                         SEQUENCE LISTING

<110>  Regennova, Inc.
 
<120>  CYCLIC PEPTIDE COMPOUNDS AND METHODS OF USE

<130>  1185/2 PCT

<150>  US 63/044,493
<151>  2020-06-26

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from Cys, Glu, Asp, Lys, Orn, 2,4-Diaminobutyric 
       Acid (Dab), 2,3-Diaminopropionic Acid (Dap), Ser, Gln, 
       halogenated alanine, and their corresponding enantiomeric D-amino
       acids

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Chemical bond between X3 and X13 is SS-, -CH2-S-CH2 -, -CO-NH-, 
       -CO-O-, -CH2-NH-, -(CH2)n- (n = 2-15), -(CH2)n-CH=CH-(CH2)n- (n =
       2-15), or -S-(CH2)n -R1-(CH2)n -S-, wherein R1 is a hydrocarbon 
       group, an aryl group or a heteroaryl group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is amino iso-butyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is selected from Cys, Glu, Asp, Lys, Orn, 2,4-Diaminobutyric 
       Acid (Dab), 2,3-Diaminopropionic Acid (Dap), Ser, Gln, 
       halogenated alanine, and their corresponding enantiomeric D-amino
       acids

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Chemical bond between X3 and X13 is SS-, -CH2-S-CH2 -, -CO-NH-, 
       -CO-O-, -CH2-NH-, -(CH2)n- (n = 2-15), -(CH2)n-CH=CH-(CH2)n- (n =
       2-15), or -S-(CH2)n -R1-(CH2)n -S-, wherein R1 is a hydrocarbon 
       group, an aryl group or a heteroaryl group

<400>  1

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic contruct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  There is a -SS- chemical bond between residue 3 and 13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<400>  2

Ala Ser Cys Leu Arg Lys Leu Xaa Lys Arg Leu Leu Cys 
1               5                   10              


<210>  3
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Cys is D-Cys and there is a chemical bond between residue 3 and 
       13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<400>  3

Ala Ser Cys Leu Arg Lys Leu Xaa Lys Arg Leu Leu Cys 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Cys is D-Cys and there is a chemical bond between residue 3 and 
       13

<400>  4

Ala Ser Cys Leu Arg Lys Leu Xaa Lys Arg Leu Leu Cys 
1               5                   10              


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Cys is D-Cys and there is a chemical bond between residue 3 and 
       13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Cys is D-Cys and there is a chemical bond between residue 3 and 
       13

<400>  5

Ala Ser Cys Leu Arg Lys Leu Xaa Lys Arg Leu Leu Cys 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is a Lys, Orn, 2,4-Diaminobutyric Acid (Dab), or 
       2,3-Diaminopropionic Acid (Dap) and there is a chemical bond 
       between X3 and X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a Glu or Asp

<400>  6

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is a Glu or Asp and there is a chemical bond between X3 and 
       X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a Lys, Orn, Dab, or Dap

<400>  7

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is a D-Lys, D-Orn, D-Dab, or D-Dap and there is a chemical 
       bond between X3 and X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a Glu or Asp

<400>  8

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is Lys, Orn, Dab, or Dap and there is a chemical bond between 
       X3 and X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a D-Glu or D-Asp

<400>  9

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is D-Lys, D-Orn, D-Dab, or D-Dap and there is a chemical bond 
       between X3 and X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a D-Glu or D-Asp

<400>  10

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is D-Glu or D-Asp and there is a chemical bond between X3 and 
       X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a Lys, Orn, Dab, or Dap

<400>  11

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is a Glu or Asp and there is a chemical bond between X3 and 
       X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a D-Lys, D-Orn, D-Dab, or D-Dap

<400>  12

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  X3 is a D-Glu or D-Asp and there is a chemical bond between X3 
       and X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is a D-Lys, D-Orn, D-Dab, or D-Dap

<400>  13

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Ala is halogenated alanine and there is a chemical bond between 
       X3 and X13

<400>  14

Ala Ser Cys Leu Arg Lys Leu Xaa Lys Arg Leu Leu Ala 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Ala is halogenated D-alanine and there is a chemical bond between
       X3 and X13

<400>  15

Ala Ser Cys Leu Arg Lys Leu Xaa Lys Arg Leu Leu Ala 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Cys is D-Cys and there is a chemical bond between X3 and X13

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Ala is halogenated D-alanine

<400>  16

Ala Ser Cys Leu Arg Lys Leu Xaa Lys Arg Leu Leu Ala 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X3 is selected from Cys, Glu, Asp, Lys, Orn, 2,4-Diaminobutyric 
       Acid (Dab), 2,3-Diaminopropionic Acid (Dap), Ser, Gln, 
       halogenated alanine, and their corresponding enantiomeric D-amino
       acids, or amino iso-butyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is selected from Cys, Glu, Asp, Lys, Orn, 2,4-Diaminobutyric 
       Acid (Dab), 2,3-Diaminopropionic Acid (Dap), Ser, Gln, 
       halogenated alanine, and their corresponding enantiomeric D-amino
       acids, or amino iso-butyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  There is a chemical bond between X3 and X8 or X8 and X13 selected
       from -SS-, -CH2-S-CH2, -CO-NH, -CO-O, -CH2-NH, -(CH2)n (n=2-15), 
       -(CH2)n-CH=CH (CH2)n (n=2-15), or -S-(CH2)n -R1-(CH2)n -S, R1 is 
       a hydrocarbon group, an aryl group or a heteroaryl group n=1-3

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X13 is selected from Cys, Glu, Asp, Lys, Orn, 2,4-Diaminobutyric 
       Acid (Dab), 2,3-Diaminopropionic Acid (Dap), Ser, Gln, 
       halogenated alanine, and their corresponding enantiomeric D-amino
       acids, or amino iso-butyric acid (Aib)

<400>  17

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu Xaa 
1               5                   10              


