                         SEQUENCE LISTING

<110>  The Research Foundation for The State University of New 
       York
 
<120>  5-HALOURACIL-MODIFIED MICRORNAS AND THEIR USE IN THE TREATMENT OF
        CANCER

<130>  34085ZY

<150>  16/912,932
<151>  2020-06-26

<150>  16/176,137
<151>  2018-10-31

<150>  PCT/US2017/059011
<151>  2017-10-30

<150>  62/464,491
<151>  2017-02-28

<150>  62/422,298
<151>  2016-11-15

<150>  62/415,740
<151>  2016-11-01

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1
cuuuuugcgg ucugggcuug c                                                 21


<210>  2
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  2
uagcagcaca uaaugguuug ug                                                22


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified microRNA129 with additional uracils on the 3' end of the
       nucleic acid sequence


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  uracil nucleotides

<400>  3
cuuuuugcgg ucugggcuug cuu                                               23


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-129 nucleic acid with all uracils 
       modified


<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  halouracil nucleotides

<400>  4
cuuuuugcgg ucugggcuug c                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-129 nucleic acid with all uracils 
       in non-seed modified


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  halouracil nucleotides

<400>  5
cuuuuugcgg ucugggcuug c                                                 21


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-15a nucleic acid with all uracils 
       modified


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  halouracil nucleotides

<400>  6
uagcagcaca uaaugguuug ug                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-15a nucleic acid with all uracils 
       in the non-seed portion of the nucleic acid sequence modified


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  halouracil nucleotides

<400>  7
uagcagcaca uaaugguuug ug                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  8
cagugguuuu acccuauggu ag                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-140 nucleic acid with certain 
       uracils modified


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  halouracil nucleotides

<400>  9
cagugguuuu acccuauggu ag                                                22


<210>  10
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  10
cugaccuaug aauugacagc c                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-192 nucleic acid with certain 
       uracils modified


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  halouracil nucleotides

<400>  11
cugaccuaug aauugacagc c                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  12
auccuugcua ucugggugcu a                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-502 nucleic acid with certain 
       uracils modified


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  halouracil nucleotides

<400>  13
auccuugcua ucugggugcu a                                                 21


<210>  14
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  14
uauucaggaa gguguuacuu aa                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-506 nucleic acid with certain 
       uracils modified


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  halouracil nucleotides

<400>  15
uauucaggaa gguguuacuu aa                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-140 nucleic acid with certain 
       uracils modified


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  halouracil nucleotides

<400>  16
cagugguuuu acccuauggu ag                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  17
uggcaguguc uuagcugguu gu                                                22


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-34 nucleic acid with modified 
       uracils


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  halouracil nucleotides

<400>  18
uggcaguguc uuagcugguu gu                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  19
uaacacuguc ugguaacgau gu                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-200a nucleic acid with modified 
       uracils


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  halouracil nucleotides

<400>  20
uaacacuguc ugguaacgau gu                                                22


<210>  21
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  21
uaauacugcc ugguaaugau ga                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-200b nucleic acid with modified 
       uracils


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  halouracil nucleotides

<400>  22
uaauacugcc ugguaaugau ga                                                22


<210>  23
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  23
uaauacugcc ggguaaugau gga                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-200c nucleic acid with modified 
       uracils


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  halouracil nucleotides

<400>  24
uaauacugcc ggguaaugau gga                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  25
guccaguuuu cccaggaauc ccu                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-145 nucleic acid with modified 
       uracils


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  halouracil nucleotides

<400>  26
guccaguuuu cccaggaauc ccu                                               23


<210>  27
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  27
uguaacagca acuccaugug ga                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-194 nucleic acid with modified 
       uracils


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  halouracil nucleotides

<400>  28
uguaacagca acuccaugug ga                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  29
ugagguagua gguuguauag uu                                                22


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-let-7 nucleic acid with modified 
       uracils


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  halouracil nucleotides

<400>  30
ugagguagua gguuguauag uu                                                22


<210>  31
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  31
cgacggcaua uacacuacag ug                                                22


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary modified microRNA-489 nucleic acid in 3' to 5' 
       direction with modified uracils


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  halouracil nucleotides

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  halouracil nucleotides

<400>  32
cgacggcaua uacacuacag ug                                                22


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDC1 3' UTR nucleotide sequence from 5' to 3'

<400>  33
cuaguuucau gcucagaugu cau                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUZ12 3' UTR nucleotide sequence from 5' to 3'

<400>  34
uauaucacuu uuauugaugu cau                                               23


