Leu Phe 
            660                 665                 670         


Met Gly Ala Cys Met Asn Pro Pro His Leu Ala Ile Ile Thr Ser Phe 
        675                 680                 685             


Cys Lys Gly Arg Thr Leu His Ser Phe Val Arg Asp Pro Lys Thr Ser 
    690                 695                 700                 


Leu Asp Ile Asn Lys Thr Arg Gln Ile Ala Gln Glu Ile Ile Lys Gly 
705                 710                 715                 720 


Met Gly Tyr Leu His Ala Lys Gly Ile Val His Lys Asp Leu Lys Ser 
                725                 730                 735     


Lys Asn Val Phe Tyr Asp Asn Gly Lys Val Val Ile Thr Asp Phe Gly 
            740                 745                 750         


Leu Phe Gly Ile Ser Gly Val Val Arg Glu Gly Arg Arg Glu Asn Gln 
        755                 760                 765             


Leu Lys Leu Ser His Asp Trp Leu Cys Tyr Leu Ala Pro Glu Ile Val 
    770                 775                 780                 


Arg Glu Met Thr Pro Gly Lys Asp Glu Asp Gln Leu Pro Phe Ser Lys 
785                 790                 795                 800 


Ala Ala Asp Val Tyr Ala Phe Gly Thr Val Trp Tyr Glu Leu Gln Ala 
                805                 810                 815     


Arg Asp Trp Pro Leu Lys Asn Gln Ala Ala Glu Ala Ser Ile Trp Gln 
            820                 825                 830         


Ile Gly Ser Gly Glu Gly Met Lys Arg Val Leu Thr Ser Val Ser Leu 
        835                 840                 845             


Gly Lys Glu Val Ser Glu Ile Leu Ser Ala Cys Trp Ala Phe Asp Leu 
    850                 855                 860                 


Gln Glu Arg Pro Ser Phe Ser Leu Leu Met Asp Met Leu Glu Lys Leu 
865                 870                 875                 880 


Pro Lys Leu Asn Arg Arg Leu Ser His Pro Gly His Phe Trp Lys Ser 
                885                 890                 895     


Ala Asp Ile Asn Ser Ser Lys Val Val Pro Arg Phe Glu Arg Phe Gly 
            900                 905                 910         


Leu Gly Val Leu Glu Ser Ser Asn Pro Lys Met 
        915                 920             


<210>  5
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Glu Glu Asn Met Thr Lys Ser Glu Glu Gln Gln Pro Leu Ser 
1               5                   10                  15      


Leu Gln Lys Ala Leu Gln Gln Cys Glu Leu Val Gln Asn Met Ile Asp 
            20                  25                  30          


Leu Ser Ile Ser Asn Leu Glu Gly Leu Arg Thr Lys Cys Ala Thr Ser 
        35                  40                  45              


Asn Asp Leu Thr Gln Lys Glu Ile Arg Thr Leu Glu Ser Lys Leu Val 
    50                  55                  60                  


Lys Tyr Phe Ser Arg Gln Leu Ser Cys Lys Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Glu Arg Asn Ala Glu Leu Asp Gly Phe Pro Gln Leu Arg His Trp Phe 
                85                  90                  95      


Arg Ile Val Asp Val Arg Lys Glu Val Leu Glu Glu Ile Ser Pro Gly 
            100                 105                 110         


Gln Leu Ser Leu Glu Asp Leu Leu Glu Met Thr Asp Glu Gln Val Cys 
        115                 120                 125             


Glu Thr Val Glu Lys Tyr Gly Ala Asn Arg Glu Glu Cys Ala Arg Leu 
    130                 135                 140                 


Asn Ala Ser Leu Ser Cys Leu Arg Asn Val His Met Ser Gly Gly Asn 
145                 150                 155                 160 


Leu Ser Lys Gln Asp Trp Thr Ile Gln Trp Pro Thr Thr Glu Thr Gly 
                165                 170                 175     


Lys Glu Asn Asn Pro Val Cys Pro Pro Glu Pro Thr Pro Trp Ile Arg 
            180                 185                 190         


Thr His Leu Ser Gln Ser Pro Arg Val Pro Ser Lys Cys Val Gln His 
        195                 200                 205             


Tyr Cys His Thr Ser Pro Thr Pro Gly Ala Pro Val Tyr Thr His Val 
    210                 215                 220                 


Asp Arg Leu Thr Val Asp Ala Tyr Pro Gly Leu Cys Pro Pro Pro Pro 
225                 230                 235                 240 


Leu Glu Ser Gly His Arg Ser Leu Pro Pro Ser Pro Arg Gln Arg His 
                245                 250                 255     


Ala Val Arg Thr Pro Pro Arg Thr Pro Asn Ile Val Thr Thr Val Thr 
            260                 265                 270         


Pro Pro Gly Thr Pro Pro Met Arg Lys Lys Asn Lys Leu Lys Pro Pro 
        275                 280                 285             


Gly Thr Pro Pro Pro Ser Ser Arg Lys Leu Ile His Leu Ile Pro Gly 
    290                 295                 300                 


Phe Thr Ala Leu His Arg Ser Lys Ser His Glu Phe Gln Leu Gly His 
305                 310                 315                 320 


Arg Val Asp Glu Ala His Thr Pro Lys Ala Lys Lys Lys Ser Lys Pro 
                325                 330                 335     


Leu Asn Leu Lys Ile His Ser Ser Val Gly Ser Cys Glu Asn Ile Pro 
            340                 345                 350         


Ser Gln Gln Arg Ser Pro Leu Leu Ser Glu Arg Ser Leu Arg Ser Phe 
        355                 360                 365             


Phe Val Gly His Ala Pro Phe Leu Pro Ser Thr Pro Pro Val His Thr 
    370                 375                 380                 


Glu Ala Asn Phe Ser Ala Asn Thr Leu Ser Val Pro Arg Trp Ser Pro 
385                 390                 395                 400 


Gln Ile Pro Arg Arg Asp Leu Gly Asn Ser Ile Lys His Arg Phe Ser 
                405                 410                 415     


Thr Lys Tyr Trp Met Ser Gln Thr Cys Thr Val Cys Gly Lys Gly Met 
            420                 425                 430         


Leu Phe Gly Leu Lys Cys Lys Asn Cys Lys Leu Lys Cys His Asn Lys 
        435                 440                 445             


Cys Thr Lys Glu Ala Pro Pro Cys His Leu Leu Ile Ile His Arg Gly 
    450                 455                 460                 


Asp Pro Ala Arg Leu Val Arg Thr Glu Ser Val Pro Cys Asp Ile Asn 
465                 470                 475                 480 


Asn Pro Leu Arg Lys Pro Pro Arg Tyr Ser Asp Leu His Ile Ser Gln 
                485                 490                 495     


Thr Leu Pro Lys Thr Asn Lys Ile Asn Lys Asp His Ile Pro Val Pro 
            500                 505                 510         


Tyr Gln Pro Asp Ser Ser Ser Asn Pro Ser Ser Thr Thr Ser Ser Thr 
        515                 520                 525             


Pro Ser Ser Pro Ala Pro Pro Leu Pro Pro Ser Ala Thr Pro Pro Ser 
    530                 535                 540                 


Pro Leu His Pro Ser Pro Gln Cys Thr Arg Gln Gln Lys Asn Phe Asn 
545                 550                 555                 560 


Leu Pro Ala Ser His Tyr Tyr Lys Tyr Lys Gln Gln Phe Ile Phe Pro 
                565                 570                 575     


Asp Val Val Pro Val Pro Glu Thr Pro Thr Arg Ala Pro Gln Val Ile 
            580                 585                 590         


Leu His Pro Val Thr Ser Asn Pro Ile Leu Glu Gly Asn Pro Leu Leu 
        595                 600                 605             


Gln Ile Glu Val Glu Pro Thr Ser Glu Asn Glu Glu Val His Asp Glu 
    610                 615                 620                 


Ala Glu Glu Ser Glu Asp Asp Phe Glu Glu Met Asn Leu Ser Leu Leu 
625                 630                 635                 640 


Ser Ala Arg Ser Phe Pro Arg Lys Ala Ser Gln Thr Ser Ile Phe Leu 
                645                 650                 655     


Gln Glu Trp Asp Ile Pro Phe Glu Gln Leu Glu Ile Gly Glu Leu Ile 
            660                 665                 670         


Gly Lys Gly Arg Phe Gly Gln Val Tyr His Gly Arg Trp His Gly Glu 
        675                 680                 685             


Val Ala Ile Arg Leu Ile Asp Ile Glu Arg Asp Asn Glu Asp Gln Leu 
    690                 695                 700                 


Lys Ala Phe Lys Arg Glu Val Met Ala Tyr Arg Gln Thr Arg His Glu 
705                 710                 715                 720 


Asn Val Val Leu Phe Met Gly Ala Cys Met Ser Pro Pro His Leu Ala 
                725                 730                 735     


Ile Ile Thr Ser Leu Cys Lys Gly Arg Thr Leu Tyr Ser Val Val Arg 
            740                 745                 750         


Asp Ala Lys Ile Val Leu Asp Val Asn Lys Thr Arg Gln Ile Ala Gln 
        755                 760                 765             


Glu Ile Val Lys Gly Met Gly Tyr Leu His Ala Lys Gly Ile Leu His 
    770                 775                 780                 


Lys Asp Leu Lys Ser Lys Asn Val Phe Tyr Asp Asn Gly Lys Val Val 
785                 790                 795                 800 


Ile Thr Asp Phe Gly Leu Phe Ser Ile Ser Gly Val Leu Gln Ala Gly 
                805                 810                 815     


Arg Arg Glu Asp Lys Leu Arg Ile Gln Asn Gly Trp Leu Cys His Leu 
            820                 825                 830         


Ala Pro Glu Ile Ile Arg Gln Leu Ser Pro Asp Thr Glu Glu Asp Lys 
        835                 840                 845             


Leu Pro Phe Ser Lys His Ser Asp Val Phe Ala Leu Gly Thr Ile Trp 
    850                 855                 860                 


Tyr Glu Leu His Ala Arg Glu Trp Pro Phe Lys Thr Gln Pro Ala Glu 
865                 870                 875                 880 


Ala Ile Ile Trp Gln Met Gly Thr Gly Met Lys Pro Asn Leu Ser Gln 
                885                 890                 895     


Ile Gly Met Gly Lys Glu Ile Ser Asp Ile Leu Leu Phe Cys Trp Ala 
            900                 905                 910         


Phe Glu Gln Glu Glu Arg Pro Thr Phe Thr Lys Leu Met Asp Met Leu 
        915                 920                 925             


Glu Lys Leu Pro Lys Arg Asn Arg Arg Leu Ser His Pro Gly His Phe 
    930                 935                 940                 


Trp Lys Ser Ala Glu Leu 
945                 950 


<210>  6
<211>  873
<212>  PRT
<213>  Mus musculus

<400>  6

Met Asp Arg Ala Ala Leu Arg Ala Ala Ala Met Gly Glu Lys Lys Glu 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ala Ala Ala Asp Gly Gly Ala Gly Ala Ala Val 
            20                  25                  30          


Ser Arg Ala Leu Gln Gln Cys Gly Gln Leu Gln Lys Leu Ile Asp Ile 
        35                  40                  45              


Ser Ile Gly Ser Leu Arg Gly Leu Arg Thr Lys Cys Ser Val Ser Asn 
    50                  55                  60                  


Asp Leu Thr Gln Gln Glu Ile Arg Thr Leu Glu Ala Lys Leu Val Lys 
65                  70                  75                  80  


Tyr Ile Cys Lys Gln Gln Gln Ser Lys Leu Ser Val Thr Pro Ser Asp 
                85                  90                  95      


Arg Thr Ala Glu Leu Asn Ser Tyr Pro Arg Phe Ser Asp Trp Leu Tyr 
            100                 105                 110         


Ile Phe Asn Val Arg Pro Glu Val Val Gln Glu Ile Pro Gln Glu Leu 
        115                 120                 125             


Thr Leu Asp Ala Leu Leu Glu Met Asp Glu Ala Lys Ala Lys Glu Met 
    130                 135                 140                 


Leu Arg Arg Trp Gly Ala Ser Thr Glu Glu Cys Ser Arg Leu Gln Gln 
145                 150                 155                 160 


Ala Leu Thr Cys Leu Arg Lys Val Thr Gly Leu Gly Gly Glu His Lys 
                165                 170                 175     


Met Asp Ser Gly Trp Ser Ser Thr Asp Ala Arg Asp Ser Ser Leu Gly 
            180                 185                 190         


Pro Pro Met Asp Met Leu Ser Ser Leu Gly Arg Ala Gly Ala Ser Thr 
        195                 200                 205             


Gln Gly Pro Arg Ser Ile Ser Val Ser Ala Leu Pro Ala Ser Asp Ser 
    210                 215                 220                 


Pro Val Pro Gly Leu Ser Glu Gly Leu Ser Asp Ser Cys Ile Pro Leu 
225                 230                 235                 240 


His Thr Ser Gly Arg Leu Thr Pro Arg Ala Leu His Ser Phe Ile Thr 
                245                 250                 255     


Pro Pro Thr Thr Pro Gln Leu Arg Arg His Ala Lys Leu Lys Pro Pro 
            260                 265                 270         


Arg Thr Pro Pro Pro Pro Ser Arg Lys Val Phe Gln Leu Leu Pro Ser 
        275                 280                 285             


Phe Pro Thr Leu Thr Arg Ser Lys Ser His Glu Ser Gln Leu Gly Asn 
    290                 295                 300                 


Arg Ile Asp Asp Val Thr Pro Met Lys Phe Glu Leu Pro His Gly Ser 
305                 310                 315                 320 


Pro Gln Leu Val Arg Arg Asp Ile Gly Leu Ser Val Thr His Arg Phe 
                325                 330                 335     


Ser Thr Lys Ser Trp Leu Ser Gln Val Cys Asn Val Cys Gln Lys Ser 
            340                 345                 350         


Met Ile Phe Gly Val Lys Cys Lys His Cys Arg Leu Lys Cys His Asn 
        355                 360                 365             


Lys Cys Thr Lys Glu Ala Pro Ala Cys Arg Ile Thr Phe Leu Pro Leu 
    370                 375                 380                 


Ala Arg Leu Arg Arg Thr Glu Ser Val Pro Ser Asp Ile Asn Asn Pro 
385                 390                 395                 400 


Val Asp Arg Ala Ala Glu Pro His Phe Gly Thr Leu Pro Lys Ala Leu 
                405                 410                 415     


Thr Lys Lys Glu His Pro Pro Ala Met Asn Leu Asp Ser Ser Ser Asn 
            420                 425                 430         


Pro Ser Ser Thr Thr Ser Ser Thr Pro Ser Ser Pro Ala Pro Phe Leu 
        435                 440                 445             


Thr Ser Ser Asn Pro Ser Ser Ala Thr Thr Pro Pro Asn Pro Ser Pro 
    450                 455                 460                 


Gly Gln Arg Asp Ser Arg Phe Ser Phe Pro Asp Ile Ser Ala Cys Ser 
465                 470                 475                 480 


Gln Ala Ala Pro Leu Ser Ser Thr Ala Asp Ser Thr Arg Leu Asp Asp 
                485                 490                 495     


Gln Pro Lys Thr Asp Val Leu Gly Val His Glu Ala Glu Ala Glu Glu 
            500                 505                 510         


Pro Glu Ala Gly Lys Ser Glu Ala Glu Asp Asp Glu Glu Asp Glu Val 
        515                 520                 525             


Asp Asp Leu Pro Ser Ser Arg Arg Pro Trp Arg Gly Pro Ile Ser Arg 
    530                 535                 540                 


Lys Ala Ser Gln Thr Ser Val Tyr Leu Gln Glu Trp Asp Ile Pro Phe 
545                 550                 555                 560 


Glu Gln Val Glu Leu Gly Glu Pro Ile Gly Gln Gly Arg Trp Gly Arg 
                565                 570                 575     


Val His Arg Gly Arg Trp His Gly Glu Val Ala Ile Arg Leu Leu Glu 
            580                 585                 590         


Met Asp Gly His Asn Gln Asp His Leu Lys Leu Phe Lys Lys Glu Val 
        595                 600                 605             


Met Asn Tyr Arg Gln Thr Arg His Glu Asn Val Val Leu Phe Met Gly 
    610                 615                 620                 


Ala Cys Met Asn Pro Pro His Leu Ala Ile Ile Thr Ser Phe Cys Lys 
625                 630                 635                 640 


Gly Arg Thr Leu His Ser Phe Val Arg Asp Pro Lys Thr Ser Leu Asp 
                645                 650                 655     


Ile Asn Lys Thr Arg Gln Ile Ala Gln Glu Ile Ile Lys Gly Met Gly 
            660                 665                 670         


Tyr Leu His Ala Lys Gly Ile Val His Lys Asp Leu Lys Ser Lys Asn 
        675                 680                 685             


Val Phe Tyr Asp Asn Gly Lys Val Val Ile Thr Asp Phe Gly Leu Phe 
    690                 695                 700                 


Gly Ile Ser Gly Val Val Arg Glu Glu Arg Arg Glu Asn Gln Leu Lys 
705                 710                 715                 720 


Leu Ser His Asp Trp Leu Cys Tyr Leu Ala Pro Glu Ile Val Arg Glu 
                725                 730                 735     


Met Ile Pro Gly Arg Asp Glu Asp Gln Leu Pro Phe Ser Lys Ala Ala 
            740                 745                 750         


Asp Val Tyr Ala Phe Gly Thr Val Trp Tyr Glu Leu Gln Ala Arg Asp 
        755                 760                 765             


Trp Pro Phe Lys His Gln Pro Ala Glu Ala Leu Ile Trp Gln Ile Gly 
    770                 775                 780                 


Ser Gly Glu Gly Val Arg Arg Val Leu Ala Ser Val Ser Leu Gly Lys 
785                 790                 795                 800 


Glu Val Gly Glu Ile Leu Ser Ala Cys Trp Ala Phe Asp Leu Gln Glu 
                805                 810                 815     


Arg Pro Ser Phe Ser Leu Leu Met Asp Met Leu Glu Arg Leu Pro Lys 
            820                 825                 830         


Leu Asn Arg Arg Leu Ser His Pro Gly His Phe Trp Lys Ser Ala Asp 
        835                 840                 845             


Ile Asn Ser Ser Lys Val Met Pro Arg Phe Glu Arg Phe Gly Leu Gly 
    850                 855                 860                 


Thr Leu Glu Ser Gly Asn Pro Lys Met 
865                 870             


<210>  7
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


