                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Brydges, Susannah
       Kyratsous, Christos
       Baum, Alina
 
<120>  NON-HUMAN ANIMALS COMPRISING A HUMANIZED ACE2 LOCUS

<130>  09108.787WO1/10787WO01

<150>  63/093,994
<151>  2020-10-20

<150>  63/093,892
<151>  2020-10-20

<150>  63/045,183
<151>  2020-06-28

<150>  63/044,976
<151>  2020-06-26

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  2418
<212>  DNA
<213>  Mus musculus


<220>
<221>  sig_peptide
<222>  (1)..(51)

<220>
<221>  misc_feature
<222>  (52)..(2220)
<223>  Extracellular_domain

<220>
<221>  misc_feature
<222>  (2221)..(2283)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (2284)..(2418)
<223>  Cytoplasmic Domain

<400>  1
atgtccagct cctcctggct ccttctcagc cttgttgctg ttactactgc tcagtccctc       60

accgaggaaa atgccaagac atttttaaac aactttaatc aggaagctga agacctgtct      120

tatcaaagtt cacttgcttc ttggaattat aatactaaca ttactgaaga aaatgcccaa      180

aagatgagtg aggctgcagc caaatggtct gccttttatg aagaacagtc taagactgcc      240

caaagtttct cactacaaga aatccagact ccgatcatca agcgtcaact acaggccctt      300

cagcaaagtg ggtcttcagc actctcagca gacaagaaca aacagttgaa cacaattctg      360

aacaccatga gcaccattta cagtactgga aaagtttgca acccaaagaa cccacaagaa      420

tgcttattac ttgagccagg attggatgaa ataatggcga caagcacaga ctacaactct      480

aggctctggg catgggaggg ctggagggct gaggttggca agcagctgag gccgttgtat      540

gaagagtatg tggtcctgaa aaacgagatg gcaagagcaa acaattataa cgactatggg      600

gattattgga gaggggacta tgaagcagag ggagcagatg gctacaacta taaccgtaac      660

cagttgattg aagatgtaga acgtaccttc gcagagatca agccattgta tgagcatctt      720

catgcctatg tgaggaggaa gttgatggat acctaccctt cctacatcag ccccactgga      780

tgcctccctg cccatttgct tggtgatatg tggggtagat tttggacaaa tctgtaccct      840

ttgactgttc cctttgcaca gaaaccaaac atagatgtta ctgatgcaat gatgaatcag      900

ggctgggatg cagaaaggat atttcaagag gcagagaaat tctttgtttc tgttggcctt      960

cctcatatga ctcaaggatt ctgggcaaac tctatgctga ctgagccagc agatggccgg     1020

aaagttgtct gccaccccac agcttgggat ctgggacacg gagacttcag aatcaagatg     1080

tgtacaaagg tcacaatgga caacttcttg acagcccatc acgagatggg acacatccaa     1140

tatgacatgg catatgccag gcaacctttc ctgctaagaa acggagccaa tgaagggttc     1200

catgaagctg ttggagaaat catgtcactt tctgcagcta cccccaagca tctgaaatcc     1260

attggtcttc tgccatccga ttttcaagaa gatagcgaaa cagagataaa cttcctactg     1320

aaacaggcat tgacaattgt tggaacacta ccgtttactt acatgttaga gaagtggagg     1380

tggatggtct ttcggggtga aattcccaaa gagcagtgga tgaaaaagtg gtgggagatg     1440

aagcgggaga tcgttggtgt ggtggagcct ctgcctcatg atgaaacata ctgtgaccct     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccatt     1560

taccaattcc agtttcaaga agctctttgt caagcagcta agtataatgg ttctctgcac     1620

aaatgtgaca tctcaaattc cactgaagct gggcagaagt tgctcaagat gctgagtctt     1680

ggaaattcag agccctggac caaagccttg gaaaatgtgg taggagcaag gaatatggat     1740

gtaaaaccac tgctcaatta cttccaaccg ttgtttgact ggctgaaaga gcagaacaga     1800

aattcttttg tggggtggaa cactgaatgg agcccatatg ccgaccaaag cattaaagtg     1860

aggataagcc taaaatcagc tcttggagct aatgcatatg aatggaccaa caacgaaatg     1920

ttcctgttcc gatcatctgt tgcatatgcc atgagaaagt atttttcaat aatcaaaaac     1980

cagacagttc cttttctaga ggaagatgta cgagtgagtg atttgaaacc aagagtctcc     2040

ttctacttct ttgtcacctc accccaaaat gtgtctgatg tcattcctag aagtgaagtt     2100

gaagatgcca tcaggatgtc tcggggccgc atcaatgatg tctttggcct gaatgataac     2160

agcctggagt ttctggggat tcacccaaca cttgagccac cttaccagcc tcctgtcacc     2220

atatggctga ttatttttgg tgttgtgatg gcactggtag tggttggcat catcatcctg     2280

attgtcactg ggatcaaagg tcgaaagaag aaaaatgaaa caaaaagaga agagaaccct     2340

tatgactcga tggacattgg aaaaggagaa agcaatgcag gattccaaaa cagtgatgat     2400

gctcagactt ccttttag                                                   2418


<210>  2
<211>  805
<212>  PRT
<213>  Mus musculus


<220>
<221>  SIGNAL
<222>  (1)..(17)

<220>
<221>  MISC_FEATURE
<222>  (18)..(740)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (741)..(761)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (762)..(805)
<223>  Cytoplasmic Domain

<400>  2

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Thr 
1               5                   10                  15      


Ala Gln Ser Leu Thr Glu Glu Asn Ala Lys Thr Phe Leu Asn Asn Phe 
            20                  25                  30          


Asn Gln Glu Ala Glu Asp Leu Ser Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Lys Met Ser Glu 
    50                  55                  60                  


Ala Ala Ala Lys Trp Ser Ala Phe Tyr Glu Glu Gln Ser Lys Thr Ala 
65                  70                  75                  80  


Gln Ser Phe Ser Leu Gln Glu Ile Gln Thr Pro Ile Ile Lys Arg Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Ser Gly Ser Ser Ala Leu Ser Ala Asp Lys 
            100                 105                 110         


Asn Lys Gln Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Lys Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asp Glu Ile Met Ala Thr Ser Thr Asp Tyr Asn Ser 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Gly Trp Arg Ala Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn Asn Tyr Asn Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Ala Glu Gly Ala Asp Gly Tyr Asn Tyr Asn Arg Asn Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu Arg Thr Phe Ala Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Arg Lys Leu Met Asp Thr Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Thr Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Pro Leu Thr Val Pro Phe Ala Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Met Asn Gln Gly Trp Asp Ala 
    290                 295                 300                 


Glu Arg Ile Phe Gln Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro His Met Thr Gln Gly Phe Trp Ala Asn Ser Met Leu Thr Glu Pro 
                325                 330                 335     


Ala Asp Gly Arg Lys Val Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


His Gly Asp Phe Arg Ile Lys Met Cys Thr Lys Val Thr Met Asp Asn 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Arg Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Pro Ser Asp Phe Gln Glu Asp Ser 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Arg Gly Glu Ile Pro Lys Glu Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Leu Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Ile Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys Tyr Asn Gly Ser Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Lys Met Leu Ser Leu 
545                 550                 555                 560 


Gly Asn Ser Glu Pro Trp Thr Lys Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Arg Asn Met Asp Val Lys Pro Leu Leu Asn Tyr Phe Gln Pro Leu Phe 
            580                 585                 590         


Asp Trp Leu Lys Glu Gln Asn Arg Asn Ser Phe Val Gly Trp Asn Thr 
        595                 600                 605             


Glu Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Ala Asn Ala Tyr Glu Trp Thr Asn Asn Glu Met 
625                 630                 635                 640 


Phe Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Lys Tyr Phe Ser 
                645                 650                 655     


Ile Ile Lys Asn Gln Thr Val Pro Phe Leu Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ser Asp Leu Lys Pro Arg Val Ser Phe Tyr Phe Phe Val Thr Ser Pro 
        675                 680                 685             


Gln Asn Val Ser Asp Val Ile Pro Arg Ser Glu Val Glu Asp Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Gly Arg Ile Asn Asp Val Phe Gly Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile His Pro Thr Leu Glu Pro Pro Tyr Gln 
                725                 730                 735     


Pro Pro Val Thr Ile Trp Leu Ile Ile Phe Gly Val Val Met Ala Leu 
            740                 745                 750         


Val Val Val Gly Ile Ile Ile Leu Ile Val Thr Gly Ile Lys Gly Arg 
        755                 760                 765             


Lys Lys Lys Asn Glu Thr Lys Arg Glu Glu Asn Pro Tyr Asp Ser Met 
    770                 775                 780                 


Asp Ile Gly Lys Gly Glu Ser Asn Ala Gly Phe Gln Asn Ser Asp Asp 
785                 790                 795                 800 


Ala Gln Thr Ser Phe 
                805 


<210>  3
<211>  2418
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (1)..(51)

<220>
<221>  misc_feature
<222>  (52)..(2220)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (2221)..(2283)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (2284)..(2418)
<223>  Cytoplasmic Domain

<400>  3
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttgtttttgg agttgtgatg ggagtgatag tggttggcat tgtcatcctg     2280

atcttcactg ggatcagaga tcggaagaag aaaaataaag caagaagtgg agaaaatcct     2340

tatgcctcca tcgatattag caaaggagaa aataatccag gattccaaaa cactgatgat     2400

gttcagacct ccttttag                                                   2418


<210>  4
<211>  805
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(17)

<220>
<221>  MISC_FEATURE
<222>  (18)..(740)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (741)..(761)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (762)..(805)
<223>  Cytoplasmic Domain

<400>  4

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  5
<211>  45619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878 allele


<220>
<221>  misc_feature
<222>  (1)..(1377)
<223>  5' Mouse Sequence

<220>
<221>  misc_feature
<222>  (1378)..(37630)
<223>  Human 36253 bp from CTD-3010D6

<220>
<221>  misc_feature
<222>  (37631)..(37636)
<223>  Xho1 restriction site

<220>
<221>  misc_feature
<222>  (37637)..(37670)
<223>  LoxP sequence

<220>
<221>  misc_feature
<222>  (37671)..(38357)
<223>  Prm

<220>
<221>  misc_feature
<222>  (38358)..(39498)
<223>  Crei

<220>
<221>  misc_feature
<222>  (39511)..(39740)
<223>  SV40 p(A)

<220>
<221>  misc_feature
<222>  (39795)..(41007)
<223>  hUbi

<220>
<221>  misc_feature
<222>  (41008)..(41074)
<223>  EM7

<220>
<221>  misc_feature
<222>  (41075)..(41878)
<223>  Neo

<220>
<221>  misc_feature
<222>  (41879)..(42363)
<223>  PGK p(A)

<220>
<221>  misc_feature
<222>  (42369)..(42402)
<223>  LoxP site

<220>
<221>  misc_feature
<222>  (42409)..(42434)
<223>  IceuI

<220>
<221>  misc_feature
<222>  (42435)..(42440)
<223>  NheI

<220>
<221>  misc_feature
<222>  (42441)..(42929)
<223>  Human equence 3'

<220>
<221>  misc_feature
<222>  (42930)..(45610)
<223>  Mouse sequence 3'

<400>  5
aggcccatga gccctgccat ttaaagtggc tcctctctta cactctggga atgaggacac       60

ggagccagct gctgaacttc accaggataa ccattaaaat tgctttggag ttcatatttc      120

cacgatccca tgcctatgga tgccaaggac ttgtcatgga tgcgctttgg atttcataat      180

gcagagtcat tattacttcc ttgagttctc agctgagttg taagcaggta agtgaaaggg      240

aaagaggcac ctgataaagt cagctgtagg actagagttt agcatgtctc ctgagaaata      300

gaaaatgact gcttgaaact ttaccaaagc cacacaggaa gcatcaaact ccctatggag      360

tggagaagag tcttataatt ttttaaatgg gcagagaaat gaatttattt ttaattttta      420

gagacagggt ttctttgtat agctctagct gtctttgatt ggtagacaaa gctgtcctca      480

aactcagaga tcttccttcc tttgtctcct gagtgctggg attaaaggca tggaccacca      540

ctgccctgcc ccattctctc cattaatttt aagtgaatgc ttgcaaaagc tcacttcttt      600

ggtgaacagc ttcctttaca aataagtacc tttgccttcg tttttatagg attcttaaaa      660

agaaaaaaaa gattcagcca ggtggttgtg gtgcacacct ttaatcccag cagtcaggag      720

gcagaggaaa gcagatctct tgagtttgag gctagcctag tctacagagg gagttccagg      780

acagccaagg ctacagagag gaactgtcta aaaacaccaa gaaagagaga aaggagagag      840

ggagaggatg gatagcttat tgatagaatt gtcagaaaag gctataagtt ccaatatgtg      900

tcccatgatt tctaagtcta gccctttctg ttatagtaaa atcatagtac accctcctcc      960

tccagtgtat ctttaacagc ttttaaggaa catattaact aaatgtccag gttttgattt     1020

ggccataaaa tgttagcaaa gctaaggttt tctaggatta atgaataaca tgtctttatt     1080

tagtttactt aaaaaaatca ttctaaaata tctgtttaca tatctgtcct ctccaggatt     1140

aacttcatat tggtccagca gcttgtttac tgttctcttc tgtttcttct tctgcttttt     1200

ttttcttctc ttctcagtgc ccaacccaag ttcaaaggct gatgagagag aaaaactcat     1260

gaagagattt tactctaggg aaagttgctc agtggatggg atcttggcgc acggggaaag     1320

atgtccagct cctcctggct ccttctcagc cttgttgctg ttactactgc tcagtccacc     1380

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc     1440

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa     1500

aacatggtga gttctcatgg ctctattggg ctatttgttg cctcttaaag attagattac     1560

tgcccgtgaa actgaaaagg gaaatcaaaa aaaatgctct gagttgtgag attggatgtt     1620

tgcctccata tccctgattt tggcgtcgac gataactaaa cttaattgac cctggggttc     1680

attcagaaaa ttgttacaaa ataattcact ggtctcaatc cagatgcttg gaaacaagag     1740

aatattcttt ataaagttac caccataatt ctcatcacag tcaggatttc aaagcatttc     1800

atggaaatgc cataagttat tgagttaata atttccttta gcctacaata tcaataggaa     1860

tatctaaaga ttctctacaa atgatatatt aactgaaaaa tgcaactgga ggcttagtga     1920

aagaactagt aattaagcta atcagggctt gggtgaggct ggacttggga attcctttcc     1980

tctttgtcac agacctccaa gggactccaa aaggtcacag aatccaggca gagccctcca     2040

aaacaaaaac aaaaacaaac aacaaaaaaa ctatgattaa accagttctg acaaatatca     2100

gaatgctctg ggaaagccag atgctttaac aagtgcaagg atttaggaat ttcttctctc     2160

acagatccca aaacagtatc cttaagtggt gatccttatg tcaagctgtg agaatatacc     2220

tcaaaataat agaaggcatc caaacttgat cagtatagtg tcataaagct gctgatgtag     2280

aagtgtggag aggtccatca gatagagata tggaaaaaaa agcttggtta aaacaggttt     2340

ccaaagttct ctccctttct ctgccattgt ggtatgtgtg gttgaccatt tctcatcatg     2400

ttttcttaca agactttcag gatcaagcaa ttcctcgcca aaaaacaaaa tcaaggacac     2460

gttgtagcta tttcttggtg agttaccaga agctgtgaag agagagcatg aggcccatac     2520

tttttttttt ttttgaaggg tctcgctctg ttgcccaggc tggaatggag tggcatgatc     2580

atgattcatt gcagcttgac ctcctgggct caaatgattc tctcgcatca tttaacattt     2640

ttttttgtag agatgagatc tcactttgtc tcccaggctg gtcttgaact cctgggctca     2700

agtgatcctc ttgcctcagg ctcccaaagt gctgggatga caggcatgag ccactgcacc     2760

tagcctacca cacttactct ttgcgtggtc tctagagctt cttcagcccc cctgctgcca     2820

gggtccctag ggtcttgggc atgccccatt tctgaaccta ttcctgtctc cagggataga     2880

gtcacagtga actcagacca gggtaattct aaactgctat tctgtatata cccaaggaaa     2940

tttcatccct gtctctaatg agtctgtccc atgcccctta atacacatga acacctacac     3000

acaggtacaa gtcggggaag atcactgtgc agcacataaa ataaaattca ggggcgagca     3060

ctttttttcc catgagataa agttaggaaa aaataaaaat gttcatacag attaaaaatt     3120

ttaaatgtta aaatattaaa cccccaatct aaaataaaga aaaaataatt tcttaaatcc     3180

taagcttgag ttatggaatt cacattctta taatttacat tacctatttt gttaaatgga     3240

agactttttt ttttaatatg caagtacctg ggcatattta gaaagtaacc aaggcagctt     3300

ttgtctttga acctgatgcg gttttgacag ctctatctgg aaattgagcc agcatatggg     3360

agccaagggt gaaagttttc ctgggagatt tgggctccaa ggtactggat agatgctaaa     3420

gattccattc agtttttcat tttctgtctt catggaactc tcacacctac aggggaagaa     3480

atggtttaga ggttactaaa agtatatagc ctggtttagg tgatagtgag ctatagaaaa     3540

agagaaaata agttgtcagt actttaaatc tcaaacaact tcttacaaaa ggattttaat     3600

agtttaaata caattatcac aagttgggta aagacaacca gacctatggc ctgataaatc     3660

atgtatttaa tttatgcata tagttagggc caaaaagagc agagtatctt tttgaatgtt     3720

ttaaaatata atctaggatt ttatgcctac agtccttgaa attacaaagg atctctctca     3780

agttgggaat atgctatcca ttgcagttac ggatgggatt tagagactgt tttaatttct     3840

tgtgattatc tcaaacaacg tgttccttac tcccaaaact cccttgtatg gctacagaaa     3900

ctgttgcagt tttagttgct tctcccctgc ctttgcccag aggtagtgtg gaatgccacc     3960

aattttatct gtaatggttc ctttcaagcc tggggctatg taagctgcta tatatgcttc     4020

attccattca tcattcagtc taaatatagc tatcaaccac taaattatct gataggtatg     4080

catgaactga ctgattcttt gcataactac taagctatct gttttattta ggcttgggag     4140

ccctagggta aggatacgga ataaattgta aatgatatta aaagaatagc ttggcaagga     4200

ataatacctc ctcaggggcc aaaatgcaag gcaacacaaa gtgatttttt tggtgatata     4260

attataacac atgtagtatg gtagtgataa ctaaaataaa attggatagc ctcaaaattc     4320

ctacatgtag tatgataaac aatgttctaa gactgaggcc tttgggaggt agtgagttat     4380

ttcctataga tagagagtaa aattattcct ataatttggt atgaaagttt taccagaaat     4440

tttgcttcac agtaaatcat ctggattggg tgaagccagg tagggattga gaagtgagtc     4500

aggtgggttg catagatgag tttgtgctgc agaccaaact cctcttccca tagctcactt     4560

cttcccactc ctgcatgtta gagagaagac tagaatgtgt caaatacaac ctataggata     4620

atagttcaga gcattagctt cggaagtaaa cactaggttg atgccctggt tcttctaatt     4680

tctagctgtg tgacctaggg aaagttacct gctgtgtgcc tcatttccct tatttgtaaa     4740

gttgagacaa taacaactcc ctcacaaggt tgttgtgaag attaatgaaa aagcagtttc     4800

tgagaggttg tgagtgttca gtaaagaaag aaattgcttt cctttttttt tttttttgag     4860

acagattctc attctgtcat tcaggctgga gtgcagtggc gcgatcatgg ctcactgcgc     4920

ctcgacttcc ccaagctcag gcaatcttcc cacctcagcc tcctgagtag ctgggactac     4980

aggtgcgagc caccacacct ggctagtttt tgtattattt gcagagatgg ggtctcgcct     5040

tgttgcccag gcttgtctca aacttctggg ctcaagcgat cttcccacct caacctccca     5100

aagtgctggg attacaggca tgaaccacta cacacagcct attttccatt ttcactgcca     5160

ttattttctc tgtctcttgt gtggctcatt actgccactt ctgtgcacca tttccatcat     5220

gtcacatgcg tagtcaaaac cctcagtgac tgcctaattc tcagagggta aaagtgaaat     5280

tccttggcct ggaaagtgca atcatgcctg aagttctacc tgtgggagct gtactagtta     5340

tctattgtgt aaaaagttac cacaagctta gcagattaaa acaacacata tttaatatcc     5400

cacagtatct gtgggctagg agtccaggca cagttcagct ggatcttctg cttctaagtc     5460

tcatatggtt gcattcaagg tgctggctag agctatggtc tcttctgagg cttgactggg     5520

gatggatata cttccaagcc aatgcaatta ctcagaggcc gtctttaatt atttgccatg     5580

tggccttttc catagggtag ctcacaacgt ggcatcttgc tgcaacaagt cagcaaagga     5640

gagagtcttc tatcaagatt aaagttaaaa tcttatgtaa cgtaaacatg acatcctgtc     5700

acctgtgttg tatgctattg gttgaaagta aatcacgggt ctgctcatac ttatggggag     5760

gggatcacac aagggtgtga ccaccaaagg cagagatcat gggagcattc ttagagtctg     5820

tctgccacag ggccaggatc aaatgctggt ggctgattgc cagctccact gtttatttct     5880

ctcagccgct ttctgtatgt acaaaaaagg agagagagtg attttctacc tcatagtgtt     5940

gttaagaaaa tcaaatgagg taaattattt tgcaaagtat tctctactca tctgactcct     6000

acctactttc aggtctgtct taagttgcaa cttctgcatg agggcttggc caagtatggt     6060

cacctgcatg aatttcctct ttcttgtaac agaaactgct tggcccactc ataatttata     6120

cattattata tactcttatg tttcattaat gaaacattta taatgcatat cttatctgtc     6180

tgataaaatg gaaagcaatc taaggacaat gacttttccc ctatacataa caaaatataa     6240

aataaatcat aacataataa ataataaata aataataaaa taactaacat ttgttgaatg     6300

attaggatgt gttaggcact cttgtaagca tttcattttt ttgttacttc ttcaaatcct     6360

tacaacagtc cttggaggta agtcctatta ttactttcat tttgcagata agacaactgt     6420

ggctcagaga ggctaaggta cttgagtcca ggagcagaat tcttactttc ctcaaacgtt     6480

atctcttttg tgtggtctag ggcagtacaa tataccaagt agttgctcat tttggtcttt     6540

ggtaaatgga aatgaatttg taagttgaga aaagactaca ctacagtagt ttggagaagt     6600

ccactttcca actgatgttc aagattcagg agggggggaa atgtgtcctg gcatcatcac     6660

ttgcttgatg atttcttttg ctggtagaaa atcaccatgg ctaccaatgg ccattttctg     6720

ggaagccttt tttgggaatc ctaacttaag atcaaaatcc ctgggctaag tcacggcagc     6780

taggaggtta ctgtgaaccg gttctcattt cttatggttt ccattgttat tagggggctg     6840

tattctcatt aagtccactc tgagctctac tggattctct ttttagagca ctcgtctttg     6900

aattcttggc caactcatct atgtcacagc actaaggcta taaattccag ggccccacaa     6960

tgtggattat ctgtgagaat tcatttccag ttctggggac aagacccttg ggaaaaccag     7020

gcaataggcc agagagagac agagagagag agagtggtca aaagtggcct ggtcactctt     7080

aacctaaacc ttgaccttca gcggagtaga ggactaaatc actcaggaaa tattaaatgt     7140

ttcaccagat attatttgga ctatatcttc tgttctatct cttcaagcaa tgccattcca     7200

acttcaattt tcttttctgt catttcagaa taatgctggg gacaaatggt ctgccttttt     7260

aaaggaacag tccacacttg cccaaatgta tccactacaa gaaattcaga atctcacagt     7320

caagcttcag ctgcaggctc ttcagcaaaa tgggtcttca gtgctctcag aagacaagag     7380

caaacgggta cgtttgtgaa cattttagca ttgatcccaa gagttgaaat atttgggaaa     7440

tattaaacat taatatcacc cacagcagct gcctttattt gaaaaaatag taatgctgat     7500

gttagaaaaa tctctctcta tgcctaggta aggtgtccat ataatttatt attcaaactg     7560

gaatctttga gagtgaaaga cactggtaat tattatattc aaacacagag ttaaactgag     7620

attgtccctg gcactgtggt gtgtatggac accccctagt gttaggtcac cttcctgaag     7680

gatcaggcag cctgaagaat acagttagtt tatgtcagtg gttctcaact gggggtgatt     7740

tagccctccg gggatatttg acaatgtctg gagacgtttt tggttgccac aaatggggat     7800

actgttgaca tctagtgggt agggatgctg cagaacattt cacaatgcat gggatggccc     7860

ccaacaacaa agaatgatct tgtccacaat gtcaacagca aacttttttt tctgtaaagg     7920

aacagatgac agtaaatatt ttaggttttg tgtatttagg tattgtctgt gttgcaacta     7980

gtcaactgtg ctgttgtatc aggaaatcag ctgtagctaa tatataaatg aacaagtatg     8040

gctgtgttca aataaaactt tacaaaaaca ggcagcagac aggatttggt ctgcagaaca     8100

cagtttgcag acctctgata tagcctattg aaatattttt aacctaaaat atttagctat     8160

ttaaaaagaa agtcttcttt ctcagttgct tgtcctctgg aactttgtat gttctaatct     8220

gtgaatataa aaataaaaat gcatcaaaaa ggcaaagata aaaccatgtg aaatgtatct     8280

ttctacaagt taacatttat ttttctgcat tctttgggtc caattatcca actaattatc     8340

aatgcacttt actttatcca ttctatgttt ctccattttt tcccccaaca aggacactat     8400

aagaaacctt gcccattcgc atatagacaa tctggtctag cctaggtgga acctagaaat     8460

tctatttttt aaaaaatccc cagataattc taatgtgtag ccaggactga aaaccactga     8520

aatgcatgta agagcttaaa gtgtttggga agaggaggga ctcaaggttg cttagatttg     8580

atggagagga agccgtggag attgaagaag agctggagag agaccatgag gggttttgtg     8640

ccatggtaag gaatttaggt ttgttccttt ggactatggg atcgtgtgga agttttaaac     8700

ataggatcta tttcatgttt taggatgact ctcaaggcag aaccaaaggg aaataggaga     8760

aggagaaaca gatcctttaa tccagtgctt cttaaatcaa tctgagggag agaaccattt     8820

ccttccttcc ttccttcctt tcttctcttc ttccttccct ccttctctcc tccctcccgt     8880

ctttcctttc tccctccttt attcctttat ttccaataca ttgcagatca atacttgctt     8940

aagttcattg attacatgct tagatgtcat ggaaatatca aattgttctc caaagtttat     9000

aaacttttat tctcttaatt cctgtactta tcacagaatg gaaacaaact gtcacttgca     9060

ctggtccacg gattacacct ggagtagcac tgcttcacta tatcaccttc actttatctg     9120

cagggtaaag tttaaaaact ttggtatggc atagacggtc cctcgtgatc tggcccctgc     9180

ttgtctctcc attctcatgt ctttcatttc ccctaatgaa caccattgct ccagtttcat     9240

tcaacatctc actgtcccct gagaatgcct tgtcttttcc aacctccttc catcttttag     9300

actcttccct ctacctccct tctctacatg accagtgcct acttcttctc caagacacag     9360

ctcttatctt cccttctctt tggacccatt cttgaatctc ctggttatta gttattaatt     9420

tctccctgct cctatactac cgcatcactt tttggtgaca gttatagcac ttgtcattct     9480

gttatgtatt aatagttatt gatttcatgg ctgcctcact gtcctatgac tttatggtct     9540

ttgacttgtt cacttcagaa ttgtcagagt gtaggacata ttccaggttc aataaatgct     9600

gaatgaaaca aaaaatgcac ctctctgtgt atgtgtggat aagaaaactt ctttgggttt     9660

tggtagatct ggttatttca attactccat atatatttat tatgtgctta tagtactttg     9720

tgctagtcga cagtggggaa acttaactgg gctattcctt ctccacatac agaaagatac     9780

atggcaaaga agtaaattgc tgtattttga gtaatcaaaa aatcatgtgg tcaaaaggat     9840

atctttatat tagcattctc ttcagcaaaa tttccattgt taacattgtt tattatcttt     9900

aatttgcagt tgaacacaat tctaaataca atgagcacca tctacagtac tggaaaagtt     9960

tgtaacccag ataatccaca agaatgctta ttacttgaac caggtaggct actaattttt    10020

agtagtgatt atgaaattta cttttctctc agattttaaa aatgattgca gatatgtgtg    10080

tttcaacaca tagatgctct tttaactttt agtaaaactt tcttgtaaat tgtatcacat    10140

ttacttaatt tgatcaagtc agtaagtaag tcatttcagt ggtttatttt ctctgcagac    10200

atattttgga actataaggg caaggacatg aatgaatcat gagattttat ttaaccactt    10260

tatgacctga tgtctgccaa ccttactttt aattctttaa agttcatgta gttctttaca    10320

aataaaattt ttacaaaggc atcttttctt gtctttgtgt gctttgggat aacaggtttg    10380

aatgaaataa tggcaaacag tttagactac aatgagaggc tctgggcttg ggaaagctgg    10440

agatctgagg tcggcaagca gctgaggcca ttatatgaag agtatgtggt cttgaaaaat    10500

gagatggcaa gagcaaatcg taagtttgct gatctgtaga ggtcctgaag ctctctgtgt    10560

ggccacgggg ctatttcttc tgcattacca agcctgccct ttgatatcag ggatacccct    10620

caattaacaa tcatgtcctc aacaattcag attacctgtt ttcaaaagaa attactgggg    10680

aaaaagaaaa ggtgcactgg cattctacaa ttcaagaagc tcaagaatga gactcaacta    10740

caaggcctaa agtaaattat ccaggaatta tgaattataa gtaatctagg aagatctcag    10800

gcccctaaaa gttcccgagg gagtctgggg attaaggggg ggaatcccat ttctcaggat    10860

gaaagacaga gtcactgcct tttgtctaaa gcccccacag ttcactttca aaggtcattt    10920

gtgtgtctac cttagggtga taccccagaa agaaaaaata tcagattagt ttaggctgga    10980

aatgtattat tttctgcagt tgtaattata tctcagatta tgtggtcata aaaaatctta    11040

acataggaag gaatttccat atctcttaac ttattctctt ccctgaatag tgagctgaag    11100

tcatggaatc atgattcaca ttttgctttg atgatttact gcccactgag gttgagtaag    11160

gaagaatttt tttcccgcat ttgttgtttt aacatttctt tcactgccac ttaaattcag    11220

tattcttaag ccttaggcaa gctggagaca atagcttatc accattttta aaacaatatc    11280

ctgcatgtcc tttcatccaa atatttattt ctctcctcat cttcctgatc attaattgcc    11340

aatgtgaatg taaaaataaa aattattaaa ttatgtttac aaactttatt agctaatatc    11400

ctaacacaag cttgtgtttt ctgatggtga gatactaaag gaagcacata gaaacatgct    11460

attgatacat ataatttgca aacaaacaca ggttcactgt ggcaaagtct aagatgagtt    11520

gggtctgatc taaaaataaa aggccatgaa caaaagaaga atttaaaaac ttagagatcc    11580

agtcacatat tttaaagcta aagatacaaa ctgatgtatc aagagagtac acacccaggg    11640

ttaagagact aggaatgtgc ttctttcgct taccagctgt gtgatcttgg acaagtgatt    11700

taaccactct aagcacaggt tgttggtggg aatataaact ggtgaagctg ttatggaaaa    11760

atagtatgag gattcctaaa taaattaaaa atagaattac cgtatgatcc agcaatccct    11820

cttctgggta tatacctaaa ttagatgaaa ttaccccttc ataaagatat ctacactgcc    11880

atgttcactg cagcattatt cgcaatagcc aagataggga aacaacctaa gtgtttgtca    11940

agggatgaat gaataaagaa accgtggtag gtatatggaa tgggatatta ttcagcctta    12000

aaaaagagga gatcctgtca tttgcctcaa catggataga cctggaggac attatgctaa    12060

gtgaaataat ccagacataa aaagaaaaat atggcatcat ctcactcaaa agtggattct    12120

acaaaaaaat caaatataca gagatagagt aatagtgatt accaggggtg aggtggagcg    12180

gggtgggata tggggagaag tgggttaaag gatacaaagt agcagatatg caggatgaac    12240

aagtctaaag atctaatgta caacataagg actgtagtta gtaataatgt tttgtattca    12300

ggatttttgc aaaatgagta gattttagct gctcttccat gggggggata atgcttaact    12360

atgtgagatg atggatatgt taatttgttt tactatagta accattttat tatataagta    12420

tctcataaca tcatgttgta caccttaaat atacacaata aaatttattt aaaaataaac    12480

ataggctgtt actctgcaca gtgggagtta taataatgac aatcttgtat ggttcttgtg    12540

cttattaaat aaaataatac atttaaactc ctggcacaga gcaagtgctt aaacagagat    12600

tacttaatgt tattattcat ttgcatccct ttgagttgat gtttatcaca ataaaaatgt    12660

gataagcctt taaatttctt ttaacctccc agcaaggcta atctgtgtat tttgtgcttt    12720

ctctctttct ttcccttatg ttcttccctt tctctttaaa aaaaaaaaca aacagattat    12780

gaggactatg gggattattg gagaggagac tatgaagtaa atggggtaga tggctatgac    12840

tacagccgcg gccagttgat tgaagatgtg gaacatacct ttgaagaggt aagcaaggaa    12900

ctgtacacac aaacagttgt ggggcagtgt atgggaaaga gggacagtga ctaaaggcat    12960

tctggctcat tcttaacaca ttggtcagcc attcccaggc ctcataaagt tatggaatat    13020

tagagtttga aagattttag agaataatag gacagcccct acagatgatc agaattgcgc    13080

tgctttcctc cttctttcag tcactgacca ttaattacca atagaaagac tataagaatg    13140

aaatattata agaacaaatg gtcctttaga ttataagtag gaatgatctt cttgagctac    13200

ctggggctgg cactgtcttc ctgtgttagc agagctatgg actttgcttt cttcctcagg    13260

acaattgata ctattacttt gagtaagcta gtcttcatag ggaagagaga gttttgtgaa    13320

cagaaatgtc ccatggatgt ttttccttca ttttggcccc atgcctcccc tttacgtgaa    13380

ccttcaaact tctgatgtga gttaccttgt cacagccata gtttggcaga gctatcaaaa    13440

atggaagtaa gacaaacaac tccccaaaaa ggaaatggga agaagacttg aataagtaca    13500

tcatcaaaga aattacacaa atggcaaata ggcaaataaa aagttattag ggaaatgcaa    13560

attaaagcta tgatgaaaat ccactccaca cccaccagga tagctatgat taaaaagatg    13620

gacaatacca agtattgggg agaatgtgga gacactggag ccctcttaca gtgcaggaag    13680

aaatgtaaaa tggggcagtc actttggaaa acagtttggc gatttcttaa aaagttaaac    13740

acacacttac catgactctt aggtttctat atgaaataaa tgaaaacatg tgtccttatc    13800

catagaaaga catacacaaa tgttcatagc agcaatattc ataatagccc caaactggaa    13860

aacccagctg tccttcaact agtgaatgaa taaacagact ctgatatact caaagtagcc    13920

ggagatagga gtggaactga ctacaagaaa ccttttgtgg ttatagaaat attaaaaaac    13980

tagatagtgg tgatggtttc ccggtagttt taatttattg aaactcatgg aactacacac    14040

ttgaaaatgg gtggctttta tagtatgtaa attatacctc aatgtaaaaa caaaggaagt    14100

aggtaacaat cttaaaaatg aatatatatt ttttgcatct gcttttattt tgggacctgt    14160

gttctcccaa gtatgtttat tggtttatgc agtggagtta tcatcaagtt ctaggaagaa    14220

ggaatacttt taaattttcc agaaatttga gagaagaaga attataattt ggggaaattc    14280

tacttgttta aagaatctcc tatttctagt gttgtggaat ggaaattaga attggttact    14340

ctttgtctta aactttcttc ctgggctttt cagattaaac cattatatga acatcttcat    14400

gcctatgtga gggcaaagtt gatgaatgcc tatccttcct atatcagtcc aattggatgc    14460

ctccctgctc atttgcttgg taagaagccc catgaattct tcgtgtactt ggctctttgt    14520

tatttctaac aataaaattg cctttttgag tgagccttaa cataaaactt ttgaaaaatt    14580

ctgtaagtgg ttagtaacat tgtagaaatc gcattttgaa agcattttct tcaaccaaaa    14640

gtctatttta aacaattctc tattgtatta ctttttttgt acataaagag ttattatttt    14700

ggctgcaatt caaatgataa aggggttatt taagataact agagaaagaa ttacaggctc    14760

aaatgagagt ggaaatgggg aaaataattt ttagtattca agttgattgg ctaagctctt    14820

aaggtggaat ttgagatttt agtatcatat tgtcagagct tggttggctg ggggtggtca    14880

ggggtaacag aaggttatag cttgagcgaa agcttcctaa gttcattcta gacttcacca    14940

attactcttg ctgaaaagtg cttggcttgg aatcgtataa gtgaagaatg aatgaaagtg    15000

accatcttcc cctctcccac cgcagcagct gaggccaaat aaaatataaa tatttgaaaa    15060

tttcatgcca tgcatatata gcatttctac tgtagtcaaa ctaagttgct ggaagctaat    15120

ctcctccaca gccatacctc gtgtctgtca gcaggagaga atgcggagaa aggacctgtg    15180

gaggctttta actctaaagt aatatggaaa tccttcctac aatgtcaatg gcaagcagta    15240

tttagtaatt cagtttctgc ttaaacctgt ctggtgtgat gggataattt cttcattcca    15300

atatagacta atttactgct acatggaacc aatgtaatac aattctacct tatgtggaac    15360

ttaagcaaca cccctctgat gccttccatt cattagccct atttccatgc tatgaggtta    15420

cccagaatgt caattcctat tctacaagat gaccttccag atattcataa agaaccatca    15480

tataagatat agcatagtac ctggtgcaat acattttagt gactattatt gttattgtca    15540

tgtttaccct attttctttt gtcaagttaa atatcttata cattatcaac cattccttaa    15600

aacctcactt ttctataatt gttctccttt caatgagctg tactttgtca atgtccctcc    15660

tcaattatca tgcttagaga tgaacagtta ctccagatga ggtttgacca acataaagaa    15720

agacatggta ccatgactac ctttgttcta gacactatac ttctattgat ttagctcaag    15780

ttcacattta tgctttagaa gccaggtcat actgtttgtt ggctcatttt tggtctttta    15840

catgtggact gtgctttagc ctgatgtcac atatatgttt ttatgatgga taggtttttc    15900

tttaaaattt aagcatagga cttcacatgt atcactacta aattttatgt tttaaaatat    15960

aagtttaggg agtactttta tttttttcag agtctcgctc tgtcgcctag gctggagtgc    16020

agtggctgat ctcagctcac cgcaacctct gcctcctggg ttcaagcgat tctcctgctt    16080

cagcctcctg agtagctggg attacaggct caagccgcca tgcccagcta atttttgtat    16140

ttttagtaga gacagggctt caccatgttg gccaggctgg tctcgaactc ctgatctcaa    16200

gtgatctgcc tgcttcagct ctgcaaagtg ctgggattac aggagtactc ttcatgaagt    16260

ttgttgcccc atttttttgg caccaggatt ctggtcctgc tcttggattg actttttcta    16320

gatacatctt cttttttatg gtccctggcc ttggaataca acttaacatt tgtttgagat    16380

gtttacaaag tcaccaagtt aagtacacga atataggaat aaaagtggaa tttagttacc    16440

agttagtaga agttcctgaa tgatgatctt atatgatctc ttttgaagcc aacactagga    16500

attactaaca gcttaatttg taatattttg taccatggat ggtagattat agaaatctct    16560

ttctaattta cagtgtcaat gatggtccat atatttaata aattatgtct acatttctgc    16620

tgtgttgtca tatactaaca gattcttttt taaatatagg tgatatgtgg ggtagatttt    16680

ggacaaatct gtactctttg acagttccct ttggacagaa accaaacata gatgttactg    16740

atgcaatggt ggaccaggta ggaaaaagag cccttaaaaa ctaaatctaa attctcaact    16800

tcatttattt ttatgtcatc cttctatttt tatttttatg tgaaaccatg taaataaaaa    16860

atttaagcta attgaaattt atttcttatg tagctatagt ttcatggaaa agcagtttac    16920

aatggcctca gataacttga attgcaggtg tagtattgat ctcattgaaa ggtatttgaa    16980

atggagatta cctgagtttt ccattaagcg gtaagatgta gaattgtcaa ctggttggta    17040

tcactcattc caaagtttgt cattgctaag taaccagcca gtaatctcta tggatagtaa    17100

aaacaagaat attatgaggg gatttttgca tatttaaaaa attattagtg ttaaaaatat    17160

tacaagaatc tttaaaacaa ttttaagtaa catctttatt actactttgg tttaattatt    17220

taaatgtgct aggttcctca aaacacaagt aagtacatag cccatggacc caataaagca    17280

actacacaat cgagactaca aagcaaccag ctaacaacag catgacagga acgcttcacc    17340

taacagacag agagtggcaa attggagaga aaaacaaaac ctaaccttct actgtcttcg    17400

agattcatct cacgtgtaat gacacccatg ggctcaaagt aaagtgatgc agaaagatct    17460

atcatgcaaa tagaaaacaa aaaagagcag ggggctgcta ttcttgtatc agataaaaca    17520

gactttaaac caacaacagt aaaaaaggac aaagagggtc attacataat gataaagggt    17580

tcaatttaac aagaagactt aattatccta aatatatatg cacccaacat tggagtatcc    17640

agattcataa acatagcact tttagaccta ggaaaagact tagacatcca gaaaataata    17700

gtgggggact tcatcacccc actgacagtg ttatacagat cattgaggca gaaaactaac    17760

aaagaaattc tggaaattct ggacttaaac ttgacacttg accaattgaa cctaagagac    17820

atctatagaa tattccaccc aacagctatg gaatatacat tcttctcatc tgtatacgaa    17880

acatactcta agactggcaa catgctcagt cataaagcaa gtcttaataa attcaaaaaa    17940

ttaaaattat gccaaacata ttctcagacc acagtagaat aaaaatagaa atcaatacca    18000

ggaggaactc tcaaaaccat gaaataacct ggaaactgaa caacttattg ctgaatgact    18060

tttgagtaaa caatgaaatt aaggcagata tcaaaaaatt ctttgaaaca aatgaaaaca    18120

gagacacagc ataccaacaa catatctggg atgtggcaaa agcaatgtta agaggaatgt    18180

ttatagtgct aaatgcctac atcaagaacc tagaaagata tcaaattaat aatctaacac    18240

cacacttaaa ggaactagaa aaacaagaac aaactagttc caaagctaga aaaaaagaga    18300

taactaaaat cagggcagaa ttaatgaaat tgagacctaa aaaatcatac aaaggatcaa    18360

caaaatgaaa agtcagtttt ttaaaaggat aaacaagatg gaaagacctc tagctagatt    18420

aacagagaaa gagagaagat ccaaataagc acaatcagaa atgacaaagg tgacattgca    18480

actgatccca cagaagtaca aaccttccta ttgagtacta tgttcatatc tggttgatag    18540

gaccaataga aacccaacgt cagtatcaca caatataccc ttgtaacaaa cctgcacatg    18600

tactccctga atttaaaatt aaaattaaaa ttaaagttaa aaaattatca ggccgggcac    18660

ggtggctcac agctgtaatc ccagcacttt gggaggccga ggtgggtgga tcacgaggtc    18720

aggagatcga gaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa    18780

aaaaaaaaaa aattagctgg gcatagtggt gtgcgcctgt agtcccagct atttaggagg    18840

ctgaggcagg agaatcactt gaactcggga ggcagaggtt gcagtgagcc gagatcatgc    18900

cactgcactc cagcctgggt gacaaagtga gactctgtct caaaaaaaaa aattctctgt    18960

gttcccttct gttgatgaaa tggtattata gttataatta tgtatatttg ttcattcaac    19020

taaaattcta cgtttctgag tagaatatct aatcatattt ctatttgcct tataaaattt    19080

attcagataa ttgcaccata atttactatt tgtgcattgc tgaacctttg cttgttaata    19140

gttttacatc tgtaagaagc aatgcaatga acatcttcac atacataaca tactcctggg    19200

aaaagtccac tgcagaataa aaagtgaaac tgcaagggcc tctaaactct tgtagctgtt    19260

gtagctccac tttgaagttg agcagcagta tagggccatc ttgatgtaga tttttagtct    19320

ttctaaaggg tttttacacc cgtctcttct attgtcatct ctgactcagg ataggtattg    19380

tgacagctcc atgctatagg tgaggaaact gaggctcagg taaatgattt gcccaaagtc    19440

acaaatcaca cagcctcatt ctttctgttt tttttgtacc aattaaccat cctcacctgc    19500

ccctgccacc ttcccactac tctttccagc ctctggtaac catccttcca ctctgtatgt    19560

ccatgagttc aactcttttg atttttagat gccataaata agtgagaaca tgtaatgttt    19620

gtctttctgt gcctggctta tttcacttaa tataatgacc ttcagttcca tctacgttgt    19680

tgcaaatggc aggatttcgt ttttttatgg ctgaatagta ttccaatttg tatgtgtacc    19740

acattttctt tatccattca tctactgatg gacacttagg ttgtttccaa atcttggtta    19800

ttgtgaatag tgctgcaaca aacatgggag tgcagatatc tcttcaaaat actgatttcc    19860

tttcttttgg gtatataccc agcagtggaa ttgttggatc atatggtagc tctattttta    19920

cttttttgag gaacctccaa actgttttcc atagtggttg tactaactta cattccttcc    19980

aacagtgtag gagggttccc ttttctccac accctcatca gcatttgtta ttgcctgtct    20040

tttggatata aaccaaaaaa tttttcataa atataatttg ggtggctgca cattattcta    20100

tttttcaaag gtatcattat ttatttaacc attctgatgg tcgtttcaac tttttctcta    20160

ttaaaaataa ttctcaatgt aattgttgaa tctaatttct gataattttt taggttagtt    20220

ccttagagac agcattactg agacaaagag aagaatttca aatgctatcc gtgtgtgtta    20280

tcaaattacc ttttggaaag gttatgccaa tgtatatatc caacagaaat aatgctgcta    20340

ttttaaaaat gacattagca cttttttcca ttttaaaatt ttattgtaaa ttgacattta    20400

ttattgtata tatttatggg gtacaaggtg atttcatgat ttatgaatac aatgaaaaat    20460

aattaaataa agctaattaa catatcaatt acttcacata ctttttttgc agtgagaaca    20520

tttgaaattt actctcttag caatttcaaa atgtacaatg ttctattatt aactatattt    20580

actatgctgt gcagtagatc tcaaaaaaat aaaaccaact tattcatcct gtttgagact    20640

ttgtacgctt tgaccatcat ctccccgttg cccccacccc atagcctctg taaccaccat    20700

tctactctct gcttctacca gttccattgt tttagattcc acacataagt gagaacatgt    20760

ggtatttgtt tttcggtgcc tggcttattt aatttaagaa tgctgttgtt ttgatgctgg    20820

aattaatact gttctctttt cccaggcctg ggatgcacag agaatattca aggaggccga    20880

gaagttcttt gtatctgttg gtcttcctaa tatgactcaa ggattctggg aaaattccat    20940

gctaacggac ccaggaaatg ttcagaaagc agtctgccat cccacagctt gggacctggg    21000

gaagggcgac ttcaggtagt ggggctgata cttacacaac tgatactaaa tgggagacaa    21060

cagaggcagg ctgaagttta acttgaattc tttctctgct tttctgagca cagaaaagat    21120

aagttaattc tccttgaact aaggctggga gtccaggaga gcacatttgg gttttcccag    21180

gaaaagagga ttgccagcag gctctaactt gaacctgtgg acaatctgct ttcttggaaa    21240

tatcatgcat ccattggcgt tgtatggtaa tggggatggt tgcacccata tcaggaaaga    21300

tttggtgcta agatttttgg aagatggaca tatgaatcac acattgatct tcccctccat    21360

gtttcactct tgtgaatgag acagaatagg tgaataaata cgcttggatc gaagggagaa    21420

agtggtacat gtcgtaagag agacacaggg catgctctat ggagaactgg aagaaaactg    21480

accacatttg caataggaga taggatcaga ccgtgcttta caagtgggat ttgaattagg    21540

tttggaaaga caagaaggat tcagatacac agagtcggga ggaggaccca agctgtgaga    21600

acagcaggat caaatacaga gaggcaggac ctgacctgca tactgaagtc ggcaagttag    21660

gctagaatga gaaataagtg aaggagagtt tgtgtaatgt ggcagaatga gcacaggctt    21720

cagaatccta ggtgtgtcac ttaatgacta tgcaaccttg gacaaggtat ttaactttct    21780

ttggtttcag tttccttatt ttataaagta gaatagtaat tcccaggttg caggcttgtg    21840

agagccttag gttggattcc ctagcttgaa aaggagatcg ttttacaagt gcttcattga    21900

ggagagctct gaggcagagg ggaatgaggg aagcaggctg ggacaaagga gggaggtaag    21960

taagaatgtg atctttactg gaaacttggc ctcagcctta tcccatgaag ctctctggag    22020

cataacttga gccacagact aggccacacc tcaagacaag ggggctagcc ttttatatca    22080

ggcagtcttt ggctgtggac tgccccagag tatgggggag cataaccccc atttagccaa    22140

aggcagtgaa gggagcagct gtaggccctt atcagctgtg actcaggcag ctaggggatg    22200

gtggataaag tcttggcagg cccgcaccag cattgactag ggtagggatt ggatctacag    22260

tccttttctg taaagggcca gatagtaaat agtttaagct ttgcagatct ctgttacaac    22320

tactcagctc tgcccttgtg acatgaaaac agccatagac aatacacaaa ccaatggatg    22380

tggctgtgtg ccaataaaaa tttatttata aaaacaatgg ctggccagca ggccatagtt    22440

tactgatgcc agtactagag tgaggcttaa aaatgagaaa gtataagtaa gttttcaagc    22500

acagaatctt acatacagta ggcagtaaat atatagtagt tatttttata attatttcaa    22560

aagagaatag agagaaacca aattagaaaa gtaggttggg gttgtgaaag gaaaatagat    22620

ttactgagca tgagatgaat acataactga atatttcctt accttccccc tttctcttgc    22680

aatgtgtgaa ttaccatgcc ctcccactat cctctccagc tcacttttct cctataaatg    22740

ttgaagccct caaaattatt tttggagaaa ggcacaaacc acagactgtt tctataaatt    22800

ctgtgttctt ttcttctggg catgttctta accttggcaa aataaacttg tgaattgatt    22860

gagacctatc tcaaatagtt tttggtttac agggtcatat tggtgtataa aaggtggctg    22920

agtttattct tgagcaatga ggaggcctcg caggatattg gagggggtgg tgacatgatc    22980

caagtggtat gaaatacatt taggaatcta ctgatgtatg acccctacac ccatctgaat    23040

gaaaatgctc ttgctaagtt aaaaaggacc accatctcat tgccaaatgc agttcttatc    23100

ccactgggct atagcagcat ttgacaagat ttacaagttg tctttcaaat gctttttttt    23160

tttaaccgac ttccacattg tcattctttt ccagatttcc ttgacctctc tgattgtact    23220

ttctccgtct cccctgaata atcttcctct ccccactcct taggtacttg gaccttctaa    23280

aggtttatct ttggtcctct tttcttgcat tctatacctg ttccatggcc catcatatct    23340

atttcccaac ttacatgcta atgattccca agtttcaatt tgcagcccct tctactattt    23400

ctctatcctg gcaataccaa acagcgtgca gtgtcctgaa tgccacattt ccacccccct    23460

gcccctaagc ctttctcatt gagcactaga acgtcaactt ccatgtcatc taccgggcaa    23520

actcctgcac attgattaag gtccaaattg ctcattgtat cctcagtcat gcccttcttg    23580

gtgcttctag ggaactgtgc ctacattcac tcatttttac gctcaaggct gtgtgtactg    23640

atcacttata gagtacttgc ctcagagttc ttgtagcgga gaactctgct tatctgtctt    23700

cctgttagtc tatgagcaag agaacaggat tcagctgtgc ccattgcttt atattgagca    23760

actagtattg tctctaggac ataagaggtg ggtactcaag attcactggt gaataaatct    23820

tggaaagatg attcatgcta ccaaaacccc atacaactcc actgtaatgg ttaaatgaaa    23880

gtcagtgaga ttcattttca tcttgtccat tttcatgcag gatccttatg tgcacaaagg    23940

tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag tatgatatgg    24000

catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc catgaagctg    24060

ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc attggtcttc    24120

tgtcacccga ttttcaagaa gacaatggta tggacatttt ctcatggctt gttttggagg    24180

ttctttaatc tgatatggga aaaggtattt attatcttat gtaggaaata tttacttttt    24240

gccacataag gtatgaggta tttatgggta actggaaatt actactggtg aaaaaattta    24300

agtatatatc agaacatgtc aacttttggt tttgtattat tgaaaaggga ataagagagg    24360

taactgaatg aatggacttg ggatcctgtg aaatatctaa cagaagtttt tttcttaaag    24420

atgatgaaac agtctcacag aactgaaatg gcttgtccaa ttagtgtcag cattctaact    24480

agacccctct ggttctaggt aaaaacttcc caaaacttta gagttggaat atattctaaa    24540

aaccatttta tagaggagta aactgaagac aagagaggga aagtagcccg aagtcaaaac    24600

gcaatgtagt ggcggaacca gaacaagagc cctaatctaa agtcttttcc ataatattat    24660

gcaaagcaaa gtgtagcttt aaattttgga attcttaaag aacaggtgtt taatatcaag    24720

attagaaggg attgaaacat tttgttcatc ctgctgaagc gtgaatttcc cctgtaacat    24780

ccccttagat ctgtgctatc cttcaacatt tctgcctgag gcagcccatt tccttttaga    24840

tgccttggac ttgatggaac atgacaaatg ttcaggagat ccaatttctt cagtgaggat    24900

gccatggctt ttgattcttc ctcataaatg gaggacaaat agagcctaat accttcttct    24960

cttctgtata ttctctcccc tatttttagt tatttgtgac ataaagatca gctcctctgt    25020

ctggagcatt tggtcgatga ggtcaaggtc atgagctcca tccttgagta gacaattcac    25080

tttgccttga tctctggttc cagatacttg gtgatcccac aagggcctgg gagtgagcca    25140

gtgtaaagcc tatcatcatg tttgaaatag ttactgtaag cacagtccta gtggattaca    25200

gaccagtagc agcatcctcc catgaagaca gtaacaaaca aaggtagtta acagtaacca    25260

tacctgcttc ctaattttaa aatatcatta attcaagtca atgaacagat attttattat    25320

ttttaaatat tccctgacag caggtaaaaa tggttgatga ctatgtttct taagatgata    25380

ttagatcagt gatgaaataa tctgtacaac aaaccccatg acacgagttt acctatataa    25440

taaacctgga cacatacccc taaacctaaa ataaaagctt tttttgtttt tttttataaa    25500

aaagatagta ttagacatgg ttaaaccacc ggtttggaaa actcctgctt tttttcttga    25560

ctctgcccct gatttgtgaa taatgttaaa taaattcctt tattccttcc attcctccct    25620

ccctctttct ctttctttct tcttccaaac atatttatcg agcacatact gtgtgcaaga    25680

catttttcta gacactggag acacagtgat gtgaaaagta gataacatcc cctgcttaca    25740

tttcaatgca tttccttcat acactagaga tgaactccac tgcctcttta tgtcactaat    25800

aaaggataaa atgaaataac atgatttgtt aaagcatttt aaattcttgg taaggaagat    25860

atccttacat ttaaagtaca ttgtactttt caccatccag tggatagtgc cctccaggag    25920

ggctcttttg tttcatttcc cctccctggt ttacaggctt ttcactgaat ctgtttagta    25980

tttgtttatt taacaaagac tcacagaagg catcacgtag cagacatggg actaagttat    26040

acagtcttaa atgagacatt aacagtcact gacttcatgg agctttccag aataaacagt    26100

gtgactggga aagtggatga aatagctcta atgaactctg ataagaggta tttaagggag    26160

gaaactgaaa ctaatgaaga aaatgaggat tagaagtaac tttgggtttt atttacctgt    26220

tctgttccag ggcttcaacc tactccaaat cccttagctg agaaaataaa tatatacata    26280

tcattatgaa tactgtcaat ttttctcatg tatccttata gtaagtacat cttgaggaat    26340

aatattttga ggttaggaaa attctcttta acacaaaaca tccactgtca tcttcatcgt    26400

aatatttatc cttttctatt ttactttcag aaacagaaat aaacttcctg ctcaaacaag    26460

cactcacgat tgttgggact ctgccattta cttacatgtt agagaagtgg aggtggatgg    26520

tctttaaagg ggaaattccc aaagaccagt ggatgaaaaa gtggtgggag atgaagtaag    26580

tcaatgaata tgcaatcagt aaaatgtttt ctaatgagtt tgctgtgtat ttaaaagcat    26640

ttgactggcg tgtacacaca cacacagagg cacacattaa ctaactactt tttgtatttt    26700

tagtttgtta tattttatat tttagtctcc atttggatac catctcctca gataaaattt    26760

ccttgggtca ggtgacacta cttcatactc tatattctta agtattggct tactcattaa    26820

actatgatat tatgttgaaa gtgatcaatt tattcatttt acatattctt ttatccagcc    26880

ttttaaacaa aacggtgacc ccacatttta ggcaaagcac tggggatcca atgttaataa    26940

tttcaggtat ggtcctcaac cccaaaaaac gtttagttta tggcaggatg tggaaaatta    27000

aaccactgca atttgtagtg ttgtgatggg agggtacagg gtccgttagc gtccagggga    27060

gatccaaagc ccaactgggg gtgtcagatg aggagaggca tttaagccct gagaaaggtg    27120

tgggtgtaga ggggaacaca gagaattcca agctagagag aacctgacac atttgggcaa    27180

cagtgaccat ttccatggtt gcagcactac gttacttatt gctgtgtcac aagtgcctca    27240

cactgtgcct gtcacatgca agtatgaaat aaataggttt ttggaggaag gaattataag    27300

agaaaaagaa aaagaaggaa aaaaagaaag gagagaggga gggagagaat ggaaacaaga    27360

aagaaatcta tcttcttttt accatcatag accctggtca attatttctt tctttatttt    27420

tcttatattt tctttttgaa gtgaagaact catgtgtaac aagcagttcc acatgcacag    27480

gtttaaaaca gtacacttct tctgtcaaga ttctctctgt taacataaat cgtacttggg    27540

aggaaagacg cagcacctat aagaactgtt gccagtgttt aaatattact gaagttatgt    27600

ctacaatgat cctgcaattt taaaggaaaa atgtattcca tttaatcaaa gccaaataca    27660

tgattttgct accttttttt ctggttggat taatcttttg acccctctta gcttatttta    27720

aaggcacatg gaatcagatc cttagagtga ttcattaatg catcaattgt tcctttgttc    27780

agtaaatata aattaattct ttctgtagtg tcaggcacca tgtttgacac tggaattaga    27840

gagaagacca agacacagcc ccaccctcta ggagctcaag tctctagggc aggaagttac    27900

tatagttgaa taactacaaa acggggagat aaatggcaaa ggaggcacaa ctagagaagg    27960

ctaaaggaga ttgaggggtt aattctgcca gaaggtggat gggatcaggg ccaggcttca    28020

cagaggaggg aacacttgag ctaggtaggc gtggagaata agtaagattt caattttatt    28080

aaattctctc tgccaggagt acatgaagtg tggtgcctga gaggaattat tagggctttc    28140

actgtacatt tttggccatg caatgcactt tatgaatgtt attaaattag tcttttgaag    28200

acatagctat tttccaaggg tatattctgg ctgaattaat taaaactaag agataactac    28260

ataatgagct ttactgtctg attttttaaa aatttttatt tattttttat ttttgtaggt    28320

gatttttttt tacattgttt ctatttcacc caacaaccat ttctaatgta aataccattg    28380

attggctgga cacggtggca cctgtaattc cagcattttg ggaggccgag gtgggcagat    28440

cacttgaggc caggagttcg agaccagcct ggccaacatg gtgaaaccct gtctctatta    28500

aaaatacaca aattagttag atgtggtggt gcacacctat aaaccaagct acttgggagg    28560

ctgagatggg agaatcgctt gaacctggga ggcggaggtt gcagtgagcc aagatcgtgc    28620

cactgcacta cagcctgggt gacggagtga gaccctgtct caaaaaaaaa aaaaaaaaat    28680

ttgattgatg aaactgcact agttatgccc acctgcttgt gatgcttgtg atgggtgatc    28740

cacagctaat gtattgtttt cttttctccc caaaggcgag agatagttgg ggtggtggaa    28800

cctgtgcccc atgatgaaac atactgtgac cccgcatctc tgttccatgt ttctaatgat    28860

tactcattca ttcggtaaat tacagttttc ttgtttctgt ttaacttcta gggtttgtgg    28920

acagctgtgc taataacgac aaaaagtagg gataaatgaa gtgataatta taatttttct    28980

atttccaccc ataactacca agctcaatac agatgctcct tgctttacaa tggggttaca    29040

tcccaataaa ctcatcataa gttgaaaata ccttaagaat gcgctgaata cacctaacct    29100

atggtacacc aaagcatagc ctagtctacc ctaaacatgc tcagaacact cacattagcc    29160

tactgttggg caaaatcatc taacacaaac cttattttat aataaagtgt tcaatatctc    29220

atgtaattat ttaatactgt gctgaaagtg aaaaactttg ggtacttacc attaacatat    29280

acagctgaaa gcgctattgt aaagtcgaaa aatcaaaagt ccaaccgttg taagttggga    29340

actgtctgta tagatgatca atttcaattc aatttaaact aacacaattt attgggttaa    29400

attaaacttg tgtaagatct tgtccccgtc atcagcaatc aatagtatca ttgggagaaa    29460

taaaaagtag ttttgtcttc ttgttactgg cagtttattg tacattgtga tagagaattt    29520

ttaacttgaa gtccaaaaac atatgttctt cacctactaa ccccagtcct tgaatttgct    29580

ggagctcagt ttatttgtaa aatgaaaata atattatcga cctgttataa ggatggattt    29640

gcatcattta tgtgaaaggg ctattaatct gtaaaacaca aaacaaatgt tagctaacat    29700

ttaacagagt aatattgcca tgtttatcaa cagatacata aaacacaaat aggttatgat    29760

gagtgtagag ttcatgtctg gagaaagaga tttcagagat ttgatcagta tctctttggt    29820

tacttgggct ccagatttaa atatatgccc taatctataa ctctaagaca gtaagtaaac    29880

acgggactgc ttttttgttg ctttgtctcc tgtgcagata ttacacaagg accctttacc    29940

aattccagtt tcaagaagca ctttgtcaag cagctaaaca tgaaggccct ctgcacaaat    30000

gtgacatctc aaactctaca gaagctggac agaaactgtt gtaagaaata cctcaaaatg    30060

ttgaacctct cctagtattc agtattactc atttccatgc ctaggtttgt atttgatttc    30120

tttgttctaa aaagaaaatt ttatggcctc aaaatgtcct catttacaaa ccaaacattt    30180

aatttgtggt cagacaggaa cctagaccat acaacaattg ggtgggccac ctcttttctc    30240

cctatcataa ctacagccct ctcttcctgg taattggaag gaaagagcgg tttagggtgg    30300

aatatatctg ttaatatgca ttcttttctt atctgccaga agcaaattta gccaagtcaa    30360

agagaagaaa ccatagatca tagatgtaaa tatatgtaca tctggaaccc ctcaaaaggc    30420

cctgaacccc ctttttttgt gtagcaatat gctgaggctt ggaaaatcag aaccctggac    30480

cctagcattg gaaaatgttg taggagcaaa gaacatgaat gtaaggccac tgctcaacta    30540

ctttgagccc ttatttacct ggctgaaaga ccagaacaag aattcttttg tgggatggag    30600

taccgactgg agtccatgtg agtacaccca gttgacaagt ttcacaccca ttccttgtct    30660

acttcgtcta gtctcctttg gccccagtct catgaggact tgtgacacag ctgagaatgt    30720

ttctttctct atagtacctg cttctttctc tgctatggtg acagctgcca ttttatggga    30780

gaaaaatcac aactgttgag cacctatgta tgagacatag tgaaagcaac tgtacagaca    30840

aacacacaca gatgcatgca catgtgtgca tacacataca agagtgtgta ctctttcaag    30900

tctgttttat tagtctcatc tttaaaatac atattataac tgtctccaac caactgtact    30960

cgaatcctgc tttccaaaga caaatacttt ttttaaaaca attttaatgc tattatctct    31020

tctttctggc agtcactttc atatttctaa ataattttct tatattgcta ttttgttatt    31080

gctcagtttt aaaccttcgt tttggtctac tcttccactt ccatttcttg ctcttccaat    31140

aaggccttat aatgattttt agtaaaacag ttatcaatgt ttacatcact atgcctgaag    31200

agccaagtaa tgtattattt tgtgtccttt cttatgtggc ttgttgtttg tctcaaagtt    31260

tctacttgcc tgaatttttc ggcttaccta atttgctatc tacgttgtat ttgtttttct    31320

cccaaatatt tcaacatatc tattcttttc agtctcattt tttttcccta gagacttccc    31380

tcttggagtc ttatattctc ctttcccaac atttgttgtt ctcctgggtt gaatccactg    31440

cttcctagat tccatgtctt ctttcttgga ttacctcttg tttttctgga gcatagcctc    31500

ccacagactg tccaagcagg ggcacaaggg gtaggaggat caactgttct ccaaagtggt    31560

tttaaccaca ccctgacttc cattcctctt cttttcagcc cagtattatt ttcccaccct    31620

cacctgtgct tgaattccaa acctcttttg gattttttgg ctctttgtgg gtctgtgcct    31680

cctctgtgta caaattaggt catggcttcc tgtccctgag aaagcagtta cccctgtctc    31740

atcatttctc gttttccaaa agcctgttga tacctttaaa agatcccttt actatcactt    31800

tagtgggatc tttggaggaa aaggaaataa gcacatgtgg gcaatctgtt gtctgtaacc    31860

agcagtctgc tatttctctt taatcagatg cagaccaaag catcaaagtg aggataagcc    31920

taaaatcagc tcttggagat aaagcagtga gtattctgga cagtgaattg attatttttg    31980

agtgcacagt cttcacttaa ataggacaca ataaacccat ttcagtgtga actgaaagaa    32040

gagaggccat gtggttcttt tcaaaactat aagttccaga ttctggcctt tgcctttggg    32100

tttttaaagt aacctattcc ttattggata agctattcct acttcttatt gccttgaagg    32160

tgttatgaac ttcaatgaga aaatatctgt atcaatcctt aaatatcaga taccaatcct    32220

ttcaattgac tctcgtcacc attactttta ttctagaaag agaatatggt tatattttga    32280

aaggtagttt gtttttagaa gcggtacagt taggtttttt tagtttgttt tgttttagtc    32340

aatcacctgt atcctggctt cactcagagt gtggcccatg gtccagcagc atttgaatca    32400

cctggaagct tgttaaaaat gcgtaatttc aagcctagcc ctggaccact taatcagaat    32460

ctgcatttta gcaagcctcc aggtgatttg tacgtacaat caagactggg aagctctaat    32520

ttagaacact gcttctcaaa cttggctgca cagtggaatc acatgggaag tttaaaaaat    32580

attaatgcct aggttataca cctccagaga ttctgattta attgttctgg ggtatggagt    32640

caagagttgg gcatcaagag tgtttaaagc tccccaggtg attctagtca cagcaaagtt    32700

tgagaaccac ttatttaggg aaatgcattt tgggggtaac aaaatatttt acaggaaatt    32760

atgttattta caccttaatg tgaattattt acttagctat tgctctgtcg ttaacacctg    32820

tctcagatga tccagtctga ggaagtggta gctttgattg ggaaagagga gaggaaagag    32880

tagtctcggg tagatggggc tcaaaagcct gagagtgggt atgacaccct gaaggctttg    32940

cagggttaga agtcaatctg ggactattgg ataaaatggt ccaagatgct acagcaaatt    33000

gttgtctgca ttggatagat ccaaagattg tgtttctacc cccttacctt tcctgaaaag    33060

ttaaacattg tccaagattc aataacactt ttagtataat tttcatagtt aagacatcaa    33120

aacataaata actcaggagt aaaaagatga acattcaaga aagaaaaaat gaaaatggaa    33180

gtgcatttct ttccaatcat taagagttca agttcctatt tcataataat cattgggtga    33240

ttgtgggact atttctctgt catattttta ttagctcttc cttggcttaa tacattttaa    33300

ttagtctcgg cagatcagga tattttcaat tatctttttt cttgacattt atactcatcc    33360

tctttccatg cagtgagggt tggtaaatag tgttcaggga gtttgattct gtaatgttct    33420

gaggccaatt cactgagcaa caatctgttt tgatgaaacg agatcatata tttagtgcat    33480

ctacacaaca gggtcagaat atctgctcag ttcaaactat ttcatggtga attccaatgg    33540

atctatggca ttattttgag aactcagcct ttaaaatctt ttatatttta tatttataga    33600

gatagtagcc agactgttat tagtaacaat attaataata ttattactat taaaggaact    33660

cctctaaacc tcggtgaaac caagctgaag tgaatgtaac aattcttttg tgaaatatta    33720

taatttttta aagggaaagg agaaacatac aactagtgcc attcattgat tcctactgcc    33780

agctactgga ggaaagagtg aatgctttct tttaagtctt taaaagctat gcaaacataa    33840

gctatttgtt tagcactgga aaacaagaac aaacagatta gcttgctgtt tacaaagtgt    33900

tatttttcat ttgaacgtca agtttttctt ttacacttat agataagtac atttctgaga    33960

acgtaccata aaaatagtaa aaactgattt tgtccacaag gtacagacat tttgctacaa    34020

aacccacaac ttttgtttga ctcccatcgg taaacctaca ctcaaggtgt taatttcagt    34080

ttacatcaaa ctaaagtaaa aggacccgtg aacccaatgg ttcctaaagc atggttgcct    34140

gaccagcagc attaccacca cctgggagtt tgttagagat gtaaattatt gggtttcatc    34200

tcgggcttcc tgaatcagac gctctagggg tggacccagc actcagtgtt gtaactaacc    34260

cttcaggtga tacggatgca cacttacatt gaaggtcact gacttaatga atagcaagaa    34320

tctctggaat attaagaata attcttgagg agtatcagat tataaatgtg tcttacgagt    34380

ccctctgagc agtgtctttc ttctgaattt gcagtatgaa tggaacgaca atgaaatgta    34440

cctgttccga tcatctgttg catatgctat gaggcagtac tttttaaaag taaaaaatca    34500

gatgattctt tttgggtgag ttgatttgct gggttctcaa attactccaa ctaggatttc    34560

tcttactctt gagtctgagg agatactctg cctaaacttt tcttcaagtg aaattgataa    34620

aaatctccta gtaacttata cttctttggt attgtggaat ttgggtgact ccatagaggg    34680

ctgatcgtgc cttatttgac tggtaaattg caagagtatt gttcttacta aacagctgtc    34740

actctcttct cagaatgctc tcatacaccc tcagcactga aagaaaaaaa aggcagaact    34800

tcctgccttc attgacctat attctagtat gtatgttgtg tatgtgtcta tgtgtgtaat    34860

atgtaagtga aatatagagt tacaaggtac taagtgctag gagaaaaata taaaagggtc    34920

tggggagggc tggtgtgtgt gtgtgtgtgt tgggcagggg gtaggtcaat tttaaccaaa    34980

atggtcagaa aagacgtcac taatacttga acaagtatat gaagcaggag agagrgagmg    35040

agagagcgag agagcgagag agcgagagcg agagccagca atgcagacaa tggggaaagt    35100

gtctcagctg ggggaaacag caggtgcaga ccctgaggaa ggaatatcct cagcctgtta    35160

aaggaacagc aaggaggcca gtgtggctgg agcagattag aagacaagtg gagacatggc    35220

caggacgatg ttagggcata gaggaaggag ggagagacaa aaggtcatgt gggccttgaa    35280

ggccattcta aggactttgg cttttattct gagttagatg agtagtcact caagggctat    35340

gagccacatg atctacctta ttttgtgcta ggatcgcttg acagctgtga gagcacagtc    35400

ctgtcacatc atatggtaga ccccactcat taccttcatc catgggtgca acacgacgtt    35460

ttctgctggg taggaccagg ttgtgggtgt aaatccgtgt gtggtactca gccatttctg    35520

cccaccacat tgtttgccac aatcctgggc caccgattat tccttgttga ttctcctgct    35580

gttttcagtt tggaaatttt ctataattga aaaagatgtg ggttttatat aaaggcagaa    35640

caaatagtgc caaaacttga tatcacaatt tttatgtagt tgatttcatg tgctttgggc    35700

agcattaatg ttttttttga caattacatc ctctcattgt ttgccctccc ccatgtctct    35760

ctatcctgtg attctctctc taatctcctt ttcaccagca ggggaagtct tcattctctt    35820

gattgtgtcc tctgtgccac aagtgaagat gtttgttttg tttctctaca gggaggagga    35880

tgtgcgagtg gctaatttga aaccaagaat ctcctttaat ttctttgtca ctgcacctaa    35940

aaatgtgtct gatatcattc ctagaactga agttgaaaag gccatcaggt gacattttac    36000

tttcatctaa gggtgagggg gttaccaaat acaacaacaa taaccagtat tttgtgtgtt    36060

cttcctgtgt gccaagcatt attctgagtc atttacatgt gttacctcat gctacaaact    36120

ccacgtaatt ccagaaggat cccacagcag gggaataatc ttgatttgag ttccgccaga    36180

tgtaggctct tacaaaaggg aagaaaaact atagattaca tgttatcaag caagttacca    36240

ctatgggcaa ctagagctca gtcctgctgg gaaatgtgga gagactgtgt agaatgtgca    36300

cctgaattgt cccatcagag ggctgaggaa gctggggtat ttatttacca cctcccatca    36360

gttattggct gagaactgct tccaggtggc attaattccc cagcatttca gccctgcagg    36420

cagggcagat cttgtggtct gagaatgctc tctggtaaag gggagcaggt gctggttgaa    36480

gaaagtctgg ctagaactca tggaaaatag taagtgcaga agggacgtgg acaggtattg    36540

ccatcatttg ctctcaggac tttgatgtag gattcattta actgcccaaa tcctgaaaca    36600

aggtaggcaa gtacaggatt ccttacatat tgcttggcct ctatgctagg tgagggactt    36660

gcaatgaatg tttagaagaa acagtttgtc caatttgcct caattgtttc ccacaacaga    36720

cagcaggagc gaagaatgga ttgaccttgc agatggtttc ctgtcattat aaaaaggctt    36780

aatataccta ctgcttctgg gcagctcact aggtggccct ctcgagctgc gtcagagtcc    36840

tgtttaactt cggaagcaga tctaagacct gctgggcagg gtgtgcctag aaaatctggc    36900

ttggttggag tgtatgaccc aactgtgccc agagactcac tcacttcctc cagaagactt    36960

gtgtctgtct tgggaaaaac ttctggctga gatctttatg aaaaagctca gccttcctgg    37020

atactcagct gcaagctaca ggggacctca gactctctgt ttccaggatg actcttttca    37080

gatcttttct ggctgaggtt gccaggggtt acctgactaa ttctgcgttg atctctctct    37140

ctctctctgg tggactctga cctcctgacc tgggctatac ccaagggtag gaagatgaga    37200

tgccagacac tttggtcttt gatccagaat gttctccata tcattgtttt tttttttctt    37260

taaacaatct ttatcctttt gcctccataa aagtaagcca tttcccatcc cagtgctgaa    37320

gaaactggca aaggtccctt tcttatgtgc ctccccagtg ctacctccaa atgccaatac    37380

cttttatttg gaaaatatta ctatagagac ttggtcatag gacctgattc atttgtataa    37440

tagaagaggt gtatccaatt atccgtttcc attatttgat ataaagtcat tgtagatgta    37500

ctctgacaga agggaaattc ttgccaaata tgataacttt gcccttaaac acagcagtca    37560

caaatgaata aatgccaacc atttatacat ttccacactt acaactcaat tttccaatgg    37620

agctgttgat gaacctaatc tcgagataac ttcgtataat gtatgctata cgaagttata    37680

tgcatgccag tagcagcacc cacgtccacc ttctgtctag taatgtccaa cacctccctc    37740

agtccaaaca ctgctctgca tccatgtggc tcccatttat acctgaagca cttgatgggg    37800

cctcaatgtt ttactagagc ccacccccct gcaactctga gaccctctgg atttgtctgt    37860

cagtgcctca ctggggcgtt ggataatttc ttaaaaggtc aagttccctc agcagcattc    37920

tctgagcagt ctgaagatgt gtgcttttca cagttcaaat ccatgtggct gtttcaccca    37980

cctgcctggc cttgggttat ctatcaggac ctagcctaga agcaggtgtg tggcacttaa    38040

cacctaagct gagtgactaa ctgaacactc aagtggatgc catctttgtc acttcttgac    38100

tgtgacacaa gcaactcctg atgccaaagc cctgcccacc cctctcatgc ccatatttgg    38160

acatggtaca ggtcctcact ggccatggtc tgtgaggtcc tggtcctctt tgacttcata    38220

attcctaggg gccactagta tctataagag gaagagggtg ctggctccca ggccacagcc    38280

cacaaaattc cacctgctca caggttggct ggctcgaccc aggtggtgtc ccctgctctg    38340

agccagctcc cggccaagcc agcaccatgg gaacccccaa gaagaagagg aaggtgcgta    38400

ccgatttaaa ttccaattta ctgaccgtac accaaaattt gcctgcatta ccggtcgatg    38460

caacgagtga tgaggttcgc aagaacctga tggacatgtt cagggatcgc caggcgtttt    38520

ctgagcatac ctggaaaatg cttctgtccg tttgccggtc gtgggcggca tggtgcaagt    38580

tgaataaccg gaaatggttt cccgcagaac ctgaagatgt tcgcgattat cttctatatc    38640

ttcaggcgcg cggtctggca gtaaaaacta tccagcaaca tttgggccag ctaaacatgc    38700

ttcatcgtcg gtccgggctg ccacgaccaa gtgacagcaa tgctgtttca ctggttatgc    38760

ggcggatccg aaaagaaaac gttgatgccg gtgaacgtgc aaaacaggta aatataaaat    38820

ttttaagtgt ataatgatgt taaactactg attctaattg tttgtgtatt ttaggctcta    38880

gcgttcgaac gcactgattt cgaccaggtt cgttcactca tggaaaatag cgatcgctgc    38940

caggatatac gtaatctggc atttctgggg attgcttata acaccctgtt acgtatagcc    39000

gaaattgcca ggatcagggt taaagatatc tcacgtactg acggtgggag aatgttaatc    39060

catattggca gaacgaaaac gctggttagc accgcaggtg tagagaaggc acttagcctg    39120

ggggtaacta aactggtcga gcgatggatt tccgtctctg gtgtagctga tgatccgaat    39180

aactacctgt tttgccgggt cagaaaaaat ggtgttgccg cgccatctgc caccagccag    39240

ctatcaactc gcgccctgga agggattttt gaagcaactc atcgattgat ttacggcgct    39300

aaggatgact ctggtcagag atacctggcc tggtctggac acagtgcccg tgtcggagcc    39360

gcgcgagata tggcccgcgc tggagtttca ataccggaga tcatgcaagc tggtggctgg    39420

accaatgtaa atattgtcat gaactatatc cgtaacctgg atagtgaaac aggggcaatg    39480

gtgcgcctgc tggaagatgg cgattaggcg gccggccgct aatcagccat accacatttg    39540

tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa    39600

tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca    39660

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt    39720

ccaaactcat caatgtatct tatcatgtct ggatcccccg gctagagttt aaacactaga    39780

actagtggat cccccgggat catggcctcc gcgccgggtt ttggcgcctc ccgcgggcgc    39840

ccccctcctc acggcgagcg ctgccacgtc agacgaaggg cgcagcgagc gtcctgatcc    39900

ttccgcccgg acgctcagga cagcggcccg ctgctcataa gactcggcct tagaacccca    39960

gtatcagcag aaggacattt taggacggga cttgggtgac tctagggcac tggttttctt    40020

tccagagagc ggaacaggcg aggaaaagta gtcccttctc ggcgattctg cggagggatc    40080

tccgtggggc ggtgaacgcc gatgattata taaggacgcg ccgggtgtgg cacagctagt    40140

tccgtcgcag ccgggatttg ggtcgcggtt cttgtttgtg gatcgctgtg atcgtcactt    40200

ggtgagtagc gggctgctgg gctggccggg gctttcgtgg ccgccgggcc gctcggtggg    40260

acggaagcgt gtggagagac cgccaagggc tgtagtctgg gtccgcgagc aaggttgccc    40320

tgaactgggg gttgggggga gcgcagcaaa atggcggctg ttcccgagtc ttgaatggaa    40380

gacgcttgtg aggcgggctg tgaggtcgtt gaaacaaggt ggggggcatg gtgggcggca    40440

agaacccaag gtcttgaggc cttcgctaat gcgggaaagc tcttattcgg gtgagatggg    40500

ctggggcacc atctggggac cctgacgtga agtttgtcac tgactggaga actcggtttg    40560

tcgtctgttg cgggggcggc agttatggcg gtgccgttgg gcagtgcacc cgtacctttg    40620

ggagcgcgcg ccctcgtcgt gtcgtgacgt cacccgttct gttggcttat aatgcagggt    40680

ggggccacct gccggtaggt gtgcggtagg cttttctccg tcgcaggacg cagggttcgg    40740

gcctagggta ggctctcctg aatcgacagg cgccggacct ctggtgaggg gagggataag    40800

tgaggcgtca gtttctttgg tcggttttat gtacctatct tcttaagtag ctgaagctcc    40860

ggttttgaac tatgcgctcg gggttggcga gtgtgttttg tgaagttttt taggcacctt    40920

ttgaaatgta atcatttggg tcaatatgta attttcagtg ttagactagt aaattgtccg    40980

ctaaattctg gccgtttttg gcttttttgt tagacgtgtt gacaattaat catcggcata    41040

gtatatcggc atagtataat acgacaaggt gaggaactaa accatgggat cggccattga    41100

acaagatgga ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga    41160

ctgggcacaa cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg    41220

gcgcccggtt ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaggacga    41280

ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt    41340

tgtcactgaa gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct    41400

gtcatctcac cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct    41460

gcatacgctt gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg    41520

agcacgtact cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca    41580

ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg acggcgatga    41640

tctcgtcgtg acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt    41700

ttctggattc atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt    41760

ggctacccgt gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct    41820

ttacggtatc gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt    41880

cttctgaggg gatccgctgt aagtctgcag aaattgatga tctattaaac aataaagatg    41940

tccactaaaa tggaagtttt tcctgtcata ctttgttaag aagggtgaga acagagtacc    42000

tacattttga atggaaggat tggagctacg ggggtggggg tggggtggga ttagataaat    42060

gcctgctctt tactgaaggc tctttactat tgctttatga taatgtttca tagttggata    42120

tcataattta aacaagcaaa accaaattaa gggccagctc attcctccca ctcatgatct    42180

atagatctat agatctctcg tgggatcatt gtttttctct tgattcccac tttgtggttc    42240

taagtactgt ggtttccaaa tgtgtcagtt tcatagcctg aagaacgaga tcagcagcct    42300

ctgttccaca tacacttcat tctcagtatt gttttgccaa gttctaattc catcagacct    42360

cgacctgcag cccctagata acttcgtata atgtatgcta tacgaagtta tgctaggtaa    42420

ctataacggt cctaaggtag cgagctagcc taggttgcaa ggcatgaaag atgcataatt    42480

gtcaaagact tatatcttta attagaccta tttactttgc tcttatgatt ttaggtgtat    42540

attccttttt tttttttttg aaacagagtc ttgctctgtc acctaggcta gagggcagtg    42600

gcacaatctc ggctcactgc aacctctgcc tcccgggttc aagcgattct cctgcctcag    42660

cctcccaagt agctgggact acagacatgc gccaccatgc ctggctaggt gtatattctt    42720

atgataagct ctattatatc ctttcaggaa caatgatata aacagtaaat aactacacac    42780

aattttattt tgtctaagtg tcccctttgc tgttttttgc ttttgcaaat aggatgtccc    42840

ggagccgtat caatgatgct ttccgtctga atgacaacag cctagagttt ctggggatac    42900

agccaacact tggacctcct aaccagcccc ctgtttccat atggctgatt atttttggtg    42960

ttgtgatggc actggtagtg gttggcatca tcatcctgat tgtcactggg atcaaaggtc    43020

gaaagaagtg agtatccttt cctagattta tctgtctttt tagaatgcat gaattggaaa    43080

ttttgcaaca aataacactg tatccacaca ggataattac ttacttggac atttatctcc    43140

ctaaatattc tgatatatcc catagaatct tgtcagatgc tagcagtacc ttaccttact    43200

agcaagctca catattatag atgtctagcc tgaggtttat tgggatgctg tagtcaagtg    43260

catcctatcc acagtggcat agccagactg caaactcagt aaggcattgt tctcactcat    43320

gactcttgct tcatccacag agactgacat ggagcacaaa gtgtaatgtc atctaagaat    43380

gaggtgcttc aaactactac tctttagtta ctttcattcc tccttgggaa actcaaattt    43440

atcatttgag ttcatgggca ggcacccttt aatttgttct agagctgagt tgattgaggg    43500

ctttaatcac cagggactga cttctagctc ctgtcttgag aaagtattaa ctcttgttgg    43560

tctgttcaaa taacttagta ttttgtatca ctctgacaac attatctgca tgttttcagt    43620

tgtttaaaca tactctcagt tgaatcttta cacaaattag tttattttat ttaattttct    43680

ttactataga gatctctcga ttctaccaaa taacttcatt tgaaaaagca aggctgtgga    43740

gatgggtaaa atcacctgcc ccacaagcat gaggacctga ctttgaatcc ccagagccca    43800

tatataaagc agatacagga ggcaagcatc tataatccca gcactcctcc agggagatgg    43860

aaggcagagg caggaaagtc cccagaagtc tgtaggccac tcagcctggt gtacacagca    43920

gaggcaacag accccatctc aatcacaatg ggtgttgaga atcaacactg gatattgctg    43980

tctgatcccc acgtgtgcaa tgtagcatac acacttacac acatgcacat gtgtacgcat    44040

acacagatgt gcacaaagca ctttctaggt agtgcagtca acatggttac aatgttcaaa    44100

aatacaaggg ggtcatagag ttccgttacc attctttgtt tctgagtttc cttttaacca    44160

aagttatcag tttttagtaa aatgaactat gcactacata ttcttattta ccaactagta    44220

tgttttagag gtatttccag atttttcaaa aaattcccaa gcaatatatt ttagagattc    44280

tttcagattg gctatgtaaa gcacttccat ttgcctggta atgtagttgc ccactttgta    44340

gcaaatgggt actcccatgg ttaccaaatg tttgtgtcta tttaaaaaat acaacaattt    44400

caaataggca atttcctgtg catgctaaag taggtgcaag atatgtccca gcaggtaaaa    44460

ggctaggtta aaatcatcat gaattctaat tttaattaat acttctgaac tgttctcata    44520

ggggcagaat taatgtacaa acagcaccag cttatgaaag ctctcctttt ctccaactca    44580

gcatccttag cacagggtgc catcagactt tttgacagtt atcctttggg tcagtgtaag    44640

taagtgtctt tctaccatca ctttaataag gagactttgt tttatttgac aggaaaaatg    44700

aaacaaaaag agaagagaac ccttatgact cgatggacat tggaaaagga gaaagcaatg    44760

caggattcca aaacagtgat gatgctcaga cttcctttta gcaaagcact tgtcatcttc    44820

ctgtatgtaa atgctaactt catagtacac aaaatatgag agtatacaca tgtcattagc    44880

tatcaaaact atgatctgtt cagtaaacgt tgtccaaaga gcatcagact tgagtggaca    44940

tcttcactga cattgctttc agtatttatt tctgcctaag gatttgacat ctcttctgtt    45000

tattaataga gatgtttatc ttagcataaa agagggaaat gtgcctttgg cctcacagtc    45060

tatccagggt gatatggttg ggtaactgga gttagaagat gagatgatgt ctcttggggg    45120

caagtgttgg cttcggtgtg gcatctgggc tgtgaactgg tgggactgtt gaggttgaga    45180

atggtgctcg ctggtcactt gaatccaagt gtgacgtcat gctctgtggc ttctgccttc    45240

acacttctca cttcaagtac tgtaggaatt tgttcacagt aatacttgaa atggactgtc    45300

ccttctttgg aggtgcagtt caacggagaa agaagccaga catcaggtag agaccatgac    45360

cttttctctt ccaaacttga tcaacatctc tctaacaaga cacagctagc acaggaaact    45420

ccacgaaccc agagcatgcc tgtcagaaac tacttccatt attctcccat tgtggagtaa    45480

gggaaaattc cagatgaatg ctcgatctgt gagatgggtg cccagtctct gaaattgttt    45540

gtattttctc acagggtctg agcaatggtg aacacaaagc cgacctcaat aaatacttat    45600

tagatttaga cactcctct                                                 45619


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878mTU Fwd

<400>  6
cccagatggc taaattcaat tga                                               23


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878mTU Probe (MBG)

<400>  7
ttcatctgga aaattg                                                       16


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878mTU Rev

<400>  8
ggaatctggg caaataattc attc                                              24


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878mTD Fwd

<400>  9
gggccgcatc aatgatgtc                                                    19


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878mTD Probe (BHQ)

<400>  10
tggcctgaat gataacagcc tgga                                              24


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878mTD Rev

<400>  11
gtggctcaag tgttgggtga atc                                               23


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878hTU Fwd

<400>  12
gtgaggctgg acttgggaat                                                   20


<210>  13
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878hTU Probe BHQ

<400>  13
cctttcctct ttgtcacaga cctcca                                            26


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878hTU Rev

<400>  14
ggagggctct gcctggatt                                                    19


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878hTD Fwd

<400>  15
gcaaaggtcc ctttcttatg tgc                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878hTD Probe (BHQ)

<400>  16
cccagtgcta cctccaaatg cca                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878hTD Rev

<400>  17
caggtcctat gaccaagtct cta                                               23


<210>  18
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878 5'mouse/5'human

<400>  18
aagatgtcca gctcctcctg gctccttctc agccttgttg ctgttactac tgctcagtcc       60

accattgagg aacaggccaa gacatttttg gacaagttta accacgaagc cgaagacctg      120


<210>  19
<211>  160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878 human//xho//loxP

<400>  19
catttataca tttccacact tacaactcaa ttttccaatg gagctgttga tgaacctaat       60

ctcgagataa cttcgtataa tgtatgctat acgaagttat atgcatgcca gtagcagcac      120

ccacgtccac cttctgtcta gtaatgtcca acacctccct                            160


<210>  20
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878 (loxP)/ICEUI//NheI//human

<400>  20
cattctcagt attgttttgc caagttctaa ttccatcaga cctcgacctg cagcccctag       60

ataacttcgt ataatgtatg ctatacgaag ttatgctagg taactataac ggtcctaagg      120

tagcgagcta gcctaggttg caaggcatga aagatgcata attgtcaaag acttatatct      180

ttaattagac ct                                                          192


<210>  21
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7878 3'mouse/3'human

<400>  21
agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc       60

atatggctga ttatttttgg tgttgtgatg gcactggtag tggttggcat catcatcctg      120


<210>  22
<211>  40887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7679 allele


<220>
<221>  misc_feature
<222>  (1)..(1377)
<223>  Mouse sequence

<220>
<221>  misc_feature
<222>  (1378)..(37630)
<223>  Human sequence

<220>
<221>  misc_feature
<222>  (37631)..(37636)
<223>  XhoI

<220>
<221>  misc_feature
<222>  (37637)..(37670)
<223>  LoxP

<220>
<221>  misc_feature
<222>  (37677)..(37702)
<223>  Iceu1

<220>
<221>  misc_feature
<222>  (37703)..(37708)
<223>  NheI

<220>
<221>  misc_feature
<222>  (37709)..(38198)
<223>  Human sequence

<220>
<221>  misc_feature
<222>  (38199)..(40878)
<223>  Mouse Sequence

<400>  22
aggcccatga gccctgccat ttaaagtggc tcctctctta cactctggga atgaggacac       60

ggagccagct gctgaacttc accaggataa ccattaaaat tgctttggag ttcatatttc      120

cacgatccca tgcctatgga tgccaaggac ttgtcatgga tgcgctttgg atttcataat      180

gcagagtcat tattacttcc ttgagttctc agctgagttg taagcaggta agtgaaaggg      240

aaagaggcac ctgataaagt cagctgtagg actagagttt agcatgtctc ctgagaaata      300

gaaaatgact gcttgaaact ttaccaaagc cacacaggaa gcatcaaact ccctatggag      360

tggagaagag tcttataatt ttttaaatgg gcagagaaat gaatttattt ttaattttta      420

gagacagggt ttctttgtat agctctagct gtctttgatt ggtagacaaa gctgtcctca      480

aactcagaga tcttccttcc tttgtctcct gagtgctggg attaaaggca tggaccacca      540

ctgccctgcc ccattctctc cattaatttt aagtgaatgc ttgcaaaagc tcacttcttt      600

ggtgaacagc ttcctttaca aataagtacc tttgccttcg tttttatagg attcttaaaa      660

agaaaaaaaa gattcagcca ggtggttgtg gtgcacacct ttaatcccag cagtcaggag      720

gcagaggaaa gcagatctct tgagtttgag gctagcctag tctacagagg gagttccagg      780

acagccaagg ctacagagag gaactgtcta aaaacaccaa gaaagagaga aaggagagag      840

ggagaggatg gatagcttat tgatagaatt gtcagaaaag gctataagtt ccaatatgtg      900

tcccatgatt tctaagtcta gccctttctg ttatagtaaa atcatagtac accctcctcc      960

tccagtgtat ctttaacagc ttttaaggaa catattaact aaatgtccag gttttgattt     1020

ggccataaaa tgttagcaaa gctaaggttt tctaggatta atgaataaca tgtctttatt     1080

tagtttactt aaaaaaatca ttctaaaata tctgtttaca tatctgtcct ctccaggatt     1140

aacttcatat tggtccagca gcttgtttac tgttctcttc tgtttcttct tctgcttttt     1200

ttttcttctc ttctcagtgc ccaacccaag ttcaaaggct gatgagagag aaaaactcat     1260

gaagagattt tactctaggg aaagttgctc agtggatggg atcttggcgc acggggaaag     1320

atgtccagct cctcctggct ccttctcagc cttgttgctg ttactactgc tcagtccacc     1380

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc     1440

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa     1500

aacatggtga gttctcatgg ctctattggg ctatttgttg cctcttaaag attagattac     1560

tgcccgtgaa actgaaaagg gaaatcaaaa aaaatgctct gagttgtgag attggatgtt     1620

tgcctccata tccctgattt tggcgtcgac gataactaaa cttaattgac cctggggttc     1680

attcagaaaa ttgttacaaa ataattcact ggtctcaatc cagatgcttg gaaacaagag     1740

aatattcttt ataaagttac caccataatt ctcatcacag tcaggatttc aaagcatttc     1800

atggaaatgc cataagttat tgagttaata atttccttta gcctacaata tcaataggaa     1860

tatctaaaga ttctctacaa atgatatatt aactgaaaaa tgcaactgga ggcttagtga     1920

aagaactagt aattaagcta atcagggctt gggtgaggct ggacttggga attcctttcc     1980

tctttgtcac agacctccaa gggactccaa aaggtcacag aatccaggca gagccctcca     2040

aaacaaaaac aaaaacaaac aacaaaaaaa ctatgattaa accagttctg acaaatatca     2100

gaatgctctg ggaaagccag atgctttaac aagtgcaagg atttaggaat ttcttctctc     2160

acagatccca aaacagtatc cttaagtggt gatccttatg tcaagctgtg agaatatacc     2220

tcaaaataat agaaggcatc caaacttgat cagtatagtg tcataaagct gctgatgtag     2280

aagtgtggag aggtccatca gatagagata tggaaaaaaa agcttggtta aaacaggttt     2340

ccaaagttct ctccctttct ctgccattgt ggtatgtgtg gttgaccatt tctcatcatg     2400

ttttcttaca agactttcag gatcaagcaa ttcctcgcca aaaaacaaaa tcaaggacac     2460

gttgtagcta tttcttggtg agttaccaga agctgtgaag agagagcatg aggcccatac     2520

tttttttttt ttttgaaggg tctcgctctg ttgcccaggc tggaatggag tggcatgatc     2580

atgattcatt gcagcttgac ctcctgggct caaatgattc tctcgcatca tttaacattt     2640

ttttttgtag agatgagatc tcactttgtc tcccaggctg gtcttgaact cctgggctca     2700

agtgatcctc ttgcctcagg ctcccaaagt gctgggatga caggcatgag ccactgcacc     2760

tagcctacca cacttactct ttgcgtggtc tctagagctt cttcagcccc cctgctgcca     2820

gggtccctag ggtcttgggc atgccccatt tctgaaccta ttcctgtctc cagggataga     2880

gtcacagtga actcagacca gggtaattct aaactgctat tctgtatata cccaaggaaa     2940

tttcatccct gtctctaatg agtctgtccc atgcccctta atacacatga acacctacac     3000

acaggtacaa gtcggggaag atcactgtgc agcacataaa ataaaattca ggggcgagca     3060

ctttttttcc catgagataa agttaggaaa aaataaaaat gttcatacag attaaaaatt     3120

ttaaatgtta aaatattaaa cccccaatct aaaataaaga aaaaataatt tcttaaatcc     3180

taagcttgag ttatggaatt cacattctta taatttacat tacctatttt gttaaatgga     3240

agactttttt ttttaatatg caagtacctg ggcatattta gaaagtaacc aaggcagctt     3300

ttgtctttga acctgatgcg gttttgacag ctctatctgg aaattgagcc agcatatggg     3360

agccaagggt gaaagttttc ctgggagatt tgggctccaa ggtactggat agatgctaaa     3420

gattccattc agtttttcat tttctgtctt catggaactc tcacacctac aggggaagaa     3480

atggtttaga ggttactaaa agtatatagc ctggtttagg tgatagtgag ctatagaaaa     3540

agagaaaata agttgtcagt actttaaatc tcaaacaact tcttacaaaa ggattttaat     3600

agtttaaata caattatcac aagttgggta aagacaacca gacctatggc ctgataaatc     3660

atgtatttaa tttatgcata tagttagggc caaaaagagc agagtatctt tttgaatgtt     3720

ttaaaatata atctaggatt ttatgcctac agtccttgaa attacaaagg atctctctca     3780

agttgggaat atgctatcca ttgcagttac ggatgggatt tagagactgt tttaatttct     3840

tgtgattatc tcaaacaacg tgttccttac tcccaaaact cccttgtatg gctacagaaa     3900

ctgttgcagt tttagttgct tctcccctgc ctttgcccag aggtagtgtg gaatgccacc     3960

aattttatct gtaatggttc ctttcaagcc tggggctatg taagctgcta tatatgcttc     4020

attccattca tcattcagtc taaatatagc tatcaaccac taaattatct gataggtatg     4080

catgaactga ctgattcttt gcataactac taagctatct gttttattta ggcttgggag     4140

ccctagggta aggatacgga ataaattgta aatgatatta aaagaatagc ttggcaagga     4200

ataatacctc ctcaggggcc aaaatgcaag gcaacacaaa gtgatttttt tggtgatata     4260

attataacac atgtagtatg gtagtgataa ctaaaataaa attggatagc ctcaaaattc     4320

ctacatgtag tatgataaac aatgttctaa gactgaggcc tttgggaggt agtgagttat     4380

ttcctataga tagagagtaa aattattcct ataatttggt atgaaagttt taccagaaat     4440

tttgcttcac agtaaatcat ctggattggg tgaagccagg tagggattga gaagtgagtc     4500

aggtgggttg catagatgag tttgtgctgc agaccaaact cctcttccca tagctcactt     4560

cttcccactc ctgcatgtta gagagaagac tagaatgtgt caaatacaac ctataggata     4620

atagttcaga gcattagctt cggaagtaaa cactaggttg atgccctggt tcttctaatt     4680

tctagctgtg tgacctaggg aaagttacct gctgtgtgcc tcatttccct tatttgtaaa     4740

gttgagacaa taacaactcc ctcacaaggt tgttgtgaag attaatgaaa aagcagtttc     4800

tgagaggttg tgagtgttca gtaaagaaag aaattgcttt cctttttttt tttttttgag     4860

acagattctc attctgtcat tcaggctgga gtgcagtggc gcgatcatgg ctcactgcgc     4920

ctcgacttcc ccaagctcag gcaatcttcc cacctcagcc tcctgagtag ctgggactac     4980

aggtgcgagc caccacacct ggctagtttt tgtattattt gcagagatgg ggtctcgcct     5040

tgttgcccag gcttgtctca aacttctggg ctcaagcgat cttcccacct caacctccca     5100

aagtgctggg attacaggca tgaaccacta cacacagcct attttccatt ttcactgcca     5160

ttattttctc tgtctcttgt gtggctcatt actgccactt ctgtgcacca tttccatcat     5220

gtcacatgcg tagtcaaaac cctcagtgac tgcctaattc tcagagggta aaagtgaaat     5280

tccttggcct ggaaagtgca atcatgcctg aagttctacc tgtgggagct gtactagtta     5340

tctattgtgt aaaaagttac cacaagctta gcagattaaa acaacacata tttaatatcc     5400

cacagtatct gtgggctagg agtccaggca cagttcagct ggatcttctg cttctaagtc     5460

tcatatggtt gcattcaagg tgctggctag agctatggtc tcttctgagg cttgactggg     5520

gatggatata cttccaagcc aatgcaatta ctcagaggcc gtctttaatt atttgccatg     5580

tggccttttc catagggtag ctcacaacgt ggcatcttgc tgcaacaagt cagcaaagga     5640

gagagtcttc tatcaagatt aaagttaaaa tcttatgtaa cgtaaacatg acatcctgtc     5700

acctgtgttg tatgctattg gttgaaagta aatcacgggt ctgctcatac ttatggggag     5760

gggatcacac aagggtgtga ccaccaaagg cagagatcat gggagcattc ttagagtctg     5820

tctgccacag ggccaggatc aaatgctggt ggctgattgc cagctccact gtttatttct     5880

ctcagccgct ttctgtatgt acaaaaaagg agagagagtg attttctacc tcatagtgtt     5940

gttaagaaaa tcaaatgagg taaattattt tgcaaagtat tctctactca tctgactcct     6000

acctactttc aggtctgtct taagttgcaa cttctgcatg agggcttggc caagtatggt     6060

cacctgcatg aatttcctct ttcttgtaac agaaactgct tggcccactc ataatttata     6120

cattattata tactcttatg tttcattaat gaaacattta taatgcatat cttatctgtc     6180

tgataaaatg gaaagcaatc taaggacaat gacttttccc ctatacataa caaaatataa     6240

aataaatcat aacataataa ataataaata aataataaaa taactaacat ttgttgaatg     6300

attaggatgt gttaggcact cttgtaagca tttcattttt ttgttacttc ttcaaatcct     6360

tacaacagtc cttggaggta agtcctatta ttactttcat tttgcagata agacaactgt     6420

ggctcagaga ggctaaggta cttgagtcca ggagcagaat tcttactttc ctcaaacgtt     6480

atctcttttg tgtggtctag ggcagtacaa tataccaagt agttgctcat tttggtcttt     6540

ggtaaatgga aatgaatttg taagttgaga aaagactaca ctacagtagt ttggagaagt     6600

ccactttcca actgatgttc aagattcagg agggggggaa atgtgtcctg gcatcatcac     6660

ttgcttgatg atttcttttg ctggtagaaa atcaccatgg ctaccaatgg ccattttctg     6720

ggaagccttt tttgggaatc ctaacttaag atcaaaatcc ctgggctaag tcacggcagc     6780

taggaggtta ctgtgaaccg gttctcattt cttatggttt ccattgttat tagggggctg     6840

tattctcatt aagtccactc tgagctctac tggattctct ttttagagca ctcgtctttg     6900

aattcttggc caactcatct atgtcacagc actaaggcta taaattccag ggccccacaa     6960

tgtggattat ctgtgagaat tcatttccag ttctggggac aagacccttg ggaaaaccag     7020

gcaataggcc agagagagac agagagagag agagtggtca aaagtggcct ggtcactctt     7080

aacctaaacc ttgaccttca gcggagtaga ggactaaatc actcaggaaa tattaaatgt     7140

ttcaccagat attatttgga ctatatcttc tgttctatct cttcaagcaa tgccattcca     7200

acttcaattt tcttttctgt catttcagaa taatgctggg gacaaatggt ctgccttttt     7260

aaaggaacag tccacacttg cccaaatgta tccactacaa gaaattcaga atctcacagt     7320

caagcttcag ctgcaggctc ttcagcaaaa tgggtcttca gtgctctcag aagacaagag     7380

caaacgggta cgtttgtgaa cattttagca ttgatcccaa gagttgaaat atttgggaaa     7440

tattaaacat taatatcacc cacagcagct gcctttattt gaaaaaatag taatgctgat     7500

gttagaaaaa tctctctcta tgcctaggta aggtgtccat ataatttatt attcaaactg     7560

gaatctttga gagtgaaaga cactggtaat tattatattc aaacacagag ttaaactgag     7620

attgtccctg gcactgtggt gtgtatggac accccctagt gttaggtcac cttcctgaag     7680

gatcaggcag cctgaagaat acagttagtt tatgtcagtg gttctcaact gggggtgatt     7740

tagccctccg gggatatttg acaatgtctg gagacgtttt tggttgccac aaatggggat     7800

actgttgaca tctagtgggt agggatgctg cagaacattt cacaatgcat gggatggccc     7860

ccaacaacaa agaatgatct tgtccacaat gtcaacagca aacttttttt tctgtaaagg     7920

aacagatgac agtaaatatt ttaggttttg tgtatttagg tattgtctgt gttgcaacta     7980

gtcaactgtg ctgttgtatc aggaaatcag ctgtagctaa tatataaatg aacaagtatg     8040

gctgtgttca aataaaactt tacaaaaaca ggcagcagac aggatttggt ctgcagaaca     8100

cagtttgcag acctctgata tagcctattg aaatattttt aacctaaaat atttagctat     8160

ttaaaaagaa agtcttcttt ctcagttgct tgtcctctgg aactttgtat gttctaatct     8220

gtgaatataa aaataaaaat gcatcaaaaa ggcaaagata aaaccatgtg aaatgtatct     8280

ttctacaagt taacatttat ttttctgcat tctttgggtc caattatcca actaattatc     8340

aatgcacttt actttatcca ttctatgttt ctccattttt tcccccaaca aggacactat     8400

aagaaacctt gcccattcgc atatagacaa tctggtctag cctaggtgga acctagaaat     8460

tctatttttt aaaaaatccc cagataattc taatgtgtag ccaggactga aaaccactga     8520

aatgcatgta agagcttaaa gtgtttggga agaggaggga ctcaaggttg cttagatttg     8580

atggagagga agccgtggag attgaagaag agctggagag agaccatgag gggttttgtg     8640

ccatggtaag gaatttaggt ttgttccttt ggactatggg atcgtgtgga agttttaaac     8700

ataggatcta tttcatgttt taggatgact ctcaaggcag aaccaaaggg aaataggaga     8760

aggagaaaca gatcctttaa tccagtgctt cttaaatcaa tctgagggag agaaccattt     8820

ccttccttcc ttccttcctt tcttctcttc ttccttccct ccttctctcc tccctcccgt     8880

ctttcctttc tccctccttt attcctttat ttccaataca ttgcagatca atacttgctt     8940

aagttcattg attacatgct tagatgtcat ggaaatatca aattgttctc caaagtttat     9000

aaacttttat tctcttaatt cctgtactta tcacagaatg gaaacaaact gtcacttgca     9060

ctggtccacg gattacacct ggagtagcac tgcttcacta tatcaccttc actttatctg     9120

cagggtaaag tttaaaaact ttggtatggc atagacggtc cctcgtgatc tggcccctgc     9180

ttgtctctcc attctcatgt ctttcatttc ccctaatgaa caccattgct ccagtttcat     9240

tcaacatctc actgtcccct gagaatgcct tgtcttttcc aacctccttc catcttttag     9300

actcttccct ctacctccct tctctacatg accagtgcct acttcttctc caagacacag     9360

ctcttatctt cccttctctt tggacccatt cttgaatctc ctggttatta gttattaatt     9420

tctccctgct cctatactac cgcatcactt tttggtgaca gttatagcac ttgtcattct     9480

gttatgtatt aatagttatt gatttcatgg ctgcctcact gtcctatgac tttatggtct     9540

ttgacttgtt cacttcagaa ttgtcagagt gtaggacata ttccaggttc aataaatgct     9600

gaatgaaaca aaaaatgcac ctctctgtgt atgtgtggat aagaaaactt ctttgggttt     9660

tggtagatct ggttatttca attactccat atatatttat tatgtgctta tagtactttg     9720

tgctagtcga cagtggggaa acttaactgg gctattcctt ctccacatac agaaagatac     9780

atggcaaaga agtaaattgc tgtattttga gtaatcaaaa aatcatgtgg tcaaaaggat     9840

atctttatat tagcattctc ttcagcaaaa tttccattgt taacattgtt tattatcttt     9900

aatttgcagt tgaacacaat tctaaataca atgagcacca tctacagtac tggaaaagtt     9960

tgtaacccag ataatccaca agaatgctta ttacttgaac caggtaggct actaattttt    10020

agtagtgatt atgaaattta cttttctctc agattttaaa aatgattgca gatatgtgtg    10080

tttcaacaca tagatgctct tttaactttt agtaaaactt tcttgtaaat tgtatcacat    10140

ttacttaatt tgatcaagtc agtaagtaag tcatttcagt ggtttatttt ctctgcagac    10200

atattttgga actataaggg caaggacatg aatgaatcat gagattttat ttaaccactt    10260

tatgacctga tgtctgccaa ccttactttt aattctttaa agttcatgta gttctttaca    10320

aataaaattt ttacaaaggc atcttttctt gtctttgtgt gctttgggat aacaggtttg    10380

aatgaaataa tggcaaacag tttagactac aatgagaggc tctgggcttg ggaaagctgg    10440

agatctgagg tcggcaagca gctgaggcca ttatatgaag agtatgtggt cttgaaaaat    10500

gagatggcaa gagcaaatcg taagtttgct gatctgtaga ggtcctgaag ctctctgtgt    10560

ggccacgggg ctatttcttc tgcattacca agcctgccct ttgatatcag ggatacccct    10620

caattaacaa tcatgtcctc aacaattcag attacctgtt ttcaaaagaa attactgggg    10680

aaaaagaaaa ggtgcactgg cattctacaa ttcaagaagc tcaagaatga gactcaacta    10740

caaggcctaa agtaaattat ccaggaatta tgaattataa gtaatctagg aagatctcag    10800

gcccctaaaa gttcccgagg gagtctgggg attaaggggg ggaatcccat ttctcaggat    10860

gaaagacaga gtcactgcct tttgtctaaa gcccccacag ttcactttca aaggtcattt    10920

gtgtgtctac cttagggtga taccccagaa agaaaaaata tcagattagt ttaggctgga    10980

aatgtattat tttctgcagt tgtaattata tctcagatta tgtggtcata aaaaatctta    11040

acataggaag gaatttccat atctcttaac ttattctctt ccctgaatag tgagctgaag    11100

tcatggaatc atgattcaca ttttgctttg atgatttact gcccactgag gttgagtaag    11160

gaagaatttt tttcccgcat ttgttgtttt aacatttctt tcactgccac ttaaattcag    11220

tattcttaag ccttaggcaa gctggagaca atagcttatc accattttta aaacaatatc    11280

ctgcatgtcc tttcatccaa atatttattt ctctcctcat cttcctgatc attaattgcc    11340

aatgtgaatg taaaaataaa aattattaaa ttatgtttac aaactttatt agctaatatc    11400

ctaacacaag cttgtgtttt ctgatggtga gatactaaag gaagcacata gaaacatgct    11460

attgatacat ataatttgca aacaaacaca ggttcactgt ggcaaagtct aagatgagtt    11520

gggtctgatc taaaaataaa aggccatgaa caaaagaaga atttaaaaac ttagagatcc    11580

agtcacatat tttaaagcta aagatacaaa ctgatgtatc aagagagtac acacccaggg    11640

ttaagagact aggaatgtgc ttctttcgct taccagctgt gtgatcttgg acaagtgatt    11700

taaccactct aagcacaggt tgttggtggg aatataaact ggtgaagctg ttatggaaaa    11760

atagtatgag gattcctaaa taaattaaaa atagaattac cgtatgatcc agcaatccct    11820

cttctgggta tatacctaaa ttagatgaaa ttaccccttc ataaagatat ctacactgcc    11880

atgttcactg cagcattatt cgcaatagcc aagataggga aacaacctaa gtgtttgtca    11940

agggatgaat gaataaagaa accgtggtag gtatatggaa tgggatatta ttcagcctta    12000

aaaaagagga gatcctgtca tttgcctcaa catggataga cctggaggac attatgctaa    12060

gtgaaataat ccagacataa aaagaaaaat atggcatcat ctcactcaaa agtggattct    12120

acaaaaaaat caaatataca gagatagagt aatagtgatt accaggggtg aggtggagcg    12180

gggtgggata tggggagaag tgggttaaag gatacaaagt agcagatatg caggatgaac    12240

aagtctaaag atctaatgta caacataagg actgtagtta gtaataatgt tttgtattca    12300

ggatttttgc aaaatgagta gattttagct gctcttccat gggggggata atgcttaact    12360

atgtgagatg atggatatgt taatttgttt tactatagta accattttat tatataagta    12420

tctcataaca tcatgttgta caccttaaat atacacaata aaatttattt aaaaataaac    12480

ataggctgtt actctgcaca gtgggagtta taataatgac aatcttgtat ggttcttgtg    12540

cttattaaat aaaataatac atttaaactc ctggcacaga gcaagtgctt aaacagagat    12600

tacttaatgt tattattcat ttgcatccct ttgagttgat gtttatcaca ataaaaatgt    12660

gataagcctt taaatttctt ttaacctccc agcaaggcta atctgtgtat tttgtgcttt    12720

ctctctttct ttcccttatg ttcttccctt tctctttaaa aaaaaaaaca aacagattat    12780

gaggactatg gggattattg gagaggagac tatgaagtaa atggggtaga tggctatgac    12840

tacagccgcg gccagttgat tgaagatgtg gaacatacct ttgaagaggt aagcaaggaa    12900

ctgtacacac aaacagttgt ggggcagtgt atgggaaaga gggacagtga ctaaaggcat    12960

tctggctcat tcttaacaca ttggtcagcc attcccaggc ctcataaagt tatggaatat    13020

tagagtttga aagattttag agaataatag gacagcccct acagatgatc agaattgcgc    13080

tgctttcctc cttctttcag tcactgacca ttaattacca atagaaagac tataagaatg    13140

aaatattata agaacaaatg gtcctttaga ttataagtag gaatgatctt cttgagctac    13200

ctggggctgg cactgtcttc ctgtgttagc agagctatgg actttgcttt cttcctcagg    13260

acaattgata ctattacttt gagtaagcta gtcttcatag ggaagagaga gttttgtgaa    13320

cagaaatgtc ccatggatgt ttttccttca ttttggcccc atgcctcccc tttacgtgaa    13380

ccttcaaact tctgatgtga gttaccttgt cacagccata gtttggcaga gctatcaaaa    13440

atggaagtaa gacaaacaac tccccaaaaa ggaaatggga agaagacttg aataagtaca    13500

tcatcaaaga aattacacaa atggcaaata ggcaaataaa aagttattag ggaaatgcaa    13560

attaaagcta tgatgaaaat ccactccaca cccaccagga tagctatgat taaaaagatg    13620

gacaatacca agtattgggg agaatgtgga gacactggag ccctcttaca gtgcaggaag    13680

aaatgtaaaa tggggcagtc actttggaaa acagtttggc gatttcttaa aaagttaaac    13740

acacacttac catgactctt aggtttctat atgaaataaa tgaaaacatg tgtccttatc    13800

catagaaaga catacacaaa tgttcatagc agcaatattc ataatagccc caaactggaa    13860

aacccagctg tccttcaact agtgaatgaa taaacagact ctgatatact caaagtagcc    13920

ggagatagga gtggaactga ctacaagaaa ccttttgtgg ttatagaaat attaaaaaac    13980

tagatagtgg tgatggtttc ccggtagttt taatttattg aaactcatgg aactacacac    14040

ttgaaaatgg gtggctttta tagtatgtaa attatacctc aatgtaaaaa caaaggaagt    14100

aggtaacaat cttaaaaatg aatatatatt ttttgcatct gcttttattt tgggacctgt    14160

gttctcccaa gtatgtttat tggtttatgc agtggagtta tcatcaagtt ctaggaagaa    14220

ggaatacttt taaattttcc agaaatttga gagaagaaga attataattt ggggaaattc    14280

tacttgttta aagaatctcc tatttctagt gttgtggaat ggaaattaga attggttact    14340

ctttgtctta aactttcttc ctgggctttt cagattaaac cattatatga acatcttcat    14400

gcctatgtga gggcaaagtt gatgaatgcc tatccttcct atatcagtcc aattggatgc    14460

ctccctgctc atttgcttgg taagaagccc catgaattct tcgtgtactt ggctctttgt    14520

tatttctaac aataaaattg cctttttgag tgagccttaa cataaaactt ttgaaaaatt    14580

ctgtaagtgg ttagtaacat tgtagaaatc gcattttgaa agcattttct tcaaccaaaa    14640

gtctatttta aacaattctc tattgtatta ctttttttgt acataaagag ttattatttt    14700

ggctgcaatt caaatgataa aggggttatt taagataact agagaaagaa ttacaggctc    14760

aaatgagagt ggaaatgggg aaaataattt ttagtattca agttgattgg ctaagctctt    14820

aaggtggaat ttgagatttt agtatcatat tgtcagagct tggttggctg ggggtggtca    14880

ggggtaacag aaggttatag cttgagcgaa agcttcctaa gttcattcta gacttcacca    14940

attactcttg ctgaaaagtg cttggcttgg aatcgtataa gtgaagaatg aatgaaagtg    15000

accatcttcc cctctcccac cgcagcagct gaggccaaat aaaatataaa tatttgaaaa    15060

tttcatgcca tgcatatata gcatttctac tgtagtcaaa ctaagttgct ggaagctaat    15120

ctcctccaca gccatacctc gtgtctgtca gcaggagaga atgcggagaa aggacctgtg    15180

gaggctttta actctaaagt aatatggaaa tccttcctac aatgtcaatg gcaagcagta    15240

tttagtaatt cagtttctgc ttaaacctgt ctggtgtgat gggataattt cttcattcca    15300

atatagacta atttactgct acatggaacc aatgtaatac aattctacct tatgtggaac    15360

ttaagcaaca cccctctgat gccttccatt cattagccct atttccatgc tatgaggtta    15420

cccagaatgt caattcctat tctacaagat gaccttccag atattcataa agaaccatca    15480

tataagatat agcatagtac ctggtgcaat acattttagt gactattatt gttattgtca    15540

tgtttaccct attttctttt gtcaagttaa atatcttata cattatcaac cattccttaa    15600

aacctcactt ttctataatt gttctccttt caatgagctg tactttgtca atgtccctcc    15660

tcaattatca tgcttagaga tgaacagtta ctccagatga ggtttgacca acataaagaa    15720

agacatggta ccatgactac ctttgttcta gacactatac ttctattgat ttagctcaag    15780

ttcacattta tgctttagaa gccaggtcat actgtttgtt ggctcatttt tggtctttta    15840

catgtggact gtgctttagc ctgatgtcac atatatgttt ttatgatgga taggtttttc    15900

tttaaaattt aagcatagga cttcacatgt atcactacta aattttatgt tttaaaatat    15960

aagtttaggg agtactttta tttttttcag agtctcgctc tgtcgcctag gctggagtgc    16020

agtggctgat ctcagctcac cgcaacctct gcctcctggg ttcaagcgat tctcctgctt    16080

cagcctcctg agtagctggg attacaggct caagccgcca tgcccagcta atttttgtat    16140

ttttagtaga gacagggctt caccatgttg gccaggctgg tctcgaactc ctgatctcaa    16200

gtgatctgcc tgcttcagct ctgcaaagtg ctgggattac aggagtactc ttcatgaagt    16260

ttgttgcccc atttttttgg caccaggatt ctggtcctgc tcttggattg actttttcta    16320

gatacatctt cttttttatg gtccctggcc ttggaataca acttaacatt tgtttgagat    16380

gtttacaaag tcaccaagtt aagtacacga atataggaat aaaagtggaa tttagttacc    16440

agttagtaga agttcctgaa tgatgatctt atatgatctc ttttgaagcc aacactagga    16500

attactaaca gcttaatttg taatattttg taccatggat ggtagattat agaaatctct    16560

ttctaattta cagtgtcaat gatggtccat atatttaata aattatgtct acatttctgc    16620

tgtgttgtca tatactaaca gattcttttt taaatatagg tgatatgtgg ggtagatttt    16680

ggacaaatct gtactctttg acagttccct ttggacagaa accaaacata gatgttactg    16740

atgcaatggt ggaccaggta ggaaaaagag cccttaaaaa ctaaatctaa attctcaact    16800

tcatttattt ttatgtcatc cttctatttt tatttttatg tgaaaccatg taaataaaaa    16860

atttaagcta attgaaattt atttcttatg tagctatagt ttcatggaaa agcagtttac    16920

aatggcctca gataacttga attgcaggtg tagtattgat ctcattgaaa ggtatttgaa    16980

atggagatta cctgagtttt ccattaagcg gtaagatgta gaattgtcaa ctggttggta    17040

tcactcattc caaagtttgt cattgctaag taaccagcca gtaatctcta tggatagtaa    17100

aaacaagaat attatgaggg gatttttgca tatttaaaaa attattagtg ttaaaaatat    17160

tacaagaatc tttaaaacaa ttttaagtaa catctttatt actactttgg tttaattatt    17220

taaatgtgct aggttcctca aaacacaagt aagtacatag cccatggacc caataaagca    17280

actacacaat cgagactaca aagcaaccag ctaacaacag catgacagga acgcttcacc    17340

taacagacag agagtggcaa attggagaga aaaacaaaac ctaaccttct actgtcttcg    17400

agattcatct cacgtgtaat gacacccatg ggctcaaagt aaagtgatgc agaaagatct    17460

atcatgcaaa tagaaaacaa aaaagagcag ggggctgcta ttcttgtatc agataaaaca    17520

gactttaaac caacaacagt aaaaaaggac aaagagggtc attacataat gataaagggt    17580

tcaatttaac aagaagactt aattatccta aatatatatg cacccaacat tggagtatcc    17640

agattcataa acatagcact tttagaccta ggaaaagact tagacatcca gaaaataata    17700

gtgggggact tcatcacccc actgacagtg ttatacagat cattgaggca gaaaactaac    17760

aaagaaattc tggaaattct ggacttaaac ttgacacttg accaattgaa cctaagagac    17820

atctatagaa tattccaccc aacagctatg gaatatacat tcttctcatc tgtatacgaa    17880

acatactcta agactggcaa catgctcagt cataaagcaa gtcttaataa attcaaaaaa    17940

ttaaaattat gccaaacata ttctcagacc acagtagaat aaaaatagaa atcaatacca    18000

ggaggaactc tcaaaaccat gaaataacct ggaaactgaa caacttattg ctgaatgact    18060

tttgagtaaa caatgaaatt aaggcagata tcaaaaaatt ctttgaaaca aatgaaaaca    18120

gagacacagc ataccaacaa catatctggg atgtggcaaa agcaatgtta agaggaatgt    18180

ttatagtgct aaatgcctac atcaagaacc tagaaagata tcaaattaat aatctaacac    18240

cacacttaaa ggaactagaa aaacaagaac aaactagttc caaagctaga aaaaaagaga    18300

taactaaaat cagggcagaa ttaatgaaat tgagacctaa aaaatcatac aaaggatcaa    18360

caaaatgaaa agtcagtttt ttaaaaggat aaacaagatg gaaagacctc tagctagatt    18420

aacagagaaa gagagaagat ccaaataagc acaatcagaa atgacaaagg tgacattgca    18480

actgatccca cagaagtaca aaccttccta ttgagtacta tgttcatatc tggttgatag    18540

gaccaataga aacccaacgt cagtatcaca caatataccc ttgtaacaaa cctgcacatg    18600

tactccctga atttaaaatt aaaattaaaa ttaaagttaa aaaattatca ggccgggcac    18660

ggtggctcac agctgtaatc ccagcacttt gggaggccga ggtgggtgga tcacgaggtc    18720

aggagatcga gaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa    18780

aaaaaaaaaa aattagctgg gcatagtggt gtgcgcctgt agtcccagct atttaggagg    18840

ctgaggcagg agaatcactt gaactcggga ggcagaggtt gcagtgagcc gagatcatgc    18900

cactgcactc cagcctgggt gacaaagtga gactctgtct caaaaaaaaa aattctctgt    18960

gttcccttct gttgatgaaa tggtattata gttataatta tgtatatttg ttcattcaac    19020

taaaattcta cgtttctgag tagaatatct aatcatattt ctatttgcct tataaaattt    19080

attcagataa ttgcaccata atttactatt tgtgcattgc tgaacctttg cttgttaata    19140

gttttacatc tgtaagaagc aatgcaatga acatcttcac atacataaca tactcctggg    19200

aaaagtccac tgcagaataa aaagtgaaac tgcaagggcc tctaaactct tgtagctgtt    19260

gtagctccac tttgaagttg agcagcagta tagggccatc ttgatgtaga tttttagtct    19320

ttctaaaggg tttttacacc cgtctcttct attgtcatct ctgactcagg ataggtattg    19380

tgacagctcc atgctatagg tgaggaaact gaggctcagg taaatgattt gcccaaagtc    19440

acaaatcaca cagcctcatt ctttctgttt tttttgtacc aattaaccat cctcacctgc    19500

ccctgccacc ttcccactac tctttccagc ctctggtaac catccttcca ctctgtatgt    19560

ccatgagttc aactcttttg atttttagat gccataaata agtgagaaca tgtaatgttt    19620

gtctttctgt gcctggctta tttcacttaa tataatgacc ttcagttcca tctacgttgt    19680

tgcaaatggc aggatttcgt ttttttatgg ctgaatagta ttccaatttg tatgtgtacc    19740

acattttctt tatccattca tctactgatg gacacttagg ttgtttccaa atcttggtta    19800

ttgtgaatag tgctgcaaca aacatgggag tgcagatatc tcttcaaaat actgatttcc    19860

tttcttttgg gtatataccc agcagtggaa ttgttggatc atatggtagc tctattttta    19920

cttttttgag gaacctccaa actgttttcc atagtggttg tactaactta cattccttcc    19980

aacagtgtag gagggttccc ttttctccac accctcatca gcatttgtta ttgcctgtct    20040

tttggatata aaccaaaaaa tttttcataa atataatttg ggtggctgca cattattcta    20100

tttttcaaag gtatcattat ttatttaacc attctgatgg tcgtttcaac tttttctcta    20160

ttaaaaataa ttctcaatgt aattgttgaa tctaatttct gataattttt taggttagtt    20220

ccttagagac agcattactg agacaaagag aagaatttca aatgctatcc gtgtgtgtta    20280

tcaaattacc ttttggaaag gttatgccaa tgtatatatc caacagaaat aatgctgcta    20340

ttttaaaaat gacattagca cttttttcca ttttaaaatt ttattgtaaa ttgacattta    20400

ttattgtata tatttatggg gtacaaggtg atttcatgat ttatgaatac aatgaaaaat    20460

aattaaataa agctaattaa catatcaatt acttcacata ctttttttgc agtgagaaca    20520

tttgaaattt actctcttag caatttcaaa atgtacaatg ttctattatt aactatattt    20580

actatgctgt gcagtagatc tcaaaaaaat aaaaccaact tattcatcct gtttgagact    20640

ttgtacgctt tgaccatcat ctccccgttg cccccacccc atagcctctg taaccaccat    20700

tctactctct gcttctacca gttccattgt tttagattcc acacataagt gagaacatgt    20760

ggtatttgtt tttcggtgcc tggcttattt aatttaagaa tgctgttgtt ttgatgctgg    20820

aattaatact gttctctttt cccaggcctg ggatgcacag agaatattca aggaggccga    20880

gaagttcttt gtatctgttg gtcttcctaa tatgactcaa ggattctggg aaaattccat    20940

gctaacggac ccaggaaatg ttcagaaagc agtctgccat cccacagctt gggacctggg    21000

gaagggcgac ttcaggtagt ggggctgata cttacacaac tgatactaaa tgggagacaa    21060

cagaggcagg ctgaagttta acttgaattc tttctctgct tttctgagca cagaaaagat    21120

aagttaattc tccttgaact aaggctggga gtccaggaga gcacatttgg gttttcccag    21180

gaaaagagga ttgccagcag gctctaactt gaacctgtgg acaatctgct ttcttggaaa    21240

tatcatgcat ccattggcgt tgtatggtaa tggggatggt tgcacccata tcaggaaaga    21300

tttggtgcta agatttttgg aagatggaca tatgaatcac acattgatct tcccctccat    21360

gtttcactct tgtgaatgag acagaatagg tgaataaata cgcttggatc gaagggagaa    21420

agtggtacat gtcgtaagag agacacaggg catgctctat ggagaactgg aagaaaactg    21480

accacatttg caataggaga taggatcaga ccgtgcttta caagtgggat ttgaattagg    21540

tttggaaaga caagaaggat tcagatacac agagtcggga ggaggaccca agctgtgaga    21600

acagcaggat caaatacaga gaggcaggac ctgacctgca tactgaagtc ggcaagttag    21660

gctagaatga gaaataagtg aaggagagtt tgtgtaatgt ggcagaatga gcacaggctt    21720

cagaatccta ggtgtgtcac ttaatgacta tgcaaccttg gacaaggtat ttaactttct    21780

ttggtttcag tttccttatt ttataaagta gaatagtaat tcccaggttg caggcttgtg    21840

agagccttag gttggattcc ctagcttgaa aaggagatcg ttttacaagt gcttcattga    21900

ggagagctct gaggcagagg ggaatgaggg aagcaggctg ggacaaagga gggaggtaag    21960

taagaatgtg atctttactg gaaacttggc ctcagcctta tcccatgaag ctctctggag    22020

cataacttga gccacagact aggccacacc tcaagacaag ggggctagcc ttttatatca    22080

ggcagtcttt ggctgtggac tgccccagag tatgggggag cataaccccc atttagccaa    22140

aggcagtgaa gggagcagct gtaggccctt atcagctgtg actcaggcag ctaggggatg    22200

gtggataaag tcttggcagg cccgcaccag cattgactag ggtagggatt ggatctacag    22260

tccttttctg taaagggcca gatagtaaat agtttaagct ttgcagatct ctgttacaac    22320

tactcagctc tgcccttgtg acatgaaaac agccatagac aatacacaaa ccaatggatg    22380

tggctgtgtg ccaataaaaa tttatttata aaaacaatgg ctggccagca ggccatagtt    22440

tactgatgcc agtactagag tgaggcttaa aaatgagaaa gtataagtaa gttttcaagc    22500

acagaatctt acatacagta ggcagtaaat atatagtagt tatttttata attatttcaa    22560

aagagaatag agagaaacca aattagaaaa gtaggttggg gttgtgaaag gaaaatagat    22620

ttactgagca tgagatgaat acataactga atatttcctt accttccccc tttctcttgc    22680

aatgtgtgaa ttaccatgcc ctcccactat cctctccagc tcacttttct cctataaatg    22740

ttgaagccct caaaattatt tttggagaaa ggcacaaacc acagactgtt tctataaatt    22800

ctgtgttctt ttcttctggg catgttctta accttggcaa aataaacttg tgaattgatt    22860

gagacctatc tcaaatagtt tttggtttac agggtcatat tggtgtataa aaggtggctg    22920

agtttattct tgagcaatga ggaggcctcg caggatattg gagggggtgg tgacatgatc    22980

caagtggtat gaaatacatt taggaatcta ctgatgtatg acccctacac ccatctgaat    23040

gaaaatgctc ttgctaagtt aaaaaggacc accatctcat tgccaaatgc agttcttatc    23100

ccactgggct atagcagcat ttgacaagat ttacaagttg tctttcaaat gctttttttt    23160

tttaaccgac ttccacattg tcattctttt ccagatttcc ttgacctctc tgattgtact    23220

ttctccgtct cccctgaata atcttcctct ccccactcct taggtacttg gaccttctaa    23280

aggtttatct ttggtcctct tttcttgcat tctatacctg ttccatggcc catcatatct    23340

atttcccaac ttacatgcta atgattccca agtttcaatt tgcagcccct tctactattt    23400

ctctatcctg gcaataccaa acagcgtgca gtgtcctgaa tgccacattt ccacccccct    23460

gcccctaagc ctttctcatt gagcactaga acgtcaactt ccatgtcatc taccgggcaa    23520

actcctgcac attgattaag gtccaaattg ctcattgtat cctcagtcat gcccttcttg    23580

gtgcttctag ggaactgtgc ctacattcac tcatttttac gctcaaggct gtgtgtactg    23640

atcacttata gagtacttgc ctcagagttc ttgtagcgga gaactctgct tatctgtctt    23700

cctgttagtc tatgagcaag agaacaggat tcagctgtgc ccattgcttt atattgagca    23760

actagtattg tctctaggac ataagaggtg ggtactcaag attcactggt gaataaatct    23820

tggaaagatg attcatgcta ccaaaacccc atacaactcc actgtaatgg ttaaatgaaa    23880

gtcagtgaga ttcattttca tcttgtccat tttcatgcag gatccttatg tgcacaaagg    23940

tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag tatgatatgg    24000

catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc catgaagctg    24060

ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc attggtcttc    24120

tgtcacccga ttttcaagaa gacaatggta tggacatttt ctcatggctt gttttggagg    24180

ttctttaatc tgatatggga aaaggtattt attatcttat gtaggaaata tttacttttt    24240

gccacataag gtatgaggta tttatgggta actggaaatt actactggtg aaaaaattta    24300

agtatatatc agaacatgtc aacttttggt tttgtattat tgaaaaggga ataagagagg    24360

taactgaatg aatggacttg ggatcctgtg aaatatctaa cagaagtttt tttcttaaag    24420

atgatgaaac agtctcacag aactgaaatg gcttgtccaa ttagtgtcag cattctaact    24480

agacccctct ggttctaggt aaaaacttcc caaaacttta gagttggaat atattctaaa    24540

aaccatttta tagaggagta aactgaagac aagagaggga aagtagcccg aagtcaaaac    24600

gcaatgtagt ggcggaacca gaacaagagc cctaatctaa agtcttttcc ataatattat    24660

gcaaagcaaa gtgtagcttt aaattttgga attcttaaag aacaggtgtt taatatcaag    24720

attagaaggg attgaaacat tttgttcatc ctgctgaagc gtgaatttcc cctgtaacat    24780

ccccttagat ctgtgctatc cttcaacatt tctgcctgag gcagcccatt tccttttaga    24840

tgccttggac ttgatggaac atgacaaatg ttcaggagat ccaatttctt cagtgaggat    24900

gccatggctt ttgattcttc ctcataaatg gaggacaaat agagcctaat accttcttct    24960

cttctgtata ttctctcccc tatttttagt tatttgtgac ataaagatca gctcctctgt    25020

ctggagcatt tggtcgatga ggtcaaggtc atgagctcca tccttgagta gacaattcac    25080

tttgccttga tctctggttc cagatacttg gtgatcccac aagggcctgg gagtgagcca    25140

gtgtaaagcc tatcatcatg tttgaaatag ttactgtaag cacagtccta gtggattaca    25200

gaccagtagc agcatcctcc catgaagaca gtaacaaaca aaggtagtta acagtaacca    25260

tacctgcttc ctaattttaa aatatcatta attcaagtca atgaacagat attttattat    25320

ttttaaatat tccctgacag caggtaaaaa tggttgatga ctatgtttct taagatgata    25380

ttagatcagt gatgaaataa tctgtacaac aaaccccatg acacgagttt acctatataa    25440

taaacctgga cacatacccc taaacctaaa ataaaagctt tttttgtttt tttttataaa    25500

aaagatagta ttagacatgg ttaaaccacc ggtttggaaa actcctgctt tttttcttga    25560

ctctgcccct gatttgtgaa taatgttaaa taaattcctt tattccttcc attcctccct    25620

ccctctttct ctttctttct tcttccaaac atatttatcg agcacatact gtgtgcaaga    25680

catttttcta gacactggag acacagtgat gtgaaaagta gataacatcc cctgcttaca    25740

tttcaatgca tttccttcat acactagaga tgaactccac tgcctcttta tgtcactaat    25800

aaaggataaa atgaaataac atgatttgtt aaagcatttt aaattcttgg taaggaagat    25860

atccttacat ttaaagtaca ttgtactttt caccatccag tggatagtgc cctccaggag    25920

ggctcttttg tttcatttcc cctccctggt ttacaggctt ttcactgaat ctgtttagta    25980

tttgtttatt taacaaagac tcacagaagg catcacgtag cagacatggg actaagttat    26040

acagtcttaa atgagacatt aacagtcact gacttcatgg agctttccag aataaacagt    26100

gtgactggga aagtggatga aatagctcta atgaactctg ataagaggta tttaagggag    26160

gaaactgaaa ctaatgaaga aaatgaggat tagaagtaac tttgggtttt atttacctgt    26220

tctgttccag ggcttcaacc tactccaaat cccttagctg agaaaataaa tatatacata    26280

tcattatgaa tactgtcaat ttttctcatg tatccttata gtaagtacat cttgaggaat    26340

aatattttga ggttaggaaa attctcttta acacaaaaca tccactgtca tcttcatcgt    26400

aatatttatc cttttctatt ttactttcag aaacagaaat aaacttcctg ctcaaacaag    26460

cactcacgat tgttgggact ctgccattta cttacatgtt agagaagtgg aggtggatgg    26520

tctttaaagg ggaaattccc aaagaccagt ggatgaaaaa gtggtgggag atgaagtaag    26580

tcaatgaata tgcaatcagt aaaatgtttt ctaatgagtt tgctgtgtat ttaaaagcat    26640

ttgactggcg tgtacacaca cacacagagg cacacattaa ctaactactt tttgtatttt    26700

tagtttgtta tattttatat tttagtctcc atttggatac catctcctca gataaaattt    26760

ccttgggtca ggtgacacta cttcatactc tatattctta agtattggct tactcattaa    26820

actatgatat tatgttgaaa gtgatcaatt tattcatttt acatattctt ttatccagcc    26880

ttttaaacaa aacggtgacc ccacatttta ggcaaagcac tggggatcca atgttaataa    26940

tttcaggtat ggtcctcaac cccaaaaaac gtttagttta tggcaggatg tggaaaatta    27000

aaccactgca atttgtagtg ttgtgatggg agggtacagg gtccgttagc gtccagggga    27060

gatccaaagc ccaactgggg gtgtcagatg aggagaggca tttaagccct gagaaaggtg    27120

tgggtgtaga ggggaacaca gagaattcca agctagagag aacctgacac atttgggcaa    27180

cagtgaccat ttccatggtt gcagcactac gttacttatt gctgtgtcac aagtgcctca    27240

cactgtgcct gtcacatgca agtatgaaat aaataggttt ttggaggaag gaattataag    27300

agaaaaagaa aaagaaggaa aaaaagaaag gagagaggga gggagagaat ggaaacaaga    27360

aagaaatcta tcttcttttt accatcatag accctggtca attatttctt tctttatttt    27420

tcttatattt tctttttgaa gtgaagaact catgtgtaac aagcagttcc acatgcacag    27480

gtttaaaaca gtacacttct tctgtcaaga ttctctctgt taacataaat cgtacttggg    27540

aggaaagacg cagcacctat aagaactgtt gccagtgttt aaatattact gaagttatgt    27600

ctacaatgat cctgcaattt taaaggaaaa atgtattcca tttaatcaaa gccaaataca    27660

tgattttgct accttttttt ctggttggat taatcttttg acccctctta gcttatttta    27720

aaggcacatg gaatcagatc cttagagtga ttcattaatg catcaattgt tcctttgttc    27780

agtaaatata aattaattct ttctgtagtg tcaggcacca tgtttgacac tggaattaga    27840

gagaagacca agacacagcc ccaccctcta ggagctcaag tctctagggc aggaagttac    27900

tatagttgaa taactacaaa acggggagat aaatggcaaa ggaggcacaa ctagagaagg    27960

ctaaaggaga ttgaggggtt aattctgcca gaaggtggat gggatcaggg ccaggcttca    28020

cagaggaggg aacacttgag ctaggtaggc gtggagaata agtaagattt caattttatt    28080

aaattctctc tgccaggagt acatgaagtg tggtgcctga gaggaattat tagggctttc    28140

actgtacatt tttggccatg caatgcactt tatgaatgtt attaaattag tcttttgaag    28200

acatagctat tttccaaggg tatattctgg ctgaattaat taaaactaag agataactac    28260

ataatgagct ttactgtctg attttttaaa aatttttatt tattttttat ttttgtaggt    28320

gatttttttt tacattgttt ctatttcacc caacaaccat ttctaatgta aataccattg    28380

attggctgga cacggtggca cctgtaattc cagcattttg ggaggccgag gtgggcagat    28440

cacttgaggc caggagttcg agaccagcct ggccaacatg gtgaaaccct gtctctatta    28500

aaaatacaca aattagttag atgtggtggt gcacacctat aaaccaagct acttgggagg    28560

ctgagatggg agaatcgctt gaacctggga ggcggaggtt gcagtgagcc aagatcgtgc    28620

cactgcacta cagcctgggt gacggagtga gaccctgtct caaaaaaaaa aaaaaaaaat    28680

ttgattgatg aaactgcact agttatgccc acctgcttgt gatgcttgtg atgggtgatc    28740

cacagctaat gtattgtttt cttttctccc caaaggcgag agatagttgg ggtggtggaa    28800

cctgtgcccc atgatgaaac atactgtgac cccgcatctc tgttccatgt ttctaatgat    28860

tactcattca ttcggtaaat tacagttttc ttgtttctgt ttaacttcta gggtttgtgg    28920

acagctgtgc taataacgac aaaaagtagg gataaatgaa gtgataatta taatttttct    28980

atttccaccc ataactacca agctcaatac agatgctcct tgctttacaa tggggttaca    29040

tcccaataaa ctcatcataa gttgaaaata ccttaagaat gcgctgaata cacctaacct    29100

atggtacacc aaagcatagc ctagtctacc ctaaacatgc tcagaacact cacattagcc    29160

tactgttggg caaaatcatc taacacaaac cttattttat aataaagtgt tcaatatctc    29220

atgtaattat ttaatactgt gctgaaagtg aaaaactttg ggtacttacc attaacatat    29280

acagctgaaa gcgctattgt aaagtcgaaa aatcaaaagt ccaaccgttg taagttggga    29340

actgtctgta tagatgatca atttcaattc aatttaaact aacacaattt attgggttaa    29400

attaaacttg tgtaagatct tgtccccgtc atcagcaatc aatagtatca ttgggagaaa    29460

taaaaagtag ttttgtcttc ttgttactgg cagtttattg tacattgtga tagagaattt    29520

ttaacttgaa gtccaaaaac atatgttctt cacctactaa ccccagtcct tgaatttgct    29580

ggagctcagt ttatttgtaa aatgaaaata atattatcga cctgttataa ggatggattt    29640

gcatcattta tgtgaaaggg ctattaatct gtaaaacaca aaacaaatgt tagctaacat    29700

ttaacagagt aatattgcca tgtttatcaa cagatacata aaacacaaat aggttatgat    29760

gagtgtagag ttcatgtctg gagaaagaga tttcagagat ttgatcagta tctctttggt    29820

tacttgggct ccagatttaa atatatgccc taatctataa ctctaagaca gtaagtaaac    29880

acgggactgc ttttttgttg ctttgtctcc tgtgcagata ttacacaagg accctttacc    29940

aattccagtt tcaagaagca ctttgtcaag cagctaaaca tgaaggccct ctgcacaaat    30000

gtgacatctc aaactctaca gaagctggac agaaactgtt gtaagaaata cctcaaaatg    30060

ttgaacctct cctagtattc agtattactc atttccatgc ctaggtttgt atttgatttc    30120

tttgttctaa aaagaaaatt ttatggcctc aaaatgtcct catttacaaa ccaaacattt    30180

aatttgtggt cagacaggaa cctagaccat acaacaattg ggtgggccac ctcttttctc    30240

cctatcataa ctacagccct ctcttcctgg taattggaag gaaagagcgg tttagggtgg    30300

aatatatctg ttaatatgca ttcttttctt atctgccaga agcaaattta gccaagtcaa    30360

agagaagaaa ccatagatca tagatgtaaa tatatgtaca tctggaaccc ctcaaaaggc    30420

cctgaacccc ctttttttgt gtagcaatat gctgaggctt ggaaaatcag aaccctggac    30480

cctagcattg gaaaatgttg taggagcaaa gaacatgaat gtaaggccac tgctcaacta    30540

ctttgagccc ttatttacct ggctgaaaga ccagaacaag aattcttttg tgggatggag    30600

taccgactgg agtccatgtg agtacaccca gttgacaagt ttcacaccca ttccttgtct    30660

acttcgtcta gtctcctttg gccccagtct catgaggact tgtgacacag ctgagaatgt    30720

ttctttctct atagtacctg cttctttctc tgctatggtg acagctgcca ttttatggga    30780

gaaaaatcac aactgttgag cacctatgta tgagacatag tgaaagcaac tgtacagaca    30840

aacacacaca gatgcatgca catgtgtgca tacacataca agagtgtgta ctctttcaag    30900

tctgttttat tagtctcatc tttaaaatac atattataac tgtctccaac caactgtact    30960

cgaatcctgc tttccaaaga caaatacttt ttttaaaaca attttaatgc tattatctct    31020

tctttctggc agtcactttc atatttctaa ataattttct tatattgcta ttttgttatt    31080

gctcagtttt aaaccttcgt tttggtctac tcttccactt ccatttcttg ctcttccaat    31140

aaggccttat aatgattttt agtaaaacag ttatcaatgt ttacatcact atgcctgaag    31200

agccaagtaa tgtattattt tgtgtccttt cttatgtggc ttgttgtttg tctcaaagtt    31260

tctacttgcc tgaatttttc ggcttaccta atttgctatc tacgttgtat ttgtttttct    31320

cccaaatatt tcaacatatc tattcttttc agtctcattt tttttcccta gagacttccc    31380

tcttggagtc ttatattctc ctttcccaac atttgttgtt ctcctgggtt gaatccactg    31440

cttcctagat tccatgtctt ctttcttgga ttacctcttg tttttctgga gcatagcctc    31500

ccacagactg tccaagcagg ggcacaaggg gtaggaggat caactgttct ccaaagtggt    31560

tttaaccaca ccctgacttc cattcctctt cttttcagcc cagtattatt ttcccaccct    31620

cacctgtgct tgaattccaa acctcttttg gattttttgg ctctttgtgg gtctgtgcct    31680

cctctgtgta caaattaggt catggcttcc tgtccctgag aaagcagtta cccctgtctc    31740

atcatttctc gttttccaaa agcctgttga tacctttaaa agatcccttt actatcactt    31800

tagtgggatc tttggaggaa aaggaaataa gcacatgtgg gcaatctgtt gtctgtaacc    31860

agcagtctgc tatttctctt taatcagatg cagaccaaag catcaaagtg aggataagcc    31920

taaaatcagc tcttggagat aaagcagtga gtattctgga cagtgaattg attatttttg    31980

agtgcacagt cttcacttaa ataggacaca ataaacccat ttcagtgtga actgaaagaa    32040

gagaggccat gtggttcttt tcaaaactat aagttccaga ttctggcctt tgcctttggg    32100

tttttaaagt aacctattcc ttattggata agctattcct acttcttatt gccttgaagg    32160

tgttatgaac ttcaatgaga aaatatctgt atcaatcctt aaatatcaga taccaatcct    32220

ttcaattgac tctcgtcacc attactttta ttctagaaag agaatatggt tatattttga    32280

aaggtagttt gtttttagaa gcggtacagt taggtttttt tagtttgttt tgttttagtc    32340

aatcacctgt atcctggctt cactcagagt gtggcccatg gtccagcagc atttgaatca    32400

cctggaagct tgttaaaaat gcgtaatttc aagcctagcc ctggaccact taatcagaat    32460

ctgcatttta gcaagcctcc aggtgatttg tacgtacaat caagactggg aagctctaat    32520

ttagaacact gcttctcaaa cttggctgca cagtggaatc acatgggaag tttaaaaaat    32580

attaatgcct aggttataca cctccagaga ttctgattta attgttctgg ggtatggagt    32640

caagagttgg gcatcaagag tgtttaaagc tccccaggtg attctagtca cagcaaagtt    32700

tgagaaccac ttatttaggg aaatgcattt tgggggtaac aaaatatttt acaggaaatt    32760

atgttattta caccttaatg tgaattattt acttagctat tgctctgtcg ttaacacctg    32820

tctcagatga tccagtctga ggaagtggta gctttgattg ggaaagagga gaggaaagag    32880

tagtctcggg tagatggggc tcaaaagcct gagagtgggt atgacaccct gaaggctttg    32940

cagggttaga agtcaatctg ggactattgg ataaaatggt ccaagatgct acagcaaatt    33000

gttgtctgca ttggatagat ccaaagattg tgtttctacc cccttacctt tcctgaaaag    33060

ttaaacattg tccaagattc aataacactt ttagtataat tttcatagtt aagacatcaa    33120

aacataaata actcaggagt aaaaagatga acattcaaga aagaaaaaat gaaaatggaa    33180

gtgcatttct ttccaatcat taagagttca agttcctatt tcataataat cattgggtga    33240

ttgtgggact atttctctgt catattttta ttagctcttc cttggcttaa tacattttaa    33300

ttagtctcgg cagatcagga tattttcaat tatctttttt cttgacattt atactcatcc    33360

tctttccatg cagtgagggt tggtaaatag tgttcaggga gtttgattct gtaatgttct    33420

gaggccaatt cactgagcaa caatctgttt tgatgaaacg agatcatata tttagtgcat    33480

ctacacaaca gggtcagaat atctgctcag ttcaaactat ttcatggtga attccaatgg    33540

atctatggca ttattttgag aactcagcct ttaaaatctt ttatatttta tatttataga    33600

gatagtagcc agactgttat tagtaacaat attaataata ttattactat taaaggaact    33660

cctctaaacc tcggtgaaac caagctgaag tgaatgtaac aattcttttg tgaaatatta    33720

taatttttta aagggaaagg agaaacatac aactagtgcc attcattgat tcctactgcc    33780

agctactgga ggaaagagtg aatgctttct tttaagtctt taaaagctat gcaaacataa    33840

gctatttgtt tagcactgga aaacaagaac aaacagatta gcttgctgtt tacaaagtgt    33900

tatttttcat ttgaacgtca agtttttctt ttacacttat agataagtac atttctgaga    33960

acgtaccata aaaatagtaa aaactgattt tgtccacaag gtacagacat tttgctacaa    34020

aacccacaac ttttgtttga ctcccatcgg taaacctaca ctcaaggtgt taatttcagt    34080

ttacatcaaa ctaaagtaaa aggacccgtg aacccaatgg ttcctaaagc atggttgcct    34140

gaccagcagc attaccacca cctgggagtt tgttagagat gtaaattatt gggtttcatc    34200

tcgggcttcc tgaatcagac gctctagggg tggacccagc actcagtgtt gtaactaacc    34260

cttcaggtga tacggatgca cacttacatt gaaggtcact gacttaatga atagcaagaa    34320

tctctggaat attaagaata attcttgagg agtatcagat tataaatgtg tcttacgagt    34380

ccctctgagc agtgtctttc ttctgaattt gcagtatgaa tggaacgaca atgaaatgta    34440

cctgttccga tcatctgttg catatgctat gaggcagtac tttttaaaag taaaaaatca    34500

gatgattctt tttgggtgag ttgatttgct gggttctcaa attactccaa ctaggatttc    34560

tcttactctt gagtctgagg agatactctg cctaaacttt tcttcaagtg aaattgataa    34620

aaatctccta gtaacttata cttctttggt attgtggaat ttgggtgact ccatagaggg    34680

ctgatcgtgc cttatttgac tggtaaattg caagagtatt gttcttacta aacagctgtc    34740

actctcttct cagaatgctc tcatacaccc tcagcactga aagaaaaaaa aggcagaact    34800

tcctgccttc attgacctat attctagtat gtatgttgtg tatgtgtcta tgtgtgtaat    34860

atgtaagtga aatatagagt tacaaggtac taagtgctag gagaaaaata taaaagggtc    34920

tggggagggc tggtgtgtgt gtgtgtgtgt tgggcagggg gtaggtcaat tttaaccaaa    34980

atggtcagaa aagacgtcac taatacttga acaagtatat gaagcaggag agagrgagmg    35040

agagagcgag agagcgagag agcgagagcg agagccagca atgcagacaa tggggaaagt    35100

gtctcagctg ggggaaacag caggtgcaga ccctgaggaa ggaatatcct cagcctgtta    35160

aaggaacagc aaggaggcca gtgtggctgg agcagattag aagacaagtg gagacatggc    35220

caggacgatg ttagggcata gaggaaggag ggagagacaa aaggtcatgt gggccttgaa    35280

ggccattcta aggactttgg cttttattct gagttagatg agtagtcact caagggctat    35340

gagccacatg atctacctta ttttgtgcta ggatcgcttg acagctgtga gagcacagtc    35400

ctgtcacatc atatggtaga ccccactcat taccttcatc catgggtgca acacgacgtt    35460

ttctgctggg taggaccagg ttgtgggtgt aaatccgtgt gtggtactca gccatttctg    35520

cccaccacat tgtttgccac aatcctgggc caccgattat tccttgttga ttctcctgct    35580

gttttcagtt tggaaatttt ctataattga aaaagatgtg ggttttatat aaaggcagaa    35640

caaatagtgc caaaacttga tatcacaatt tttatgtagt tgatttcatg tgctttgggc    35700

agcattaatg ttttttttga caattacatc ctctcattgt ttgccctccc ccatgtctct    35760

ctatcctgtg attctctctc taatctcctt ttcaccagca ggggaagtct tcattctctt    35820

gattgtgtcc tctgtgccac aagtgaagat gtttgttttg tttctctaca gggaggagga    35880

tgtgcgagtg gctaatttga aaccaagaat ctcctttaat ttctttgtca ctgcacctaa    35940

aaatgtgtct gatatcattc ctagaactga agttgaaaag gccatcaggt gacattttac    36000

tttcatctaa gggtgagggg gttaccaaat acaacaacaa taaccagtat tttgtgtgtt    36060

cttcctgtgt gccaagcatt attctgagtc atttacatgt gttacctcat gctacaaact    36120

ccacgtaatt ccagaaggat cccacagcag gggaataatc ttgatttgag ttccgccaga    36180

tgtaggctct tacaaaaggg aagaaaaact atagattaca tgttatcaag caagttacca    36240

ctatgggcaa ctagagctca gtcctgctgg gaaatgtgga gagactgtgt agaatgtgca    36300

cctgaattgt cccatcagag ggctgaggaa gctggggtat ttatttacca cctcccatca    36360

gttattggct gagaactgct tccaggtggc attaattccc cagcatttca gccctgcagg    36420

cagggcagat cttgtggtct gagaatgctc tctggtaaag gggagcaggt gctggttgaa    36480

gaaagtctgg ctagaactca tggaaaatag taagtgcaga agggacgtgg acaggtattg    36540

ccatcatttg ctctcaggac tttgatgtag gattcattta actgcccaaa tcctgaaaca    36600

aggtaggcaa gtacaggatt ccttacatat tgcttggcct ctatgctagg tgagggactt    36660

gcaatgaatg tttagaagaa acagtttgtc caatttgcct caattgtttc ccacaacaga    36720

cagcaggagc gaagaatgga ttgaccttgc agatggtttc ctgtcattat aaaaaggctt    36780

aatataccta ctgcttctgg gcagctcact aggtggccct ctcgagctgc gtcagagtcc    36840

tgtttaactt cggaagcaga tctaagacct gctgggcagg gtgtgcctag aaaatctggc    36900

ttggttggag tgtatgaccc aactgtgccc agagactcac tcacttcctc cagaagactt    36960

gtgtctgtct tgggaaaaac ttctggctga gatctttatg aaaaagctca gccttcctgg    37020

atactcagct gcaagctaca ggggacctca gactctctgt ttccaggatg actcttttca    37080

gatcttttct ggctgaggtt gccaggggtt acctgactaa ttctgcgttg atctctctct    37140

ctctctctgg tggactctga cctcctgacc tgggctatac ccaagggtag gaagatgaga    37200

tgccagacac tttggtcttt gatccagaat gttctccata tcattgtttt tttttttctt    37260

taaacaatct ttatcctttt gcctccataa aagtaagcca tttcccatcc cagtgctgaa    37320

gaaactggca aaggtccctt tcttatgtgc ctccccagtg ctacctccaa atgccaatac    37380

cttttatttg gaaaatatta ctatagagac ttggtcatag gacctgattc atttgtataa    37440

tagaagaggt gtatccaatt atccgtttcc attatttgat ataaagtcat tgtagatgta    37500

ctctgacaga agggaaattc ttgccaaata tgataacttt gcccttaaac acagcagtca    37560

caaatgaata aatgccaacc atttatacat ttccacactt acaactcaat tttccaatgg    37620

agctgttgat gaacctaatc tcgagataac ttcgtataat gtatgctata cgaagttatg    37680

ctaggtaact ataacggtcc taaggtagcg agctagccta ggttgcaagg catgaaagat    37740

gcataattgt caaagactta tatctttaat tagacctatt tactttgctc ttatgatttt    37800

aggtgtatat tccttttttt tttttttgaa acagagtctt gctctgtcac ctaggctaga    37860

gggcagtggc acaatctcgg ctcactgcaa cctctgcctc ccgggttcaa gcgattctcc    37920

tgcctcagcc tcccaagtag ctgggactac agacatgcgc caccatgcct ggctaggtgt    37980

atattcttat gataagctct attatatcct ttcaggaaca atgatataaa cagtaaataa    38040

ctacacacaa ttttattttg tctaagtgtc ccctttgctg ttttttgctt ttgcaaatag    38100

gatgtcccgg agccgtatca atgatgcttt ccgtctgaat gacaacagcc tagagtttct    38160

ggggatacag ccaacacttg gacctcctaa ccagccccct gtttccatat ggctgattat    38220

ttttggtgtt gtgatggcac tggtagtggt tggcatcatc atcctgattg tcactgggat    38280

caaaggtcga aagaagtgag tatcctttcc tagatttatc tgtcttttta gaatgcatga    38340

attggaaatt ttgcaacaaa taacactgta tccacacagg ataattactt acttggacat    38400

ttatctccct aaatattctg atatatccca tagaatcttg tcagatgcta gcagtacctt    38460

accttactag caagctcaca tattatagat gtctagcctg aggtttattg ggatgctgta    38520

gtcaagtgca tcctatccac agtggcatag ccagactgca aactcagtaa ggcattgttc    38580

tcactcatga ctcttgcttc atccacagag actgacatgg agcacaaagt gtaatgtcat    38640

ctaagaatga ggtgcttcaa actactactc tttagttact ttcattcctc cttgggaaac    38700

tcaaatttat catttgagtt catgggcagg caccctttaa tttgttctag agctgagttg    38760

attgagggct ttaatcacca gggactgact tctagctcct gtcttgagaa agtattaact    38820

cttgttggtc tgttcaaata acttagtatt ttgtatcact ctgacaacat tatctgcatg    38880

ttttcagttg tttaaacata ctctcagttg aatctttaca caaattagtt tattttattt    38940

aattttcttt actatagaga tctctcgatt ctaccaaata acttcatttg aaaaagcaag    39000

gctgtggaga tgggtaaaat cacctgcccc acaagcatga ggacctgact ttgaatcccc    39060

agagcccata tataaagcag atacaggagg caagcatcta taatcccagc actcctccag    39120

ggagatggaa ggcagaggca ggaaagtccc cagaagtctg taggccactc agcctggtgt    39180

acacagcaga ggcaacagac cccatctcaa tcacaatggg tgttgagaat caacactgga    39240

tattgctgtc tgatccccac gtgtgcaatg tagcatacac acttacacac atgcacatgt    39300

gtacgcatac acagatgtgc acaaagcact ttctaggtag tgcagtcaac atggttacaa    39360

tgttcaaaaa tacaaggggg tcatagagtt ccgttaccat tctttgtttc tgagtttcct    39420

tttaaccaaa gttatcagtt tttagtaaaa tgaactatgc actacatatt cttatttacc    39480

aactagtatg ttttagaggt atttccagat ttttcaaaaa attcccaagc aatatatttt    39540

agagattctt tcagattggc tatgtaaagc acttccattt gcctggtaat gtagttgccc    39600

actttgtagc aaatgggtac tcccatggtt accaaatgtt tgtgtctatt taaaaaatac    39660

aacaatttca aataggcaat ttcctgtgca tgctaaagta ggtgcaagat atgtcccagc    39720

aggtaaaagg ctaggttaaa atcatcatga attctaattt taattaatac ttctgaactg    39780

ttctcatagg ggcagaatta atgtacaaac agcaccagct tatgaaagct ctccttttct    39840

ccaactcagc atccttagca cagggtgcca tcagactttt tgacagttat cctttgggtc    39900

agtgtaagta agtgtctttc taccatcact ttaataagga gactttgttt tatttgacag    39960

gaaaaatgaa acaaaaagag aagagaaccc ttatgactcg atggacattg gaaaaggaga    40020

aagcaatgca ggattccaaa acagtgatga tgctcagact tccttttagc aaagcacttg    40080

tcatcttcct gtatgtaaat gctaacttca tagtacacaa aatatgagag tatacacatg    40140

tcattagcta tcaaaactat gatctgttca gtaaacgttg tccaaagagc atcagacttg    40200

agtggacatc ttcactgaca ttgctttcag tatttatttc tgcctaagga tttgacatct    40260

cttctgttta ttaatagaga tgtttatctt agcataaaag agggaaatgt gcctttggcc    40320

tcacagtcta tccagggtga tatggttggg taactggagt tagaagatga gatgatgtct    40380

cttgggggca agtgttggct tcggtgtggc atctgggctg tgaactggtg ggactgttga    40440

ggttgagaat ggtgctcgct ggtcacttga atccaagtgt gacgtcatgc tctgtggctt    40500

ctgccttcac acttctcact tcaagtactg taggaatttg ttcacagtaa tacttgaaat    40560

ggactgtccc ttctttggag gtgcagttca acggagaaag aagccagaca tcaggtagag    40620

accatgacct tttctcttcc aaacttgatc aacatctctc taacaagaca cagctagcac    40680

aggaaactcc acgaacccag agcatgcctg tcagaaacta cttccattat tctcccattg    40740

tggagtaagg gaaaattcca gatgaatgct cgatctgtga gatgggtgcc cagtctctga    40800

aattgtttgt attttctcac agggtctgag caatggtgaa cacaaagccg acctcaataa    40860

atacttatta gatttagaca ctcctct                                        40887


<210>  23
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human //XhoI/ (loxP)/ICEUI//NheI// Human

<400>  23
catttataca tttccacact tacaactcaa ttttccaatg gagctgttga tgaacctaat       60

ctcgaataac ttcgtataat gtatgctata cgaagttatg ctaggtaact ataacggtcc      120

taaggtagcg agctagccta ggttgcaagg catgaaagat gcataattgt caaagactta      180

tatctttaat tagacctat                                                   199


<210>  24
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24. Humanized human/mouse ACE2 protein


<220>
<221>  SIGNAL
<222>  (1)..(17)
<223>  Signal sequence of chimeric human/mouse ACE2 protein

<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Mouse portion of chimeric human/mouse ACE2 protein

<220>
<221>  MISC_FEATURE
<222>  (18)..(740)
<223>  Extracellular Domain of chimeric human/mouse ACE2 protein

<220>
<221>  MISC_FEATURE
<222>  (20)..(740)
<223>  Human portion of chimeric human/mouse ACE2 protein

<220>
<221>  MISC_FEATURE
<222>  (741)..(805)
<223>  Mouse portion of chimeric human/mouse ACE2 protein

<220>
<221>  MISC_FEATURE
<222>  (741)..(761)
<223>  Transmembrane domain of chimeric human/mouse ACE2 protein

<220>
<221>  MISC_FEATURE
<222>  (762)..(805)
<223>  Cytoplasmic Domain of chimeric human/mouse ACE2 protein

<400>  24

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Thr 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Ile Phe Gly Val Val Met Ala Leu 
            740                 745                 750         


Val Val Val Gly Ile Ile Ile Leu Ile Val Thr Gly Ile Lys Gly Arg 
        755                 760                 765             


Lys Lys Lys Asn Glu Thr Lys Arg Glu Glu Asn Pro Tyr Asp Ser Met 
    770                 775                 780                 


Asp Ile Gly Lys Gly Glu Ser Asn Ala Gly Phe Gln Asn Ser Asp Asp 
785                 790                 795                 800 


Ala Gln Thr Ser Phe 
                805 


<210>  25
<211>  2418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized human/mouse ACE2 CDS


<220>
<221>  sig_peptide
<222>  (1)..(51)

<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  Mouse portion of CDS encoding chimeric human/mouse ACE2 protein

<220>
<221>  misc_feature
<222>  (52)..(2220)
<223>  Extracellular domain encoding portion of CDS encoding chimeric 
       human/mouse ACE2 protein

<220>
<221>  misc_feature
<222>  (58)..(2220)
<223>  Human portion of CDS encoding chimeric human/mouse ACE2 protein

<220>
<221>  misc_feature
<222>  (2221)..(2418)
<223>  Mouse portion of CDS encoding chimeric human/mouse ACE2 protein

<220>
<221>  misc_feature
<222>  (2221)..(2283)
<223>  Transmembrane domain encoding portion of CDS encoding chimeric 
       human/mouse ACE2 protein

<220>
<221>  misc_feature
<222>  (2284)..(2418)
<223>  Cytoplasmic domain encoding portion of CDS encoding chimeric 
       human/mouse ACE2 protein

<400>  25
atgtccagct cctcctggct ccttctcagc cttgttgctg ttactactgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttatttttgg tgttgtgatg gcactggtag tggttggcat catcatcctg     2280

attgtcactg ggatcaaagg tcgaaagaag aaaaatgaaa caaaaagaga agagaaccct     2340

tatgactcga tggacattgg aaaaggagaa agcaatgcag gattccaaaa cagtgatgat     2400

gctcagactt ccttttag                                                   2418


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence of chimeric human/mouse ACE2 protein

<400>  26

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Thr 
1               5                   10                  15      


Ala 
    


<210>  27
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of chimeric human/mouse ACE2 protein

<400>  27

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser 
            


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ransmembrane domain of chimeric human/mouse ACE2 protein

<400>  28

Ile Trp Leu Ile Ile Phe Gly Val Val Met Ala Leu Val Val Val Gly 
1               5                   10                  15      


Ile Ile Ile Leu Ile 
            20      


<210>  29
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic domain of chimeric human/mouse ACE2 protein

<400>  29

Val Thr Gly Ile Lys Gly Arg Lys Lys Lys Asn Glu Thr Lys Arg Glu 
1               5                   10                  15      


Glu Asn Pro Tyr Asp Ser Met Asp Ile Gly Lys Gly Glu Ser Asn Ala 
            20                  25                  30          


Gly Phe Gln Asn Ser Asp Asp Ala Gln Thr Ser Phe 
        35                  40                  


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mTM Fwd

<400>  30
ggcaaccttt cctgctaaga a                                                 21


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mTM Probe (BHQ)

<400>  31
cggagccaat gaagggttcc atga                                              24


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mTM Rev

<400>  32
gctgcagaaa gtgacatgat ttc                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretU Fwd

<400>  33
ccctcctcct ccagtgtatc ttt                                               23


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretU Probe (MGB)

<400>  34
cagcttttaa ggaacatatt                                                   20


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretU Rev

<400>  35
gctaacattt tatggccaaa tcaa                                              24


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretU2  Fwd Primer

<400>  36
tcgcgagaag caaggagatc                                                   20


<210>  37
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretU2 Probe (BHQ)

<400>  37
tctgtgcttg gaaaagcatc attgcc                                            26


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretU2 Rev

<400>  38
ggagagaaga gctggtgtag atg                                               23


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD  Fwd

<400>  39
cgttgtccaa agagcatcag ac                                                22


<210>  40
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD Probe ((BHQ)

<400>  40
tggacatctt cactgacatt gctttca                                           27


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD Rev

<400>  41
gaggccaaag gcacatttcc                                                   20


<210>  42
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD2

<400>  42
tctggctata aggaagcaag gatg                                              24


<210>  43
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD2 Probe (BHQ)

<400>  43
agagcaactg gagttcagag atccaagg                                          28


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD2 Rev

<400>  44
ccactgccta tggaacaatt aca                                               23


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD3 Fwd

<400>  45
gggatttgcc acttgatcct tt                                                22


<210>  46
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD3 Probe (BHQ)

<400>  46
cccttgagta gagaagaccc tggcg                                             25


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD3 Rev

<400>  47
cagccaccag gacatctaca c                                                 21


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD4 Fwd

<400>  48
actgacatga gagtgctgaa ggtt                                              24


<210>  49
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD4 Probe (MGB)

<400>  49
atgtggagga agaagat                                                      17


<210>  50
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034mretD4 Rev

<400>  50
acaaaagatg ctcaggtaga aatgaa                                            26


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mGU

<400>  51
ggatgggatc ttggcgcacg ggg                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mGU2

<400>  52
tcttggcatt ttcctcggtg agg                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mGD

<400>  53
aagtctcctt attaaagtga tgg                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mGD2

<400>  54
agagaaccct tatgactcga tgg                                               23


<210>  55
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90034 Border A

<400>  55
atctgtcctc tccaggatta acttcatatt ggtccagcag cttgtttact gttctcttct       60

gtttcttctt ctgctttttt tttcttctct tctcagtgcc caacccaagt tcaaaggctg      120

atgagagaga aaaactcatg aagagatttt actctaggga aagttgctca gtggatggga      180

tcttggaaaa ggagaaagca atgcaggatt ccaaaacagt gatgatgctc agacttcctt      240

ttagcaaagc acttgttatc ttcctgtatg taaatgctaa cttcatagta cacaaaatat      300

gagagtatac acatgtcatt agctatcaaa actatgatct gttcagtaaa cgttgtccaa      360

agagcatcag acttgagtgg acatcttcac tgacat                                396


<210>  56
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   hEx3-4 Fwd

<400>  56
aacccagata atccacaaga atgc                                              24


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   hEx3-4 Rev

<400>  57
gcccagagcc tctcattgta g                                                 21


<210>  58
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hEx3-4 Probe

<400>  58
ttgaaccagg tttgaatgaa ataatggca                                         29


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hEx16-17 Fwd

<400>  59
ttgaaaaggc catcaggatg t                                                 21


<210>  60
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hEx16-17 Rev

<400>  60
gtcattcaga cggaaagcat ca                                                22


<210>  61
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hEx16-17 Probe

<400>  61
ccggagccgt atca                                                         14


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEx11-12 Fwd

<400>  62
gagcctctgc ctcatgatga aac                                               23


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEx11-12 Rev

<400>  63
tgcttgacaa agagcttctt ga                                                22


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEx11-12 Probe

<400>  64
tgtgaccctg catctctgtt cca                                               23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEx17-18 Fwd

<400>  65
ggttggcatc atcatcctga ttg                                               23


<210>  66
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEx17-18 Rev

<400>  66
tcgagtcata agggttctct tctc                                              24


<210>  67
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mEx17-18 Probe

<400>  67
tcactgggat caaaggtcga aagaaga                                           27


