                         SEQUENCE LISTING

<110>  BRAINBOX SOLUTIONS, INC.
 
<120>  MULTIMODALITY SYSTEMS AND METHODS FOR DETECTION, PROGNOSIS, 
       AND MONITORING OF NEUROLOGICAL INJURY AND DISEASE

<130>  179.0005-WO00

<140>  PCT/US2021/038774
<141>  2021-06-23

<150>  63/042,985
<151>  2020-06-23

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Ala Ser Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Glu Asp Met Ala Ala Phe Met Lys Gly Ala Val Glu Lys 
            20                  25                  30          


Gly Glu Glu Leu Ser Cys Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Gln Arg Ala Ala Trp Arg Val Leu Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Ser Asn Glu Glu Gly Ser Glu Glu Lys Gly Pro Glu 
65                  70                  75                  80  


Val Arg Glu Tyr Arg Glu Lys Val Glu Thr Glu Leu Gln Gly Val Cys 
                85                  90                  95      


Asp Thr Val Leu Gly Leu Leu Asp Ser His Leu Ile Lys Glu Ala Gly 
            100                 105                 110         


Asp Ala Glu Ser Arg Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr 
        115                 120                 125             


Arg Tyr Leu Ala Glu Val Ala Thr Gly Asp Asp Lys Lys Arg Ile Ile 
    130                 135                 140                 


Asp Ser Ala Arg Ser Ala Tyr Gln Glu Ala Met Asp Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Pro Pro Thr Asn Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe His Tyr Glu Ile Ala Asn Ser Pro Glu Glu Ala Ile Ser 
            180                 185                 190         


Leu Ala Lys Thr Thr Phe Asp Glu Ala Met Ala Asp Leu His Thr Leu 
        195                 200                 205             


Ser Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ala Asp Asn Ala Gly Glu Glu Gly Gly 
225                 230                 235                 240 


Glu Ala Pro Gln Glu Pro Gln Ser 
                245             


<210>  2
<211>  1684
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Tyr Trp Asn Leu Glu Lys Arg Asn Cys Val Gln Tyr Arg Arg 
1               5                   10                  15      


His Phe Leu Val Asp Asn Ser Val Phe His Val Glu Arg Cys Met Ser 
            20                  25                  30          


Val Met Gln Ser Gly Thr Gln Met Ile Lys Leu Lys Arg Gly Thr Lys 
        35                  40                  45              


Gly Leu Val Arg Leu Phe Tyr Leu Asp Glu His Arg Thr Arg Leu Arg 
    50                  55                  60                  


Trp Arg Pro Ser Arg Lys Ser Glu Lys Ala Lys Ile Leu Ile Asp Ser 
65                  70                  75                  80  


Ile Tyr Lys Val Thr Glu Gly Arg Gln Ser Glu Ile Phe His Arg Gln 
                85                  90                  95      


Ala Glu Gly Asn Phe Asp Pro Ser Cys Cys Phe Thr Ile Tyr His Gly 
            100                 105                 110         


Asn His Met Glu Ser Leu Asp Leu Ile Thr Ser Asn Pro Glu Glu Ala 
        115                 120                 125             


Arg Thr Trp Ile Thr Gly Leu Lys Tyr Leu Met Ala Gly Ile Ser Asp 
    130                 135                 140                 


Glu Asp Ser Leu Ala Lys Arg Gln Arg Thr His Asp Gln Trp Val Lys 
145                 150                 155                 160 


Gln Thr Phe Glu Glu Ala Asp Lys Asn Gly Asp Gly Leu Leu Asn Ile 
                165                 170                 175     


Glu Glu Ile His Gln Leu Met His Lys Leu Asn Val Asn Leu Pro Arg 
            180                 185                 190         


Arg Lys Val Arg Gln Met Phe Gln Glu Ala Asp Thr Asp Glu Asn Gln 
        195                 200                 205             


Gly Thr Leu Thr Phe Glu Glu Phe Cys Val Phe Tyr Lys Met Met Ser 
    210                 215                 220                 


Leu Arg Arg Asp Leu Tyr Leu Leu Leu Leu Ser Tyr Ser Asp Lys Lys 
225                 230                 235                 240 


Asp His Leu Thr Val Glu Glu Leu Ala Gln Phe Leu Lys Val Glu Gln 
                245                 250                 255     


Lys Met Asn Asn Val Thr Thr Asp Tyr Cys Leu Asp Ile Ile Lys Lys 
            260                 265                 270         


Phe Glu Val Ser Glu Glu Asn Lys Val Lys Asn Val Leu Gly Ile Glu 
        275                 280                 285             


Gly Phe Thr Asn Phe Met Arg Ser Pro Ala Cys Asp Ile Phe Asn Pro 
    290                 295                 300                 


Leu His His Glu Val Tyr Gln Asp Met Asp Gln Pro Leu Cys Asn Tyr 
305                 310                 315                 320 


Tyr Ile Ala Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu Leu 
                325                 330                 335     


Ser Gln Ser Lys Val Asp Met Tyr Ala Arg Val Leu Gln Glu Gly Cys 
            340                 345                 350         


Arg Cys Val Glu Val Asp Cys Trp Asp Gly Pro Asp Gly Glu Pro Val 
        355                 360                 365             


Val His His Gly Tyr Thr Leu Thr Ser Lys Ile Leu Phe Arg Asp Val 
    370                 375                 380                 


Val Glu Thr Ile Asn Lys His Ala Phe Val Lys Asn Glu Phe Pro Val 
385                 390                 395                 400 


Ile Leu Ser Ile Glu Asn His Cys Ser Ile Gln Gln Gln Arg Lys Ile 
                405                 410                 415     


Ala Gln Tyr Leu Lys Gly Ile Phe Gly Asp Lys Leu Asp Leu Ser Ser 
            420                 425                 430         


Val Asp Thr Gly Glu Cys Lys Gln Leu Pro Ser Pro Gln Ser Leu Lys 
        435                 440                 445             


Gly Lys Ile Leu Val Lys Gly Lys Lys Leu Pro Tyr His Leu Gly Asp 
    450                 455                 460                 


Asp Ala Glu Glu Gly Glu Val Ser Asp Glu Asp Ser Ala Asp Glu Ile 
465                 470                 475                 480 


Glu Asp Glu Cys Lys Phe Lys Leu His Tyr Ser Asn Gly Thr Thr Glu 
                485                 490                 495     


His Gln Val Glu Ser Phe Ile Arg Lys Lys Leu Glu Ser Leu Leu Lys 
            500                 505                 510         


Glu Ser Gln Ile Arg Asp Lys Glu Asp Pro Asp Ser Phe Thr Val Arg 
        515                 520                 525             


Ala Leu Leu Lys Ala Thr His Glu Gly Leu Asn Ala His Leu Lys Gln 
    530                 535                 540                 


Ser Pro Asp Val Lys Glu Ser Gly Lys Lys Ser His Gly Arg Ser Leu 
545                 550                 555                 560 


Met Thr Asn Phe Gly Lys His Lys Lys Thr Thr Lys Ser Arg Ser Lys 
                565                 570                 575     


Ser Tyr Ser Thr Asp Asp Glu Glu Asp Thr Gln Gln Ser Thr Gly Lys 
            580                 585                 590         


Glu Gly Gly Gln Leu Tyr Arg Leu Gly Arg Arg Arg Lys Thr Met Lys 
        595                 600                 605             


Leu Cys Arg Glu Leu Ser Asp Leu Val Val Tyr Thr Asn Ser Val Ala 
    610                 615                 620                 


Ala Gln Asp Ile Val Asp Asp Gly Thr Thr Gly Asn Val Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Thr Arg Ala His Gln Val Val Gln Gln Lys Ser Glu Gln Phe 
                645                 650                 655     


Met Ile Tyr Asn Gln Lys Gln Leu Thr Arg Ile Tyr Pro Ser Ala Tyr 
            660                 665                 670         


Arg Ile Asp Ser Ser Asn Phe Asn Pro Leu Pro Tyr Trp Asn Ala Gly 
        675                 680                 685             


Cys Gln Leu Val Ala Leu Asn Tyr Gln Ser Glu Gly Arg Met Met Gln 
    690                 695                 700                 


Leu Asn Arg Ala Lys Phe Lys Ala Asn Gly Asn Cys Gly Tyr Val Leu 
705                 710                 715                 720 


Lys Pro Gln Gln Met Cys Lys Gly Thr Phe Asn Pro Phe Ser Gly Asp 
                725                 730                 735     


Pro Leu Pro Ala Asn Pro Lys Lys Gln Leu Ile Leu Lys Val Ile Ser 
            740                 745                 750         


Gly Gln Gln Leu Pro Lys Pro Pro Asp Ser Met Phe Gly Asp Arg Gly 
        755                 760                 765             


Glu Ile Ile Asp Pro Phe Val Glu Val Glu Ile Ile Gly Leu Pro Val 
    770                 775                 780                 


Asp Cys Cys Lys Asp Gln Thr Arg Val Val Asp Asp Asn Gly Phe Asn 
785                 790                 795                 800 


Pro Val Trp Glu Glu Thr Leu Thr Phe Thr Val His Met Pro Glu Ile 
                805                 810                 815     


Ala Leu Val Arg Phe Leu Val Trp Asp His Asp Pro Ile Gly Arg Asp 
            820                 825                 830         


Phe Val Gly Gln Arg Thr Val Thr Phe Ser Ser Leu Val Pro Gly Tyr 
        835                 840                 845             


Arg His Val Tyr Leu Glu Gly Leu Thr Glu Ala Ser Ile Phe Val His 
    850                 855                 860                 


Ile Thr Ile Asn Glu Ile Tyr Gly Lys Asn Arg Gln Leu Gln Gly Leu 
865                 870                 875                 880 


Lys Gly Leu Phe Asn Lys Asn Pro Arg His Ser Ser Ser Glu Asn Asn 
                885                 890                 895     


Ser His Tyr Val Arg Lys Arg Ser Ile Gly Asp Arg Ile Leu Arg Arg 
            900                 905                 910         


Thr Ala Ser Ala Pro Ala Lys Gly Arg Lys Lys Ser Lys Met Gly Phe 
        915                 920                 925             


Gln Glu Met Val Glu Ile Lys Asp Ser Val Ser Glu Ala Thr Arg Asp 
    930                 935                 940                 


Gln Asp Gly Val Leu Arg Arg Thr Thr Arg Ser Leu Gln Ala Arg Pro 
945                 950                 955                 960 


Val Ser Met Pro Val Asp Arg Asn Leu Leu Gly Ala Leu Ser Leu Pro 
                965                 970                 975     


Val Ser Glu Thr Ala Lys Asp Ile Glu Gly Lys Glu Asn Ser Leu Glu 
            980                 985                 990         


Asp Lys Asp Gly Arg Arg Lys Gly  Lys Ala Ser Ile Lys  Asp Pro His 
        995                 1000                 1005             


Phe Leu  Asn Phe Asn Lys Lys  Leu Ser Ser Ser Ser  Ser Ala Leu 
    1010                 1015                 1020             


Leu His  Lys Asp Thr Ser Gln  Gly Asp Thr Ile Val  Ser Thr Ala 
    1025                 1030                 1035             


His Met  Ser Val Thr Gly Glu  Gln Leu Gly Met Ser  Ser Pro Arg 
    1040                 1045                 1050             


Gly Gly  Arg Thr Thr Ser Asn  Ala Thr Ser Asn Cys  Gln Glu Asn 
    1055                 1060                 1065             


Pro Cys  Pro Ser Lys Ser Leu  Ser Pro Lys Gln His  Leu Ala Pro 
    1070                 1075                 1080             


Asp Pro  Val Val Asn Pro Thr  Gln Asp Leu His Gly  Val Lys Ile 
    1085                 1090                 1095             


Lys Glu  Lys Gly Asn Pro Glu  Asp Phe Val Glu Gly  Lys Ser Ile 
    1100                 1105                 1110             


Leu Ser  Gly Ser Val Leu Ser  His Ser Asn Leu Glu  Ile Lys Asn 
    1115                 1120                 1125             


Leu Glu  Gly Asn Arg Gly Lys  Gly Arg Ala Ala Thr  Ser Phe Ser 
    1130                 1135                 1140             


Leu Ser  Asp Val Ser Met Leu  Cys Ser Asp Ile Pro  Asp Leu His 
    1145                 1150                 1155             


Ser Thr  Ala Ile Leu Gln Glu  Ser Val Ile Ser His  Leu Ile Asp 
    1160                 1165                 1170             


Asn Val  Thr Leu Thr Asn Glu  Asn Glu Pro Gly Ser  Ser Ile Ser 
    1175                 1180                 1185             


Ala Leu  Ile Gly Gln Phe Asp  Glu Thr Asn Asn Gln  Ala Leu Thr 
    1190                 1195                 1200             


Val Val  Ser His Leu His Asn  Thr Ser Val Met Ser  Gly His Cys 
    1205                 1210                 1215             


Pro Leu  Pro Ser Leu Gly Leu  Lys Met Pro Ile Lys  His Gly Phe 
    1220                 1225                 1230             


Cys Lys  Gly Lys Ser Lys Ser  Ser Phe Leu Cys Ser  Ser Pro Glu 
    1235                 1240                 1245             


Leu Ile  Ala Leu Ser Ser Ser  Glu Thr Thr Lys His  Ala Thr Asn 
    1250                 1255                 1260             


Thr Val  Tyr Glu Thr Thr Cys  Thr Pro Ile Ser Lys  Thr Lys Pro 
    1265                 1270                 1275             


Asp Asp  Asp Leu Ser Ser Lys  Ala Lys Thr Ala Ala  Leu Glu Ser 
    1280                 1285                 1290             


Asn Leu  Pro Gly Ser Pro Asn  Thr Ser Arg Gly Trp  Leu Pro Lys 
    1295                 1300                 1305             


Ser Pro  Thr Lys Gly Glu Asp  Trp Glu Thr Leu Lys  Ser Cys Ser 
    1310                 1315                 1320             


Pro Ala  Ser Ser Pro Asp Leu  Thr Leu Glu Asp Val  Ile Ala Asp 
    1325                 1330                 1335             


Pro Thr  Leu Cys Phe Asn Ser  Gly Glu Ser Ser Leu  Val Glu Ile 
    1340                 1345                 1350             


Asp Gly  Glu Ser Glu Asn Leu  Ser Leu Thr Thr Cys  Glu Tyr Arg 
    1355                 1360                 1365             


Arg Glu  Gly Thr Ser Gln Leu  Ala Ser Pro Leu Lys  Leu Lys Tyr 
    1370                 1375                 1380             


Asn Gln  Gly Val Val Glu His  Phe Gln Arg Gly Leu  Arg Asn Gly 
    1385                 1390                 1395             


Tyr Cys  Lys Glu Thr Leu Arg  Pro Ser Val Pro Glu  Ile Phe Asn 
    1400                 1405                 1410             


Asn Ile  Gln Asp Val Lys Thr  Gln Ser Ile Ser Tyr  Leu Ala Tyr 
    1415                 1420                 1425             


Gln Gly  Ala Gly Phe Val His  Asn His Phe Ser Asp  Ser Asp Ala 
    1430                 1435                 1440             


Lys Met  Phe Gln Thr Cys Val  Pro Gln Gln Ser Ser  Ala Gln Asp 
    1445                 1450                 1455             


Met His  Val Pro Val Pro Lys  Gln Leu Ala His Leu  Pro Leu Pro 
    1460                 1465                 1470             


Ala Leu  Lys Leu Pro Ser Pro  Cys Lys Ser Lys Ser  Leu Gly Asp 
    1475                 1480                 1485             


Leu Thr  Ser Glu Asp Ile Ala  Cys Asn Phe Glu Ser  Lys Tyr Gln 
    1490                 1495                 1500             


Cys Ile  Ser Lys Ser Phe Val  Thr Thr Gly Ile Arg  Asp Lys Lys 
    1505                 1510                 1515             


Gly Val  Thr Val Lys Thr Lys  Ser Leu Glu Pro Ile  Asp Ala Leu 
    1520                 1525                 1530             


Thr Glu  Gln Leu Arg Lys Leu  Val Ser Phe Asp Gln  Glu Asp Asn 
    1535                 1540                 1545             


Cys Gln  Val Leu Tyr Ser Lys  Gln Asp Ala Asn Gln  Leu Pro Arg 
    1550                 1555                 1560             


Ala Leu  Val Arg Lys Leu Ser  Ser Arg Ser Gln Ser  Arg Val Arg 
    1565                 1570                 1575             


Asn Ile  Ala Ser Arg Ala Lys  Glu Lys Gln Glu Ala  Asn Lys Gln 
    1580                 1585                 1590             


Lys Val  Pro Asn Pro Ser Asn  Gly Ala Gly Val Val  Leu Arg Asn 
    1595                 1600                 1605             


Lys Pro  Ser Ala Pro Thr Pro  Ala Val Asn Arg His  Ser Thr Gly 
    1610                 1615                 1620             


Ser Tyr  Ile Ala Gly Tyr Leu  Lys Asn Thr Lys Gly  Gly Gly Leu 
    1625                 1630                 1635             


Glu Gly  Arg Gly Ile Pro Glu  Gly Ala Cys Thr Ala  Leu His Tyr 
    1640                 1645                 1650             


Gly His  Val Asp Gln Phe Cys  Ser Asp Asn Ser Val  Leu Gln Thr 
    1655                 1660                 1665             


Glu Pro  Ser Ser Asp Asp Lys  Pro Glu Ile Tyr Phe  Leu Leu Arg 
    1670                 1675                 1680             


Leu 
    


<210>  3
<211>  2436
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Phe Leu His Gln Leu Gln Leu Leu Leu Trp Lys Asn Val Thr 
1               5                   10                  15      


Leu Lys Arg Arg Ser Pro Trp Val Leu Ala Phe Glu Ile Phe Ile Pro 
            20                  25                  30          


Leu Val Leu Phe Phe Ile Leu Leu Gly Leu Arg Gln Lys Lys Pro Thr 
        35                  40                  45              


Ile Ser Val Lys Glu Val Ser Phe Tyr Thr Ala Ala Pro Leu Thr Ser 
    50                  55                  60                  


Ala Gly Ile Leu Pro Val Met Gln Ser Leu Cys Pro Asp Gly Gln Arg 
65                  70                  75                  80  


Asp Glu Phe Gly Phe Leu Gln Tyr Ala Asn Ser Thr Val Thr Gln Leu 
                85                  90                  95      


Leu Glu Arg Leu Asp Arg Val Val Glu Glu Gly Asn Leu Phe Asp Pro 
            100                 105                 110         


Ala Arg Pro Ser Leu Gly Ser Glu Leu Glu Ala Leu Arg Gln His Leu 
        115                 120                 125             


Glu Ala Leu Ser Ala Gly Pro Gly Thr Ser Gly Ser His Leu Asp Arg 
    130                 135                 140                 


Ser Thr Val Ser Ser Phe Ser Leu Asp Ser Val Ala Arg Asn Pro Gln 
145                 150                 155                 160 


Glu Leu Trp Arg Phe Leu Thr Gln Asn Leu Ser Leu Pro Asn Ser Thr 
                165                 170                 175     


Ala Gln Ala Leu Leu Ala Ala Arg Val Asp Pro Pro Glu Val Tyr His 
            180                 185                 190         


Leu Leu Phe Gly Pro Ser Ser Ala Leu Asp Ser Gln Ser Gly Leu His 
        195                 200                 205             


Lys Gly Gln Glu Pro Trp Ser Arg Leu Gly Gly Asn Pro Leu Phe Arg 
    210                 215                 220                 


Met Glu Glu Leu Leu Leu Ala Pro Ala Leu Leu Glu Gln Leu Thr Cys 
225                 230                 235                 240 


Thr Pro Gly Ser Gly Glu Leu Gly Arg Ile Leu Thr Val Pro Glu Ser 
                245                 250                 255     


Gln Lys Gly Ala Leu Gln Gly Tyr Arg Asp Ala Val Cys Ser Gly Gln 
            260                 265                 270         


Ala Ala Ala Arg Ala Arg Arg Phe Ser Gly Leu Ser Ala Glu Leu Arg 
        275                 280                 285             


Asn Gln Leu Asp Val Ala Lys Val Ser Gln Gln Leu Gly Leu Asp Ala 
    290                 295                 300                 


Pro Asn Gly Ser Asp Ser Ser Pro Gln Ala Pro Pro Pro Arg Arg Leu 
305                 310                 315                 320 


Gln Ala Leu Leu Gly Asp Leu Leu Asp Ala Gln Lys Val Leu Gln Asp 
                325                 330                 335     


Val Asp Val Leu Ser Ala Leu Ala Leu Leu Leu Pro Gln Gly Ala Cys 
            340                 345                 350         


Thr Gly Arg Thr Pro Gly Pro Pro Ala Ser Gly Ala Gly Gly Ala Ala 
        355                 360                 365             


Asn Gly Thr Gly Ala Gly Ala Val Met Gly Pro Asn Ala Thr Ala Glu 
    370                 375                 380                 


Glu Gly Ala Pro Ser Ala Ala Ala Leu Ala Thr Pro Asp Thr Leu Gln 
385                 390                 395                 400 


Gly Gln Cys Ser Ala Phe Val Gln Leu Trp Ala Gly Leu Gln Pro Ile 
                405                 410                 415     


Leu Cys Gly Asn Asn Arg Thr Ile Glu Pro Glu Ala Leu Arg Arg Gly 
            420                 425                 430         


Asn Met Ser Ser Leu Gly Phe Thr Ser Lys Glu Gln Arg Asn Leu Gly 
        435                 440                 445             


Leu Leu Val His Leu Met Thr Ser Asn Pro Lys Ile Leu Tyr Ala Pro 
    450                 455                 460                 


Ala Gly Ser Glu Val Asp Arg Val Ile Leu Lys Ala Asn Glu Thr Phe 
465                 470                 475                 480 


Ala Phe Val Gly Asn Val Thr His Tyr Ala Gln Val Trp Leu Asn Ile 
                485                 490                 495     


Ser Ala Glu Ile Arg Ser Phe Leu Glu Gln Gly Arg Leu Gln Gln His 
            500                 505                 510         


Leu Arg Trp Leu Gln Gln Tyr Val Ala Glu Leu Arg Leu His Pro Glu 
        515                 520                 525             


Ala Leu Asn Leu Ser Leu Asp Glu Leu Pro Pro Ala Leu Arg Gln Asp 
    530                 535                 540                 


Asn Phe Ser Leu Pro Ser Gly Met Ala Leu Leu Gln Gln Leu Asp Thr 
545                 550                 555                 560 


Ile Asp Asn Ala Ala Cys Gly Trp Ile Gln Phe Met Ser Lys Val Ser 
                565                 570                 575     


Val Asp Ile Phe Lys Gly Phe Pro Asp Glu Glu Ser Ile Val Asn Tyr 
            580                 585                 590         


Thr Leu Asn Gln Ala Tyr Gln Asp Asn Val Thr Val Phe Ala Ser Val 
        595                 600                 605             


Ile Phe Gln Thr Arg Lys Asp Gly Ser Leu Pro Pro His Val His Tyr 
    610                 615                 620                 


Lys Ile Arg Gln Asn Ser Ser Phe Thr Glu Lys Thr Asn Glu Ile Arg 
625                 630                 635                 640 


Arg Ala Tyr Trp Arg Pro Gly Pro Asn Thr Gly Gly Arg Phe Tyr Phe 
                645                 650                 655     


Leu Tyr Gly Phe Val Trp Ile Gln Asp Met Met Glu Arg Ala Ile Ile 
            660                 665                 670         


Asp Thr Phe Val Gly His Asp Val Val Glu Pro Gly Ser Tyr Val Gln 
        675                 680                 685             


Met Phe Pro Tyr Pro Cys Tyr Thr Arg Asp Asp Phe Leu Phe Val Ile 
    690                 695                 700                 


Glu His Met Met Pro Leu Cys Met Val Ile Ser Trp Val Tyr Ser Val 
705                 710                 715                 720 


Ala Met Thr Ile Gln His Ile Val Ala Glu Lys Glu His Arg Leu Lys 
                725                 730                 735     


Glu Val Met Lys Thr Met Gly Leu Asn Asn Ala Val His Trp Val Ala 
            740                 745                 750         


Trp Phe Ile Thr Gly Phe Val Gln Leu Ser Ile Ser Val Thr Ala Leu 
        755                 760                 765             


Thr Ala Ile Leu Lys Tyr Gly Gln Val Leu Met His Ser His Val Val 
    770                 775                 780                 


Ile Ile Trp Leu Phe Leu Ala Val Tyr Ala Val Ala Thr Ile Met Phe 
785                 790                 795                 800 


Cys Phe Leu Val Ser Val Leu Tyr Ser Lys Ala Lys Leu Ala Ser Ala 
                805                 810                 815     


Cys Gly Gly Ile Ile Tyr Phe Leu Ser Tyr Val Pro Tyr Met Tyr Val 
            820                 825                 830         


Ala Ile Arg Glu Glu Val Ala His Asp Lys Ile Thr Ala Phe Glu Lys 
        835                 840                 845             


Cys Ile Ala Ser Leu Met Ser Thr Thr Ala Phe Gly Leu Gly Ser Lys 
    850                 855                 860                 


Tyr Phe Ala Leu Tyr Glu Val Ala Gly Val Gly Ile Gln Trp His Thr 
865                 870                 875                 880 


Phe Ser Gln Ser Pro Val Glu Gly Asp Asp Phe Asn Leu Leu Leu Ala 
                885                 890                 895     


Val Thr Met Leu Met Val Asp Ala Val Val Tyr Gly Ile Leu Thr Trp 
            900                 905                 910         


Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly Leu Pro Arg Pro Trp 
        915                 920                 925             


Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly Ser Gly Arg Thr Glu 
    930                 935                 940                 


Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr Pro Arg Leu Ser Val 
945                 950                 955                 960 


Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser Arg Arg Phe Glu Glu 
                965                 970                 975     


Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu Pro Leu Val Val Cys 
            980                 985                 990         


Val Asp Lys Leu Thr Lys Val Tyr  Lys Asp Asp Lys Lys  Leu Ala Leu 
        995                 1000                 1005             


Asn Lys  Leu Ser Leu Asn Leu  Tyr Glu Asn Gln Val  Val Ser Phe 
    1010                 1015                 1020             


Leu Gly  His Asn Gly Ala Gly  Lys Thr Thr Thr Met  Ser Ile Leu 
    1025                 1030                 1035             


Thr Gly  Leu Phe Pro Pro Thr  Ser Gly Ser Ala Thr  Ile Tyr Gly 
    1040                 1045                 1050             


His Asp  Ile Arg Thr Glu Met  Asp Glu Ile Arg Lys  Asn Leu Gly 
    1055                 1060                 1065             


Met Cys  Pro Gln His Asn Val  Leu Phe Asp Arg Leu  Thr Val Glu 
    1070                 1075                 1080             


Glu His  Leu Trp Phe Tyr Ser  Arg Leu Lys Ser Met  Ala Gln Glu 
    1085                 1090                 1095             


Glu Ile  Arg Arg Glu Met Asp  Lys Met Ile Glu Asp  Leu Glu Leu 
    1100                 1105                 1110             


Ser Asn  Lys Arg His Ser Leu  Val Gln Thr Leu Ser  Gly Gly Met 
    1115                 1120                 1125             


Lys Arg  Lys Leu Ser Val Ala  Ile Ala Phe Val Gly  Gly Ser Arg 
    1130                 1135                 1140             


Ala Ile  Ile Leu Asp Glu Pro  Thr Ala Gly Val Asp  Pro Tyr Ala 
    1145                 1150                 1155             


Arg Arg  Ala Ile Trp Asp Leu  Ile Leu Lys Tyr Lys  Pro Gly Arg 
    1160                 1165                 1170             


Thr Ile  Leu Leu Ser Thr His  His Met Asp Glu Ala  Asp Leu Leu 
    1175                 1180                 1185             


Gly Asp  Arg Ile Ala Ile Ile  Ser His Gly Lys Leu  Lys Cys Cys 
    1190                 1195                 1200             


Gly Ser  Pro Leu Phe Leu Lys  Gly Thr Tyr Gly Asp  Gly Tyr Arg 
    1205                 1210                 1215             


Leu Thr  Leu Val Lys Arg Pro  Ala Glu Pro Gly Gly  Pro Gln Glu 
    1220                 1225                 1230             


Pro Gly  Leu Ala Ser Ser Pro  Pro Gly Arg Ala Pro  Leu Ser Ser 
    1235                 1240                 1245             


Cys Ser  Glu Leu Gln Val Ser  Gln Phe Ile Arg Lys  His Val Ala 
    1250                 1255                 1260             


Ser Cys  Leu Leu Val Ser Asp  Thr Ser Thr Glu Leu  Ser Tyr Ile 
    1265                 1270                 1275             


Leu Pro  Ser Glu Ala Ala Lys  Lys Gly Ala Phe Glu  Arg Leu Phe 
    1280                 1285                 1290             


Gln His  Leu Glu Arg Ser Leu  Asp Ala Leu His Leu  Ser Ser Phe 
    1295                 1300                 1305             


Gly Leu  Met Asp Thr Thr Leu  Glu Glu Val Phe Leu  Lys Val Ser 
    1310                 1315                 1320             


Glu Glu  Asp Gln Ser Leu Glu  Asn Ser Glu Ala Asp  Val Lys Glu 
    1325                 1330                 1335             


Ser Arg  Lys Asp Val Leu Pro  Gly Ala Glu Gly Pro  Ala Ser Gly 
    1340                 1345                 1350             


Glu Gly  His Ala Gly Asn Leu  Ala Arg Cys Ser Glu  Leu Thr Gln 
    1355                 1360                 1365             


Ser Gln  Ala Ser Leu Gln Ser  Ala Ser Ser Val Gly  Ser Ala Arg 
    1370                 1375                 1380             


Gly Asp  Glu Gly Ala Gly Tyr  Thr Asp Val Tyr Gly  Asp Tyr Arg 
    1385                 1390                 1395             


Pro Leu  Phe Asp Asn Pro Gln  Asp Pro Asp Asn Val  Ser Leu Gln 
    1400                 1405                 1410             


Glu Val  Glu Ala Glu Ala Leu  Ser Arg Val Gly Gln  Gly Ser Arg 
    1415                 1420                 1425             


Lys Leu  Asp Gly Gly Trp Leu  Lys Val Arg Gln Phe  His Gly Leu 
    1430                 1435                 1440             


Leu Val  Lys Arg Phe His Cys  Ala Arg Arg Asn Ser  Lys Ala Leu 
    1445                 1450                 1455             


Phe Ser  Gln Ile Leu Leu Pro  Ala Phe Phe Val Cys  Val Ala Met 
    1460                 1465                 1470             


Thr Val  Ala Leu Ser Val Pro  Glu Ile Gly Asp Leu  Pro Pro Leu 
    1475                 1480                 1485             


Val Leu  Ser Pro Ser Gln Tyr  His Asn Tyr Thr Gln  Pro Arg Gly 
    1490                 1495                 1500             


Asn Phe  Ile Pro Tyr Ala Asn  Glu Glu Arg Arg Glu  Tyr Arg Leu 
    1505                 1510                 1515             


Arg Leu  Ser Pro Asp Ala Ser  Pro Gln Gln Leu Val  Ser Thr Phe 
    1520                 1525                 1530             


Arg Leu  Pro Ser Gly Val Gly  Ala Thr Cys Val Leu  Lys Ser Pro 
    1535                 1540                 1545             


Ala Asn  Gly Ser Leu Gly Pro  Thr Leu Asn Leu Ser  Ser Gly Glu 
    1550                 1555                 1560             


Ser Arg  Leu Leu Ala Ala Arg  Phe Phe Asp Ser Met  Cys Leu Glu 
    1565                 1570                 1575             


Ser Phe  Thr Gln Gly Leu Pro  Leu Ser Asn Phe Val  Pro Pro Pro 
    1580                 1585                 1590             


Pro Ser  Pro Ala Pro Ser Asp  Ser Pro Ala Ser Pro  Asp Glu Asp 
    1595                 1600                 1605             


Leu Gln  Ala Trp Asn Val Ser  Leu Pro Pro Thr Ala  Gly Pro Glu 
    1610                 1615                 1620             


Met Trp  Thr Ser Ala Pro Ser  Leu Pro Arg Leu Val  Arg Glu Pro 
    1625                 1630                 1635             


Val Arg  Cys Thr Cys Ser Ala  Gln Gly Thr Gly Phe  Ser Cys Pro 
    1640                 1645                 1650             


Ser Ser  Val Gly Gly His Pro  Pro Gln Met Arg Val  Val Thr Gly 
    1655                 1660                 1665             


Asp Ile  Leu Thr Asp Ile Thr  Gly His Asn Val Ser  Glu Tyr Leu 
    1670                 1675                 1680             


Leu Phe  Thr Ser Asp Arg Phe  Arg Leu His Arg Tyr  Gly Ala Ile 
    1685                 1690                 1695             


Thr Phe  Gly Asn Val Leu Lys  Ser Ile Pro Ala Ser  Phe Gly Thr 
    1700                 1705                 1710             


Arg Ala  Pro Pro Met Val Arg  Lys Ile Ala Val Arg  Arg Ala Ala 
    1715                 1720                 1725             


Gln Val  Phe Tyr Asn Asn Lys  Gly Tyr His Ser Met  Pro Thr Tyr 
    1730                 1735                 1740             


Leu Asn  Ser Leu Asn Asn Ala  Ile Leu Arg Ala Asn  Leu Pro Lys 
    1745                 1750                 1755             


Ser Lys  Gly Asn Pro Ala Ala  Tyr Gly Ile Thr Val  Thr Asn His 
    1760                 1765                 1770             


Pro Met  Asn Lys Thr Ser Ala  Ser Leu Ser Leu Asp  Tyr Leu Leu 
    1775                 1780                 1785             


Gln Gly  Thr Asp Val Val Ile  Ala Ile Phe Ile Ile  Val Ala Met 
    1790                 1795                 1800             


Ser Phe  Val Pro Ala Ser Phe  Val Val Phe Leu Val  Ala Glu Lys 
    1805                 1810                 1815             


Ser Thr  Lys Ala Lys His Leu  Gln Phe Val Ser Gly  Cys Asn Pro 
    1820                 1825                 1830             


Ile Ile  Tyr Trp Leu Ala Asn  Tyr Val Trp Asp Met  Leu Asn Tyr 
    1835                 1840                 1845             


Leu Val  Pro Ala Thr Cys Cys  Val Ile Ile Leu Phe  Val Phe Asp 
    1850                 1855                 1860             


Leu Pro  Ala Tyr Thr Ser Pro  Thr Asn Phe Pro Ala  Val Leu Ser 
    1865                 1870                 1875             


Leu Phe  Leu Leu Tyr Gly Trp  Ser Ile Thr Pro Ile  Met Tyr Pro 
    1880                 1885                 1890             


Ala Ser  Phe Trp Phe Glu Val  Pro Ser Ser Ala Tyr  Val Phe Leu 
    1895                 1900                 1905             


Ile Val  Ile Asn Leu Phe Ile  Gly Ile Thr Ala Thr  Val Ala Thr 
    1910                 1915                 1920             


Phe Leu  Leu Gln Leu Phe Glu  His Asp Lys Asp Leu  Lys Val Val 
    1925                 1930                 1935             


Asn Ser  Tyr Leu Lys Ser Cys  Phe Leu Ile Phe Pro  Asn Tyr Asn 
    1940                 1945                 1950             


Leu Gly  His Gly Leu Met Glu  Met Ala Tyr Asn Glu  Tyr Ile Asn 
    1955                 1960                 1965             


Glu Tyr  Tyr Ala Lys Ile Gly  Gln Phe Asp Lys Met  Lys Ser Pro 
    1970                 1975                 1980             


Phe Glu  Trp Asp Ile Val Thr  Arg Gly Leu Val Ala  Met Ala Val 
    1985                 1990                 1995             


Glu Gly  Val Val Gly Phe Leu  Leu Thr Ile Met Cys  Gln Tyr Asn 
    2000                 2005                 2010             


Phe Leu  Arg Arg Pro Gln Arg  Met Pro Val Ser Thr  Lys Pro Val 
    2015                 2020                 2025             


Glu Asp  Asp Val Asp Val Ala  Ser Glu Arg Gln Arg  Val Leu Arg 
    2030                 2035                 2040             


Gly Asp  Ala Asp Asn Asp Met  Val Lys Ile Glu Asn  Leu Thr Lys 
    2045                 2050                 2055             


Val Tyr  Lys Ser Arg Lys Ile  Gly Arg Ile Leu Ala  Val Asp Arg 
    2060                 2065                 2070             


Leu Cys  Leu Gly Val Arg Pro  Gly Glu Cys Phe Gly  Leu Leu Gly 
    2075                 2080                 2085             


Val Asn  Gly Ala Gly Lys Thr  Ser Thr Phe Lys Met  Leu Thr Gly 
    2090                 2095                 2100             


Asp Glu  Ser Thr Thr Gly Gly  Glu Ala Phe Val Asn  Gly His Ser 
    2105                 2110                 2115             


Val Leu  Lys Glu Leu Leu Gln  Val Gln Gln Ser Leu  Gly Tyr Cys 
    2120                 2125                 2130             


Pro Gln  Cys Asp Ala Leu Phe  Asp Glu Leu Thr Ala  Arg Glu His 
    2135                 2140                 2145             


Leu Gln  Leu Tyr Thr Arg Leu  Arg Gly Ile Ser Trp  Lys Asp Glu 
    2150                 2155                 2160             


Ala Arg  Val Val Lys Trp Ala  Leu Glu Lys Leu Glu  Leu Thr Lys 
    2165                 2170                 2175             


Tyr Ala  Asp Lys Pro Ala Gly  Thr Tyr Ser Gly Gly  Asn Lys Arg 
    2180                 2185                 2190             


Lys Leu  Ser Thr Ala Ile Ala  Leu Ile Gly Tyr Pro  Ala Phe Ile 
    2195                 2200                 2205             


Phe Leu  Asp Glu Pro Thr Thr  Gly Met Asp Pro Lys  Ala Arg Arg 
    2210                 2215                 2220             


Phe Leu  Trp Asn Leu Ile Leu  Asp Leu Ile Lys Thr  Gly Arg Ser 
    2225                 2230                 2235             


Val Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    2240                 2245                 2250             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Arg Leu Arg  Cys Leu Gly 
    2255                 2260                 2265             


Ser Ile  Gln His Leu Lys Asn  Arg Phe Gly Asp Gly  Tyr Met Ile 
    2270                 2275                 2280             


Thr Val  Arg Thr Lys Ser Ser  Gln Ser Val Lys Asp  Val Val Arg 
    2285                 2290                 2295             


Phe Phe  Asn Arg Asn Phe Pro  Glu Ala Met Leu Lys  Glu Arg His 
    2300                 2305                 2310             


His Thr  Lys Val Gln Tyr Gln  Leu Lys Ser Glu His  Ile Ser Leu 
    2315                 2320                 2325             


Ala Gln  Val Phe Ser Lys Met  Glu Gln Val Ser Gly  Val Leu Gly 
    2330                 2335                 2340             


Ile Glu  Asp Tyr Ser Val Ser  Gln Thr Thr Leu Asp  Asn Val Phe 
    2345                 2350                 2355             


Val Asn  Phe Ala Lys Lys Gln  Ser Asp Asn Leu Glu  Gln Gln Glu 
    2360                 2365                 2370             


Thr Glu  Pro Pro Ser Ala Leu  Gln Ser Pro Leu Gly  Cys Leu Leu 
    2375                 2380                 2385             


Ser Leu  Leu Arg Pro Arg Ser  Ala Pro Thr Glu Leu  Arg Ala Leu 
    2390                 2395                 2400             


Val Ala  Asp Glu Pro Glu Asp  Leu Asp Thr Glu Asp  Glu Gly Leu 
    2405                 2410                 2415             


Ile Ser  Phe Glu Glu Glu Arg  Ala Gln Leu Ser Phe  Asn Thr Asp 
    2420                 2425                 2430             


Thr Leu  Cys 
    2435     


<210>  4
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  5
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Leu Phe Gly Phe Gly Ser Arg Arg Gly Gln Thr Ala Gln Gly 
1               5                   10                  15      


Ser Ile Asp His Val Tyr Thr Gly Ser Gly Tyr Arg Ile Arg Asp Ser 
            20                  25                  30          


Glu Leu Gln Lys Ile His Arg Ala Ala Val Lys Gly Asp Ala Ala Glu 
        35                  40                  45              


Val Glu Arg Cys Leu Ala Arg Arg Ser Gly Glu Leu Asp Ala Leu Asp 
    50                  55                  60                  


Lys Gln His Arg Thr Ala Leu His Leu Ala Cys Ala Ser Gly His Val 
65                  70                  75                  80  


Gln Val Val Thr Leu Leu Val Asn Arg Lys Cys Gln Ile Asp Val Cys 
                85                  90                  95      


Asp Lys Glu Asn Arg Thr Pro Leu Ile Gln Ala Val His Cys Gln Glu 
            100                 105                 110         


Glu Ala Cys Ala Val Ile Leu Leu Glu His Gly Ala Asn Pro Asn Leu 
        115                 120                 125             


Lys Asp Ile Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Ser Glu 
    130                 135                 140                 


Ser Thr Ser Leu Ala Glu Lys Leu Leu Ser His Gly Ala His Ile Glu 
145                 150                 155                 160 


Ala Leu Asp Lys Asp Asn Asn Thr Pro Leu Leu Phe Ala Ile Ile Cys 
                165                 170                 175     


Lys Lys Glu Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Ser Ser 
            180                 185                 190         


His Ala Val Asp Arg Leu Arg Arg Ser Ala Leu Met Leu Ala Val Tyr 
        195                 200                 205             


Tyr Asp Ser Pro Gly Ile Val Asn Ile Leu Leu Lys Gln Asn Ile Asp 
    210                 215                 220                 


Val Phe Ala Gln Asp Met Cys Gly Arg Asp Ala Glu Asp Tyr Ala Ile 
225                 230                 235                 240 


Ser His His Leu Thr Lys Ile Gln Gln Gln Ile Leu Glu His Lys Lys 
                245                 250                 255     


Lys Ile Leu Lys Lys Glu Lys Ser Asp Val Gly Ser Ser Asp Glu Ser 
            260                 265                 270         


Ala Val Ser Ile Phe His Glu Leu Arg Val Asp Ser Leu Pro Ala Ser 
        275                 280                 285             


Asp Asp Lys Asp Leu Asn Val Ala Thr Lys Gln Cys Val Pro Glu Lys 
    290                 295                 300                 


Val Ser Glu Pro Leu Pro Gly Ser Ser His Glu Lys Gly Asn Arg Ile 
305                 310                 315                 320 


Val Asn Gly Gln Gly Glu Gly Pro Pro Ala Lys His Pro Ser Leu Lys 
                325                 330                 335     


Pro Ser Thr Glu Val Glu Asp Pro Ala Val Lys Gly Ala Val Gln Arg 
            340                 345                 350         


Lys Asn Val Gln Thr Leu Arg Ala Glu Gln Ala Leu Pro Val Ala Ser 
        355                 360                 365             


Glu Glu Glu Gln Gln Arg His Glu Arg Ser Glu Lys Lys Gln Pro Gln 
    370                 375                 380                 


Val Lys Glu Gly Asn Asn Thr Asn Lys Ser Glu Lys Ile Gln Leu Ser 
385                 390                 395                 400 


Glu Asn Ile Cys Asp Ser Thr Ser Ser Ala Ala Ala Gly Arg Leu Thr 
                405                 410                 415     


Gln Gln Arg Lys Ile Gly Lys Thr Tyr Pro Gln Gln Phe Pro Lys Lys 
            420                 425                 430         


Leu Lys Glu Glu His Asp Arg Cys Thr Leu Lys Gln Glu Asn Glu Glu 
        435                 440                 445             


Lys Thr Asn Val Asn Met Leu Tyr Lys Lys Asn Arg Glu Glu Leu Glu 
    450                 455                 460                 


Arg Lys Glu Lys Gln Tyr Lys Lys Glu Val Glu Ala Lys Gln Leu Glu 
465                 470                 475                 480 


Pro Thr Val Gln Ser Leu Glu Met Lys Ser Lys Thr Ala Arg Asn Thr 
                485                 490                 495     


Pro Asn Trp Asp Phe His Asn His Glu Glu Met Lys Gly Leu Met Asp 
            500                 505                 510         


Glu Asn Cys Ile Leu Lys Ala Asp Ile Ala Ile Leu Arg Gln Glu Ile 
        515                 520                 525             


Cys Thr Met Lys Asn Asp Asn Leu Glu Lys Glu Asn Lys Tyr Leu Lys 
    530                 535                 540                 


Asp Ile Lys Ile Val Lys Glu Thr Asn Ala Ala Leu Glu Lys Tyr Ile 
545                 550                 555                 560 


Lys Leu Asn Glu Glu Met Ile Thr Glu Thr Ala Phe Arg Tyr Gln Gln 
                565                 570                 575     


Glu Leu Asn Asp Leu Lys Ala Glu Asn Thr Arg Leu Asn Ala Glu Leu 
            580                 585                 590         


Leu Lys Glu Lys Glu Ser Lys Lys Arg Leu Glu Ala Asp Ile Glu Ser 
        595                 600                 605             


Tyr Gln Ser Arg Leu Ala Ala Ala Ile Ser Lys His Ser Glu Ser Val 
    610                 615                 620                 


Lys Thr Glu Arg Asn Leu Lys Leu Ala Leu Glu Arg Thr Gln Asp Val 
625                 630                 635                 640 


Ser Val Gln Val Glu Met Ser Ser Ala Ile Ser Lys Val Lys Asp Glu 
                645                 650                 655     


Asn Glu Phe Leu Thr Glu Gln Leu Ser Glu Thr Gln Ile Lys Phe Asn 
            660                 665                 670         


Ala Leu Lys Asp Lys Phe Arg Lys Thr Arg Asp Ser Leu Arg Lys Lys 
        675                 680                 685             


Ser Leu Ala Leu Glu Thr Val Gln Asn Asn Leu Ser Gln Thr Gln Gln 
    690                 695                 700                 


Gln Thr Gln Glu Met Lys Glu Met Tyr Gln Asn Ala Glu Ala Lys Val 
705                 710                 715                 720 


Asn Asn Ser Thr Gly Lys Trp Asn Cys Val Glu Glu Arg Ile Cys His 
                725                 730                 735     


Leu Gln Arg Glu Asn Ala Trp Leu Val Gln Gln Leu Asp Asp Val His 
            740                 745                 750         


Gln Lys Glu Asp His Lys Glu Ile Val Thr Asn Ile Gln Arg Gly Phe 
        755                 760                 765             


Ile Glu Ser Gly Lys Lys Asp Phe Val Leu Glu Glu Lys Ser Lys Lys 
    770                 775                 780                 


Leu Met Asn Glu Cys Asp His Leu Lys Glu Ser Leu Phe Gln Tyr Glu 
785                 790                 795                 800 


Arg Glu Lys Thr Glu Val Val Val Ser Ile Lys Glu Asp Lys Tyr Phe 
                805                 810                 815     


Gln Thr Ser Arg Lys Lys Ile 
            820             


<210>  6
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Arg Gln Leu Ala Gly Cys Gly Asp Ala Gly Lys Lys Ala Ser 
1               5                   10                  15      


Phe Lys Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu 
            20                  25                  30          


Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr 
        35                  40                  45              


Thr Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile 
    50                  55                  60                  


Lys Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn 
65                  70                  75                  80  


Arg Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg 
                85                  90                  95      


Thr Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His 
            100                 105                 110         


Leu Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp 
        115                 120                 125             


Ala Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp 
    130                 135                 140                 


Ser Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu 
145                 150                 155                 160 


Ile Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp 
                165                 170                 175     


Ile Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu 
            180                 185                 190         


Ala Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu 
        195                 200                 205             


Ile Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys 
    210                 215                 220                 


Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val 
225                 230                 235                 240 


Pro His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr 
                245                 250                 255     


Asp Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn 
            260                 265                 270         


Ala Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe 
        275                 280                 285             


Ala Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys 
    290                 295                 300                 


Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys 
305                 310                 315                 320 


Ile Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr 
                325                 330                 335     


Ile Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu 
            340                 345                 350         


Cys Gly Gly Asp Asp 
        355         


<210>  7
<211>  1101
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Ala Ala Pro Ala Tyr Ser Glu Asp Lys Gly Gly Ser Ala Gly 
1               5                   10                  15      


Pro Gly Glu Pro Glu Tyr Gly His Asp Pro Ala Ser Gly Gly Ile Phe 
            20                  25                  30          


Ser Ser Asp Tyr Lys Arg His Asp Asp Leu Lys Glu Met Leu Asp Thr 
        35                  40                  45              


Asn Lys Asp Ser Leu Lys Leu Glu Ala Met Lys Arg Ile Val Ala Met 
    50                  55                  60                  


Ile Ala Arg Gly Lys Asn Ala Ser Asp Leu Phe Pro Ala Val Val Lys 
65                  70                  75                  80  


Asn Val Ala Cys Lys Asn Ile Glu Val Lys Lys Leu Val Tyr Val Tyr 
                85                  90                  95      


Leu Val Arg Tyr Ala Glu Glu Gln Gln Asp Leu Ala Leu Leu Ser Ile 
            100                 105                 110         


Ser Thr Phe Gln Arg Gly Leu Lys Asp Pro Asn Gln Leu Ile Arg Ala 
        115                 120                 125             


Ser Ala Leu Arg Val Leu Ser Ser Ile Arg Val Pro Ile Ile Val Pro 
    130                 135                 140                 


Ile Met Met Leu Ala Ile Lys Glu Ala Ala Ser Asp Met Ser Pro Tyr 
145                 150                 155                 160 


Val Arg Lys Thr Ala Ala His Ala Ile Pro Lys Leu Tyr Ser Leu Asp 
                165                 170                 175     


Ser Asp Gln Lys Asp Gln Leu Ile Glu Val Ile Glu Lys Leu Leu Ala 
            180                 185                 190         


Asp Lys Thr Thr Leu Val Ala Gly Ser Val Val Met Ala Phe Glu Glu 
        195                 200                 205             


Val Cys Pro Glu Arg Ile Asp Leu Ile His Lys Asn Tyr Arg Lys Leu 
    210                 215                 220                 


Cys Asn Leu Leu Ile Asp Val Glu Glu Trp Gly Gln Val Val Ile Ile 
225                 230                 235                 240 


Ser Met Leu Thr Arg Tyr Ala Arg Thr Gln Phe Leu Ser Pro Thr Gln 
                245                 250                 255     


Asn Glu Ser Leu Leu Glu Glu Asn Ala Glu Lys Ala Phe Tyr Gly Ser 
            260                 265                 270         


Glu Glu Asp Glu Ala Lys Gly Ala Gly Ser Glu Glu Thr Ala Ala Ala 
        275                 280                 285             


Ala Ala Pro Ser Arg Lys Pro Tyr Val Met Asp Pro Asp His Arg Leu 
    290                 295                 300                 


Leu Leu Arg Asn Thr Lys Pro Leu Leu Gln Ser Arg Ser Ala Ala Val 
305                 310                 315                 320 


Val Met Ala Val Ala Gln Leu Tyr Phe His Leu Ala Pro Lys Ala Glu 
                325                 330                 335     


Val Gly Val Ile Ala Lys Ala Leu Val Arg Leu Leu Arg Ser His Ser 
            340                 345                 350         


Glu Val Gln Tyr Val Val Leu Gln Asn Val Ala Thr Met Ser Ile Lys 
        355                 360                 365             


Arg Arg Gly Met Phe Glu Pro Tyr Leu Lys Ser Phe Tyr Ile Arg Ser 
    370                 375                 380                 


Thr Asp Pro Thr Gln Ile Lys Ile Leu Lys Leu Glu Val Leu Thr Asn 
385                 390                 395                 400 


Leu Ala Asn Glu Thr Asn Ile Pro Thr Val Leu Arg Glu Phe Gln Thr 
                405                 410                 415     


Tyr Ile Arg Ser Met Asp Lys Asp Phe Val Ala Ala Thr Ile Gln Ala 
            420                 425                 430         


Ile Gly Arg Cys Ala Thr Asn Ile Gly Arg Val Arg Asp Thr Cys Leu 
        435                 440                 445             


Asn Gly Leu Val Gln Leu Leu Ser Asn Arg Asp Glu Leu Val Val Ala 
    450                 455                 460                 


Glu Ser Val Val Val Ile Lys Lys Leu Leu Gln Met Gln Pro Ala Gln 
465                 470                 475                 480 


His Gly Glu Ile Ile Lys His Leu Ala Lys Leu Thr Asp Asn Ile Gln 
                485                 490                 495     


Val Pro Met Ala Arg Ala Ser Ile Leu Trp Leu Ile Gly Glu Tyr Cys 
            500                 505                 510         


Glu His Val Pro Arg Ile Ala Pro Asp Val Leu Arg Lys Met Ala Lys 
        515                 520                 525             


Ser Phe Thr Ala Glu Glu Asp Ile Val Lys Leu Gln Val Ile Asn Leu 
    530                 535                 540                 


Ala Ala Lys Leu Tyr Leu Thr Asn Ser Lys Gln Thr Lys Leu Leu Thr 
545                 550                 555                 560 


Gln Tyr Val Leu Ser Leu Ala Lys Tyr Asp Gln Asn Tyr Asp Ile Arg 
                565                 570                 575     


Asp Arg Ala Arg Phe Thr Arg Gln Leu Ile Val Pro Ser Glu Gln Gly 
            580                 585                 590         


Gly Ala Leu Ser Arg His Ala Lys Lys Leu Phe Leu Ala Pro Lys Pro 
        595                 600                 605             


Ala Pro Val Leu Glu Ser Ser Phe Lys Asp Arg Asp His Phe Gln Leu 
    610                 615                 620                 


Gly Ser Leu Ser His Leu Leu Asn Ala Lys Ala Thr Gly Tyr Gln Glu 
625                 630                 635                 640 


Leu Pro Asp Trp Pro Glu Glu Ala Pro Asp Pro Ser Val Arg Asn Val 
                645                 650                 655     


Glu Glu Glu Asp Leu Ser Leu Ile Glu Thr His Val Gly Leu Leu Gly 
            660                 665                 670         


Glu Tyr Thr Glu Val Pro Glu Trp Thr Lys Cys Ser Asn Arg Glu Lys 
        675                 680                 685             


Arg Lys Glu Lys Glu Lys Pro Phe Tyr Ser Asp Ser Glu Gly Glu Ser 
    690                 695                 700                 


Gly Pro Thr Glu Ser Ala Asp Ser Asp Pro Glu Ser Glu Ser Glu Ser 
705                 710                 715                 720 


Asp Ser Lys Ser Ser Ser Glu Ser Gly Ser Gly Glu Ser Ser Ser Glu 
                725                 730                 735     


Ser Asp Asn Glu Asp Gln Asp Glu Asp Glu Glu Lys Gly Arg Gly Ser 
            740                 745                 750         


Glu Ser Glu Gln Ser Glu Glu Asp Gly Lys Arg Lys Thr Lys Lys Lys 
        755                 760                 765             


Val Pro Glu Arg Lys Gly Glu Ala Ser Ser Ser Asp Glu Gly Ser Asp 
    770                 775                 780                 


Ser Ser Ser Ser Ser Ser Glu Ser Glu Met Thr Ser Glu Ser Glu Glu 
785                 790                 795                 800 


Glu Gln Leu Glu Pro Ala Ser Trp Ser Arg Lys Thr Pro Pro Ser Ser 
                805                 810                 815     


Lys Ser Ala Pro Ala Thr Lys Glu Ile Ser Leu Leu Asp Leu Glu Asp 
            820                 825                 830         


Phe Thr Pro Pro Ser Val Gln Pro Val Ser Pro Pro Ala Ile Val Ser 
        835                 840                 845             


Thr Ser Leu Ala Ala Asp Leu Glu Gly Leu Thr Leu Thr Asp Ser Thr 
    850                 855                 860                 


Leu Val Pro Ser Leu Leu Ser Pro Val Ser Gly Val Gly Arg Gln Glu 
865                 870                 875                 880 


Leu Leu His Arg Val Ala Gly Glu Gly Leu Ala Val Asp Tyr Thr Phe 
                885                 890                 895     


Ser Arg Gln Pro Phe Ser Gly Asp Pro His Met Val Ser Val His Ile 
            900                 905                 910         


His Phe Ser Asn Ser Ser Asp Thr Pro Ile Lys Gly Leu His Val Gly 
        915                 920                 925             


Thr Pro Lys Leu Pro Ala Gly Ile Ser Ile Gln Glu Phe Pro Glu Ile 
    930                 935                 940                 


Glu Ser Leu Ala Pro Gly Glu Ser Ala Thr Ala Val Met Gly Ile Asn 
945                 950                 955                 960 


Phe Cys Asp Ser Thr Gln Ala Ala Asn Phe Gln Leu Cys Thr Gln Thr 
                965                 970                 975     


Arg Gln Phe Tyr Val Ser Ile Gln Pro Pro Val Gly Glu Leu Met Ala 
            980                 985                 990         


Pro Val Phe Met Ser Glu Asn Glu  Phe Lys Lys Glu Gln  Gly Lys Leu 
        995                 1000                 1005             


Met Gly  Met Asn Glu Ile Thr  Glu Lys Leu Met Leu  Pro Asp Thr 
    1010                 1015                 1020             


Cys Arg  Ser Asp His Ile Val  Val Gln Lys Val Thr  Ala Thr Ala 
    1025                 1030                 1035             


Asn Leu  Gly Arg Val Pro Cys  Gly Thr Ser Asp Glu  Tyr Arg Phe 
    1040                 1045                 1050             


Ala Gly  Arg Thr Leu Thr Gly  Gly Ser Leu Val Leu  Leu Thr Leu 
    1055                 1060                 1065             


Asp Ala  Arg Pro Ala Gly Ala  Ala Gln Leu Thr Val  Asn Ser Glu 
    1070                 1075                 1080             


Lys Met  Val Ile Gly Thr Met  Leu Val Lys Asp Val  Ile Gln Ala 
    1085                 1090                 1095             


Leu Thr  Gln 
    1100     


<210>  8
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  9
<211>  4563
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  10
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Ser Gly Ala Ser Arg Lys Ser Trp Asp Pro Gly Asn Pro Trp 
1               5                   10                  15      


Pro Pro Asp Trp Pro Ile Thr Gly Arg Lys Met Lys Val Leu Trp Ala 
            20                  25                  30          


Ala Leu Leu Val Thr Phe Leu Ala Gly Cys Gln Ala Lys Val Glu Gln 
        35                  40                  45              


Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln Gln Thr Glu Trp 
    50                  55                  60                  


Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Trp Asp Tyr 
65                  70                  75                  80  


Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu 
                85                  90                  95      


Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met 
            100                 105                 110         


Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro 
        115                 120                 125             


Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala 
    130                 135                 140                 


Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Cys Gly Arg Leu Val 
145                 150                 155                 160 


Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu 
                165                 170                 175     


Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
            180                 185                 190         


Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala 
        195                 200                 205             


Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala Ile Arg Glu Arg 
    210                 215                 220                 


Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala Ala Thr Val Gly 
225                 230                 235                 240 


Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln Ala Trp Gly Glu 
                245                 250                 255     


Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg Thr Arg Asp Arg 
            260                 265                 270         


Leu Asp Glu Val Lys Glu Gln Val Ala Glu Val Arg Ala Lys Leu Glu 
        275                 280                 285             


Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala Phe Gln Ala Arg 
    290                 295                 300                 


Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met Gln Arg Gln Trp 
305                 310                 315                 320 


Ala Gly Leu Val Glu Lys Val Gln Ala Ala Val Gly Thr Ser Ala Ala 
                325                 330                 335     


Pro Val Pro Ser Asp Asn His 
            340             


<210>  11
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr 
            100                 105                 110         


Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu 
        115                 120                 125             


Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu 
    130                 135                 140                 


Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly 
145                 150                 155                 160 


Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr 
                165                 170                 175     


Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu 
            180                 185                 190         


Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val 
        195                 200                 205             


Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu 
    210                 215                 220                 


Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys 
225                 230                 235         


<210>  12
<211>  1288
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ala Ala Gly Ala Arg Leu Ser Pro Gly Pro Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Arg Pro Arg Leu Cys Phe His Pro Gly Pro Pro Pro Leu Leu 
            20                  25                  30          


Pro Leu Leu Leu Leu Phe Leu Leu Leu Leu Pro Pro Pro Pro Leu Leu 
        35                  40                  45              


Ala Gly Ala Thr Ala Ala Ala Ser Arg Glu Pro Asp Ser Pro Cys Arg 
    50                  55                  60                  


Leu Lys Thr Val Thr Val Ser Thr Leu Pro Ala Leu Arg Glu Ser Asp 
65                  70                  75                  80  


Ile Gly Trp Ser Gly Ala Arg Ala Gly Ala Gly Ala Gly Thr Gly Ala 
                85                  90                  95      


Gly Ala Ala Ala Ala Ala Ala Ser Pro Gly Ser Pro Gly Ser Ala Gly 
            100                 105                 110         


Thr Ala Ala Glu Ser Arg Leu Leu Leu Phe Val Arg Asn Glu Leu Pro 
        115                 120                 125             


Gly Arg Ile Ala Val Gln Asp Asp Leu Asp Asn Thr Glu Leu Pro Phe 
    130                 135                 140                 


Phe Thr Leu Glu Met Ser Gly Thr Ala Ala Asp Ile Ser Leu Val His 
145                 150                 155                 160 


Trp Arg Gln Gln Trp Leu Glu Asn Gly Thr Leu Tyr Phe His Val Ser 
                165                 170                 175     


Met Ser Ser Ser Gly Gln Leu Ala Gln Ala Thr Ala Pro Thr Leu Gln 
            180                 185                 190         


Glu Pro Ser Glu Ile Val Glu Glu Gln Met His Ile Leu His Ile Ser 
        195                 200                 205             


Val Met Gly Gly Leu Ile Ala Leu Leu Leu Leu Leu Leu Val Phe Thr 
    210                 215                 220                 


Val Ala Leu Tyr Ala Gln Arg Arg Trp Gln Lys Arg Arg Arg Ile Pro 
225                 230                 235                 240 


Gln Lys Ser Ala Ser Thr Glu Ala Thr His Glu Ile His Tyr Ile Pro 
                245                 250                 255     


Ser Val Leu Leu Gly Pro Gln Ala Arg Glu Ser Phe Arg Ser Ser Arg 
            260                 265                 270         


Leu Gln Thr His Asn Ser Val Ile Gly Val Pro Ile Arg Glu Thr Pro 
        275                 280                 285             


Ile Leu Asp Asp Tyr Asp Cys Glu Glu Asp Glu Glu Pro Pro Arg Arg 
    290                 295                 300                 


Ala Asn His Val Ser Arg Glu Asp Glu Phe Gly Ser Gln Val Thr His 
305                 310                 315                 320 


Thr Leu Asp Ser Leu Gly His Pro Gly Glu Glu Lys Val Asp Phe Glu 
                325                 330                 335     


Lys Lys Gly Gly Ile Ser Phe Gly Arg Ala Lys Gly Thr Ser Gly Ser 
            340                 345                 350         


Glu Ala Asp Asp Glu Thr Gln Leu Thr Phe Tyr Thr Glu Gln Tyr Arg 
        355                 360                 365             


Ser Arg Arg Arg Ser Lys Gly Leu Leu Lys Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Ala Leu Thr Leu Ile Ala Val Ser Ser Cys Ile Leu Ala Met Val Cys 
385                 390                 395                 400 


Gly Ser Gln Met Ser Cys Pro Leu Thr Val Lys Val Thr Leu His Val 
                405                 410                 415     


Pro Glu His Phe Ile Ala Asp Gly Ser Ser Phe Val Val Ser Glu Gly 
            420                 425                 430         


Ser Tyr Leu Asp Ile Ser Asp Trp Leu Asn Pro Ala Lys Leu Ser Leu 
        435                 440                 445             


Tyr Tyr Gln Ile Asn Ala Thr Ser Pro Trp Val Arg Asp Leu Cys Gly 
    450                 455                 460                 


Gln Arg Thr Thr Asp Ala Cys Glu Gln Leu Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Ser Cys His Glu Gly Tyr Ala Pro Asp Pro Val His Arg His 
                485                 490                 495     


Leu Cys Val Arg Ser Asp Trp Gly Gln Ser Glu Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Thr Leu Glu Arg Gly Tyr Asp Leu Val Thr Gly Glu Gln Ala Pro 
        515                 520                 525             


Glu Lys Ile Leu Arg Ser Thr Phe Ser Leu Gly Gln Gly Leu Trp Leu 
    530                 535                 540                 


Pro Val Ser Lys Ser Phe Val Val Pro Pro Val Glu Leu Ser Ile Asn 
545                 550                 555                 560 


Pro Leu Ala Ser Cys Lys Thr Asp Val Leu Val Thr Glu Asp Pro Ala 
                565                 570                 575     


Asp Val Arg Glu Glu Ala Met Leu Ser Thr Tyr Phe Glu Thr Ile Asn 
            580                 585                 590         


Asp Leu Leu Ser Ser Phe Gly Pro Val Arg Asp Cys Ser Arg Asn Asn 
        595                 600                 605             


Gly Gly Cys Thr Arg Asn Phe Lys Cys Val Ser Asp Arg Gln Val Asp 
    610                 615                 620                 


Ser Ser Gly Cys Val Cys Pro Glu Glu Leu Lys Pro Met Lys Asp Gly 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp His Ser Lys Gly Ile Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Thr Leu Pro Leu Pro 
            660                 665                 670         


Tyr Asp Ala Thr Ser Ser Thr Ile Phe Met Phe Cys Gly Cys Val Glu 
        675                 680                 685             


Glu Tyr Lys Leu Ala Pro Asp Gly Lys Ser Cys Leu Met Leu Ser Asp 
    690                 695                 700                 


Val Cys Glu Gly Pro Lys Cys Leu Lys Pro Asp Ser Lys Phe Asn Asp 
705                 710                 715                 720 


Thr Leu Phe Gly Glu Met Leu His Gly Tyr Asn Asn Arg Thr Gln His 
                725                 730                 735     


Val Asn Gln Gly Gln Val Phe Gln Met Thr Phe Arg Glu Asn Asn Phe 
            740                 745                 750         


Ile Lys Asp Phe Pro Gln Leu Ala Asp Gly Leu Leu Val Ile Pro Leu 
        755                 760                 765             


Pro Val Glu Glu Gln Cys Arg Gly Val Leu Ser Glu Pro Leu Pro Asp 
    770                 775                 780                 


Leu Gln Leu Leu Thr Gly Asp Ile Arg Tyr Asp Glu Ala Met Gly Tyr 
785                 790                 795                 800 


Pro Met Val Gln Gln Trp Arg Val Arg Ser Asn Leu Tyr Arg Val Lys 
                805                 810                 815     


Leu Ser Thr Ile Thr Leu Ala Ala Gly Phe Thr Asn Val Leu Lys Ile 
            820                 825                 830         


Leu Thr Lys Glu Ser Ser Arg Glu Glu Leu Leu Ser Phe Ile Gln His 
        835                 840                 845             


Tyr Gly Ser His Tyr Ile Ala Glu Ala Leu Tyr Gly Ser Glu Leu Thr 
    850                 855                 860                 


Cys Ile Ile His Phe Pro Ser Lys Lys Val Gln Gln Gln Leu Trp Leu 
865                 870                 875                 880 


Gln Tyr Gln Lys Glu Thr Thr Glu Leu Gly Ser Lys Lys Glu Leu Lys 
                885                 890                 895     


Ser Met Pro Phe Ile Thr Tyr Leu Ser Gly Leu Leu Thr Ala Gln Met 
            900                 905                 910         


Leu Ser Asp Asp Gln Leu Ile Ser Gly Val Glu Ile Arg Cys Glu Glu 
        915                 920                 925             


Lys Gly Arg Cys Pro Ser Thr Cys His Leu Cys Arg Arg Pro Gly Lys 
    930                 935                 940                 


Glu Gln Leu Ser Pro Thr Pro Val Leu Leu Glu Ile Asn Arg Val Val 
945                 950                 955                 960 


Pro Leu Tyr Thr Leu Ile Gln Asp Asn Gly Thr Lys Glu Ala Phe Lys 
                965                 970                 975     


Ser Ala Leu Met Ser Ser Tyr Trp Cys Ser Gly Lys Gly Asp Val Ile 
            980                 985                 990         


Asp Asp Trp Cys Arg Cys Asp Leu  Ser Ala Phe Asp Ala  Asn Gly Leu 
        995                 1000                 1005             


Pro Asn  Cys Ser Pro Leu Leu  Gln Pro Val Leu Arg  Leu Ser Pro 
    1010                 1015                 1020             


Thr Val  Glu Pro Ser Ser Thr  Val Val Ser Leu Glu  Trp Val Asp 
    1025                 1030                 1035             


Val Gln  Pro Ala Ile Gly Thr  Lys Val Ser Asp Tyr  Ile Leu Gln 
    1040                 1045                 1050             


His Lys  Lys Val Asp Glu Tyr  Thr Asp Thr Asp Leu  Tyr Thr Gly 
    1055                 1060                 1065             


Glu Phe  Leu Ser Phe Ala Asp  Asp Leu Leu Ser Gly  Leu Gly Thr 
    1070                 1075                 1080             


Ser Cys  Val Ala Ala Gly Arg  Ser His Gly Glu Val  Pro Glu Val 
    1085                 1090                 1095             


Ser Ile  Tyr Ser Val Ile Phe  Lys Cys Leu Glu Pro  Asp Gly Leu 
    1100                 1105                 1110             


Tyr Lys  Phe Thr Leu Tyr Ala  Val Asp Thr Arg Gly  Arg His Ser 
    1115                 1120                 1125             


Glu Leu  Ser Thr Val Thr Leu  Arg Thr Ala Cys Pro  Leu Val Asp 
    1130                 1135                 1140             


Asp Asn  Lys Ala Glu Glu Ile  Ala Asp Lys Ile Tyr  Asn Leu Tyr 
    1145                 1150                 1155             


Asn Gly  Tyr Thr Ser Gly Lys  Glu Gln Gln Met Ala  Tyr Asn Thr 
    1160                 1165                 1170             


Leu Met  Glu Val Ser Ala Ser  Met Leu Phe Arg Val  Gln His His 
    1175                 1180                 1185             


Tyr Asn  Ser His Tyr Glu Lys  Phe Gly Asp Phe Val  Trp Arg Ser 
    1190                 1195                 1200             


Glu Asp  Glu Leu Gly Pro Arg  Lys Ala His Leu Ile  Leu Arg Arg 
    1205                 1210                 1215             


Leu Glu  Arg Val Ser Ser His  Cys Ser Ser Leu Leu  Arg Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Gln Ser Arg Val Glu  Thr Val Pro Tyr Leu  Phe Cys Arg 
    1235                 1240                 1245             


Ser Glu  Glu Val Arg Pro Ala  Gly Met Val Trp Tyr  Ser Ile Leu 
    1250                 1255                 1260             


Lys Asp  Thr Lys Ile Thr Cys  Glu Glu Lys Met Val  Ser Met Ala 
    1265                 1270                 1275             


Arg Asn  Thr Tyr Gly Glu Ser  Lys Gly Arg 
    1280                 1285             


<210>  13
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Ser Lys Met Asn Leu Ile Glu His Ser His Leu Pro Thr Thr 
1               5                   10                  15      


Asp Glu Phe Ser Phe Ser Glu Asn Leu Phe Gly Val Leu Thr Glu Gln 
            20                  25                  30          


Val Ala Gly Pro Leu Gly Gln Asn Leu Glu Val Glu Pro Tyr Ser Gln 
        35                  40                  45              


Tyr Ser Asn Val Gln Phe Pro Gln Val Gln Pro Gln Ile Ser Ser Ser 
    50                  55                  60                  


Ser Tyr Tyr Ser Asn Leu Gly Phe Tyr Pro Gln Gln Pro Glu Glu Trp 
65                  70                  75                  80  


Tyr Ser Pro Gly Ile Tyr Glu Leu Arg Arg Met Pro Ala Glu Thr Leu 
                85                  90                  95      


Tyr Gln Gly Glu Thr Glu Val Ala Glu Met Pro Val Thr Lys Lys Pro 
            100                 105                 110         


Arg Met Gly Ala Ser Ala Gly Arg Ile Lys Gly Asp Glu Leu Cys Val 
        115                 120                 125             


Val Cys Gly Asp Arg Ala Ser Gly Tyr His Tyr Asn Ala Leu Thr Cys 
    130                 135                 140                 


Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Thr Lys Asn Ala Val 
145                 150                 155                 160 


Tyr Lys Cys Lys Asn Gly Gly Asn Cys Val Met Asp Met Tyr Met Arg 
                165                 170                 175     


Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Lys Glu Met Gly Met 
            180                 185                 190         


Leu Ala Glu Cys Met Tyr Thr Gly Leu Leu Thr Glu Ile Gln Cys Lys 
        195                 200                 205             


Ser Lys Arg Leu Arg Lys Asn Val Lys Gln His Ala Asp Gln Thr Val 
    210                 215                 220                 


Asn Glu Asp Ser Glu Gly Arg Asp Leu Arg Gln Val Thr Ser Thr Thr 
225                 230                 235                 240 


Lys Ser Cys Arg Glu Lys Thr Glu Leu Thr Pro Asp Gln Gln Thr Leu 
                245                 250                 255     


Leu His Phe Ile Met Asp Ser Tyr Asn Lys Gln Arg Met Pro Gln Glu 
            260                 265                 270         


Ile Thr Asn Lys Ile Leu Lys Glu Glu Phe Ser Ala Glu Glu Asn Phe 
        275                 280                 285             


Leu Ile Leu Thr Glu Met Ala Thr Asn His Val Gln Val Leu Val Glu 
    290                 295                 300                 


Phe Thr Lys Lys Leu Pro Gly Phe Gln Thr Leu Asp His Glu Asp Gln 
305                 310                 315                 320 


Ile Ala Leu Leu Lys Gly Ser Ala Val Glu Ala Met Phe Leu Arg Ser 
                325                 330                 335     


Ala Glu Ile Phe Asn Lys Lys Leu Pro Ser Gly His Ser Asp Leu Leu 
            340                 345                 350         


Glu Glu Arg Ile Arg Asn Ser Gly Ile Ser Asp Glu Tyr Ile Thr Pro 
        355                 360                 365             


Met Phe Ser Phe Tyr Lys Ser Ile Gly Glu Leu Lys Met Thr Gln Glu 
    370                 375                 380                 


Glu Tyr Ala Leu Leu Thr Ala Ile Val Ile Leu Ser Pro Asp Arg Gln 
385                 390                 395                 400 


Tyr Ile Lys Asp Arg Glu Ala Val Glu Lys Leu Gln Glu Pro Leu Leu 
                405                 410                 415     


Asp Val Leu Gln Lys Leu Cys Lys Ile His Gln Pro Glu Asn Pro Gln 
            420                 425                 430         


His Phe Ala Cys Leu Leu Gly Arg Leu Thr Glu Leu Arg Thr Phe Asn 
        435                 440                 445             


His His His Ala Glu Met Leu Met Ser Trp Arg Val Asn Asp His Lys 
    450                 455                 460                 


Phe Thr Pro Leu Leu Cys Glu Ile Trp Asp Val Gln 
465                 470                 475     


<210>  14
<211>  3051
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Thr Asn Pro Gln Pro Gln Pro Pro Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Gln Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Gly Pro 
            20                  25                  30          


Gly Ala Gly Pro Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala 
        35                  40                  45              


Gly Asp Pro Gln Leu Val Ala Met Ile Val Asn His Leu Lys Ser Gln 
    50                  55                  60                  


Gly Leu Phe Asp Gln Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr 
65                  70                  75                  80  


Lys Pro Ala Tyr Gln Asn Leu Arg Gln Arg Val Asp Asn Phe Val Ala 
                85                  90                  95      


Asn His Leu Ala Thr His Thr Trp Ser Pro His Leu Asn Lys Asn Gln 
            100                 105                 110         


Leu Arg Asn Asn Ile Arg Gln Gln Val Leu Lys Ser Gly Met Leu Glu 
        115                 120                 125             


Ser Gly Ile Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Ile Asn 
    130                 135                 140                 


His Thr Phe Arg Pro Gln Val Glu Lys Ala Val His Glu Phe Leu Ala 
145                 150                 155                 160 


Thr Leu Asn His Lys Glu Glu Gly Ser Gly Asn Thr Ala Pro Asp Asp 
                165                 170                 175     


Glu Lys Pro Asp Thr Ser Leu Ile Thr Gln Gly Val Pro Thr Pro Gly 
            180                 185                 190         


Pro Ser Ala Asn Val Ala Asn Asp Ala Met Ser Ile Leu Glu Thr Ile 
        195                 200                 205             


Thr Ser Leu Asn Gln Glu Ala Ser Ala Ala Arg Ala Ser Thr Glu Thr 
    210                 215                 220                 


Ser Asn Ala Lys Thr Ser Glu Arg Ala Ser Lys Lys Leu Pro Ser Gln 
225                 230                 235                 240 


Pro Thr Thr Asp Thr Ser Thr Asp Lys Glu Arg Thr Ser Glu Asp Met 
                245                 250                 255     


Ala Asp Lys Glu Lys Ser Thr Ala Asp Ser Gly Gly Glu Gly Leu Glu 
            260                 265                 270         


Thr Ala Pro Lys Ser Glu Glu Phe Ser Asp Leu Pro Cys Pro Val Glu 
        275                 280                 285             


Glu Ile Lys Asn Tyr Thr Lys Glu His Asn Asn Leu Ile Leu Leu Asn 
    290                 295                 300                 


Lys Asp Val Gln Gln Glu Ser Ser Glu Gln Lys Asn Lys Ser Thr Asp 
305                 310                 315                 320 


Lys Gly Glu Lys Lys Pro Asp Ser Asn Glu Lys Gly Glu Arg Lys Lys 
                325                 330                 335     


Glu Lys Lys Glu Lys Thr Glu Lys Lys Phe Asp His Ser Lys Lys Ser 
            340                 345                 350         


Glu Asp Thr Gln Lys Val Lys Asp Glu Lys Gln Ala Lys Glu Lys Glu 
        355                 360                 365             


Val Glu Ser Leu Lys Leu Pro Ser Glu Lys Asn Ser Asn Lys Ala Lys 
    370                 375                 380                 


Thr Val Glu Gly Thr Lys Glu Asp Phe Ser Leu Ile Asp Ser Asp Val 
385                 390                 395                 400 


Asp Gly Leu Thr Asp Ile Thr Val Ser Ser Val His Thr Ser Asp Leu 
                405                 410                 415     


Ser Ser Phe Glu Glu Asp Thr Glu Glu Glu Val Val Thr Ser Asp Ser 
            420                 425                 430         


Met Glu Glu Gly Glu Ile Thr Ser Asp Asp Glu Glu Lys Asn Lys Gln 
        435                 440                 445             


Asn Lys Thr Lys Thr Gln Thr Ser Asp Ser Ser Glu Gly Lys Thr Lys 
    450                 455                 460                 


Ser Val Arg His Ala Tyr Val His Lys Pro Tyr Leu Tyr Ser Lys Tyr 
465                 470                 475                 480 


Tyr Ser Asp Ser Asp Asp Glu Leu Thr Val Glu Gln Arg Arg Gln Ser 
                485                 490                 495     


Ile Ala Lys Glu Lys Glu Glu Arg Leu Leu Arg Arg Gln Ile Asn Arg 
            500                 505                 510         


Glu Lys Leu Glu Glu Lys Arg Lys Gln Lys Ala Glu Lys Thr Lys Ser 
        515                 520                 525             


Ser Lys Thr Lys Gly Gln Gly Arg Ser Ser Val Asp Leu Glu Glu Ser 
    530                 535                 540                 


Ser Thr Lys Ser Leu Glu Pro Lys Ala Ala Arg Ile Lys Glu Val Leu 
545                 550                 555                 560 


Lys Glu Arg Lys Val Leu Glu Lys Lys Val Ala Leu Ser Lys Lys Arg 
                565                 570                 575     


Lys Lys Asp Ser Arg Asn Val Glu Glu Asn Ser Lys Lys Lys Gln Gln 
            580                 585                 590         


Tyr Glu Glu Asp Ser Lys Glu Thr Leu Lys Thr Ser Glu His Cys Glu 
        595                 600                 605             


Lys Glu Lys Ile Ser Ser Ser Lys Glu Leu Lys His Val His Ala Lys 
    610                 615                 620                 


Ser Glu Pro Ser Lys Pro Ala Arg Arg Leu Ser Glu Ser Leu His Val 
625                 630                 635                 640 


Val Asp Glu Asn Lys Asn Glu Ser Lys Leu Glu Arg Glu His Lys Arg 
                645                 650                 655     


Arg Thr Ser Thr Pro Val Ile Met Glu Gly Val Gln Glu Glu Thr Asp 
            660                 665                 670         


Thr Arg Asp Val Lys Arg Gln Val Glu Arg Ser Glu Ile Cys Thr Glu 
        675                 680                 685             


Glu Pro Gln Lys Gln Lys Ser Thr Leu Lys Asn Glu Lys His Leu Lys 
    690                 695                 700                 


Lys Asp Asp Ser Glu Thr Pro His Leu Lys Ser Leu Leu Lys Lys Glu 
705                 710                 715                 720 


Val Lys Ser Ser Lys Glu Lys Pro Glu Arg Glu Lys Thr Pro Ser Glu 
                725                 730                 735     


Asp Lys Leu Ser Val Lys His Lys Tyr Lys Gly Asp Cys Met His Lys 
            740                 745                 750         


Thr Gly Asp Glu Thr Glu Leu His Ser Ser Glu Lys Gly Leu Lys Val 
        755                 760                 765             


Glu Glu Asn Ile Gln Lys Gln Ser Gln Gln Thr Lys Leu Ser Ser Asp 
    770                 775                 780                 


Asp Lys Thr Glu Arg Lys Ser Lys His Arg Asn Glu Arg Lys Leu Ser 
785                 790                 795                 800 


Val Leu Gly Lys Asp Gly Lys Pro Val Ser Glu Tyr Ile Ile Lys Thr 
                805                 810                 815     


Asp Glu Asn Val Arg Lys Glu Asn Asn Lys Lys Glu Arg Arg Leu Ser 
            820                 825                 830         


Ala Glu Lys Thr Lys Ala Glu His Lys Ser Arg Arg Ser Ser Asp Ser 
        835                 840                 845             


Lys Ile Gln Lys Asp Ser Leu Gly Ser Lys Gln His Gly Ile Thr Leu 
    850                 855                 860                 


Gln Arg Arg Ser Glu Ser Tyr Ser Glu Asp Lys Cys Asp Met Asp Ser 
865                 870                 875                 880 


Thr Asn Met Asp Ser Asn Leu Lys Pro Glu Glu Val Val His Lys Glu 
                885                 890                 895     


Lys Arg Arg Thr Lys Ser Leu Leu Glu Glu Lys Leu Val Leu Lys Ser 
            900                 905                 910         


Lys Ser Lys Thr Gln Gly Lys Gln Val Lys Val Val Glu Thr Glu Leu 
        915                 920                 925             


Gln Glu Gly Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro Asp Lys Glu 
    930                 935                 940                 


Lys Asn Thr Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys Ser Lys Val 
945                 950                 955                 960 


Glu Asp Lys Pro Phe Glu Glu Thr Gly Val Glu Pro Val Leu Glu Thr 
                965                 970                 975     


Ala Ser Ser Ser Ala His Ser Thr Gln Lys Asp Ser Ser His Arg Ala 
            980                 985                 990         


Lys Leu Pro Leu Ala Lys Glu Lys  Tyr Lys Ser Asp Lys  Asp Ser Thr 
        995                 1000                 1005             


Ser Thr  Arg Leu Glu Arg Lys  Leu Ser Asp Gly His  Lys Ser Arg 
    1010                 1015                 1020             


Ser Leu  Lys His Ser Ser Lys  Asp Ile Lys Lys Lys  Asp Glu Asn 
    1025                 1030                 1035             


Lys Ser  Asp Asp Lys Asp Gly  Lys Glu Val Asp Ser  Ser His Glu 
    1040                 1045                 1050             


Lys Ala  Arg Gly Asn Ser Ser  Leu Met Glu Lys Lys  Leu Ser Arg 
    1055                 1060                 1065             


Arg Leu  Cys Glu Asn Arg Arg  Gly Ser Leu Ser Gln  Glu Met Ala 
    1070                 1075                 1080             


Lys Gly  Glu Glu Lys Leu Ala  Ala Asn Thr Leu Ser  Thr Pro Ser 
    1085                 1090                 1095             


Gly Ser  Ser Leu Gln Arg Pro  Lys Lys Ser Gly Asp  Met Thr Leu 
    1100                 1105                 1110             


Ile Pro  Glu Gln Glu Pro Met  Glu Ile Asp Ser Glu  Pro Gly Val 
    1115                 1120                 1125             


Glu Asn  Val Phe Glu Val Ser  Lys Thr Gln Asp Asn  Arg Asn Asn 
    1130                 1135                 1140             


Asn Ser  Gln Gln Asp Ile Asp  Ser Glu Asn Met Lys  Gln Lys Thr 
    1145                 1150                 1155             


Ser Ala  Thr Val Gln Lys Asp  Glu Leu Arg Thr Cys  Thr Ala Asp 
    1160                 1165                 1170             


Ser Lys  Ala Thr Ala Pro Ala  Tyr Lys Pro Gly Arg  Gly Thr Gly 
    1175                 1180                 1185             


Val Asn  Ser Asn Ser Glu Lys  His Ala Asp His Arg  Ser Thr Leu 
    1190                 1195                 1200             


Thr Lys  Lys Met His Ile Gln  Ser Ala Val Ser Lys  Met Asn Pro 
    1205                 1210                 1215             


Gly Glu  Lys Glu Pro Ile His  Arg Gly Thr Thr Glu  Val Asn Ile 
    1220                 1225                 1230             


Asp Ser  Glu Thr Val His Arg  Met Leu Leu Ser Ala  Pro Ser Glu 
    1235                 1240                 1245             


Asn Asp  Arg Val Gln Lys Asn  Leu Lys Asn Thr Ala  Ala Glu Glu 
    1250                 1255                 1260             


His Val  Ala Gln Gly Asp Ala  Thr Leu Glu His Ser  Thr Asn Leu 
    1265                 1270                 1275             


Asp Ser  Ser Pro Ser Leu Ser  Ser Val Thr Val Val  Pro Leu Arg 
    1280                 1285                 1290             


Glu Ser  Tyr Asp Pro Asp Val  Ile Pro Leu Phe Asp  Lys Arg Thr 
    1295                 1300                 1305             


Val Leu  Glu Gly Ser Thr Ala  Ser Thr Ser Pro Ala  Asp His Ser 
    1310                 1315                 1320             


Ala Leu  Pro Asn Gln Ser Leu  Thr Val Arg Glu Ser  Glu Val Leu 
    1325                 1330                 1335             


Lys Thr  Ser Asp Ser Lys Glu  Gly Gly Glu Gly Phe  Thr Val Asp 
    1340                 1345                 1350             


Thr Pro  Ala Lys Ala Ser Ile  Thr Ser Lys Arg His  Ile Pro Glu 
    1355                 1360                 1365             


Ala His  Gln Ala Thr Leu Leu  Asp Gly Lys Gln Gly  Lys Val Ile 
    1370                 1375                 1380             


Met Pro  Leu Gly Ser Lys Leu  Thr Gly Val Ile Val  Glu Asn Glu 
    1385                 1390                 1395             


Asn Ile  Thr Lys Glu Gly Gly  Leu Val Asp Met Ala  Lys Lys Glu 
    1400                 1405                 1410             


Asn Asp  Leu Asn Ala Glu Pro  Asn Leu Lys Gln Thr  Ile Lys Ala 
    1415                 1420                 1425             


Thr Val  Glu Asn Gly Lys Lys  Asp Gly Ile Ala Val  Asp His Val 
    1430                 1435                 1440             


Val Gly  Leu Asn Thr Glu Lys  Tyr Ala Glu Thr Val  Lys Leu Lys 
    1445                 1450                 1455             


His Lys  Arg Ser Pro Gly Lys  Val Lys Asp Ile Ser  Ile Asp Val 
    1460                 1465                 1470             


Glu Arg  Arg Asn Glu Asn Ser  Glu Val Asp Thr Ser  Ala Gly Ser 
    1475                 1480                 1485             


Gly Ser  Ala Pro Ser Val Leu  His Gln Arg Asn Gly  Gln Thr Glu 
    1490                 1495                 1500             


Asp Val  Ala Thr Gly Pro Arg  Arg Ala Glu Lys Thr  Ser Val Ala 
    1505                 1510                 1515             


Thr Ser  Thr Glu Gly Lys Asp  Lys Asp Val Thr Leu  Ser Pro Val 
    1520                 1525                 1530             


Lys Ala  Gly Pro Ala Thr Thr  Thr Ser Ser Glu Thr  Arg Gln Ser 
    1535                 1540                 1545             


Glu Val  Ala Leu Pro Cys Thr  Ser Ile Glu Ala Asp  Glu Gly Leu 
    1550                 1555                 1560             


Ile Ile  Gly Thr His Ser Arg  Asn Asn Pro Leu His  Val Gly Ala 
    1565                 1570                 1575             


Glu Ala  Ser Glu Cys Thr Val  Phe Ala Ala Ala Glu  Glu Gly Gly 
    1580                 1585                 1590             


Ala Val  Val Thr Glu Gly Phe  Ala Glu Ser Glu Thr  Phe Leu Thr 
    1595                 1600                 1605             


Ser Thr  Lys Glu Gly Glu Ser  Gly Glu Cys Ala Val  Ala Glu Ser 
    1610                 1615                 1620             


Glu Asp  Arg Ala Ala Asp Leu  Leu Ala Val His Ala  Val Lys Ile 
    1625                 1630                 1635             


Glu Ala  Asn Val Asn Ser Val  Val Thr Glu Glu Lys  Asp Asp Ala 
    1640                 1645                 1650             


Val Thr  Ser Ala Gly Ser Glu  Glu Lys Cys Asp Gly  Ser Leu Ser 
    1655                 1660                 1665             


Arg Asp  Ser Glu Ile Val Glu  Gly Thr Ile Thr Phe  Ile Ser Glu 
    1670                 1675                 1680             


Val Glu  Ser Asp Gly Ala Val  Thr Ser Ala Gly Thr  Glu Ile Arg 
    1685                 1690                 1695             


Ala Gly  Ser Ile Ser Ser Glu  Glu Val Asp Gly Ser  Gln Gly Asn 
    1700                 1705                 1710             


Met Met  Arg Met Gly Pro Lys  Lys Glu Thr Glu Gly  Thr Val Thr 
    1715                 1720                 1725             


Cys Thr  Gly Ala Glu Gly Arg  Ser Asp Asn Phe Val  Ile Cys Ser 
    1730                 1735                 1740             


Val Thr  Gly Ala Gly Pro Arg  Glu Glu Arg Met Val  Thr Gly Ala 
    1745                 1750                 1755             


Gly Val  Val Leu Gly Asp Asn  Asp Ala Pro Pro Gly  Thr Ser Ala 
    1760                 1765                 1770             


Ser Gln  Glu Gly Asp Gly Ser  Val Asn Asp Gly Thr  Glu Gly Glu 
    1775                 1780                 1785             


Ser Ala  Val Thr Ser Thr Gly  Ile Thr Glu Asp Gly  Glu Gly Pro 
    1790                 1795                 1800             


Ala Ser  Cys Thr Gly Ser Glu  Asp Ser Ser Glu Gly  Phe Ala Ile 
    1805                 1810                 1815             


Ser Ser  Glu Ser Glu Glu Asn  Gly Glu Ser Ala Met  Asp Ser Thr 
    1820                 1825                 1830             


Val Ala  Lys Glu Gly Thr Asn  Val Pro Leu Val Ala  Ala Gly Pro 
    1835                 1840                 1845             


Cys Asp  Asp Glu Gly Ile Val  Thr Ser Thr Gly Ala  Lys Glu Glu 
    1850                 1855                 1860             


Asp Glu  Glu Gly Glu Asp Val  Val Thr Ser Thr Gly  Arg Gly Asn 
    1865                 1870                 1875             


Glu Ile  Gly His Ala Ser Thr  Cys Thr Gly Leu Gly  Glu Glu Ser 
    1880                 1885                 1890             


Glu Gly  Val Leu Ile Cys Glu  Ser Ala Glu Gly Asp  Ser Gln Ile 
    1895                 1900                 1905             


Gly Thr  Val Val Glu His Val  Glu Ala Glu Ala Gly  Ala Ala Ile 
    1910                 1915                 1920             


Met Asn  Ala Asn Glu Asn Asn  Val Asp Ser Met Ser  Gly Thr Glu 
    1925                 1930                 1935             


Lys Gly  Ser Lys Asp Thr Asp  Ile Cys Ser Ser Ala  Lys Gly Ile 
    1940                 1945                 1950             


Val Glu  Ser Ser Val Thr Ser  Ala Val Ser Gly Lys  Asp Glu Val 
    1955                 1960                 1965             


Thr Pro  Val Pro Gly Gly Cys  Glu Gly Pro Met Thr  Ser Ala Ala 
    1970                 1975                 1980             


Ser Asp  Gln Ser Asp Ser Gln  Leu Glu Lys Val Glu  Asp Thr Thr 
    1985                 1990                 1995             


Ile Ser  Thr Gly Leu Val Gly  Gly Ser Tyr Asp Val  Leu Val Ser 
    2000                 2005                 2010             


Gly Glu  Val Pro Glu Cys Glu  Val Ala His Thr Ser  Pro Ser Glu 
    2015                 2020                 2025             


Lys Glu  Asp Glu Asp Ile Ile  Thr Ser Val Glu Asn  Glu Glu Cys 
    2030                 2035                 2040             


Asp Gly  Leu Met Ala Thr Thr  Ala Ser Gly Asp Ile  Thr Asn Gln 
    2045                 2050                 2055             


Asn Ser  Leu Ala Gly Gly Lys  Asn Gln Gly Lys Val  Leu Ile Ile 
    2060                 2065                 2070             


Ser Thr  Ser Thr Thr Asn Asp  Tyr Thr Pro Gln Val  Ser Ala Ile 
    2075                 2080                 2085             


Thr Asp  Val Glu Gly Gly Leu  Ser Asp Ala Leu Arg  Thr Glu Glu 
    2090                 2095                 2100             


Asn Met  Glu Gly Thr Arg Val  Thr Thr Glu Glu Phe  Glu Ala Pro 
    2105                 2110                 2115             


Met Pro  Ser Ala Val Ser Gly  Asp Asp Ser Gln Leu  Thr Ala Ser 
    2120                 2125                 2130             


Arg Ser  Glu Glu Lys Asp Glu  Cys Ala Met Ile Ser  Thr Ser Ile 
    2135                 2140                 2145             


Gly Glu  Glu Phe Glu Leu Pro  Ile Ser Ser Ala Thr  Thr Ile Lys 
    2150                 2155                 2160             


Cys Ala  Glu Ser Leu Gln Pro  Val Ala Ala Ala Val  Glu Glu Arg 
    2165                 2170                 2175             


Ala Thr  Gly Pro Val Leu Ile  Ser Thr Ala Asp Phe  Glu Gly Pro 
    2180                 2185                 2190             


Met Pro  Ser Ala Pro Pro Glu  Ala Glu Ser Pro Leu  Ala Ser Thr 
    2195                 2200                 2205             


Ser Lys  Glu Glu Lys Asp Glu  Cys Ala Leu Ile Ser  Thr Ser Ile 
    2210                 2215                 2220             


Ala Glu  Glu Cys Glu Ala Ser  Val Ser Gly Val Val  Val Glu Ser 
    2225                 2230                 2235             


Glu Asn  Glu Arg Ala Gly Thr  Val Met Glu Glu Lys  Asp Gly Ser 
    2240                 2245                 2250             


Gly Ile  Ile Ser Thr Ser Ser  Val Glu Asp Cys Glu  Gly Pro Val 
    2255                 2260                 2265             


Ser Ser  Ala Val Pro Gln Glu  Glu Gly Asp Pro Ser  Val Thr Pro 
    2270                 2275                 2280             


Ala Glu  Glu Met Gly Asp Thr  Ala Met Ile Ser Thr  Ser Thr Ser 
    2285                 2290                 2295             


Glu Gly  Cys Glu Ala Val Met  Ile Gly Ala Val Leu  Gln Asp Glu 
    2300                 2305                 2310             


Asp Arg  Leu Thr Ile Thr Arg  Val Glu Asp Leu Ser  Asp Ala Ala 
    2315                 2320                 2325             


Ile Ile  Ser Thr Ser Thr Ala  Glu Cys Met Pro Ile  Ser Ala Ser 
    2330                 2335                 2340             


Ile Asp  Arg His Glu Glu Asn  Gln Leu Thr Ala Asp  Asn Pro Glu 
    2345                 2350                 2355             


Gly Asn  Gly Asp Leu Ser Ala  Thr Glu Val Ser Lys  His Lys Val 
    2360                 2365                 2370             


Pro Met  Pro Ser Leu Ile Ala  Glu Asn Asn Cys Arg  Cys Pro Gly 
    2375                 2380                 2385             


Pro Val  Arg Gly Gly Lys Glu  Pro Gly Pro Val Leu  Ala Val Ser 
    2390                 2395                 2400             


Thr Glu  Glu Gly His Asn Gly  Pro Ser Val His Lys  Pro Ser Ala 
    2405                 2410                 2415             


Gly Gln  Gly His Pro Ser Ala  Val Cys Ala Glu Lys  Glu Glu Lys 
    2420                 2425                 2430             


His Gly  Lys Glu Cys Pro Glu  Ile Gly Pro Phe Ala  Gly Arg Gly 
    2435                 2440                 2445             


Gln Lys  Glu Ser Thr Leu His  Leu Ile Asn Ala Glu  Glu Lys Asn 
    2450                 2455                 2460             


Val Leu  Leu Asn Ser Leu Gln  Lys Glu Asp Lys Ser  Pro Glu Thr 
    2465                 2470                 2475             


Gly Thr  Ala Gly Gly Ser Ser  Thr Ala Ser Tyr Ser  Ala Gly Arg 
    2480                 2485                 2490             


Gly Leu  Glu Gly Asn Ala Asn  Ser Pro Ala His Leu  Arg Gly Pro 
    2495                 2500                 2505             


Glu Gln  Thr Ser Gly Gln Thr  Ala Lys Asp Pro Ser  Val Ser Ile 
    2510                 2515                 2520             


Arg Tyr  Leu Ala Ala Val Asn  Thr Gly Ala Ile Lys  Ala Asp Asp 
    2525                 2530                 2535             


Met Pro  Pro Val Gln Gly Thr  Val Ala Glu His Ser  Phe Leu Pro 
    2540                 2545                 2550             


Ala Glu  Gln Gln Gly Ser Glu  Asp Asn Leu Lys Thr  Ser Thr Thr 
    2555                 2560                 2565             


Lys Cys  Ile Thr Gly Gln Glu  Ser Lys Ile Ala Pro  Ser His Thr 
    2570                 2575                 2580             


Met Ile  Pro Pro Ala Thr Tyr  Ser Val Ala Leu Leu  Ala Pro Lys 
    2585                 2590                 2595             


Cys Glu  Gln Asp Leu Thr Ile  Lys Asn Asp Tyr Ser  Gly Lys Trp 
    2600                 2605                 2610             


Thr Asp  Gln Ala Ser Ala Glu  Lys Thr Gly Asp Asp  Asn Ser Thr 
    2615                 2620                 2625             


Arg Lys  Ser Phe Pro Glu Glu  Gly Asp Ile Met Val  Thr Val Ser 
    2630                 2635                 2640             


Ser Glu  Glu Asn Val Cys Asp  Ile Gly Asn Glu Glu  Ser Pro Leu 
    2645                 2650                 2655             


Asn Val  Leu Gly Gly Leu Lys  Leu Lys Ala Asn Leu  Lys Met Glu 
    2660                 2665                 2670             


Ala Tyr  Val Pro Ser Glu Glu  Glu Lys Asn Gly Glu  Ile Leu Ala 
    2675                 2680                 2685             


Pro Pro  Glu Ser Leu Cys Gly  Gly Lys Pro Ser Gly  Ile Ala Glu 
    2690                 2695                 2700             


Leu Gln  Arg Glu Pro Leu Leu  Val Asn Glu Ser Leu  Asn Val Glu 
    2705                 2710                 2715             


Asn Ser  Gly Phe Arg Thr Asn  Glu Glu Ile His Ser  Glu Ser Tyr 
    2720                 2725                 2730             


Asn Lys  Gly Glu Ile Ser Ser  Gly Arg Lys Asp Asn  Ala Glu Ala 
    2735                 2740                 2745             


Ile Ser  Gly His Ser Val Glu  Ala Asp Pro Lys Glu  Val Glu Glu 
    2750                 2755                 2760             


Glu Glu  Arg His Met Pro Lys  Arg Lys Arg Lys Gln  His Tyr Leu 
    2765                 2770                 2775             


Ser Ser  Glu Asp Glu Pro Asp  Asp Asn Pro Asp Val  Leu Asp Ser 
    2780                 2785                 2790             


Arg Ile  Glu Thr Ala Gln Arg  Gln Cys Pro Glu Thr  Glu Pro His 
    2795                 2800                 2805             


Asp Thr  Lys Glu Glu Asn Ser  Arg Asp Leu Glu Glu  Leu Pro Lys 
    2810                 2815                 2820             


Thr Ser  Ser Glu Thr Asn Ser  Thr Thr Ser Arg Val  Met Glu Glu 
    2825                 2830                 2835             


Lys Asp  Glu Tyr Ser Ser Ser  Glu Thr Thr Gly Glu  Lys Pro Glu 
    2840                 2845                 2850             


Gln Asn  Asp Asp Asp Thr Ile  Lys Ser Gln Glu Glu  Asp Gln Pro 
    2855                 2860                 2865             


Ile Ile  Ile Lys Arg Lys Arg  Gly Arg Pro Arg Lys  Tyr Pro Val 
    2870                 2875                 2880             


Glu Thr  Thr Leu Lys Met Lys  Asp Asp Ser Lys Thr  Asp Thr Gly 
    2885                 2890                 2895             


Ile Val  Thr Val Glu Gln Ser  Pro Ser Ser Ser Lys  Leu Lys Val 
    2900                 2905                 2910             


Met Gln  Thr Asp Glu Ser Asn  Lys Glu Thr Ala Asn  Leu Gln Glu 
    2915                 2920                 2925             


Arg Ser  Ile Ser Asn Asp Asp  Gly Glu Glu Lys Ile  Val Thr Ser 
    2930                 2935                 2940             


Val Arg  Arg Arg Gly Arg Lys  Pro Lys Arg Ser Leu  Thr Val Ser 
    2945                 2950                 2955             


Asp Asp  Ala Glu Ser Ser Glu  Pro Glu Arg Lys Arg  Gln Lys Ser 
    2960                 2965                 2970             


Val Ser  Asp Pro Val Glu Asp  Lys Lys Glu Gln Glu  Ser Asp Glu 
    2975                 2980                 2985             


Glu Glu  Glu Glu Glu Glu Glu  Asp Glu Pro Ser Gly  Ala Thr Thr 
    2990                 2995                 3000             


Arg Ser  Thr Thr Arg Ser Glu  Ala Gln Arg Ser Lys  Thr Gln Leu 
    3005                 3010                 3015             


Ser Pro  Ser Ile Lys Arg Lys  Arg Glu Val Ser Pro  Pro Gly Ala 
    3020                 3025                 3030             


Arg Thr  Arg Gly Gln Gln Arg  Val Glu Glu Ala Pro  Val Lys Lys 
    3035                 3040                 3045             


Ala Lys  Arg 
    3050     


<210>  15
<211>  1208
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Ile Tyr Phe Glu Asp Glu 
    690                 695                 700                 


Gln Pro Ser Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly Met 
705                 710                 715                 720 


Arg Asn Ser Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro Leu 
                725                 730                 735     


Leu Ile Pro Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val Lys 
            740                 745                 750         


Lys Tyr Asp Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu Ile 
        755                 760                 765             


Glu Lys Val Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu Ser 
    770                 775                 780                 


Gly His Val Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu Ile 
785                 790                 795                 800 


Gly Leu Arg Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His Tyr 
                805                 810                 815     


His Glu Leu Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu Lys 
            820                 825                 830         


Arg Glu Trp Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu Pro 
        835                 840                 845             


Gly Thr Pro Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn Leu 
    850                 855                 860                 


Cys Asp Met Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp Asp 
865                 870                 875                 880 


Thr Ser Leu Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile Lys 
                885                 890                 895     


Ser Met Gln Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser Gln 
            900                 905                 910         


Gly Phe Thr Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser Pro 
        915                 920                 925             


Val His Gly Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn Ile 
    930                 935                 940                 


Pro Ile Ile Thr Glu Leu Ala Lys Pro Gly Lys Leu Pro Leu Val Ser 
945                 950                 955                 960 


Val Asn Gln Glu Lys Asn Ser Gly Thr His Ile Leu Met Ile Thr Glu 
                965                 970                 975     


Leu Val Asn Asp Thr Asn Val Gln Phe Leu Asp Gln Asp Asp Asp Asp 
            980                 985                 990         


Asp Pro Asp Thr Glu Leu Tyr Leu  Thr Gln Pro Phe Ala  Cys Gly Thr 
        995                 1000                 1005             


Ala Phe  Ala Val Ser Val Leu  Asp Ser Leu Met Ser  Ala Thr Tyr 
    1010                 1015                 1020             


Phe Asn  Asp Asn Ile Leu Thr  Leu Ile Arg Thr Leu  Val Thr Gly 
    1025                 1030                 1035             


Gly Ala  Thr Pro Glu Leu Glu  Ala Leu Ile Ala Glu  Glu Asn Ala 
    1040                 1045                 1050             


Leu Arg  Gly Gly Tyr Ser Thr  Pro Gln Thr Leu Ala  Asn Arg Asp 
    1055                 1060                 1065             


Arg Cys  Arg Val Ala Gln Leu  Ala Leu Leu Asp Gly  Pro Phe Ala 
    1070                 1075                 1080             


Asp Leu  Gly Asp Gly Gly Cys  Tyr Gly Asp Leu Phe  Cys Lys Ala 
    1085                 1090                 1095             


Leu Lys  Thr Tyr Asn Met Leu  Cys Phe Gly Ile Tyr  Arg Leu Arg 
    1100                 1105                 1110             


Asp Ala  His Leu Ser Thr Pro  Ser Gln Cys Thr Lys  Arg Tyr Val 
    1115                 1120                 1125             


Ile Thr  Asn Pro Pro Tyr Glu  Phe Glu Leu Val Pro  Thr Asp Leu 
    1130                 1135                 1140             


Ile Phe  Cys Leu Met Gln Phe  Asp His Asn Ala Gly  Gln Ser Arg 
    1145                 1150                 1155             


Ala Ser  Leu Ser His Ser Ser  His Ser Ser Gln Ser  Ser Ser Lys 
    1160                 1165                 1170             


Lys Ser  Ser Ser Val His Ser  Ile Pro Ser Thr Ala  Asn Arg Gln 
    1175                 1180                 1185             


Asn Arg  Pro Lys Ser Arg Glu  Ser Arg Asp Lys Gln  Lys Tyr Val 
    1190                 1195                 1200             


Gln Glu  Glu Arg Leu 
    1205             


<210>  16
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys 
145                 


<210>  17
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Asp Gln Leu Thr Glu Glu Gln Val Thr Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Arg Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Arg Asp Met Met Ser Glu Ile Asp Arg Asp Gly Asn Gly Thr Val 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Gly Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Asn Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Phe Val Ser Ala Ala Glu Leu Arg His Val Met Thr Arg 
            100                 105                 110         


Leu Gly Glu Lys Leu Ser Asp Glu Glu Val Asp Glu Met Ile Arg Ala 
        115                 120                 125             


Ala Asp Thr Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Arg 
    130                 135                 140                 


Val Leu Val Ser Lys 
145                 


<210>  18
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Gly Glu Leu Thr Pro Glu Glu Glu Ala Gln Tyr Lys Lys Ala 
1               5                   10                  15      


Phe Ser Ala Val Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu 
            20                  25                  30          


Leu Gly Ala Ala Leu Lys Ala Thr Gly Lys Asn Leu Ser Glu Ala Gln 
        35                  40                  45              


Leu Arg Lys Leu Ile Ser Glu Val Asp Ser Asp Gly Asp Gly Glu Ile 
    50                  55                  60                  


Ser Phe Gln Glu Phe Leu Thr Ala Ala Lys Lys Ala Arg Ala Gly Leu 
65                  70                  75                  80  


Glu Asp Leu Gln Val Ala Phe Arg Ala Phe Asp Gln Asp Gly Asp Gly 
                85                  90                  95      


His Ile Thr Val Asp Glu Leu Arg Arg Ala Met Ala Gly Leu Gly Gln 
            100                 105                 110         


Pro Leu Pro Gln Glu Glu Leu Asp Ala Met Ile Arg Glu Ala Asp Val 
        115                 120                 125             


Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu Phe Ala Arg Met Leu Ala 
    130                 135                 140                 


Gln Glu 
145     


<210>  19
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ser Pro Asp Trp Gly Tyr Asp Asp Lys Asn Gly Pro Glu Gln 
1               5                   10                  15      


Trp Ser Lys Leu Tyr Pro Ile Ala Asn Gly Asn Asn Gln Ser Pro Val 
            20                  25                  30          


Asp Ile Lys Thr Ser Glu Thr Lys His Asp Thr Ser Leu Lys Pro Ile 
        35                  40                  45              


Ser Val Ser Tyr Asn Pro Ala Thr Ala Lys Glu Ile Ile Asn Val Gly 
    50                  55                  60                  


His Ser Phe His Val Asn Phe Glu Asp Asn Asp Asn Arg Ser Val Leu 
65                  70                  75                  80  


Lys Gly Gly Pro Phe Ser Asp Ser Tyr Arg Leu Phe Gln Phe His Phe 
                85                  90                  95      


His Trp Gly Ser Thr Asn Glu His Gly Ser Glu His Thr Val Asp Gly 
            100                 105                 110         


Val Lys Tyr Ser Ala Glu Leu His Val Ala His Trp Asn Ser Ala Lys 
        115                 120                 125             


Tyr Ser Ser Leu Ala Glu Ala Ala Ser Lys Ala Asp Gly Leu Ala Val 
    130                 135                 140                 


Ile Gly Val Leu Met Lys Val Gly Glu Ala Asn Pro Lys Leu Gln Lys 
145                 150                 155                 160 


Val Leu Asp Ala Leu Gln Ala Ile Lys Thr Lys Gly Lys Arg Ala Pro 
                165                 170                 175     


Phe Thr Asn Phe Asp Pro Ser Thr Leu Leu Pro Ser Ser Leu Asp Phe 
            180                 185                 190         


Trp Thr Tyr Pro Gly Ser Leu Thr His Pro Pro Leu Tyr Glu Ser Val 
        195                 200                 205             


Thr Trp Ile Ile Cys Lys Glu Ser Ile Ser Val Ser Ser Glu Gln Leu 
    210                 215                 220                 


Ala Gln Phe Arg Ser Leu Leu Ser Asn Val Glu Gly Asp Asn Ala Val 
225                 230                 235                 240 


Pro Met Gln His Asn Asn Arg Pro Thr Gln Pro Leu Lys Gly Arg Thr 
                245                 250                 255     


Val Arg Ala Ser Phe 
            260     


<210>  20
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Asn Pro Arg Ser Leu Glu Glu Glu Lys Tyr Asp Met Ser Gly 
1               5                   10                  15      


Ala Arg Leu Ala Leu Ile Leu Cys Val Thr Lys Ala Arg Glu Gly Ser 
            20                  25                  30          


Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe Arg Gln Leu Arg Phe 
        35                  40                  45              


Glu Ser Thr Met Lys Arg Asp Pro Thr Ala Glu Gln Phe Gln Glu Glu 
    50                  55                  60                  


Leu Glu Lys Phe Gln Gln Ala Ile Asp Ser Arg Glu Asp Pro Val Ser 
65                  70                  75                  80  


Cys Ala Phe Val Val Leu Met Ala His Gly Arg Glu Gly Phe Leu Lys 
                85                  90                  95      


Gly Glu Asp Gly Glu Met Val Lys Leu Glu Asn Leu Phe Glu Ala Leu 
            100                 105                 110         


Asn Asn Lys Asn Cys Gln Ala Leu Arg Ala Lys Pro Lys Val Tyr Ile 
        115                 120                 125             


Ile Gln Ala Cys Arg Gly Glu Gln Arg Asp Pro Gly Glu Thr Val Gly 
    130                 135                 140                 


Gly Asp Glu Ile Val Met Val Ile Lys Asp Ser Pro Gln Thr Ile Pro 
145                 150                 155                 160 


Thr Tyr Thr Asp Ala Leu His Val Tyr Ser Thr Val Glu Gly Tyr Ile 
                165                 170                 175     


Ala Tyr Arg His Asp Gln Lys Gly Ser Cys Phe Ile Gln Thr Leu Val 
            180                 185                 190         


Asp Val Phe Thr Lys Arg Lys Gly His Ile Leu Glu Leu Leu Thr Glu 
        195                 200                 205             


Val Thr Arg Arg Met Ala Glu Ala Glu Leu Val Gln Glu Gly Lys Ala 
    210                 215                 220                 


Arg Lys Thr Asn Pro Glu Ile Gln Ser Thr Leu Arg Lys Arg Leu Tyr 
225                 230                 235                 240 


Leu Gln 
        


<210>  21
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Thr Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Thr Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Thr Gln Val Thr Thr Leu Val Asn Thr Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Thr Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val Val Glu Asp Gly 
145                 150                 155                 160 


Ile Leu Lys Leu Arg Asn Ala Gly Asn Glu Gln Asp Leu Gly Ile Gln 
                165                 170                 175     


Tyr Lys Ala Leu Lys Pro Glu Val Asp Lys Leu Asn Ile Met Ala Ala 
            180                 185                 190         


Lys Arg Gln Gln Glu Leu Lys Asp Val Gly His Arg Asp Gln Met Ala 
        195                 200                 205             


Ala Ala Arg Gly Ile Leu Gln Lys Asn Val Pro Ile Leu Tyr Thr Ala 
    210                 215                 220                 


Ser Gln Ala Cys Leu Gln His Pro Asp Val Ala Ala Tyr Lys Ala Asn 
225                 230                 235                 240 


Arg Asp Leu Ile Tyr Lys Gln Leu Gln Gln Ala Val Thr Gly Ile Ser 
                245                 250                 255     


Asn Ala Ala Gln Ala Thr Ala Ser Asp Asp Ala Ser Gln His Gln Gly 
            260                 265                 270         


Gly Gly Gly Gly Glu Leu Ala Tyr Ala Leu Asn Asn Phe Asp Lys Gln 
        275                 280                 285             


Ile Ile Val Asp Pro Leu Ser Phe Ser Glu Glu Arg Phe Arg Pro Ser 
    290                 295                 300                 


Leu Glu Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala 
305                 310                 315                 320 


Asp Ser Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu 
                325                 330                 335     


Cys Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met 
            340                 345                 350         


Gly Asn Ala Gly Arg Lys Glu Arg Ser Asp Ala Leu Asn Ser Ala Ile 
        355                 360                 365             


Asp Lys Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys 
    370                 375                 380                 


Ala Val Met Asp His Val Ser Asp Ser Phe Leu Glu Thr Asn Val Pro 
385                 390                 395                 400 


Leu Leu Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val 
                405                 410                 415     


Lys Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu 
            420                 425                 430         


Val Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys 
        435                 440                 445             


Leu Val Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val 
    450                 455                 460                 


Ile Asn Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala 
465                 470                 475                 480 


Gln Glu Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg 
                485                 490                 495     


Val Leu Thr Asp Ala Val Asp Asp Ile Thr Ser Ile Asp Asp Phe Leu 
            500                 505                 510         


Ala Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile 
        515                 520                 525             


Ala Leu Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Thr Ala Gly Ala 
    530                 535                 540                 


Ile Arg Gly Arg Ala Ala Arg Val Ile His Val Val Thr Ser Glu Met 
545                 550                 555                 560 


Asp Asn Tyr Glu Pro Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr 
                565                 570                 575     


Lys Leu Leu Ser Asn Thr Val Met Pro Arg Phe Thr Glu Gln Val Glu 
            580                 585                 590         


Ala Ala Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu 
        595                 600                 605             


Asn Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp 
    610                 615                 620                 


Ile Arg Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Thr Glu Asp Phe Asp Val Arg Ser Arg Thr Ser Val 
                645                 650                 655     


Gln Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Ala Ser Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Thr Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Gly Arg Thr Ile Ala Asp His Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Val Val Ser Gly Val Asp Ser Ala Met 
                805                 810                 815     


Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Gln Thr 
            820                 825                 830         


Val Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Ser Gln Gly 
        835                 840                 845             


Met Ala Ser Leu Asn Leu Pro Ala Val Ser Trp Lys Met Lys Ala Pro 
    850                 855                 860                 


Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Gln Asp Glu Thr Gln Thr 
865                 870                 875                 880 


Lys Ile Lys Arg Ala Ser Gln Lys Lys His Val Asn Pro Val Gln Ala 
                885                 890                 895     


Leu Ser Glu Phe Lys Ala Met Asp Ser Ile 
            900                 905     


<210>  22
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  23
<211>  3014
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Thr 
    1430                 1435                 1440             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Thr  Ile Ser Leu Thr Phe  Ala Thr Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Thr Thr  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Thr Gln  Thr Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Thr Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Thr Ser Gly Gly  Pro Thr Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Thr  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Thr  Met Thr Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Thr Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Thr Pro  Thr Asn Val Ala Thr  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Thr Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Thr Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Thr Cys  Asp Met Ala Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Thr Thr  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Thr  Thr Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Thr Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Thr Gln His Thr  Gly Thr Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Thr Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Thr Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Thr Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Thr Gly  Ala Arg Val Pro Arg  Phe Asp Thr 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Thr Thr Pro Gln Thr  Thr Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Thr Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Thr Pro 
    2360                 2365                 2370             


Met Val  Ser Thr Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Thr Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Thr Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Thr His  Val Ala Cys Gln Cys  Ser His Thr 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Thr Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Thr  Phe Ala Trp Thr Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Thr Val 
    2615                 2620                 2625             


Thr Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Thr Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2720                 2725                 2730             


Leu Thr  Arg Ser Leu Asn Cys  Asn Thr Thr Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Thr Asp Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Thr Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Thr Tyr  Pro Pro Pro Leu Thr  Leu Thr Glu 
    2930                 2935                 2940             


Gln Thr  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Thr Ser Ser Arg  Thr Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Thr Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Thr Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210>  24
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  25
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  25

Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser Thr Leu Ser 
1               5                   10                  15      


Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys Ala Glu Glu 
            20                  25                  30          


His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His Phe Pro Phe 
        35                  40                  45              


Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys Gly Arg Pro 
    50                  55                  60                  


Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp Gln Asp Gln 
65                  70                  75                  80  


Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp His Cys Ser 
                85                  90                  95      


Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn Met Pro Ser 
            100                 105                 110         


Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn His Cys Gln 
        115                 120                 125             


Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe His Lys Asn 
    130                 135                 140                 


Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg Cys Gln Cys 
145                 150                 155                 160 


Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln Ala Cys Arg 
                165                 170                 175     


Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val Glu Gly His 
            180                 185                 190         


Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Pro Phe Cys Asp Val 
        195                 200                 205             


Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser Tyr Arg Gly 
    210                 215                 220                 


Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro Trp Ala Ser 
225                 230                 235                 240 


Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg Asn Trp Gly 
                245                 250                 255     


Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp Ile Arg Pro 
            260                 265                 270         


Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu Tyr Cys Asp 
        275                 280                 285             


Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro Thr Pro Val 
    290                 295                 300                 


Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro Ala Pro Pro 
305                 310                 315                 320 


Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln Thr Pro Gly 
                325                 330                 335     


Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr Arg Asn Gly 
            340                 345                 350         


Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser Ser Met Thr 
        355                 360                 365             


Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His Pro Tyr Ile 
    370                 375                 380                 


Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser Leu Ile Ala 
385                 390                 395                 400 


Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp Arg Pro Ala 
                405                 410                 415     


Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg Asn His Ser 
            420                 425                 430         


Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg Leu His Glu 
        435                 440                 445             


Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu Leu Arg Leu 
    450                 455                 460                 


Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro Tyr Val Gln 
465                 470                 475                 480 


Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu Thr Thr Leu 
                485                 490                 495     


Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala Glu Glu Tyr 
            500                 505                 510         


Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser Leu Glu Arg 
        515                 520                 525             


Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro Gly Met Leu 
    530                 535                 540                 


Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln Gly Asp Ser 
545                 550                 555                 560 


Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg Arg Leu Thr 
                565                 570                 575     


Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg Asn Lys 
            580                 585                 590         


Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp Ile Arg Glu 
        595                 600                 605             


His Thr Val Ser 
    610         


<210>  26
<211>  1744
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Pro  Cys Pro Val Leu Asp  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  27
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Ala Cys Arg Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile 
1               5                   10                  15      


Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu Leu Thr 
            20                  25                  30          


Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg Met Ser Pro Trp 
        35                  40                  45              


Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu Arg Gln Met Phe Arg Ser 
    50                  55                  60                  


Arg Ser Ile Glu Val Phe Gly Gln Phe Asn Gly Lys Arg Cys Thr Asp 
65                  70                  75                  80  


Ala Val Gly Asp Arg Arg Gln Cys Val Pro Thr Glu Pro Cys Glu Asp 
                85                  90                  95      


Ala Glu Asp Asp Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys 
            100                 105                 110         


Ile Lys Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe 
        115                 120                 125             


Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp 
    130                 135                 140                 


Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly Ile 
145                 150                 155                 160 


Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe Asp Asn Glu Phe 
                165                 170                 175     


Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp Gly Asn Thr Leu Thr Tyr 
            180                 185                 190         


Tyr Arg Arg Pro Trp Asn Val Ala Ser Leu Ile Tyr Glu Thr Lys Gly 
        195                 200                 205             


Glu Lys Asn Phe Arg Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe 
    210                 215                 220                 


Lys Ser Ile Ile Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser 
225                 230                 235                 240 


Leu Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu 
                245                 250                 255     


Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe 
            260                 265                 270         


Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr Ser Ser 
        275                 280                 285             


Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu Ile His Leu Gly 
    290                 295                 300                 


Arg Phe Val Met Arg Asn Arg Asp Val Val Leu Thr Thr Thr Phe Val 
305                 310                 315                 320 


Asp Asp Ile Lys Ala Leu Pro Thr Thr Tyr Glu Lys Gly Glu Tyr Phe 
                325                 330                 335     


Ala Phe Leu Glu Thr Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu 
            340                 345                 350         


Gly Gly Leu Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys 
        355                 360                 365             


Arg Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His 
    370                 375                 380                 


Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe 
385                 390                 395                 400 


Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala Val Asn Ile 
                405                 410                 415     


Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser Leu Ile Arg Gly Gly 
            420                 425                 430         


Thr Arg Lys Tyr Ala Phe Glu Leu Lys Glu Lys Leu Leu Arg Gly Thr 
        435                 440                 445             


Val Ile Asp Val Thr Asp Phe Val Asn Trp Ala Ser Ser Ile Asn Asp 
    450                 455                 460                 


Ala Pro Val Leu Ile Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val 
465                 470                 475                 480 


Pro Val Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg 
                485                 490                 495     


Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr 
            500                 505                 510         


Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu Cys 
        515                 520                 525             


Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile Ser Lys Gln 
    530                 535                 540                 


Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe Pro Asn Glu Lys 
545                 550                 555                 


<210>  28
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  29
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  30
<211>  1782
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Arg Gly Phe Trp Leu Ala Glu Pro Leu Ala Gly Thr Gly Pro 
1               5                   10                  15      


His Pro Ala Pro Val Ala Ala Asp Ser Arg Gly Cys Ser Ser Val Pro 
            20                  25                  30          


Arg Arg His Ala Pro Ser Arg Leu Ser Val Ser Thr Pro Ser Arg Gly 
        35                  40                  45              


Pro Gly Ala Arg Met Val Gly Glu Leu Arg Tyr Arg Glu Phe Arg Val 
    50                  55                  60                  


Pro Leu Gly Pro Gly Leu His Ala Tyr Pro Asp Glu Leu Ile Arg Gln 
65                  70                  75                  80  


Arg Val Gly His Asp Gly His Pro Glu Tyr Gln Ile Arg Trp Leu Ile 
                85                  90                  95      


Leu Arg Arg Gly Asp Glu Gly Asp Gly Gly Ser Gly Gln Val Asp Cys 
            100                 105                 110         


Lys Ala Glu His Ile Leu Leu Trp Met Ser Lys Asp Glu Ile Tyr Ala 
        115                 120                 125             


Asn Cys His Lys Met Leu Gly Glu Asp Gly Gln Val Ile Gly Pro Ser 
    130                 135                 140                 


Gln Glu Ser Ala Gly Glu Val Gly Ala Leu Asp Lys Ser Val Leu Glu 
145                 150                 155                 160 


Glu Met Glu Thr Asp Val Lys Ser Leu Ile Gln Arg Ala Leu Arg Gln 
                165                 170                 175     


Leu Glu Glu Cys Val Gly Thr Ile Pro Pro Ala Pro Leu Leu His Thr 
            180                 185                 190         


Val His Val Leu Ser Ala Tyr Ala Ser Ile Glu Pro Leu Thr Gly Val 
        195                 200                 205             


Phe Lys Asp Pro Arg Val Leu Asp Leu Leu Met His Met Leu Ser Ser 
    210                 215                 220                 


Pro Asp Tyr Gln Ile Arg Trp Ser Ala Gly Arg Met Ile Gln Ala Leu 
225                 230                 235                 240 


Ser Ser His Asp Ala Gly Glu Gly Gln Cys Gly Glu Glu Gly Lys Ala 
                245                 250                 255     


Gly Glu Gly Leu Gly Arg Leu Arg Asp Ser Gln Asp Thr Val Ala Gly 
            260                 265                 270         


Ala Ser Asp Leu Ile Arg Thr Arg Thr Gln Ile Leu Leu Ser Leu Ser 
        275                 280                 285             


Gln Gln Glu Ala Ile Glu Lys His Leu Asp Phe Asp Ser Arg Cys Ala 
    290                 295                 300                 


Leu Leu Ala Leu Phe Ala Gln Ala Thr Leu Ser Glu His Pro Met Ser 
305                 310                 315                 320 


Phe Glu Gly Ile Gln Leu Pro Gln Val Pro Gly Arg Val Leu Phe Ser 
                325                 330                 335     


Leu Val Lys Arg Tyr Leu His Val Thr Ser Leu Leu Asp Gln Leu Asn 
            340                 345                 350         


Asp Ser Ala Ala Glu Pro Gly Ala Gln Asn Thr Ser Ala Pro Glu Glu 
        355                 360                 365             


Leu Ser Gly Glu Arg Gly Gln Leu Glu Leu Glu Phe Ser Met Ala Met 
    370                 375                 380                 


Gly Thr Leu Ile Ser Glu Leu Val Gln Ala Met Arg Trp Asp Gln Ala 
385                 390                 395                 400 


Ser Asp Arg Pro Arg Ser Ser Ala Arg Ser Pro Gly Ser Ile Phe Gln 
                405                 410                 415     


Pro Gln Leu Ala Asp Val Ser Pro Gly Leu Pro Ala Ala Gln Ala Gln 
            420                 425                 430         


Pro Ser Phe Arg Arg Ser Arg Arg Phe Arg Pro Arg Ser Glu Phe Ala 
        435                 440                 445             


Ser Gly Asn Thr Tyr Ala Leu Tyr Val Arg Asp Thr Leu Gln Pro Gly 
    450                 455                 460                 


Met Arg Val Arg Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala Gly Asp 
465                 470                 475                 480 


Glu Gly Glu Phe Arg Gln Ser Asn Asn Gly Val Pro Pro Val Gln Val 
                485                 490                 495     


Phe Trp Glu Ser Thr Gly Arg Thr Tyr Trp Val His Trp His Met Leu 
            500                 505                 510         


Glu Ile Leu Gly Phe Glu Glu Asp Ile Glu Asp Met Val Glu Ala Asp 
        515                 520                 525             


Glu Tyr Gln Gly Ala Val Ala Ser Arg Val Leu Gly Arg Ala Leu Pro 
    530                 535                 540                 


Ala Trp Arg Trp Arg Pro Met Thr Glu Leu Tyr Ala Val Pro Tyr Val 
545                 550                 555                 560 


Leu Pro Glu Asp Glu Asp Thr Glu Glu Cys Glu His Leu Thr Leu Ala 
                565                 570                 575     


Glu Trp Trp Glu Leu Leu Phe Phe Ile Lys Lys Leu Asp Gly Pro Asp 
            580                 585                 590         


His Gln Glu Val Leu Gln Ile Leu Gln Glu Asn Leu Asp Gly Glu Ile 
        595                 600                 605             


Leu Asp Asp Glu Ile Leu Ala Glu Leu Ala Val Pro Ile Glu Leu Ala 
    610                 615                 620                 


Gln Asp Leu Leu Leu Thr Leu Pro Gln Arg Leu Asn Asp Ser Ala Leu 
625                 630                 635                 640 


Arg Asp Leu Ile Asn Cys His Val Tyr Lys Lys Tyr Gly Pro Glu Ala 
                645                 650                 655     


Leu Ala Gly Asn Gln Ala Tyr Pro Ser Leu Leu Glu Ala Gln Glu Asp 
            660                 665                 670         


Val Leu Leu Leu Asp Ala Gln Ala Gln Ala Lys Asp Ser Glu Asp Ala 
        675                 680                 685             


Ala Lys Val Glu Ala Lys Glu Pro Pro Ser Gln Ser Pro Asn Thr Pro 
    690                 695                 700                 


Leu Gln Arg Leu Val Glu Gly Tyr Gly Pro Ala Gly Lys Ile Leu Leu 
705                 710                 715                 720 


Asp Leu Glu Gln Ala Leu Ser Ser Glu Gly Thr Gln Glu Asn Lys Val 
                725                 730                 735     


Lys Pro Leu Leu Leu Gln Leu Gln Arg Gln Pro Gln Pro Phe Leu Ala 
            740                 745                 750         


Leu Met Gln Ser Leu Asp Thr Pro Glu Thr Asn Arg Thr Leu His Leu 
        755                 760                 765             


Thr Val Leu Arg Ile Leu Lys Gln Leu Val Asp Phe Pro Glu Ala Leu 
    770                 775                 780                 


Leu Leu Pro Trp His Glu Ala Val Asp Ala Cys Met Ala Cys Leu Arg 
785                 790                 795                 800 


Ser Pro Asn Thr Asp Arg Glu Val Leu Gln Glu Leu Ile Phe Phe Leu 
                805                 810                 815     


His Arg Leu Thr Ser Val Ser Arg Asp Tyr Ala Val Val Leu Asn Gln 
            820                 825                 830         


Leu Gly Ala Arg Asp Ala Ile Ser Lys Ala Leu Glu Lys His Leu Gly 
        835                 840                 845             


Lys Leu Glu Leu Ala Gln Glu Leu Arg Asp Met Val Phe Lys Cys Glu 
    850                 855                 860                 


Lys His Ala His Leu Tyr Arg Lys Leu Ile Thr Asn Ile Leu Gly Gly 
865                 870                 875                 880 


Cys Ile Gln Met Val Leu Gly Gln Ile Glu Asp His Arg Arg Thr His 
                885                 890                 895     


Gln Pro Ile Asn Ile Pro Phe Phe Asp Val Phe Leu Arg Tyr Leu Cys 
            900                 905                 910         


Gln Gly Ser Ser Val Glu Val Lys Glu Asp Lys Cys Trp Glu Lys Val 
        915                 920                 925             


Glu Val Ser Ser Asn Pro His Arg Ala Ser Lys Leu Thr Asp His Asn 
    930                 935                 940                 


Pro Lys Thr Tyr Trp Glu Ser Asn Gly Ser Ala Gly Ser His Tyr Ile 
945                 950                 955                 960 


Thr Leu His Met Arg Arg Gly Ile Leu Ile Arg Gln Leu Thr Leu Leu 
                965                 970                 975     


Val Ala Ser Glu Asp Ser Ser Tyr Met Pro Ala Arg Val Val Val Cys 
            980                 985                 990         


Gly Gly Asp Ser Thr Ser Ser Leu  His Thr Glu Leu Asn  Ser Val Asn 
        995                 1000                 1005             


Val Met  Pro Ser Ala Ser Arg  Val Ile Leu Leu Glu  Asn Leu Thr 
    1010                 1015                 1020             


Arg Phe  Trp Pro Ile Ile Gln  Ile Arg Ile Lys Arg  Cys Gln Gln 
    1025                 1030                 1035             


Gly Gly  Ile Asp Thr Arg Ile  Arg Gly Leu Glu Ile  Leu Gly Pro 
    1040                 1045                 1050             


Lys Pro  Thr Phe Trp Pro Val  Phe Arg Glu Gln Leu  Cys Arg His 
    1055                 1060                 1065             


Thr Arg  Leu Phe Tyr Met Val  Arg Ala Gln Ala Trp  Ser Gln Asp 
    1070                 1075                 1080             


Met Ala  Glu Asp Arg Arg Ser  Leu Leu His Leu Ser  Ser Arg Leu 
    1085                 1090                 1095             


Asn Gly  Ala Leu Arg Gln Glu  Gln Asn Phe Ala Asp  Arg Phe Leu 
    1100                 1105                 1110             


Pro Asp  Asp Glu Ala Ala Gln  Ala Leu Gly Lys Thr  Cys Trp Glu 
    1115                 1120                 1125             


Ala Leu  Val Ser Pro Val Val  Gln Asn Ile Thr Ser  Pro Asp Glu 
    1130                 1135                 1140             


Asp Gly  Ile Ser Pro Leu Gly  Trp Leu Leu Asp Gln  Tyr Leu Glu 
    1145                 1150                 1155             


Cys Gln  Glu Ala Val Phe Asn  Pro Gln Ser Arg Gly  Pro Ala Phe 
    1160                 1165                 1170             


Phe Ser  Arg Val Arg Arg Leu  Thr His Leu Leu Val  His Val Glu 
    1175                 1180                 1185             


Pro Cys  Glu Ala Pro Pro Pro  Val Val Ala Thr Pro  Arg Pro Lys 
    1190                 1195                 1200             


Gly Arg  Asn Arg Ser His Asp  Trp Ser Ser Leu Ala  Thr Arg Gly 
    1205                 1210                 1215             


Leu Pro  Ser Ser Ile Met Arg  Asn Leu Thr Arg Cys  Trp Arg Ala 
    1220                 1225                 1230             


Val Val  Glu Lys Gln Val Asn  Asn Phe Leu Thr Ser  Ser Trp Arg 
    1235                 1240                 1245             


Asp Asp  Asp Phe Val Pro Arg  Tyr Cys Glu His Phe  Asn Ile Leu 
    1250                 1255                 1260             


Gln Asn  Ser Ser Ser Glu Leu  Phe Gly Pro Arg Ala  Ala Phe Leu 
    1265                 1270                 1275             


Leu Ala  Leu Gln Asn Gly Cys  Ala Gly Ala Leu Leu  Lys Leu Pro 
    1280                 1285                 1290             


Phe Leu  Lys Ala Ala His Val  Ser Glu Gln Phe Ala  Arg His Ile 
    1295                 1300                 1305             


Asp Gln  Gln Ile Gln Gly Ser  Arg Ile Gly Gly Ala  Gln Glu Met 
    1310                 1315                 1320             


Glu Arg  Leu Ala Gln Leu Gln  Gln Cys Leu Gln Ala  Val Leu Ile 
    1325                 1330                 1335             


Phe Ser  Gly Leu Glu Ile Ala  Thr Thr Phe Glu His  Tyr Tyr Gln 
    1340                 1345                 1350             


His Tyr  Met Ala Asp Arg Leu  Leu Gly Val Val Ser  Ser Trp Leu 
    1355                 1360                 1365             


Glu Gly  Ala Val Leu Glu Gln  Ile Gly Pro Cys Phe  Pro Asn Arg 
    1370                 1375                 1380             


Leu Pro  Gln Gln Met Leu Gln  Ser Leu Ser Thr Ser  Lys Glu Leu 
    1385                 1390                 1395             


Gln Arg  Gln Phe His Val Tyr  Gln Leu Gln Gln Leu  Asp Gln Glu 
    1400                 1405                 1410             


Leu Leu  Lys Leu Glu Asp Thr  Glu Lys Lys Ile Gln  Val Gly Leu 
    1415                 1420                 1425             


Gly Ala  Ser Gly Lys Glu His  Lys Ser Glu Lys Glu  Glu Glu Ala 
    1430                 1435                 1440             


Gly Ala  Ala Ala Val Val Asp  Val Ala Glu Gly Glu  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Asn Glu Asp Leu Tyr  Tyr Glu Gly Ala Met  Pro Glu Val 
    1460                 1465                 1470             


Ser Val  Leu Val Leu Ser Arg  His Ser Trp Pro Val  Ala Ser Ile 
    1475                 1480                 1485             


Cys His  Thr Leu Asn Pro Arg  Thr Cys Leu Pro Ser  Tyr Leu Arg 
    1490                 1495                 1500             


Gly Thr  Leu Asn Arg Tyr Ser  Asn Phe Tyr Asn Lys  Ser Gln Ser 
    1505                 1510                 1515             


His Pro  Ala Leu Glu Arg Gly  Ser Gln Arg Arg Leu  Gln Trp Thr 
    1520                 1525                 1530             


Trp Leu  Gly Trp Ala Glu Leu  Gln Phe Gly Asn Gln  Thr Leu His 
    1535                 1540                 1545             


Val Ser  Thr Val Gln Met Trp  Leu Leu Leu Tyr Leu  Asn Asp Leu 
    1550                 1555                 1560             


Lys Ala  Val Ser Val Glu Ser  Leu Leu Ala Phe Ser  Gly Leu Ser 
    1565                 1570                 1575             


Ala Asp  Met Leu Asn Gln Ala  Ile Gly Pro Leu Thr  Ser Ser Arg 
    1580                 1585                 1590             


Gly Pro  Leu Asp Leu His Glu  Gln Lys Asp Ile Pro  Gly Gly Val 
    1595                 1600                 1605             


Leu Lys  Ile Arg Asp Gly Ser  Lys Glu Pro Arg Ser  Arg Trp Asp 
    1610                 1615                 1620             


Ile Val  Arg Leu Ile Pro Pro  Gln Thr Tyr Leu Gln  Ala Glu Gly 
    1625                 1630                 1635             


Glu Asp  Gly Gln Asn Leu Glu  Lys Arg Arg Asn Leu  Leu Asn Cys 
    1640                 1645                 1650             


Leu Ile  Val Arg Ile Leu Lys  Ala His Gly Asp Glu  Gly Leu His 
    1655                 1660                 1665             


Ile Asp  Gln Leu Val Cys Leu  Val Leu Glu Ala Trp  Gln Lys Gly 
    1670                 1675                 1680             


Pro Cys  Pro Pro Arg Gly Leu  Val Ser Ser Leu Gly  Lys Gly Ser 
    1685                 1690                 1695             


Ala Cys  Ser Ser Thr Asp Val  Leu Ser Cys Ile Leu  His Leu Leu 
    1700                 1705                 1710             


Gly Lys  Gly Thr Leu Arg Arg  His Asp Asp Arg Pro  Gln Val Leu 
    1715                 1720                 1725             


Ser Tyr  Ala Val Pro Val Thr  Val Met Glu Pro His  Thr Glu Ser 
    1730                 1735                 1740             


Leu Asn  Pro Gly Ser Ser Gly  Pro Asn Pro Pro Leu  Thr Phe His 
    1745                 1750                 1755             


Thr Leu  Gln Ile Arg Ser Arg  Gly Val Pro Tyr Ala  Ser Cys Thr 
    1760                 1765                 1770             


Ala Thr  Gln Ser Phe Ser Thr  Phe Arg 
    1775                 1780         


<210>  31
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Leu Ala Ser Ala Ala Pro Gly Ser Ile Phe Cys Lys Gln Leu 
1               5                   10                  15      


Leu Phe Ser Leu Leu Val Leu Thr Leu Leu Cys Asp Ala Cys Gln Lys 
            20                  25                  30          


Val Tyr Leu Arg Val Pro Ser His Leu Gln Ala Glu Thr Leu Val Gly 
        35                  40                  45              


Lys Val Asn Leu Glu Glu Cys Leu Lys Ser Ala Ser Leu Ile Arg Ser 
    50                  55                  60                  


Ser Asp Pro Ala Phe Arg Ile Leu Glu Asp Gly Ser Ile Tyr Thr Thr 
65                  70                  75                  80  


His Asp Leu Ile Leu Ser Ser Glu Arg Lys Ser Phe Ser Ile Phe Leu 
                85                  90                  95      


Ser Asp Gly Gln Arg Arg Glu Gln Gln Glu Ile Lys Val Val Leu Ser 
            100                 105                 110         


Ala Arg Glu Asn Lys Ser Pro Lys Lys Arg His Thr Lys Asp Thr Ala 
        115                 120                 125             


Leu Lys Arg Ser Lys Arg Arg Trp Ala Pro Ile Pro Ala Ser Leu Met 
    130                 135                 140                 


Glu Asn Ser Leu Gly Pro Phe Pro Gln His Val Gln Gln Ile Gln Ser 
145                 150                 155                 160 


Asp Ala Ala Gln Asn Tyr Thr Ile Phe Tyr Ser Ile Ser Gly Pro Gly 
                165                 170                 175     


Val Asp Lys Glu Pro Phe Asn Leu Phe Tyr Ile Glu Lys Asp Thr Gly 
            180                 185                 190         


Asp Ile Phe Cys Thr Arg Ser Ile Asp Arg Glu Lys Tyr Glu Gln Phe 
        195                 200                 205             


Ala Leu Tyr Gly Tyr Ala Thr Thr Ala Asp Gly Tyr Ala Pro Glu Tyr 
    210                 215                 220                 


Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Asp Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Tyr Phe Glu His Arg Val Thr Ile Phe Thr Val Pro Glu Asn Cys Arg 
                245                 250                 255     


Ser Gly Thr Ser Val Gly Lys Val Thr Ala Thr Asp Leu Asp Glu Pro 
            260                 265                 270         


Asp Thr Leu His Thr Arg Leu Lys Tyr Lys Ile Leu Gln Gln Ile Pro 
        275                 280                 285             


Asp His Pro Lys His Phe Ser Ile His Pro Asp Thr Gly Val Ile Thr 
    290                 295                 300                 


Thr Thr Thr Pro Phe Leu Asp Arg Glu Lys Cys Asp Thr Tyr Gln Leu 
305                 310                 315                 320 


Ile Met Glu Val Arg Asp Met Gly Gly Gln Pro Phe Gly Leu Phe Asn 
                325                 330                 335     


Thr Gly Thr Ile Thr Ile Ser Leu Glu Asp Glu Asn Asp Asn Pro Pro 
            340                 345                 350         


Ser Phe Thr Glu Thr Ser Tyr Val Thr Glu Val Glu Glu Asn Arg Ile 
        355                 360                 365             


Asp Val Glu Ile Leu Arg Met Lys Val Gln Asp Gln Asp Leu Pro Asn 
    370                 375                 380                 


Thr Pro His Ser Lys Ala Val Tyr Lys Ile Leu Gln Gly Asn Glu Asn 
385                 390                 395                 400 


Gly Asn Phe Ile Ile Ser Thr Asp Pro Asn Thr Asn Glu Gly Val Leu 
                405                 410                 415     


Cys Val Val Lys Pro Leu Asn Tyr Glu Val Asn Arg Gln Val Ile Leu 
            420                 425                 430         


Gln Val Gly Val Ile Asn Glu Ala Gln Phe Ser Lys Ala Ala Ser Ser 
        435                 440                 445             


Gln Thr Pro Thr Met Cys Thr Thr Thr Val Thr Val Lys Ile Ile Asp 
    450                 455                 460                 


Ser Asp Glu Gly Pro Glu Cys His Pro Pro Val Lys Val Ile Gln Ser 
465                 470                 475                 480 


Gln Asp Gly Phe Pro Ala Gly Gln Glu Leu Leu Gly Tyr Lys Ala Leu 
                485                 490                 495     


Asp Pro Glu Ile Ser Ser Gly Glu Gly Leu Arg Tyr Gln Lys Leu Gly 
            500                 505                 510         


Asp Glu Asp Asn Trp Phe Glu Ile Asn Gln His Thr Gly Asp Leu Arg 
        515                 520                 525             


Thr Leu Lys Val Leu Asp Arg Glu Ser Lys Phe Val Lys Asn Asn Gln 
    530                 535                 540                 


Tyr Asn Ile Ser Val Val Ala Val Asp Ala Val Gly Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Val Val His Leu Asp Asp Tyr Asn Asp His Ala Pro Gln 
                565                 570                 575     


Ile Asp Lys Glu Val Thr Ile Cys Gln Asn Asn Glu Asp Phe Ala Val 
            580                 585                 590         


Leu Lys Pro Val Asp Pro Asp Gly Pro Glu Asn Gly Pro Pro Phe Gln 
        595                 600                 605             


Phe Phe Leu Asp Asn Ser Ala Ser Lys Asn Trp Asn Ile Glu Glu Lys 
    610                 615                 620                 


Asp Gly Lys Thr Ala Ile Leu Arg Gln Arg Gln Asn Leu Asp Tyr Asn 
625                 630                 635                 640 


Tyr Tyr Ser Val Pro Ile Gln Ile Lys Asp Arg His Gly Leu Val Ala 
                645                 650                 655     


Thr His Met Leu Thr Val Arg Val Cys Asp Cys Ser Thr Pro Ser Glu 
            660                 665                 670         


Cys Arg Met Lys Asp Lys Ser Thr Arg Asp Val Arg Pro Asn Val Ile 
        675                 680                 685             


Leu Gly Arg Trp Ala Ile Leu Ala Met Val Leu Gly Ser Val Leu Leu 
    690                 695                 700                 


Leu Cys Ile Leu Phe Thr Cys Phe Cys Val Thr Ala Lys Arg Thr Val 
705                 710                 715                 720 


Lys Lys Cys Phe Pro Glu Asp Ile Ala Gln Gln Asn Leu Ile Val Ser 
                725                 730                 735     


Asn Thr Glu Gly Pro Gly Glu Glu Val Thr Glu Ala Asn Ile Arg Leu 
            740                 745                 750         


Pro Met Gln Thr Ser Asn Ile Cys Asp Thr Ser Met Ser Val Gly Thr 
        755                 760                 765             


Val Gly Gly Gln Gly Ile Lys Thr Gln Gln Ser Phe Glu Met Val Lys 
    770                 775                 780                 


Gly Gly Tyr Thr Leu Asp Ser Asn Lys Gly Gly Gly His Gln Thr Leu 
785                 790                 795                 800 


Glu Ser Val Lys Gly Val Gly Gln Gly Asp Thr Gly Arg Tyr Ala Tyr 
                805                 810                 815     


Thr Asp Trp Gln Ser Phe Thr Gln Pro Arg Leu Gly Glu Lys Val Tyr 
            820                 825                 830         


Leu Cys Gly Gln Asp Glu Glu His Lys His Cys Glu Asp Tyr Val Cys 
        835                 840                 845             


Ser Tyr Asn Tyr Glu Gly Lys Gly Ser Leu Ala Gly Ser Val Gly Cys 
    850                 855                 860                 


Cys Ser Asp Arg Gln Glu Glu Glu Gly Leu Glu Phe Leu Asp His Leu 
865                 870                 875                 880 


Glu Pro Lys Phe Arg Thr Leu Ala Lys Thr Cys Ile Lys Lys 
                885                 890                 


<210>  32
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  33
<211>  1401
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Gly Asp Ser Ser Ser Ser Ser Gly Gly Ser Gly Pro Ala Pro 
1               5                   10                  15      


Gly Pro Gly Pro Glu Gly Glu Gln Arg Pro Glu Gly Glu Pro Leu Ala 
            20                  25                  30          


Pro Asp Gly Gly Ser Pro Asp Ser Thr Gln Thr Lys Ala Val Pro Pro 
        35                  40                  45              


Glu Ala Ser Pro Glu Arg Ser Cys Ser Leu His Ser Cys Pro Leu Glu 
    50                  55                  60                  


Asp Pro Ser Ser Ser Ser Gly Pro Pro Pro Thr Thr Ser Thr Leu Gln 
65                  70                  75                  80  


Pro Val Gly Pro Ser Ser Pro Leu Ala Pro Ala His Phe Thr Tyr Pro 
                85                  90                  95      


Arg Ala Leu Gln Glu Tyr Gln Gly Gly Ser Ser Leu Pro Gly Leu Gly 
            100                 105                 110         


Asp Arg Ala Ala Leu Cys Ser His Gly Ser Ser Leu Ser Pro Ser Pro 
        115                 120                 125             


Ala Pro Ser Gln Arg Asp Gly Thr Trp Lys Pro Pro Ala Val Gln His 
    130                 135                 140                 


His Val Val Ser Val Arg Gln Glu Arg Ala Phe Gln Met Pro Lys Ser 
145                 150                 155                 160 


Tyr Ser Gln Leu Ile Ala Glu Trp Pro Val Ala Val Leu Met Leu Cys 
                165                 170                 175     


Leu Ala Val Ile Phe Leu Cys Thr Leu Ala Gly Leu Leu Gly Ala Arg 
            180                 185                 190         


Leu Pro Asp Phe Ser Lys Pro Leu Leu Gly Phe Glu Pro Arg Asp Thr 
        195                 200                 205             


Asp Ile Gly Ser Lys Leu Val Val Trp Arg Ala Leu Gln Ala Leu Thr 
    210                 215                 220                 


Gly Pro Arg Lys Leu Leu Phe Leu Ser Pro Asp Leu Glu Leu Asn Ser 
225                 230                 235                 240 


Ser Ser Ser His Asn Thr Leu Arg Pro Ala Pro Arg Gly Ser Ala Gln 
                245                 250                 255     


Glu Ser Ala Val Arg Pro Arg Arg Met Val Glu Pro Leu Glu Asp Arg 
            260                 265                 270         


Arg Gln Glu Asn Phe Phe Cys Gly Pro Pro Glu Lys Ser Tyr Ala Lys 
        275                 280                 285             


Leu Val Phe Met Ser Thr Ser Ser Gly Ser Leu Trp Asn Leu His Ala 
    290                 295                 300                 


Ile His Ser Met Cys Arg Met Glu Gln Asp Gln Ile Arg Ser His Thr 
305                 310                 315                 320 


Ser Phe Gly Ala Leu Cys Gln Arg Thr Ala Ala Asn Gln Cys Cys Pro 
                325                 330                 335     


Ser Trp Ser Leu Gly Asn Tyr Leu Ala Val Leu Ser Asn Arg Ser Ser 
            340                 345                 350         


Cys Leu Asp Thr Thr Gln Ala Asp Ala Ala Arg Thr Leu Ala Leu Leu 
        355                 360                 365             


Arg Thr Cys Ala Leu Tyr Tyr His Ser Gly Ala Leu Val Pro Ser Cys 
    370                 375                 380                 


Leu Gly Pro Gly Gln Asn Lys Ser Pro Arg Cys Ala Gln Val Pro Thr 
385                 390                 395                 400 


Lys Cys Ser Gln Ser Ser Ala Ile Tyr Gln Leu Leu His Phe Leu Leu 
                405                 410                 415     


Asp Arg Asp Phe Leu Ser Pro Gln Thr Thr Asp Tyr Gln Val Pro Ser 
            420                 425                 430         


Leu Lys Tyr Ser Leu Leu Phe Leu Pro Thr Pro Lys Gly Ala Ser Leu 
        435                 440                 445             


Met Asp Ile Tyr Leu Asp Arg Leu Ala Thr Pro Trp Gly Leu Ala Asp 
    450                 455                 460                 


Asn Tyr Thr Ser Val Thr Gly Met Asp Leu Gly Leu Lys Gln Glu Leu 
465                 470                 475                 480 


Leu Arg His Phe Leu Val Gln Asp Thr Val Tyr Pro Leu Leu Ala Leu 
                485                 490                 495     


Val Ala Ile Phe Phe Gly Met Ala Leu Tyr Leu Arg Ser Leu Phe Leu 
            500                 505                 510         


Thr Leu Met Val Leu Leu Gly Val Leu Gly Ser Leu Leu Val Ala Phe 
        515                 520                 525             


Phe Leu Tyr Gln Val Ala Phe Arg Met Ala Tyr Phe Pro Phe Val Asn 
    530                 535                 540                 


Leu Ala Ala Leu Leu Leu Leu Ser Ser Val Cys Ala Asn His Thr Leu 
545                 550                 555                 560 


Ile Phe Phe Asp Leu Trp Arg Leu Ser Lys Ser Gln Leu Pro Ser Gly 
                565                 570                 575     


Gly Leu Ala Gln Arg Val Gly Arg Thr Met His His Phe Gly Tyr Leu 
            580                 585                 590         


Leu Leu Val Ser Gly Leu Thr Thr Ser Ala Ala Phe Tyr Ala Ser Tyr 
        595                 600                 605             


Leu Ser Arg Leu Pro Ala Val Arg Cys Leu Ala Leu Phe Met Gly Thr 
    610                 615                 620                 


Ala Val Leu Val His Leu Ala Leu Thr Leu Val Trp Leu Pro Ala Ser 
625                 630                 635                 640 


Ala Val Leu His Glu Arg Tyr Leu Ala Arg Gly Cys Ala Arg Arg Ala 
                645                 650                 655     


Arg Gly Arg Trp Glu Gly Ser Ala Pro Arg Arg Leu Leu Leu Ala Leu 
            660                 665                 670         


His Arg Arg Leu Arg Gly Leu Arg Arg Ala Ala Ala Gly Thr Ser Arg 
        675                 680                 685             


Leu Leu Phe Gln Arg Leu Leu Pro Cys Gly Val Ile Lys Phe Arg Tyr 
    690                 695                 700                 


Ile Trp Ile Cys Trp Phe Ala Ala Leu Ala Ala Gly Gly Ala Tyr Ile 
705                 710                 715                 720 


Ala Gly Val Ser Pro Arg Leu Arg Leu Pro Thr Leu Pro Pro Pro Gly 
                725                 730                 735     


Gly Gln Val Phe Arg Pro Ser His Pro Phe Glu Arg Phe Asp Ala Glu 
            740                 745                 750         


Tyr Arg Gln Leu Phe Leu Phe Glu Gln Leu Pro Gln Gly Glu Gly Gly 
        755                 760                 765             


His Met Pro Val Val Leu Val Trp Gly Val Leu Pro Val Asp Thr Gly 
    770                 775                 780                 


Asp Pro Leu Asp Pro Arg Ser Asn Ser Ser Leu Val Arg Asp Pro Ala 
785                 790                 795                 800 


Phe Ser Ala Ser Gly Pro Glu Ala Gln Arg Trp Leu Leu Ala Leu Cys 
                805                 810                 815     


His Arg Ala Arg Asn Gln Ser Phe Phe Asp Thr Leu Gln Glu Gly Trp 
            820                 825                 830         


Pro Thr Leu Cys Phe Val Glu Thr Leu Gln Arg Trp Met Glu Ser Pro 
        835                 840                 845             


Ser Cys Ala Arg Leu Gly Pro Asp Leu Cys Cys Gly His Ser Asp Phe 
    850                 855                 860                 


Pro Trp Ala Pro Gln Phe Phe Leu His Cys Leu Lys Met Met Ala Leu 
865                 870                 875                 880 


Glu Gln Gly Pro Asp Gly Thr Gln Asp Leu Gly Leu Arg Phe Asp Ala 
                885                 890                 895     


His Gly Ser Leu Ala Ala Leu Val Leu Gln Phe Gln Thr Asn Phe Arg 
            900                 905                 910         


Asn Ser Pro Asp Tyr Asn Gln Thr Gln Leu Phe Tyr Asn Glu Val Ser 
        915                 920                 925             


His Trp Leu Ala Ala Glu Leu Gly Met Ala Pro Pro Gly Leu Arg Arg 
    930                 935                 940                 


Gly Trp Phe Thr Ser Arg Leu Glu Leu Tyr Ser Leu Gln His Ser Leu 
945                 950                 955                 960 


Ser Thr Glu Pro Ala Val Val Leu Gly Leu Ala Leu Ala Leu Ala Phe 
                965                 970                 975     


Ala Thr Leu Leu Leu Gly Thr Trp Asn Val Pro Leu Ser Leu Phe Ser 
            980                 985                 990         


Val Ala Ala Val Ala Gly Thr Val  Leu Leu Thr Val Gly  Leu Leu Val 
        995                 1000                 1005             


Leu Leu  Glu Trp Gln Leu Asn  Thr Ala Glu Ala Leu  Phe Leu Ser 
    1010                 1015                 1020             


Ala Ser  Val Gly Leu Ser Val  Asp Phe Thr Val Asn  Tyr Cys Ile 
    1025                 1030                 1035             


Ser Tyr  His Leu Cys Pro His  Pro Asp Arg Leu Ser  Arg Val Ala 
    1040                 1045                 1050             


Phe Ser  Leu Arg Gln Thr Ser  Cys Ala Thr Ala Val  Gly Ala Ala 
    1055                 1060                 1065             


Ala Leu  Phe Ala Ala Gly Val  Leu Met Leu Pro Ala  Thr Val Leu 
    1070                 1075                 1080             


Leu Tyr  Arg Lys Leu Gly Ile  Ile Leu Met Met Val  Lys Cys Val 
    1085                 1090                 1095             


Ser Cys  Gly Phe Ala Ser Phe  Phe Phe Gln Ser Leu  Cys Cys Phe 
    1100                 1105                 1110             


Phe Gly  Pro Glu Lys Asn Cys  Gly Gln Ile Leu Trp  Pro Cys Ala 
    1115                 1120                 1125             


His Leu  Pro Trp Asp Ala Gly  Thr Gly Asp Pro Gly  Gly Glu Lys 
    1130                 1135                 1140             


Ala Gly  Arg Pro Arg Pro Gly  Ser Val Gly Gly Met  Pro Gly Ser 
    1145                 1150                 1155             


Cys Ser  Glu Gln Tyr Glu Leu  Gln Pro Leu Ala Arg  Arg Arg Ser 
    1160                 1165                 1170             


Pro Ser  Phe Asp Thr Ser Thr  Ala Thr Ser Lys Leu  Ser His Arg 
    1175                 1180                 1185             


Pro Ser  Val Leu Ser Glu Asp  Leu Gln Leu His Asp  Gly Pro Cys 
    1190                 1195                 1200             


Cys Ser  Arg Pro Pro Pro Ala  Pro Ala Ser Pro Arg  Glu Leu Leu 
    1205                 1210                 1215             


Leu Asp  His Gln Ala Val Phe  Ser Gln Cys Pro Ala  Leu Gln Thr 
    1220                 1225                 1230             


Ser Ser  Pro Tyr Lys Gln Ala  Gly Pro Ser Pro Lys  Thr Arg Ala 
    1235                 1240                 1245             


Arg Gln  Asp Ser Gln Gly Glu  Glu Ala Glu Pro Leu  Pro Ala Ser 
    1250                 1255                 1260             


Pro Glu  Ala Pro Ala His Ser  Pro Lys Ala Lys Ala  Ala Asp Pro 
    1265                 1270                 1275             


Pro Asp  Gly Phe Cys Ser Ser  Ala Ser Thr Leu Glu  Gly Leu Ser 
    1280                 1285                 1290             


Val Ser  Asp Glu Thr Cys Leu  Ser Thr Ser Glu Pro  Ser Ala Arg 
    1295                 1300                 1305             


Val Pro  Asp Ser Val Gly Val  Ser Pro Asp Asp Leu  Asp Asp Thr 
    1310                 1315                 1320             


Gly Gln  Pro Val Leu Glu Arg  Gly Gln Leu Asn Gly  Lys Arg Asp 
    1325                 1330                 1335             


Thr Leu  Trp Leu Ala Leu Arg  Glu Thr Val Tyr Asp  Pro Ser Leu 
    1340                 1345                 1350             


Pro Ala  Ser His His Ser Ser  Leu Ser Trp Lys Gly  Arg Gly Gly 
    1355                 1360                 1365             


Pro Gly  Asp Gly Ser Pro Val  Val Leu Pro Asn Ser  Gln Pro Asp 
    1370                 1375                 1380             


Leu Pro  Asp Val Trp Leu Arg  Arg Pro Ser Thr His  Thr Ser Gly 
    1385                 1390                 1395             


Tyr Ser  Ser 
    1400     


<210>  34
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  35
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Thr Val Gln Gln Leu Glu Gly Arg Trp Arg Leu Val Asp Ser 
1               5                   10                  15      


Lys Gly Phe Asp Glu Tyr Met Lys Glu Leu Gly Val Gly Ile Ala Leu 
            20                  25                  30          


Arg Lys Met Gly Ala Met Ala Lys Pro Asp Cys Ile Ile Thr Cys Asp 
        35                  40                  45              


Gly Lys Asn Leu Thr Ile Lys Thr Glu Ser Thr Leu Lys Thr Thr Gln 
    50                  55                  60                  


Phe Ser Cys Thr Leu Gly Glu Lys Phe Glu Glu Thr Thr Ala Asp Gly 
65                  70                  75                  80  


Arg Lys Thr Gln Thr Val Cys Asn Phe Thr Asp Gly Ala Leu Val Gln 
                85                  90                  95      


His Gln Glu Trp Asp Gly Lys Glu Ser Thr Ile Thr Arg Lys Leu Lys 
            100                 105                 110         


Asp Gly Lys Leu Val Val Glu Cys Val Met Asn Asn Val Thr Cys Thr 
        115                 120                 125             


Arg Ile Tyr Glu Lys Val Glu 
    130                 135 


<210>  36
<211>  1322
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Val Phe Ser Phe Val Lys Ile Ala Lys Leu Ser Ser His Arg 
1               5                   10                  15      


Thr Lys Ser Ser Gly Trp Pro Pro Pro Ser Gly Thr Trp Gly Leu Ser 
            20                  25                  30          


Gln Val Pro Pro Tyr Gly Trp Glu Met Thr Ala Asn Arg Asp Gly Arg 
        35                  40                  45              


Asp Tyr Phe Ile Asn His Met Thr Gln Ala Ile Pro Phe Asp Asp Pro 
    50                  55                  60                  


Arg Leu Glu Ser Cys Gln Ile Ile Pro Pro Ala Pro Arg Lys Val Glu 
65                  70                  75                  80  


Met Arg Arg Asp Pro Val Leu Gly Phe Gly Phe Val Ala Gly Ser Glu 
                85                  90                  95      


Lys Pro Val Val Val Arg Ser Val Thr Pro Gly Gly Pro Ser Glu Gly 
            100                 105                 110         


Lys Leu Ile Pro Gly Asp Gln Ile Val Met Ile Asn Asp Glu Pro Val 
        115                 120                 125             


Ser Ala Ala Pro Arg Glu Arg Val Ile Asp Leu Val Arg Ser Cys Lys 
    130                 135                 140                 


Glu Ser Ile Leu Leu Thr Val Ile Gln Pro Tyr Pro Ser Pro Lys Ser 
145                 150                 155                 160 


Ala Phe Ile Ser Ala Ala Lys Lys Ala Arg Leu Lys Ser Asn Pro Val 
                165                 170                 175     


Lys Val Arg Phe Ser Glu Glu Val Ile Ile Asn Gly Gln Val Ser Glu 
            180                 185                 190         


Thr Val Lys Asp Asn Ser Leu Leu Phe Met Pro Asn Val Leu Lys Val 
        195                 200                 205             


Tyr Leu Glu Asn Gly Gln Thr Lys Ser Phe Arg Phe Asp Cys Ser Thr 
    210                 215                 220                 


Ser Ile Lys Asp Val Ile Leu Thr Leu Gln Glu Lys Leu Ser Ile Lys 
225                 230                 235                 240 


Gly Ile Glu His Phe Ser Leu Met Leu Glu Gln Arg Thr Glu Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Leu Leu Leu His Glu Gln Glu Thr Leu Thr Gln Val 
            260                 265                 270         


Thr Gln Arg Pro Ser Ser His Lys Met Arg Cys Leu Phe Arg Ile Ser 
        275                 280                 285             


Phe Val Pro Lys Asp Pro Ile Asp Leu Leu Arg Arg Asp Pro Val Ala 
    290                 295                 300                 


Phe Glu Tyr Leu Tyr Val Gln Ser Cys Asn Asp Val Val Gln Glu Arg 
305                 310                 315                 320 


Phe Gly Pro Glu Leu Lys Tyr Asp Ile Ala Leu Arg Leu Ala Ala Leu 
                325                 330                 335     


Gln Met Tyr Ile Ala Thr Val Thr Thr Lys Gln Thr Gln Lys Ile Ser 
            340                 345                 350         


Leu Lys Tyr Ile Glu Lys Glu Trp Gly Leu Glu Thr Phe Leu Pro Ser 
        355                 360                 365             


Ala Val Leu Gln Ser Met Lys Glu Lys Asn Ile Lys Lys Ala Leu Ser 
    370                 375                 380                 


His Leu Val Lys Ala Asn Gln Asn Leu Val Pro Pro Gly Lys Lys Leu 
385                 390                 395                 400 


Ser Ala Leu Gln Ala Lys Val His Tyr Leu Lys Phe Leu Ser Asp Leu 
                405                 410                 415     


Arg Leu Tyr Gly Gly Arg Val Phe Lys Ala Thr Leu Val Gln Ala Glu 
            420                 425                 430         


Lys Arg Ser Glu Val Thr Leu Leu Val Gly Pro Arg Tyr Gly Ile Ser 
        435                 440                 445             


His Val Ile Asn Thr Lys Thr Asn Leu Val Ala Leu Leu Ala Asp Phe 
    450                 455                 460                 


Ser His Val Asn Arg Ile Glu Met Phe Ser Glu Glu Glu Ser Leu Val 
465                 470                 475                 480 


Arg Val Glu Leu His Val Leu Asp Val Lys Pro Ile Thr Leu Leu Met 
                485                 490                 495     


Glu Ser Ser Asp Ala Met Asn Leu Ala Cys Leu Thr Ala Gly Tyr Tyr 
            500                 505                 510         


Arg Leu Leu Val Asp Ser Arg Arg Ser Ile Phe Asn Met Ala Asn Lys 
        515                 520                 525             


Lys Asn Thr Ala Thr Gln Glu Thr Gly Pro Glu Asn Lys Gly Lys His 
    530                 535                 540                 


Asn Leu Leu Gly Pro Asp Trp Asn Cys Ile Pro Gln Met Thr Thr Phe 
545                 550                 555                 560 


Ile Gly Glu Gly Glu Gln Glu Ala Gln Ile Thr Tyr Ile Asp Ser Lys 
                565                 570                 575     


Gln Lys Thr Val Glu Ile Thr Asp Ser Thr Met Cys Pro Lys Glu His 
            580                 585                 590         


Arg His Leu Tyr Ile Asp Asn Ala Tyr Ser Ser Asp Gly Leu Asn Gln 
        595                 600                 605             


Gln Leu Ser Gln Pro Gly Glu Ala Pro Cys Glu Ala Asp Tyr Arg Ser 
    610                 615                 620                 


Leu Ala Gln Arg Ser Leu Leu Thr Leu Ser Gly Pro Glu Thr Leu Lys 
625                 630                 635                 640 


Lys Ala Gln Glu Ser Pro Arg Gly Ala Lys Val Ser Phe Ile Phe Gly 
                645                 650                 655     


Asp Phe Ala Leu Asp Asp Gly Ile Ser Pro Pro Thr Leu Gly Tyr Glu 
            660                 665                 670         


Thr Leu Leu Asp Glu Gly Pro Glu Met Leu Glu Lys Gln Arg Asn Leu 
        675                 680                 685             


Tyr Ile Gly Ser Ala Asn Asp Met Lys Gly Leu Asp Leu Thr Pro Glu 
    690                 695                 700                 


Ala Glu Gly Ile Gln Phe Val Glu Asn Ser Val Tyr Ala Asn Ile Gly 
705                 710                 715                 720 


Asp Val Lys Ser Phe Gln Ala Ala Glu Gly Ile Glu Glu Pro Leu Leu 
                725                 730                 735     


His Asp Ile Cys Tyr Ala Glu Asn Thr Asp Asp Ala Glu Asp Glu Asp 
            740                 745                 750         


Glu Val Ser Cys Glu Glu Asp Leu Val Val Gly Glu Met Asn Gln Pro 
        755                 760                 765             


Ala Ile Leu Asn Leu Ser Gly Ser Ser Asp Asp Ile Ile Asp Leu Thr 
    770                 775                 780                 


Ser Leu Pro Pro Pro Glu Gly Asp Asp Asn Glu Asp Asp Phe Leu Leu 
785                 790                 795                 800 


Arg Ser Leu Asn Met Ala Ile Ala Ala Pro Pro Pro Gly Phe Arg Asp 
                805                 810                 815     


Ser Ser Asp Glu Glu Asp Ser Gln Ser Gln Ala Ala Ser Phe Pro Glu 
            820                 825                 830         


Asp Lys Glu Lys Gly Ser Ser Leu Gln Asn Asp Glu Ile Pro Val Ser 
        835                 840                 845             


Leu Ile Asp Ala Val Pro Thr Ser Ala Glu Gly Lys Cys Glu Lys Gly 
    850                 855                 860                 


Leu Asp Asn Ala Val Val Ser Thr Leu Gly Ala Leu Glu Ala Leu Ser 
865                 870                 875                 880 


Val Ser Glu Glu Gln Gln Thr Ser Asp Asn Ser Gly Val Ala Ile Leu 
                885                 890                 895     


Arg Ala Tyr Ser Pro Glu Ser Ser Ser Asp Ser Gly Asn Glu Thr Asn 
            900                 905                 910         


Ser Ser Glu Met Thr Glu Ser Ser Glu Leu Ala Thr Ala Gln Lys Gln 
        915                 920                 925             


Ser Glu Asn Leu Ser Arg Met Phe Leu Ala Thr His Glu Gly Tyr His 
    930                 935                 940                 


Pro Leu Ala Glu Glu Gln Thr Glu Phe Pro Ala Ser Lys Thr Pro Ala 
945                 950                 955                 960 


Gly Gly Leu Pro Pro Lys Ser Ser His Ala Leu Ala Ala Arg Pro Ala 
                965                 970                 975     


Thr Asp Leu Pro Pro Lys Val Val Pro Ser Lys Gln Leu Leu His Ser 
            980                 985                 990         


Asp His Met Glu Met Glu Pro Glu  Thr Met Glu Thr Lys  Ser Val Thr 
        995                 1000                 1005             


Asp Tyr  Phe Ser Lys Leu His  Met Gly Ser Val Ala  Tyr Ser Cys 
    1010                 1015                 1020             


Thr Ser  Lys Arg Lys Ser Lys  Leu Ala Asp Gly Glu  Gly Lys Ala 
    1025                 1030                 1035             


Pro Pro  Asn Gly Asn Thr Thr  Gly Lys Lys Gln Gln  Gly Thr Lys 
    1040                 1045                 1050             


Thr Ala  Glu Met Glu Glu Glu  Ala Ser Gly Lys Phe  Gly Thr Val 
    1055                 1060                 1065             


Ser Ser  Arg Asp Ser Gln His  Leu Ser Thr Phe Asn  Leu Glu Arg 
    1070                 1075                 1080             


Thr Ala  Phe Arg Lys Asp Ser  Gln Arg Trp Tyr Val  Ala Thr Glu 
    1085                 1090                 1095             


Gly Gly  Met Ala Glu Lys Ser  Gly Leu Glu Ala Ala  Thr Gly Lys 
    1100                 1105                 1110             


Thr Phe  Pro Arg Ala Ser Gly  Leu Gly Ala Arg Glu  Ala Glu Gly 
    1115                 1120                 1125             


Lys Glu  Glu Gly Ala Pro Asp  Gly Glu Thr Ser Asp  Gly Ser Gly 
    1130                 1135                 1140             


Leu Gly  Gln Gly Asp Arg Phe  Leu Thr Asp Val Thr  Cys Ala Ser 
    1145                 1150                 1155             


Ser Ala  Lys Asp Leu Asp Asn  Pro Glu Asp Ala Asp  Ser Ser Thr 
    1160                 1165                 1170             


Cys Asp  His Pro Ser Lys Leu  Pro Glu Ala Asp Glu  Ser Val Ala 
    1175                 1180                 1185             


Arg Leu  Cys Asp Tyr His Leu  Ala Lys Arg Met Ser  Ser Leu Gln 
    1190                 1195                 1200             


Ser Glu  Gly His Phe Ser Leu  Gln Ser Ser Gln Gly  Ser Ser Val 
    1205                 1210                 1215             


Asp Ala  Gly Cys Gly Thr Gly  Ser Ser Gly Ser Ala  Cys Ala Thr 
    1220                 1225                 1230             


Pro Val  Glu Ser Pro Leu Cys  Pro Ser Leu Gly Lys  His Leu Ile 
    1235                 1240                 1245             


Pro Asp  Ala Ser Gly Lys Gly  Val Asn Tyr Ile Pro  Ser Glu Glu 
    1250                 1255                 1260             


Arg Ala  Pro Gly Leu Pro Asn  His Gly Ala Thr Phe  Lys Glu Leu 
    1265                 1270                 1275             


His Pro  Gln Thr Glu Gly Met  Cys Pro Arg Met Thr  Val Pro Ala 
    1280                 1285                 1290             


Leu His  Thr Ala Ile Asn Thr  Glu Pro Leu Phe Gly  Thr Leu Arg 
    1295                 1300                 1305             


Asp Gly  Cys His Arg Leu Pro  Lys Ile Lys Glu Thr  Thr Val 
    1310                 1315                 1320         


<210>  37
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu 
                85                  90                  95      


Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser 
            100                 105                 110         


Val Tyr Gly Gln Cys Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg 
        115                 120                 125             


Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys 
    130                 135                 140                 


Lys Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr 
145                 150                 155                 160 


Asp Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala 
                165                 170                 175     


Lys Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val 
            180                 185                 190         


Thr Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu 
        195                 200                 205             


Tyr Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys 
    210                 215                 220                 


Ser Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser 
225                 230                 235                 240 


Leu Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe 
                245                 250                 255     


Phe Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn 
            260                 265                 270         


Gln Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn 
        275                 280                 285             


Thr Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val 
    290                 295                 300                 


Gln Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro 
305                 310                 315                 320 


Gln Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly 
                325                 330                 335     


Glu Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys 
            340                 345                 350         


Leu Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys 
        355                 360                 365             


Pro Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro 
    370                 375                 380         


<210>  38
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Tyr Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  39
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Asn Val Pro His Lys Ser Ser Leu Pro Glu Gly Ile Arg Pro 
1               5                   10                  15      


Gly Thr Val Leu Arg Ile Arg Gly Leu Val Pro Pro Asn Ala Ser Arg 
            20                  25                  30          


Phe His Val Asn Leu Leu Cys Gly Glu Glu Gln Gly Ser Asp Ala Ala 
        35                  40                  45              


Leu His Phe Asn Pro Arg Leu Asp Thr Ser Glu Val Val Phe Asn Ser 
    50                  55                  60                  


Lys Glu Gln Gly Ser Trp Gly Arg Glu Glu Arg Gly Pro Gly Val Pro 
65                  70                  75                  80  


Phe Gln Arg Gly Gln Pro Phe Glu Val Leu Ile Ile Ala Ser Asp Asp 
                85                  90                  95      


Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His Phe Arg His 
            100                 105                 110         


Arg Leu Pro Leu Ala Arg Val Arg Leu Val Glu Val Gly Gly Asp Val 
        115                 120                 125             


Gln Leu Asp Ser Val Arg Ile Phe 
    130                 135     


<210>  40
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Asn Ser Gly Cys Lys Asp Val Thr Gly Pro Asp Glu Glu Ser 
1               5                   10                  15      


Phe Leu Tyr Phe Ala Tyr Gly Ser Asn Leu Leu Thr Glu Arg Ile His 
            20                  25                  30          


Leu Arg Asn Pro Ser Ala Ala Phe Phe Cys Val Ala Arg Leu Gln Asp 
        35                  40                  45              


Phe Lys Leu Asp Phe Gly Asn Ser Gln Gly Lys Thr Ser Gln Thr Trp 
    50                  55                  60                  


His Gly Gly Ile Ala Thr Ile Phe Gln Ser Pro Gly Asp Glu Val Trp 
65                  70                  75                  80  


Gly Val Val Trp Lys Met Asn Lys Ser Asn Leu Asn Ser Leu Asp Glu 
                85                  90                  95      


Gln Glu Gly Val Lys Ser Gly Met Tyr Val Val Ile Glu Val Lys Val 
            100                 105                 110         


Ala Thr Gln Glu Gly Lys Glu Ile Thr Cys Arg Ser Tyr Leu Met Thr 
        115                 120                 125             


Asn Tyr Glu Ser Ala Pro Pro Ser Pro Gln Tyr Lys Lys Ile Ile Cys 
    130                 135                 140                 


Met Gly Ala Lys Glu Asn Gly Leu Pro Leu Glu Tyr Gln Glu Lys Leu 
145                 150                 155                 160 


Lys Ala Ile Glu Pro Asn Asp Tyr Thr Gly Lys Val Ser Glu Glu Ile 
                165                 170                 175     


Glu Asp Ile Ile Lys Lys Gly Glu Thr Gln Thr Leu 
            180                 185             


<210>  41
<211>  226
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  selenocysteine

<400>  41

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr Xaa Gly Leu Thr Gly Gln Tyr Ile 
65                  70                  75                  80  


Glu Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile 
                85                  90                  95      


Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn 
            100                 105                 110         


Ser Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
        115                 120                 125             


Val Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
    130                 135                 140                 


Glu Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser 
145                 150                 155                 160 


Glu Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val 
                165                 170                 175     


His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
            180                 185                 190         


Ile Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys 
        195                 200                 205             


Met Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys 
    210                 215                 220                 


Arg Lys 
225     


<210>  42
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu Leu Leu Leu Leu Met 
1               5                   10                  15      


Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln Thr Thr Asp Trp Arg 
            20                  25                  30          


Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His Lys Ile Asp Thr Tyr 
        35                  40                  45              


Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly Leu Cys Gln 
    50                  55                  60                  


Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro Arg Tyr Gly Tyr Lys 
65                  70                  75                  80  


Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Val His Leu 
                85                  90                  95      


Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln His Asp Arg 
            100                 105                 110         


Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp Glu Glu Phe 
        115                 120                 125             


Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys Thr Leu Gly 
    130                 135                 140                 


Leu Thr Gln His Val Gln Ala Cys Glu Thr Thr Val Glu Leu Leu Phe 
145                 150                 155                 160 


Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg 
                165                 170                 175     


Ala Ala Cys Arg Cys His Tyr Glu Glu Lys Thr Asp Leu 
            180                 185                 


<210>  43
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      


Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         


Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 
        115                 120                 125             


Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 
    130                 135                 140                 


Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 
145                 150                 155                 160 


Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 
                165                 170                 175     


Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 
            180                 185                 190         


Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 
        195                 200                 205             


Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 
    210                 215                 220                 


Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 
225                 230                 235                 240 


Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 
                245                 250                 255     


Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 
            260                 265                 270         


Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 
        275                 280                 285             


Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 
    290                 295                 300                 


Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 
305                 310                 315                 320 


Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 
                325                 330                 335     


His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 
            340                 345                 350         


Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 
        355                 360                 365             


Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 
    370                 375                 380                 


Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 
385                 390                 395                 400 


Lys Thr Ile Ala Glu Asn 
                405     


<210>  44
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser 
1               5                   10                  15      


Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 
            20                  25                  30          


Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 
        35                  40                  45              


Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 
    50                  55                  60                  


Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val 
65                  70                  75                  80  


Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 
                85                  90                  95      


Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 
            100                 105                 110         


Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 
        115                 120                 125             


Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 
    130                 135                 140                 


Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 
                165                 170                 175     


Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 
            180                 185                 190         


Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 
        195                 200                 205             


Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 
    210                 215                 220                 


Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn 
225                 230                 235                 240 


Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 
                245                 250                 255     


Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 
            260                 265                 270         


Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 
        275                 280                 285             


Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 
    290                 295                 300                 


Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu 
305                 310                 315                 320 


Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 
                325                 330                 335     


Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 
            340                 345                 350         


Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 
        355                 360                 365             


His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 
    370                 375                 380                 


His Pro His Gly His His Pro His Gly His His Pro His Gly His His 
385                 390                 395                 400 


Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 
                405                 410                 415     


Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 
            420                 425                 430         


Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 
        435                 440                 445             


Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 
    450                 455                 460                 


Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe 
465                 470                 475                 480 


Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 
                485                 490                 495     


Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 
            500                 505                 510         


Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 
        515                 520                 525 


<210>  45
<211>  3972
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala His Ser Cys Arg Trp Arg Phe Pro Ala Arg Pro Gly Thr Thr 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Arg Arg Gly Leu Gly Gly Ala Pro Arg 
            20                  25                  30          


Gln Arg Val Pro Ala Leu Leu Leu Pro Pro Gly Pro Pro Val Gly Gly 
        35                  40                  45              


Gly Gly Pro Gly Ala Pro Pro Ser Pro Pro Ala Val Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Gly Ser Ser Gly Ala Gly Val Pro Gly Gly Ala Ala Ala 
65                  70                  75                  80  


Ala Ser Ala Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Ser Ala Ser Ser Gly Pro Ala Leu Leu Arg Val Gly Pro Gly Phe 
            100                 105                 110         


Asp Ala Ala Leu Gln Val Ser Ala Ala Ile Gly Thr Asn Leu Arg Arg 
        115                 120                 125             


Phe Arg Ala Val Phe Gly Glu Ser Gly Gly Gly Gly Gly Ser Gly Glu 
    130                 135                 140                 


Asp Glu Gln Phe Leu Gly Phe Gly Ser Asp Glu Glu Val Arg Val Arg 
145                 150                 155                 160 


Ser Pro Thr Arg Ser Pro Ser Val Lys Thr Ser Pro Arg Lys Pro Arg 
                165                 170                 175     


Gly Arg Pro Arg Ser Gly Ser Asp Arg Asn Ser Ala Ile Leu Ser Asp 
            180                 185                 190         


Pro Ser Val Phe Ser Pro Leu Asn Lys Ser Glu Thr Lys Ser Gly Asp 
        195                 200                 205             


Lys Ile Lys Lys Lys Asp Ser Lys Ser Ile Glu Lys Lys Arg Gly Arg 
    210                 215                 220                 


Pro Pro Thr Phe Pro Gly Val Lys Ile Lys Ile Thr His Gly Lys Asp 
225                 230                 235                 240 


Ile Ser Glu Leu Pro Lys Gly Asn Lys Glu Asp Ser Leu Lys Lys Ile 
                245                 250                 255     


Lys Arg Thr Pro Ser Ala Thr Phe Gln Gln Ala Thr Lys Ile Lys Lys 
            260                 265                 270         


Leu Arg Ala Gly Lys Leu Ser Pro Leu Lys Ser Lys Phe Lys Thr Gly 
        275                 280                 285             


Lys Leu Gln Ile Gly Arg Lys Gly Val Gln Ile Val Arg Arg Arg Gly 
    290                 295                 300                 


Arg Pro Pro Ser Thr Glu Arg Ile Lys Thr Pro Ser Gly Leu Leu Ile 
305                 310                 315                 320 


Asn Ser Glu Leu Glu Lys Pro Gln Lys Val Arg Lys Asp Lys Glu Gly 
                325                 330                 335     


Thr Pro Pro Leu Thr Lys Glu Asp Lys Thr Val Val Arg Gln Ser Pro 
            340                 345                 350         


Arg Arg Ile Lys Pro Val Arg Ile Ile Pro Ser Ser Lys Arg Thr Asp 
        355                 360                 365             


Ala Thr Ile Ala Lys Gln Leu Leu Gln Arg Ala Lys Lys Gly Ala Gln 
    370                 375                 380                 


Lys Lys Ile Glu Lys Glu Ala Ala Gln Leu Gln Gly Arg Lys Val Lys 
385                 390                 395                 400 


Thr Gln Val Lys Asn Ile Arg Gln Phe Ile Met Pro Val Val Ser Ala 
                405                 410                 415     


Ile Ser Ser Arg Ile Ile Lys Thr Pro Arg Arg Phe Ile Glu Asp Glu 
            420                 425                 430         


Asp Tyr Asp Pro Pro Ile Lys Ile Ala Arg Leu Glu Ser Thr Pro Asn 
        435                 440                 445             


Ser Arg Phe Ser Ala Pro Ser Cys Gly Ser Ser Glu Lys Ser Ser Ala 
    450                 455                 460                 


Ala Ser Gln His Ser Ser Gln Met Ser Ser Asp Ser Ser Arg Ser Ser 
465                 470                 475                 480 


Ser Pro Ser Val Asp Thr Ser Thr Asp Ser Gln Ala Ser Glu Glu Ile 
                485                 490                 495     


Gln Val Leu Pro Glu Glu Arg Ser Asp Thr Pro Glu Val His Pro Pro 
            500                 505                 510         


Leu Pro Ile Ser Gln Ser Pro Glu Asn Glu Ser Asn Asp Arg Arg Ser 
        515                 520                 525             


Arg Arg Tyr Ser Val Ser Glu Arg Ser Phe Gly Ser Arg Thr Thr Lys 
    530                 535                 540                 


Lys Leu Ser Thr Leu Gln Ser Ala Pro Gln Gln Gln Thr Ser Ser Ser 
545                 550                 555                 560 


Pro Pro Pro Pro Leu Leu Thr Pro Pro Pro Pro Leu Gln Pro Ala Ser 
                565                 570                 575     


Ser Ile Ser Asp His Thr Pro Trp Leu Met Pro Pro Thr Ile Pro Leu 
            580                 585                 590         


Ala Ser Pro Phe Leu Pro Ala Ser Thr Ala Pro Met Gln Gly Lys Arg 
        595                 600                 605             


Lys Ser Ile Leu Arg Glu Pro Thr Phe Arg Trp Thr Ser Leu Lys His 
    610                 615                 620                 


Ser Arg Ser Glu Pro Gln Tyr Phe Ser Ser Ala Lys Tyr Ala Lys Glu 
625                 630                 635                 640 


Gly Leu Ile Arg Lys Pro Ile Phe Asp Asn Phe Arg Pro Pro Pro Leu 
                645                 650                 655     


Thr Pro Glu Asp Val Gly Phe Ala Ser Gly Phe Ser Ala Ser Gly Thr 
            660                 665                 670         


Ala Ala Ser Ala Arg Leu Phe Ser Pro Leu His Ser Gly Thr Arg Phe 
        675                 680                 685             


Asp Met His Lys Arg Ser Pro Leu Leu Arg Ala Pro Arg Phe Thr Pro 
    690                 695                 700                 


Ser Glu Ala His Ser Arg Ile Phe Glu Ser Val Thr Leu Pro Ser Asn 
705                 710                 715                 720 


Arg Thr Ser Ala Gly Thr Ser Ser Ser Gly Val Ser Asn Arg Lys Arg 
                725                 730                 735     


Lys Arg Lys Val Phe Ser Pro Ile Arg Ser Glu Pro Arg Ser Pro Ser 
            740                 745                 750         


His Ser Met Arg Thr Arg Ser Gly Arg Leu Ser Ser Ser Glu Leu Ser 
        755                 760                 765             


Pro Leu Thr Pro Pro Ser Ser Val Ser Ser Ser Leu Ser Ile Ser Val 
    770                 775                 780                 


Ser Pro Leu Ala Thr Ser Ala Leu Asn Pro Thr Phe Thr Phe Pro Ser 
785                 790                 795                 800 


His Ser Leu Thr Gln Ser Gly Glu Ser Ala Glu Lys Asn Gln Arg Pro 
                805                 810                 815     


Arg Lys Gln Thr Ser Ala Pro Ala Glu Pro Phe Ser Ser Ser Ser Pro 
            820                 825                 830         


Thr Pro Leu Phe Pro Trp Phe Thr Pro Gly Ser Gln Thr Glu Arg Gly 
        835                 840                 845             


Arg Asn Lys Asp Lys Ala Pro Glu Glu Leu Ser Lys Asp Arg Asp Ala 
    850                 855                 860                 


Asp Lys Ser Val Glu Lys Asp Lys Ser Arg Glu Arg Asp Arg Glu Arg 
865                 870                 875                 880 


Glu Lys Glu Asn Lys Arg Glu Ser Arg Lys Glu Lys Arg Lys Lys Gly 
                885                 890                 895     


Ser Glu Ile Gln Ser Ser Ser Ala Leu Tyr Pro Val Gly Arg Val Ser 
            900                 905                 910         


Lys Glu Lys Val Val Gly Glu Asp Val Ala Thr Ser Ser Ser Ala Lys 
        915                 920                 925             


Lys Ala Thr Gly Arg Lys Lys Ser Ser Ser His Asp Ser Gly Thr Asp 
    930                 935                 940                 


Ile Thr Ser Val Thr Leu Gly Asp Thr Thr Ala Val Lys Thr Lys Ile 
945                 950                 955                 960 


Leu Ile Lys Lys Gly Arg Gly Asn Leu Glu Lys Thr Asn Leu Asp Leu 
                965                 970                 975     


Gly Pro Thr Ala Pro Ser Leu Glu Lys Glu Lys Thr Leu Cys Leu Ser 
            980                 985                 990         


Thr Pro Ser Ser Ser Thr Val Lys  His Ser Thr Ser Ser  Ile Gly Ser 
        995                 1000                 1005             


Met Leu  Ala Gln Ala Asp Lys  Leu Pro Met Thr Asp  Lys Arg Val 
    1010                 1015                 1020             


Ala Ser  Leu Leu Lys Lys Ala  Lys Ala Gln Leu Cys  Lys Ile Glu 
    1025                 1030                 1035             


Lys Ser  Lys Ser Leu Lys Gln  Thr Asp Gln Pro Lys  Ala Gln Gly 
    1040                 1045                 1050             


Gln Glu  Ser Asp Ser Ser Glu  Thr Ser Val Arg Gly  Pro Arg Ile 
    1055                 1060                 1065             


Lys His  Val Cys Arg Arg Ala  Ala Val Ala Leu Gly  Arg Lys Arg 
    1070                 1075                 1080             


Ala Val  Phe Pro Asp Asp Met  Pro Thr Leu Ser Ala  Leu Pro Trp 
    1085                 1090                 1095             


Glu Glu  Arg Glu Lys Ile Leu  Ser Ser Met Gly Asn  Asp Asp Lys 
    1100                 1105                 1110             


Ser Ser  Ile Ala Gly Ser Glu  Asp Ala Glu Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Ile Lys  Pro Ile Lys Pro Val  Thr Arg Asn Lys Ala  Pro Gln Glu 
    1130                 1135                 1140             


Pro Pro  Val Lys Lys Gly Arg  Arg Ser Arg Arg Cys  Gly Gln Cys 
    1145                 1150                 1155             


Pro Gly  Cys Gln Val Pro Glu  Asp Cys Gly Val Cys  Thr Asn Cys 
    1160                 1165                 1170             


Leu Asp  Lys Pro Lys Phe Gly  Gly Arg Asn Ile Lys  Lys Gln Cys 
    1175                 1180                 1185             


Cys Lys  Met Arg Lys Cys Gln  Asn Leu Gln Trp Met  Pro Ser Lys 
    1190                 1195                 1200             


Ala Tyr  Leu Gln Lys Gln Ala  Lys Ala Val Lys Lys  Lys Glu Lys 
    1205                 1210                 1215             


Lys Ser  Lys Thr Ser Glu Lys  Lys Asp Ser Lys Glu  Ser Ser Val 
    1220                 1225                 1230             


Val Lys  Asn Val Val Asp Ser  Ser Gln Lys Pro Thr  Pro Ser Ala 
    1235                 1240                 1245             


Arg Glu  Asp Pro Ala Pro Lys  Lys Ser Ser Ser Glu  Pro Pro Pro 
    1250                 1255                 1260             


Arg Lys  Pro Val Glu Glu Lys  Ser Glu Glu Gly Asn  Val Ser Ala 
    1265                 1270                 1275             


Pro Gly  Pro Glu Ser Lys Gln  Ala Thr Thr Pro Ala  Ser Arg Lys 
    1280                 1285                 1290             


Ser Ser  Lys Gln Val Ser Gln  Pro Ala Leu Val Ile  Pro Pro Gln 
    1295                 1300                 1305             


Pro Pro  Thr Thr Gly Pro Pro  Arg Lys Glu Val Pro  Lys Thr Thr 
    1310                 1315                 1320             


Pro Ser  Glu Pro Lys Lys Lys  Gln Pro Pro Pro Pro  Glu Ser Gly 
    1325                 1330                 1335             


Pro Glu  Gln Ser Lys Gln Lys  Lys Val Ala Pro Arg  Pro Ser Ile 
    1340                 1345                 1350             


Pro Val  Lys Gln Lys Pro Lys  Glu Lys Glu Lys Pro  Pro Pro Val 
    1355                 1360                 1365             


Asn Lys  Gln Glu Asn Ala Gly  Thr Leu Asn Ile Leu  Ser Thr Leu 
    1370                 1375                 1380             


Ser Asn  Gly Asn Ser Ser Lys  Gln Lys Ile Pro Ala  Asp Gly Val 
    1385                 1390                 1395             


His Arg  Ile Arg Val Asp Phe  Lys Glu Asp Cys Glu  Ala Glu Asn 
    1400                 1405                 1410             


Val Trp  Glu Met Gly Gly Leu  Gly Ile Leu Thr Ser  Val Pro Ile 
    1415                 1420                 1425             


Thr Pro  Arg Val Val Cys Phe  Leu Cys Ala Ser Ser  Gly His Val 
    1430                 1435                 1440             


Glu Phe  Val Tyr Cys Gln Val  Cys Cys Glu Pro Phe  His Lys Phe 
    1445                 1450                 1455             


Cys Leu  Glu Glu Asn Glu Arg  Pro Leu Glu Asp Gln  Leu Glu Asn 
    1460                 1465                 1470             


Trp Cys  Cys Arg Arg Cys Lys  Phe Cys His Val Cys  Gly Arg Gln 
    1475                 1480                 1485             


His Gln  Ala Thr Lys Gln Leu  Leu Glu Cys Asn Lys  Cys Arg Asn 
    1490                 1495                 1500             


Ser Tyr  His Pro Glu Cys Leu  Gly Pro Asn Tyr Pro  Thr Lys Pro 
    1505                 1510                 1515             


Thr Lys  Lys Lys Lys Val Trp  Ile Cys Thr Lys Cys  Val Arg Cys 
    1520                 1525                 1530             


Lys Ser  Cys Gly Ser Thr Thr  Pro Gly Lys Gly Trp  Asp Ala Gln 
    1535                 1540                 1545             


Trp Ser  His Asp Phe Ser Leu  Cys His Asp Cys Ala  Lys Leu Phe 
    1550                 1555                 1560             


Ala Lys  Gly Asn Phe Cys Pro  Leu Cys Asp Lys Cys  Tyr Asp Asp 
    1565                 1570                 1575             


Asp Asp  Tyr Glu Ser Lys Met  Met Gln Cys Gly Lys  Cys Asp Arg 
    1580                 1585                 1590             


Trp Val  His Ser Lys Cys Glu  Asn Leu Ser Gly Thr  Glu Asp Glu 
    1595                 1600                 1605             


Met Tyr  Glu Ile Leu Ser Asn  Leu Pro Glu Ser Val  Ala Tyr Thr 
    1610                 1615                 1620             


Cys Val  Asn Cys Thr Glu Arg  His Pro Ala Glu Trp  Arg Leu Ala 
    1625                 1630                 1635             


Leu Glu  Lys Glu Leu Gln Ile  Ser Leu Lys Gln Val  Leu Thr Ala 
    1640                 1645                 1650             


Leu Leu  Asn Ser Arg Thr Thr  Ser His Leu Leu Arg  Tyr Arg Gln 
    1655                 1660                 1665             


Ala Ala  Lys Pro Pro Asp Leu  Asn Pro Glu Thr Glu  Glu Ser Ile 
    1670                 1675                 1680             


Pro Ser  Arg Ser Ser Pro Glu  Gly Pro Asp Pro Pro  Val Leu Thr 
    1685                 1690                 1695             


Glu Val  Ser Lys Gln Asp Asp  Gln Gln Pro Leu Asp  Leu Glu Gly 
    1700                 1705                 1710             


Val Lys  Arg Lys Met Asp Gln  Gly Asn Tyr Thr Ser  Val Leu Glu 
    1715                 1720                 1725             


Phe Ser  Asp Asp Ile Val Lys  Ile Ile Gln Ala Ala  Ile Asn Ser 
    1730                 1735                 1740             


Asp Gly  Gly Gln Pro Glu Ile  Lys Lys Ala Asn Ser  Met Val Lys 
    1745                 1750                 1755             


Ser Phe  Phe Ile Arg Gln Met  Glu Arg Val Phe Pro  Trp Phe Ser 
    1760                 1765                 1770             


Val Lys  Lys Ser Arg Phe Trp  Glu Pro Asn Lys Val  Ser Ser Asn 
    1775                 1780                 1785             


Ser Gly  Met Leu Pro Asn Ala  Val Leu Pro Pro Ser  Leu Asp His 
    1790                 1795                 1800             


Asn Tyr  Ala Gln Trp Gln Glu  Arg Glu Glu Asn Ser  His Thr Glu 
    1805                 1810                 1815             


Gln Pro  Pro Leu Met Lys Lys  Ile Ile Pro Ala Pro  Lys Pro Lys 
    1820                 1825                 1830             


Gly Pro  Gly Glu Pro Asp Ser  Pro Thr Pro Leu His  Pro Pro Thr 
    1835                 1840                 1845             


Pro Pro  Ile Leu Ser Thr Asp  Arg Ser Arg Glu Asp  Ser Pro Glu 
    1850                 1855                 1860             


Leu Asn  Pro Pro Pro Gly Ile  Glu Asp Asn Arg Gln  Cys Ala Leu 
    1865                 1870                 1875             


Cys Leu  Thr Tyr Gly Asp Asp  Ser Ala Asn Asp Ala  Gly Arg Leu 
    1880                 1885                 1890             


Leu Tyr  Ile Gly Gln Asn Glu  Trp Thr His Val Asn  Cys Ala Leu 
    1895                 1900                 1905             


Trp Ser  Ala Glu Val Phe Glu  Asp Asp Asp Gly Ser  Leu Lys Asn 
    1910                 1915                 1920             


Val His  Met Ala Val Ile Arg  Gly Lys Gln Leu Arg  Cys Glu Phe 
    1925                 1930                 1935             


Cys Gln  Lys Pro Gly Ala Thr  Val Gly Cys Cys Leu  Thr Ser Cys 
    1940                 1945                 1950             


Thr Ser  Asn Tyr His Phe Met  Cys Ser Arg Ala Lys  Asn Cys Val 
    1955                 1960                 1965             


Phe Leu  Asp Asp Lys Lys Val  Tyr Cys Gln Arg His  Arg Asp Leu 
    1970                 1975                 1980             


Ile Lys  Gly Glu Val Val Pro  Glu Asn Gly Phe Glu  Val Phe Arg 
    1985                 1990                 1995             


Arg Val  Phe Val Asp Phe Glu  Gly Ile Ser Leu Arg  Arg Lys Phe 
    2000                 2005                 2010             


Leu Asn  Gly Leu Glu Pro Glu  Asn Ile His Met Met  Ile Gly Ser 
    2015                 2020                 2025             


Met Thr  Ile Asp Cys Leu Gly  Ile Leu Asn Asp Leu  Ser Asp Cys 
    2030                 2035                 2040             


Glu Asp  Lys Leu Phe Pro Ile  Gly Tyr Gln Cys Ser  Arg Val Tyr 
    2045                 2050                 2055             


Trp Ser  Thr Thr Asp Ala Arg  Lys Arg Cys Val Tyr  Thr Cys Lys 
    2060                 2065                 2070             


Ile Val  Glu Cys Arg Pro Pro  Val Val Glu Pro Asp  Ile Asn Ser 
    2075                 2080                 2085             


Thr Val  Glu His Asp Glu Asn  Arg Thr Ile Ala His  Ser Pro Thr 
    2090                 2095                 2100             


Ser Phe  Thr Glu Ser Ser Ser  Lys Glu Ser Gln Asn  Thr Ala Glu 
    2105                 2110                 2115             


Ile Ile  Ser Pro Pro Ser Pro  Asp Arg Pro Pro His  Ser Gln Thr 
    2120                 2125                 2130             


Ser Gly  Ser Cys Tyr Tyr His  Val Ile Ser Lys Val  Pro Arg Ile 
    2135                 2140                 2145             


Arg Thr  Pro Ser Tyr Ser Pro  Thr Gln Arg Ser Pro  Gly Cys Arg 
    2150                 2155                 2160             


Pro Leu  Pro Ser Ala Gly Ser  Pro Thr Pro Thr Thr  His Glu Ile 
    2165                 2170                 2175             


Val Thr  Val Gly Asp Pro Leu  Leu Ser Ser Gly Leu  Arg Ser Ile 
    2180                 2185                 2190             


Gly Ser  Arg Arg His Ser Thr  Ser Ser Leu Ser Pro  Gln Arg Ser 
    2195                 2200                 2205             


Lys Leu  Arg Ile Met Ser Pro  Met Arg Thr Gly Asn  Thr Tyr Ser 
    2210                 2215                 2220             


Arg Asn  Asn Val Ser Ser Val  Ser Thr Thr Gly Thr  Ala Thr Asp 
    2225                 2230                 2235             


Leu Glu  Ser Ser Ala Lys Val  Val Asp His Val Leu  Gly Pro Leu 
    2240                 2245                 2250             


Asn Ser  Ser Thr Ser Leu Gly  Gln Asn Thr Ser Thr  Ser Ser Asn 
    2255                 2260                 2265             


Leu Gln  Arg Thr Val Val Thr  Val Gly Asn Lys Asn  Ser His Leu 
    2270                 2275                 2280             


Asp Gly  Ser Ser Ser Ser Glu  Met Lys Gln Ser Ser  Ala Ser Asp 
    2285                 2290                 2295             


Leu Val  Ser Lys Ser Ser Ser  Leu Lys Gly Glu Lys  Thr Lys Val 
    2300                 2305                 2310             


Leu Ser  Ser Lys Ser Ser Glu  Gly Ser Ala His Asn  Val Ala Tyr 
    2315                 2320                 2325             


Pro Gly  Ile Pro Lys Leu Ala  Pro Gln Val His Asn  Thr Thr Ser 
    2330                 2335                 2340             


Arg Glu  Leu Asn Val Ser Lys  Ile Gly Ser Phe Ala  Glu Pro Ser 
    2345                 2350                 2355             


Ser Val  Ser Phe Ser Ser Lys  Glu Ala Leu Ser Phe  Pro His Leu 
    2360                 2365                 2370             


His Leu  Arg Gly Gln Arg Asn  Asp Arg Asp Gln His  Thr Asp Ser 
    2375                 2380                 2385             


Thr Gln  Ser Ala Asn Ser Ser  Pro Asp Glu Asp Thr  Glu Val Lys 
    2390                 2395                 2400             


Thr Leu  Lys Leu Ser Gly Met  Ser Asn Arg Ser Ser  Ile Ile Asn 
    2405                 2410                 2415             


Glu His  Met Gly Ser Ser Ser  Arg Asp Arg Arg Gln  Lys Gly Lys 
    2420                 2425                 2430             


Lys Ser  Cys Lys Glu Thr Phe  Lys Glu Lys His Ser  Ser Lys Ser 
    2435                 2440                 2445             


Phe Leu  Glu Pro Gly Gln Val  Thr Thr Gly Glu Glu  Gly Asn Leu 
    2450                 2455                 2460             


Lys Pro  Glu Phe Met Asp Glu  Val Leu Thr Pro Glu  Tyr Met Gly 
    2465                 2470                 2475             


Gln Arg  Pro Cys Asn Asn Val  Ser Ser Asp Lys Ile  Gly Asp Lys 
    2480                 2485                 2490             


Gly Leu  Ser Met Pro Gly Val  Pro Lys Ala Pro Pro  Met Gln Val 
    2495                 2500                 2505             


Glu Gly  Ser Ala Lys Glu Leu  Gln Ala Pro Arg Lys  Arg Thr Val 
    2510                 2515                 2520             


Lys Val  Thr Leu Thr Pro Leu  Lys Met Glu Asn Glu  Ser Gln Ser 
    2525                 2530                 2535             


Lys Asn  Ala Leu Lys Glu Ser  Ser Pro Ala Ser Pro  Leu Gln Ile 
    2540                 2545                 2550             


Glu Ser  Thr Ser Pro Thr Glu  Pro Ile Ser Ala Ser  Glu Asn Pro 
    2555                 2560                 2565             


Gly Asp  Gly Pro Val Ala Gln  Pro Ser Pro Asn Asn  Thr Ser Cys 
    2570                 2575                 2580             


Gln Asp  Ser Gln Ser Asn Asn  Tyr Gln Asn Leu Pro  Val Gln Asp 
    2585                 2590                 2595             


Arg Asn  Leu Met Leu Pro Asp  Gly Pro Lys Pro Gln  Glu Asp Gly 
    2600                 2605                 2610             


Ser Phe  Lys Arg Arg Tyr Pro  Arg Arg Ser Ala Arg  Ala Arg Ser 
    2615                 2620                 2625             


Asn Met  Phe Phe Gly Leu Thr  Pro Leu Tyr Gly Val  Arg Ser Tyr 
    2630                 2635                 2640             


Gly Glu  Glu Asp Ile Pro Phe  Tyr Ser Ser Ser Thr  Gly Lys Lys 
    2645                 2650                 2655             


Arg Gly  Lys Arg Ser Ala Glu  Gly Gln Val Asp Gly  Ala Asp Asp 
    2660                 2665                 2670             


Leu Ser  Thr Ser Asp Glu Asp  Asp Leu Tyr Tyr Tyr  Asn Phe Thr 
    2675                 2680                 2685             


Arg Thr  Val Ile Ser Ser Gly  Gly Glu Glu Arg Leu  Ala Ser His 
    2690                 2695                 2700             


Asn Leu  Phe Arg Glu Glu Glu  Gln Cys Asp Leu Pro  Lys Ile Ser 
    2705                 2710                 2715             


Gln Leu  Asp Gly Val Asp Asp  Gly Thr Glu Ser Asp  Thr Ser Val 
    2720                 2725                 2730             


Thr Ala  Thr Thr Arg Lys Ser  Ser Gln Ile Pro Lys  Arg Asn Gly 
    2735                 2740                 2745             


Lys Glu  Asn Gly Thr Glu Asn  Leu Lys Ile Asp Arg  Pro Glu Asp 
    2750                 2755                 2760             


Ala Gly  Glu Lys Glu His Val  Thr Lys Ser Ser Val  Gly His Lys 
    2765                 2770                 2775             


Asn Glu  Pro Lys Met Asp Asn  Cys His Ser Val Ser  Arg Val Lys 
    2780                 2785                 2790             


Thr Gln  Gly Gln Asp Ser Leu  Glu Ala Gln Leu Ser  Ser Leu Glu 
    2795                 2800                 2805             


Ser Ser  Arg Arg Val His Thr  Ser Thr Pro Ser Asp  Lys Asn Leu 
    2810                 2815                 2820             


Leu Asp  Thr Tyr Asn Thr Glu  Leu Leu Lys Ser Asp  Ser Asp Asn 
    2825                 2830                 2835             


Asn Asn  Ser Asp Asp Cys Gly  Asn Ile Leu Pro Ser  Asp Ile Met 
    2840                 2845                 2850             


Asp Phe  Val Leu Lys Asn Thr  Pro Ser Met Gln Ala  Leu Gly Glu 
    2855                 2860                 2865             


Ser Pro  Glu Ser Ser Ser Ser  Glu Leu Leu Asn Leu  Gly Glu Gly 
    2870                 2875                 2880             


Leu Gly  Leu Asp Ser Asn Arg  Glu Lys Asp Met Gly  Leu Phe Glu 
    2885                 2890                 2895             


Val Phe  Ser Gln Gln Leu Pro  Thr Thr Glu Pro Val  Asp Ser Ser 
    2900                 2905                 2910             


Val Ser  Ser Ser Ile Ser Ala  Glu Glu Gln Phe Glu  Leu Pro Leu 
    2915                 2920                 2925             


Glu Leu  Pro Ser Asp Leu Ser  Val Leu Thr Thr Arg  Ser Pro Thr 
    2930                 2935                 2940             


Val Pro  Ser Gln Asn Pro Ser  Arg Leu Ala Val Ile  Ser Asp Ser 
    2945                 2950                 2955             


Gly Glu  Lys Arg Val Thr Ile  Thr Glu Lys Ser Val  Ala Ser Ser 
    2960                 2965                 2970             


Glu Ser  Asp Pro Ala Leu Leu  Ser Pro Gly Val Asp  Pro Thr Pro 
    2975                 2980                 2985             


Glu Gly  His Met Thr Pro Asp  His Phe Ile Gln Gly  His Met Asp 
    2990                 2995                 3000             


Ala Asp  His Ile Ser Ser Pro  Pro Cys Gly Ser Val  Glu Gln Gly 
    3005                 3010                 3015             


His Gly  Asn Asn Gln Asp Leu  Thr Arg Asn Ser Ser  Thr Pro Gly 
    3020                 3025                 3030             


Leu Gln  Val Pro Val Ser Pro  Thr Val Pro Ile Gln  Asn Gln Lys 
    3035                 3040                 3045             


Tyr Val  Pro Asn Ser Thr Asp  Ser Pro Gly Pro Ser  Gln Ile Ser 
    3050                 3055                 3060             


Asn Ala  Ala Val Gln Thr Thr  Pro Pro His Leu Lys  Pro Ala Thr 
    3065                 3070                 3075             


Glu Lys  Leu Ile Val Val Asn  Gln Asn Met Gln Pro  Leu Tyr Val 
    3080                 3085                 3090             


Leu Gln  Thr Leu Pro Asn Gly  Val Thr Gln Lys Ile  Gln Leu Thr 
    3095                 3100                 3105             


Ser Ser  Val Ser Ser Thr Pro  Ser Val Met Glu Thr  Asn Thr Ser 
    3110                 3115                 3120             


Val Leu  Gly Pro Met Gly Gly  Gly Leu Thr Leu Thr  Thr Gly Leu 
    3125                 3130                 3135             


Asn Pro  Ser Leu Pro Thr Ser  Gln Ser Leu Phe Pro  Ser Ala Ser 
    3140                 3145                 3150             


Lys Gly  Leu Leu Pro Met Ser  His His Gln His Leu  His Ser Phe 
    3155                 3160                 3165             


Pro Ala  Ala Thr Gln Ser Ser  Phe Pro Pro Asn Ile  Ser Asn Pro 
    3170                 3175                 3180             


Pro Ser  Gly Leu Leu Ile Gly  Val Gln Pro Pro Pro  Asp Pro Gln 
    3185                 3190                 3195             


Leu Leu  Val Ser Glu Ser Ser  Gln Arg Thr Asp Leu  Ser Thr Thr 
    3200                 3205                 3210             


Val Ala  Thr Pro Ser Ser Gly  Leu Lys Lys Arg Pro  Ile Ser Arg 
    3215                 3220                 3225             


Leu Gln  Thr Arg Lys Asn Lys  Lys Leu Ala Pro Ser  Ser Thr Pro 
    3230                 3235                 3240             


Ser Asn  Ile Ala Pro Ser Asp  Val Val Ser Asn Met  Thr Leu Ile 
    3245                 3250                 3255             


Asn Phe  Thr Pro Ser Gln Leu  Pro Asn His Pro Ser  Leu Leu Asp 
    3260                 3265                 3270             


Leu Gly  Ser Leu Asn Thr Ser  Ser His Arg Thr Val  Pro Asn Ile 
    3275                 3280                 3285             


Ile Lys  Arg Ser Lys Ser Ser  Ile Met Tyr Phe Glu  Pro Ala Pro 
    3290                 3295                 3300             


Leu Leu  Pro Gln Ser Val Gly  Gly Thr Ala Ala Thr  Ala Ala Gly 
    3305                 3310                 3315             


Thr Ser  Thr Ile Ser Gln Asp  Thr Ser His Leu Thr  Ser Gly Ser 
    3320                 3325                 3330             


Val Ser  Gly Leu Ala Ser Ser  Ser Ser Val Leu Asn  Val Val Ser 
    3335                 3340                 3345             


Met Gln  Thr Thr Thr Thr Pro  Thr Ser Ser Ala Ser  Val Pro Gly 
    3350                 3355                 3360             


His Val  Thr Leu Thr Asn Pro  Arg Leu Leu Gly Thr  Pro Asp Ile 
    3365                 3370                 3375             


Gly Ser  Ile Ser Asn Leu Leu  Ile Lys Ala Ser Gln  Gln Ser Leu 
    3380                 3385                 3390             


Gly Ile  Gln Asp Gln Pro Val  Ala Leu Pro Pro Ser  Ser Gly Met 
    3395                 3400                 3405             


Phe Pro  Gln Leu Gly Thr Ser  Gln Thr Pro Ser Thr  Ala Ala Ile 
    3410                 3415                 3420             


Thr Ala  Ala Ser Ser Ile Cys  Val Leu Pro Ser Thr  Gln Thr Thr 
    3425                 3430                 3435             


Gly Ile  Thr Ala Ala Ser Pro  Ser Gly Glu Ala Asp  Glu His Tyr 
    3440                 3445                 3450             


Gln Leu  Gln His Val Asn Gln  Leu Leu Ala Ser Lys  Thr Gly Ile 
    3455                 3460                 3465             


His Ser  Ser Gln Arg Asp Leu  Asp Ser Ala Ser Gly  Pro Gln Val 
    3470                 3475                 3480             


Ser Asn  Phe Thr Gln Thr Val  Asp Ala Pro Asn Ser  Met Gly Leu 
    3485                 3490                 3495             


Glu Gln  Asn Lys Ala Leu Ser  Ser Ala Val Gln Ala  Ser Pro Thr 
    3500                 3505                 3510             


Ser Pro  Gly Gly Ser Pro Ser  Ser Pro Ser Ser Gly  Gln Arg Ser 
    3515                 3520                 3525             


Ala Ser  Pro Ser Val Pro Gly  Pro Thr Lys Pro Lys  Pro Lys Thr 
    3530                 3535                 3540             


Lys Arg  Phe Gln Leu Pro Leu  Asp Lys Gly Asn Gly  Lys Lys His 
    3545                 3550                 3555             


Lys Val  Ser His Leu Arg Thr  Ser Ser Ser Glu Ala  His Ile Pro 
    3560                 3565                 3570             


Asp Gln  Glu Thr Thr Ser Leu  Thr Ser Gly Thr Gly  Thr Pro Gly 
    3575                 3580                 3585             


Ala Glu  Ala Glu Gln Gln Asp  Thr Ala Ser Val Glu  Gln Ser Ser 
    3590                 3595                 3600             


Gln Lys  Glu Cys Gly Gln Pro  Ala Gly Gln Val Ala  Val Leu Pro 
    3605                 3610                 3615             


Glu Val  Gln Val Thr Gln Asn  Pro Ala Asn Glu Gln  Glu Ser Ala 
    3620                 3625                 3630             


Glu Pro  Lys Thr Val Glu Glu  Glu Glu Ser Asn Phe  Ser Ser Pro 
    3635                 3640                 3645             


Leu Met  Leu Trp Leu Gln Gln  Glu Gln Lys Arg Lys  Glu Ser Ile 
    3650                 3655                 3660             


Thr Glu  Lys Lys Pro Lys Lys  Gly Leu Val Phe Glu  Ile Ser Ser 
    3665                 3670                 3675             


Asp Asp  Gly Phe Gln Ile Cys  Ala Glu Ser Ile Glu  Asp Ala Trp 
    3680                 3685                 3690             


Lys Ser  Leu Thr Asp Lys Val  Gln Glu Ala Arg Ser  Asn Ala Arg 
    3695                 3700                 3705             


Leu Lys  Gln Leu Ser Phe Ala  Gly Val Asn Gly Leu  Arg Met Leu 
    3710                 3715                 3720             


Gly Ile  Leu His Asp Ala Val  Val Phe Leu Ile Glu  Gln Leu Ser 
    3725                 3730                 3735             


Gly Ala  Lys His Cys Arg Asn  Tyr Lys Phe Arg Phe  His Lys Pro 
    3740                 3745                 3750             


Glu Glu  Ala Asn Glu Pro Pro  Leu Asn Pro His Gly  Ser Ala Arg 
    3755                 3760                 3765             


Ala Glu  Val His Leu Arg Lys  Ser Ala Phe Asp Met  Phe Asn Phe 
    3770                 3775                 3780             


Leu Ala  Ser Lys His Arg Gln  Pro Pro Glu Tyr Asn  Pro Asn Asp 
    3785                 3790                 3795             


Glu Glu  Glu Glu Glu Val Gln  Leu Lys Ser Ala Arg  Arg Ala Thr 
    3800                 3805                 3810             


Ser Met  Asp Leu Pro Met Pro  Met Arg Phe Arg His  Leu Lys Lys 
    3815                 3820                 3825             


Thr Ser  Lys Glu Ala Val Gly  Val Tyr Arg Ser Pro  Ile His Gly 
    3830                 3835                 3840             


Arg Gly  Leu Phe Cys Lys Arg  Asn Ile Asp Ala Gly  Glu Met Val 
    3845                 3850                 3855             


Ile Glu  Tyr Ala Gly Asn Val  Ile Arg Ser Ile Gln  Thr Asp Lys 
    3860                 3865                 3870             


Arg Glu  Lys Tyr Tyr Asp Ser  Lys Gly Ile Gly Cys  Tyr Met Phe 
    3875                 3880                 3885             


Arg Ile  Asp Asp Ser Glu Val  Val Asp Ala Thr Met  His Gly Asn 
    3890                 3895                 3900             


Ala Ala  Arg Phe Ile Asn His  Ser Cys Glu Pro Asn  Cys Tyr Ser 
    3905                 3910                 3915             


Arg Val  Ile Asn Ile Asp Gly  Gln Lys His Ile Val  Ile Phe Ala 
    3920                 3925                 3930             


Met Arg  Lys Ile Tyr Arg Gly  Glu Glu Leu Thr Tyr  Asp Tyr Lys 
    3935                 3940                 3945             


Phe Pro  Ile Glu Asp Ala Ser  Asn Lys Leu Pro Cys  Asn Cys Gly 
    3950                 3955                 3960             


Ala Lys  Lys Cys Arg Lys Phe  Leu Asn 
    3965                 3970         


<210>  46
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
        35                  40                  45              


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn 
    130                 135                 140                 


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala 
145                 150                 155                 160 


Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 
                165                 170                 175     


Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
            340                 345                 350         


Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 
                405                 410                 415     


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly 
465                 470                 475                 480 


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala 
625                 630                 635             


<210>  47
<211>  3333
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr 
    530                 535                 540                 


Gln Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly 
545                 550                 555                 560 


Val Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe 
                565                 570                 575     


Pro His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile 
            580                 585                 590         


Asn Ser Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro 
        595                 600                 605             


Thr Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn 
    610                 615                 620                 


Pro Ser Gly Cys Ser Glu Cys Lys Cys His Lys Ala Gly Thr Val Ser 
625                 630                 635                 640 


Gly Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser 
                645                 650                 655     


His Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala 
            660                 665                 670         


Leu Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile 
        675                 680                 685             


Gly Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln 
    690                 695                 700                 


Cys Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly 
                725                 730                 735     


Ser Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala 
            740                 745                 750         


Phe Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Thr Ser Val Gln 
        755                 760                 765             


Asn Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu 
    770                 775                 780                 


Phe Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser 
785                 790                 795                 800 


Gly His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu 
                805                 810                 815     


Ile Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Val Pro Gly 
            820                 825                 830         


Asn Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Ile Trp Val Ala 
        835                 840                 845             


Cys Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro 
    850                 855                 860                 


Arg Asp Tyr Tyr Glu Ala Ser Val Leu Gln Leu Pro Val Thr Glu Pro 
865                 870                 875                 880 


Cys Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His 
                885                 890                 895     


Leu Pro Val Thr Arg Phe Pro Cys Thr Leu Ala Cys Glu Ala Arg His 
            900                 905                 910         


Phe Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr 
        915                 920                 925             


Pro Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu 
    930                 935                 940                 


His Leu Arg Leu Arg Ile Pro Gln Val Gly His Tyr Val Val Val Val 
945                 950                 955                 960 


Glu Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Val Asn Val 
                965                 970                 975     


Lys Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys 
            980                 985                 990         


Asn Tyr Ser Val Leu Cys Arg Ser  Ala Val Ile Asp His  Met Ser Arg 
        995                 1000                 1005             


Ile Ala  Met Tyr Glu Leu Leu  Ala Asp Ala Asp Ile  Gln Leu Lys 
    1010                 1015                 1020             


Gly His  Met Ala Arg Phe Leu  Leu His Gln Val Cys  Ile Ile Pro 
    1025                 1030                 1035             


Ile Glu  Glu Phe Ser Ala Glu  Tyr Val Arg Pro Gln  Val His Cys 
    1040                 1045                 1050             


Ile Ala  Ser Tyr Gly Arg Phe  Val Asn Gln Ser Ala  Thr Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala His Glu Thr Pro  Pro Thr Ala Leu Ile  Leu Asp Val 
    1070                 1075                 1080             


Leu Ser  Gly Arg Pro Phe Pro  His Leu Pro Gln Gln  Ser Ser Pro 
    1085                 1090                 1095             


Ser Val  Asp Val Leu Pro Gly  Val Thr Leu Lys Ala  Pro Gln Asn 
    1100                 1105                 1110             


Gln Val  Thr Leu Arg Gly Arg  Val Pro His Leu Gly  Arg Tyr Val 
    1115                 1120                 1125             


Phe Val  Ile His Phe Tyr Gln  Ala Ala His Pro Thr  Phe Pro Ala 
    1130                 1135                 1140             


Gln Val  Ser Val Asp Gly Gly  Trp Pro Arg Ala Gly  Ser Phe His 
    1145                 1150                 1155             


Ala Ser  Phe Cys Pro His Val  Leu Gly Cys Arg Asp  Gln Val Ile 
    1160                 1165                 1170             


Ala Glu  Gly Gln Ile Glu Phe  Asp Ile Ser Glu Pro  Glu Val Ala 
    1175                 1180                 1185             


Ala Thr  Val Lys Val Pro Glu  Gly Lys Ser Leu Val  Leu Val Arg 
    1190                 1195                 1200             


Val Leu  Val Val Pro Ala Glu  Asn Tyr Asp Tyr Gln  Ile Leu His 
    1205                 1210                 1215             


Lys Lys  Ser Met Asp Lys Ser  Leu Glu Phe Ile Thr  Asn Cys Gly 
    1220                 1225                 1230             


Lys Asn  Ser Phe Tyr Leu Asp  Pro Gln Thr Ala Ser  Arg Phe Cys 
    1235                 1240                 1245             


Lys Asn  Ser Ala Arg Ser Leu  Val Ala Phe Tyr His  Lys Gly Ala 
    1250                 1255                 1260             


Leu Pro  Cys Glu Cys His Pro  Thr Gly Ala Thr Gly  Pro His Cys 
    1265                 1270                 1275             


Ser Pro  Glu Gly Gly Gln Cys  Pro Cys Gln Pro Asn  Val Ile Gly 
    1280                 1285                 1290             


Arg Gln  Cys Thr Arg Cys Ala  Thr Gly His Tyr Gly  Phe Pro Arg 
    1295                 1300                 1305             


Cys Lys  Pro Cys Ser Cys Gly  Arg Arg Leu Cys Glu  Glu Met Thr 
    1310                 1315                 1320             


Gly Gln  Cys Arg Cys Pro Pro  Arg Thr Val Arg Pro  Gln Cys Glu 
    1325                 1330                 1335             


Val Cys  Glu Thr His Ser Phe  Ser Phe His Pro Met  Ala Gly Cys 
    1340                 1345                 1350             


Glu Gly  Cys Asn Cys Ser Arg  Arg Gly Thr Ile Glu  Ala Ala Met 
    1355                 1360                 1365             


Pro Glu  Cys Asp Arg Asp Ser  Gly Gln Cys Arg Cys  Lys Pro Arg 
    1370                 1375                 1380             


Ile Thr  Gly Arg Gln Cys Asp  Arg Cys Ala Ser Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Phe Pro  Glu Cys Val Pro Cys  Asn Cys Asn Arg Asp  Gly Thr Glu 
    1400                 1405                 1410             


Pro Gly  Val Cys Asp Pro Gly  Thr Gly Ala Cys Leu  Cys Lys Glu 
    1415                 1420                 1425             


Asn Val  Glu Gly Thr Glu Cys  Asn Val Cys Arg Glu  Gly Ser Phe 
    1430                 1435                 1440             


His Leu  Asp Pro Ala Asn Leu  Lys Gly Cys Thr Ser  Cys Phe Cys 
    1445                 1450                 1455             


Phe Gly  Val Asn Asn Gln Cys  His Ser Ser His Lys  Arg Arg Thr 
    1460                 1465                 1470             


Lys Phe  Val Asp Met Leu Gly  Trp His Leu Glu Thr  Ala Asp Arg 
    1475                 1480                 1485             


Val Asp  Ile Pro Val Ser Phe  Asn Pro Gly Ser Asn  Ser Met Val 
    1490                 1495                 1500             


Ala Asp  Leu Gln Glu Leu Pro  Ala Thr Ile His Ser  Ala Ser Trp 
    1505                 1510                 1515             


Val Ala  Pro Thr Ser Tyr Leu  Gly Asp Lys Val Ser  Ser Tyr Gly 
    1520                 1525                 1530             


Gly Tyr  Leu Thr Tyr Gln Ala  Lys Ser Phe Gly Leu  Pro Gly Asp 
    1535                 1540                 1545             


Met Val  Leu Leu Glu Lys Lys  Pro Asp Val Gln Leu  Thr Gly Gln 
    1550                 1555                 1560             


His Met  Ser Ile Ile Tyr Glu  Glu Thr Asn Thr Pro  Arg Pro Asp 
    1565                 1570                 1575             


Arg Leu  His His Gly Arg Val  His Val Val Glu Gly  Asn Phe Arg 
    1580                 1585                 1590             


His Ala  Ser Ser Arg Ala Pro  Val Ser Arg Glu Glu  Leu Met Thr 
    1595                 1600                 1605             


Val Leu  Ser Arg Leu Ala Asp  Val Arg Ile Gln Gly  Leu Tyr Phe 
    1610                 1615                 1620             


Thr Glu  Thr Gln Arg Leu Thr  Leu Ser Glu Val Gly  Leu Glu Glu 
    1625                 1630                 1635             


Ala Ser  Asp Thr Gly Ser Gly  Arg Ile Ala Leu Ala  Val Glu Ile 
    1640                 1645                 1650             


Cys Ala  Cys Pro Pro Ala Tyr  Ala Gly Asp Ser Cys  Gln Gly Cys 
    1655                 1660                 1665             


Ser Pro  Gly Tyr Tyr Arg Asp  His Lys Gly Leu Tyr  Thr Gly Arg 
    1670                 1675                 1680             


Cys Val  Pro Cys Asn Cys Asn  Gly His Ser Asn Gln  Cys Gln Asp 
    1685                 1690                 1695             


Gly Ser  Gly Ile Cys Val Asn  Cys Gln His Asn Thr  Ala Gly Glu 
    1700                 1705                 1710             


His Cys  Glu Arg Cys Gln Glu  Gly Tyr Tyr Gly Asn  Ala Val His 
    1715                 1720                 1725             


Gly Ser  Cys Arg Ala Cys Pro  Cys Pro His Thr Asn  Ser Phe Ala 
    1730                 1735                 1740             


Thr Gly  Cys Val Val Asn Gly  Gly Asp Val Arg Cys  Ser Cys Lys 
    1745                 1750                 1755             


Ala Gly  Tyr Thr Gly Thr Gln  Cys Glu Arg Cys Ala  Pro Gly Tyr 
    1760                 1765                 1770             


Phe Gly  Asn Pro Gln Lys Phe  Gly Gly Ser Cys Gln  Pro Cys Ser 
    1775                 1780                 1785             


Cys Asn  Ser Asn Gly Gln Leu  Gly Ser Cys His Pro  Leu Thr Gly 
    1790                 1795                 1800             


Asp Cys  Ile Asn Gln Glu Pro  Lys Asp Ser Ser Pro  Ala Glu Glu 
    1805                 1810                 1815             


Cys Asp  Asp Cys Asp Ser Cys  Val Met Thr Leu Leu  Asn Asp Leu 
    1820                 1825                 1830             


Ala Thr  Met Gly Glu Gln Leu  Arg Leu Val Lys Ser  Gln Leu Gln 
    1835                 1840                 1845             


Gly Leu  Ser Ala Ser Ala Gly  Leu Leu Glu Gln Met  Arg His Met 
    1850                 1855                 1860             


Glu Thr  Gln Ala Lys Asp Leu  Arg Asn Gln Leu Leu  Asn Tyr Arg 
    1865                 1870                 1875             


Ser Ala  Ile Ser Asn His Gly  Ser Lys Ile Glu Gly  Leu Glu Arg 
    1880                 1885                 1890             


Glu Leu  Thr Asp Leu Asn Gln  Glu Phe Glu Thr Leu  Gln Glu Lys 
    1895                 1900                 1905             


Ala Gln  Val Asn Ser Arg Lys  Ala Gln Thr Leu Asn  Asn Asn Val 
    1910                 1915                 1920             


Asn Arg  Ala Thr Gln Ser Ala  Lys Glu Leu Asp Val  Lys Ile Lys 
    1925                 1930                 1935             


Asn Val  Ile Arg Asn Val His  Ile Leu Leu Lys Gln  Ile Ser Gly 
    1940                 1945                 1950             


Thr Asp  Gly Glu Gly Asn Asn  Val Pro Ser Gly Asp  Phe Ser Arg 
    1955                 1960                 1965             


Glu Trp  Ala Glu Ala Gln Arg  Met Met Arg Glu Leu  Arg Asn Arg 
    1970                 1975                 1980             


Asn Phe  Gly Lys His Leu Arg  Glu Ala Glu Ala Asp  Lys Arg Glu 
    1985                 1990                 1995             


Ser Gln  Leu Leu Leu Asn Arg  Ile Arg Thr Trp Gln  Lys Thr His 
    2000                 2005                 2010             


Gln Gly  Glu Asn Asn Gly Leu  Ala Asn Ser Ile Arg  Asp Ser Leu 
    2015                 2020                 2025             


Asn Glu  Tyr Glu Ala Lys Leu  Ser Asp Leu Arg Ala  Arg Leu Gln 
    2030                 2035                 2040             


Glu Ala  Ala Ala Gln Ala Lys  Gln Ala Asn Gly Leu  Asn Gln Glu 
    2045                 2050                 2055             


Asn Glu  Arg Ala Leu Gly Ala  Ile Gln Arg Gln Val  Lys Glu Ile 
    2060                 2065                 2070             


Asn Ser  Leu Gln Ser Asp Phe  Thr Lys Tyr Leu Thr  Thr Ala Asp 
    2075                 2080                 2085             


Ser Ser  Leu Leu Gln Thr Asn  Ile Ala Leu Gln Leu  Met Glu Lys 
    2090                 2095                 2100             


Ser Gln  Lys Glu Tyr Glu Lys  Leu Ala Ala Ser Leu  Asn Glu Ala 
    2105                 2110                 2115             


Arg Gln  Glu Leu Ser Asp Lys  Val Arg Glu Leu Ser  Arg Ser Ala 
    2120                 2125                 2130             


Gly Lys  Thr Ser Leu Val Glu  Glu Ala Glu Lys His  Ala Arg Ser 
    2135                 2140                 2145             


Leu Gln  Glu Leu Ala Lys Gln  Leu Glu Glu Ile Lys  Arg Asn Ala 
    2150                 2155                 2160             


Ser Gly  Asp Glu Leu Val Arg  Cys Ala Val Asp Ala  Ala Thr Ala 
    2165                 2170                 2175             


Tyr Glu  Asn Ile Leu Asn Ala  Ile Lys Ala Ala Glu  Asp Ala Ala 
    2180                 2185                 2190             


Asn Arg  Ala Ala Ser Ala Ser  Glu Ser Ala Leu Gln  Thr Val Ile 
    2195                 2200                 2205             


Lys Glu  Asp Leu Pro Arg Lys  Ala Lys Thr Leu Ser  Ser Asn Ser 
    2210                 2215                 2220             


Asp Lys  Leu Leu Asn Glu Ala  Lys Met Thr Gln Lys  Lys Leu Lys 
    2225                 2230                 2235             


Gln Glu  Val Ser Pro Ala Leu  Asn Asn Leu Gln Gln  Thr Leu Asn 
    2240                 2245                 2250             


Ile Val  Thr Val Gln Lys Glu  Val Ile Asp Thr Asn  Leu Thr Thr 
    2255                 2260                 2265             


Leu Arg  Asp Gly Leu His Gly  Ile Gln Arg Gly Asp  Ile Asp Ala 
    2270                 2275                 2280             


Met Ile  Ser Ser Ala Lys Ser  Met Val Arg Lys Ala  Asn Asp Ile 
    2285                 2290                 2295             


Thr Asp  Glu Val Leu Asp Gly  Leu Asn Pro Ile Gln  Thr Asp Val 
    2300                 2305                 2310             


Glu Arg  Ile Lys Asp Thr Tyr  Gly Arg Thr Gln Asn  Glu Asp Phe 
    2315                 2320                 2325             


Lys Lys  Ala Leu Thr Asp Ala  Asp Asn Ser Val Asn  Lys Leu Thr 
    2330                 2335                 2340             


Asn Lys  Leu Pro Asp Leu Trp  Arg Lys Ile Glu Ser  Ile Asn Gln 
    2345                 2350                 2355             


Gln Leu  Leu Pro Leu Gly Asn  Ile Ser Asp Asn Met  Asp Arg Ile 
    2360                 2365                 2370             


Arg Glu  Leu Ile Gln Gln Ala  Arg Asp Ala Ala Ser  Lys Val Ala 
    2375                 2380                 2385             


Val Pro  Met Arg Phe Asn Gly  Lys Ser Gly Val Glu  Val Arg Leu 
    2390                 2395                 2400             


Pro Asn  Asp Leu Glu Asp Leu  Lys Gly Tyr Thr Ser  Leu Ser Leu 
    2405                 2410                 2415             


Phe Leu  Gln Arg Pro Asn Ser  Arg Glu Asn Gly Gly  Thr Glu Asn 
    2420                 2425                 2430             


Met Phe  Val Met Tyr Leu Gly  Asn Lys Asp Ala Ser  Arg Asp Tyr 
    2435                 2440                 2445             


Ile Gly  Met Ala Val Val Asp  Gly Gln Leu Thr Cys  Val Tyr Asn 
    2450                 2455                 2460             


Leu Gly  Asp Arg Glu Ala Glu  Leu Gln Val Asp Gln  Ile Leu Thr 
    2465                 2470                 2475             


Lys Ser  Glu Thr Lys Glu Ala  Val Met Asp Arg Val  Lys Phe Gln 
    2480                 2485                 2490             


Arg Ile  Tyr Gln Phe Ala Arg  Leu Asn Tyr Thr Lys  Gly Ala Thr 
    2495                 2500                 2505             


Ser Ser  Lys Pro Glu Thr Pro  Gly Val Tyr Asp Met  Asp Gly Arg 
    2510                 2515                 2520             


Asn Ser  Asn Thr Leu Leu Asn  Leu Asp Pro Glu Asn  Val Val Phe 
    2525                 2530                 2535             


Tyr Val  Gly Gly Tyr Pro Pro  Asp Phe Lys Leu Pro  Ser Arg Leu 
    2540                 2545                 2550             


Ser Phe  Pro Pro Tyr Lys Gly  Cys Ile Glu Leu Asp  Asp Leu Asn 
    2555                 2560                 2565             


Glu Asn  Val Leu Ser Leu Tyr  Asn Phe Lys Lys Thr  Phe Asn Leu 
    2570                 2575                 2580             


Asn Thr  Thr Glu Val Glu Pro  Cys Arg Arg Arg Lys  Glu Glu Ser 
    2585                 2590                 2595             


Asp Lys  Asn Tyr Phe Glu Gly  Thr Gly Tyr Ala Arg  Val Pro Thr 
    2600                 2605                 2610             


Gln Pro  His Ala Pro Ile Pro  Thr Phe Gly Gln Thr  Ile Gln Thr 
    2615                 2620                 2625             


Thr Val  Asp Arg Gly Leu Leu  Phe Phe Ala Glu Asn  Gly Asp Arg 
    2630                 2635                 2640             


Phe Ile  Ser Leu Asn Ile Glu  Asp Gly Lys Leu Met  Val Arg Tyr 
    2645                 2650                 2655             


Lys Leu  Asn Ser Glu Leu Pro  Lys Glu Arg Gly Val  Gly Asp Ala 
    2660                 2665                 2670             


Ile Asn  Asn Gly Arg Asp His  Ser Ile Gln Ile Lys  Ile Gly Lys 
    2675                 2680                 2685             


Leu Gln  Lys Arg Met Trp Ile  Asn Val Asp Val Gln  Asn Thr Ile 
    2690                 2695                 2700             


Ile Asp  Gly Glu Val Phe Asp  Phe Ser Thr Tyr Tyr  Leu Gly Gly 
    2705                 2710                 2715             


Ile Pro  Ile Ala Ile Arg Glu  Arg Phe Asn Ile Ser  Thr Pro Ala 
    2720                 2725                 2730             


Phe Arg  Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
    2735                 2740                 2745             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    2750                 2755                 2760             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    2765                 2770                 2775             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    2780                 2785                 2790             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    2795                 2800                 2805             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    2810                 2815                 2820             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Gly Pro  Ile Phe Lys 
    2825                 2830                 2835             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    2840                 2845                 2850             


Ile Ser  Asp Asn Ser Gly Leu  Arg Leu Leu Ile Asp  Asp Gln Leu 
    2855                 2860                 2865             


Leu Arg  Asn Ser Lys Arg Leu  Lys His Ile Ser Ser  Ser Arg Gln 
    2870                 2875                 2880             


Ser Leu  Arg Leu Gly Gly Ser  Asn Phe Glu Gly Cys  Ile Ser Asn 
    2885                 2890                 2895             


Val Phe  Val Gln Arg Leu Ser  Leu Ser Pro Glu Val  Leu Asp Leu 
    2900                 2905                 2910             


Thr Ser  Asn Ser Leu Lys Arg  Asp Val Ser Leu Gly  Gly Cys Ser 
    2915                 2920                 2925             


Leu Asn  Lys Pro Pro Phe Leu  Met Leu Leu Lys Gly  Ser Thr Arg 
    2930                 2935                 2940             


Phe Asn  Lys Thr Lys Thr Phe  Arg Ile Asn Gln Leu  Leu Gln Asp 
    2945                 2950                 2955             


Thr Pro  Val Ala Ser Pro Arg  Ser Val Lys Val Trp  Gln Asp Ala 
    2960                 2965                 2970             


Cys Ser  Pro Leu Pro Lys Thr  Gln Ala Asn His Gly  Ala Leu Gln 
    2975                 2980                 2985             


Phe Gly  Asp Ile Pro Thr Ser  His Leu Leu Phe Lys  Leu Pro Gln 
    2990                 2995                 3000             


Glu Leu  Leu Lys Pro Arg Ser  Gln Phe Ala Val Asp  Met Gln Thr 
    3005                 3010                 3015             


Thr Ser  Ser Arg Gly Leu Val  Phe His Thr Gly Thr  Lys Asn Ser 
    3020                 3025                 3030             


Phe Met  Ala Leu Tyr Leu Ser  Lys Gly Arg Leu Val  Phe Ala Leu 
    3035                 3040                 3045             


Gly Thr  Asp Gly Lys Lys Leu  Arg Ile Lys Ser Lys  Glu Lys Cys 
    3050                 3055                 3060             


Asn Asp  Gly Lys Trp His Thr  Val Val Phe Gly His  Asp Gly Glu 
    3065                 3070                 3075             


Lys Gly  Arg Leu Val Val Asp  Gly Leu Arg Ala Arg  Glu Gly Ser 
    3080                 3085                 3090             


Leu Pro  Gly Asn Ser Thr Ile  Ser Ile Arg Ala Pro  Val Tyr Leu 
    3095                 3100                 3105             


Gly Ser  Pro Pro Ser Gly Lys  Pro Lys Ser Leu Pro  Thr Asn Ser 
    3110                 3115                 3120             


Phe Val  Gly Cys Leu Lys Asn  Phe Gln Leu Asp Ser  Lys Pro Leu 
    3125                 3130                 3135             


Tyr Thr  Pro Ser Ser Ser Phe  Gly Val Ser Ser Cys  Leu Gly Gly 
    3140                 3145                 3150             


Pro Leu  Glu Lys Gly Ile Tyr  Phe Ser Glu Glu Gly  Gly His Val 
    3155                 3160                 3165             


Val Leu  Ala His Ser Val Leu  Leu Gly Pro Glu Phe  Lys Leu Val 
    3170                 3175                 3180             


Phe Ser  Ile Arg Pro Arg Ser  Leu Thr Gly Ile Leu  Ile His Ile 
    3185                 3190                 3195             


Gly Ser  Gln Pro Gly Lys His  Leu Cys Val Tyr Leu  Glu Ala Gly 
    3200                 3205                 3210             


Lys Val  Thr Ala Ser Met Asp  Ser Gly Ala Gly Gly  Thr Ser Thr 
    3215                 3220                 3225             


Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp Gly Gln  Trp His Ser 
    3230                 3235                 3240             


Val Ala  Val Thr Ile Lys Gln  His Ile Leu His Leu  Glu Leu Asp 
    3245                 3250                 3255             


Thr Asp  Ser Ser Tyr Thr Ala  Gly Gln Ile Pro Phe  Pro Pro Ala 
    3260                 3265                 3270             


Ser Thr  Gln Glu Pro Leu His  Leu Gly Gly Ala Pro  Ala Asn Leu 
    3275                 3280                 3285             


Thr Thr  Leu Arg Ile Pro Val  Trp Lys Ser Phe Phe  Gly Cys Leu 
    3290                 3295                 3300             


Arg Asn  Ile His Val Asn His  Ile Pro Val Pro Val  Thr Glu Ala 
    3305                 3310                 3315             


Leu Glu  Val Gln Gly Pro Val  Ser Leu Asn Gly Cys  Pro Asp Gln 
    3320                 3325                 3330             


<210>  48
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Ser Trp Ser Arg Gln Arg Pro Lys Ser Pro Gly Gly Ile Gln 
1               5                   10                  15      


Pro His Val Ser Arg Thr Leu Phe Leu Leu Leu Leu Leu Ala Ala Ser 
            20                  25                  30          


Ala Trp Gly Val Thr Leu Ser Pro Lys Asp Cys Gln Val Phe Arg Ser 
        35                  40                  45              


Asp His Gly Ser Ser Ile Ser Cys Gln Pro Pro Ala Glu Ile Pro Gly 
    50                  55                  60                  


Tyr Leu Pro Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu 
65                  70                  75                  80  


Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys Leu Gln Glu 
                85                  90                  95      


Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu 
            100                 105                 110         


Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu 
        115                 120                 125             


Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr Leu Asp Thr 
    130                 135                 140                 


Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val Ser Trp Leu 
145                 150                 155                 160 


His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu 
                165                 170                 175     


Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr 
            180                 185                 190         


Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro Asp Leu Leu 
        195                 200                 205             


Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu 
    210                 215                 220                 


Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg Tyr 
225                 230                 235                 240 


Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe 
                245                 250                 255     


Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu 
            260                 265                 270         


Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp 
        275                 280                 285             


Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp 
    290                 295                 300                 


Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln Lys Asp Lys 
305                 310                 315                 320 


Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys 
                325                 330                 335     


Gly Gln Thr Leu Leu Ala Val Ala Lys Ser Gln 
            340                 345         


<210>  49
<211>  4655
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  50
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Pro Asn Cys Ser Cys Ser Pro Val Gly Ser Cys Ala Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Thr Ser Asp Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  51
<211>  1140
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu 
1               5                   10                  15      


Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn 
            20                  25                  30          


Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr 
        35                  40                  45              


Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu 
    50                  55                  60                  


Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr 
65                  70                  75                  80  


Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro 
                85                  90                  95      


Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys 
            100                 105                 110         


Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro 
        115                 120                 125             


Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp 
    130                 135                 140                 


Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys 
145                 150                 155                 160 


Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp 
                165                 170                 175     


Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His 
            180                 185                 190         


Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly 
        195                 200                 205             


Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu 
    210                 215                 220                 


Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys 
225                 230                 235                 240 


Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro 
                245                 250                 255     


Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg 
            260                 265                 270         


Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr 
        275                 280                 285             


Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly 
    290                 295                 300                 


Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys 
305                 310                 315                 320 


Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser 
                325                 330                 335     


Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala 
            340                 345                 350         


Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys 
        355                 360                 365             


Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu 
    370                 375                 380                 


Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys 
385                 390                 395                 400 


Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln 
                405                 410                 415     


Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro 
            420                 425                 430         


Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr 
        435                 440                 445             


Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys 
    450                 455                 460                 


Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val 
465                 470                 475                 480 


Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn 
                485                 490                 495     


Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly 
            500                 505                 510         


Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro 
        515                 520                 525             


Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys 
    530                 535                 540                 


Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu 
545                 550                 555                 560 


Pro Gly Trp Ser Gly Val His Cys Asp Ser Val Cys Ala Glu Gly Arg 
                565                 570                 575     


Trp Gly Pro Asn Cys Ser Leu Pro Cys Tyr Cys Lys Asn Gly Ala Ser 
            580                 585                 590         


Cys Ser Pro Asp Asp Gly Ile Cys Glu Cys Ala Pro Gly Phe Arg Gly 
        595                 600                 605             


Thr Thr Cys Gln Arg Ile Cys Ser Pro Gly Phe Tyr Gly His Arg Cys 
    610                 615                 620                 


Ser Gln Thr Cys Pro Gln Cys Val His Ser Ser Gly Pro Cys His His 
625                 630                 635                 640 


Ile Thr Gly Leu Cys Asp Cys Leu Pro Gly Phe Thr Gly Ala Leu Cys 
                645                 650                 655     


Asn Glu Val Cys Pro Ser Gly Arg Phe Gly Lys Asn Cys Ala Gly Ile 
            660                 665                 670         


Cys Thr Cys Thr Asn Asn Gly Thr Cys Asn Pro Ile Asp Arg Ser Cys 
        675                 680                 685             


Gln Cys Tyr Pro Gly Trp Ile Gly Ser Asp Cys Ser Gln Pro Cys Pro 
    690                 695                 700                 


Pro Ala His Trp Gly Pro Asn Cys Ile His Thr Cys Asn Cys His Asn 
705                 710                 715                 720 


Gly Ala Phe Cys Ser Ala Tyr Asp Gly Glu Cys Lys Cys Thr Pro Gly 
                725                 730                 735     


Trp Thr Gly Leu Tyr Cys Thr Gln Arg Cys Pro Leu Gly Phe Tyr Gly 
            740                 745                 750         


Lys Asp Cys Ala Leu Ile Cys Gln Cys Gln Asn Gly Ala Asp Cys Asp 
        755                 760                 765             


His Ile Ser Gly Gln Cys Thr Cys Arg Thr Gly Phe Met Gly Arg His 
    770                 775                 780                 


Cys Glu Gln Lys Cys Pro Ser Gly Thr Tyr Gly Tyr Gly Cys Arg Gln 
785                 790                 795                 800 


Ile Cys Asp Cys Leu Asn Asn Ser Thr Cys Asp His Ile Thr Gly Thr 
                805                 810                 815     


Cys Tyr Cys Ser Pro Gly Trp Lys Gly Ala Arg Cys Asp Gln Ala Gly 
            820                 825                 830         


Val Ile Ile Val Gly Asn Leu Asn Ser Leu Ser Arg Thr Ser Thr Ala 
        835                 840                 845             


Leu Pro Ala Asp Ser Tyr Gln Ile Gly Ala Ile Ala Gly Ile Ile Ile 
    850                 855                 860                 


Leu Val Leu Val Val Leu Phe Leu Leu Ala Leu Phe Ile Ile Tyr Arg 
865                 870                 875                 880 


His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro Ala Val Thr Tyr Thr 
                885                 890                 895     


Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser Gly Thr Leu 
            900                 905                 910         


Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe Thr Asn Pro 
        915                 920                 925             


Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His Val Asn Asn 
    930                 935                 940                 


Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln Leu Phe Val 
945                 950                 955                 960 


Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val Gly Asp Cys 
                965                 970                 975     


Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr Leu Asn Glu 
            980                 985                 990         


Leu Gly Ala Phe Gly Leu Asp Arg  Ser Tyr Met Gly Lys  Ser Leu Lys 
        995                 1000                 1005             


Asp Leu  Gly Lys Asn Ser Glu  Tyr Asn Ser Ser Asn  Cys Ser Leu 
    1010                 1015                 1020             


Ser Ser  Ser Glu Asn Pro Tyr  Ala Thr Ile Lys Asp  Pro Pro Val 
    1025                 1030                 1035             


Leu Ile  Pro Lys Ser Ser Glu  Cys Gly Tyr Val Glu  Met Lys Ser 
    1040                 1045                 1050             


Pro Ala  Arg Arg Asp Ser Pro  Tyr Ala Glu Ile Asn  Asn Ser Thr 
    1055                 1060                 1065             


Ser Ala  Asn Arg Asn Val Tyr  Glu Val Glu Pro Thr  Val Ser Val 
    1070                 1075                 1080             


Val Gln  Gly Val Phe Ser Asn  Asn Gly Arg Leu Ser  Gln Asp Pro 
    1085                 1090                 1095             


Tyr Asp  Leu Pro Lys Asn Ser  His Ile Pro Cys His  Tyr Asp Leu 
    1100                 1105                 1110             


Leu Pro  Val Arg Asp Ser Ser  Ser Ser Pro Lys Gln  Glu Asp Ser 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Asn Ser  Ser Ser Ser Ser Glu  
    1130                 1135                 1140 


<210>  52
<211>  2385
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Pro Val Leu Gly Val Ala Ser Lys Leu Arg Gln Pro Ala Val Gly 
1               5                   10                  15      


Ser Lys Pro Val His Thr Ala Leu Pro Ile Pro Asn Leu Gly Thr Thr 
            20                  25                  30          


Gly Ser Gln His Cys Ser Ser Arg Pro Leu Glu Leu Thr Glu Thr Glu 
        35                  40                  45              


Ser Ser Met Leu Ser Cys Gln Leu Ala Leu Lys Ser Thr Cys Glu Phe 
    50                  55                  60                  


Gly Glu Lys Lys Pro Leu Gln Gly Lys Ala Lys Glu Lys Glu Asp Ser 
65                  70                  75                  80  


Lys Ile Tyr Thr Asp Trp Ala Asn His Tyr Leu Ala Lys Ser Gly His 
                85                  90                  95      


Lys Arg Leu Ile Lys Asp Leu Gln Gln Asp Ile Ala Asp Gly Val Leu 
            100                 105                 110         


Leu Ala Glu Ile Ile Gln Ile Ile Ala Asn Glu Lys Val Glu Asp Ile 
        115                 120                 125             


Asn Gly Cys Pro Arg Ser Gln Ser Gln Met Ile Glu Asn Val Asp Val 
    130                 135                 140                 


Cys Leu Ser Phe Leu Ala Ala Arg Gly Val Asn Val Gln Gly Leu Ser 
145                 150                 155                 160 


Ala Glu Glu Ile Arg Asn Gly Asn Leu Lys Ala Ile Leu Gly Leu Phe 
                165                 170                 175     


Phe Ser Leu Ser Arg Tyr Lys Gln Gln Gln His His Gln Gln Gln Tyr 
            180                 185                 190         


Tyr Gln Ser Leu Val Glu Leu Gln Gln Arg Val Thr His Ala Ser Pro 
        195                 200                 205             


Pro Ser Glu Ala Ser Gln Ala Lys Thr Gln Gln Asp Met Gln Ser Ser 
    210                 215                 220                 


Leu Ala Ala Arg Tyr Ala Thr Gln Ser Asn His Ser Gly Ile Ala Thr 
225                 230                 235                 240 


Ser Gln Lys Lys Pro Thr Arg Leu Pro Gly Pro Ser Arg Val Pro Ala 
                245                 250                 255     


Ala Gly Ser Ser Ser Lys Val Gln Gly Ala Ser Asn Leu Asn Arg Arg 
            260                 265                 270         


Ser Gln Ser Phe Asn Ser Ile Asp Lys Asn Lys Pro Pro Asn Tyr Ala 
        275                 280                 285             


Asn Gly Asn Glu Lys Asp Ser Ser Lys Gly Pro Gln Ser Ser Ser Gly 
    290                 295                 300                 


Val Asn Gly Asn Val Gln Pro Pro Ser Thr Ala Gly Gln Pro Pro Ala 
305                 310                 315                 320 


Ser Ala Ile Pro Ser Pro Ser Ala Ser Lys Pro Trp Arg Ser Lys Ser 
                325                 330                 335     


Met Asn Val Lys His Ser Ala Thr Ser Thr Met Leu Thr Val Lys Gln 
            340                 345                 350         


Ser Ser Thr Ala Thr Ser Pro Thr Pro Ser Ser Asp Arg Leu Lys Pro 
        355                 360                 365             


Pro Val Ser Glu Gly Val Lys Thr Ala Pro Ser Gly Gln Lys Ser Met 
    370                 375                 380                 


Leu Glu Lys Phe Lys Leu Val Asn Ala Arg Thr Ala Leu Arg Pro Pro 
385                 390                 395                 400 


Gln Pro Pro Ser Ser Gly Pro Ser Asp Gly Gly Lys Asp Asp Asp Ala 
                405                 410                 415     


Phe Ser Glu Ser Gly Glu Met Glu Gly Phe Asn Ser Gly Leu Asn Ser 
            420                 425                 430         


Gly Gly Ser Thr Asn Ser Ser Pro Lys Val Ser Pro Lys Leu Ala Pro 
        435                 440                 445             


Pro Lys Ala Gly Ser Lys Asn Leu Ser Asn Lys Lys Ser Leu Leu Gln 
    450                 455                 460                 


Pro Lys Glu Lys Glu Glu Lys Asn Arg Asp Lys Asn Lys Val Cys Thr 
465                 470                 475                 480 


Glu Lys Pro Val Lys Glu Glu Lys Asp Gln Val Thr Glu Met Ala Pro 
                485                 490                 495     


Lys Lys Thr Ser Lys Ile Ala Ser Leu Ile Pro Lys Gly Ser Lys Thr 
            500                 505                 510         


Thr Ala Ala Lys Lys Glu Ser Leu Ile Pro Ser Ser Ser Gly Ile Pro 
        515                 520                 525             


Lys Pro Gly Ser Lys Val Pro Thr Val Lys Gln Thr Ile Ser Pro Gly 
    530                 535                 540                 


Ser Thr Ala Ser Lys Glu Ser Glu Lys Phe Arg Thr Thr Lys Gly Ser 
545                 550                 555                 560 


Pro Ser Gln Ser Leu Ser Lys Pro Ile Thr Met Glu Lys Ala Ser Ala 
                565                 570                 575     


Ser Ser Cys Pro Ala Pro Leu Glu Gly Arg Glu Ala Gly Gln Ala Ser 
            580                 585                 590         


Pro Ser Gly Ser Cys Thr Met Thr Val Ala Gln Ser Ser Gly Gln Ser 
        595                 600                 605             


Thr Gly Asn Gly Ala Val Gln Leu Pro Gln Gln Gln Gln His Ser His 
    610                 615                 620                 


Pro Asn Thr Ala Thr Val Ala Pro Phe Ile Tyr Arg Ala His Ser Glu 
625                 630                 635                 640 


Asn Glu Gly Thr Ala Leu Pro Ser Ala Asp Ser Cys Thr Ser Pro Thr 
                645                 650                 655     


Lys Met Asp Leu Ser Tyr Ser Lys Thr Ala Lys Gln Cys Leu Glu Glu 
            660                 665                 670         


Ile Ser Gly Glu Asp Pro Glu Thr Arg Arg Met Arg Thr Val Lys Asn 
        675                 680                 685             


Ile Ala Asp Leu Arg Gln Asn Leu Glu Glu Thr Met Ser Ser Leu Arg 
    690                 695                 700                 


Gly Thr Gln Ile Ser His Ser Thr Leu Glu Thr Thr Phe Asp Ser Thr 
705                 710                 715                 720 


Val Thr Thr Glu Val Asn Gly Arg Thr Ile Pro Asn Leu Thr Ser Arg 
                725                 730                 735     


Pro Thr Pro Met Thr Trp Arg Leu Gly Gln Ala Cys Pro Arg Leu Gln 
            740                 745                 750         


Ala Gly Asp Ala Pro Ser Leu Gly Ala Gly Tyr Pro Arg Ser Gly Thr 
        755                 760                 765             


Ser Arg Phe Ile His Thr Asp Pro Ser Arg Phe Met Tyr Thr Thr Pro 
    770                 775                 780                 


Leu Arg Arg Ala Ala Val Ser Arg Leu Gly Asn Met Ser Gln Ile Asp 
785                 790                 795                 800 


Met Ser Glu Lys Ala Ser Ser Asp Leu Asp Met Ser Ser Glu Val Asp 
                805                 810                 815     


Val Gly Gly Tyr Met Ser Asp Gly Asp Ile Leu Gly Lys Ser Leu Arg 
            820                 825                 830         


Thr Asp Asp Ile Asn Ser Gly Tyr Met Thr Asp Gly Gly Leu Asn Leu 
        835                 840                 845             


Tyr Thr Arg Ser Leu Asn Arg Ile Pro Asp Thr Ala Thr Ser Arg Asp 
    850                 855                 860                 


Ile Ile Gln Arg Gly Val His Asp Val Thr Val Asp Ala Asp Ser Trp 
865                 870                 875                 880 


Asp Asp Ser Ser Ser Val Ser Ser Gly Leu Ser Asp Thr Leu Asp Asn 
                885                 890                 895     


Ile Ser Thr Asp Asp Leu Asn Thr Thr Ser Ser Val Ser Ser Tyr Ser 
            900                 905                 910         


Asn Ile Thr Val Pro Ser Arg Lys Asn Thr Gln Leu Arg Thr Asp Ser 
        915                 920                 925             


Glu Lys Arg Ser Thr Thr Asp Glu Thr Trp Asp Ser Pro Glu Glu Leu 
    930                 935                 940                 


Lys Lys Pro Glu Glu Asp Phe Asp Ser His Gly Asp Ala Gly Gly Lys 
945                 950                 955                 960 


Trp Lys Thr Val Ser Ser Gly Leu Pro Glu Asp Pro Glu Lys Ala Gly 
                965                 970                 975     


Gln Lys Ala Ser Leu Ser Val Ser Gln Thr Gly Ser Trp Arg Arg Gly 
            980                 985                 990         


Met Ser Ala Gln Gly Gly Ala Pro  Ser Arg Gln Lys Ala  Gly Thr Ser 
        995                 1000                 1005             


Ala Leu  Lys Thr Pro Gly Lys  Thr Asp Asp Ala Lys  Ala Ser Glu 
    1010                 1015                 1020             


Lys Gly  Lys Ala Pro Leu Lys  Gly Ser Ser Leu Gln  Arg Ser Pro 
    1025                 1030                 1035             


Ser Asp  Ala Gly Lys Ser Ser  Gly Asp Glu Gly Lys  Lys Pro Pro 
    1040                 1045                 1050             


Ser Gly  Ile Gly Arg Ser Thr  Ala Thr Ser Ser Phe  Gly Phe Lys 
    1055                 1060                 1065             


Lys Pro  Ser Gly Val Gly Ser  Ser Ala Met Ile Thr  Ser Ser Gly 
    1070                 1075                 1080             


Ala Thr  Ile Thr Ser Gly Ser  Ala Thr Leu Gly Lys  Ile Pro Lys 
    1085                 1090                 1095             


Ser Ala  Ala Ile Gly Gly Lys  Ser Asn Ala Gly Arg  Lys Thr Ser 
    1100                 1105                 1110             


Leu Asp  Gly Ser Gln Asn Gln  Asp Asp Val Val Leu  His Val Ser 
    1115                 1120                 1125             


Ser Lys  Thr Thr Leu Gln Tyr  Arg Ser Leu Pro Arg  Pro Ser Lys 
    1130                 1135                 1140             


Ser Ser  Thr Ser Gly Ile Pro  Gly Arg Gly Gly His  Arg Ser Ser 
    1145                 1150                 1155             


Thr Ser  Ser Ile Asp Ser Asn  Val Ser Ser Lys Ser  Ala Gly Ala 
    1160                 1165                 1170             


Thr Thr  Ser Lys Leu Arg Glu  Pro Thr Lys Ile Gly  Ser Gly Arg 
    1175                 1180                 1185             


Ser Ser  Pro Val Thr Val Asn  Gln Thr Asp Lys Glu  Lys Glu Lys 
    1190                 1195                 1200             


Val Ala  Val Ser Asp Ser Glu  Ser Val Ser Leu Ser  Gly Ser Pro 
    1205                 1210                 1215             


Lys Ser  Ser Pro Thr Ser Ala  Ser Ala Cys Gly Ala  Gln Gly Leu 
    1220                 1225                 1230             


Arg Gln  Pro Gly Ser Lys Tyr  Pro Asp Ile Ala Ser  Pro Thr Phe 
    1235                 1240                 1245             


Arg Arg  Leu Phe Gly Ala Lys  Ala Gly Gly Lys Ser  Ala Ser Ala 
    1250                 1255                 1260             


Pro Asn  Thr Glu Gly Val Lys  Ser Ser Ser Val Met  Pro Ser Pro 
    1265                 1270                 1275             


Ser Thr  Thr Leu Ala Arg Gln  Gly Ser Leu Glu Ser  Pro Ser Ser 
    1280                 1285                 1290             


Gly Thr  Gly Ser Met Gly Ser  Ala Gly Gly Leu Ser  Gly Ser Ser 
    1295                 1300                 1305             


Ser Pro  Leu Phe Asn Lys Pro  Ser Asp Leu Thr Thr  Asp Val Ile 
    1310                 1315                 1320             


Ser Leu  Ser His Ser Leu Ala  Ser Ser Pro Ala Ser  Val His Ser 
    1325                 1330                 1335             


Phe Thr  Ser Gly Gly Leu Val  Trp Ala Ala Asn Met  Ser Ser Ser 
    1340                 1345                 1350             


Ser Ala  Gly Ser Lys Asp Thr  Pro Ser Tyr Gln Ser  Met Thr Ser 
    1355                 1360                 1365             


Leu His  Thr Ser Ser Glu Ser  Ile Asp Leu Pro Leu  Ser His His 
    1370                 1375                 1380             


Gly Ser  Leu Ser Gly Leu Thr  Thr Gly Thr His Glu  Val Gln Ser 
    1385                 1390                 1395             


Leu Leu  Met Arg Thr Gly Ser  Val Arg Ser Thr Leu  Ser Glu Ser 
    1400                 1405                 1410             


Met Gln  Leu Asp Arg Asn Thr  Leu Pro Lys Lys Gly  Leu Arg Tyr 
    1415                 1420                 1425             


Thr Pro  Ser Ser Arg Gln Ala  Asn Gln Glu Glu Gly  Lys Glu Trp 
    1430                 1435                 1440             


Leu Arg  Ser His Ser Thr Gly  Gly Leu Gln Asp Thr  Gly Asn Gln 
    1445                 1450                 1455             


Ser Pro  Leu Val Ser Pro Ser  Ala Met Ser Ser Ser  Ala Ala Gly 
    1460                 1465                 1470             


Lys Tyr  His Phe Ser Asn Leu  Val Ser Pro Thr Asn  Leu Ser Gln 
    1475                 1480                 1485             


Phe Asn  Leu Pro Gly Pro Ser  Met Met Arg Ser Asn  Ser Ile Pro 
    1490                 1495                 1500             


Ala Gln  Asp Ser Ser Phe Asp  Leu Tyr Asp Asp Ser  Gln Leu Cys 
    1505                 1510                 1515             


Gly Ser  Ala Thr Ser Leu Glu  Glu Arg Pro Arg Ala  Ile Ser His 
    1520                 1525                 1530             


Ser Gly  Ser Phe Arg Asp Ser  Met Glu Glu Val His  Gly Ser Ser 
    1535                 1540                 1545             


Leu Ser  Leu Val Ser Ser Thr  Ser Ser Leu Tyr Ser  Thr Ala Glu 
    1550                 1555                 1560             


Glu Lys  Ala His Ser Glu Gln  Ile His Lys Leu Arg  Arg Glu Leu 
    1565                 1570                 1575             


Val Ala  Ser Gln Glu Lys Val  Ala Thr Leu Thr Ser  Gln Leu Ser 
    1580                 1585                 1590             


Ala Asn  Ala His Leu Val Ala  Ala Phe Glu Lys Ser  Leu Gly Asn 
    1595                 1600                 1605             


Met Thr  Gly Arg Leu Gln Ser  Leu Thr Met Thr Ala  Glu Gln Lys 
    1610                 1615                 1620             


Glu Ser  Glu Leu Ile Glu Leu  Arg Glu Thr Ile Glu  Met Leu Lys 
    1625                 1630                 1635             


Ala Gln  Asn Ser Ala Ala Gln  Ala Ala Ile Gln Gly  Ala Leu Asn 
    1640                 1645                 1650             


Gly Pro  Asp His Pro Pro Lys  Asp Leu Arg Ile Arg  Arg Gln His 
    1655                 1660                 1665             


Ser Ser  Glu Ser Val Ser Ser  Ile Asn Ser Ala Thr  Ser His Ser 
    1670                 1675                 1680             


Ser Ile  Gly Ser Gly Asn Asp  Ala Asp Ser Lys Lys  Lys Lys Lys 
    1685                 1690                 1695             


Lys Asn  Trp Val Asn Ser Arg  Gly Ser Glu Leu Arg  Ser Ser Phe 
    1700                 1705                 1710             


Lys Gln  Ala Phe Gly Lys Lys  Lys Ser Thr Lys Pro  Pro Ser Ser 
    1715                 1720                 1725             


His Ser  Asp Ile Glu Glu Leu  Thr Asp Ser Ser Leu  Pro Ala Ser 
    1730                 1735                 1740             


Pro Lys  Leu Pro His Asn Ala  Gly Asp Cys Gly Ser  Ala Ser Met 
    1745                 1750                 1755             


Lys Pro  Ser Gln Ser Ala Ser  Ala Ser Pro Leu Val  Trp Pro Pro 
    1760                 1765                 1770             


Lys Lys  Arg Gln Asn Gly Pro  Val Ile Tyr Lys His  Arg Ser Arg 
    1775                 1780                 1785             


Ile Cys  Glu Cys Thr Glu Ala  Glu Ala Glu Ile Ile  Leu Gln Leu 
    1790                 1795                 1800             


Lys Ser  Glu Leu Arg Glu Lys  Glu Leu Lys Leu Thr  Asp Ile Arg 
    1805                 1810                 1815             


Leu Glu  Ala Leu Ser Ser Ala  His His Leu Asp Gln  Ile Arg Glu 
    1820                 1825                 1830             


Ala Met  Asn Arg Met Gln Asn  Glu Ile Glu Ile Leu  Lys Ala Glu 
    1835                 1840                 1845             


Asn Asp  Arg Leu Lys Ala Glu  Thr Gly Asn Thr Ala  Lys Pro Thr 
    1850                 1855                 1860             


Arg Pro  Pro Ser Glu Ser Ser  Ser Ser Thr Ser Ser  Ser Ser Ser 
    1865                 1870                 1875             


Arg Gln  Ser Leu Gly Leu Ser  Leu Asn Asn Leu Asn  Ile Thr Glu 
    1880                 1885                 1890             


Ala Val  Ser Ser Asp Ile Leu  Leu Asp Asp Ala Gly  Asp Ala Thr 
    1895                 1900                 1905             


Gly His  Lys Asp Gly Arg Ser  Val Lys Ile Ile Val  Ser Ile Ser 
    1910                 1915                 1920             


Lys Gly  Tyr Gly Arg Ala Lys  Asp Gln Lys Ser Gln  Ala Tyr Leu 
    1925                 1930                 1935             


Ile Gly  Ser Ile Gly Val Ser  Gly Lys Thr Lys Trp  Asp Val Leu 
    1940                 1945                 1950             


Asp Gly  Val Ile Arg Arg Leu  Phe Lys Glu Tyr Val  Phe Arg Ile 
    1955                 1960                 1965             


Asp Thr  Ser Thr Ser Leu Gly  Leu Ser Ser Asp Cys  Ile Ala Ser 
    1970                 1975                 1980             


Tyr Cys  Ile Gly Asp Leu Ile  Arg Ser His Asn Leu  Glu Val Pro 
    1985                 1990                 1995             


Glu Leu  Leu Pro Cys Gly Tyr  Leu Val Gly Asp Asn  Asn Ile Ile 
    2000                 2005                 2010             


Thr Val  Asn Leu Lys Gly Val  Glu Glu Asn Ser Leu  Asp Ser Phe 
    2015                 2020                 2025             


Val Phe  Asp Thr Leu Ile Pro  Lys Pro Ile Thr Gln  Arg Tyr Phe 
    2030                 2035                 2040             


Asn Leu  Leu Met Glu His His  Arg Ile Ile Leu Ser  Gly Pro Ser 
    2045                 2050                 2055             


Gly Thr  Gly Lys Thr Tyr Leu  Ala Asn Lys Leu Ala  Glu Tyr Val 
    2060                 2065                 2070             


Ile Thr  Lys Ser Gly Arg Lys  Lys Thr Glu Asp Ala  Ile Ala Thr 
    2075                 2080                 2085             


Phe Asn  Val Asp His Lys Ser  Ser Lys Glu Leu Gln  Gln Tyr Leu 
    2090                 2095                 2100             


Ala Asn  Leu Ala Glu Gln Cys  Ser Ala Asp Asn Asn  Gly Val Glu 
    2105                 2110                 2115             


Leu Pro  Val Val Ile Ile Leu  Asp Asn Leu His His  Val Gly Ser 
    2120                 2125                 2130             


Leu Ser  Asp Ile Phe Asn Gly  Phe Leu Asn Cys Lys  Tyr Asn Lys 
    2135                 2140                 2145             


Cys Pro  Tyr Ile Ile Gly Thr  Met Asn Gln Gly Val  Ser Ser Ser 
    2150                 2155                 2160             


Pro Asn  Leu Glu Leu His His  Asn Phe Arg Trp Val  Leu Cys Ala 
    2165                 2170                 2175             


Asn His  Thr Glu Pro Val Lys  Gly Phe Leu Gly Arg  Tyr Leu Arg 
    2180                 2185                 2190             


Arg Lys  Leu Ile Glu Ile Glu  Ile Glu Arg Asn Ile  Arg Asn Asn 
    2195                 2200                 2205             


Asp Leu  Val Lys Ile Ile Asp  Trp Ile Pro Lys Thr  Trp His His 
    2210                 2215                 2220             


Leu Asn  Ser Phe Leu Glu Thr  His Ser Ser Ser Asp  Val Thr Ile 
    2225                 2230                 2235             


Gly Pro  Arg Leu Phe Leu Pro  Cys Pro Met Asp Val  Glu Gly Ser 
    2240                 2245                 2250             


Arg Val  Trp Phe Met Asp Leu  Trp Asn Tyr Ser Leu  Val Pro Tyr 
    2255                 2260                 2265             


Ile Leu  Glu Ala Val Arg Glu  Gly Leu Gln Met Tyr  Gly Lys Arg 
    2270                 2275                 2280             


Thr Pro  Trp Glu Asp Pro Ser  Lys Trp Val Leu Asp  Thr Tyr Pro 
    2285                 2290                 2295             


Trp Ser  Ser Ala Thr Leu Pro  Gln Glu Ser Pro Ala  Leu Leu Gln 
    2300                 2305                 2310             


Leu Arg  Pro Glu Asp Val Gly  Tyr Glu Ser Cys Thr  Ser Thr Lys 
    2315                 2320                 2325             


Glu Ala  Thr Thr Ser Lys His  Ile Pro Gln Thr Asp  Thr Glu Gly 
    2330                 2335                 2340             


Asp Pro  Leu Met Asn Met Leu  Met Lys Leu Gln Glu  Ala Ala Asn 
    2345                 2350                 2355             


Tyr Ser  Ser Thr Gln Ser Cys  Asp Ser Glu Ser Thr  Ser His His 
    2360                 2365                 2370             


Glu Asp  Ile Leu Asp Ser Ser  Leu Glu Ser Thr Leu  
    2375                 2380                 2385 


<210>  53
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser 
1               5                   10                  15      


Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln 
            20                  25                  30          


Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His 
        35                  40                  45              


Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn 
    50                  55                  60                  


Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu 
65                  70                  75                  80  


Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu 
                85                  90                  95      


Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu 
            100                 105                 110         


Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu 
        115                 120                 125             


Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser 
    130                 135                 140                 


Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala 
145                 150                 155                 160 


Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly 
                165                 170                 175     


Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala 
            180                 185                 190         


Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala 
        195                 200                 205             


Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala 
    210                 215                 220                 


Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His 
225                 230                 235                 240 


Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg 
                245                 250                 255     


Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe 
            260                 265                 270         


Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg 
        275                 280                 285             


Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr 
    290                 295                 300                 


Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg 
305                 310                 315                 320 


Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val 
                325                 330                 335     


Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln 
            340                 345                 350         


Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala 
        355                 360                 365             


Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro 
    370                 375                 380                 


Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala 
                405                 410                 415     


Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met 
            420                 425                 430         


Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser 
        435                 440                 445             


Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His 
    450                 455                 460                 


Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val 
465                 470                 475                 480 


Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu 
                485                 490                 495     


Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu 
            500                 505                 510         


Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr 
        515                 520                 525             


Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His 
    530                 535                 540                 


Phe Thr Ala Thr Val Lys Pro Arg Pro Ala Arg Ser Val Ser Lys Arg 
545                 550                 555                 560 


Ser Arg Arg Glu Pro Pro Pro Arg Thr Leu Pro Ala Thr Asp Leu Gln 
                565                 570                 575     


<210>  54
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
625                 630                 635                 640 


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
                645                 650                 655     


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
            660                 665                 670         


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
        675                 680                 685             


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
    690                 695                 700                 


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
705                 710                 715                 720 


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
                725                 730                 735     


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
            740                 745                 750         


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
        755                 760                 765             


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
    770                 775                 780                 


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
785                 790                 795                 800 


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
                805                 810                 815     


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
            820                 825                 830         


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
        835                 840                 845             


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
    850                 855                 860                 


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Ala Thr Glu Glu Ser 
865                 870                 875                 880 


Trp Ala Glu Gly Gly Phe Cys Met Leu Val Lys Lys Asn Asn Leu Cys 
                885                 890                 895     


Gln Arg Lys Val Leu Gln Gln Leu Cys Cys Lys Thr Cys Thr Phe Gln 
            900                 905                 910         


Gly 
    


<210>  55
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Lys Ser Ser Val Ala Gln Ile Lys Pro Ser Ser Gly His Asp Arg 
1               5                   10                  15      


Arg Glu Asn Leu Asn Ser Tyr Gln Arg Asn Ser Ser Pro Glu Asp Arg 
            20                  25                  30          


Tyr Glu Glu Gln Glu Arg Ser Pro Arg Asp Arg Asp Tyr Phe Asp Tyr 
        35                  40                  45              


Ser Arg Ser Asp Tyr Glu His Ser Arg Arg Gly Arg Ser Tyr Asp Ser 
    50                  55                  60                  


Ser Met Glu Ser Arg Asn Arg Asp Arg Glu Lys Arg Arg Glu Arg Glu 
65                  70                  75                  80  


Arg Asp Thr Asp Arg Lys Arg Ser Arg Lys Ser Pro Ser Pro Gly Arg 
                85                  90                  95      


Arg Asn Pro Glu Thr Ser Val Thr Gln Ser Ser Ser Ala Gln Asp Glu 
            100                 105                 110         


Pro Ala Thr Lys Lys Lys Lys Asp Glu Leu Asp Pro Leu Leu Thr Arg 
        115                 120                 125             


Thr Gly Gly Ala Tyr Ile Pro Pro Ala Lys Leu Arg Met Met Gln Glu 
    130                 135                 140                 


Gln Ile Thr Asp Lys Asn Ser Leu Ala Tyr Gln Arg Met Ser Trp Glu 
145                 150                 155                 160 


Ala Leu Lys Lys Ser Ile Asn Gly Leu Ile Asn Lys Val Asn Ile Ser 
                165                 170                 175     


Asn Ile Ser Ile Ile Ile Gln Glu Leu Leu Gln Glu Asn Ile Val Arg 
            180                 185                 190         


Gly Arg Gly Leu Leu Ser Arg Ser Val Leu Gln Ala Gln Ser Ala Ser 
        195                 200                 205             


Pro Ile Phe Thr His Val Tyr Ala Ala Leu Val Ala Ile Ile Asn Ser 
    210                 215                 220                 


Lys Phe Pro Gln Ile Gly Glu Leu Ile Leu Lys Arg Leu Ile Leu Asn 
225                 230                 235                 240 


Phe Arg Lys Gly Tyr Arg Arg Asn Asp Lys Gln Leu Cys Leu Thr Ala 
                245                 250                 255     


Ser Lys Phe Val Ala His Leu Ile Asn Gln Asn Val Ala His Glu Val 
            260                 265                 270         


Leu Cys Leu Glu Met Leu Thr Leu Leu Leu Glu Arg Pro Thr Asp Asp 
        275                 280                 285             


Ser Val Glu Val Ala Ile Gly Phe Leu Lys Glu Cys Gly Leu Lys Leu 
    290                 295                 300                 


Thr Gln Val Ser Pro Arg Gly Ile Asn Ala Ile Phe Glu Arg Leu Arg 
305                 310                 315                 320 


Asn Ile Leu His Glu Ser Glu Ile Asp Lys Arg Val Gln Tyr Met Ile 
                325                 330                 335     


Glu Val Met Phe Ala Val Arg Lys Asp Gly Phe Lys Asp His Pro Ile 
            340                 345                 350         


Ile Leu Glu Gly Leu Asp Leu Val Glu Glu Asp Asp Gln Phe Thr His 
        355                 360                 365             


Met Leu Pro Leu Glu Asp Asp Tyr Asn Pro Glu Asp Val Leu Asn Val 
    370                 375                 380                 


Phe Lys Met Asp Pro Asn Phe Met Glu Asn Glu Glu Lys Tyr Lys Ala 
385                 390                 395                 400 


Ile Lys Lys Glu Ile Leu Asp Glu Gly Asp Thr Asp Ser Asn Thr Asp 
                405                 410                 415     


Gln Asp Ala Gly Ser Ser Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Gly Glu Glu Asp Glu Glu Gly Gln Lys Val Thr Ile His Asp Lys Thr 
        435                 440                 445             


Glu Ile Asn Leu Val Ser Phe Arg Arg Thr Ile Tyr Leu Ala Ile Gln 
    450                 455                 460                 


Ser Ser Leu Asp Phe Glu Glu Cys Ala His Lys Leu Leu Lys Met Glu 
465                 470                 475                 480 


Phe Pro Glu Ser Gln Thr Lys Glu Leu Cys Asn Met Ile Leu Asp Cys 
                485                 490                 495     


Cys Ala Gln Gln Arg Thr Tyr Glu Lys Phe Phe Gly Leu Leu Ala Gly 
            500                 505                 510         


Arg Phe Cys Met Leu Lys Lys Glu Tyr Met Glu Ser Phe Glu Gly Ile 
        515                 520                 525             


Phe Lys Glu Gln Tyr Asp Thr Ile His Arg Leu Glu Thr Asn Lys Leu 
    530                 535                 540                 


Arg Asn Val Ala Lys Met Phe Ala His Leu Leu Tyr Thr Asp Ser Leu 
545                 550                 555                 560 


Pro Trp Ser Val Leu Glu Cys Ile Lys Leu Ser Glu Glu Thr Thr Thr 
                565                 570                 575     


Ser Ser Ser Arg Ile Phe Val Lys Ile Phe Phe Gln Glu Leu Cys Glu 
            580                 585                 590         


Tyr Met Gly Leu Pro Lys Leu Asn Ala Arg Leu Lys Asp Glu Thr Leu 
        595                 600                 605             


Gln Pro Phe Phe Glu Gly Leu Leu Pro Arg Asp Asn Pro Arg Asn Thr 
    610                 615                 620                 


Arg Phe Ala Ile Asn Phe Phe Thr Ser Ile Gly Leu Gly Gly Leu Thr 
625                 630                 635                 640 


Asp Glu Leu Arg Glu His Leu Lys Asn Thr Pro Lys Val Ile Val Ala 
                645                 650                 655     


Gln Lys Pro Asp Val Glu Gln Asn Lys Ser Ser Pro Ser Ser Ser Ser 
            660                 665                 670         


Ser Ala Ser Ser Ser Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Asp 
        675                 680                 685             


Ser Ser Asp Ser Ser Ser Glu Ser Ser Ser Glu Glu Ser Asp Ser Ser 
    690                 695                 700                 


Ser Ile Ser Ser His Ser Ser Ala Ser Ala Asn Asp Val Arg Lys Lys 
705                 710                 715                 720 


Gly His Gly Lys Thr Arg Ser Lys Glu Val Asp Lys Leu Ile Arg Asn 
                725                 730                 735     


Gln Gln Thr Asn Asp Arg Lys Gln Lys Glu Arg Arg Gln Glu His Gly 
            740                 745                 750         


His Gln Glu Thr Arg Thr Glu Arg Glu Arg Arg Ser Glu Lys His Arg 
        755                 760                 765             


Asp Gln Asn Ser Ser Gly Ser Asn Trp Arg Asp Pro Ile Thr Lys Tyr 
    770                 775                 780                 


Thr Ser Asp Lys Asp Val Pro Ser Glu Arg Asn Asn Tyr Ser Arg Val 
785                 790                 795                 800 


Ala Asn Asp Arg Asp Gln Glu Met His Ile Asp Leu Glu Asn Lys His 
                805                 810                 815     


Gly Asp Pro Lys Lys Lys Arg Gly Glu Arg Arg Asn Ser Phe Ser Glu 
            820                 825                 830         


Asn Glu Lys His Thr His Arg Ile Lys Asp Ser Glu Asn Phe Arg Arg 
        835                 840                 845             


Lys Asp Arg Ser Lys Ser Lys Glu Met Asn Arg Lys His Ser Gly Ser 
    850                 855                 860                 


Arg Ser Asp Glu Asp Arg Tyr Gln Asn Gly Ala Glu Arg Arg Trp Glu 
865                 870                 875                 880 


Lys Ser Ser Arg Tyr Ser Glu Gln Ser Arg Glu Ser Lys Lys Asn Gln 
                885                 890                 895     


Asp Arg Arg Arg Glu Lys Ser Pro Ala Lys Gln Lys 
            900                 905             


<210>  56
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Lys Ile Ser Ser Pro Thr Glu Thr Glu Arg Cys Ile Glu Ser 
1               5                   10                  15      


Leu Ile Ala Val Phe Gln Lys Tyr Ala Gly Lys Asp Gly Tyr Asn Tyr 
            20                  25                  30          


Thr Leu Ser Lys Thr Glu Phe Leu Ser Phe Met Asn Thr Glu Leu Ala 
        35                  40                  45              


Ala Phe Thr Lys Asn Gln Lys Asp Pro Gly Val Leu Asp Arg Met Met 
    50                  55                  60                  


Lys Lys Leu Asp Thr Asn Ser Asp Gly Gln Leu Asp Phe Ser Glu Phe 
65                  70                  75                  80  


Leu Asn Leu Ile Gly Gly Leu Ala Met Ala Cys His Asp Ser Phe Leu 
                85                  90                  95      


Lys Ala Val Pro Ser Gln Lys Arg Thr 
            100                 105 


<210>  57
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Arg Arg Asp Asp Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Thr Asn Tyr Leu Ala Asp Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Thr Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210>  58
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ser Leu Val Ser Cys Leu Ser Glu Asp Leu Lys Val Leu Phe Phe 
1               5                   10                  15      


Arg Trp Gly Lys Ser Val Gly Ile Met Leu Thr Glu Leu Glu Lys Ala 
            20                  25                  30          


Leu Asn Ser Ile Ile Asp Val Tyr His Lys Tyr Ser Leu Ile Lys Gly 
        35                  40                  45              


Asn Phe His Ala Val Tyr Arg Asp Asp Leu Lys Lys Leu Leu Glu Thr 
    50                  55                  60                  


Glu Cys Pro Gln Tyr Ile Arg Lys Lys Gly Ala Asp Val Trp Phe Lys 
65                  70                  75                  80  


Glu Leu Asp Ile Asn Thr Asp Gly Ala Val Asn Phe Gln Glu Phe Leu 
                85                  90                  95      


Ile Leu Val Ile Lys Met Gly Val Ala Ala His Lys Lys Ser His Glu 
            100                 105                 110         


Glu Ser His Lys Glu 
        115         


<210>  59
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  60
<211>  2426
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Thr Asn Ile Glu Gln Ile Phe Arg Ser Phe Val Val Ser Lys 
1               5                   10                  15      


Phe Arg Glu Ile Gln Gln Glu Leu Ser Ser Gly Arg Asn Glu Gly Gln 
            20                  25                  30          


Leu Asn Gly Glu Thr Asn Thr Pro Ile Glu Gly Asn Gln Ala Gly Asp 
        35                  40                  45              


Ala Ala Ala Ser Ala Arg Ser Leu Pro Asn Glu Glu Ile Val Gln Lys 
    50                  55                  60                  


Ile Glu Glu Val Leu Ser Gly Val Leu Asp Thr Glu Leu Arg Tyr Lys 
65                  70                  75                  80  


Pro Asp Leu Lys Glu Gly Ser Arg Lys Ser Arg Cys Val Ser Val Gln 
                85                  90                  95      


Thr Asp Pro Thr Asp Glu Ile Pro Thr Lys Lys Ser Lys Lys His Lys 
            100                 105                 110         


Lys His Lys Asn Lys Lys Lys Lys Lys Lys Lys Glu Lys Glu Lys Lys 
        115                 120                 125             


Tyr Lys Arg Gln Pro Glu Glu Ser Glu Ser Lys Thr Lys Ser His Asp 
    130                 135                 140                 


Asp Gly Asn Ile Asp Leu Glu Ser Asp Ser Phe Leu Lys Phe Asp Ser 
145                 150                 155                 160 


Glu Pro Ser Ala Val Ala Leu Glu Leu Pro Thr Arg Ala Phe Gly Pro 
                165                 170                 175     


Ser Glu Thr Asn Glu Ser Pro Ala Val Val Leu Glu Pro Pro Val Val 
            180                 185                 190         


Ser Met Glu Val Ser Glu Pro His Ile Leu Glu Thr Leu Lys Pro Ala 
        195                 200                 205             


Thr Lys Thr Ala Glu Leu Ser Val Val Ser Thr Ser Val Ile Ser Glu 
    210                 215                 220                 


Gln Ser Glu Gln Ser Val Ala Val Met Pro Glu Pro Ser Met Thr Lys 
225                 230                 235                 240 


Ile Leu Asp Ser Phe Ala Ala Ala Pro Val Pro Thr Thr Thr Leu Val 
                245                 250                 255     


Leu Lys Ser Ser Glu Pro Val Val Thr Met Ser Val Glu Tyr Gln Met 
            260                 265                 270         


Lys Ser Val Leu Lys Ser Val Glu Ser Thr Ser Pro Glu Pro Ser Lys 
        275                 280                 285             


Ile Met Leu Val Glu Pro Pro Val Ala Lys Val Leu Glu Pro Ser Glu 
    290                 295                 300                 


Thr Leu Val Val Ser Ser Glu Thr Pro Thr Glu Val Tyr Pro Glu Pro 
305                 310                 315                 320 


Ser Thr Ser Thr Thr Met Asp Phe Pro Glu Ser Ser Ala Ile Glu Ala 
                325                 330                 335     


Leu Arg Leu Pro Glu Gln Pro Val Asp Val Pro Ser Glu Ile Ala Asp 
            340                 345                 350         


Ser Ser Met Thr Arg Pro Gln Glu Leu Pro Glu Leu Pro Lys Thr Thr 
        355                 360                 365             


Ala Leu Glu Leu Gln Glu Ser Ser Val Ala Ser Ala Met Glu Leu Pro 
    370                 375                 380                 


Gly Pro Pro Ala Thr Ser Met Pro Glu Leu Gln Gly Pro Pro Val Thr 
385                 390                 395                 400 


Pro Val Leu Glu Leu Pro Gly Pro Ser Ala Thr Pro Val Pro Glu Leu 
                405                 410                 415     


Pro Gly Pro Leu Ser Thr Pro Val Pro Glu Leu Pro Gly Pro Pro Ala 
            420                 425                 430         


Thr Ala Val Pro Glu Leu Pro Gly Pro Ser Val Thr Pro Val Pro Gln 
        435                 440                 445             


Leu Ser Gln Glu Leu Pro Gly Leu Pro Ala Pro Ser Met Gly Leu Glu 
    450                 455                 460                 


Pro Pro Gln Glu Val Pro Glu Pro Pro Val Met Ala Gln Glu Leu Pro 
465                 470                 475                 480 


Gly Leu Pro Leu Val Thr Ala Ala Val Glu Leu Pro Glu Gln Pro Ala 
                485                 490                 495     


Val Thr Val Ala Met Glu Leu Thr Glu Gln Pro Val Thr Thr Thr Glu 
            500                 505                 510         


Leu Glu Gln Pro Val Gly Met Thr Thr Val Glu His Pro Gly His Pro 
        515                 520                 525             


Glu Val Thr Thr Ala Thr Gly Leu Leu Gly Gln Pro Glu Ala Thr Met 
    530                 535                 540                 


Val Leu Glu Leu Pro Gly Gln Pro Val Ala Thr Thr Ala Leu Glu Leu 
545                 550                 555                 560 


Pro Gly Gln Pro Ser Val Thr Gly Val Pro Glu Leu Pro Gly Leu Pro 
                565                 570                 575     


Ser Ala Thr Arg Ala Leu Glu Leu Ser Gly Gln Pro Val Ala Thr Gly 
            580                 585                 590         


Ala Leu Glu Leu Pro Gly Pro Leu Met Ala Ala Gly Ala Leu Glu Phe 
        595                 600                 605             


Ser Gly Gln Ser Gly Ala Ala Gly Ala Leu Glu Leu Leu Gly Gln Pro 
    610                 615                 620                 


Leu Ala Thr Gly Val Leu Glu Leu Pro Gly Gln Pro Gly Ala Pro Glu 
625                 630                 635                 640 


Leu Pro Gly Gln Pro Val Ala Thr Val Ala Leu Glu Ile Ser Val Gln 
                645                 650                 655     


Ser Val Val Thr Thr Ser Glu Leu Ser Thr Met Thr Val Ser Gln Ser 
            660                 665                 670         


Leu Glu Val Pro Ser Thr Thr Ala Leu Glu Ser Tyr Asn Thr Val Ala 
        675                 680                 685             


Gln Glu Leu Pro Thr Thr Leu Val Gly Glu Thr Ser Val Thr Val Gly 
    690                 695                 700                 


Val Asp Pro Leu Met Ala Pro Glu Ser His Ile Leu Ala Ser Asn Thr 
705                 710                 715                 720 


Met Glu Thr His Ile Leu Ala Ser Asn Thr Met Asp Ser Gln Met Leu 
                725                 730                 735     


Ala Ser Asn Thr Met Asp Ser Gln Met Leu Ala Ser Asn Thr Met Asp 
            740                 745                 750         


Ser Gln Met Leu Ala Ser Ser Thr Met Asp Ser Gln Met Leu Ala Thr 
        755                 760                 765             


Ser Ser Met Asp Ser Gln Met Leu Ala Thr Ser Ser Met Asp Ser Gln 
    770                 775                 780                 


Met Leu Ala Thr Ser Thr Met Asp Ser Gln Met Leu Ala Thr Ser Ser 
785                 790                 795                 800 


Met Asp Ser Gln Met Leu Ala Thr Ser Ser Met Asp Ser Gln Met Leu 
                805                 810                 815     


Ala Thr Ser Ser Met Asp Ser Gln Met Leu Ala Thr Ser Ser Met Asp 
            820                 825                 830         


Ser Gln Met Leu Ala Thr Ser Thr Met Asp Ser Gln Met Leu Ala Thr 
        835                 840                 845             


Ser Thr Met Asp Ser Gln Met Leu Ala Thr Ser Ser Met Asp Ser Gln 
    850                 855                 860                 


Met Leu Ala Ser Gly Thr Met Asp Ser Gln Met Leu Ala Ser Gly Thr 
865                 870                 875                 880 


Met Asp Ala Gln Met Leu Ala Ser Gly Thr Met Asp Ala Gln Met Leu 
                885                 890                 895     


Ala Ser Ser Thr Gln Asp Ser Ala Met Leu Gly Ser Lys Ser Pro Asp 
            900                 905                 910         


Pro Tyr Arg Leu Ala Gln Asp Pro Tyr Arg Leu Ala Gln Asp Pro Tyr 
        915                 920                 925             


Arg Leu Gly His Asp Pro Tyr Arg Leu Gly His Asp Ala Tyr Arg Leu 
    930                 935                 940                 


Gly Gln Asp Pro Tyr Arg Leu Gly His Asp Pro Tyr Arg Leu Thr Pro 
945                 950                 955                 960 


Asp Pro Tyr Arg Met Ser Pro Arg Pro Tyr Arg Ile Ala Pro Arg Ser 
                965                 970                 975     


Tyr Arg Ile Ala Pro Arg Pro Tyr Arg Leu Ala Pro Arg Pro Leu Met 
            980                 985                 990         


Leu Ala Ser Arg Arg Ser Met Met  Met Ser Tyr Ala Ala  Glu Arg Ser 
        995                 1000                 1005             


Met Met  Ser Ser Tyr Glu Arg  Ser Met Met Ser Tyr  Glu Arg Ser 
    1010                 1015                 1020             


Met Met  Ser Pro Met Ala Glu  Arg Ser Met Met Ser  Ala Tyr Glu 
    1025                 1030                 1035             


Arg Ser  Met Met Ser Ala Tyr  Glu Arg Ser Met Met  Ser Pro Met 
    1040                 1045                 1050             


Ala Glu  Arg Ser Met Met Ser  Ala Tyr Glu Arg Ser  Met Met Ser 
    1055                 1060                 1065             


Ala Tyr  Glu Arg Ser Met Met  Ser Pro Met Ala Asp  Arg Ser Met 
    1070                 1075                 1080             


Met Ser  Met Gly Ala Asp Arg  Ser Met Met Ser Ser  Tyr Ser Ala 
    1085                 1090                 1095             


Ala Asp  Arg Ser Met Met Ser  Ser Tyr Ser Ala Ala  Asp Arg Ser 
    1100                 1105                 1110             


Met Met  Ser Ser Tyr Thr Ala  Asp Arg Ser Met Met  Ser Met Ala 
    1115                 1120                 1125             


Ala Asp  Ser Tyr Thr Asp Ser  Tyr Thr Asp Thr Tyr  Thr Glu Ala 
    1130                 1135                 1140             


Tyr Met  Val Pro Pro Leu Pro  Pro Glu Glu Pro Pro  Thr Met Pro 
    1145                 1150                 1155             


Pro Leu  Pro Pro Glu Glu Pro  Pro Met Thr Pro Pro  Leu Pro Pro 
    1160                 1165                 1170             


Glu Glu  Pro Pro Glu Gly Pro  Ala Leu Pro Thr Glu  Gln Ser Ala 
    1175                 1180                 1185             


Leu Thr  Ala Glu Asn Thr Trp  Pro Thr Glu Val Pro  Ser Leu Pro 
    1190                 1195                 1200             


Ser Glu  Glu Ser Val Ser Gln  Pro Glu Pro Pro Val  Ser Gln Ser 
    1205                 1210                 1215             


Glu Ile  Ser Glu Pro Ser Ala  Val Pro Thr Asp Tyr  Ser Val Ser 
    1220                 1225                 1230             


Ala Ser  Asp Pro Ser Val Leu  Val Ser Glu Ala Ala  Val Thr Val 
    1235                 1240                 1245             


Pro Glu  Pro Pro Pro Glu Pro  Glu Ser Ser Ile Thr  Leu Thr Pro 
    1250                 1255                 1260             


Val Glu  Ser Ala Val Val Ala  Glu Glu His Glu Val  Val Pro Glu 
    1265                 1270                 1275             


Arg Pro  Val Thr Cys Met Val  Ser Glu Thr Pro Ala  Met Ser Ala 
    1280                 1285                 1290             


Glu Pro  Thr Val Leu Ala Ser  Glu Pro Pro Val Met  Ser Glu Thr 
    1295                 1300                 1305             


Ala Glu  Thr Phe Asp Ser Met  Arg Ala Ser Gly His  Val Ala Ser 
    1310                 1315                 1320             


Glu Val  Ser Thr Ser Leu Leu  Val Pro Ala Val Thr  Thr Pro Val 
    1325                 1330                 1335             


Leu Ala  Glu Ser Ile Leu Glu  Pro Pro Ala Met Ala  Ala Pro Glu 
    1340                 1345                 1350             


Ser Ser  Ala Met Ala Val Leu  Glu Ser Ser Ala Val  Thr Val Leu 
    1355                 1360                 1365             


Glu Ser  Ser Thr Val Thr Val  Leu Glu Ser Ser Thr  Val Thr Val 
    1370                 1375                 1380             


Leu Glu  Pro Ser Val Val Thr  Val Pro Glu Pro Pro  Val Val Ala 
    1385                 1390                 1395             


Glu Pro  Asp Tyr Val Thr Ile  Pro Val Pro Val Val  Ser Ala Leu 
    1400                 1405                 1410             


Glu Pro  Ser Val Pro Val Leu  Glu Pro Ala Val Ser  Val Leu Gln 
    1415                 1420                 1425             


Pro Ser  Met Ile Val Ser Glu  Pro Ser Val Ser Val  Gln Glu Ser 
    1430                 1435                 1440             


Thr Val  Thr Val Ser Glu Pro  Ala Val Thr Val Ser  Glu Gln Thr 
    1445                 1450                 1455             


Gln Val  Ile Pro Thr Glu Val  Ala Ile Glu Ser Thr  Pro Met Ile 
    1460                 1465                 1470             


Leu Glu  Ser Ser Ile Met Ser  Ser His Val Met Lys  Gly Ile Asn 
    1475                 1480                 1485             


Leu Ser  Ser Gly Asp Gln Asn  Leu Ala Pro Glu Ile  Gly Met Gln 
    1490                 1495                 1500             


Glu Ile  Ala Leu His Ser Gly  Glu Glu Pro His Ala  Glu Glu His 
    1505                 1510                 1515             


Leu Lys  Gly Asp Phe Tyr Glu  Ser Glu His Gly Ile  Asn Ile Asp 
    1520                 1525                 1530             


Leu Asn  Ile Asn Asn His Leu  Ile Ala Lys Glu Met  Glu His Asn 
    1535                 1540                 1545             


Thr Val  Cys Ala Ala Gly Thr  Ser Pro Val Gly Glu  Ile Gly Glu 
    1550                 1555                 1560             


Glu Lys  Ile Leu Pro Thr Ser  Glu Thr Lys Gln Arg  Thr Val Leu 
    1565                 1570                 1575             


Asp Thr  Tyr Pro Gly Val Ser  Glu Ala Asp Ala Gly  Glu Thr Leu 
    1580                 1585                 1590             


Ser Ser  Thr Gly Pro Phe Ala  Leu Glu Pro Asp Ala  Thr Gly Thr 
    1595                 1600                 1605             


Ser Lys  Gly Ile Glu Phe Thr  Thr Ala Ser Thr Leu  Ser Leu Val 
    1610                 1615                 1620             


Asn Lys  Tyr Asp Val Asp Leu  Ser Leu Thr Thr Gln  Asp Thr Glu 
    1625                 1630                 1635             


His Asp  Met Val Ile Ser Thr  Ser Pro Ser Gly Gly  Ser Glu Ala 
    1640                 1645                 1650             


Asp Ile  Glu Gly Pro Leu Pro  Ala Lys Asp Ile His  Leu Asp Leu 
    1655                 1660                 1665             


Pro Ser  Asn Asn Asn Leu Val  Ser Lys Asp Thr Glu  Glu Pro Leu 
    1670                 1675                 1680             


Pro Val  Lys Glu Ser Asp Gln  Thr Leu Ala Ala Leu  Leu Ser Pro 
    1685                 1690                 1695             


Lys Glu  Ser Ser Gly Gly Glu  Lys Glu Val Pro Pro  Pro Pro Lys 
    1700                 1705                 1710             


Glu Thr  Leu Pro Asp Ser Gly  Phe Ser Ala Asn Ile  Glu Asp Ile 
    1715                 1720                 1725             


Asn Glu  Ala Asp Leu Val Arg  Pro Leu Leu Pro Lys  Asp Met Glu 
    1730                 1735                 1740             


Arg Leu  Thr Ser Leu Arg Ala  Gly Ile Glu Gly Pro  Leu Leu Ala 
    1745                 1750                 1755             


Ser Asp  Val Gly Arg Asp Arg  Ser Ala Ala Ser Pro  Val Val Ser 
    1760                 1765                 1770             


Ser Met  Pro Glu Arg Ala Ser  Glu Ser Ser Ser Glu  Glu Lys Asp 
    1775                 1780                 1785             


Asp Tyr  Glu Ile Phe Val Lys  Val Lys Asp Thr His  Glu Lys Ser 
    1790                 1795                 1800             


Lys Lys  Asn Lys Asn Arg Asp  Lys Gly Glu Lys Glu  Lys Lys Arg 
    1805                 1810                 1815             


Asp Ser  Ser Leu Arg Ser Arg  Ser Lys Arg Ser Lys  Ser Ser Glu 
    1820                 1825                 1830             


His Lys  Ser Arg Lys Arg Thr  Ser Glu Ser Arg Ser  Arg Ala Arg 
    1835                 1840                 1845             


Lys Arg  Ser Ser Lys Ser Lys  Ser His Arg Ser Gln  Thr Arg Ser 
    1850                 1855                 1860             


Arg Ser  Arg Ser Arg Arg Arg  Arg Arg Ser Ser Arg  Ser Arg Ser 
    1865                 1870                 1875             


Lys Ser  Arg Gly Arg Arg Ser  Val Ser Lys Glu Lys  Arg Lys Arg 
    1880                 1885                 1890             


Ser Pro  Lys His Arg Ser Lys  Ser Arg Glu Arg Lys  Arg Lys Arg 
    1895                 1900                 1905             


Ser Ser  Ser Arg Asp Asn Arg  Lys Thr Val Arg Ala  Arg Ser Arg 
    1910                 1915                 1920             


Thr Pro  Ser Arg Arg Ser Arg  Ser His Thr Pro Ser  Arg Arg Arg 
    1925                 1930                 1935             


Arg Ser  Arg Ser Val Gly Arg  Arg Arg Ser Phe Ser  Ile Ser Pro 
    1940                 1945                 1950             


Ser Arg  Arg Ser Arg Thr Pro  Ser Arg Arg Ser Arg  Thr Pro Ser 
    1955                 1960                 1965             


Arg Arg  Ser Arg Thr Pro Ser  Arg Arg Ser Arg Thr  Pro Ser Arg 
    1970                 1975                 1980             


Arg Ser  Arg Thr Pro Ser Arg  Arg Ser Arg Thr Pro  Ser Arg Arg 
    1985                 1990                 1995             


Arg Arg  Ser Arg Ser Val Val  Arg Arg Arg Ser Phe  Ser Ile Ser 
    2000                 2005                 2010             


Pro Val  Arg Leu Arg Arg Ser  Arg Thr Pro Leu Arg  Arg Arg Phe 
    2015                 2020                 2025             


Ser Arg  Ser Pro Ile Arg Arg  Lys Arg Ser Arg Ser  Ser Glu Arg 
    2030                 2035                 2040             


Gly Arg  Ser Pro Lys Arg Leu  Thr Asp Leu Asp Lys  Ala Gln Leu 
    2045                 2050                 2055             


Leu Glu  Ile Ala Lys Ala Asn  Ala Ala Ala Met Cys  Ala Lys Ala 
    2060                 2065                 2070             


Gly Val  Pro Leu Pro Pro Asn  Leu Lys Pro Ala Pro  Pro Pro Thr 
    2075                 2080                 2085             


Ile Glu  Glu Lys Val Ala Lys  Lys Ser Gly Gly Ala  Thr Ile Glu 
    2090                 2095                 2100             


Glu Leu  Thr Glu Lys Cys Lys  Gln Ile Ala Gln Ser  Lys Glu Asp 
    2105                 2110                 2115             


Asp Asp  Val Ile Val Asn Lys  Pro His Val Ser Asp  Glu Glu Glu 
    2120                 2125                 2130             


Glu Glu  Pro Pro Phe Tyr His  His Pro Phe Lys Leu  Ser Glu Pro 
    2135                 2140                 2145             


Lys Pro  Ile Phe Phe Asn Leu  Asn Ile Ala Ala Ala  Lys Pro Thr 
    2150                 2155                 2160             


Pro Pro  Lys Ser Gln Val Thr  Leu Thr Lys Glu Phe  Pro Val Ser 
    2165                 2170                 2175             


Ser Gly  Ser Gln His Arg Lys  Lys Glu Ala Asp Ser  Val Tyr Gly 
    2180                 2185                 2190             


Glu Trp  Val Pro Val Glu Lys  Asn Gly Glu Glu Asn  Lys Asp Asp 
    2195                 2200                 2205             


Asp Asn  Val Phe Ser Ser Asn  Leu Pro Ser Glu Pro  Val Asp Ile 
    2210                 2215                 2220             


Ser Thr  Ala Met Ser Glu Arg  Ala Leu Ala Gln Lys  Arg Leu Ser 
    2225                 2230                 2235             


Glu Asn  Ala Phe Asp Leu Glu  Ala Met Ser Met Leu  Asn Arg Ala 
    2240                 2245                 2250             


Gln Glu  Arg Ile Asp Ala Trp  Ala Gln Leu Asn Ser  Ile Pro Gly 
    2255                 2260                 2265             


Gln Phe  Thr Gly Ser Thr Gly  Val Gln Val Leu Thr  Gln Glu Gln 
    2270                 2275                 2280             


Leu Ala  Asn Thr Gly Ala Gln  Ala Trp Ile Lys Lys  Asp Gln Phe 
    2285                 2290                 2295             


Leu Arg  Ala Ala Pro Val Thr  Gly Gly Met Gly Ala  Val Leu Met 
    2300                 2305                 2310             


Arg Lys  Met Gly Trp Arg Glu  Gly Glu Gly Leu Gly  Lys Asn Lys 
    2315                 2320                 2325             


Glu Gly  Asn Lys Glu Pro Ile  Leu Val Asp Phe Lys  Thr Asp Arg 
    2330                 2335                 2340             


Lys Gly  Leu Val Ala Val Gly  Glu Arg Ala Gln Lys  Arg Ser Gly 
    2345                 2350                 2355             


Asn Phe  Ser Ala Ala Met Lys  Asp Leu Ser Gly Lys  His Pro Val 
    2360                 2365                 2370             


Ser Ala  Leu Met Glu Ile Cys  Asn Lys Arg Arg Trp  Gln Pro Pro 
    2375                 2380                 2385             


Glu Phe  Leu Leu Val His Asp  Ser Gly Pro Asp His  Arg Lys His 
    2390                 2395                 2400             


Phe Leu  Phe Arg Val Leu Arg  Asn Gly Ala Leu Thr  Arg Pro Asn 
    2405                 2410                 2415             


Cys Met  Phe Phe Leu Asn Arg  Tyr 
    2420                 2425     


<210>  61
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Val Gly Lys Leu Lys Gln Asn Leu Leu Leu Ala Cys Leu Val Ile 
1               5                   10                  15      


Ser Ser Val Thr Val Phe Tyr Leu Gly Gln His Ala Met Glu Cys His 
            20                  25                  30          


His Arg Ile Glu Glu Arg Ser Gln Pro Val Lys Leu Glu Ser Thr Arg 
        35                  40                  45              


Thr Thr Val Arg Thr Gly Leu Asp Leu Lys Ala Asn Lys Thr Phe Ala 
    50                  55                  60                  


Tyr His Lys Asp Met Pro Leu Ile Phe Ile Gly Gly Val Pro Arg Ser 
65                  70                  75                  80  


Gly Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Asp Ile Arg 
                85                  90                  95      


Cys Gly Glu Glu Thr Arg Val Ile Pro Arg Ile Leu Ala Leu Lys Gln 
            100                 105                 110         


Met Trp Ser Arg Ser Ser Lys Glu Lys Ile Arg Leu Asp Glu Ala Gly 
        115                 120                 125             


Val Thr Asp Glu Val Leu Asp Ser Ala Met Gln Ala Phe Leu Leu Glu 
    130                 135                 140                 


Ile Ile Val Lys His Gly Glu Pro Ala Pro Tyr Leu Cys Asn Lys Asp 
145                 150                 155                 160 


Pro Phe Ala Leu Lys Ser Leu Thr Tyr Leu Ser Arg Leu Phe Pro Asn 
                165                 170                 175     


Ala Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser 
            180                 185                 190         


Met Ile Ser Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Asn Ser Tyr 
        195                 200                 205             


Arg Asp Cys Leu Thr Lys Trp Asn Arg Ala Ile Glu Thr Met Tyr Asn 
    210                 215                 220                 


Gln Cys Met Glu Val Gly Tyr Lys Lys Cys Met Leu Val His Tyr Glu 
225                 230                 235                 240 


Gln Leu Val Leu His Pro Glu Arg Trp Met Arg Thr Leu Leu Lys Phe 
                245                 250                 255     


Leu Gln Ile Pro Trp Asn His Ser Val Leu His His Glu Glu Met Ile 
            260                 265                 270         


Gly Lys Ala Gly Gly Val Ser Leu Ser Lys Val Glu Arg Ser Thr Asp 
        275                 280                 285             


Gln Val Ile Lys Pro Val Asn Val Gly Ala Leu Ser Lys Trp Val Gly 
    290                 295                 300                 


Lys Ile Pro Pro Asp Val Leu Gln Asp Met Ala Val Ile Ala Pro Met 
305                 310                 315                 320 


Leu Ala Lys Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly 
                325                 330                 335     


Lys Pro Asp Pro Lys Ile Ile Glu Asn Thr Arg Arg Val Tyr Lys Gly 
            340                 345                 350         


Glu Phe Gln Leu Pro Asp Phe Leu Lys Glu Lys Pro Gln Thr Glu Gln 
        355                 360                 365             


Val Glu 
    370 


<210>  62
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Glu Thr Leu Ser Gly Leu Gly Asp Ser Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ala Ala Leu Ser Ser Ala Ser Ser Glu Thr Gly Thr Arg Arg Leu Ser 
            20                  25                  30          


Asp Leu Arg Val Ile Asp Leu Arg Ala Glu Leu Arg Lys Arg Asn Val 
        35                  40                  45              


Asp Ser Ser Gly Asn Lys Ser Val Leu Met Glu Arg Leu Lys Lys Ala 
    50                  55                  60                  


Ile Glu Asp Glu Gly Gly Asn Pro Asp Glu Ile Glu Ile Thr Ser Glu 
65                  70                  75                  80  


Gly Asn Lys Lys Thr Ser Lys Arg Ser Ser Lys Gly Arg Lys Pro Glu 
                85                  90                  95      


Glu Glu Gly Val Glu Asp Asn Gly Leu Glu Glu Asn Ser Gly Asp Gly 
            100                 105                 110         


Gln Glu Asp Val Glu Thr Ser Leu Glu Asn Leu Gln Asp Ile Asp Ile 
        115                 120                 125             


Met Asp Ile Ser Val Leu Asp Glu Ala Glu Ile Asp Asn Gly Ser Val 
    130                 135                 140                 


Ala Asp Cys Val Glu Asp Asp Asp Ala Asp Asn Leu Gln Glu Ser Leu 
145                 150                 155                 160 


Ser Asp Ser Arg Glu Leu Val Glu Gly Glu Met Lys Glu Leu Pro Glu 
                165                 170                 175     


Gln Leu Gln Glu His Ala Ile Glu Asp Lys Glu Thr Ile Asn Asn Leu 
            180                 185                 190         


Asp Thr Ser Ser Ser Asp Phe Thr Ile Leu Gln Glu Ile Glu Glu Pro 
        195                 200                 205             


Ser Leu Glu Pro Glu Asn Glu Lys Ile Leu Asp Ile Leu Gly Glu Thr 
    210                 215                 220                 


Cys Lys Ser Glu Pro Val Lys Glu Glu Ser Ser Glu Leu Glu Gln Pro 
225                 230                 235                 240 


Phe Ala Gln Asp Thr Ser Ser Val Gly Pro Asp Arg Lys Leu Ala Glu 
                245                 250                 255     


Glu Glu Asp Leu Phe Asp Ser Ala His Pro Glu Glu Gly Asp Leu Asp 
            260                 265                 270         


Leu Ala Ser Glu Ser Thr Ala His Ala Gln Ser Ser Lys Ala Asp Ser 
        275                 280                 285             


Leu Leu Ala Val Val Lys Arg Glu Pro Ala Glu Gln Pro Gly Asp Gly 
    290                 295                 300                 


Glu Arg Thr Asp Cys Glu Pro Val Gly Leu Glu Pro Ala Val Glu Gln 
305                 310                 315                 320 


Ser Ser Ala Ala Ser Glu Leu Ala Glu Ala Ser Ser Glu Glu Leu Ala 
                325                 330                 335     


Glu Ala Pro Thr Glu Ala Pro Ser Pro Glu Ala Arg Asp Ser Lys Glu 
            340                 345                 350         


Asp Gly Arg Lys Phe Asp Phe Asp Ala Cys Asn Glu Val Pro Pro Ala 
        355                 360                 365             


Pro Lys Glu Ser Ser Thr Ser Glu Gly Ala Asp Gln Lys Met Ser Ser 
    370                 375                 380                 


Pro Glu Asp Asp Ser Asp Thr Lys Arg Leu Ser Lys Glu Glu Lys Gly 
385                 390                 395                 400 


Arg Ser Ser Cys Gly Arg Asn Phe Trp Val Ser Gly Leu Ser Ser Thr 
                405                 410                 415     


Thr Arg Ala Thr Asp Leu Lys Asn Leu Phe Ser Lys Tyr Gly Lys Val 
            420                 425                 430         


Val Gly Ala Lys Val Val Thr Asn Ala Arg Ser Pro Gly Ala Arg Cys 
        435                 440                 445             


Tyr Gly Phe Val Thr Met Ser Thr Ala Glu Glu Ala Thr Lys Cys Ile 
    450                 455                 460                 


Asn His Leu His Lys Thr Glu Leu His Gly Lys Met Ile Ser Val Glu 
465                 470                 475                 480 


Lys Ala Lys Asn Glu Pro Val Gly Lys Lys Thr Ser Asp Lys Arg Asp 
                485                 490                 495     


Ser Asp Gly Lys Lys Glu Lys Ser Ser Asn Ser Asp Arg Ser Thr Asn 
            500                 505                 510         


Leu Lys Arg Asp Asp Lys Cys Asp Arg Lys Asp Asp Ala Lys Lys Gly 
        515                 520                 525             


Asp Asp Gly Ser Gly Glu Lys Ser Lys Asp Gln Asp Asp Gln Lys Pro 
    530                 535                 540                 


Gly Pro Ser Glu Arg Ser Arg Ala Thr Lys Ser Gly Ser Arg Gly Thr 
545                 550                 555                 560 


Glu Arg Thr Val Val Met Asp Lys Ser Lys Gly Val Pro Val Ile Ser 
                565                 570                 575     


Val Lys Thr Ser Gly Ser Lys Glu Arg Ala Ser Lys Ser Gln Asp Arg 
            580                 585                 590         


Lys Ser Ala Ser Arg Glu Lys Arg Ser Val Val Ser Phe Asp Lys Val 
        595                 600                 605             


Lys Glu Pro Arg Lys Ser Arg Asp Ser Glu Ser His Ser Arg Val Arg 
    610                 615                 620                 


Glu Arg Ser Glu Arg Glu Gln Arg Met Gln Ala Gln Trp Glu Arg Glu 
625                 630                 635                 640 


Glu Arg Glu Arg Leu Glu Ile Ala Arg Glu Arg Leu Ala Phe Gln Arg 
                645                 650                 655     


Gln Arg Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu Arg Glu 
            660                 665                 670         


Arg Met His Val Glu His Glu Arg Arg Arg Glu Gln Glu Arg Ile His 
        675                 680                 685             


Arg Glu Arg Glu Glu Leu Arg Arg Gln Gln Glu Leu Arg Tyr Glu Gln 
    690                 695                 700                 


Glu Arg Arg Pro Ala Val Arg Arg Pro Tyr Asp Leu Asp Arg Arg Asp 
705                 710                 715                 720 


Asp Ala Tyr Trp Pro Glu Ala Lys Arg Ala Ala Leu Asp Glu Arg Tyr 
                725                 730                 735     


His Ser Asp Phe Asn Arg Gln Asp Arg Phe His Asp Phe Asp His Arg 
            740                 745                 750         


Asp Arg Gly Arg Tyr Pro Asp His Ser Val Asp Arg Arg Glu Gly Ser 
        755                 760                 765             


Arg Ser Met Met Gly Glu Arg Glu Gly Gln His Tyr Pro Glu Arg His 
    770                 775                 780                 


Gly Gly Pro Glu Arg His Gly Arg Asp Ser Arg Asp Gly Trp Gly Gly 
785                 790                 795                 800 


Tyr Gly Ser Asp Lys Arg Met Ser Glu Gly Arg Gly Leu Pro Pro Pro 
                805                 810                 815     


Pro Arg Gly Arg Arg Asp Trp Gly Asp His Gly Arg Arg Glu Asp Asp 
            820                 825                 830         


Arg Ser Trp Gln Gly Thr Ala Asp Gly Gly Met Met Asp Arg Asp His 
        835                 840                 845             


Lys Arg Trp Gln Gly Gly Glu Arg Ser Met Ser Gly His Ser Gly Pro 
    850                 855                 860                 


Gly His Met Met Asn Arg Gly Gly Met Ser Gly Arg Gly Ser Phe Ala 
865                 870                 875                 880 


Pro Gly Gly Ala Ser Arg Gly His Pro Ile Pro His Gly Gly Met Gln 
                885                 890                 895     


Gly Gly Phe Gly Gly Gln Ser Arg Gly Ser Arg Pro Ser Asp Ala Arg 
            900                 905                 910         


Phe Thr Arg Arg Tyr 
        915         


<210>  63
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Gly Asn Tyr Lys Ser Arg Pro Thr Gln Thr Cys Thr Asp Glu Trp 
1               5                   10                  15      


Lys Lys Lys Val Ser Glu Ser Tyr Val Ile Thr Ile Glu Arg Leu Glu 
            20                  25                  30          


Asp Asp Leu Gln Ile Lys Glu Lys Glu Leu Thr Glu Leu Arg Asn Ile 
        35                  40                  45              


Phe Gly Ser Asp Glu Ala Phe Ser Lys Val Asn Leu Asn Tyr Arg Thr 
    50                  55                  60                  


Glu Asn Gly Leu Ser Leu Leu His Leu Cys Cys Ile Cys Gly Gly Lys 
65                  70                  75                  80  


Lys Ser His Ile Arg Thr Leu Met Leu Lys Gly Leu Arg Pro Ser Arg 
                85                  90                  95      


Leu Thr Arg Asn Gly Phe Thr Ala Leu His Leu Ala Val Tyr Lys Asp 
            100                 105                 110         


Asn Ala Glu Leu Ile Thr Ser Leu Leu His Ser Gly Ala Asp Ile Gln 
        115                 120                 125             


Gln Val Gly Tyr Gly Gly Leu Thr Ala Leu His Ile Ala Thr Ile Ala 
    130                 135                 140                 


Gly His Leu Glu Ala Ala Asp Val Leu Leu Gln His Gly Ala Asn Val 
145                 150                 155                 160 


Asn Ile Gln Asp Ala Val Phe Phe Thr Pro Leu His Ile Ala Ala Tyr 
                165                 170                 175     


Tyr Gly His Glu Gln Val Thr Arg Leu Leu Leu Lys Phe Gly Ala Asp 
            180                 185                 190         


Val Asn Val Ser Gly Glu Val Gly Asp Arg Pro Leu His Leu Ala Ser 
        195                 200                 205             


Ala Lys Gly Phe Leu Asn Ile Ala Lys Leu Leu Met Glu Glu Gly Ser 
    210                 215                 220                 


Lys Ala Asp Val Asn Ala Gln Asp Asn Glu Asp His Val Pro Leu His 
225                 230                 235                 240 


Phe Cys Ser Arg Phe Gly His His Asp Ile Val Lys Tyr Leu Leu Gln 
                245                 250                 255     


Ser Asp Leu Glu Val Gln Pro His Val Val Asn Ile Tyr Gly Asp Thr 
            260                 265                 270         


Pro Leu His Leu Ala Cys Tyr Asn Gly Lys Phe Glu Val Ala Lys Glu 
        275                 280                 285             


Ile Ile Gln Ile Ser Gly Thr Glu Ser Leu Thr Lys Glu Asn Ile Phe 
    290                 295                 300                 


Ser Glu Thr Ala Phe His Ser Ala Cys Thr Tyr Gly Lys Ser Ile Asp 
305                 310                 315                 320 


Leu Val Lys Phe Leu Leu Asp Gln Asn Val Ile Asn Ile Asn His Gln 
                325                 330                 335     


Gly Arg Asp Gly His Thr Gly Leu His Ser Ala Cys Tyr His Gly His 
            340                 345                 350         


Ile Arg Leu Val Gln Phe Leu Leu Asp Asn Gly Ala Asp Met Asn Leu 
        355                 360                 365             


Val Ala Cys Asp Pro Ser Arg Ser Ser Gly Glu Lys Asp Glu Gln Thr 
    370                 375                 380                 


Cys Leu Met Trp Ala Tyr Glu Lys Gly His Asp Ala Ile Val Thr Leu 
385                 390                 395                 400 


Leu Lys His Tyr Lys Arg Pro Gln Asp Glu Leu Pro Cys Asn Glu Tyr 
                405                 410                 415     


Ser Gln Pro Gly Gly Asp Gly Ser Tyr Val Ser Val Pro Ser Pro Leu 
            420                 425                 430         


Gly Lys Ile Lys Ser Met Thr Lys Glu Lys Ala Asp Ile Leu Leu Leu 
        435                 440                 445             


Arg Ala Gly Leu Pro Ser His Phe His Leu Gln Leu Ser Glu Ile Glu 
    450                 455                 460                 


Phe His Glu Ile Ile Gly Ser Gly Ser Phe Gly Lys Val Tyr Lys Gly 
465                 470                 475                 480 


Arg Cys Arg Asn Lys Ile Val Ala Ile Lys Arg Tyr Arg Ala Asn Thr 
                485                 490                 495     


Tyr Cys Ser Lys Ser Asp Val Asp Met Phe Cys Arg Glu Val Ser Ile 
            500                 505                 510         


Leu Cys Gln Leu Asn His Pro Cys Val Ile Gln Phe Val Gly Ala Cys 
        515                 520                 525             


Leu Asn Asp Pro Ser Gln Phe Ala Ile Val Thr Gln Tyr Ile Ser Gly 
    530                 535                 540                 


Gly Ser Leu Phe Ser Leu Leu His Glu Gln Lys Arg Ile Leu Asp Leu 
545                 550                 555                 560 


Gln Ser Lys Leu Ile Ile Ala Val Asp Val Ala Lys Gly Met Glu Tyr 
                565                 570                 575     


Leu His Asn Leu Thr Gln Pro Ile Ile His Arg Asp Leu Asn Ser His 
            580                 585                 590         


Asn Ile Leu Leu Tyr Glu Asp Gly His Ala Val Val Ala Asp Phe Gly 
        595                 600                 605             


Glu Ser Arg Phe Leu Gln Ser Leu Asp Glu Asp Asn Met Thr Lys Gln 
    610                 615                 620                 


Pro Gly Asn Leu Arg Trp Met Ala Pro Glu Val Phe Thr Gln Cys Thr 
625                 630                 635                 640 


Arg Tyr Thr Ile Lys Ala Asp Val Phe Ser Tyr Ala Leu Cys Leu Trp 
                645                 650                 655     


Glu Ile Leu Thr Gly Glu Ile Pro Phe Ala His Leu Lys Pro Ala Ala 
            660                 665                 670         


Ala Ala Ala Asp Met Ala Tyr His His Ile Arg Pro Pro Ile Gly Tyr 
        675                 680                 685             


Ser Ile Pro Lys Pro Ile Ser Ser Leu Leu Ile Arg Gly Trp Asn Ala 
    690                 695                 700                 


Cys Pro Glu Gly Arg Pro Glu Phe Ser Glu Val Val Met Lys Leu Glu 
705                 710                 715                 720 


Glu Cys Leu Cys Asn Ile Glu Leu Met Ser Pro Ala Ser Ser Asn Ser 
                725                 730                 735     


Ser Gly Ser Leu Ser Pro Ser Ser Ser Ser Asp Cys Leu Val Asn Arg 
            740                 745                 750         


Gly Gly Pro Gly Arg Ser His Val Ala Ala Leu Arg Ser Arg Phe Glu 
        755                 760                 765             


Leu Glu Tyr Ala Leu Asn Ala Arg Ser Tyr Ala Ala Leu Ser Gln Ser 
    770                 775                 780                 


Ala Gly Gln Tyr Ser Ser Gln Gly Leu Ser Leu Glu Glu Met Lys Arg 
785                 790                 795                 800 


Ser Leu Gln Tyr Thr Pro Ile Asp Lys Tyr Gly Tyr Val Ser Asp Pro 
                805                 810                 815     


Met Ser Ser Met His Phe His Ser Cys Arg Asn Ser Ser Ser Phe Glu 
            820                 825                 830         


Asp Ser Ser 
        835 


<210>  64
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe 
1               5                   10                  15      


Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro 
            20                  25                  30          


Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser 
        35                  40                  45              


Asp Ser Ala His Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser 
    50                  55                  60                  


Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln 
65                  70                  75                  80  


Lys Val Leu Ala Asp Ser Ser Leu Glu Gly Gln Lys Lys Thr Thr Glu 
                85                  90                  95      


Pro Leu Asp Gln Gln Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val 
            100                 105                 110         


Ser Cys Tyr Phe Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr 
        115                 120                 125             


Asp Tyr Thr Leu Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe 
    130                 135                 140                 


Pro Ile Cys Gln Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr 
145                 150                 155                 160 


Thr Ile Glu Ser Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln 
                165                 170                 175     


Glu Ile Asn Phe Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu 
            180                 185                 190         


Leu Phe Ser Lys Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val 
        195                 200                 205             


Asn Ala Val Tyr Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu 
    210                 215                 220                 


Asn Thr Val Asp Ala Pro Phe Cys Leu Asn Ala Asn Glu Asn Lys Ser 
225                 230                 235                 240 


Val Lys Met Met Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu 
                245                 250                 255     


Glu Val Lys Ala Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu 
            260                 265                 270         


Ser Met Phe Val Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly 
        275                 280                 285             


Leu Glu Glu Leu Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp 
    290                 295                 300                 


Ser Ser Ser Glu Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro 
305                 310                 315                 320 


Arg Phe Thr Leu Glu Asp Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp 
                325                 330                 335     


Met Gly Ile Thr Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly 
            340                 345                 350         


Ile Ser Pro Ser Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr 
        355                 360                 365             


Phe Val Glu Val Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly 
    370                 375                 380                 


Ala Val Val Ser Glu Arg Ser Leu Arg Ser Trp Val Glu Phe Asn Ala 
385                 390                 395                 400 


Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile 
                405                 410                 415     


Leu Phe Tyr Gly Arg Val Cys Ser Pro 
            420                 425 


<210>  65
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe 
1               5                   10                  15      


Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile 
            20                  25                  30          


Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn 
        35                  40                  45              


Thr Ala Gln Gln Ile Lys Lys Val Leu His Phe Asp Gln Val Thr Glu 
    50                  55                  60                  


Asn Thr Thr Gly Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn 
65                  70                  75                  80  


Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr 
                85                  90                  95      


Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr 
            100                 105                 110         


Tyr Leu Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln 
        115                 120                 125             


Thr Ser Val Glu Ser Val Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg 
    130                 135                 140                 


Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys 
145                 150                 155                 160 


Asn Leu Ile Pro Glu Gly Asn Ile Gly Ser Asn Thr Thr Leu Val Leu 
                165                 170                 175     


Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Lys Lys Phe Asn Lys 
            180                 185                 190         


Glu Asp Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Asn Thr Tyr Lys 
        195                 200                 205             


Ser Ile Gln Met Met Arg Gln Tyr Thr Ser Phe His Phe Ala Ser Leu 
    210                 215                 220                 


Glu Asp Val Gln Ala Lys Val Leu Glu Ile Pro Tyr Lys Gly Lys Asp 
225                 230                 235                 240 


Leu Ser Met Ile Val Leu Leu Pro Asn Glu Ile Asp Gly Leu Gln Lys 
                245                 250                 255     


Leu Glu Glu Lys Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu 
            260                 265                 270         


Gln Asn Met Arg Glu Thr Arg Val Asp Leu His Leu Pro Arg Phe Lys 
        275                 280                 285             


Val Glu Glu Ser Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met 
    290                 295                 300                 


Val Asp Ile Phe Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Gly Ser 
305                 310                 315                 320 


Arg Gly Leu Val Leu Ser Gly Val Leu His Lys Ala Phe Val Glu Val 
                325                 330                 335     


Thr Glu Glu Gly Ala Glu Ala Ala Ala Ala Thr Ala Val Val Gly Phe 
            340                 345                 350         


Gly Ser Ser Pro Thr Ser Thr Asn Glu Glu Phe His Cys Asn His Pro 
        355                 360                 365             


Phe Leu Phe Phe Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr 
    370                 375                 380                 


Gly Arg Phe Ser Ser Pro 
385                 390 


<210>  66
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe 
1               5                   10                  15      


Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile 
            20                  25                  30          


Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn 
        35                  40                  45              


Thr Ala Gln Gln Ile Ser Lys Val Leu His Phe Asp Gln Val Thr Glu 
    50                  55                  60                  


Asn Thr Thr Glu Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn 
65                  70                  75                  80  


Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr 
                85                  90                  95      


Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr 
            100                 105                 110         


Tyr Gln Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln 
        115                 120                 125             


Thr Ser Val Glu Ser Thr Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg 
    130                 135                 140                 


Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys 
145                 150                 155                 160 


Asn Leu Phe Pro Asp Gly Thr Ile Gly Asn Asp Thr Thr Leu Val Leu 
                165                 170                 175     


Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Asn Lys Phe Lys Lys 
            180                 185                 190         


Glu Asn Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Asn Thr Tyr Lys 
        195                 200                 205             


Ser Val Gln Met Met Arg Gln Tyr Asn Ser Phe Asn Phe Ala Leu Leu 
    210                 215                 220                 


Glu Asp Val Gln Ala Lys Val Leu Glu Ile Pro Tyr Lys Gly Lys Asp 
225                 230                 235                 240 


Leu Ser Met Ile Val Leu Leu Pro Asn Glu Ile Asp Gly Leu Gln Lys 
                245                 250                 255     


Leu Glu Glu Lys Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu 
            260                 265                 270         


Gln Asn Met Arg Glu Thr Cys Val Asp Leu His Leu Pro Arg Phe Lys 
        275                 280                 285             


Met Glu Glu Ser Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met 
    290                 295                 300                 


Val Asn Ile Phe Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Trp Ser 
305                 310                 315                 320 


His Gly Leu Ser Val Ser Lys Val Leu His Lys Ala Phe Val Glu Val 
                325                 330                 335     


Thr Glu Glu Gly Val Glu Ala Ala Ala Ala Thr Ala Val Val Val Val 
            340                 345                 350         


Glu Leu Ser Ser Pro Ser Thr Asn Glu Glu Phe Cys Cys Asn His Pro 
        355                 360                 365             


Phe Leu Phe Phe Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr 
    370                 375                 380                 


Gly Arg Phe Ser Ser Pro 
385                 390 


<210>  67
<211>  1085
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ser Thr Pro Ser Arg Phe Lys Lys Asp Lys Glu Ile Ile Ala Glu 
1               5                   10                  15      


Tyr Glu Ser Gln Val Lys Glu Ile Arg Ala Gln Leu Val Glu Gln Gln 
            20                  25                  30          


Lys Cys Leu Glu Gln Gln Thr Glu Met Arg Val Gln Leu Leu Gln Asp 
        35                  40                  45              


Leu Gln Asp Phe Phe Arg Lys Lys Ala Glu Ile Glu Thr Glu Tyr Ser 
    50                  55                  60                  


Arg Asn Leu Glu Lys Leu Ala Glu Arg Phe Met Ala Lys Thr Arg Ser 
65                  70                  75                  80  


Thr Lys Asp His Gln Gln Tyr Lys Lys Asp Gln Asn Leu Leu Ser Pro 
                85                  90                  95      


Val Asn Cys Trp Tyr Leu Leu Leu Asn Gln Val Arg Arg Glu Ser Lys 
            100                 105                 110         


Asp His Ala Thr Leu Ser Asp Ile Tyr Leu Asn Asn Val Ile Met Arg 
        115                 120                 125             


Phe Met Gln Ile Ser Glu Asp Ser Thr Arg Met Phe Lys Lys Ser Lys 
    130                 135                 140                 


Glu Ile Ala Phe Gln Leu His Glu Asp Leu Met Lys Val Leu Asn Glu 
145                 150                 155                 160 


Leu Tyr Thr Val Met Lys Thr Tyr His Met Tyr His Ala Glu Ser Ile 
                165                 170                 175     


Ser Ala Glu Ser Lys Leu Lys Glu Ala Glu Lys Gln Glu Glu Lys Gln 
            180                 185                 190         


Ile Gly Arg Ser Gly Asp Pro Val Phe His Ile Arg Leu Glu Glu Arg 
        195                 200                 205             


His Gln Arg Arg Ser Ser Val Lys Lys Ile Glu Lys Met Lys Glu Lys 
    210                 215                 220                 


Arg Gln Ala Lys Tyr Ser Glu Asn Lys Leu Lys Ser Ile Lys Ala Arg 
225                 230                 235                 240 


Asn Glu Tyr Leu Leu Thr Leu Glu Ala Thr Asn Ala Ser Val Phe Lys 
                245                 250                 255     


Tyr Tyr Ile His Asp Leu Ser Asp Leu Ile Asp Cys Cys Asp Leu Gly 
            260                 265                 270         


Tyr His Ala Ser Leu Asn Arg Ala Leu Arg Thr Tyr Leu Ser Ala Glu 
        275                 280                 285             


Tyr Asn Leu Glu Thr Ser Arg His Glu Gly Leu Asp Ile Ile Glu Asn 
    290                 295                 300                 


Ala Val Asp Asn Leu Glu Pro Arg Ser Asp Lys Gln Arg Phe Met Glu 
305                 310                 315                 320 


Met Tyr Pro Ala Ala Phe Cys Pro Pro Met Lys Phe Glu Phe Gln Ser 
                325                 330                 335     


His Met Gly Asp Glu Val Cys Gln Val Ser Ala Gln Gln Pro Val Gln 
            340                 345                 350         


Ala Glu Leu Met Leu Arg Tyr Gln Gln Leu Gln Ser Arg Leu Ala Thr 
        355                 360                 365             


Leu Lys Ile Glu Asn Glu Glu Val Lys Lys Thr Thr Glu Ala Thr Leu 
    370                 375                 380                 


Gln Thr Ile Gln Asp Met Val Thr Ile Glu Asp Tyr Asp Val Ser Glu 
385                 390                 395                 400 


Cys Phe Gln His Ser Arg Ser Thr Glu Ser Val Lys Ser Thr Val Ser 
                405                 410                 415     


Glu Thr Tyr Leu Ser Lys Pro Ser Ile Ala Lys Arg Arg Ala Asn Gln 
            420                 425                 430         


Gln Glu Thr Glu Gln Phe Tyr Phe Met Lys Leu Arg Glu Tyr Leu Glu 
        435                 440                 445             


Gly Ser Asn Leu Ile Thr Lys Leu Gln Ala Lys His Asp Leu Leu Gln 
    450                 455                 460                 


Arg Thr Leu Gly Glu Gly His Arg Ala Glu Tyr Met Thr Thr Arg Pro 
465                 470                 475                 480 


Pro Asn Val Pro Pro Lys Pro Gln Lys His Arg Lys Ser Arg Pro Arg 
                485                 490                 495     


Ser Gln Tyr Asn Thr Lys Leu Phe Asn Gly Asp Leu Glu Thr Phe Val 
            500                 505                 510         


Lys Asp Ser Gly Gln Val Ile Pro Leu Ile Val Glu Ser Cys Ile Arg 
        515                 520                 525             


Phe Ile Asn Leu Tyr Gly Leu Gln His Gln Gly Ile Phe Arg Val Ser 
    530                 535                 540                 


Gly Ser Gln Val Glu Val Asn Asp Ile Lys Asn Ser Phe Glu Arg Gly 
545                 550                 555                 560 


Glu Asn Pro Leu Ala Asp Asp Gln Ser Asn His Asp Ile Asn Ser Val 
                565                 570                 575     


Ala Gly Val Leu Lys Leu Tyr Phe Arg Gly Leu Glu Asn Pro Leu Phe 
            580                 585                 590         


Pro Lys Glu Arg Phe Asn Asp Leu Ile Ser Cys Ile Arg Ile Asp Asn 
        595                 600                 605             


Leu Tyr Glu Arg Ala Leu His Ile Arg Lys Leu Leu Leu Thr Leu Pro 
    610                 615                 620                 


Arg Ser Val Leu Ile Val Met Arg Tyr Leu Phe Ala Phe Leu Asn His 
625                 630                 635                 640 


Leu Ser Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu Ala 
                645                 650                 655     


Ile Cys Phe Gly Pro Thr Leu Met Pro Val Pro Glu Ile Gln Asp Gln 
            660                 665                 670         


Val Ser Cys Gln Ala His Val Asn Glu Ile Ile Lys Thr Ile Ile Ile 
        675                 680                 685             


His His Glu Thr Ile Phe Pro Asp Ala Lys Glu Leu Asp Gly Pro Val 
    690                 695                 700                 


Tyr Glu Lys Cys Met Ala Gly Asp Asp Tyr Cys Asp Ser Pro Tyr Ser 
705                 710                 715                 720 


Glu His Gly Thr Leu Glu Glu Val Asp Gln Asp Ala Gly Thr Glu Pro 
                725                 730                 735     


His Thr Ser Glu Asp Glu Cys Glu Pro Ile Glu Ala Ile Ala Lys Phe 
            740                 745                 750         


Asp Tyr Val Gly Arg Ser Ala Arg Glu Leu Ser Phe Lys Lys Gly Ala 
        755                 760                 765             


Ser Leu Leu Leu Tyr His Arg Ala Ser Glu Asp Trp Trp Glu Gly Arg 
    770                 775                 780                 


His Asn Gly Ile Asp Gly Leu Val Pro His Gln Tyr Ile Val Val Gln 
785                 790                 795                 800 


Asp Met Asp Asp Thr Phe Ser Asp Thr Leu Ser Gln Lys Ala Asp Ser 
                805                 810                 815     


Glu Ala Ser Ser Gly Pro Val Thr Glu Asp Lys Ser Ser Ser Lys Asp 
            820                 825                 830         


Met Asn Ser Pro Thr Asp Arg His Pro Asp Gly Tyr Leu Ala Arg Gln 
        835                 840                 845             


Arg Lys Arg Gly Glu Pro Pro Pro Pro Val Arg Arg Pro Gly Arg Thr 
    850                 855                 860                 


Ser Asp Gly His Cys Pro Leu His Pro Pro His Ala Leu Ser Asn Ser 
865                 870                 875                 880 


Ser Val Asp Leu Gly Ser Pro Ser Leu Ala Ser His Pro Arg Gly Leu 
                885                 890                 895     


Leu Gln Asn Arg Gly Leu Asn Asn Asp Ser Pro Glu Arg Arg Arg Arg 
            900                 905                 910         


Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His Asp Ser Leu Lys 
        915                 920                 925             


Lys Ile Asp Ser Pro Pro Ile Arg Arg Ser Thr Ser Ser Gly Gln Tyr 
    930                 935                 940                 


Thr Gly Phe Asn Asp His Lys Pro Leu Asp Pro Glu Thr Ile Ala Gln 
945                 950                 955                 960 


Asp Ile Glu Glu Thr Met Asn Thr Ala Leu Asn Glu Leu Arg Glu Leu 
                965                 970                 975     


Glu Arg Gln Ser Thr Ala Lys His Ala Pro Asp Val Val Leu Asp Thr 
            980                 985                 990         


Leu Glu Gln Val Lys Asn Ser Pro  Thr Pro Ala Thr Ser  Thr Glu Ser 
        995                 1000                 1005             


Leu Ser  Pro Leu His Asn Val  Ala Leu Arg Ser Ser  Glu Pro Gln 
    1010                 1015                 1020             


Ile Arg  Arg Ser Thr Ser Ser  Ser Ser Asp Thr Met  Ser Thr Phe 
    1025                 1030                 1035             


Lys Pro  Met Val Ala Pro Arg  Met Gly Val Gln Leu  Lys Pro Pro 
    1040                 1045                 1050             


Ala Leu  Arg Pro Lys Pro Ala  Val Leu Pro Lys Thr  Asn Pro Thr 
    1055                 1060                 1065             


Ile Gly  Pro Ala Pro Pro Pro  Gln Gly Pro Thr Asp  Lys Ser Cys 
    1070                 1075                 1080             


Thr Met  
    1085 


<210>  68
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  69
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  70
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu 
1               5                   10                  15      


Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg 
            20                  25                  30          


Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro 
        35                  40                  45              


Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg 
    50                  55                  60                  


Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu 
65                  70                  75                  80  


Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg 
                85                  90                  95      


His Lys Val Thr Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His 
            100                 105                 110         


Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile 
        115                 120                 125             


Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val 
    130                 135                 140                 


Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly 
145                 150                 155                 160 


Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu 
                165                 170                 175     


Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr 
            180                 185                 190         


Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn 
        195                 200                 205             


Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val 
    210                 215                 220             


<210>  71
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  72
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Val Val Met Ala Arg Leu Ser Arg Pro Glu Arg Pro Asp Leu Val 
1               5                   10                  15      


Phe Glu Glu Glu Asp Leu Pro Tyr Glu Glu Glu Ile Met Arg Asn Gln 
            20                  25                  30          


Phe Ser Val Lys Cys Trp Leu Arg Tyr Ile Glu Phe Lys Gln Gly Ala 
        35                  40                  45              


Pro Lys Pro Arg Leu Asn Gln Leu Tyr Glu Arg Ala Leu Lys Leu Leu 
    50                  55                  60                  


Pro Cys Ser Tyr Lys Leu Trp Tyr Arg Tyr Leu Lys Ala Arg Arg Ala 
65                  70                  75                  80  


Gln Val Lys His Arg Cys Val Thr Asp Pro Ala Tyr Glu Asp Val Asn 
                85                  90                  95      


Asn Cys His Glu Arg Ala Phe Val Phe Met His Lys Met Pro Arg Leu 
            100                 105                 110         


Trp Leu Asp Tyr Cys Gln Phe Leu Met Asp Gln Gly Arg Val Thr His 
        115                 120                 125             


Thr Arg Arg Thr Phe Asp Arg Ala Leu Arg Ala Leu Pro Ile Thr Gln 
    130                 135                 140                 


His Ser Arg Ile Trp Pro Leu Tyr Leu Arg Phe Leu Arg Ser His Pro 
145                 150                 155                 160 


Leu Pro Glu Thr Ala Val Arg Gly Tyr Arg Arg Phe Leu Lys Leu Ser 
                165                 170                 175     


Pro Glu Ser Ala Glu Glu Tyr Ile Glu Tyr Leu Lys Ser Ser Asp Arg 
            180                 185                 190         


Leu Asp Glu Ala Ala Gln Arg Leu Ala Thr Val Val Asn Asp Glu Arg 
        195                 200                 205             


Phe Val Ser Lys Ala Gly Lys Ser Asn Tyr Gln Leu Trp His Glu Leu 
    210                 215                 220                 


Cys Asp Leu Ile Ser Gln Asn Pro Asp Lys Val Gln Ser Leu Asn Val 
225                 230                 235                 240 


Asp Ala Ile Ile Arg Gly Gly Leu Thr Arg Phe Thr Asp Gln Leu Gly 
                245                 250                 255     


Lys Leu Trp Cys Ser Leu Ala Asp Tyr Tyr Ile Arg Ser Gly His Phe 
            260                 265                 270         


Glu Lys Ala Arg Asp Val Tyr Glu Glu Ala Ile Arg Thr Val Met Thr 
        275                 280                 285             


Val Arg Asp Phe Thr Gln Val Phe Asp Ser Tyr Ala Gln Phe Glu Glu 
    290                 295                 300                 


Ser Met Ile Ala Ala Lys Met Glu Thr Ala Ser Glu Leu Gly Arg Glu 
305                 310                 315                 320 


Glu Glu Asp Asp Val Asp Leu Glu Leu Arg Leu Ala Arg Phe Glu Gln 
                325                 330                 335     


Leu Ile Ser Arg Arg Pro Leu Leu Leu Asn Ser Val Leu Leu Arg Gln 
            340                 345                 350         


Asn Pro His His Val His Glu Trp His Lys Arg Val Ala Leu His Gln 
        355                 360                 365             


Gly Arg Pro Arg Glu Ile Ile Asn Thr Tyr Thr Glu Ala Val Gln Thr 
    370                 375                 380                 


Val Asp Pro Phe Lys Ala Thr Gly Lys Pro His Thr Leu Trp Val Ala 
385                 390                 395                 400 


Phe Ala Lys Phe Tyr Glu Asp Asn Gly Gln Leu Asp Asp Ala Arg Val 
                405                 410                 415     


Ile Leu Glu Lys Ala Thr Lys Val Asn Phe Lys Gln Val Asp Asp Leu 
            420                 425                 430         


Ala Ser Val Trp Cys Gln Cys Gly Glu Leu Glu Leu Arg His Glu Asn 
        435                 440                 445             


Tyr Asp Glu Ala Leu Arg Leu Leu Arg Lys Ala Thr Ala Leu Pro Ala 
    450                 455                 460                 


Arg Arg Ala Glu Tyr Phe Asp Gly Ser Glu Pro Val Gln Asn Arg Val 
465                 470                 475                 480 


Tyr Lys Ser Leu Lys Val Trp Ser Met Leu Ala Asp Leu Glu Glu Ser 
                485                 490                 495     


Leu Gly Thr Phe Gln Ser Thr Lys Ala Val Tyr Asp Arg Ile Leu Asp 
            500                 505                 510         


Leu Arg Ile Ala Thr Pro Gln Ile Val Ile Asn Tyr Ala Met Phe Leu 
        515                 520                 525             


Glu Glu His Lys Tyr Phe Glu Glu Ser Phe Lys Ala Tyr Glu Arg Gly 
    530                 535                 540                 


Ile Ser Leu Phe Lys Trp Pro Asn Val Ser Asp Ile Trp Ser Thr Tyr 
545                 550                 555                 560 


Leu Thr Lys Phe Ile Ala Arg Tyr Gly Gly Arg Lys Leu Glu Arg Ala 
                565                 570                 575     


Arg Asp Leu Phe Glu Gln Ala Leu Asp Gly Cys Pro Pro Lys Tyr Ala 
            580                 585                 590         


Lys Thr Leu Tyr Leu Leu Tyr Ala Gln Leu Glu Glu Glu Trp Gly Leu 
        595                 600                 605             


Ala Arg His Ala Met Ala Val Tyr Glu Arg Ala Thr Arg Ala Val Glu 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Asp Met Phe Asn Ile Tyr Ile Lys Arg Ala Ala 
625                 630                 635                 640 


Glu Ile Tyr Gly Val Thr His Thr Arg Gly Ile Tyr Gln Lys Ala Ile 
                645                 650                 655     


Glu Val Leu Ser Asp Glu His Ala Arg Glu Met Cys Leu Arg Phe Ala 
            660                 665                 670         


Asp Met Glu Cys Lys Leu Gly Glu Ile Asp Arg Ala Arg Ala Ile Tyr 
        675                 680                 685             


Ser Phe Cys Ser Gln Ile Cys Asp Pro Arg Thr Thr Gly Ala Phe Trp 
    690                 695                 700                 


Gln Thr Trp Lys Asp Phe Glu Val Arg His Gly Asn Glu Asp Thr Ile 
705                 710                 715                 720 


Lys Glu Met Leu Arg Ile Arg Arg Ser Val Gln Ala Thr Tyr Asn Thr 
                725                 730                 735     


Gln Val Asn Phe Met Ala Ser Gln Met Leu Lys Val Ser Gly Ser Ala 
            740                 745                 750         


Thr Gly Thr Val Ser Asp Leu Ala Pro Gly Gln Ser Gly Met Asp Asp 
        755                 760                 765             


Met Lys Leu Leu Glu Gln Arg Ala Glu Gln Leu Ala Ala Glu Ala Glu 
    770                 775                 780                 


Arg Asp Gln Pro Leu Arg Ala Gln Ser Lys Ile Leu Phe Val Arg Ser 
785                 790                 795                 800 


Asp Ala Ser Arg Glu Glu Leu Ala Glu Leu Ala Gln Gln Val Asn Pro 
                805                 810                 815     


Glu Glu Ile Gln Leu Gly Glu Asp Glu Asp Glu Asp Glu Met Asp Leu 
            820                 825                 830         


Glu Pro Asn Glu Val Arg Leu Glu Gln Gln Ser Val Pro Ala Ala Val 
        835                 840                 845             


Phe Gly Ser Leu Lys Glu Asp 
    850                 855 


<210>  73
<211>  2785
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Lys Thr Lys Pro Val Ser His Lys Thr Glu Asn Thr Tyr Arg Phe 
1               5                   10                  15      


Leu Thr Phe Ala Glu Arg Leu Gly Asn Val Asn Ile Asp Ile Ile His 
            20                  25                  30          


Arg Ile Asp Arg Thr Ala Ser Tyr Glu Glu Glu Val Glu Thr Tyr Phe 
        35                  40                  45              


Phe Glu Gly Leu Leu Lys Trp Arg Glu Leu Asn Leu Thr Glu His Phe 
    50                  55                  60                  


Gly Lys Phe Tyr Lys Glu Val Ile Asp Lys Cys Gln Ser Phe Asn Gln 
65                  70                  75                  80  


Leu Val Tyr His Gln Asn Glu Ile Val Gln Ser Leu Lys Thr His Leu 
                85                  90                  95      


Gln Val Lys Asn Ser Phe Ala Tyr Gln Pro Leu Leu Asp Leu Val Val 
            100                 105                 110         


Gln Leu Ala Arg Asp Leu Gln Met Asp Phe Tyr Pro His Phe Pro Glu 
        115                 120                 125             


Phe Phe Leu Thr Ile Thr Ser Ile Leu Glu Thr Gln Asp Thr Glu Leu 
    130                 135                 140                 


Leu Glu Trp Ala Phe Thr Ser Leu Ser Tyr Leu Tyr Lys Tyr Leu Trp 
145                 150                 155                 160 


Arg Leu Met Val Lys Asp Met Ser Ser Ile Tyr Ser Met Tyr Ser Thr 
                165                 170                 175     


Leu Leu Ala His Lys Lys Leu His Ile Arg Asn Phe Ala Ala Glu Ser 
            180                 185                 190         


Phe Thr Phe Leu Met Arg Lys Val Ser Asp Lys Asn Ala Leu Phe Asn 
        195                 200                 205             


Leu Met Phe Leu Asp Leu Asp Lys His Pro Glu Lys Val Glu Gly Val 
    210                 215                 220                 


Gly Gln Leu Leu Phe Glu Met Cys Lys Gly Val Arg Asn Met Phe His 
225                 230                 235                 240 


Ser Cys Thr Gly Gln Ala Val Lys Leu Ile Leu Arg Lys Leu Gly Pro 
                245                 250                 255     


Val Thr Glu Thr Glu Thr Gln Leu Pro Trp Met Leu Ile Gly Glu Thr 
            260                 265                 270         


Leu Lys Asn Met Val Lys Ser Thr Val Ser Tyr Ile Ser Lys Glu His 
        275                 280                 285             


Phe Gly Thr Phe Phe Glu Cys Leu Gln Glu Ser Leu Leu Asp Leu His 
    290                 295                 300                 


Thr Lys Val Thr Lys Thr Asn Cys Cys Glu Ser Ser Glu Gln Ile Lys 
305                 310                 315                 320 


Arg Leu Leu Glu Thr Tyr Leu Ile Leu Val Lys His Gly Ser Gly Thr 
                325                 330                 335     


Lys Ile Pro Thr Pro Ala Asp Val Cys Lys Val Leu Ser Gln Thr Leu 
            340                 345                 350         


Gln Val Ala Ser Leu Ser Thr Ser Cys Trp Glu Thr Leu Leu Asp Val 
        355                 360                 365             


Ile Ser Ala Leu Ile Leu Gly Glu Asn Val Ser Leu Pro Glu Thr Leu 
    370                 375                 380                 


Ile Lys Glu Thr Ile Glu Lys Ile Phe Glu Ser Arg Phe Glu Lys Arg 
385                 390                 395                 400 


Leu Ile Phe Ser Phe Ser Glu Val Met Phe Ala Met Lys Gln Phe Glu 
                405                 410                 415     


Gln Leu Phe Leu Pro Ser Phe Leu Ser Tyr Ile Val Asn Cys Phe Leu 
            420                 425                 430         


Ile Asp Asp Ala Val Val Lys Asp Glu Ala Leu Ala Ile Leu Ala Lys 
        435                 440                 445             


Leu Ile Leu Asn Lys Ala Ala Pro Pro Thr Ala Gly Ser Met Ala Ile 
    450                 455                 460                 


Glu Lys Tyr Pro Leu Val Phe Ser Pro Gln Met Val Gly Phe Tyr Ile 
465                 470                 475                 480 


Lys Gln Lys Lys Thr Arg Ser Lys Gly Arg Asn Glu Gln Phe Pro Val 
                485                 490                 495     


Leu Asp His Leu Leu Ser Ile Ile Lys Leu Pro Pro Asn Lys Asp Thr 
            500                 505                 510         


Thr Tyr Leu Ser Gln Ser Trp Ala Ala Leu Val Val Leu Pro His Ile 
        515                 520                 525             


Arg Pro Leu Glu Lys Glu Lys Val Ile Pro Leu Val Thr Gly Phe Ile 
    530                 535                 540                 


Glu Ala Leu Phe Met Thr Val Asp Lys Gly Ser Phe Gly Lys Gly Asn 
545                 550                 555                 560 


Leu Phe Val Leu Cys Gln Ala Val Asn Thr Leu Leu Ser Leu Glu Glu 
                565                 570                 575     


Ser Ser Glu Leu Leu His Leu Val Pro Val Glu Arg Val Lys Asn Leu 
            580                 585                 590         


Val Leu Thr Phe Pro Leu Glu Pro Ser Val Leu Leu Leu Thr Asp Leu 
        595                 600                 605             


Tyr Tyr Gln Arg Leu Ala Leu Cys Gly Cys Lys Gly Pro Leu Ser Gln 
    610                 615                 620                 


Glu Ala Leu Met Glu Leu Phe Pro Lys Leu Gln Ala Asn Ile Ser Thr 
625                 630                 635                 640 


Gly Val Ser Lys Ile Arg Leu Leu Thr Ile Arg Ile Leu Asn His Phe 
                645                 650                 655     


Asp Val Gln Leu Pro Glu Ser Met Glu Asp Asp Gly Leu Ser Glu Arg 
            660                 665                 670         


Gln Ser Val Phe Ala Ile Leu Arg Gln Ala Glu Leu Val Pro Ala Thr 
        675                 680                 685             


Val Asn Asp Tyr Arg Glu Lys Leu Leu His Leu Arg Lys Leu Arg His 
    690                 695                 700                 


Asp Val Val Gln Thr Ala Val Pro Asp Gly Pro Leu Gln Glu Val Pro 
705                 710                 715                 720 


Leu Arg Tyr Leu Leu Gly Met Leu Tyr Ile Asn Phe Ser Ala Leu Trp 
                725                 730                 735     


Asp Pro Val Ile Glu Leu Ile Ser Ser His Ala His Glu Met Glu Asn 
            740                 745                 750         


Lys Gln Phe Trp Lys Val Tyr Tyr Glu His Leu Glu Lys Ala Ala Thr 
        755                 760                 765             


His Ala Glu Lys Glu Leu Gln Asn Asp Met Thr Asp Glu Lys Ser Val 
    770                 775                 780                 


Gly Asp Glu Ser Trp Glu Gln Thr Gln Glu Gly Asp Val Gly Ala Leu 
785                 790                 795                 800 


Tyr His Glu Gln Leu Ala Leu Lys Thr Asp Cys Gln Glu Arg Leu Asp 
                805                 810                 815     


His Thr Asn Phe Arg Phe Leu Leu Trp Arg Ala Leu Thr Lys Phe Pro 
            820                 825                 830         


Glu Arg Val Glu Pro Arg Ser Arg Glu Leu Ser Pro Leu Phe Leu Arg 
        835                 840                 845             


Phe Ile Asn Asn Glu Tyr Tyr Pro Ala Asp Leu Gln Val Ala Pro Thr 
    850                 855                 860                 


Gln Asp Leu Arg Arg Lys Gly Lys Gly Met Val Ala Glu Glu Ile Glu 
865                 870                 875                 880 


Glu Glu Pro Ala Ala Gly Asp Asp Glu Glu Leu Glu Glu Glu Ala Val 
                885                 890                 895     


Pro Gln Asp Glu Ser Ser Gln Lys Lys Lys Thr Arg Arg Ala Ala Ala 
            900                 905                 910         


Lys Gln Leu Ile Ala His Leu Gln Val Phe Ser Lys Phe Ser Asn Pro 
        915                 920                 925             


Arg Ala Leu Tyr Leu Glu Ser Lys Leu Tyr Glu Leu Tyr Leu Gln Leu 
    930                 935                 940                 


Leu Leu His Gln Asp Gln Met Val Gln Lys Ile Thr Leu Asp Cys Ile 
945                 950                 955                 960 


Met Thr Tyr Lys His Pro His Val Leu Pro Tyr Arg Glu Asn Leu Gln 
                965                 970                 975     


Arg Leu Leu Glu Asp Arg Ser Phe Lys Glu Glu Ile Val His Phe Ser 
            980                 985                 990         


Ile Ser Glu Asp Asn Ala Val Val  Lys Thr Ala His Arg  Ala Asp Leu 
        995                 1000                 1005             


Phe Pro  Ile Leu Met Arg Ile  Leu Tyr Gly Arg Met  Lys Asn Lys 
    1010                 1015                 1020             


Thr Gly  Ser Lys Thr Gln Gly  Lys Ser Ala Ser Gly  Thr Arg Met 
    1025                 1030                 1035             


Ala Ile  Val Leu Arg Phe Leu  Ala Gly Thr Gln Pro  Glu Glu Ile 
    1040                 1045                 1050             


Gln Ile  Phe Leu Asp Leu Leu  Phe Glu Pro Val Arg  His Phe Lys 
    1055                 1060                 1065             


Asn Gly  Glu Cys His Ser Ala  Val Ile Gln Ala Val  Glu Asp Leu 
    1070                 1075                 1080             


Asp Leu  Ser Lys Val Leu Pro  Leu Gly Arg Gln His  Gly Ile Leu 
    1085                 1090                 1095             


Asn Ser  Leu Glu Ile Val Leu  Lys Asn Ile Ser His  Leu Ile Ser 
    1100                 1105                 1110             


Ala Tyr  Leu Pro Lys Ile Leu  Gln Ile Leu Leu Cys  Met Thr Ala 
    1115                 1120                 1125             


Thr Val  Ser His Ile Leu Asp  Gln Arg Glu Lys Ile  Gln Leu Arg 
    1130                 1135                 1140             


Phe Ile  Asn Pro Leu Lys Asn  Leu Arg Arg Leu Gly  Ile Lys Met 
    1145                 1150                 1155             


Val Thr  Asp Ile Phe Leu Asp  Trp Glu Ser Tyr Gln  Phe Arg Thr 
    1160                 1165                 1170             


Glu Glu  Ile Asp Ala Val Phe  His Gly Ala Val Trp  Pro Gln Ile 
    1175                 1180                 1185             


Ser Arg  Leu Gly Ser Glu Ser  Gln Tyr Ser Pro Thr  Pro Leu Leu 
    1190                 1195                 1200             


Lys Leu  Ile Ser Ile Trp Ser  Arg Asn Ala Arg Tyr  Phe Pro Leu 
    1205                 1210                 1215             


Leu Ala  Lys Gln Lys Pro Gly  His Pro Glu Cys Asp  Ile Leu Thr 
    1220                 1225                 1230             


Asn Val  Phe Ala Ile Leu Ser  Ala Lys Asn Leu Ser  Asp Ala Thr 
    1235                 1240                 1245             


Ala Ser  Ile Val Met Asp Ile  Val Asp Asp Leu Leu  Asn Leu Pro 
    1250                 1255                 1260             


Asp Phe  Glu Pro Thr Glu Thr  Val Leu Asn Leu Leu  Val Thr Gly 
    1265                 1270                 1275             


Cys Val  Tyr Pro Gly Ile Ala  Glu Asn Ile Gly Glu  Ser Ile Thr 
    1280                 1285                 1290             


Ile Gly  Gly Arg Leu Ile Leu  Pro His Val Pro Ala  Ile Leu Gln 
    1295                 1300                 1305             


Tyr Leu  Ser Lys Thr Thr Ile  Ser Ala Glu Lys Val  Lys Lys Lys 
    1310                 1315                 1320             


Lys Asn  Arg Ala Gln Val Ser  Lys Glu Leu Gly Ile  Leu Ser Lys 
    1325                 1330                 1335             


Ile Ser  Lys Phe Met Lys Asp  Lys Glu Gln Ser Ser  Val Leu Ile 
    1340                 1345                 1350             


Thr Leu  Leu Leu Pro Phe Leu  His Arg Gly Asn Ile  Ala Glu Asp 
    1355                 1360                 1365             


Thr Glu  Val Asp Ile Leu Val  Thr Val Gln Asn Leu  Leu Lys His 
    1370                 1375                 1380             


Cys Val  Asp Pro Thr Ser Phe  Leu Lys Pro Ile Ala  Lys Leu Phe 
    1385                 1390                 1395             


Ser Val  Ile Lys Asn Lys Leu  Ser Arg Lys Leu Leu  Cys Thr Val 
    1400                 1405                 1410             


Phe Glu  Thr Leu Ser Asp Phe  Glu Ser Gly Leu Lys  Tyr Ile Thr 
    1415                 1420                 1425             


Asp Val  Val Lys Leu Asn Ala  Phe Asp Gln Arg His  Leu Asp Asp 
    1430                 1435                 1440             


Ile Asn  Phe Asp Val Arg Phe  Glu Thr Phe Gln Thr  Ile Thr Ser 
    1445                 1450                 1455             


Tyr Ile  Lys Glu Met Gln Ile  Val Asp Val Asn Tyr  Leu Ile Pro 
    1460                 1465                 1470             


Val Met  His Asn Cys Phe Tyr  Asn Leu Glu Leu Gly  Asp Met Ser 
    1475                 1480                 1485             


Leu Ser  Asp Asn Ala Ser Met  Cys Leu Met Ser Ile  Ile Lys Lys 
    1490                 1495                 1500             


Leu Ala  Ala Leu Asn Val Thr  Glu Lys Asp Tyr Arg  Glu Ile Ile 
    1505                 1510                 1515             


His Arg  Ser Leu Leu Glu Lys  Leu Arg Lys Gly Leu  Lys Ser Gln 
    1520                 1525                 1530             


Thr Glu  Ser Ile Gln Gln Asp  Tyr Thr Thr Ile Leu  Ser Cys Leu 
    1535                 1540                 1545             


Ile Gln  Thr Phe Pro Asn Gln  Leu Glu Phe Lys Asp  Leu Val Gln 
    1550                 1555                 1560             


Leu Thr  His Tyr His Asp Pro  Glu Met Asp Phe Phe  Glu Asn Met 
    1565                 1570                 1575             


Lys His  Ile Gln Ile His Arg  Arg Ala Arg Ala Leu  Lys Lys Leu 
    1580                 1585                 1590             


Ala Lys  Gln Leu Met Glu Gly  Lys Val Val Leu Ser  Ser Lys Ser 
    1595                 1600                 1605             


Leu Gln  Asn Tyr Ile Met Pro  Tyr Ala Met Thr Pro  Ile Phe Asp 
    1610                 1615                 1620             


Glu Lys  Met Leu Lys His Glu  Asn Ile Thr Thr Ala  Ala Thr Glu 
    1625                 1630                 1635             


Ile Ile  Gly Ala Ile Cys Lys  His Leu Ser Trp Ser  Ala Tyr Met 
    1640                 1645                 1650             


Tyr Tyr  Leu Lys His Phe Ile  His Val Leu Gln Thr  Gly Gln Ile 
    1655                 1660                 1665             


Asn Gln  Lys Leu Gly Val Ser  Leu Leu Val Ile Val  Leu Glu Ala 
    1670                 1675                 1680             


Phe His  Phe Asp His Lys Thr  Leu Glu Glu Gln Met  Gly Lys Ile 
    1685                 1690                 1695             


Glu Asn  Glu Glu Asn Ala Ile  Glu Ala Ile Glu Leu  Pro Glu Pro 
    1700                 1705                 1710             


Glu Ala  Met Glu Leu Glu Arg  Val Asp Glu Glu Glu  Lys Glu Tyr 
    1715                 1720                 1725             


Thr Cys  Lys Ser Leu Ser Asp  Asn Gly Gln Pro Gly  Thr Pro Asp 
    1730                 1735                 1740             


Pro Ala  Asp Ser Gly Gly Thr  Ser Ala Lys Glu Ser  Glu Cys Ile 
    1745                 1750                 1755             


Thr Lys  Pro Val Ser Phe Leu  Pro Gln Asn Lys Glu  Glu Ile Glu 
    1760                 1765                 1770             


Arg Thr  Ile Lys Asn Ile Gln  Gly Thr Ile Thr Gly  Asp Ile Leu 
    1775                 1780                 1785             


Pro Arg  Leu His Lys Cys Leu  Ala Ser Thr Thr Lys  Arg Glu Glu 
    1790                 1795                 1800             


Glu His  Lys Leu Val Lys Ser  Lys Val Val Asn Asp  Glu Glu Val 
    1805                 1810                 1815             


Val Arg  Val Pro Leu Ala Phe  Ala Met Val Lys Leu  Met Gln Ser 
    1820                 1825                 1830             


Leu Pro  Gln Glu Val Met Glu  Ala Asn Leu Pro Ser  Ile Leu Leu 
    1835                 1840                 1845             


Lys Val  Cys Ala Leu Leu Lys  Asn Arg Ala Gln Glu  Ile Arg Asp 
    1850                 1855                 1860             


Ile Ala  Arg Ser Thr Leu Ala  Lys Ile Ile Glu Asp  Leu Gly Val 
    1865                 1870                 1875             


His Phe  Leu Leu Tyr Val Leu  Lys Glu Leu Gln Thr  Thr Leu Val 
    1880                 1885                 1890             


Arg Gly  Tyr Gln Val His Val  Leu Thr Phe Thr Val  His Met Leu 
    1895                 1900                 1905             


Leu Gln  Gly Leu Thr Asn Lys  Leu Gln Val Gly Asp  Leu Asp Ser 
    1910                 1915                 1920             


Cys Leu  Asp Ile Met Ile Glu  Ile Phe Asn His Glu  Leu Phe Gly 
    1925                 1930                 1935             


Ala Val  Ala Glu Glu Lys Glu  Val Lys Gln Ile Leu  Ser Lys Val 
    1940                 1945                 1950             


Met Glu  Ala Arg Arg Ser Lys  Ser Tyr Asp Ser Tyr  Glu Ile Leu 
    1955                 1960                 1965             


Gly Lys  Phe Val Gly Lys Asp  Gln Val Thr Lys Leu  Ile Leu Pro 
    1970                 1975                 1980             


Leu Lys  Glu Ile Leu Gln Asn  Thr Thr Ser Leu Lys  Leu Ala Arg 
    1985                 1990                 1995             


Lys Val  His Glu Thr Leu Arg  Arg Ile Thr Val Gly  Leu Ile Val 
    2000                 2005                 2010             


Asn Gln  Glu Met Thr Ala Glu  Ser Ile Leu Leu Leu  Ser Tyr Gly 
    2015                 2020                 2025             


Leu Ile  Ser Glu Asn Leu Pro  Leu Leu Thr Glu Lys  Glu Lys Asn 
    2030                 2035                 2040             


Pro Val  Ala Pro Ala Pro Asp  Pro Arg Leu Pro Pro  Gln Ser Cys 
    2045                 2050                 2055             


Leu Leu  Leu Pro Pro Thr Pro  Val Arg Gly Gly Gln  Lys Ala Val 
    2060                 2065                 2070             


Val Ser  Arg Lys Thr Asn Met  His Ile Phe Ile Glu  Ser Gly Leu 
    2075                 2080                 2085             


Arg Leu  Leu His Leu Ser Leu  Lys Thr Ser Lys Ile  Lys Ser Ser 
    2090                 2095                 2100             


Gly Glu  Cys Val Leu Glu Met  Leu Asp Pro Phe Val  Ser Leu Leu 
    2105                 2110                 2115             


Ile Asp  Cys Leu Gly Ser Met  Asp Val Lys Val Ile  Thr Gly Ala 
    2120                 2125                 2130             


Leu Gln  Cys Leu Ile Trp Val  Leu Arg Phe Pro Leu  Pro Ser Ile 
    2135                 2140                 2145             


Glu Thr  Lys Ala Glu Gln Leu  Thr Lys His Leu Phe  Leu Leu Leu 
    2150                 2155                 2160             


Lys Asp  Tyr Ala Lys Leu Gly  Ala Ala Arg Gly Gln  Asn Phe His 
    2165                 2170                 2175             


Leu Val  Val Asn Cys Phe Lys  Cys Val Thr Ile Leu  Val Lys Lys 
    2180                 2185                 2190             


Val Lys  Ser Tyr Gln Ile Thr  Glu Lys Gln Leu Gln  Val Leu Leu 
    2195                 2200                 2205             


Ala Tyr  Ala Glu Glu Asp Ile  Tyr Asp Thr Ser Arg  Gln Ala Thr 
    2210                 2215                 2220             


Ala Phe  Gly Leu Leu Lys Ala  Ile Leu Ser Arg Lys  Leu Leu Val 
    2225                 2230                 2235             


Pro Glu  Ile Asp Glu Val Met  Arg Lys Val Ser Lys  Leu Ala Val 
    2240                 2245                 2250             


Ser Ala  Gln Ser Glu Pro Ala  Arg Val Gln Cys Arg  Gln Val Phe 
    2255                 2260                 2265             


Leu Lys  Tyr Ile Leu Asp Tyr  Pro Leu Gly Asp Lys  Leu Arg Pro 
    2270                 2275                 2280             


Asn Leu  Glu Phe Met Leu Ala  Gln Leu Asn Tyr Glu  His Glu Thr 
    2285                 2290                 2295             


Gly Arg  Glu Ser Thr Leu Glu  Met Ile Ala Tyr Leu  Phe Asp Thr 
    2300                 2305                 2310             


Phe Pro  Gln Gly Leu Leu His  Glu Asn Cys Gly Met  Phe Phe Ile 
    2315                 2320                 2325             


Pro Leu  Cys Leu Met Thr Ile  Asn Asp Asp Ser Ala  Thr Cys Lys 
    2330                 2335                 2340             


Lys Met  Ala Ser Met Thr Ile  Lys Ser Leu Leu Gly  Lys Ile Ser 
    2345                 2350                 2355             


Leu Glu  Lys Lys Asp Trp Leu  Phe Asp Met Val Thr  Thr Trp Phe 
    2360                 2365                 2370             


Gly Ala  Lys Lys Arg Leu Asn  Arg Gln Leu Ala Ala  Leu Ile Cys 
    2375                 2380                 2385             


Gly Leu  Phe Val Glu Ser Glu  Gly Val Asp Phe Glu  Lys Arg Leu 
    2390                 2395                 2400             


Gly Thr  Val Leu Pro Val Ile  Glu Lys Glu Ile Asp  Pro Glu Asn 
    2405                 2410                 2415             


Phe Lys  Asp Ile Met Glu Glu  Thr Glu Glu Lys Ala  Ala Asp Arg 
    2420                 2425                 2430             


Leu Leu  Phe Ser Phe Leu Thr  Leu Ile Thr Lys Leu  Ile Lys Glu 
    2435                 2440                 2445             


Cys Asn  Ile Ile Gln Phe Thr  Lys Pro Ala Glu Thr  Leu Ser Lys 
    2450                 2455                 2460             


Ile Trp  Ser His Val His Ser  His Leu Arg His Pro  His Asn Trp 
    2465                 2470                 2475             


Val Trp  Leu Thr Ala Ala Gln  Ile Phe Gly Leu Leu  Phe Ala Ser 
    2480                 2485                 2490             


Cys Gln  Pro Glu Glu Leu Ile  Gln Lys Trp Asn Thr  Lys Lys Thr 
    2495                 2500                 2505             


Lys Lys  His Leu Pro Glu Pro  Val Ala Ile Lys Phe  Leu Ala Ser 
    2510                 2515                 2520             


Asp Leu  Asp Gln Lys Met Lys  Ser Ile Ser Leu Ala  Ser Cys His 
    2525                 2530                 2535             


Gln Leu  His Ser Lys Phe Leu  Asp Gln Ser Leu Gly  Glu Gln Val 
    2540                 2545                 2550             


Val Lys  Asn Leu Leu Phe Ala  Ala Lys Val Leu Tyr  Leu Leu Glu 
    2555                 2560                 2565             


Leu Tyr  Cys Glu Asp Lys Gln  Ser Lys Ile Lys Glu  Asp Leu Glu 
    2570                 2575                 2580             


Glu Gln  Glu Ala Leu Glu Asp  Gly Val Ala Cys Ala  Asp Glu Lys 
    2585                 2590                 2595             


Ala Glu  Ser Asp Gly Glu Glu  Lys Glu Glu Val Lys  Glu Glu Leu 
    2600                 2605                 2610             


Gly Arg  Pro Ala Thr Leu Leu  Trp Leu Ile Gln Lys  Leu Ser Arg 
    2615                 2620                 2625             


Ile Ala  Lys Leu Glu Ala Ala  Tyr Ser Pro Arg Asn  Pro Leu Lys 
    2630                 2635                 2640             


Arg Thr  Cys Ile Phe Lys Phe  Leu Gly Ala Val Ala  Met Asp Leu 
    2645                 2650                 2655             


Gly Ile  Asp Lys Val Lys Pro  Tyr Leu Pro Met Ile  Ile Ala Pro 
    2660                 2665                 2670             


Leu Phe  Arg Glu Leu Asn Ser  Thr Tyr Ser Glu Gln  Asp Pro Leu 
    2675                 2680                 2685             


Leu Lys  Asn Leu Ser Gln Glu  Ile Ile Glu Leu Leu  Lys Lys Leu 
    2690                 2695                 2700             


Val Gly  Leu Glu Ser Phe Ser  Leu Ala Phe Ala Ser  Val Gln Lys 
    2705                 2710                 2715             


Gln Ala  Asn Glu Lys Arg Ala  Leu Arg Lys Lys Arg  Lys Ala Leu 
    2720                 2725                 2730             


Glu Phe  Val Thr Asn Pro Asp  Ile Ala Ala Lys Lys  Lys Met Lys 
    2735                 2740                 2745             


Lys His  Lys Asn Lys Ser Glu  Ala Lys Lys Arg Lys  Ile Glu Phe 
    2750                 2755                 2760             


Leu Arg  Pro Gly Tyr Lys Ala  Lys Arg Gln Lys Ser  His Ser Leu 
    2765                 2770                 2775             


Lys Asp  Leu Ala Met Val Glu  
    2780                 2785 


<210>  74
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Lys Lys Thr Arg Ser Thr Thr Leu Arg Arg Ala Trp Pro Ser Ser 
1               5                   10                  15      


Asp Phe Ser Asp Arg Ala Ser Asp Arg Met Arg Ser Arg Ser Glu Lys 
            20                  25                  30          


Asp Tyr Arg Leu His Lys Arg Phe Pro Ala Ala Phe Ala Pro Gln Ala 
        35                  40                  45              


Ser Arg Gly Tyr Met Thr Ser Gly Asp Val Ser Pro Ile Ser Met Ser 
    50                  55                  60                  


Pro Ile Ser Gln Ser Gln Phe Ile Pro Leu Gly Glu Ile Leu Cys Leu 
65                  70                  75                  80  


Ala Ile Ser Ala Met Asn Ser Ala Arg Lys Pro Val Thr Gln Glu Ala 
                85                  90                  95      


Leu Met Glu His Leu Thr Thr Cys Phe Pro Gly Val Pro Thr Pro Ser 
            100                 105                 110         


Gln Glu Ile Leu Arg His Thr Leu Asn Thr Leu Val Arg Glu Arg Lys 
        115                 120                 125             


Ile Tyr Pro Thr Pro Asp Gly Tyr Phe Ile Val Thr Pro Gln Thr Tyr 
    130                 135                 140                 


Phe Ile Thr Pro Ser Leu Ile Arg Thr Asn Ser Lys Trp Tyr His Leu 
145                 150                 155                 160 


Asp Glu Arg Ile Pro Asp Arg Ser Gln Cys Thr Ser Pro Gln Pro Gly 
                165                 170                 175     


Thr Ile Thr Pro Ser Ala Ser Gly Cys Val Arg Glu Arg Thr Leu Pro 
            180                 185                 190         


Arg Asn His Cys Asp Ser Cys His Cys Cys Arg Glu Asp Val His Ser 
        195                 200                 205             


Thr His Ala Pro Thr Leu Gln Arg Lys Ser Ala Lys Asp Cys Lys Asp 
    210                 215                 220                 


Pro Tyr Cys Pro Pro Ser Leu Cys Gln Val Pro Pro Thr Glu Lys Ser 
225                 230                 235                 240 


Lys Ser Thr Val Asn Phe Ser Tyr Lys Thr Glu Thr Leu Ser Lys Pro 
                245                 250                 255     


Lys Asp Ser Glu Lys Gln Ser Lys Lys Phe Gly Leu Lys Leu Phe Arg 
            260                 265                 270         


Leu Ser Phe Lys Lys Asp Lys Thr Lys Gln Leu Ala Asn Phe Ser Ala 
        275                 280                 285             


Gln Phe Pro Pro Glu Glu Trp Pro Leu Arg Asp Glu Asp Thr Pro Ala 
    290                 295                 300                 


Thr Ile Pro Arg Glu Val Glu Met Glu Ile Ile Arg Arg Ile Asn Pro 
305                 310                 315                 320 


Asp Leu Thr Val Glu Asn Val Met Arg His Thr Ala Leu Met Lys Lys 
                325                 330                 335     


Leu Glu Glu Glu Lys Ala Gln Arg Ser Lys Ala Gly Ser Ser Ala His 
            340                 345                 350         


His Ser Gly Arg Ser Lys Lys Ser Arg Thr His Arg Lys Ser His Gly 
        355                 360                 365             


Lys Ser Arg Ser His Ser Lys Thr Arg Val Ser Lys Gly Asp Pro Ser 
    370                 375                 380                 


Asp Gly Ser His Leu Asp Ile Pro Ala Glu Arg Glu Tyr Asp Phe Cys 
385                 390                 395                 400 


Asp Pro Leu Thr Arg Val Pro Arg Glu Gly Cys Phe Ile Ile Glu His 
                405                 410                 415     


Lys Gly Asp Asn Phe Ile Met His Ser Asn Thr Asn Val Leu Glu Ser 
            420                 425                 430         


His Phe Pro Met Thr Pro Glu Trp Asp Val Ser Gly Glu Leu Ala Lys 
        435                 440                 445             


Arg Arg Thr Glu Met Pro Phe Pro Glu Pro Ser Arg Gly Ser Ser His 
    450                 455                 460                 


Ser Lys Val His Arg Ser His Ser His Thr Gln Asp Arg Arg Ser Arg 
465                 470                 475                 480 


Asn Glu Arg Ser Asn Lys Ala Lys Glu Arg Ser Arg Ser Met Asp Asn 
                485                 490                 495     


Ser Lys Gly Pro Leu Gly Ala Ser Ser Leu Gly Thr Pro Glu Asp Leu 
            500                 505                 510         


Ala Glu Gly Cys Ser Gln Asp Asp Gln Thr Pro Ser Gln Ser Tyr Ile 
        515                 520                 525             


Asp Asp Ser Thr Leu Arg Pro Ala Gln Thr Val Ser Leu Gln Arg Ala 
    530                 535                 540                 


His Ile Ser Ser Thr Ser Tyr Lys Glu Val Cys Ile Pro Glu Ile Val 
545                 550                 555                 560 


Ser Gly Ser Lys Glu Pro Ser Ser Ala Cys Ser Leu Leu Glu Pro Gly 
                565                 570                 575     


Lys Pro Pro Glu Ser Leu Pro Ser Tyr Gly Glu Leu Asn Ser Cys Pro 
            580                 585                 590         


Thr Lys Thr Ala Thr Asp Asp Tyr Phe Gln Cys Asn Thr Ser Ser Glu 
        595                 600                 605             


Thr Val Leu Thr Ala Pro Ser Pro Leu Gly Lys Asn Lys Glu Asp His 
    610                 615                 620                 


Asp Thr Leu Thr Leu Ala Glu Gly Val Lys Lys Leu Ser Pro Ser Asp 
625                 630                 635                 640 


Arg Gln Val Pro His Ser Ser Arg Glu Pro Val Gly His Lys Glu Glu 
                645                 650                 655     


Ser Pro Lys Gly Pro Gly Gly Gly Pro Ala Ala Ser Gly Gly Val Ala 
            660                 665                 670         


Glu Gly Ile Ala Asn Gly Arg Leu Val Gln His His Gly Ala Glu Pro 
        675                 680                 685             


Ser Ser Leu Asp Lys Arg Lys Glu Ile Phe Ser Lys Asp Thr Leu Phe 
    690                 695                 700                 


Lys Pro Leu His Ser Thr Leu Ser Val Asn Ser Tyr His Lys Ser Ser 
705                 710                 715                 720 


Leu Ser Leu Leu Lys Ser His Pro Lys Thr Pro Ala Asp Thr Leu Pro 
                725                 730                 735     


Gly Arg Cys Glu Lys Leu Glu Pro Ser Leu Gly Thr Ser Ala Ala Gln 
            740                 745                 750         


Ala Met Pro Ala Ser Gln Arg Gln Gln Glu Ser Gly Gly Asn Gln Glu 
        755                 760                 765             


Ala Ser Phe Asp Tyr Tyr Asn Val Ser Asp Asp Asp Asp Ser Glu Glu 
    770                 775                 780                 


Gly Ala Asn Lys Asn Thr Glu Glu Glu Lys Asn Arg Glu Asp Val Gly 
785                 790                 795                 800 


Thr Met Gln Trp Leu Leu Glu Arg Glu Lys Glu Arg Asp Leu Gln Arg 
                805                 810                 815     


Lys Phe Glu Lys Asn Leu Thr Leu Leu Ala Pro Lys Glu Thr Asp Ser 
            820                 825                 830         


Ser Ser Asn Gln Arg Ala Thr His Ser Ala Arg Leu Asp Ser Met Asp 
        835                 840                 845             


Ser Ser Ser Ile Thr Val Asp Ser Gly Phe Asn Ser Pro Arg Thr Arg 
    850                 855                 860                 


Glu Ser Leu Ala Ser Asn Thr Ser Ser Ile Val Glu Ser Asn Arg Arg 
865                 870                 875                 880 


Gln Asn Pro Ala Leu Ser Pro Ala His Gly Gly Ala Gly Pro Ala Phe 
                885                 890                 895     


Asn Phe Arg Ala Ser Ala Glu Pro Pro Thr Asn Glu Ala Glu Lys Leu 
            900                 905                 910         


Gln Lys Pro Ser Asn Cys Leu Gln Ala Ser Val Thr Ser Val 
        915                 920                 925     


<210>  75
<211>  2999
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Gly Asn Glu Asn Ser Thr Ser Asp Asn Gln Gln Glu Asp Ser Val 
1               5                   10                  15      


Leu His Asn Val Ile Leu Trp Pro Pro Asn Pro Glu Pro Thr Gln Arg 
            20                  25                  30          


Thr Leu Ser Ala Gln Thr Pro Arg Ser Ala Gln Pro Pro Gly Asn Ser 
        35                  40                  45              


Gln Asn Ile Lys Arg Lys Gln Gln Asp Thr Pro Gly Ser Pro Asp His 
    50                  55                  60                  


Arg Asp Ala Ser Ser Ile Gly Ser Val Gly Leu Gly Gly Phe Cys Thr 
65                  70                  75                  80  


Ala Ser Glu Ser Ser Ala Ser Leu Asp Pro Cys Leu Val Ser Pro Glu 
                85                  90                  95      


Val Thr Glu Pro Arg Lys Asp Pro Gln Gly Ala Arg Gly Pro Glu Gly 
            100                 105                 110         


Ser Leu Leu Pro Ser Pro Pro Pro Ser Gln Glu Arg Glu His Pro Ser 
        115                 120                 125             


Ser Ser Met Pro Phe Ala Glu Cys Pro Pro Glu Gly Cys Leu Ala Ser 
    130                 135                 140                 


Pro Ala Ala Ala Pro Glu Asp Gly Pro Gln Thr Gln Ser Pro Arg Arg 
145                 150                 155                 160 


Glu Pro Ala Pro Asn Ala Pro Gly Asp Ile Ala Ala Ala Phe Pro Ala 
                165                 170                 175     


Glu Arg Asp Ser Ser Thr Pro Tyr Gln Glu Ile Ala Ala Val Pro Ser 
            180                 185                 190         


Ala Gly Arg Glu Arg Gln Pro Lys Glu Glu Gly Gln Lys Ser Ser Phe 
        195                 200                 205             


Ser Phe Ser Ser Gly Ile Asp Gln Ser Pro Gly Met Ser Pro Val Pro 
    210                 215                 220                 


Leu Arg Glu Pro Met Lys Ala Pro Leu Cys Gly Glu Gly Asp Gln Pro 
225                 230                 235                 240 


Gly Gly Phe Glu Ser Gln Glu Lys Glu Ala Ala Gly Gly Phe Pro Pro 
                245                 250                 255     


Ala Glu Ser Arg Gln Gly Val Ala Ser Val Gln Val Thr Pro Glu Ala 
            260                 265                 270         


Pro Ala Ala Ala Gln Gln Gly Thr Glu Ser Ser Ala Val Leu Glu Lys 
        275                 280                 285             


Ser Pro Leu Lys Pro Met Ala Pro Ile Pro Gln Asp Pro Ala Pro Arg 
    290                 295                 300                 


Ala Ser Asp Arg Glu Arg Gly Gln Gly Glu Ala Pro Pro Gln Tyr Leu 
305                 310                 315                 320 


Thr Asp Asp Leu Glu Phe Leu Arg Ala Cys His Leu Pro Arg Ser Asn 
                325                 330                 335     


Ser Gly Ala Ala Pro Glu Ala Glu Val Asn Ala Ala Ser Gln Glu Ser 
            340                 345                 350         


Cys Gln Gln Pro Val Gly Ala Tyr Leu Pro His Ala Glu Leu Pro Trp 
        355                 360                 365             


Gly Leu Pro Ser Pro Ala Leu Val Pro Glu Ala Gly Gly Ser Gly Lys 
    370                 375                 380                 


Glu Ala Leu Asp Thr Ile Asp Val Gln Gly His Pro Gln Thr Gly Met 
385                 390                 395                 400 


Arg Gly Thr Lys Pro Asn Gln Val Val Cys Val Ala Ala Gly Gly Gln 
                405                 410                 415     


Pro Glu Gly Gly Leu Pro Val Ser Pro Glu Pro Ser Leu Leu Thr Pro 
            420                 425                 430         


Thr Glu Glu Ala His Pro Ala Ser Ser Leu Ala Ser Phe Pro Ala Ala 
        435                 440                 445             


Gln Ile Pro Ile Ala Val Glu Glu Pro Gly Ser Ser Ser Arg Glu Ser 
    450                 455                 460                 


Val Ser Lys Ala Gly Met Pro Val Ser Ala Asp Ala Ala Lys Glu Val 
465                 470                 475                 480 


Val Asp Ala Gly Leu Val Gly Leu Glu Arg Gln Val Ser Asp Leu Gly 
                485                 490                 495     


Ser Lys Gly Glu His Pro Glu Gly Asp Pro Gly Glu Val Pro Ala Pro 
            500                 505                 510         


Ser Pro Gln Glu Arg Gly Glu His Leu Asn Thr Glu Gln Ser His Glu 
        515                 520                 525             


Val Gln Pro Gly Val Pro Pro Pro Pro Leu Pro Lys Glu Gln Ser His 
    530                 535                 540                 


Glu Val Gln Pro Gly Ala Pro Pro Pro Pro Leu Pro Lys Ala Pro Ser 
545                 550                 555                 560 


Glu Ser Ala Arg Gly Pro Pro Gly Pro Thr Asp Gly Ala Lys Val His 
                565                 570                 575     


Glu Asp Ser Thr Ser Pro Ala Val Ala Lys Glu Gly Ser Arg Ser Pro 
            580                 585                 590         


Gly Asp Ser Pro Gly Gly Lys Glu Glu Ala Pro Glu Pro Pro Asp Gly 
        595                 600                 605             


Gly Asp Pro Gly Asn Leu Gln Gly Glu Asp Ser Gln Ala Phe Ser Ser 
    610                 615                 620                 


Lys Arg Asp Pro Glu Val Gly Lys Asp Glu Leu Ser Lys Pro Ser Ser 
625                 630                 635                 640 


Asp Ala Glu Ser Arg Asp His Pro Ser Ser His Ser Ala Gln Pro Pro 
                645                 650                 655     


Arg Lys Gly Gly Ala Gly His Thr Asp Gly Pro His Ser Gln Thr Ala 
            660                 665                 670         


Glu Ala Asp Ala Ser Gly Leu Pro His Lys Leu Gly Glu Glu Asp Pro 
        675                 680                 685             


Val Leu Pro Pro Val Pro Asp Gly Ala Gly Glu Pro Thr Val Pro Glu 
    690                 695                 700                 


Gly Ala Ile Trp Glu Gly Ser Gly Leu Gln Pro Lys Cys Pro Asp Thr 
705                 710                 715                 720 


Leu Gln Ser Arg Glu Gly Leu Gly Arg Met Glu Ser Phe Leu Thr Leu 
                725                 730                 735     


Glu Ser Glu Lys Ser Asp Phe Pro Pro Thr Pro Val Ala Glu Val Ala 
            740                 745                 750         


Pro Lys Ala Gln Glu Gly Glu Ser Thr Leu Glu Ile Arg Lys Met Gly 
        755                 760                 765             


Ser Cys Asp Gly Glu Gly Leu Leu Thr Ser Pro Asp Gln Pro Arg Gly 
    770                 775                 780                 


Pro Ala Cys Asp Ala Ser Arg Gln Glu Phe His Ala Gly Val Pro His 
785                 790                 795                 800 


Pro Pro Gln Gly Glu Asn Leu Ala Ala Asp Leu Gly Leu Thr Ala Leu 
                805                 810                 815     


Ile Leu Asp Gln Asp Gln Gln Gly Ile Pro Ser Cys Pro Gly Glu Gly 
            820                 825                 830         


Trp Ile Arg Gly Ala Ala Ser Glu Trp Pro Leu Leu Ser Ser Glu Lys 
        835                 840                 845             


His Leu Gln Pro Ser Gln Ala Gln Pro Glu Thr Ser Ile Phe Asp Val 
    850                 855                 860                 


Leu Lys Glu Gln Ala Gln Pro Pro Glu Asn Gly Lys Glu Thr Ser Pro 
865                 870                 875                 880 


Ser His Pro Gly Phe Lys Asp Gln Gly Ala Asp Ser Ser Gln Ile His 
                885                 890                 895     


Val Pro Val Glu Pro Gln Glu Asp Asn Asn Leu Pro Thr His Gly Gly 
            900                 905                 910         


Gln Glu Gln Ala Leu Gly Ser Glu Leu Gln Ser Gln Leu Pro Lys Gly 
        915                 920                 925             


Thr Leu Ser Asp Thr Pro Thr Ser Ser Pro Thr Asp Met Val Trp Glu 
    930                 935                 940                 


Ser Ser Leu Thr Glu Glu Ser Glu Leu Ser Ala Pro Thr Arg Gln Lys 
945                 950                 955                 960 


Leu Pro Ala Leu Gly Glu Lys Arg Pro Glu Gly Ala Cys Gly Asp Gly 
                965                 970                 975     


Gln Ser Ser Arg Val Ser Pro Pro Ala Ala Asp Val Leu Lys Asp Phe 
            980                 985                 990         


Ser Leu Ala Gly Asn Phe Ser Arg  Lys Glu Thr Cys Cys  Thr Gly Gln 
        995                 1000                 1005             


Gly Pro  Asn Lys Ser Gln Gln  Ala Leu Ala Asp Ala  Leu Glu Glu 
    1010                 1015                 1020             


Gly Ser  Gln His Glu Glu Ala  Cys Gln Arg His Pro  Gly Ala Ser 
    1025                 1030                 1035             


Glu Ala  Ala Asp Gly Cys Ser  Pro Leu Trp Gly Leu  Ser Lys Arg 
    1040                 1045                 1050             


Glu Met  Ala Ser Gly Asn Thr  Gly Glu Ala Pro Pro  Cys Gln Pro 
    1055                 1060                 1065             


Asp Ser  Val Ala Leu Leu Asp  Ala Val Pro Cys Leu  Pro Ala Leu 
    1070                 1075                 1080             


Ala Pro  Ala Ser Pro Gly Val  Thr Pro Thr Gln Asp  Ala Pro Glu 
    1085                 1090                 1095             


Thr Glu  Ala Cys Asp Glu Thr  Gln Glu Gly Arg Gln  Gln Pro Val 
    1100                 1105                 1110             


Pro Ala  Pro Gln Gln Lys Met  Glu Cys Trp Ala Thr  Ser Asp Ala 
    1115                 1120                 1125             


Glu Ser  Pro Lys Leu Leu Ala  Ser Phe Pro Ser Ala  Gly Glu Gln 
    1130                 1135                 1140             


Gly Gly  Glu Ala Gly Ala Ala  Glu Thr Gly Gly Ser  Ala Gly Ala 
    1145                 1150                 1155             


Gly Asp  Pro Gly Lys Gln Gln  Ala Pro Glu Lys Pro  Gly Glu Ala 
    1160                 1165                 1170             


Thr Leu  Ser Cys Gly Leu Leu  Gln Thr Glu His Cys  Leu Thr Ser 
    1175                 1180                 1185             


Gly Glu  Glu Ala Ser Thr Ser  Ala Leu Arg Glu Ser  Cys Gln Ala 
    1190                 1195                 1200             


Glu His  Pro Met Ala Ser Cys  Gln Asp Ala Leu Leu  Pro Ala Arg 
    1205                 1210                 1215             


Glu Leu  Gly Gly Ile Pro Arg  Ser Thr Met Asp Phe  Ser Thr His 
    1220                 1225                 1230             


Gln Ala  Val Pro Asp Pro Lys  Glu Leu Leu Leu Ser  Gly Pro Pro 
    1235                 1240                 1245             


Glu Val  Ala Ala Pro Asp Thr  Pro Tyr Leu His Val  Asp Ser Ala 
    1250                 1255                 1260             


Ala Gln  Arg Gly Ala Glu Asp  Ser Gly Val Lys Ala  Val Ser Ser 
    1265                 1270                 1275             


Ala Asp  Pro Arg Ala Pro Gly  Glu Ser Pro Cys Pro  Val Gly Glu 
    1280                 1285                 1290             


Pro Pro  Leu Ala Leu Glu Asn  Ala Ala Ser Leu Lys  Leu Phe Ala 
    1295                 1300                 1305             


Gly Ser  Leu Ala Pro Leu Leu  Gln Pro Gly Ala Ala  Gly Gly Glu 
    1310                 1315                 1320             


Ile Pro  Ala Val Gln Ala Ser  Ser Gly Ser Pro Lys  Ala Arg Thr 
    1325                 1330                 1335             


Thr Glu  Gly Pro Val Asp Ser  Met Pro Cys Leu Asp  Arg Met Pro 
    1340                 1345                 1350             


Leu Leu  Ala Lys Gly Lys Gln  Ala Thr Gly Glu Glu  Lys Ala Ala 
    1355                 1360                 1365             


Thr Ala  Pro Gly Ala Gly Ala  Lys Ala Ser Gly Glu  Gly Met Ala 
    1370                 1375                 1380             


Gly Asp  Ala Ala Gly Glu Thr  Glu Gly Ser Met Glu  Arg Met Gly 
    1385                 1390                 1395             


Glu Pro  Ser Gln Asp Pro Lys  Gln Gly Thr Ser Gly  Gly Val Asp 
    1400                 1405                 1410             


Thr Ser  Ser Glu Gln Ile Ala  Thr Leu Thr Gly Phe  Pro Asp Phe 
    1415                 1420                 1425             


Arg Glu  His Ile Ala Lys Ile  Phe Glu Lys Pro Val  Leu Gly Ala 
    1430                 1435                 1440             


Leu Ala  Thr Pro Gly Glu Lys  Ala Gly Ala Gly Arg  Ser Ala Val 
    1445                 1450                 1455             


Gly Lys  Asp Leu Thr Arg Pro  Leu Gly Pro Glu Lys  Leu Leu Asp 
    1460                 1465                 1470             


Gly Pro  Pro Gly Val Asp Val  Thr Leu Leu Pro Ala  Pro Pro Ala 
    1475                 1480                 1485             


Arg Leu  Gln Val Glu Lys Lys  Gln Gln Leu Ala Gly  Glu Ala Glu 
    1490                 1495                 1500             


Ile Ser  His Leu Ala Leu Gln  Asp Pro Ala Ser Asp  Lys Leu Leu 
    1505                 1510                 1515             


Gly Pro  Ala Gly Leu Thr Trp  Glu Arg Asn Leu Pro  Gly Ala Gly 
    1520                 1525                 1530             


Val Gly  Lys Glu Met Ala Gly  Val Pro Pro Thr Leu  Arg Glu Asp 
    1535                 1540                 1545             


Glu Arg  Pro Glu Gly Pro Gly  Ala Ala Trp Pro Gly  Leu Glu Gly 
    1550                 1555                 1560             


Gln Ala  Tyr Ser Gln Leu Glu  Arg Ser Arg Gln Glu  Leu Ala Ser 
    1565                 1570                 1575             


Gly Leu  Pro Ser Pro Ala Ala  Thr Gln Glu Leu Pro  Val Glu Arg 
    1580                 1585                 1590             


Ala Ala  Ala Phe Gln Val Ala  Pro His Ser His Gly  Glu Glu Ala 
    1595                 1600                 1605             


Val Ala  Gln Asp Arg Ile Pro  Ser Gly Lys Gln His  Gln Glu Thr 
    1610                 1615                 1620             


Ser Ala  Cys Asp Ser Pro His  Gly Glu Asp Gly Pro  Gly Asp Phe 
    1625                 1630                 1635             


Ala His  Thr Gly Val Pro Gly  His Val Pro Arg Ser  Thr Cys Ala 
    1640                 1645                 1650             


Pro Ser  Pro Gln Arg Glu Val  Leu Thr Val Pro Glu  Ala Asn Ser 
    1655                 1660                 1665             


Glu Pro  Trp Thr Leu Asp Thr  Leu Gly Gly Glu Arg  Arg Pro Gly 
    1670                 1675                 1680             


Val Thr  Ala Gly Ile Leu Glu  Met Arg Asn Ala Leu  Gly Asn Gln 
    1685                 1690                 1695             


Ser Thr  Pro Ala Pro Pro Thr  Gly Glu Val Ala Asp  Thr Pro Leu 
    1700                 1705                 1710             


Glu Pro  Gly Lys Val Ala Gly  Ala Ala Gly Glu Ala  Glu Gly Asp 
    1715                 1720                 1725             


Ile Thr  Leu Ser Thr Ala Glu  Thr Gln Ala Cys Ala  Ser Gly Asp 
    1730                 1735                 1740             


Leu Pro  Glu Ala Gly Thr Thr  Arg Thr Phe Ser Val  Val Ala Gly 
    1745                 1750                 1755             


Asp Leu  Val Leu Pro Gly Ser  Cys Gln Asp Pro Ala  Cys Ser Asp 
    1760                 1765                 1770             


Lys Ala  Pro Gly Met Glu Gly  Thr Ala Ala Leu His  Gly Asp Ser 
    1775                 1780                 1785             


Pro Ala  Arg Pro Gln Gln Ala  Lys Glu Gln Pro Gly  Pro Glu Arg 
    1790                 1795                 1800             


Pro Ile  Pro Ala Gly Asp Gly  Lys Val Cys Val Ser  Ser Pro Pro 
    1805                 1810                 1815             


Glu Pro  Asp Glu Thr His Asp  Pro Lys Leu Gln His  Leu Ala Pro 
    1820                 1825                 1830             


Glu Glu  Leu His Thr Asp Arg  Glu Ser Pro Arg Pro  Gly Pro Ser 
    1835                 1840                 1845             


Met Leu  Pro Ser Val Pro Lys  Lys Asp Ala Pro Arg  Val Met Asp 
    1850                 1855                 1860             


Lys Val  Thr Ser Asp Glu Thr  Arg Gly Ala Glu Gly  Thr Glu Ser 
    1865                 1870                 1875             


Ser Pro  Val Ala Asp Asp Ile  Ile Gln Pro Ala Ala  Pro Ala Asp 
    1880                 1885                 1890             


Leu Glu  Ser Pro Thr Leu Ala  Ala Ser Ser Tyr His  Gly Asp Val 
    1895                 1900                 1905             


Val Gly  Gln Val Ser Thr Asp  Leu Ile Ala Gln Ser  Ile Ser Pro 
    1910                 1915                 1920             


Ala Ala  Ala His Ala Gly Leu  Pro Pro Ser Ala Ala  Glu His Ile 
    1925                 1930                 1935             


Val Ser  Pro Ser Ala Pro Ala  Gly Asp Arg Val Glu  Ala Ser Thr 
    1940                 1945                 1950             


Pro Ser  Cys Pro Asp Pro Ala  Lys Asp Leu Ser Arg  Ser Ser Asp 
    1955                 1960                 1965             


Ser Glu  Glu Ala Phe Glu Thr  Pro Glu Ser Thr Thr  Pro Val Lys 
    1970                 1975                 1980             


Ala Pro  Pro Ala Pro Pro Pro  Pro Pro Pro Glu Val  Ile Pro Glu 
    1985                 1990                 1995             


Pro Glu  Val Ser Thr Gln Pro  Pro Pro Glu Glu Pro  Gly Cys Gly 
    2000                 2005                 2010             


Ser Glu  Thr Val Pro Val Pro  Asp Gly Pro Arg Ser  Asp Ser Val 
    2015                 2020                 2025             


Glu Gly  Ser Pro Phe Arg Pro  Pro Ser His Ser Phe  Ser Ala Val 
    2030                 2035                 2040             


Phe Asp  Glu Asp Lys Pro Ile  Ala Ser Ser Gly Thr  Tyr Asn Leu 
    2045                 2050                 2055             


Asp Phe  Asp Asn Ile Glu Leu  Val Asp Thr Phe Gln  Thr Leu Glu 
    2060                 2065                 2070             


Pro Arg  Ala Ser Asp Ala Lys  Asn Gln Glu Gly Lys  Val Asn Thr 
    2075                 2080                 2085             


Arg Arg  Lys Ser Thr Asp Ser  Val Pro Ile Ser Lys  Ser Thr Leu 
    2090                 2095                 2100             


Ser Arg  Ser Leu Ser Leu Gln  Ala Ser Asp Phe Asp  Gly Ala Ser 
    2105                 2110                 2115             


Ser Ser  Gly Asn Pro Glu Ala  Val Ala Leu Ala Pro  Asp Ala Tyr 
    2120                 2125                 2130             


Ser Thr  Gly Ser Ser Ser Ala  Ser Ser Thr Leu Lys  Arg Thr Lys 
    2135                 2140                 2145             


Lys Pro  Arg Pro Pro Ser Leu  Lys Lys Lys Gln Thr  Thr Lys Lys 
    2150                 2155                 2160             


Pro Thr  Glu Thr Pro Pro Val  Lys Glu Thr Gln Gln  Glu Pro Asp 
    2165                 2170                 2175             


Glu Glu  Ser Leu Val Pro Ser  Gly Glu Asn Leu Ala  Ser Glu Thr 
    2180                 2185                 2190             


Lys Thr  Glu Ser Ala Lys Thr  Glu Gly Pro Ser Pro  Ala Leu Leu 
    2195                 2200                 2205             


Glu Glu  Thr Pro Leu Glu Pro  Ala Val Gly Pro Lys  Ala Ala Cys 
    2210                 2215                 2220             


Pro Leu  Asp Ser Glu Ser Ala  Glu Gly Val Val Pro  Pro Ala Ser 
    2225                 2230                 2235             


Gly Gly  Gly Arg Val Gln Asn  Ser Pro Pro Val Gly  Arg Lys Thr 
    2240                 2245                 2250             


Leu Pro  Leu Thr Thr Ala Pro  Glu Ala Gly Glu Val  Thr Pro Ser 
    2255                 2260                 2265             


Asp Ser  Gly Gly Gln Glu Asp  Ser Pro Ala Lys Gly  Leu Ser Val 
    2270                 2275                 2280             


Arg Leu  Glu Phe Asp Tyr Ser  Glu Asp Lys Ser Ser  Trp Asp Asn 
    2285                 2290                 2295             


Gln Gln  Glu Asn Pro Pro Pro  Thr Lys Lys Ile Gly  Lys Lys Pro 
    2300                 2305                 2310             


Val Ala  Lys Met Pro Leu Arg  Arg Pro Lys Met Lys  Lys Thr Pro 
    2315                 2320                 2325             


Glu Lys  Leu Asp Asn Thr Pro  Ala Ser Pro Pro Arg  Ser Pro Ala 
    2330                 2335                 2340             


Glu Pro  Asn Asp Ile Pro Ile  Ala Lys Gly Thr Tyr  Thr Phe Asp 
    2345                 2350                 2355             


Ile Asp  Lys Trp Asp Asp Pro  Asn Phe Asn Pro Phe  Ser Ser Thr 
    2360                 2365                 2370             


Ser Lys  Met Gln Glu Ser Pro  Lys Leu Pro Gln Gln  Ser Tyr Asn 
    2375                 2380                 2385             


Phe Asp  Pro Asp Thr Cys Asp  Glu Ser Val Asp Pro  Phe Lys Thr 
    2390                 2395                 2400             


Ser Ser  Lys Thr Pro Ser Ser  Pro Ser Lys Ser Pro  Ala Ser Phe 
    2405                 2410                 2415             


Glu Ile  Pro Ala Ser Ala Met  Glu Ala Asn Gly Val  Asp Gly Asp 
    2420                 2425                 2430             


Gly Leu  Asn Lys Pro Ala Lys  Lys Lys Lys Thr Pro  Leu Lys Thr 
    2435                 2440                 2445             


Asp Thr  Phe Arg Val Lys Lys  Ser Pro Lys Arg Ser  Pro Leu Ser 
    2450                 2455                 2460             


Asp Pro  Pro Ser Gln Asp Pro  Thr Pro Ala Ala Thr  Pro Glu Thr 
    2465                 2470                 2475             


Pro Pro  Val Ile Ser Ala Val  Val His Ala Thr Asp  Glu Glu Lys 
    2480                 2485                 2490             


Leu Ala  Val Thr Asn Gln Lys  Trp Thr Cys Met Thr  Val Asp Leu 
    2495                 2500                 2505             


Glu Ala  Asp Lys Gln Asp Tyr  Pro Gln Pro Ser Asp  Leu Ser Thr 
    2510                 2515                 2520             


Phe Val  Asn Glu Thr Lys Phe  Ser Ser Pro Thr Glu  Gly Lys Gln 
    2525                 2530                 2535             


Leu Cys  Ser Gln Leu Asp Pro  His Ser Ala Ser Glu  Asn Pro Ala 
    2540                 2545                 2550             


Pro Arg  Glu Pro Lys Ala Arg  Arg Glu Thr Ser Gln  Pro Glu Leu 
    2555                 2560                 2565             


Asp Tyr  Arg Asn Ser Tyr Glu  Ile Glu Tyr Met Glu  Lys Ile Gly 
    2570                 2575                 2580             


Ser Ser  Leu Pro Gln Asp Asp  Asp Ala Pro Lys Lys  Gln Ala Leu 
    2585                 2590                 2595             


Tyr Leu  Met Phe Asp Thr Ser  Gln Glu Ser Pro Val  Lys Ser Ser 
    2600                 2605                 2610             


Pro Val  Arg Met Ser Glu Ser  Pro Thr Pro Cys Ser  Gly Ser Ser 
    2615                 2620                 2625             


Phe Glu  Glu Thr Glu Ala Leu  Val Asn Thr Ala Ala  Lys Asn Gln 
    2630                 2635                 2640             


His Pro  Val Pro Arg Gly Leu  Ala Pro Asn Gln Glu  Ser His Leu 
    2645                 2650                 2655             


Gln Val  Pro Glu Lys Ser Ser  Gln Lys Glu Leu Glu  Ala Met Gly 
    2660                 2665                 2670             


Leu Gly  Thr Pro Ser Glu Ala  Ile Glu Ile Thr Ala  Pro Glu Gly 
    2675                 2680                 2685             


Ser Phe  Ala Ser Ala Asp Ala  Leu Leu Ser Arg Leu  Ala His Pro 
    2690                 2695                 2700             


Val Ser  Leu Cys Gly Ala Leu  Asp Tyr Leu Glu Pro  Asp Leu Ala 
    2705                 2710                 2715             


Glu Lys  Asn Pro Pro Leu Phe  Ala Gln Lys Leu Gln  Glu Glu Leu 
    2720                 2725                 2730             


Glu Phe  Ala Ile Met Arg Ile  Glu Ala Leu Lys Leu  Ala Arg Gln 
    2735                 2740                 2745             


Ile Ala  Leu Ala Ser Arg Ser  His Gln Asp Ala Lys  Arg Glu Ala 
    2750                 2755                 2760             


Ala His  Pro Thr Asp Val Ser  Ile Ser Lys Thr Ala  Leu Tyr Ser 
    2765                 2770                 2775             


Arg Ile  Gly Thr Ala Glu Val  Glu Lys Pro Ala Gly  Leu Leu Phe 
    2780                 2785                 2790             


Gln Gln  Pro Asp Leu Asp Ser  Ala Leu Gln Ile Ala  Arg Ala Glu 
    2795                 2800                 2805             


Ile Ile  Thr Lys Glu Arg Glu  Val Ser Glu Trp Lys  Asp Lys Tyr 
    2810                 2815                 2820             


Glu Glu  Ser Arg Arg Glu Val  Met Glu Met Arg Lys  Ile Val Ala 
    2825                 2830                 2835             


Glu Tyr  Glu Lys Thr Ile Ala  Gln Met Ile Glu Asp  Glu Gln Arg 
    2840                 2845                 2850             


Glu Lys  Ser Val Ser His Gln  Thr Val Gln Gln Leu  Val Leu Glu 
    2855                 2860                 2865             


Lys Glu  Gln Ala Leu Ala Asp  Leu Asn Ser Val Glu  Lys Ser Leu 
    2870                 2875                 2880             


Ala Asp  Leu Phe Arg Arg Tyr  Glu Lys Met Lys Glu  Val Leu Glu 
    2885                 2890                 2895             


Gly Phe  Arg Lys Asn Glu Glu  Val Leu Lys Arg Cys  Ala Gln Glu 
    2900                 2905                 2910             


Tyr Leu  Ser Arg Val Lys Lys  Glu Glu Gln Arg Tyr  Gln Ala Leu 
    2915                 2920                 2925             


Lys Val  His Ala Glu Glu Lys  Leu Asp Arg Ala Asn  Ala Glu Ile 
    2930                 2935                 2940             


Ala Gln  Val Arg Gly Lys Ala  Gln Gln Glu Gln Ala  Ala His Gln 
    2945                 2950                 2955             


Ala Ser  Leu Arg Lys Glu Gln  Leu Arg Val Asp Ala  Leu Glu Arg 
    2960                 2965                 2970             


Thr Leu  Glu Gln Lys Asn Lys  Glu Ile Glu Glu Leu  Thr Lys Ile 
    2975                 2980                 2985             


Cys Asp  Glu Leu Ile Ala Lys  Met Gly Lys Ser 
    2990                 2995                 


<210>  76
<211>  914
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Asn Ile Asn Leu Lys Glu Ile Thr Leu Ile Val Gly Val Val 
1               5                   10                  15      


Thr Ala Cys Tyr Trp Asn Ser Leu Phe Cys Gly Phe Val Phe Asp Asp 
            20                  25                  30          


Val Ser Ala Ile Leu Asp Asn Lys Asp Leu His Pro Ser Thr Pro Leu 
        35                  40                  45              


Lys Thr Leu Phe Gln Asn Asp Phe Trp Gly Thr Pro Met Ser Glu Glu 
    50                  55                  60                  


Arg Ser His Lys Ser Tyr Arg Pro Leu Thr Val Leu Thr Phe Arg Leu 
65                  70                  75                  80  


Asn Tyr Leu Leu Ser Glu Leu Lys Pro Met Ser Tyr His Leu Leu Asn 
                85                  90                  95      


Met Ile Phe His Ala Val Val Ser Val Ile Phe Leu Lys Val Cys Lys 
            100                 105                 110         


Leu Phe Leu Asp Asn Lys Ser Ser Val Ile Ala Ser Leu Leu Phe Ala 
        115                 120                 125             


Val His Pro Ile His Thr Glu Ala Val Thr Gly Val Val Gly Arg Ala 
    130                 135                 140                 


Glu Leu Leu Ser Ser Ile Phe Phe Leu Ala Ala Phe Leu Ser Tyr Thr 
145                 150                 155                 160 


Arg Ser Lys Gly Pro Asp Asn Ser Ile Ile Trp Thr Pro Ile Ala Leu 
                165                 170                 175     


Thr Val Phe Leu Val Ala Val Ala Thr Leu Cys Lys Glu Gln Gly Ile 
            180                 185                 190         


Thr Val Val Gly Ile Cys Cys Val Tyr Glu Val Phe Ile Ala Gln Gly 
        195                 200                 205             


Tyr Thr Leu Pro Leu Leu Cys Thr Thr Ala Gly Gln Phe Leu Arg Gly 
    210                 215                 220                 


Lys Gly Ser Ile Pro Phe Ser Met Leu Gln Thr Leu Val Lys Leu Ile 
225                 230                 235                 240 


Val Leu Met Phe Ser Thr Leu Leu Leu Val Val Ile Arg Val Gln Val 
                245                 250                 255     


Ile Gln Ser Gln Leu Pro Val Phe Thr Arg Phe Asp Asn Pro Ala Ala 
            260                 265                 270         


Val Ser Pro Thr Pro Thr Arg Gln Leu Thr Phe Asn Tyr Leu Leu Pro 
        275                 280                 285             


Val Asn Ala Trp Leu Leu Leu Asn Pro Ser Glu Leu Cys Cys Asp Trp 
    290                 295                 300                 


Thr Met Gly Thr Ile Pro Leu Ile Glu Ser Leu Leu Asp Ile Arg Asn 
305                 310                 315                 320 


Leu Ala Thr Phe Thr Phe Phe Cys Phe Leu Gly Met Leu Gly Val Phe 
                325                 330                 335     


Ser Ile Arg Tyr Ser Gly Asp Ser Ser Lys Thr Val Leu Met Ala Leu 
            340                 345                 350         


Cys Leu Met Ala Leu Pro Phe Ile Pro Ala Ser Asn Leu Phe Phe Pro 
        355                 360                 365             


Val Gly Phe Val Val Ala Glu Arg Val Leu Tyr Val Pro Ser Met Gly 
    370                 375                 380                 


Phe Cys Ile Leu Val Ala His Gly Trp Gln Lys Ile Ser Thr Lys Ser 
385                 390                 395                 400 


Val Phe Lys Lys Leu Ser Trp Ile Cys Leu Ser Met Val Ile Leu Thr 
                405                 410                 415     


His Ser Leu Lys Thr Phe His Arg Asn Trp Asp Trp Glu Ser Glu Tyr 
            420                 425                 430         


Thr Leu Phe Met Ser Ala Leu Lys Val Asn Lys Asn Asn Ala Lys Leu 
        435                 440                 445             


Trp Asn Asn Val Gly His Ala Leu Glu Asn Glu Lys Asn Phe Glu Arg 
    450                 455                 460                 


Ala Leu Lys Tyr Phe Leu Gln Ala Thr His Val Gln Pro Asp Asp Ile 
465                 470                 475                 480 


Gly Ala His Met Asn Val Gly Arg Thr Tyr Lys Asn Leu Asn Arg Thr 
                485                 490                 495     


Lys Glu Ala Glu Glu Ser Tyr Met Met Ala Lys Ser Leu Met Pro Gln 
            500                 505                 510         


Ile Ile Pro Gly Lys Lys Tyr Ala Ala Arg Ile Ala Pro Asn His Leu 
        515                 520                 525             


Asn Val Tyr Ile Asn Leu Ala Asn Leu Ile Arg Ala Asn Glu Ser Arg 
    530                 535                 540                 


Leu Glu Glu Ala Asp Gln Leu Tyr Arg Gln Ala Ile Ser Met Arg Pro 
545                 550                 555                 560 


Asp Phe Lys Gln Ala Tyr Ile Ser Arg Gly Glu Leu Leu Leu Lys Met 
                565                 570                 575     


Asn Lys Pro Leu Lys Ala Lys Glu Ala Tyr Leu Lys Ala Leu Glu Leu 
            580                 585                 590         


Asp Arg Asn Asn Ala Asp Leu Trp Tyr Asn Leu Ala Ile Val His Ile 
        595                 600                 605             


Glu Leu Lys Glu Pro Asn Glu Ala Leu Lys Asn Phe Asn Arg Ala Leu 
    610                 615                 620                 


Glu Leu Asn Pro Lys His Lys Leu Ala Leu Phe Asn Ser Ala Ile Val 
625                 630                 635                 640 


Met Gln Glu Ser Gly Glu Val Lys Leu Arg Pro Glu Ala Arg Lys Arg 
                645                 650                 655     


Leu Leu Ser Tyr Ile Asn Glu Glu Pro Leu Asp Ala Asn Gly Tyr Phe 
            660                 665                 670         


Asn Leu Gly Met Leu Ala Met Asp Asp Lys Lys Asp Asn Glu Ala Glu 
        675                 680                 685             


Ile Trp Met Lys Lys Ala Ile Lys Leu Gln Ala Asp Phe Arg Ser Ala 
    690                 695                 700                 


Leu Phe Asn Leu Ala Leu Leu Tyr Ser Gln Thr Ala Lys Glu Leu Lys 
705                 710                 715                 720 


Ala Leu Pro Ile Leu Glu Glu Leu Leu Arg Tyr Tyr Pro Asp His Ile 
                725                 730                 735     


Lys Gly Leu Ile Leu Lys Gly Asp Ile Leu Met Asn Gln Lys Lys Asp 
            740                 745                 750         


Ile Leu Gly Ala Lys Lys Cys Phe Glu Arg Ile Leu Glu Met Asp Pro 
        755                 760                 765             


Ser Asn Val Gln Gly Lys His Asn Leu Cys Val Val Tyr Phe Glu Glu 
    770                 775                 780                 


Lys Asp Leu Leu Lys Ala Glu Arg Cys Leu Leu Glu Thr Leu Ala Leu 
785                 790                 795                 800 


Ala Pro His Glu Glu Tyr Ile Gln Arg His Leu Asn Ile Val Arg Asp 
                805                 810                 815     


Lys Ile Ser Ser Ser Ser Phe Ile Glu Pro Ile Phe Pro Thr Ser Lys 
            820                 825                 830         


Ile Ser Ser Val Glu Gly Lys Lys Ile Pro Thr Glu Ser Val Lys Glu 
        835                 840                 845             


Ile Arg Gly Glu Ser Arg Gln Thr Gln Ile Val Lys Thr Ser Asp Asn 
    850                 855                 860                 


Lys Ser Gln Ser Lys Ser Asn Lys Gln Leu Gly Lys Asn Gly Asp Glu 
865                 870                 875                 880 


Glu Thr Pro His Lys Thr Thr Lys Asp Ile Lys Glu Ile Glu Lys Lys 
                885                 890                 895     


Arg Val Ala Ala Leu Lys Arg Leu Glu Glu Ile Glu Arg Ile Leu Asn 
            900                 905                 910         


Gly Glu 
        


<210>  77
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Ser Gly Val Gly Ala Ala Phe Glu Glu Leu Pro His Asp Gly 
1               5                   10                  15      


Thr Cys Asp Glu Cys Glu Pro Asp Glu Ala Pro Gly Ala Glu Glu Val 
            20                  25                  30          


Cys Arg Glu Cys Gly Phe Cys Tyr Cys Arg Arg His Ala Glu Ala His 
        35                  40                  45              


Arg Gln Lys Phe Leu Ser His His Leu Ala Glu Tyr Val His Gly Ser 
    50                  55                  60                  


Gln Ala Trp Thr Pro Pro Ala Asp Gly Glu Gly Ala Gly Lys Glu Glu 
65                  70                  75                  80  


Ala Glu Val Lys Val Glu Gln Glu Arg Glu Ile Glu Ser Glu Ala Gly 
                85                  90                  95      


Glu Glu Ser Glu Ser Glu Glu Glu Ser Glu Ser Glu Glu Glu Ser Glu 
            100                 105                 110         


Thr Glu Glu Glu Ser Glu Asp Glu Ser Asp Glu Glu Ser Glu Glu Asp 
        115                 120                 125             


Ser Glu Glu Glu Met Glu Asp Glu Gln Glu Ser Glu Ala Glu Glu Asp 
    130                 135                 140                 


Asn Gln Glu Glu Gly Glu Ser Glu Ala Glu Gly Glu Thr Glu Ala Glu 
145                 150                 155                 160 


Ser Glu Phe Asp Pro Glu Ile Glu Met Glu Ala Glu Arg Val Ala Lys 
                165                 170                 175     


Arg Lys Cys Pro Asp His Gly Leu Asp Leu Ser Thr Tyr Cys Gln Glu 
            180                 185                 190         


Asp Arg Gln Leu Ile Cys Val Leu Cys Pro Val Ile Gly Ala His Gln 
        195                 200                 205             


Gly His Gln Leu Ser Thr Leu Asp Glu Ala Phe Glu Glu Leu Arg Ser 
    210                 215                 220                 


Lys Asp Ser Gly Gly Leu Lys Ala Ala Met Ile Glu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Lys Phe Lys Ser Ser Asp Pro Lys Val Thr Arg Asp Gln Met Lys 
                245                 250                 255     


Met Phe Ile Gln Gln Glu Phe Lys Lys Val Gln Lys Val Ile Ala Asp 
            260                 265                 270         


Glu Glu Gln Lys Ala Leu His Leu Val Asp Ile Gln Glu Ala Met Ala 
        275                 280                 285             


Thr Ala His Val Thr Glu Ile Leu Ala Asp Ile Gln Ser His Met Asp 
    290                 295                 300                 


Arg Leu Met Thr Gln Met Ala Gln Ala Lys Glu Gln Leu Asp Thr Ser 
305                 310                 315                 320 


Asn Glu Ser Ala Glu Pro Lys Ala Glu Gly Asp Glu Glu Gly Pro Ser 
                325                 330                 335     


Gly Ala Ser Glu Glu Glu Asp Thr 
            340                 


<210>  78
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ile Ile Glu Pro 
65                  70                  75                  80  


Ser Leu Arg Gln Leu Ala Gln Lys Tyr Asn Cys Asp Lys Met Ile Cys 
                85                  90                  95      


Arg Lys Cys Tyr Ala Arg Leu His Pro Arg Ala Val Asn Cys Arg Lys 
            100                 105                 110         


Lys Lys Cys Gly His Thr Asn Asn Leu Arg Pro Lys Lys Lys Val Lys 
        115                 120                 125             


<210>  79
<211>  2813
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  80
<211>  2912
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ser Ser Pro Arg Leu Ile Pro Leu Trp Lys Asp Leu Lys Leu Leu 
1               5                   10                  15      


Leu Asn Asp Thr Ile Asn Lys Ser Lys Gln Pro Ser Glu Asp Pro Lys 
            20                  25                  30          


Asn Cys Leu Ile Val Leu Ser Asp Arg Ser Gln Val Leu Phe Lys Glu 
        35                  40                  45              


Ser Arg Tyr Pro Gln Asn Met Pro Cys Val Cys Tyr Tyr Phe Ser Asp 
    50                  55                  60                  


Ala His Phe Phe Ala Ser Leu Ser Trp Val Thr Ser Asn Thr Lys Glu 
65                  70                  75                  80  


Ile Gln Ala Val Ala Trp Met Lys Ser Lys Thr Glu Asp Met Val Glu 
                85                  90                  95      


Lys Arg Thr Phe Ser Met Thr Glu Arg Leu Pro Pro Ile Gln Ser Met 
            100                 105                 110         


Val His Ala Gly Ser Phe His Ile Leu Val Val Tyr Cys Gly Asp Leu 
        115                 120                 125             


Ile Leu Arg Leu Phe Gly Asp His Phe Arg Ala Phe Lys Pro Leu Gly 
    130                 135                 140                 


Lys Val Pro Cys Arg Phe Asn Ile Ser Cys Leu Cys Tyr Asp Pro Glu 
145                 150                 155                 160 


Met Lys Met Leu Leu Ser Gly Ile Leu Gly Ala Val Val Thr Trp Val 
                165                 170                 175     


Ile Glu Leu Gly Gly Thr Gly Leu Gln Ile Ala His Met Val Ser Met 
            180                 185                 190         


Pro Gly Asp Glu Leu Val Gln Asp Ile Val Leu Asn Gly Pro Ser Gly 
        195                 200                 205             


Ser Leu Leu Ala Leu Cys Glu Thr Val Val Arg Val Leu Met His Gln 
    210                 215                 220                 


Gly Lys Gly Gln Leu Gly Glu Val Lys Arg Phe Thr Ser Thr Ser Ser 
225                 230                 235                 240 


Gly Ser Ser Ile Thr Cys Cys Phe Thr Cys Phe Asp Gln Gly Phe Leu 
                245                 250                 255     


Tyr Ala Gly Asn Gln Ala Gly Glu Ile Gln Val Trp Ser Leu Gln Gln 
            260                 265                 270         


Gly His Pro Leu His Ser Phe Gln Ala His Gln Ser Gly Val Ile Cys 
        275                 280                 285             


Ile Arg Ser Arg Pro Glu Ala His Thr Leu Leu Thr Ala Gly Ser Asp 
    290                 295                 300                 


Ser Leu Ile Lys Glu Trp Asn Leu Thr Ser Gly Ser Leu Leu Arg Arg 
305                 310                 315                 320 


Leu Glu Leu Gly Glu Glu Leu Tyr Arg Leu Gln Phe Ile Asp Ser Ile 
                325                 330                 335     


Thr Phe Phe Cys Gln Thr Ala His Ser Phe Ser Leu His Arg Leu Pro 
            340                 345                 350         


Cys Phe Tyr Ser Leu Phe Asn Val Cys Gly Ser Ala Pro Gln Gln Leu 
        355                 360                 365             


Arg Arg Val Cys Cys Gly Asn Asn Trp Phe Arg Ile Leu Cys Thr Thr 
    370                 375                 380                 


Glu Asp Gly Leu Leu Arg Phe Val Ser Pro Val Thr Gly Asp Leu Leu 
385                 390                 395                 400 


Val Ile Thr Trp Pro Phe Ser Ile Leu Asp Gln Ala Val Asp Trp Ala 
                405                 410                 415     


Tyr Asp Pro Gly Lys Glu Glu Leu Phe Val Ala Thr Gly Ser Ser Glu 
            420                 425                 430         


Val Leu Val Phe Asp Thr Thr Arg Cys Pro Cys Pro Ala Lys Tyr Leu 
        435                 440                 445             


Leu Gly Thr Ser Pro Asn Ser Gln Asp Phe Val Gln Cys Leu Ala Tyr 
    450                 455                 460                 


Gly His Phe Asn Leu Gly Arg Gly Leu Glu Gly Leu Ile Phe Ser Gly 
465                 470                 475                 480 


His Gln Ser Gly Val Ile Arg Val Leu Ser Gln His Ser Cys Ala Arg 
                485                 490                 495     


Leu Glu Lys Phe Met His Phe Gly Ala Val Leu Ala Leu Ser Thr Leu 
            500                 505                 510         


Ser Gly Gly Ile Phe Gly Gly Gln Gly Asn Ser Leu Leu Cys Ser Tyr 
        515                 520                 525             


Gly Met Asp Asp Tyr Val His Leu Ser Glu Ala Val Leu Asp Gly Val 
    530                 535                 540                 


Lys Val Gln Leu Arg Pro Leu Ala Ser Ile Leu Ser Ser Cys His Leu 
545                 550                 555                 560 


Thr His Leu Ile Leu Leu Pro Lys Ser Val Gly Ala Ile Thr Glu Thr 
                565                 570                 575     


Asn Cys Leu Arg Leu Trp Lys Phe His Asp Phe Leu Ser Ser Gly Ser 
            580                 585                 590         


Gln Asn Gly Leu Lys Phe Ile Glu Thr Leu Pro Leu His Leu Cys Ala 
        595                 600                 605             


Ile Thr Ser Phe Asp Val Cys Leu Ser Leu Ser Leu Phe Val Thr Gly 
    610                 615                 620                 


Ser Ala Asp Gly Ser Val Arg Ile Trp Asp Phe His Gly Arg Leu Ile 
625                 630                 635                 640 


Gly Ile Leu Asp Ser Ser Leu His Phe Gly Pro Val Cys Phe Ala Asn 
                645                 650                 655     


Asp Arg Gly Asp Leu Leu Val Thr Phe Asn Gln Ser Leu Tyr Leu Val 
            660                 665                 670         


Ser Cys Leu Lys Leu Leu Pro Pro Ala Leu Leu Thr Arg Leu Ser Phe 
        675                 680                 685             


Met Ser Ile Ser Asp Glu Val Leu Glu Val Pro Lys Pro Phe Ile Pro 
    690                 695                 700                 


Ser Phe Phe Phe Ser Phe Glu Thr Met Phe Val Pro Lys Tyr Ile Tyr 
705                 710                 715                 720 


Pro Gly Gln Ala Gln Gln Lys Leu Val Gly Leu Glu Lys Leu Val Asn 
                725                 730                 735     


Asn Arg Ala Ile Ala Phe Asp His Ser Val Pro His Val Ile Glu Glu 
            740                 745                 750         


Asp Glu Glu Gly Ser Pro Val Leu Leu Arg Ser Ser Met His Tyr Ser 
        755                 760                 765             


Leu Gln Asp Met Glu Asp Trp Met Gln Val Ser Lys Arg Tyr Gln Cys 
    770                 775                 780                 


His Tyr Val Leu Pro Pro Gln Leu Gln Leu Thr Ser Trp Asp Gly Leu 
785                 790                 795                 800 


Asn Pro Tyr Gln Ile Leu Arg Tyr Tyr Phe Gly His Gly Arg Glu Trp 
                805                 810                 815     


Leu Phe Ala Pro Asp Cys Tyr Ile Pro Asn Ser Val Ile Arg Ala Arg 
            820                 825                 830         


Leu Trp Pro Glu Gly Thr Pro Ile Tyr Leu Gln Cys Asn Leu His Ala 
        835                 840                 845             


Pro Gln Arg Glu Leu Glu Trp Asp Arg Ser Gln Glu Phe Phe Phe Trp 
    850                 855                 860                 


His Ser Arg Val Arg Ala Ile Ser Asn Thr Glu Tyr Pro Lys Asn Lys 
865                 870                 875                 880 


Glu Glu Asp Glu His Phe Leu Glu Met Arg Leu Ser Lys Asp Val Thr 
                885                 890                 895     


Tyr Ser Val Leu Thr Asp Gly Ala Asn Arg Ser Trp Leu Gly Arg Lys 
            900                 905                 910         


Met Ser Glu Ile Thr Ile Asn Ser Met Ile Glu Thr Met Leu Asn Ile 
        915                 920                 925             


Met Val His Ala Ser Leu Leu Lys Tyr Gln Cys Cys Val Gly Ala Leu 
    930                 935                 940                 


Gly Gln Ile Phe Ala Ser Tyr Gln Val Ser Pro Ala Leu Arg Ser Glu 
945                 950                 955                 960 


Thr Ala Arg Arg Leu Leu Asn Asp Thr Thr Asn Ser Asn Pro Leu Ile 
                965                 970                 975     


Arg Glu Leu Ala Trp Glu Gly Leu Lys Arg Leu Gly Met Ile Thr His 
            980                 985                 990         


Leu Phe Ala Met Pro Leu Ala Gln  Gly Leu Met Asp Lys  Asp Glu Arg 
        995                 1000                 1005             


Val Arg  Ile Lys Thr Leu Ser  Leu Met Ala Glu Ile  Gly Ile His 
    1010                 1015                 1020             


Ser Arg  Thr Ser Leu Leu Gln  Leu Thr Gln Lys Gln  Glu Thr Phe 
    1025                 1030                 1035             


Arg Glu  Met Gln Gln Gln Met  Ile Gly Glu Glu Pro  Leu Asp His 
    1040                 1045                 1050             


Leu Leu  Gly Met Arg Ala Thr  Asp Leu Gln Ile Leu  Ser Thr Gln 
    1055                 1060                 1065             


Val Glu  Gln Arg Leu Asn Glu  Asn Leu Thr Leu Ser  His Arg Asp 
    1070                 1075                 1080             


Glu Lys  Pro Ala Phe Ser Leu  Asp Val Ser Met Pro  Ser Glu Leu 
    1085                 1090                 1095             


Lys Ser  Ser Leu Lys Pro Pro  Thr Val Ser Glu Glu  Ser Glu Val 
    1100                 1105                 1110             


Ala Ile  Lys Pro Ser Lys Gly  Gln Arg Arg Gly Gln  Ala Gly Val 
    1115                 1120                 1125             


Lys Lys  His Ser Gln Lys Trp  Leu Arg Gly Leu Lys  Lys Thr Lys 
    1130                 1135                 1140             


Glu Arg  Asp Ser Lys Gln Met  Ser Thr Glu Pro Gly  Leu Leu Glu 
    1145                 1150                 1155             


Asp Glu  Ser Gly Thr Glu Ala  Ala Pro Ile Glu Met  Glu Glu Ala 
    1160                 1165                 1170             


Ser Val  Tyr Ser Gln Trp Ser  Ser Ser Thr Ser Val  Ile Lys Leu 
    1175                 1180                 1185             


Ser Lys  Asp Val Asp Ser Gln  Glu Lys Asp Ile Ser  Lys Asp His 
    1190                 1195                 1200             


Ile Ala  Leu Thr Leu Lys Arg  Leu Gln Lys Ile Arg  Asp Lys Arg 
    1205                 1210                 1215             


Asp Lys  Lys Ala Thr Ala Gln  Lys Leu Lys Lys Lys  His Lys Lys 
    1220                 1225                 1230             


Lys Gly  Lys Glu Ala Lys Val  Ile Asn Glu Glu Thr  Thr Pro Pro 
    1235                 1240                 1245             


Val Met  Glu Gln Pro Val Thr  Lys Lys Val Lys Ile  Gln Gly Arg 
    1250                 1255                 1260             


Gly Ala  Ser Gly Ile Ser Gly  Arg Arg Ser Thr Ala  Gly Asp Gly 
    1265                 1270                 1275             


Ser Ser  Trp Arg Asp Asp Leu  Cys Arg Leu Met Ala  Leu Arg Ile 
    1280                 1285                 1290             


Ser Gly  Ser Gln Thr Lys Met  Ser Glu Asn Leu Asn  Ala Glu Leu 
    1295                 1300                 1305             


Val Thr  Phe Ala Gln Glu Met  Leu Val Asp Arg His  Pro Ser Trp 
    1310                 1315                 1320             


Glu Leu  Phe Gln Glu Ile Cys  Pro Leu Leu Lys Lys  Glu Ser Lys 
    1325                 1330                 1335             


Val Leu  Leu Glu Asp Leu Asp  Trp Asp Val Val Pro  Pro Glu Lys 
    1340                 1345                 1350             


Lys Pro  Ile Phe Ile Gln Glu  Gly Ala Ile Arg Glu  Asp Met Ile 
    1355                 1360                 1365             


Gln Gly  Val Thr Gln Glu Val  Ile Arg His Lys Glu  Val Met Pro 
    1370                 1375                 1380             


Arg Glu  Glu Glu Gln Ala Gln  Lys Lys Ala Arg Asp  Met Leu Gly 
    1385                 1390                 1395             


Leu Glu  Glu Thr Gln Val Ile  Leu Lys Lys Gly Lys  Lys Val Ile 
    1400                 1405                 1410             


Phe Leu  Glu Pro Gly Asn Val  Thr Met Gly Lys Glu  Ile Ser Lys 
    1415                 1420                 1425             


Lys Glu  Glu Lys Lys Thr Phe  Gln Lys Ser Pro Lys  Gln Gly Arg 
    1430                 1435                 1440             


Lys Ala  Val Gln Lys Glu Arg  Lys Val Gly Lys Ile  Lys Arg Glu 
    1445                 1450                 1455             


Met Thr  Lys Glu Glu Arg Asp  Met Ser Glu Glu Val  Glu Glu Met 
    1460                 1465                 1470             


Ala Thr  Leu Glu Glu Lys Val  Val Lys Gln Glu Gly  Lys Leu Val 
    1475                 1480                 1485             


Met Ile  Glu Arg Thr Pro Ser  Trp Gln Asp Trp Lys  Lys Ala Trp 
    1490                 1495                 1500             


Asp Glu  Trp Lys Gln Val His  Gly Glu Thr Arg Lys  Ser Trp Lys 
    1505                 1510                 1515             


Ala Trp  Lys Glu Glu Trp Glu  Lys Arg Leu Leu Gln  Glu Glu Glu 
    1520                 1525                 1530             


Lys Leu  His Gln Ala Gly Glu  Lys Leu Ser Pro Glu  Glu Glu Met 
    1535                 1540                 1545             


Leu Gln  Glu Asp Lys Lys Leu  Lys Trp Glu Glu Trp  Lys Gln Val 
    1550                 1555                 1560             


Trp Glu  Asn Met Leu Ser Ser  Lys Ser Lys Glu Gln  Gln Tyr Lys 
    1565                 1570                 1575             


Asp Glu  Glu Glu Val Thr Leu  Glu Glu Glu Val Ser  Arg Glu Gly 
    1580                 1585                 1590             


Glu Glu  Lys Glu Gln Gln Val  Thr Glu Glu Gln Arg  His Ile Gln 
    1595                 1600                 1605             


Glu Glu  His Lys Trp Ala Arg  Ile His Arg Lys Arg  Ala Arg Ala 
    1610                 1615                 1620             


Glu Lys  Lys Arg Ala Gln Glu  Glu Arg Lys Leu Ala  Gln Glu Glu 
    1625                 1630                 1635             


Glu Lys  Leu Ala Gln Glu Glu  Arg Gln Leu Ala Gln  Glu Glu Arg 
    1640                 1645                 1650             


Lys Leu  Ala Gln Ala Tyr Val  Lys Ile Thr Gln Asp  Asp Arg Glu 
    1655                 1660                 1665             


Met Ala  Gln Ala Glu Gly Lys  Phe Ala Gln Lys Glu  Glu Thr Leu 
    1670                 1675                 1680             


Ala Gln  Arg Gly Glu Lys Leu  Ser Gln Glu Ala Glu  Lys Leu Ala 
    1685                 1690                 1695             


Gln Lys  Arg Lys Lys Leu Ala  Lys Lys Trp Glu Lys  Val Ala Arg 
    1700                 1705                 1710             


Glu Glu  Glu Lys Leu Ala Lys  Lys Gly Gly Lys Leu  Ala Glu Val 
    1715                 1720                 1725             


Lys Asn  Ile Leu Ala Gln Lys  Val Glu Glu Leu Pro  Gln Arg Glu 
    1730                 1735                 1740             


Gln Asn  Leu Asp Trp Gln Glu  Lys Glu Leu Ala Gln  Glu Leu Glu 
    1745                 1750                 1755             


Glu Leu  Glu Trp Asp Met Glu  Glu Leu Ser Trp Lys  Glu Glu Glu 
    1760                 1765                 1770             


Leu Asn  Gln Glu Glu Gly Lys  Leu Val Glu Glu Lys  Lys Lys Leu 
    1775                 1780                 1785             


Ala Glu  Glu Glu Glu Ala Leu  Ala Trp Gln Arg Glu  Lys Leu Ser 
    1790                 1795                 1800             


Glu Glu  Glu Thr Lys Leu Ala  Gln Glu Glu Glu Leu  Leu Ile Gln 
    1805                 1810                 1815             


Glu Lys  Glu Lys Leu Ala Gln  His Lys Glu Lys Met  Pro Glu Glu 
    1820                 1825                 1830             


Glu Glu  Arg Leu Gly Arg Lys  Arg Glu Gln Leu Ile  Glu Lys Lys 
    1835                 1840                 1845             


Met Lys  Leu Ala Gln Lys Arg  Glu Arg Trp Ile Asn  Ser Met Glu 
    1850                 1855                 1860             


Glu Leu  Thr Lys Asn Lys Met  Ile Leu Tyr Gln Lys  Lys Asn Leu 
    1865                 1870                 1875             


Ala Gln  Glu Lys Lys Asn Leu  Ala Gln Glu Lys Glu  Lys Leu Ala 
    1880                 1885                 1890             


Gln Arg  Lys Glu Asn Leu Leu  Tyr Asn Lys Glu Arg  Leu Thr His 
    1895                 1900                 1905             


Ser Lys  Lys Gln Leu Val Gln  Val Lys Asn Lys Leu  Gly Met Phe 
    1910                 1915                 1920             


Asn Lys  Ile Leu Ala Gln Val  Glu Glu Lys Leu Thr  Gln Glu Lys 
    1925                 1930                 1935             


Glu Thr  Val Ile Lys Lys Lys  Glu Lys Leu Ala Glu  Thr Glu Lys 
    1940                 1945                 1950             


Lys Leu  Val Gln Val Glu Asp  Ser Leu Ala Lys Lys  Gln Glu Lys 
    1955                 1960                 1965             


Leu Ala  Gln Glu Lys Met Lys  Leu Ala Leu Glu Lys  Ala Met Val 
    1970                 1975                 1980             


Gln Gly  Lys Lys Arg Leu Arg  Gly Glu Leu Asp Ile  Ala Lys Glu 
    1985                 1990                 1995             


Glu Lys  Ala Leu Asn Leu Glu  Met Lys Arg Leu Ala  Glu Glu Lys 
    2000                 2005                 2010             


Met Arg  Leu Val Glu Gly Lys  Glu Thr Leu Ser Lys  Gly Glu Thr 
    2015                 2020                 2025             


Pro Glu  Thr Ser Arg Gln Arg  Lys Met Thr Gln Val  Glu Gln Glu 
    2030                 2035                 2040             


Leu Phe  Glu Arg Lys Leu Ser  Leu Glu Glu Lys Ile  Leu Leu His 
    2045                 2050                 2055             


Glu Asp  Arg Ile Leu Ala Met  Glu Glu Ser Glu Ile  Ala Lys Gly 
    2060                 2065                 2070             


Lys Leu  Glu Phe Thr Arg Gly  Gln Arg Ile Phe Val  Gln Gly Gln 
    2075                 2080                 2085             


Arg Lys  Leu Ala Lys Ala Ser  Arg Lys Leu Ile Lys  Lys Arg Glu 
    2090                 2095                 2100             


Ser Leu  Ser Lys Glu Pro Ala  Lys Leu Asn Lys Ile  Leu Lys Ala 
    2105                 2110                 2115             


Leu Gln  Lys Leu Thr Arg Asp  Glu Arg Lys Leu Thr  Gln Glu Glu 
    2120                 2125                 2130             


Ile Lys  Met Thr Lys Met Lys  Arg Ala Leu Phe Val  Lys Glu Arg 
    2135                 2140                 2145             


Arg Leu  Ser Ile Glu Gln Ser  Lys Leu Asp Ile Lys  Glu Trp Asp 
    2150                 2155                 2160             


Phe Ser  Glu Lys Arg Ser Glu  Leu Thr Lys Asp Glu  Lys Lys Leu 
    2165                 2170                 2175             


Ala Arg  Lys Gln Arg Lys Leu  Ala Asn Lys Met Arg  Arg Met Ile 
    2180                 2185                 2190             


Asn Lys  Glu Glu Lys Met Thr  Glu Glu Glu Ser Lys  Leu Ala Arg 
    2195                 2200                 2205             


Lys His  Ser Glu Val Ile Leu  Asp Asp Glu Glu Glu  Gly Gly Ile 
    2210                 2215                 2220             


Glu Glu  Glu Glu Val Ile Pro  Phe Leu Lys Arg Arg  Trp Arg Lys 
    2225                 2230                 2235             


Arg Lys  Glu Ala Lys Arg Gly  Asp Lys Pro Lys Glu  Lys Phe Ser 
    2240                 2245                 2250             


Ser Gln  Val Asp Glu Val Glu  Ser Glu Glu His Phe  Ser Glu Glu 
    2255                 2260                 2265             


Met Glu  Ser Leu Leu Asp Glu  Leu Glu Lys Gln Glu  Ser Leu Ser 
    2270                 2275                 2280             


Ser Glu  Glu Glu Glu Glu Arg  Glu Glu Glu Glu Glu  Arg Glu Glu 
    2285                 2290                 2295             


Glu Glu  Glu Arg Glu Glu Glu  Glu Glu Arg Lys Glu  Glu Glu Glu 
    2300                 2305                 2310             


Gly Glu  Glu Lys Gln Val Glu  Lys Glu Glu Glu Glu  Lys Lys Lys 
    2315                 2320                 2325             


Lys Lys  Lys Glu Lys Lys Lys  Glu Glu Val Gln Glu  Lys Glu Glu 
    2330                 2335                 2340             


Val Phe  Glu Glu Lys Glu Glu  Ile Met Ser Glu Glu  Glu Thr Glu 
    2345                 2350                 2355             


Ser Leu  Ser Asp Glu Glu Glu  Glu Glu Glu Ser Cys  Ser Leu Glu 
    2360                 2365                 2370             


Glu Glu  Val Asp Arg Glu Lys  Glu Ile Leu Lys Lys  Glu Lys Gln 
    2375                 2380                 2385             


Phe Lys  Leu Gln Glu Gln Arg  Arg Lys Ser Leu Arg  Gly Arg Glu 
    2390                 2395                 2400             


Arg Val  Leu Ser Ile Leu Arg  Gly Val Pro His Gly  Lys Gly Arg 
    2405                 2410                 2415             


Ala Ile  Arg Leu Gly Val Leu  Lys Ser Pro Leu Lys  Lys Leu Met 
    2420                 2425                 2430             


Ser Thr  Ala Leu Glu Met Lys  Glu Lys Thr Pro Val  Pro Val Pro 
    2435                 2440                 2445             


Glu Lys  Gln Ile Ser Trp Glu  Asp Lys Lys Ala Thr  Val Val Glu 
    2450                 2455                 2460             


Ile Pro  Arg Lys Phe Leu Gly  Thr Met Asp Lys Glu  Arg Glu Val 
    2465                 2470                 2475             


Met Gly  Lys Tyr Glu Pro Ile  Pro Pro His Val Leu  Gly Thr Val 
    2480                 2485                 2490             


Leu Glu  Ser Gln Ala Gln Asp  Leu Lys Thr Pro Phe  Met Ser His 
    2495                 2500                 2505             


Ile Leu  Arg Arg Thr Val Glu  Ala Glu Glu Leu Gln  His Lys Pro 
    2510                 2515                 2520             


Leu Gly  Ala Trp Trp Lys Trp  Phe Leu Gln His Pro  Pro Leu Met 
    2525                 2530                 2535             


Gly Gln  Thr Glu Val Gln Leu  Pro Leu Ser Gln Ile  Pro Ala Lys 
    2540                 2545                 2550             


Glu Gln  His Ala Asp Val Ser  Leu Ser Asp Val Glu  Trp Ile Arg 
    2555                 2560                 2565             


His Val  Leu Glu Arg Met Glu  Ala Gly Glu Gln Leu  Ser Arg Asp 
    2570                 2575                 2580             


Gly Phe  His Arg Leu Cys Gln  Leu Leu Lys Asp Leu  Ala Ser Lys 
    2585                 2590                 2595             


Gly Asn  Leu Glu Trp Leu His  Leu Ala Lys His Glu  Ala Ile Val 
    2600                 2605                 2610             


Tyr Arg  His Arg Gln Ala Leu  Glu Ser Gln Asp Thr  Arg Ile Ser 
    2615                 2620                 2625             


Ser Arg  Gln Ser Met Ser Pro  Lys Tyr Leu Lys Val  Ile Pro Pro 
    2630                 2635                 2640             


Ile Lys  Ala Lys Glu Lys Glu  Ser Trp Pro Lys Pro  Leu Ala Val 
    2645                 2650                 2655             


Pro Thr  Gln Lys Ser Pro Leu  Ala Thr Lys Arg Ile  Pro Asp Pro 
    2660                 2665                 2670             


Arg Ala  Lys Asn Trp His Leu  Leu Gly Glu Pro Tyr  Arg Ser Glu 
    2675                 2680                 2685             


Arg Ala  Gln Gln Ile Ser Ile  Ala His Lys Glu Met  Glu Met Gln 
    2690                 2695                 2700             


Tyr Phe  Tyr Pro Ala Thr Arg  Asp Ile Phe Pro Ser  Ala His Ala 
    2705                 2710                 2715             


Ser Val  Glu Lys Gln Thr Leu  Ala Leu Met Phe Gln  Lys Asp Phe 
    2720                 2725                 2730             


Trp Asp  Phe Lys Asp Lys Arg  Arg Phe Pro Lys Leu  Pro Lys Leu 
    2735                 2740                 2745             


Glu Lys  Lys Thr Gln Pro Ile  Ser Lys Lys Lys Glu  Glu Leu Pro 
    2750                 2755                 2760             


Leu Trp  Glu Thr Phe Val Ala  Leu Tyr His Val Leu  Arg Met Leu 
    2765                 2770                 2775             


Gln Gln  Arg Tyr Pro Lys Asp  Ser Thr Ala Trp Met  Glu Gln Phe 
    2780                 2785                 2790             


Tyr Gln  Leu Met Asp Leu Tyr  Gln Leu Lys Ser Pro  Arg Ile Gln 
    2795                 2800                 2805             


Lys Leu  Leu Gln Glu Leu Leu  Met Arg Glu Glu Pro  Gln Pro Gln 
    2810                 2815                 2820             


Glu Ile  Ile Tyr Glu Glu Ala  Leu Lys Ala Thr Glu  Leu Val Pro 
    2825                 2830                 2835             


Gly Glu  Arg Leu Phe Cys Cys  Leu Phe Cys Gly Ser  Ser His Thr 
    2840                 2845                 2850             


Pro Arg  Ser Pro Gln Glu Phe  Gln Gly Ala Val Pro  Leu Pro Trp 
    2855                 2860                 2865             


Gln Asn  Cys Val Arg Thr Ile  Leu Pro Val Gly Ile  Ala Arg Tyr 
    2870                 2875                 2880             


Gly Ile  Leu Glu Leu Ala Trp  Lys Ser Leu Pro Glu  Ala Asp Leu 
    2885                 2890                 2895             


His Leu  Thr Lys Ala Leu Thr  His Thr Val Ala Pro  Thr Leu 
    2900                 2905                 2910         


<210>  81
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ser His Thr Ala Ser Ser Cys Gln Glu Leu Val Glu Asn Cys Ala 
1               5                   10                  15      


Val His Val Ala Gly Met Ala Gln Glu Asp Ser Arg Arg Gly Gln Val 
            20                  25                  30          


Pro Ser Ser Phe Tyr His Gly Ala Asn Gln Glu Leu Asp Leu Ser Thr 
        35                  40                  45              


Lys Val Tyr Lys Arg Glu Ser Gly Ser Pro Tyr Ser Val Leu Val Asp 
    50                  55                  60                  


Thr Lys Met Ser Lys Pro His Leu His Glu Thr Glu Glu Gln Pro Tyr 
65                  70                  75                  80  


Phe Arg Glu Thr Arg Ala Val Ser Asp Val His Ala Val Lys Glu Asp 
                85                  90                  95      


Arg Glu Asn Ser Asp Asp Thr Glu Glu Glu Glu Glu Glu Val Ser Tyr 
            100                 105                 110         


Lys Arg Glu Gln Ile Ile Val Glu Val Asn Leu Asn Asn Gln Thr Leu 
        115                 120                 125             


Asn Val Ser Lys Gly Glu Lys Gly Val Ser Ser Gln Ser Lys Glu Thr 
    130                 135                 140                 


Pro Val Leu Lys Thr Ser Ser Glu Glu Glu Glu Glu Glu Ser Glu Glu 
145                 150                 155                 160 


Glu Ala Thr Asp Asp Ser Asn Asp Tyr Gly Glu Asn Glu Lys Gln Lys 
                165                 170                 175     


Lys Lys Glu Lys Ile Val Glu Lys Val Ser Val Thr Gln Arg Arg Thr 
            180                 185                 190         


Arg Arg Ala Ala Ser Val Ala Ala Ala Thr Thr Ser Pro Thr Pro Arg 
        195                 200                 205             


Thr Thr Arg Gly Arg Arg Lys Ser Val Glu Pro Pro Lys Arg Lys Lys 
    210                 215                 220                 


Arg Ala Thr Lys Glu Pro Lys Ala Pro Val Gln Lys Ala Lys Cys Glu 
225                 230                 235                 240 


Glu Lys Glu Thr Leu Thr Cys Glu Lys Cys Pro Arg Val Phe Asn Thr 
                245                 250                 255     


Arg Trp Tyr Leu Glu Lys His Met Asn Val Thr His Arg Arg Met Gln 
            260                 265                 270         


Ile Cys Asp Lys Cys Gly Lys Lys Phe Val Leu Glu Ser Glu Leu Ser 
        275                 280                 285             


Leu His Gln Gln Thr Asp Cys Glu Lys Asn Ile Gln Cys Val Ser Cys 
    290                 295                 300                 


Asn Lys Ser Phe Lys Lys Leu Trp Ser Leu His Glu His Ile Lys Ile 
305                 310                 315                 320 


Val His Gly Tyr Ala Glu Lys Lys Phe Ser Cys Glu Ile Cys Glu Lys 
                325                 330                 335     


Lys Phe Tyr Thr Met Ala His Val Arg Lys His Met Val Ala His Thr 
            340                 345                 350         


Lys Asp Met Pro Phe Thr Cys Glu Thr Cys Gly Lys Ser Phe Lys Arg 
        355                 360                 365             


Ser Met Ser Leu Lys Val His Ser Leu Gln His Ser Gly Glu Lys Pro 
    370                 375                 380                 


Phe Arg Cys Glu Asn Cys Asp Glu Arg Phe Gln Tyr Lys Tyr Gln Leu 
385                 390                 395                 400 


Arg Ser His Met Ser Ile His Ile Gly His Lys Gln Phe Met Cys Gln 
                405                 410                 415     


Trp Cys Gly Lys Asp Phe Asn Met Lys Gln Tyr Phe Asp Glu His Met 
            420                 425                 430         


Lys Thr His Thr Gly Glu Lys Pro Phe Ile Cys Glu Ile Cys Gly Lys 
        435                 440                 445             


Ser Phe Thr Ser Arg Pro Asn Met Lys Arg His Arg Arg Thr His Thr 
    450                 455                 460                 


Gly Glu Lys Pro Tyr Pro Cys Asp Val Cys Gly Gln Arg Phe Arg Phe 


<210>  82
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn Ser Lys Ile Tyr Cys 
1               5                   10                  15      


Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro Leu Glu Trp Phe Lys 
            20                  25                  30          


Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg Ala His Lys Ser Phe 
        35                  40                  45              


Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala Gly Asp Tyr Thr Cys 
    50                  55                  60                  


Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser Val Thr Ala Thr 
65                  70                  75                  80  


Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe Ser Leu Phe Pro Val 
                85                  90                  95      


Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu Val Glu Ile Gly Lys 
            100                 105                 110         


Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly Lys Gly Thr Gln Phe 
        115                 120                 125             


Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr Lys Ile Thr Asp Phe 
    130                 135                 140                 


Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln Asn Gln Ser Phe Ser 
145                 150                 155                 160 


Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg Ile Ala Asp Val Lys 
                165                 170                 175     


Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu Ala Leu Asn Leu His 
            180                 185                 190         


Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg Lys Asn Pro Ser Lys 
        195                 200                 205             


Glu Cys Phe 
    210     



465                 470                 475                 480 


Ser Asn Met Leu Lys Ala His Lys Glu Lys Cys Phe Arg Val Thr Ser 
                485                 490                 495     


Pro Val Asn Val Pro Pro Ala Val Gln Ile Pro Leu Thr Thr Ser Pro 
            500                 505                 510         


Ala Thr Pro Val Pro Ser Val Val Asn Thr Ala Thr Thr Pro Thr Pro 
        515                 520                 525             


Pro Ile Asn Met Asn Pro Val Ser Thr Leu Pro Pro Arg Pro Ile Pro 
    530                 535                 540                 


His Pro Phe Ser His Leu His Ile His Pro His Pro His His Pro His 
545                 550                 555                 560 


His Leu Pro Ile Pro Pro Val Pro His Leu Pro Pro Pro Pro Ala Leu 
                565                 570                 575     


Phe Lys Ser Glu Pro Leu Asn His Arg Gly Gln Ser Glu Asp Asn Phe 
            580                 585                 590         


Leu Arg His Leu Ala Glu Lys Asn Ser Ser Ala Gln His His 
        595                 600                 605     


