                               SEQUENCE LISTING

<110> SORRENTO THERAPEUTICS, INC.
 
<120> ONCOLYTIC VIRUSES EXPRESSING IMMUNOMODULATORY FUSION PROTEINS

<130> 087735.0140

<140>
<141>

<150> 63/044,818
<151> 2020-06-26

<160> 68    

<170> PatentIn version 3.5

<210> 1
<211> 687
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
gagagcaagt acggcccccc ctgccccccc tgccccgccc ccgagttcct gggcggcccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg cacccccgag      120

gtgacctgcg tggtggtgga cgtgagccag gaggaccccg aggtgcagtt caactggtac      180

gtggacggcg tggaggtgca caacgccaag accaagcccc gcgaggagca gttcaacagc      240

acctaccgcg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      300

tacaagtgca aggtgagcaa caagggcctg cccagcagca tcgagaagac catcagcaag      360

gccaagggcc agccccgcga gccccaggtg tacaccctgc cccccagcca ggaggagatg      420

accaagaacc aggtgagcct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccccgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cgcctgaccg tggacaagag ccgctggcag      600

gagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgagcct gggcaag                                          687


<210> 2
<211> 229
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 3
<211> 229
<212> PRT
<213> Homo sapiens

<400> 3
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 4
<211> 696
<212> DNA
<213> Homo sapiens

<400> 4
gaaccaaagt cctctgataa aacacatact tgcccacctt gtcctgcacc agagctgctg       60

ggaggtccaa gcgtgttcct gtttcctccc aagccaaaag atactcttat gattagccga      120

acaccagagg tgacgtgcgt ggtggtcgac gtatcacacg aggaccctga agtgaagttt      180

aattggtacg tagacggggt tgaggtgcat aacgcgaaga ccaaacctag agaggagcag      240

tataattcaa cctaccgggt cgtttctgtc ctcacagtcc tccaccaaga ttggttgaac      300

ggaaaagaat ataagtgtaa agtgtctaac aaggctcttc ccgcgcctat agagaaaacg      360

atcagcaaag cgaaggggca accaagggaa ccgcaagtct acactcttcc accgtcacgg      420

gatgagctga ctaagaatca agtgtcactt acttgccttg taaaaggatt ctacccatca      480

gacatcgcgg tcgagtggga atctaacggt caaccggaga acaattataa aaccactcct      540

cccgttcttg actccgacgg ttcatttttc ctctattcca aactgacggt tgataagtct      600

cgatggcaac aaggcaatgt gtttagttgt tctgtcatgc acgaagcact gcacaaccat      660

tatacacaaa agtcactttc tctcagtccc ggaaag                                696


<210> 5
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 6
<211> 408
<212> DNA
<213> Homo sapiens

<400> 6
attcctcctc acgtccaaaa gtcagtaaat aatgatatga tagtcactga taataatggt       60

gctgtaaagt tcccacagct ttgcaagttt tgcgatgtca ggttttctac ctgcgataat      120

cagaagagct gcatgagcaa ttgctctatt acatccatct gtgaaaagcc gcaggaggta      180

tgtgtagcag tatggagaaa gaacgatgaa aacattacac tcgaaaccgt ttgccacgac      240

ccaaaacttc catatcacga ttttatactc gaagatgcgg caagtcccaa atgcataatg      300

aaagagaaga aaaaaccagg cgaaacgttt tttatgtgta gttgcagtag cgatgagtgc      360

aacgataata taatcttctc agaagagtat aacacttcta acccagac                   408


<210> 7
<211> 136
<212> PRT
<213> Homo sapiens

<400> 7
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210> 8
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Arg Leu Thr Thr Asn 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Gly Gly Gly Pro Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Tyr Gly Thr Lys Asp Ala Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 9
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Val Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Gly Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln His Phe Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asn Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Asn Leu 
                85                  90                  95      


Ser Ala Tyr Val Phe Ala Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 10
<211> 783
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
atggagtgga gctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

gtgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcgccagcgt gaaggtgagc      120

tgcaaggcca gcggcttccg cctgaccacc aacggcatca gctgggtgcg ccaggccccc      180

ggccagggcc tggagtggat gggctggatc agcgccggcg gcggccccac caactacgcc      240

cagaagctgc agggccgcgt gaccatgacc accgacacca gcaccagcac cgcctacatg      300

gagctgcgca gcctgcgcag cgacgacacc gccgtgtact actgcgccaa gggcctgtac      360

ggcaccaagg acgcctgggg ccagggcacc ctggtgaccg tgagcagcgg cggcggcggc      420

agcggcggcg gcggcagcgg cggcggcggc agccagagcg tgctgaccca gccccccagc      480

gtgagcgagg tgcccggcca gcgcgtgacc atcagctgca gcggcggcgg cagcaacatc      540

ggcagcaacg ccgtgaactg gtaccagcac ttccccggca aggcccccaa gctgctgatc      600

tactacaacg acctgctgcc cagcggcgtg agcgaccgct tcagcgccag caagagcggc      660

accagcgcca gcctggccat cagcggcctg cgcagcgagg acgaggccga ctactactgc      720

gccgcctggg acgacaacct gagcgcctac gtgttcgcca ccggcaccaa ggtgaccgtg      780

ctg                                                                    783


<210> 11
<211> 261
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Arg Leu 
        35                  40                  45              


Thr Thr Asn Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Ser Ala Gly Gly Gly Pro Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Leu Tyr Gly Thr Lys Asp Ala Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
145                 150                 155                 160 


Val Ser Glu Val Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Gly 
                165                 170                 175     


Gly Ser Asn Ile Gly Ser Asn Ala Val Asn Trp Tyr Gln His Phe Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Asn Asp Leu Leu Pro Ser 
        195                 200                 205             


Gly Val Ser Asp Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser 
    210                 215                 220                 


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Trp Asp Asp Asn Leu Ser Ala Tyr Val Phe Ala Thr Gly Thr 
                245                 250                 255     


Lys Val Thr Val Leu 
            260     


<210> 12
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asp Asn 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Ile Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Gln Ala Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 13
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Leu Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Ala Asp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 14
<211> 792
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
atggagtggt cttgggtatt cctctttttt cttagcgtca ccacaggtgt tcactcccaa       60

gttcaacttg tgcaaagcgg ctccgagttg aagaaacctg gggcaagcgt gaagatctca      120

tgcaaagctt ccggctatat attttcagac aatggggtta actgggtacg ccaggccccg      180

ggtcagggac tggagtggat gggttggatc aatacaaaga ttggtaatcc tacatacgca      240

cagggattta cggggcgatt cgtattctca ctcgatacct ctataagcac aacctacctt      300

cagataagct ccttgcaagc aggtgatacc gctgtgtact actgcgcacg ggaacacgac      360

tattattacg gtatggatgt gtggggtcaa gggaccacag tgactgttag cagcggcggc      420

ggaggatccg gaggcggagg aagtggtggc gggggttcac aaagcgctct cacacaacca      480

ccaagtgcca gtgggtcccc aggacaaagt gttacaatct cctgcactgg gacctcatct      540

gatgtggggg ggtacaatta tgtaagctgg taccaacatc atccaggaaa ggctccaaaa      600

ttgatgatct atgaagtgtc taagcggcct tcaggagttc cggacaggtt ctctgggtca      660

aaaagtgcca tcacggcgtc acttacgatt tctggcctcc ttaccgaaga tgaagccgac      720

tactactgct cagcatggga cgattccctg aacgcggatg tattcggggg tggcaccaaa      780

gttacggtcc tg                                                          792


<210> 15
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
        35                  40                  45              


Ser Asp Asn Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr Lys Ile Gly Asn Pro Thr Tyr Ala 
65                  70                  75                  80  


Gln Gly Phe Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Thr Tyr Leu Gln Ile Ser Ser Leu Gln Ala Gly Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu His Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr 
                165                 170                 175     


Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln 
            180                 185                 190         


His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys 
        195                 200                 205             


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Ala Ile 
    210                 215                 220                 


Thr Ala Ser Leu Thr Ile Ser Gly Leu Leu Thr Glu Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu Asn Ala Asp Val Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Val Thr Val Leu 
            260                 


<210> 16
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 17
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr 
            100                 105                 110         


Ser Glu Asn Leu Tyr Phe Gln 
        115                 


<210> 18
<211> 795
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
atggagtgga gttgggtctt tctcttcttc ctgtctgtaa cgactggcgt gcattcacag       60

gtgcaacttg tacagagcgg cgttgaagtg aaaaaacccg gcgcaagtgt gaaagtcagc      120

tgcaaagcgt caggctacac gttcacgaat tattacatgt attgggttag gcaggcacct      180

ggacaggggc tggagtggat gggtggcata aacccttcta atggcggaac caactttaac      240

gagaagttta agaaccgagt aacactcacg actgatagca gtacgaccac ggcgtacatg      300

gaacttaaaa gcctccaatt tgacgataca gctgtgtact attgcgccag acgcgattac      360

cggttcgaca tgggcttcga ctattggggt cagggaacga cggtcacagt cagttctggg      420

ggaggaggta gtggaggggg agggagtggg ggcggaggta gtgagatagt tttgacgcag      480

tccccggcaa ctctgtccct gtcacctggt gaaagggcca ccctgagctg ccgggcgtca      540

aaaggggtat ccacgagcgg atattcctat ttgcattggt accagcaaaa acccggtcag      600

gctccgaggc ttttgattta cttggcgtcc tatctggaaa gcggagttcc cgctcgcttt      660

tcaggctccg gtagcggtac agattttact ctcacgattt cttccctgga gccggaagac      720

tttgcggtat attattgtca gcatagtcgc gacctccctc ttacattcgg aggaggtacg      780

aaggtcgaaa ttaaa                                                       795


<210> 19
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu 
        195                 200                 205             


Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Asp Leu Pro Leu Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys 
            260                 265 


<210> 20
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asn Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Met Lys Pro Ser Gly Gly Ser Thr Ser Ile Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Phe Pro His Ile Phe Gly Asn Tyr Tyr Gly Met Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 21
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Asp Ile Val Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 22
<211> 795
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
atggagtgga gctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

gtgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcgccagcgt gaaggtgagc      120

tgcaagacca gcggcaacac cttcaccaac tacgccctgc actgggtgcg ccaggccccc      180

ggccagggcc tggagtggat gggcggcatg aagcccagcg gcggcagcac cagcatcgcc      240

cagaagttcc agggccgcgt gaccatgacc cgcgacaaga gcaccagcac cgtgtacatg      300

gagctgagca gcctgaccag cgaggacacc gccgtgtact actgcgcccg cgacctgttc      360

ccccacatct tcggcaacta ctacggcatg gacatctggg gccagggcac caccgtgacc      420

gtgagcagcg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg cagcgacatc      480

gtgatgaccc agagcccccc cagcctgagc gccagcgtgg gcgaccgcgt gaccatcacc      540

tgccgcgcca gccagagcat cagcagctac ctgaactggt accagcagaa gcccggcaag      600

gcccccaagc tgctgatcta cgccaccagc agcctgcagt acggcgtgcc cagccgcttc      660

agcggcagcg gcagcggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      720

ttcgccacct actactgcca gggcagctac agcaccccct acaccttcgg ccagggcacc      780

aaggtggaga tcaag                                                       795


<210> 23
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asn Thr Phe 
        35                  40                  45              


Thr Asn Tyr Ala Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Met Lys Pro Ser Gly Gly Ser Thr Ser Ile Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Leu Phe Pro His Ile Phe Gly Asn Tyr Tyr 
        115                 120                 125             


Gly Met Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        195                 200                 205             


Thr Ser Ser Leu Gln Tyr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Ser Thr Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Val Glu Ile Lys 
            260                 265 


<210> 24
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Tyr Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ile Val Ala Thr Ile Thr Pro Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 25
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Thr Ile Ala Cys Gly Gly Glu Asn Ile Gly Arg Lys Thr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Arg Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 26
<211> 789
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
atggagtgga gctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

atgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcagcagcgt gaaggtgagc      120

tgcaaggcca gcggcggcac cttcagcagc tacgcctaca gctgggtgcg ccaggccccc      180

ggccagggcc tggagtggat gggcggcatc atccccagct tcggcaccgc caactacgcc      240

cagaagttcc agggccgcgt gaccatcacc gccgacgaga gcaccagcac cgcctacatg      300

gagctgagca gcctgcgcag cgaggacacc gccgtgtact actgcgcccg cggccccatc      360

gtggccacca tcacccccct ggactactgg ggccagggca ccctggtgac cgtgagcagc      420

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcagcta cgtgctgacc      480

cagcccccca gcgtgagcgt ggcccccggc aagaccgcca ccatcgcctg cggcggcgag      540

aacatcggcc gcaagaccgt gcactggtac cagcagaagc ccggccaggc ccccgtgctg      600

gtgatctact acgacagcga ccgccccagc ggcatccccg agcgcttcag cggcagcaac      660

agcggcaaca ccgccaccct gaccatcagc cgcgtggagg ccggcgacga ggccgactac      720

tactgcctgg tgtgggacag cagcagcgac caccgcatct tcggcggcgg caccaagctg      780

accgtgctg                                                              789


<210> 27
<211> 263
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Tyr Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Pro Ile Val Ala Thr Ile Thr Pro Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Ala 
                165                 170                 175     


Cys Gly Gly Glu Asn Ile Gly Arg Lys Thr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr Asp Ser Asp Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Leu Val Trp Asp Ser Ser Ser Asp His Arg Ile Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Thr Val Leu 
            260             


<210> 28
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 29
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 30
<211> 792
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 30
atggaatggt cctgggtctt ccttttcttc ctctctgtta ccactggcgt tcacagccaa       60

tcagcactta cgcaacctgc tagcgttagt ggtagtccag gtcagagcat cacaatttca      120

tgtactggga cctccagcga tgtaggagga tacaactacg tgtcatggta tcagcagcac      180

cccggcaagg cccctaagct tatgatctac gacgtctcaa acaggcccag tggtgttagt      240

aacaggttta gcggatcaaa atctggaaat acagcgagtc tcactatttc cgggttgcaa      300

gctgaggatg aagctgacta ttattgttct tcatacacat cttcatcaac aagagtattt      360

gggacaggaa caaaagtgac agtcttgggt ggtggaggca gtgggggagg aggtagtggc      420

ggcggtgggt cagaagtcca actcttggaa agcggcgggg gcctcgtaca acctggtggc      480

agtctgagac tgtcatgcgc ggcaagcgga ttcactttct catcttatat aatgatgtgg      540

gttagacaag cgccagggaa aggcttggaa tgggtaagtt caatctaccc gtctggcggg      600

attacgttct acgctgatac ggtgaaaggg aggttcacga tttctcgaga caactccaag      660

aatacgctgt atcttcagat gaactctctc cgagccgaag ataccgcagt atactactgc      720

gcacgcatta aactgggcac cgttaccaca gttgattact ggggccaggg tacgctcgtg      780

acggtctcta gc                                                          792


<210> 31
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser 
            20                  25                  30          


Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val 
        35                  40                  45              


Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
                85                  90                  95      


Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr 
            100                 105                 110         


Thr Ser Ser Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                165                 170                 175     


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser 
            260                 


<210> 32
<211> 525
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 32
aaggatctgc gatcgctccg gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc       60

cgagaagttg gggggagggg tcggcaattg aacgggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagctgaag cttcgagggg ctcgcatctc tccttcacgc gcccgccgcc ctacctgagg      300

ccgccatcca cgccggttga gtcgcgttct gccgcctccc gcctgtggtg cctcctgaac      360

tgcgtccgcc gtctaggtaa gtttaaagct caggtcgaga ccgggccttt gtccggcgct      420

cccttggagc ctacctagac tcagccggct ctccacgctt tgcctgaccc tgcttgctca      480

actctacgtc tttgtttcgt tttctgttct gcgccgttac agatc                      525


<210> 33
<211> 603
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cytomegalovirus sequence"

<400> 33
aagcttggga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgactctact      600

aga                                                                    603


<210> 34
<211> 19
<212> PRT
<213> Mus musculus

<400> 34
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 35
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Asp 
            20  


<210> 36
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


<210> 37
<211> 225
<212> DNA
<213> Bos taurus

<400> 37
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210> 38
<211> 237
<212> DNA
<213> Simian virus 40

<400> 38
tagataactg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa       60

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt      120

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa      180

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatctta         237


<210> 39
<211> 1923
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 39
atggagtgga gctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

gtgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcgccagcgt gaaggtgagc      120

tgcaaggcca gcggcttccg cctgaccacc aacggcatca gctgggtgcg ccaggccccc      180

ggccagggcc tggagtggat gggctggatc agcgccggcg gcggccccac caactacgcc      240

cagaagctgc agggccgcgt gaccatgacc accgacacca gcaccagcac cgcctacatg      300

gagctgcgca gcctgcgcag cgacgacacc gccgtgtact actgcgccaa gggcctgtac      360

ggcaccaagg acgcctgggg ccagggcacc ctggtgaccg tgagcagcgg cggcggcggc      420

agcggcggcg gcggcagcgg cggcggcggc agccagagcg tgctgaccca gccccccagc      480

gtgagcgagg tgcccggcca gcgcgtgacc atcagctgca gcggcggcgg cagcaacatc      540

ggcagcaacg ccgtgaactg gtaccagcac ttccccggca aggcccccaa gctgctgatc      600

tactacaacg acctgctgcc cagcggcgtg agcgaccgct tcagcgccag caagagcggc      660

accagcgcca gcctggccat cagcggcctg cgcagcgagg acgaggccga ctactactgc      720

gccgcctggg acgacaacct gagcgcctac gtgttcgcca ccggcaccaa ggtgaccgtg      780

ctggagagca agtacggccc cccctgcccc ccctgccccg cccccgagtt cctgggcggc      840

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag ccgcaccccc      900

gaggtgacct gcgtggtggt ggacgtgagc caggaggacc ccgaggtgca gttcaactgg      960

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgcgagga gcagttcaac     1020

agcacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1080

gagtacaagt gcaaggtgag caacaagggc ctgcccagca gcatcgagaa gaccatcagc     1140

aaggccaagg gccagccccg cgagccccag gtgtacaccc tgccccccag ccaggaggag     1200

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc cagcgacatc     1260

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccccgtg     1320

ctggacagcg acggcagctt cttcctgtac agccgcctga ccgtggacaa gagccgctgg     1380

caggagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1440

cagaagagcc tgagcctgag cctgggcaag ggaggtggcg ggtcaggcgg aggtggtagt     1500

ggcggcggtg ggagtattcc tcctcacgtc caaaagtcag taaataatga tatgatagtc     1560

actgataata atggtgctgt aaagttccca cagctttgca agttttgcga tgtcaggttt     1620

tctacctgcg ataatcagaa gagctgcatg agcaattgct ctattacatc catctgtgaa     1680

aagccgcagg aggtatgtgt agcagtatgg agaaagaacg atgaaaacat tacactcgaa     1740

accgtttgcc acgacccaaa acttccatat cacgatttta tactcgaaga tgcggcaagt     1800

cccaaatgca taatgaaaga gaagaaaaaa ccaggcgaaa cgttttttat gtgtagttgc     1860

agtagcgatg agtgcaacga taatataatc ttctcagaag agtataacac ttctaaccca     1920

gac                                                                   1923


<210> 40
<211> 641
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Arg Leu 
        35                  40                  45              


Thr Thr Asn Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Ser Ala Gly Gly Gly Pro Thr Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Leu Tyr Gly Thr Lys Asp Ala Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
145                 150                 155                 160 


Val Ser Glu Val Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Gly 
                165                 170                 175     


Gly Ser Asn Ile Gly Ser Asn Ala Val Asn Trp Tyr Gln His Phe Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Asn Asp Leu Leu Pro Ser 
        195                 200                 205             


Gly Val Ser Asp Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser 
    210                 215                 220                 


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Trp Asp Asp Asn Leu Ser Ala Tyr Val Phe Ala Thr Gly Thr 
                245                 250                 255     


Lys Val Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
385                 390                 395                 400 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
            500                 505                 510         


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
        515                 520                 525             


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
    530                 535                 540                 


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
545                 550                 555                 560 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
                565                 570                 575     


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
            580                 585                 590         


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
        595                 600                 605             


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
    610                 615                 620                 


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
625                 630                 635                 640 


Asp 
    


<210> 41
<211> 1932
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 41
atggagtggt cttgggtatt cctctttttt cttagcgtca ccacaggtgt tcactcccaa       60

gttcaacttg tgcaaagcgg ctccgagttg aagaaacctg gggcaagcgt gaagatctca      120

tgcaaagctt ccggctatat attttcagac aatggggtta actgggtacg ccaggccccg      180

ggtcagggac tggagtggat gggttggatc aatacaaaga ttggtaatcc tacatacgca      240

cagggattta cggggcgatt cgtattctca ctcgatacct ctataagcac aacctacctt      300

cagataagct ccttgcaagc aggtgatacc gctgtgtact actgcgcacg ggaacacgac      360

tattattacg gtatggatgt gtggggtcaa gggaccacag tgactgttag cagcggcggc      420

ggaggatccg gaggcggagg aagtggtggc gggggttcac aaagcgctct cacacaacca      480

ccaagtgcca gtgggtcccc aggacaaagt gttacaatct cctgcactgg gacctcatct      540

gatgtggggg ggtacaatta tgtaagctgg taccaacatc atccaggaaa ggctccaaaa      600

ttgatgatct atgaagtgtc taagcggcct tcaggagttc cggacaggtt ctctgggtca      660

aaaagtgcca tcacggcgtc acttacgatt tctggcctcc ttaccgaaga tgaagccgac      720

tactactgct cagcatggga cgattccctg aacgcggatg tattcggggg tggcaccaaa      780

gttacggtcc tggagagcaa gtacggcccc ccctgccccc cctgccccgc ccccgagttc      840

ctgggcggcc ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      900

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc aggaggaccc cgaggtgcag      960

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgcgaggag     1020

cagttcaaca gcacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1080

aacggcaagg agtacaagtg caaggtgagc aacaagggcc tgcccagcag catcgagaag     1140

accatcagca aggccaaggg ccagccccgc gagccccagg tgtacaccct gccccccagc     1200

caggaggaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1260

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1320

ccccccgtgc tggacagcga cggcagcttc ttcctgtaca gccgcctgac cgtggacaag     1380

agccgctggc aggagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1440

cactacaccc agaagagcct gagcctgagc ctgggcaagg gaggtggcgg gtcaggcgga     1500

ggtggtagtg gcggcggtgg gagtattcct cctcacgtcc aaaagtcagt aaataatgat     1560

atgatagtca ctgataataa tggtgctgta aagttcccac agctttgcaa gttttgcgat     1620

gtcaggtttt ctacctgcga taatcagaag agctgcatga gcaattgctc tattacatcc     1680

atctgtgaaa agccgcagga ggtatgtgta gcagtatgga gaaagaacga tgaaaacatt     1740

acactcgaaa ccgtttgcca cgacccaaaa cttccatatc acgattttat actcgaagat     1800

gcggcaagtc ccaaatgcat aatgaaagag aagaaaaaac caggcgaaac gttttttatg     1860

tgtagttgca gtagcgatga gtgcaacgat aatataatct tctcagaaga gtataacact     1920

tctaacccag ac                                                         1932


<210> 42
<211> 644
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
        35                  40                  45              


Ser Asp Asn Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr Lys Ile Gly Asn Pro Thr Tyr Ala 
65                  70                  75                  80  


Gln Gly Phe Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Thr Tyr Leu Gln Ile Ser Ser Leu Gln Ala Gly Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu His Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr 
                165                 170                 175     


Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln 
            180                 185                 190         


His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys 
        195                 200                 205             


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Ala Ile 
    210                 215                 220                 


Thr Ala Ser Leu Thr Ile Ser Gly Leu Leu Thr Glu Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu Asn Ala Asp Val Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Val Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His 
            500                 505                 510         


Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly 
        515                 520                 525             


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
    530                 535                 540                 


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
545                 550                 555                 560 


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
                565                 570                 575     


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
            580                 585                 590         


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
        595                 600                 605             


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
    610                 615                 620                 


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
625                 630                 635                 640 


Ser Asn Pro Asp 
                


<210> 43
<211> 1935
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 43
atggagtgga gttgggtctt tctcttcttc ctgtctgtaa cgactggcgt gcattcacag       60

gtgcaacttg tacagagcgg cgttgaagtg aaaaaacccg gcgcaagtgt gaaagtcagc      120

tgcaaagcgt caggctacac gttcacgaat tattacatgt attgggttag gcaggcacct      180

ggacaggggc tggagtggat gggtggcata aacccttcta atggcggaac caactttaac      240

gagaagttta agaaccgagt aacactcacg actgatagca gtacgaccac ggcgtacatg      300

gaacttaaaa gcctccaatt tgacgataca gctgtgtact attgcgccag acgcgattac      360

cggttcgaca tgggcttcga ctattggggt cagggaacga cggtcacagt cagttctggg      420

ggaggaggta gtggaggggg agggagtggg ggcggaggta gtgagatagt tttgacgcag      480

tccccggcaa ctctgtccct gtcacctggt gaaagggcca ccctgagctg ccgggcgtca      540

aaaggggtat ccacgagcgg atattcctat ttgcattggt accagcaaaa acccggtcag      600

gctccgaggc ttttgattta cttggcgtcc tatctggaaa gcggagttcc cgctcgcttt      660

tcaggctccg gtagcggtac agattttact ctcacgattt cttccctgga gccggaagac      720

tttgcggtat attattgtca gcatagtcgc gacctccctc ttacattcgg aggaggtacg      780

aaggtcgaaa ttaaagagag caagtacggc cccccctgcc ccccctgccc cgcccccgag      840

ttcctgggcg gccccagcgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      900

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccaggagga ccccgaggtg      960

cagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gccccgcgag     1020

gagcagttca acagcaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1080

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg gcctgcccag cagcatcgag     1140

aagaccatca gcaaggccaa gggccagccc cgcgagcccc aggtgtacac cctgcccccc     1200

agccaggagg agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1260

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1320

accccccccg tgctggacag cgacggcagc ttcttcctgt acagccgcct gaccgtggac     1380

aagagccgct ggcaggaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1440

aaccactaca cccagaagag cctgagcctg agcctgggca agggaggtgg cgggtcaggc     1500

ggaggtggta gtggcggcgg tgggagtatt cctcctcacg tccaaaagtc agtaaataat     1560

gatatgatag tcactgataa taatggtgct gtaaagttcc cacagctttg caagttttgc     1620

gatgtcaggt tttctacctg cgataatcag aagagctgca tgagcaattg ctctattaca     1680

tccatctgtg aaaagccgca ggaggtatgt gtagcagtat ggagaaagaa cgatgaaaac     1740

attacactcg aaaccgtttg ccacgaccca aaacttccat atcacgattt tatactcgaa     1800

gatgcggcaa gtcccaaatg cataatgaaa gagaagaaaa aaccaggcga aacgtttttt     1860

atgtgtagtt gcagtagcga tgagtgcaac gataatataa tcttctcaga agagtataac     1920

acttctaacc cagac                                                      1935


<210> 44
<211> 645
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu 
        195                 200                 205             


Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Asp Leu Pro Leu Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
305                 310                 315                 320 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro 
            500                 505                 510         


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
        515                 520                 525             


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
    530                 535                 540                 


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
545                 550                 555                 560 


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
                565                 570                 575     


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
            580                 585                 590         


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
        595                 600                 605             


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
    610                 615                 620                 


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
625                 630                 635                 640 


Thr Ser Asn Pro Asp 
                645 


<210> 45
<211> 1935
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 45
atggagtgga gctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

gtgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcgccagcgt gaaggtgagc      120

tgcaagacca gcggcaacac cttcaccaac tacgccctgc actgggtgcg ccaggccccc      180

ggccagggcc tggagtggat gggcggcatg aagcccagcg gcggcagcac cagcatcgcc      240

cagaagttcc agggccgcgt gaccatgacc cgcgacaaga gcaccagcac cgtgtacatg      300

gagctgagca gcctgaccag cgaggacacc gccgtgtact actgcgcccg cgacctgttc      360

ccccacatct tcggcaacta ctacggcatg gacatctggg gccagggcac caccgtgacc      420

gtgagcagcg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg cagcgacatc      480

gtgatgaccc agagcccccc cagcctgagc gccagcgtgg gcgaccgcgt gaccatcacc      540

tgccgcgcca gccagagcat cagcagctac ctgaactggt accagcagaa gcccggcaag      600

gcccccaagc tgctgatcta cgccaccagc agcctgcagt acggcgtgcc cagccgcttc      660

agcggcagcg gcagcggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      720

ttcgccacct actactgcca gggcagctac agcaccccct acaccttcgg ccagggcacc      780

aaggtggaga tcaaggagag caagtacggc cccccctgcc ccccctgccc cgcccccgag      840

ttcctgggcg gccccagcgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      900

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccaggagga ccccgaggtg      960

cagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gccccgcgag     1020

gagcagttca acagcaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1080

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg gcctgcccag cagcatcgag     1140

aagaccatca gcaaggccaa gggccagccc cgcgagcccc aggtgtacac cctgcccccc     1200

agccaggagg agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1260

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1320

accccccccg tgctggacag cgacggcagc ttcttcctgt acagccgcct gaccgtggac     1380

aagagccgct ggcaggaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1440

aaccactaca cccagaagag cctgagcctg agcctgggca agggaggtgg cgggtcaggc     1500

ggaggtggta gtggcggcgg tgggagtatt cctcctcacg tccaaaagtc agtaaataat     1560

gatatgatag tcactgataa taatggtgct gtaaagttcc cacagctttg caagttttgc     1620

gatgtcaggt tttctacctg cgataatcag aagagctgca tgagcaattg ctctattaca     1680

tccatctgtg aaaagccgca ggaggtatgt gtagcagtat ggagaaagaa cgatgaaaac     1740

attacactcg aaaccgtttg ccacgaccca aaacttccat atcacgattt tatactcgaa     1800

gatgcggcaa gtcccaaatg cataatgaaa gagaagaaaa aaccaggcga aacgtttttt     1860

atgtgtagtt gcagtagcga tgagtgcaac gataatataa tcttctcaga agagtataac     1920

acttctaacc cagac                                                      1935


<210> 46
<211> 645
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asn Thr Phe 
        35                  40                  45              


Thr Asn Tyr Ala Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Met Lys Pro Ser Gly Gly Ser Thr Ser Ile Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Leu Phe Pro His Ile Phe Gly Asn Tyr Tyr 
        115                 120                 125             


Gly Met Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        195                 200                 205             


Thr Ser Ser Leu Gln Tyr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Ser Thr Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
305                 310                 315                 320 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro 
            500                 505                 510         


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
        515                 520                 525             


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
    530                 535                 540                 


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
545                 550                 555                 560 


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
                565                 570                 575     


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
            580                 585                 590         


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
        595                 600                 605             


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
    610                 615                 620                 


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
625                 630                 635                 640 


Thr Ser Asn Pro Asp 
                645 


<210> 47
<211> 1929
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 47
atggagtgga gctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

atgcagctgg tgcagagcgg cgccgaggtg aagaagcccg gcagcagcgt gaaggtgagc      120

tgcaaggcca gcggcggcac cttcagcagc tacgcctaca gctgggtgcg ccaggccccc      180

ggccagggcc tggagtggat gggcggcatc atccccagct tcggcaccgc caactacgcc      240

cagaagttcc agggccgcgt gaccatcacc gccgacgaga gcaccagcac cgcctacatg      300

gagctgagca gcctgcgcag cgaggacacc gccgtgtact actgcgcccg cggccccatc      360

gtggccacca tcacccccct ggactactgg ggccagggca ccctggtgac cgtgagcagc      420

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcagcta cgtgctgacc      480

cagcccccca gcgtgagcgt ggcccccggc aagaccgcca ccatcgcctg cggcggcgag      540

aacatcggcc gcaagaccgt gcactggtac cagcagaagc ccggccaggc ccccgtgctg      600

gtgatctact acgacagcga ccgccccagc ggcatccccg agcgcttcag cggcagcaac      660

agcggcaaca ccgccaccct gaccatcagc cgcgtggagg ccggcgacga ggccgactac      720

tactgcctgg tgtgggacag cagcagcgac caccgcatct tcggcggcgg caccaagctg      780

accgtgctgg agagcaagta cggccccccc tgccccccct gccccgcccc cgagttcctg      840

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc      900

acccccgagg tgacctgcgt ggtggtggac gtgagccagg aggaccccga ggtgcagttc      960

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag     1020

ttcaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1080

ggcaaggagt acaagtgcaa ggtgagcaac aagggcctgc ccagcagcat cgagaagacc     1140

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccag     1200

gaggagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc     1260

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1320

cccgtgctgg acagcgacgg cagcttcttc ctgtacagcc gcctgaccgt ggacaagagc     1380

cgctggcagg agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1440

tacacccaga agagcctgag cctgagcctg ggcaagggag gtggcgggtc aggcggaggt     1500

ggtagtggcg gcggtgggag tattcctcct cacgtccaaa agtcagtaaa taatgatatg     1560

atagtcactg ataataatgg tgctgtaaag ttcccacagc tttgcaagtt ttgcgatgtc     1620

aggttttcta cctgcgataa tcagaagagc tgcatgagca attgctctat tacatccatc     1680

tgtgaaaagc cgcaggaggt atgtgtagca gtatggagaa agaacgatga aaacattaca     1740

ctcgaaaccg tttgccacga cccaaaactt ccatatcacg attttatact cgaagatgcg     1800

gcaagtccca aatgcataat gaaagagaag aaaaaaccag gcgaaacgtt ttttatgtgt     1860

agttgcagta gcgatgagtg caacgataat ataatcttct cagaagagta taacacttct     1920

aacccagac                                                             1929


<210> 48
<211> 643
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Tyr Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Pro Ile Val Ala Thr Ile Thr Pro Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Ala 
                165                 170                 175     


Cys Gly Gly Glu Asn Ile Gly Arg Lys Thr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr Asp Ser Asp Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Leu Val Trp Asp Ser Ser Ser Asp His Arg Ile Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
385                 390                 395                 400 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val 
            500                 505                 510         


Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala 
        515                 520                 525             


Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr 
    530                 535                 540                 


Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile 
545                 550                 555                 560 


Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp 
                565                 570                 575     


Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr 
            580                 585                 590         


His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys 
        595                 600                 605             


Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser 
    610                 615                 620                 


Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser 
625                 630                 635                 640 


Asn Pro Asp 
            


<210> 49
<211> 1932
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 49
atggaatggt cctgggtctt ccttttcttc ctctctgtta ccactggcgt tcacagccaa       60

tcagcactta cgcaacctgc tagcgttagt ggtagtccag gtcagagcat cacaatttca      120

tgtactggga cctccagcga tgtaggagga tacaactacg tgtcatggta tcagcagcac      180

cccggcaagg cccctaagct tatgatctac gacgtctcaa acaggcccag tggtgttagt      240

aacaggttta gcggatcaaa atctggaaat acagcgagtc tcactatttc cgggttgcaa      300

gctgaggatg aagctgacta ttattgttct tcatacacat cttcatcaac aagagtattt      360

gggacaggaa caaaagtgac agtcttgggt ggtggaggca gtgggggagg aggtagtggc      420

ggcggtgggt cagaagtcca actcttggaa agcggcgggg gcctcgtaca acctggtggc      480

agtctgagac tgtcatgcgc ggcaagcgga ttcactttct catcttatat aatgatgtgg      540

gttagacaag cgccagggaa aggcttggaa tgggtaagtt caatctaccc gtctggcggg      600

attacgttct acgctgatac ggtgaaaggg aggttcacga tttctcgaga caactccaag      660

aatacgctgt atcttcagat gaactctctc cgagccgaag ataccgcagt atactactgc      720

gcacgcatta aactgggcac cgttaccaca gttgattact ggggccaggg tacgctcgtg      780

acggtctcta gcgagagcaa gtacggcccc ccctgccccc cctgccccgc ccccgagttc      840

ctgggcggcc ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      900

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc aggaggaccc cgaggtgcag      960

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgcgaggag     1020

cagttcaaca gcacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1080

aacggcaagg agtacaagtg caaggtgagc aacaagggcc tgcccagcag catcgagaag     1140

accatcagca aggccaaggg ccagccccgc gagccccagg tgtacaccct gccccccagc     1200

caggaggaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1260

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1320

ccccccgtgc tggacagcga cggcagcttc ttcctgtaca gccgcctgac cgtggacaag     1380

agccgctggc aggagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1440

cactacaccc agaagagcct gagcctgagc ctgggcaagg gaggtggcgg gtcaggcgga     1500

ggtggtagtg gcggcggtgg gagtattcct cctcacgtcc aaaagtcagt aaataatgat     1560

atgatagtca ctgataataa tggtgctgta aagttcccac agctttgcaa gttttgcgat     1620

gtcaggtttt ctacctgcga taatcagaag agctgcatga gcaattgctc tattacatcc     1680

atctgtgaaa agccgcagga ggtatgtgta gcagtatgga gaaagaacga tgaaaacatt     1740

acactcgaaa ccgtttgcca cgacccaaaa cttccatatc acgattttat actcgaagat     1800

gcggcaagtc ccaaatgcat aatgaaagag aagaaaaaac caggcgaaac gttttttatg     1860

tgtagttgca gtagcgatga gtgcaacgat aatataatct tctcagaaga gtataacact     1920

tctaacccag ac                                                         1932


<210> 50
<211> 644
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser 
            20                  25                  30          


Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val 
        35                  40                  45              


Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
                85                  90                  95      


Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr 
            100                 105                 110         


Thr Ser Ser Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                165                 170                 175     


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His 
            500                 505                 510         


Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly 
        515                 520                 525             


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
    530                 535                 540                 


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
545                 550                 555                 560 


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
                565                 570                 575     


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
            580                 585                 590         


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
        595                 600                 605             


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
    610                 615                 620                 


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
625                 630                 635                 640 


Ser Asn Pro Asp 
                


<210> 51
<211> 1608
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 51
atgtgtcatc agcagctggt gatttcttgg ttctctttag tgtttctggc cagccctctg       60

gtcgccatct gggagctcaa gaaggatgtg tacgtcgtgg agctcgattg gtaccccgat      120

gcccccggtg aaatggtcgt gctcacttgt gacacccccg aagaggatgg catcacatgg      180

actttagatc agtccagcga ggtgctggga agcggcaaga ctttaacaat ccaagttaag      240

gagttcggag acgccggaca gtatacttgt cacaagggcg gcgaagtgct gagccattct      300

ttactgttat tacataagaa ggaggacggc atctggagca ccgacatcct caaggaccag      360

aaggagccca aaaacaagac cttcttacgt tgtgaggcca aaaactattc cggcagattt      420

acttgttggt ggctgacaac catcagcaca gatttaacct ttagcgtgaa gagctctcgt      480

ggaagcagcg accctcaagg tgtgacatgt ggagccgcca ccctcagcgc cgaaagggtt      540

cgtggcgata ataaagaata cgagtatagc gtggagtgcc aagaagacag cgcttgcccc      600

gctgccgaag aatctttacc catcgaggtg atggtcgacg ccgtccacaa gctgaagtac      660

gaaaactaca catcctcctt cttcatcaga gatatcatca agcccgatcc ccccaagaat      720

ctgcagctga aacctttaaa gaattctcgt caagttgaag tgagctggga gtatcccgac      780

acttggtcca ccccccactc ctacttcagc ctcaccttct gcgtgcaagt tcaaggcaaa      840

tctaaaaggg agaagaagga cagagtgttt acagacaaga ccagcgctac cgtgatctgt      900

cgtaagaacg cctccatcag cgtgagggct caagatcgtt attacagctc cagctggagc      960

gaatgggctt ccgtgccttg ttctgtgccc ggtgtgggcg tgcccggcgt gggcagaaat     1020

ctccccgtcg ccacccccga tcccggaatg ttcccttgtt tacaccattc ccagaattta     1080

ttaagggccg tgagcaacat gctgcaaaag gccagacaga cactggagtt ctacccttgc     1140

accagcgagg agattgatca cgaggacatc accaaggaca aaaccagcac agtggaggct     1200

tgtttacctc tggaactcac caagaacgag tcttgtttaa actccagaga gaccagcttt     1260

atcaccaacg gcagctgttt agcctctcgt aaaaccagct tcatgatggc tttatgttta     1320

agcagcatct acgaggattt aaagatgtac caagttgaat tcaagaccat gaacgccaag     1380

ttattaatgg atcccaagag gcagatcttt ttagaccaga acatgctggc cgtgatcgac     1440

gagctgatgc aagctttaaa cttcaactcc gaaaccgtgc cccagaaaag cagcctcgag     1500

gagcccgact tctacaaaac aaaaattaag ctgtgcatct tattacacgc ctttaggatt     1560

cgtgccgtga ccatcgatcg tgtcatgagc tatttaaacg cttcctag                  1608


<210> 52
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Val 
                325                 330                 335     


Pro Gly Val Gly Val Pro Gly Val Gly Arg Val Ile Pro Val Ser Gly 
            340                 345                 350         


Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp 
        355                 360                 365             


Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr 
    370                 375                 380                 


Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr 
385                 390                 395                 400 


Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu 
                405                 410                 415     


Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro 
            420                 425                 430         


Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu 
        435                 440                 445             


Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu 
    450                 455                 460                 


Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val 
465                 470                 475                 480 


Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu 
                485                 490                 495     


Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met 
            500                 505                 510         


Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile 
        515                 520                 525             


Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
    530                 535             


<210> 53
<211> 1617
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 53
atgtgtcctc agaagctgac aattagttgg ttcgccattg ttctcctcgt ctcaccactt       60

atggcaatgt gggaactgga aaaagacgtt tacgtggttg aggttgattg gactcccgac      120

gccccaggtg aaaccgtaaa tctgacctgt gacacacctg aggaagatga catcacctgg      180

accagtgacc agcgccacgg agtgataggg agtgggaaga cattgacaat cactgtaaaa      240

gagtttctcg acgctggaca atacacatgt cacaagggag gcgaaacact ctctcatagc      300

cacttgctgt tgcacaagaa ggagaacggc atatggtcca cagagattct caagaatttc      360

aagaataaaa ccttcctcaa gtgcgaagcc cctaactata gtgggaggtt tacttgctca      420

tggctcgtgc agcgcaatat ggacctgaag ttcaacatta aaagttctag ctcatcccca      480

gactcacgcg ccgtgacatg tgggatggca agcctcagcg ccgagaaagt aacattggat      540

cagagagact atgagaaata ttccgtgagc tgccaagaag acgttacctg tccaaccgcc      600

gaggagaccc tgcctataga gttggctctt gaggcaaggc aacaaaacaa atacgagaac      660

tattccacaa gttttttcat aagagacata atcaagcctg accccccaaa aaatctccag      720

atgaagccac tgaaaaattc tcaagtcgag gttagttggg aatatccaga ttcttggtca      780

actccacaca gttatttctc tcttaagttt ttcgttcgca tacagcggaa aaaggagaag      840

atgaaggaaa ccgaggaagg gtgcaatcaa aaaggagctt tcttggtaga gaaaacatcc      900

actgaagtcc agtgcaaagg tggtaacgtg tgcgtccagg ctcaggatag atactataac      960

tcatcctgct caaaatgggc ttgcgtccca tgccgcgtac gaagcgtgcc aggagtagga     1020

gttccaggtg ttggccgggt catacctgta agtggtcccg ctcggtgtct ctctcagtct     1080

cggaatctcc ttaaaacaac agacgacatg gtaaaaacag cccgggagaa attgaaacac     1140

tactcttgca cagccgaaga cattgatcat gaagacatca cccgagacca gacctcaaca     1200

ctgaaaacat gccttccact cgagctgcac aagaatgaat catgcctggc tactcgcgag     1260

acaagcagta ctacccgcgg tagctgcctc ccaccccaaa agacatctct tatgatgacc     1320

ctgtgcctcg gctctatcta cgaggacctt aagatgtacc aaaccgaatt ccaagccatc     1380

aacgctgcat tgcaaaatca taatcatcaa cagataattc tcgataaggg tatgctcgta     1440

gctatagatg agcttatgca gtcacttaac cacaacggtg agaccttgag gcaaaaacca     1500

cccgtgggag aagcagatcc atatcgagtg aagatgaagc tctgcatctt gttgcatgcc     1560

tttagtacca gggtggtaac tataaacagg gtaatgggtt acctctcttc cgcctga        1617


<210> 54
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Val 
                325                 330                 335     


Pro Gly Val Gly Val Pro Gly Val Gly Arg Val Ile Pro Val Ser Gly 
            340                 345                 350         


Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp 
        355                 360                 365             


Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr 
    370                 375                 380                 


Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr 
385                 390                 395                 400 


Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu 
                405                 410                 415     


Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro 
            420                 425                 430         


Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu 
        435                 440                 445             


Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu 
    450                 455                 460                 


Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val 
465                 470                 475                 480 


Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu 
                485                 490                 495     


Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met 
            500                 505                 510         


Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile 
        515                 520                 525             


Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
    530                 535             


<210> 55
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Val Pro Gly Val Gly Val Pro Gly Val Gly 
1               5                   10  


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 57
<211> 328
<212> PRT
<213> Homo sapiens

<400> 57
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210> 58
<211> 197
<212> PRT
<213> Homo sapiens

<400> 58
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 59
<211> 335
<212> PRT
<213> Mus musculus

<400> 59
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210> 60
<211> 193
<212> PRT
<213> Mus musculus

<400> 60
Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 61
Gly Gly Gly Gly Ser 
1               5   


<210> 62
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (1)..(150) 
<223> /note="This sequence may encompass 1-30 'Gly Gly Gly Gly Ser'
      repeating units"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 62
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210> 63
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Thr Asn Gly Ile Ser 
1               5   


<210> 64
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Trp Ile Ser Ala Gly Gly Gly Pro Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Gly Leu Tyr Gly Thr Lys Asp Ala 
1               5               


<210> 66
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Ser Gly Gly Gly Ser Asn Ile Gly Ser Asn Ala Val Asn 
1               5                   10              


<210> 67
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Tyr Asn Asp Leu Leu Pro Ser 
1               5           


<210> 68
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Ala Ala Trp Asp Asp Asn Leu Ser Ala Tyr Val 
1               5                   10      


