                         SEQUENCE LISTING

<110>  MOMA Therapeutics, Inc.
       Garner, Andrew
       Chicas, Agustin
       Orlando, David
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

<130>  MOMA-001/01WO 340678-2002

<150>  US 63/043,430
<151>  2020-06-24

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys 
1               5                   10                  15      


Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu 
            20                  25                  30          


Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu 
        35                  40                  45              


Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu 
    50                  55                  60                  


Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly 
65                  70                  75                  80  


Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala 
                85                  90                  95      


Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp 
            100                 105                 110         


Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys Gln Leu 
        115                 120                 125             


Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu Asp Glu 
    130                 135                 140                 


Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Glu Thr Pro 
145                 150                 155                 160 


Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly Glu 
                165                 170                 175     


Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser Lys 
            180                 185                 190         


Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys 
        195                 200                 205             


Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala 
    210                 215                 220                 


Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys 
225                 230                 235                 240 


Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala 
                245                 250                 255     


Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn 
            260                 265                 270         


Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro 
        275                 280                 285             


Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala 
    290                 295                 300                 


Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val 
305                 310                 315                 320 


Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn 
                325                 330                 335     


His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly 
            340                 345                 350         


Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser 
        355                 360                 365             


Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu 
    370                 375                 380                 


Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu Thr 
385                 390                 395                 400 


Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr Gly 
                405                 410                 415     


Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe Val 
            420                 425                 430         


Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser Gly 
        435                 440                 445             


Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu Ser 
    450                 455                 460                 


Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala Met 
465                 470                 475                 480 


Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp Leu 
                485                 490                 495     


Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro Asp 
            500                 505                 510         


Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg Leu 
        515                 520                 525             


Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met Leu 
    530                 535                 540                 


Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu Glu 
545                 550                 555                 560 


Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln Ile 
                565                 570                 575     


His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln Glu 
            580                 585                 590         


Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys Ile 
        595                 600                 605             


Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val Ala 
    610                 615                 620                 


Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr Thr 
625                 630                 635                 640 


Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys 
                645                 650                 655     


Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val Arg 
            660                 665                 670         


Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val Glu 
        675                 680                 685             


Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp Ile 
    690                 695                 700                 


Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys Glu 
705                 710                 715                 720 


Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile Ala 
                725                 730                 735     


Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp Gly 
            740                 745                 750         


Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly Arg 
        755                 760                 765             


Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr Asp 
    770                 775                 780                 


Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly Phe 
785                 790                 795                 800 


Ser Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala Leu Val 
                805                 810                 815     


Leu Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile Pro 
            820                 825                 830         


Asp His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala Asp 
        835                 840                 845             


Leu Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp Ser 
    850                 855                 860                 


Asp Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg Glu 
865                 870                 875                 880 


Asp Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys Leu 
                885                 890                 895     


Tyr Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser Gly 
            900                 905                 910         


Ser Asp Pro Glu Asp Thr Tyr 
        915                 


<210>  2
<211>  3410
<212>  DNA
<213>  Homo sapiens

<400>  2
ctcgcggggg cgcttccacc gattcctcct ctttccctgc cagtcactcc tcagaccctc       60

agccacaccc gctcatccag ggcgagggaa agcgcgggca ttttcccagt gtgctctgcg      120

ggagggctcg ccccacttca ccccttttcc cgccctcctc ccattcggga gactacgact      180

cccagtgtcc tccgcgcgac ggcggcggtg cggacggtgc ccaggtcccg cccctaggct      240

ctgccccgcc cccgcccgca gacgtctgcg cgcgaatgcc gtggcgcgaa cttgggactg      300

cagaggcgcg cctggcggat ctgagtgtgt tgcccgggca gcggcgcgcg ggaccaacgc      360

aaggagcagc tgacagacga agaaaagtgc tggacaggaa gggagaattc tgacgccaac      420

atgcagcgaa gtatcatgtc atttttccac cccaagaaag agggtaaagc aaagaagcct      480

gagaaggagg catccaatag cagcagagag acggagcccc ctccaaaggc ggcactgaag      540

gagtggaatg gagtggtgtc cgagagtgac tctccggtga agaggccagg gaggaaggcg      600

gcccgggtcc tgggcagcga aggggaagag gaggatgaag cccttagccc tgctaaaggc      660

cagaagcctg ccctggactg ctcacaggtc tccccgcccc gtcctgccac atctcctgag      720

aacaatgctt ccctctctga cacctctccc atggacagtt ccccatcagg gattccgaag      780

cgtcgcacag ctcggaagca gctcccgaaa cggaccattc aggaagtcct ggaagagcag      840

agtgaggacg aggacagaga agccaagagg aagaaggagg aggaagaaga ggagaccccg      900

aaagaaagcc tcacagaggc tgaagtggcc acagagaagg aaggagaaga cggggaccag      960

cccaccacgc ctcccaagcc cctaaagacc tccaaagcag agaccccgac ggaaagcgtt     1020

tcagagcctg aggtggccac gaagcaggaa ctgcaggagg aggaagagca gaccaagcct     1080

ccccgcagag ctcccaagac gctcagcagc ttcttcaccc cccggaagcc agcagtcaaa     1140

aaagaagtga aggaagagga gccaggggct ccaggaaagg agggagctgc tgagggaccc     1200

ctggatccat ctggttacaa tcctgccaag aacaactatc atcccgtgga agatgcctgc     1260

tggaaaccgg gccagaaggt tccttacctg gctgtggccc ggacgtttga gaagatcgag     1320

gaggtgtctg ctcggctccg gatggtggag acgctgagca acttgctgcg ctccgtggtg     1380

gccctgtcgc ctccagacct cctccctgtc ctctacctca gcctcaacca ccttgggcca     1440

ccccagcagg gcctggagct tggcgtgggt gatggtgtcc ttctcaaggc agtggcccag     1500

gccacaggtc ggcagctgga gtccgtccgg gctgaggcag ccgagaaagg cgacgtgggg     1560

ctggtggccg agaacagccg cagcacccag aggctcatgc tgccaccacc tccgctcact     1620

gcctccgggg tcttcagcaa gttccgcgac atcgccaggc tcactggcag tgcttccaca     1680

gccaagaaga tagacatcat caaaggcctc tttgtggcct gccgccactc agaagcccgg     1740

ttcatcgcta ggtccctgag cggacggctg cgccttgggc tggcagagca gtcggtgctg     1800

gctgccctct cccaggcagt gagcctcacg cccccgggcc aagaattccc accagccatg     1860

gtggatgctg ggaagggcaa gacagcagag gccagaaaga cgtggctgga ggagcaaggc     1920

atgatcctga agcagacgtt ctgcgaggtt cccgacctgg accgaattat ccccgtgctg     1980

ctggagcacg gcctggaacg tctcccggag cactgcaagc tgagcccagg gattcccctg     2040

aaaccaatgt tggcccatcc cacccggggc atcagcgagg tcctgaaacg ctttgaggag     2100

gcagctttca cctgcgaata caaatatgac gggcagaggg cacagatcca cgccctggaa     2160

ggcggggagg tgaagatctt cagcaggaat caggaagaca acactgggaa gtacccggac     2220

atcatcagcc gcatccccaa gattaaactc ccatcggtca catccttcat cctggacacc     2280

gaagccgtgg cttgggaccg ggaaaagaag cagatccagc cattccaagt gctcaccacc     2340

cgcaaacgca aggaggtgga tgcgtctgag atccaggtgc aggtgtgttt gtacgccttc     2400

gacctcatct acctcaatgg agagtccctg gtacgtgagc ccctttcccg gcgccggcag     2460

ctgctccggg agaactttgt ggagacagag ggcgagtttg tcttcgccac ctccctggac     2520

accaaggaca tcgagcagat cgccgagttc ctggagcagt cagtgaaaga ctcctgcgag     2580

gggctgatgg tgaagaccct ggatgttgat gccacctacg agatcgccaa gagatcgcac     2640

aactggctca agctgaagaa ggactacctt gatggcgtgg gtgacaccct ggacctggtg     2700

gtgatcggcg cctacctggg ccgggggaag cgggccggcc ggtacggggg cttcctgctg     2760

gcctcctacg acgaggacag tgaggagctg caggccatat gcaagcttgg aactggcttc     2820

agtgatgagg agctggagga gcatcaccag agcctcaagg cgctggtgct gcccagccca     2880

cgcccttacg tgcggataga tggcgctgtg attcccgacc actggctgga ccccagcgct     2940

gtgtgggagg tgaagtgcgc tgacctctcc ctctctccca tctaccctgc tgcgcggggc     3000

ctggtggata gtgacaaggg catctccctt cgcttccctc ggtttattcg agtccgtgaa     3060

gacaagcagc cggagcaggc caccaccagt gctcaggtgg cctgtttgta ccggaagcaa     3120

agtcagattc agaaccaaca aggcgaggac tcaggctctg accctgaaga tacctactaa     3180

gccctcgccc tcctagggcc tgggtacagg gcatgagttg gacggacccc agggttatta     3240

ttgcctttgc tttttagcaa atctgctgtg gcaggctgtg gattttgaga gtcaggggag     3300

gggtgtgtgt gtgagggggt ggcttactcc ggagtctggg attcatcccg tcatttcttt     3360

caataaataa ttattggata gctaaaaaaa aaaaaaaaaa aaaaaaaaaa                3410


<210>  3
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys 
1               5                   10                  15      


Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu 
            20                  25                  30          


Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu 
        35                  40                  45              


Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu 
    50                  55                  60                  


Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly 
65                  70                  75                  80  


Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala 
                85                  90                  95      


Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp 
            100                 105                 110         


Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys Gln Leu 
        115                 120                 125             


Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu Asp Glu 
    130                 135                 140                 


Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Glu Thr Pro 
145                 150                 155                 160 


Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly Glu 
                165                 170                 175     


Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser Lys 
            180                 185                 190         


Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys 
        195                 200                 205             


Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala 
    210                 215                 220                 


Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys 
225                 230                 235                 240 


Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala 
                245                 250                 255     


Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn 
            260                 265                 270         


Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro 
        275                 280                 285             


Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala 
    290                 295                 300                 


Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val 
305                 310                 315                 320 


Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn 
                325                 330                 335     


His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly 
            340                 345                 350         


Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser 
        355                 360                 365             


Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu 
    370                 375                 380                 


Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu Thr 
385                 390                 395                 400 


Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr Gly 
                405                 410                 415     


Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe Val 
            420                 425                 430         


Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser Gly 
        435                 440                 445             


Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu Ser 
    450                 455                 460                 


Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala Met 
465                 470                 475                 480 


Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp Leu 
                485                 490                 495     


Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro Asp 
            500                 505                 510         


Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg Leu 
        515                 520                 525             


Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met Leu 
    530                 535                 540                 


Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu Glu 
545                 550                 555                 560 


Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln Ile 
                565                 570                 575     


His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln Glu 
            580                 585                 590         


Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys Ile 
        595                 600                 605             


Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val Ala 
    610                 615                 620                 


Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr Thr 
625                 630                 635                 640 


Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys 
                645                 650                 655     


Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val Arg 
            660                 665                 670         


Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val Glu 
        675                 680                 685             


Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp Ile 
    690                 695                 700                 


Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys Glu 
705                 710                 715                 720 


Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile Ala 
                725                 730                 735     


Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp Gly 
            740                 745                 750         


Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly Arg 
        755                 760                 765             


Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr Asp 
    770                 775                 780                 


Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Val Leu Gly Asn Trp 
785                 790                 795                 800 


Gly 
    


<210>  4
<211>  3957
<212>  DNA
<213>  Homo sapiens

<400>  4
gaccaacgca aggagcagct gacagacgaa gaaaagtgct ggacaggaag ggagaattct       60

gatgccaaca tgcagcgaag tatcatgtca tttttccacc ccaagaaaga gggtaaagca      120

aagaagcctg agaaggaggc atccaatagc agcagagaga cggagccccc tccaaaggcg      180

gcactgaagg agtggaatgg agtggtgtcc gagagtgact ctccggtgaa gaggccaggg      240

aggaaggcgg cccgggtcct gggcagcgaa ggggaagagg aggatgaagc ccttagccct      300

gctaaaggcc agaagcctgc cctggactgc tcacaggtct ccccgccccg tcctgccaca      360

tctcctgaga acaatgcttc cctctctgac acctctccca tggacagttc cccatcaggg      420

attccgaagc gtcgcacagc tcggaagcag ctcccgaaac ggaccattca ggaagtcctg      480

gaagagcaga gtgaggacga ggacagagaa gccaagagga agaaggagga ggaagaagag      540

gagaccccga aagaaagcct cacagaggct gaagtggcaa cagagaagga aggagaagac      600

ggggaccagc ccaccacgcc tcccaagccc ctaaagacct ccaaagcaga gaccccgacg      660

gaaagcgttt cagagcctga ggtggccacg aagcaggaac tgcaggagga ggaagagcag      720

accaagcctc cccgcagagc tcccaagacg ctcagcagct tcttcacccc ccggaagcca      780

gcagtcaaaa aagaagtgaa ggaagaggag ccaggggctc caggaaagga gggagctgct      840

gagggacccc tggatccatc tggttacaat cctgccaaga acaactatca tcccgtggaa      900

gatgcctgct ggaaaccggg ccagaaggtt ccttacctgg ctgtggcccg gacgtttgag      960

aagatcgagg aggtgtctgc tcggctccgg atggtggaga cgctgagcaa cttgctgcgc     1020

tccgtggtgg ccctgtcgcc tccagacctc ctccctgtcc tctacctcag cctcaaccac     1080

cttgggccac cccagcaggg cctggagctt ggcgtgggtg atggtgtcct tctcaaggca     1140

gtggcccagg ccacaggtcg gcagctggag tccgtccggg ctgaggcagc cgagaaaggc     1200

gacgtggggc tggtggccga gaacagccgc agcacccaga ggctcatgct gccaccacct     1260

ccgctcactg cctccggggt cttcagcaag ttccgcgaca tcgccaggct cactggcagt     1320

gcttccacag ccaagaagat agacatcatc aaaggcctct ttgtggcctg ccgccactca     1380

gaagcccggt tcatcgctag gtccctgagc ggacggctgc gccttgggct ggcagagcag     1440

tcggtgctgg ctgccctctc ccaggcagtg agcctcacgc ccccgggcca agaattccca     1500

ccagccatgg tggatgctgg gaagggcaag acagcagagg ccagaaagac gtggctggag     1560

gagcaaggca tgatcctgaa gcagacgttc tgcgaggttc ccgacctgga ccgaattatc     1620

cccgtgctgc tggagcacgg cctggaacgt ctcccggagc actgcaagct gagcccaggg     1680

attcccctga aaccaatgtt ggcccatccc acccggggca tcagcgaggt cctgaaacgc     1740

tttgaggagg cagctttcac ctgcgaatac aaatatgacg ggcagagggc acagatccac     1800

gccctggaag gcggggaggt gaagatcttc agcaggaatc aggaagacaa cactgggaag     1860

tacccggaca tcatcagccg catccccaag attaaactcc catcggtcac atccttcatc     1920

ctggacaccg aagccgtggc ttgggaccgg gaaaagaagc agatccagcc attccaagtg     1980

ctcaccaccc gcaaacgcaa ggaggtggat gcgtctgaga tccaggtgca ggtgtgtttg     2040

tacgccttcg acctcatcta cctcaatgga gagtccctgg tacgtgagcc cctttcccgg     2100

cgccggcagc tgctccggga gaactttgtg gagacagagg gcgagtttgt cttcgccacc     2160

tccctggaca ccaaggacat cgagcagatc gccgagttcc tggagcagtc agtgaaagac     2220

tcctgcgagg ggctgatggt gaagaccctg gatgttgatg ccacctacga gatcgccaag     2280

agatcgcaca actggctcaa gctgaagaag gactaccttg atggcgtggg tgacaccctg     2340

gacctggtgg tgatcggcgc ctacctgggc cgggggaagc gggccggccg gtacgggggc     2400

ttcctgctgg cctcctacga cgaggacagt gaggagctgc aggccatatg caaggtcctg     2460

gggaactggg gctgatggca gaagcaggag ggaaggagat tagactcccg ggggtatttc     2520

ctattgcaca acccagaccg aggggtgctc acatccccct gtgaaggatc cgttctcccc     2580

agtttttatt tactttttct ggttctatga gcaactcttg cttcatatag aaaaacaggc     2640

tgggatagaa agatgtcagg aatgtgtgtc agtgagagat tgagattagc tacaaatagt     2700

ggtggctcac ataagaaaag aatttttttg ttatgaaatg agaagtgtgg agggggcagt     2760

ctgatgccat tagggattca ggttcctcct ctccccacat ttttttttgt ccccacattt     2820

tttttttctg ccatgtgcct ctggcctcat catcacaatg tggctgcagg agttccagcc     2880

ctcatggcca tgcctgctcc acgcaccagg gaagagcaaa gggggttgga ccctgagtca     2940

gcctcagcca gtgaacacct tctgctcaag ttctgttgct catcactttg ctccatggct     3000

cacccctagc tgcaaggaat tctgggaaat gtaaagtgat ttactttttt tcaagttaaa     3060

gtttttctta aagctgtgca cattttggac tagattttct tacgtatttc ctatattccc     3120

ctctccaaca aatttgggtc ttttgccaca gaaacagaac aaaatatcac ctagaatcgt     3180

accacccaga gacacgcagt agtgacattt gagggaatgt tttatttaca tttttgcaaa     3240

gttgtgatcc ttctctatga gtaattttct tttctgcctt tttaccctgg aagtactttg     3300

ttttcagtgt tgtatatgcc cttaagcaat atggcaacag gacctgaatg cccgcacaag     3360

agttttcaag tgctgtgccc catagcacat agtgctgtgt cctgaaccag ctccccgtgg     3420

ctgtgtgggg aagttgttgc cggctttgtt ctgatggctt ggaactggct tcagtgacga     3480

ggagctggag gagcatcacc agagcctcaa ggcgctggtg ctgcccagcc cacgccctta     3540

cgtgcggata gatggcgctg tgattcccga ccactggctg gaccccagcg ctgtgtggga     3600

ggtgaagtgc gctgacctct ccctctctcc catctaccct gctgcgcggg gcctggtgga     3660

tagtgacaag ggcatctccc ttcgcttccc tcggtttatt cgagtccgtg aagacaagca     3720

gccggagcag gccaccacca gtgctcaggt ggcctgtttg taccggaagc aaagtcagat     3780

tcagaaccaa caaggcgagg actcaggctc tgaccctgaa gatacctact aagccctcgc     3840

cctcctaggg cctgggtaca gggcatgagt tggacggacc ccagggttat tattgccttt     3900

gctttttagc aaatctgctg tggcaggctg tggattttga gagtcagggg aggggtg        3957


<210>  5
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gln Arg Ser Ile Met Ala Ala Leu Lys Glu Trp Asn Gly Val Val 
1               5                   10                  15      


Ser Glu Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg 
            20                  25                  30          


Val Leu Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala 
        35                  40                  45              


Lys Gly Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg 
    50                  55                  60                  


Pro Ala Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro 
65                  70                  75                  80  


Met Asp Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys 
                85                  90                  95      


Gln Leu Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu 
            100                 105                 110         


Asp Glu Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Thr 
        115                 120                 125             


Pro Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly 
    130                 135                 140                 


Glu Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser 
145                 150                 155                 160 


Lys Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr 
                165                 170                 175     


Lys Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg 
            180                 185                 190         


Ala Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val 
        195                 200                 205             


Lys Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly 
    210                 215                 220                 


Ala Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn 
225                 230                 235                 240 


Asn Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val 
                245                 250                 255     


Pro Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser 
            260                 265                 270         


Ala Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val 
        275                 280                 285             


Val Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu 
    290                 295                 300                 


Asn His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp 
305                 310                 315                 320 


Gly Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu 
                325                 330                 335     


Ser Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala 
            340                 345                 350         


Glu Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu 
        355                 360                 365             


Thr Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr 
    370                 375                 380                 


Gly Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe 
385                 390                 395                 400 


Val Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser 
                405                 410                 415     


Gly Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu 
            420                 425                 430         


Ser Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala 
        435                 440                 445             


Met Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp 
    450                 455                 460                 


Leu Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro 
465                 470                 475                 480 


Asp Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg 
                485                 490                 495     


Leu Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met 
            500                 505                 510         


Leu Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu 
        515                 520                 525             


Glu Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln 
    530                 535                 540                 


Ile His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln 
545                 550                 555                 560 


Glu Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys 
                565                 570                 575     


Ile Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val 
            580                 585                 590         


Ala Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr 
        595                 600                 605             


Thr Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val 
    610                 615                 620                 


Cys Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val 
625                 630                 635                 640 


Arg Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val 
                645                 650                 655     


Glu Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp 
            660                 665                 670         


Ile Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys 
        675                 680                 685             


Glu Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile 
    690                 695                 700                 


Ala Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp 
705                 710                 715                 720 


Gly Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly 
                725                 730                 735     


Arg Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr 
            740                 745                 750         


Asp Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly 
        755                 760                 765             


Phe Ser Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala Leu 
    770                 775                 780                 


Val Leu Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile 
785                 790                 795                 800 


Pro Asp His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala 
                805                 810                 815     


Asp Leu Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp 
            820                 825                 830         


Ser Asp Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg 
        835                 840                 845             


Glu Asp Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys 
    850                 855                 860                 


Leu Tyr Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser 
865                 870                 875                 880 


Gly Ser Asp Pro Glu Asp Thr Tyr 
                885             


<210>  6
<211>  3317
<212>  DNA
<213>  Homo sapiens

<400>  6
ctcgcggggg cgcttccacc gattcctcct ctttccctgc cagtcactcc tcagaccctc       60

agccacaccc gctcatccag ggcgagggaa agcgcgggca ttttcccagt gtgctctgcg      120

ggagggctcg ccccacttca ccccttttcc cgccctcctc ccattcggga gactacgact      180

cccagtgtcc tccgcgcgac ggcggcggtg cggacggtgc ccaggtcccg cccctaggct      240

ctgccccgcc cccgcccgca gacgtctgcg cgcgaatgcc gtggcgcgaa cttgggactg      300

cagaggcgcg cctggcggat ctgagtgtgt tgcccgggca gcggcgcgcg ggaccaacgc      360

aaggagcagc tgacagacga agaaaagtgc tggacaggaa gggagaattc tgacgccaac      420

atgcagcgaa gtatcatggc ggcactgaag gagtggaatg gagtggtgtc cgagagtgac      480

tctccggtga agaggccagg gaggaaggcg gcccgggtcc tgggcagcga aggggaagag      540

gaggatgaag cccttagccc tgctaaaggc cagaagcctg ccctggactg ctcacaggtc      600

tccccgcccc gtcctgccac atctcctgag aacaatgctt ccctctctga cacctctccc      660

atggacagtt ccccatcagg gattccgaag cgtcgcacag ctcggaagca gctcccgaaa      720

cggaccattc aggaagtcct ggaagagcag agtgaggacg aggacagaga agccaagagg      780

aagaaggagg aggaagagga gaccccgaaa gaaagcctca cagaggctga agtggccaca      840

gagaaggaag gagaagacgg ggaccagccc accacgcctc ccaagcccct aaagacctcc      900

aaagcagaga ccccgacgga aagcgtttca gagcctgagg tggccacgaa gcaggaactg      960

caggaggagg aagagcagac caagcctccc cgcagagctc ccaagacgct cagcagcttc     1020

ttcacccccc ggaagccagc agtcaaaaaa gaagtgaagg aagaggagcc aggggctcca     1080

ggaaaggagg gagctgctga gggacccctg gatccatctg gttacaatcc tgccaagaac     1140

aactatcatc ccgtggaaga tgcctgctgg aaaccgggcc agaaggttcc ttacctggct     1200

gtggcccgga cgtttgagaa gatcgaggag gtgtctgctc ggctccggat ggtggagacg     1260

ctgagcaact tgctgcgctc cgtggtggcc ctgtcgcctc cagacctcct ccctgtcctc     1320

tacctcagcc tcaaccacct tgggccaccc cagcagggcc tggagcttgg cgtgggtgat     1380

ggtgtccttc tcaaggcagt ggcccaggcc acaggtcggc agctggagtc cgtccgggct     1440

gaggcagccg agaaaggcga cgtggggctg gtggccgaga acagccgcag cacccagagg     1500

ctcatgctgc caccacctcc gctcactgcc tccggggtct tcagcaagtt ccgcgacatc     1560

gccaggctca ctggcagtgc ttccacagcc aagaagatag acatcatcaa aggcctcttt     1620

gtggcctgcc gccactcaga agcccggttc atcgctaggt ccctgagcgg acggctgcgc     1680

cttgggctgg cagagcagtc ggtgctggct gccctctccc aggcagtgag cctcacgccc     1740

ccgggccaag aattcccacc agccatggtg gatgctggga agggcaagac agcagaggcc     1800

agaaagacgt ggctggagga gcaaggcatg atcctgaagc agacgttctg cgaggttccc     1860

gacctggacc gaattatccc cgtgctgctg gagcacggcc tggaacgtct cccggagcac     1920

tgcaagctga gcccagggat tcccctgaaa ccaatgttgg cccatcccac ccggggcatc     1980

agcgaggtcc tgaaacgctt tgaggaggca gctttcacct gcgaatacaa atatgacggg     2040

cagagggcac agatccacgc cctggaaggc ggggaggtga agatcttcag caggaatcag     2100

gaagacaaca ctgggaagta cccggacatc atcagccgca tccccaagat taaactccca     2160

tcggtcacat ccttcatcct ggacaccgaa gccgtggctt gggaccggga aaagaagcag     2220

atccagccat tccaagtgct caccacccgc aaacgcaagg aggtggatgc gtctgagatc     2280

caggtgcagg tgtgtttgta cgccttcgac ctcatctacc tcaatggaga gtccctggta     2340

cgtgagcccc tttcccggcg ccggcagctg ctccgggaga actttgtgga gacagagggc     2400

gagtttgtct tcgccacctc cctggacacc aaggacatcg agcagatcgc cgagttcctg     2460

gagcagtcag tgaaagactc ctgcgagggg ctgatggtga agaccctgga tgttgatgcc     2520

acctacgaga tcgccaagag atcgcacaac tggctcaagc tgaagaagga ctaccttgat     2580

ggcgtgggtg acaccctgga cctggtggtg atcggcgcct acctgggccg ggggaagcgg     2640

gccggccggt acgggggctt cctgctggcc tcctacgacg aggacagtga ggagctgcag     2700

gccatatgca agcttggaac tggcttcagt gatgaggagc tggaggagca tcaccagagc     2760

ctcaaggcgc tggtgctgcc cagcccacgc ccttacgtgc ggatagatgg cgctgtgatt     2820

cccgaccact ggctggaccc cagcgctgtg tgggaggtga agtgcgctga cctctccctc     2880

tctcccatct accctgctgc gcggggcctg gtggatagtg acaagggcat ctcccttcgc     2940

ttccctcggt ttattcgagt ccgtgaagac aagcagccgg agcaggccac caccagtgct     3000

caggtggcct gtttgtaccg gaagcaaagt cagattcaga accaacaagg cgaggactca     3060

ggctctgacc ctgaagatac ctactaagcc ctcgccctcc tagggcctgg gtacagggca     3120

tgagttggac ggaccccagg gttattattg cctttgcttt ttagcaaatc tgctgtggca     3180

ggctgtggat tttgagagtc aggggagggg tgtgtgtgtg agggggtggc ttactccgga     3240

gtctgggatt catcccgtca tttctttcaa taaataatta ttggatagct aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaa                                                    3317


<210>  7
<211>  2048
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  8
<211>  7138
<212>  DNA
<213>  Homo sapiens

<400>  8
tgtgcgaagg aaaccgatgg ggatcggaac cgtagcggtt gagctgctgc tgctacggat       60

atctgacaga agccttcggt ggttgtcggc ctaatgagcg gacggcaaag aacgcttttt      120

cagacgtggg gctcaagtat ctcccgatca tctgggactc cgggttgcag ctccggaact      180

gagcgacctc agagccctgg cagctccaag gcgcctttgc cagcagcagc ggaggctcag      240

ctggagtcgg acgatgatgt gttgcttgtc gcggcgtacg aggctgagcg gcagttgtgt      300

ctagagaatg gcgggttctg cacctccgcg ggcgccctgt ggatttaccc taccaattgc      360

ccagtgcggg actaccagct gcacatttcc cgggctgctc tgttttgcaa tacgctggtg      420

tgtctgccta ccggactggg aaagaccttt attgccgccg tggtcatgta caatttctac      480

cgctggttcc cttcaggaaa ggtggtcttc atggccccaa cgaaaccctt ggtgacacag      540

cagatcgagg cttgctacca ggtgatgggt atcccgcaat cccacatggc cgaaatgaca      600

gggtctacac aagcttccac caggaaggaa atatggtgca gtaagagagt gctttttctt      660

acacctcagg tcatggtaaa tgacctttct agaggagctt gtcccgctgc tgaaataaag      720

tgtttagtta ttgatgaagc tcataaagct ctcggaaact atgcttattg ccaggttgta      780

agagaactag tcaaatatac aaatcacttt agaatcttgg ctctaagtgc cacaccaggt      840

agtgatataa aggctgtgca acaagttatt actaacctgc taattgggca gatagagctt      900

cgttctgaag attctccaga tattttgaca tattctcatg aaagaaaagt tgaaaagctt      960

attgttccgc ttggtgaaga acttgcagcc atccaaaaga cctatatcca gattttggaa     1020

tcatttgctc gttctttgat tcagaggaat gttttgatga gaagggatat cccaaatcta     1080

acaaaatatc agataattct ggcaagagat cagtttagga aaaacccatc tccgaatatt     1140

gtgggaatac aacaaggcat aatcgaggga gagtttgcta tttgtattag tttatatcat     1200

ggttatgaat tattgcagca aatgggaatg agatcattat atttcttcct ttgtggaatt     1260

atggatggaa ctaaagggat gacacggtca aaaaatgaac ttggccgaaa tgaagacttc     1320

atgaaactct ataatcatct agagtgtatg tttgcacgta cacgtagtac ttcagcaaat     1380

ggtatttctg ctatccaaca aggagataaa aataaaaaat ttgtttatag tcatccaaag     1440

ttaaagaaat tagaagaagt tgtaattgaa cacttcaagt catggaatgc tgaaaacact     1500

actgaaaaga aacgtgatga gacccgagtt atgatcttct cttcatttcg agatagtgtt     1560

caagaaattg cagaaatgct ttcacagcat cagccaatta ttagagtaat gacttttgtc     1620

ggccatgcct cagggaaaag cacgaagggt tttacccaga aggagcaact ggaggtagtg     1680

aaacagtttc gtgacggtgg ttacaacacg ctggtttcta cctgtgtggg tgaagaaggt     1740

ttggatatag gagaagttga tcttataata tgttttgatt cccagaagag cccaattcgt     1800

cttgtacaac gaatgggtag aactggccgt aaacgtcaag gcaggatagt tattatcctt     1860

tctgaaggac gagaggaacg tatttataat cagagtcagt ccaacaaaag aagtatatat     1920

aaagctattt caagtaacag gcaggtcctt catttttacc aaagaagtcc acgaatggtt     1980

cctgatggaa tcaacccaaa attacacaaa atgttcatca cacatggtgt ctatgaacca     2040

gagaagcctt ctcggaactt gcagcgaaag tcatctatct tttcctatag ggatggaatg     2100

aggcaaagta gcctaaagaa agattggttc ttatcagaag aagaatttaa attatggaac     2160

agactttata gattaaggga cagtgatgaa attaaagaga taacattgcc tcaagttcag     2220

ttttcttctt tacaaaatga ggaaaacaaa ccagctcaag aatcaaccac tggaattcat     2280

caactctctc tctctgaatg gagactgtgg caagatcatc ctttgcctac acatcaagtt     2340

gatcactcag atcgatgccg ccattttata ggccttatgc aaatgataga gggaatgaga     2400

cacgaagagg gagaatgcag ctatgaattg gaagttgaat cttatttaca aatggaagat     2460

gttacctcaa catttattgc tcccaggaat gaatctaata atcttgccag tgacaccttt     2520

atcactcaca agaaatcgtc atttataaag aacataaatc aaggcagttc atcctcagtg     2580

atagaatctg atgaagaatg tgctgaaatt gttaaacaaa ctcatatcaa acctactaaa     2640

attgtttctt taaagaaaaa agtgtctaaa gaaataaaaa aagatcagct taaaaaagaa     2700

aataatcacg gtattataga ttctgtagat aatgacagaa attccactgt tgaaaatatt     2760

tttcaagaag acctaccaaa tgataaaagg acatcagata cagatgaaat tgctgccaca     2820

tgtactatta atgaaaatgt tattaaagaa ccgtgtgtgt tattaacaga gtgtcagttt     2880

acaaataaat ccactagttc acttgctgga aatgttttag attctggtta taacagtttc     2940

aatgatgaaa aatctgtttc atctaactta tttcttccat tcgaagaaga gctttatatt     3000

gttagaacag atgaccaatt ttataattgt cactcattga caaaagaggt actagctaat     3060

gtagagagat ttttatctta ttctcctccg cctctcagtg gactctcaga cttggaatat     3120

gaaattgcta agggtactgc acttgagaat ttgcttttct taccctgtgc agagcattta     3180

cgaagtgata aatgcacctg tttgctgtca cattcagctg tgaattctca acagaattta     3240

gaattgaatt cacttaaatg tataaattat ccatctgaaa aaagttgcct ttatgatata     3300

cctaatgata atatttctga tgagccaagt ctctgtgact gtgatgtaca taaacataat     3360

caaaatgaaa atttagtacc taacaatcgt gttcaaatac acagaagccc tgcacagaat     3420

ttagttggag agaacaatca tgatgttgat aacagtgacc tcccagtatt gtccactgat     3480

caagatgaaa gtttgctgtt atttgaagat gttaatacag agttcgacga tgtgagtctt     3540

tcacccttga acagtaaaag cgaatcttta cctgtgtcag acaaaactgc tattagtgaa     3600

acgcctctgg tctctcagtt cttaatttct gatgaacttt tgttggacaa taattctgaa     3660

ctccaagatc aaatcacccg tgatgctaat agttttaaat ctcgtgatca gagaggtgta     3720

caggaagaaa aagtgaagaa tcatgaggat atttttgatt gctctaggga tttattttct     3780

gttacctttg atttaggatt ctgtagtcca gattctgatg atgaaatatt ggaacataca     3840

tcagatagca atagacctct agatgatcta tatggaaggt atttggaaat taaggagata     3900

agtgatgcaa attatgtttc gaatcaagca ctaataccaa gagatcatag taaaaatttt     3960

actagtggaa ctgttattat cccatcaaat gaagatatgc agaatccaaa ttatgtacat     4020

ttgccactga gtgcagcaaa aaatgaagaa ttgttatctc ctggttattc tcagttttct     4080

ttaccagtgc aaaaaaaagt tatgagtaca ccactctcta aatcaaacac attgaactca     4140

ttttctaaga taagaaagga aatacttaag acaccagatt ctagtaagga aaaagtaaac     4200

ctacaaagat tcaaagaagc attgaattca acttttgatt attcagaatt ttctctagaa     4260

aagtctaaaa gcagtggtcc aatgtatctg cataaatcct gtcattctgt tgaagatgga     4320

caattattaa caagtaacga aagtgaagat gacgagattt tccgaagaaa agttaaaaga     4380

gcaaaaggaa atgttttaaa ctctcctgag gatcagaaaa atagtgaagt tgattctcca     4440

cttcatgctg tcaaaaagcg cagatttcct ataaacagat cagaattatc atctagtgat     4500

gagagtgaga attttcccaa accatgttca caattagaag acttcaaggt ttgtaacggg     4560

aatgccagaa gaggcatcaa agtcccaaag agacagagtc acttaaagca tgtagctagg     4620

aagtttttag atgatgaagc agaactttct gaagaagatg cagaatatgt ttcatcagat     4680

gaaaatgatg agtcagaaaa tgaacaagat tcctcattac ttgacttttt aaatgatgaa     4740

actcaacttt cacaggctat aaatgattct gaaatgagag ctatttacat gaaatctttg     4800

cgtagtccaa tgatgaacaa taagtacaaa atgattcata agacacataa aaacataaac     4860

attttctcgc agattcctga acaagatgaa acctatttag aggatagttt ttgtgttgat     4920

gaagaggagt cttgcaaagg ccaatcaagt gaagaagaag tttgtgttga ttttaactta     4980

ataactgatg attgctttgc aaatagtaaa aagtataaaa ctcgacgtgc agtaatgcta     5040

aaagaaatga tggaacaaaa ttgtgcacat tcaaaaaaga aattatccag aattatttta     5100

ccagatgatt caagtgagga ggagaacaat gtaaatgata aaagagaatc taatattgcg     5160

gttaacccaa gcactgttaa gaagaacaaa caacaggacc attgtttaaa ttcagtgcct     5220

tctggatctt ctgcgcagtc caaggtgcgt tctactccaa gagttaatcc attagcaaag     5280

cagagcaaac agacatcgct gaatttaaag gatacaattt ccgaagtctc agacttcaaa     5340

cctcagaatc ataatgaagt ccagtctacc acaccaccct tcactactgt tgattcacag     5400

aaagactgta gaaaatttcc agttccacag aaggatggta gtgctttgga ggattctagc     5460

acttcagggg catcctgttc caagtcaaga ccacatttag ctgggacaca tacttctctt     5520

agacttccgc aggaaggaaa aggaacctgt attcttgtag gtggtcatga aatcacttct     5580

ggattagaag taatttcttc cctaagagca attcatgggt tgcaagtaga agtttgtcct     5640

cttaatggct gtgattacat cgtgagtaat cgcatggtgg tggaaaggag gtctcaatct     5700

gagatgttaa atagtgtcaa taagaacaag ttcattgagc agatccagca cctgcagagt     5760

atgtttgaaa gaatatgtgt gattgtggaa aaggacagag aaaaaacagg agacacatca     5820

aggatgttta ggagaacaaa gagctatgac agcctgctga ctaccttaat tggcgctgga     5880

atccgaattc ttttcagttc ctgccaagaa gaaaccgcag atttgctaaa ggaactgtct     5940

ttagtggaac aaagaaagaa tgttggtatt catgttccaa cagtggtgaa tagtaataaa     6000

agtgaggcac tccagtttta tttaagtatt cccaatataa gttatataac tgcattaaat     6060

atgtgtcacc agttttcatc tgtgaaaagg atggctaaca gctcacttca agaaatctcc     6120

atgtatgcac aagtaactca tcagaaggct gaggagatct atagatatat tcactatgta     6180

tttgacatac aaatgttacc aaatgatctt aaccaagata gactgaaatc tgatatataa     6240

tcaagctgct caagatgggg ttttcaaaga cctctcacaa tattaaatgc acttcaataa     6300

tcattgctgt tttatgttta tttgtaaata agagaatatt ttatttaaat attttatatt     6360

gtatacattt ttatttatag attatagaaa ttattaaaaa agaaaaatct gatgttcagt     6420

gatcattttg actagattat aaaactaatt tttcttatta aataaaacaa ggtttattaa     6480

aagtgttact aaggatagtt taagaaagta aaagctaagc tagagatata ctttggaatg     6540

tttcccaaaa ttaaagttgt actgttgtga taaatagtaa agttgacatg tctatgacta     6600

cagccaactt gtcgattttc cctatgtgta gatagtatac ttttaagtgt actgattcta     6660

aatacatgta cttggtaagg tgtgggtgat gggtgggttg tgagataaat gacccagtaa     6720

ctaggaaagt agaaaactta actgaatgtt tatctgacca aaggtgtgtc ccagttaagt     6780

actgtcaaat ctattaatat gaactctgat atggtttggc tgtgtcccca accaaaatct     6840

catcttgact tgtaatctga attataatcc caatatattg gggagggacc tcctggaacg     6900

tgattagctc atgggggcgg ttcccccatg ctgttctagt gatagttctc agaggatctg     6960

atggttttat aagcttttcc tctgttcact ctgcagttct cttgcctact gccatgtgga     7020

aaaggaaacg tttgcttccc ctccaccatg attgtaagtt cccgaggcct ccccagccat     7080

gcaggactgt gagtcaatta aacatctttt ccttataaat taaaaaaaaa aaaaaaaa       7138


<210>  9
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Lys 
            660                 665                 


<210>  10
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  10
tgtgcgaagg aaaccgatgg ggatcggaac cgtagcggtt gagctgctgc tgctacggat       60

atctgacaga agccttcggt ggttgtcggc ctaatgagcg gacggcaaag aacgcttttt      120

cagacgtggg gctcaagtat ctcccgatca tctgggactc cgggttgcag ctccggaact      180

gagcgacctc agagccctgg cagctccaag gcgcctttgc cagcagcagc ggaggctcag      240

ctggagtcgg acgatgatgt gttgcttgtc gcggcgtacg aggctgagcg gcagttgtgt      300

ctagagaatg gcgggttctg cacctccgcg ggcgccctgt ggatttaccc taccaattgc      360

ccagtgcggg actaccagct gcacatttcc cgggctgctc tgttttgcaa tacgctggtg      420

tgtctgccta ccggactggg aaagaccttt attgccgccg tggtcatgta caatttctac      480

cgctggttcc cttcaggaaa ggtggtcttc atggccccaa cgaaaccctt ggtgacacag      540

cagatcgagg cttgctacca ggtgatgggt atcccgcaat cccacatggc cgaaatgaca      600

gggtctacac aagcttccac caggaaggaa atatggtgca gtaagagagt gctttttctt      660

acacctcagg tcatggtaaa tgacctttct agaggagctt gtcccgctgc tgaaataaag      720

tgtttagtta ttgatgaagc tcataaagct ctcggaaact atgcttattg ccaggttgta      780

agagaactag tcaaatatac aaatcacttt agaatcttgg ctctaagtgc cacaccaggt      840

agtgatataa aggctgtgca acaagttatt actaacctgc taattgggca gatagagctt      900

cgttctgaag attctccaga tattttgaca tattctcatg aaagaaaagt tgaaaagctt      960

attgttccgc ttggtgaaga acttgcagcc atccaaaaga cctatatcca gattttggaa     1020

tcatttgctc gttctttgat tcagaggaat gttttgatga gaagggatat cccaaatcta     1080

acaaaatatc agataattct ggcaagagat cagtttagga aaaacccatc tccgaatatt     1140

gtgggaatac aacaaggcat aatcgaggga gagtttgcta tttgtattag tttatatcat     1200

ggttatgaat tattgcagca aatgggaatg agatcattat atttcttcct ttgtggaatt     1260

atggatggaa ctaaagggat gacacggtca aaaaatgaac ttggccgaaa tgaagacttc     1320

atgaaactct ataatcatct agagtgtatg tttgcacgta cacgtagtac ttcagcaaat     1380

ggtatttctg ctatccaaca aggagataaa aataaaaaat ttgtttatag tcatccaaag     1440

ttaaagaaat tagaagaagt tgtaattgaa cacttcaagt catggaatgc tgaaaacact     1500

actgaaaaga aacgtgatga gacccgagtt atgatcttct cttcatttcg agatagtgtt     1560

caagaaattg cagaaatgct ttcacagcat cagccaatta ttagagtaat gacttttgtc     1620

ggccatgcct cagggaaaag cacgaagggt tttacccaga aggagcaact ggaggtagtg     1680

aaacagtttc gtgacggtgg ttacaacacg ctggtttcta cctgtgtggg tgaagaaggt     1740

ttggatatag gagaagttga tcttataata tgttttgatt cccagaagag cccaattcgt     1800

cttgtacaac gaatgggtag aactggccgt aaacgtcaag gcaggatagt tattatcctt     1860

tctgaaggac gagaggaacg tatttataat cagagtcagt ccaacaaaag aagtatatat     1920

aaagctattt caagtaacag gcaggtcctt catttttacc aaagaagtcc acgaatggtt     1980

cctgatggaa tcaacccaaa attacacaaa atgttcatca cacatggtgt ctatgaacca     2040

gagaagcctt ctcggaactt gcagcgaaag tcatctatct tttcctatag ggatggtaaa     2100

taaattttgc atttgacaca tgcaaaaaaa aaaaaaaaa                            2139


<210>  11
<211>  2022
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Ala Val Gln Gln Val Ile Thr Asn Leu Leu Ile Gly Gln 
225                 230                 235                 240 


Ile Glu Leu Arg Ser Glu Asp Ser Pro Asp Ile Leu Thr Tyr Ser His 
                245                 250                 255     


Glu Arg Lys Val Glu Lys Leu Ile Val Pro Leu Gly Glu Glu Leu Ala 
            260                 265                 270         


Ala Ile Gln Lys Thr Tyr Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser 
        275                 280                 285             


Leu Ile Gln Arg Asn Val Leu Met Arg Arg Asp Ile Pro Asn Leu Thr 
    290                 295                 300                 


Lys Tyr Gln Ile Ile Leu Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser 
305                 310                 315                 320 


Pro Asn Ile Val Gly Ile Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala 
                325                 330                 335     


Ile Cys Ile Ser Leu Tyr His Gly Tyr Glu Leu Leu Gln Gln Met Gly 
            340                 345                 350         


Met Arg Ser Leu Tyr Phe Phe Leu Cys Gly Ile Met Asp Gly Thr Lys 
        355                 360                 365             


Gly Met Thr Arg Ser Lys Asn Glu Leu Gly Arg Asn Glu Asp Phe Met 
    370                 375                 380                 


Lys Leu Tyr Asn His Leu Glu Cys Met Phe Ala Arg Thr Arg Ser Thr 
385                 390                 395                 400 


Ser Ala Asn Gly Ile Ser Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys 
                405                 410                 415     


Phe Val Tyr Ser His Pro Lys Leu Lys Lys Leu Glu Glu Val Val Ile 
            420                 425                 430         


Glu His Phe Lys Ser Trp Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg 
        435                 440                 445             


Asp Glu Thr Arg Val Met Ile Phe Ser Ser Phe Arg Asp Ser Val Gln 
    450                 455                 460                 


Glu Ile Ala Glu Met Leu Ser Gln His Gln Pro Ile Ile Arg Val Met 
465                 470                 475                 480 


Thr Phe Val Gly His Ala Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln 
                485                 490                 495     


Lys Glu Gln Leu Glu Val Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn 
            500                 505                 510         


Thr Leu Val Ser Thr Cys Val Gly Glu Glu Gly Leu Asp Ile Gly Glu 
        515                 520                 525             


Val Asp Leu Ile Ile Cys Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu 
    530                 535                 540                 


Val Gln Arg Met Gly Arg Thr Gly Arg Lys Arg Gln Gly Arg Ile Val 
545                 550                 555                 560 


Ile Ile Leu Ser Glu Gly Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln 
                565                 570                 575     


Ser Asn Lys Arg Ser Ile Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val 
            580                 585                 590         


Leu His Phe Tyr Gln Arg Ser Pro Arg Met Val Pro Asp Gly Ile Asn 
        595                 600                 605             


Pro Lys Leu His Lys Met Phe Ile Thr His Gly Val Tyr Glu Pro Glu 
    610                 615                 620                 


Lys Pro Ser Arg Asn Leu Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg 
625                 630                 635                 640 


Asp Gly Met Arg Gln Ser Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu 
                645                 650                 655     


Glu Glu Phe Lys Leu Trp Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp 
            660                 665                 670         


Glu Ile Lys Glu Ile Thr Leu Pro Gln Val Gln Phe Ser Ser Leu Gln 
        675                 680                 685             


Asn Glu Glu Asn Lys Pro Ala Gln Glu Ser Thr Thr Gly Ile His Gln 
    690                 695                 700                 


Leu Ser Leu Ser Glu Trp Arg Leu Trp Gln Asp His Pro Leu Pro Thr 
705                 710                 715                 720 


His Gln Val Asp His Ser Asp Arg Cys Arg His Phe Ile Gly Leu Met 
                725                 730                 735     


Gln Met Ile Glu Gly Met Arg His Glu Glu Gly Glu Cys Ser Tyr Glu 
            740                 745                 750         


Leu Glu Val Glu Ser Tyr Leu Gln Met Glu Asp Val Thr Ser Thr Phe 
        755                 760                 765             


Ile Ala Pro Arg Asn Glu Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile 
    770                 775                 780                 


Thr His Lys Lys Ser Ser Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser 
785                 790                 795                 800 


Ser Ser Val Ile Glu Ser Asp Glu Glu Cys Ala Glu Ile Val Lys Gln 
                805                 810                 815     


Thr His Ile Lys Pro Thr Lys Ile Val Ser Leu Lys Lys Lys Val Ser 
            820                 825                 830         


Lys Glu Ile Lys Lys Asp Gln Leu Lys Lys Glu Asn Asn His Gly Ile 
        835                 840                 845             


Ile Asp Ser Val Asp Asn Asp Arg Asn Ser Thr Val Glu Asn Ile Phe 
    850                 855                 860                 


Gln Glu Asp Leu Pro Asn Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile 
865                 870                 875                 880 


Ala Ala Thr Cys Thr Ile Asn Glu Asn Val Ile Lys Glu Pro Cys Val 
                885                 890                 895     


Leu Leu Thr Glu Cys Gln Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala 
            900                 905                 910         


Gly Asn Val Leu Asp Ser Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser 
        915                 920                 925             


Val Ser Ser Asn Leu Phe Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val 
    930                 935                 940                 


Arg Thr Asp Asp Gln Phe Tyr Asn Cys His Ser Leu Thr Lys Glu Val 
945                 950                 955                 960 


Leu Ala Asn Val Glu Arg Phe Leu Ser Tyr Ser Pro Pro Pro Leu Ser 
                965                 970                 975     


Gly Leu Ser Asp Leu Glu Tyr Glu Ile Ala Lys Gly Thr Ala Leu Glu 
            980                 985                 990         


Asn Leu Leu Phe Leu Pro Cys Ala  Glu His Leu Arg Ser  Asp Lys Cys 
        995                 1000                 1005             


Thr Cys  Leu Leu Ser His Ser  Ala Val Asn Ser Gln  Gln Asn Leu 
    1010                 1015                 1020             


Glu Leu  Asn Ser Leu Lys Cys  Ile Asn Tyr Pro Ser  Glu Lys Ser 
    1025                 1030                 1035             


Cys Leu  Tyr Asp Ile Pro Asn  Asp Asn Ile Ser Asp  Glu Pro Ser 
    1040                 1045                 1050             


Leu Cys  Asp Cys Asp Val His  Lys His Asn Gln Asn  Glu Asn Leu 
    1055                 1060                 1065             


Val Pro  Asn Asn Arg Val Gln  Ile His Arg Ser Pro  Ala Gln Asn 
    1070                 1075                 1080             


Leu Val  Gly Glu Asn Asn His  Asp Val Asp Asn Ser  Asp Leu Pro 
    1085                 1090                 1095             


Val Leu  Ser Thr Asp Gln Asp  Glu Ser Leu Leu Leu  Phe Glu Asp 
    1100                 1105                 1110             


Val Asn  Thr Glu Phe Asp Asp  Val Ser Leu Ser Pro  Leu Asn Ser 
    1115                 1120                 1125             


Lys Ser  Glu Ser Leu Pro Val  Ser Asp Lys Thr Ala  Ile Ser Glu 
    1130                 1135                 1140             


Thr Pro  Leu Val Ser Gln Phe  Leu Ile Ser Asp Glu  Leu Leu Leu 
    1145                 1150                 1155             


Asp Asn  Asn Ser Glu Leu Gln  Asp Gln Ile Thr Arg  Asp Ala Asn 
    1160                 1165                 1170             


Ser Phe  Lys Ser Arg Asp Gln  Arg Gly Val Gln Glu  Glu Lys Val 
    1175                 1180                 1185             


Lys Asn  His Glu Asp Ile Phe  Asp Cys Ser Arg Asp  Leu Phe Ser 
    1190                 1195                 1200             


Val Thr  Phe Asp Leu Gly Phe  Cys Ser Pro Asp Ser  Asp Asp Glu 
    1205                 1210                 1215             


Ile Leu  Glu His Thr Ser Asp  Ser Asn Arg Pro Leu  Asp Asp Leu 
    1220                 1225                 1230             


Tyr Gly  Arg Tyr Leu Glu Ile  Lys Glu Ile Ser Asp  Ala Asn Tyr 
    1235                 1240                 1245             


Val Ser  Asn Gln Ala Leu Ile  Pro Arg Asp His Ser  Lys Asn Phe 
    1250                 1255                 1260             


Thr Ser  Gly Thr Val Ile Ile  Pro Ser Asn Glu Asp  Met Gln Asn 
    1265                 1270                 1275             


Pro Asn  Tyr Val His Leu Pro  Leu Ser Ala Ala Lys  Asn Glu Glu 
    1280                 1285                 1290             


Leu Leu  Ser Pro Gly Tyr Ser  Gln Phe Ser Leu Pro  Val Gln Lys 
    1295                 1300                 1305             


Lys Val  Met Ser Thr Pro Leu  Ser Lys Ser Asn Thr  Leu Asn Ser 
    1310                 1315                 1320             


Phe Ser  Lys Ile Arg Lys Glu  Ile Leu Lys Thr Pro  Asp Ser Ser 
    1325                 1330                 1335             


Lys Glu  Lys Val Asn Leu Gln  Arg Phe Lys Glu Ala  Leu Asn Ser 
    1340                 1345                 1350             


Thr Phe  Asp Tyr Ser Glu Phe  Ser Leu Glu Lys Ser  Lys Ser Ser 
    1355                 1360                 1365             


Gly Pro  Met Tyr Leu His Lys  Ser Cys His Ser Val  Glu Asp Gly 
    1370                 1375                 1380             


Gln Leu  Leu Thr Ser Asn Glu  Ser Glu Asp Asp Glu  Ile Phe Arg 
    1385                 1390                 1395             


Arg Lys  Val Lys Arg Ala Lys  Gly Asn Val Leu Asn  Ser Pro Glu 
    1400                 1405                 1410             


Asp Gln  Lys Asn Ser Glu Val  Asp Ser Pro Leu His  Ala Val Lys 
    1415                 1420                 1425             


Lys Arg  Arg Phe Pro Ile Asn  Arg Ser Glu Leu Ser  Ser Ser Asp 
    1430                 1435                 1440             


Glu Ser  Glu Asn Phe Pro Lys  Pro Cys Ser Gln Leu  Glu Asp Phe 
    1445                 1450                 1455             


Lys Val  Cys Asn Gly Asn Ala  Arg Arg Gly Ile Lys  Val Pro Lys 
    1460                 1465                 1470             


Arg Gln  Ser His Leu Lys His  Val Ala Arg Lys Phe  Leu Asp Asp 
    1475                 1480                 1485             


Glu Ala  Glu Leu Ser Glu Glu  Asp Ala Glu Tyr Val  Ser Ser Asp 
    1490                 1495                 1500             


Glu Asn  Asp Glu Ser Glu Asn  Glu Gln Asp Ser Ser  Leu Leu Asp 
    1505                 1510                 1515             


Phe Leu  Asn Asp Glu Thr Gln  Leu Ser Gln Ala Ile  Asn Asp Ser 
    1520                 1525                 1530             


Glu Met  Arg Ala Ile Tyr Met  Lys Ser Leu Arg Ser  Pro Met Met 
    1535                 1540                 1545             


Asn Asn  Lys Tyr Lys Met Ile  His Lys Thr His Lys  Asn Ile Asn 
    1550                 1555                 1560             


Ile Phe  Ser Gln Ile Pro Glu  Gln Asp Glu Thr Tyr  Leu Glu Asp 
    1565                 1570                 1575             


Ser Phe  Cys Val Asp Glu Glu  Glu Ser Cys Lys Gly  Gln Ser Ser 
    1580                 1585                 1590             


Glu Glu  Glu Val Cys Val Asp  Phe Asn Leu Ile Thr  Asp Asp Cys 
    1595                 1600                 1605             


Phe Ala  Asn Ser Lys Lys Tyr  Lys Thr Arg Arg Ala  Val Met Leu 
    1610                 1615                 1620             


Lys Glu  Met Met Glu Gln Asn  Cys Ala His Ser Lys  Lys Lys Leu 
    1625                 1630                 1635             


Ser Arg  Ile Ile Leu Pro Asp  Asp Ser Ser Glu Glu  Glu Asn Asn 
    1640                 1645                 1650             


Val Asn  Asp Lys Arg Glu Ser  Asn Ile Ala Val Asn  Pro Ser Thr 
    1655                 1660                 1665             


Val Lys  Lys Asn Lys Gln Gln  Asp His Cys Leu Asn  Ser Val Pro 
    1670                 1675                 1680             


Ser Gly  Ser Ser Ala Gln Ser  Lys Val Arg Ser Thr  Pro Arg Val 
    1685                 1690                 1695             


Asn Pro  Leu Ala Lys Gln Ser  Lys Gln Thr Ser Leu  Asn Leu Lys 
    1700                 1705                 1710             


Asp Thr  Ile Ser Glu Val Ser  Asp Phe Lys Pro Gln  Asn His Asn 
    1715                 1720                 1725             


Glu Val  Gln Ser Thr Thr Pro  Pro Phe Thr Thr Val  Asp Ser Gln 
    1730                 1735                 1740             


Lys Asp  Cys Arg Lys Phe Pro  Val Pro Gln Lys Asp  Gly Ser Ala 
    1745                 1750                 1755             


Leu Glu  Asp Ser Ser Thr Ser  Gly Ala Ser Cys Ser  Lys Ser Arg 
    1760                 1765                 1770             


Pro His  Leu Ala Gly Thr His  Thr Ser Leu Arg Leu  Pro Gln Glu 
    1775                 1780                 1785             


Gly Lys  Gly Thr Cys Ile Leu  Val Gly Gly His Glu  Ile Thr Ser 
    1790                 1795                 1800             


Gly Leu  Glu Val Ile Ser Ser  Leu Arg Ala Ile His  Gly Leu Gln 
    1805                 1810                 1815             


Val Glu  Val Cys Pro Leu Asn  Gly Cys Asp Tyr Ile  Val Ser Asn 
    1820                 1825                 1830             


Arg Met  Val Val Glu Arg Arg  Ser Gln Ser Glu Met  Leu Asn Ser 
    1835                 1840                 1845             


Val Asn  Lys Asn Lys Phe Ile  Glu Gln Ile Gln His  Leu Gln Ser 
    1850                 1855                 1860             


Met Phe  Glu Arg Ile Cys Val  Ile Val Glu Lys Asp  Arg Glu Lys 
    1865                 1870                 1875             


Thr Gly  Asp Thr Ser Arg Met  Phe Arg Arg Thr Lys  Ser Tyr Asp 
    1880                 1885                 1890             


Ser Leu  Leu Thr Thr Leu Ile  Gly Ala Gly Ile Arg  Ile Leu Phe 
    1895                 1900                 1905             


Ser Ser  Cys Gln Glu Glu Thr  Ala Asp Leu Leu Lys  Glu Leu Ser 
    1910                 1915                 1920             


Leu Val  Glu Gln Arg Lys Asn  Val Gly Ile His Val  Pro Thr Val 
    1925                 1930                 1935             


Val Asn  Ser Asn Lys Ser Glu  Ala Leu Gln Phe Tyr  Leu Ser Ile 
    1940                 1945                 1950             


Pro Asn  Ile Ser Tyr Ile Thr  Ala Leu Asn Met Cys  His Gln Phe 
    1955                 1960                 1965             


Ser Ser  Val Lys Arg Met Ala  Asn Ser Ser Leu Gln  Glu Ile Ser 
    1970                 1975                 1980             


Met Tyr  Ala Gln Val Thr His  Gln Lys Ala Glu Glu  Ile Tyr Arg 
    1985                 1990                 1995             


Tyr Ile  His Tyr Val Phe Asp  Ile Gln Met Leu Pro  Asn Asp Leu 
    2000                 2005                 2010             


Asn Gln  Asp Arg Leu Lys Ser  Asp Ile 
    2015                 2020         


<210>  12
<211>  7053
<212>  DNA
<213>  Homo sapiens

<400>  12
ccagagtttt gtgcgaagga aaccgatggg gatcggaacc gtagcggttg agctgctgct       60

gctacggata tctgacagaa gccttcggtg gttgtcggcc taatgagcgg acggcaaaga      120

acgctttttc agacgtgggg ctcaagtatc tcccgatcat ctgggactcc gggttgcagc      180

tccggaactg agcgacctca gagccctggc agctccaagg cgcctttgcc agcagcagcg      240

gaggctcagc tggagtcgga cgatgatgtg ttgcttgtcg cggcgtacga ggctgagcgg      300

cagttgtgtc tagagaatgg cgggttctgc acctccgcgg gcgccctgtg gatttaccct      360

accaattgcc cagtgcggga ctaccagctg cacatttccc gggctgctct gttttgcaat      420

acgctggtgt gtctgcctac cggactggga aagaccttta ttgccgccgt ggtcatgtac      480

aatttctacc gctggttccc ttcaggaaag gtggtcttca tggccccaac gaaacccttg      540

gtgacacagc agatcgaggc ttgctaccag gtgatgggta tcccgcaatc ccacatggcc      600

gaaatgacag ggtctacaca agcttccacc aggaaggaaa tatggtgcag taagagagtg      660

ctttttctta cacctcaggt catggtaaat gacctttcta gaggagcttg tcccgctgct      720

gaaataaagt gtttagttat tgatgaagct cataaagctc tcggaaacta tgcttattgc      780

caggctgtgc aacaagttat tactaacctg ctaattgggc agatagagct tcgttctgaa      840

gattctccag atattttgac atattctcat gaaagaaaag ttgaaaagct tattgttccg      900

cttggtgaag aacttgcagc catccaaaag acctatatcc agattttgga atcatttgct      960

cgttctttga ttcagaggaa tgttttgatg agaagggata tcccaaatct aacaaaatat     1020

cagataattc tggcaagaga tcagtttagg aaaaacccat ctccgaatat tgtgggaata     1080

caacaaggca taatcgaggg agagtttgct atttgtatta gtttatatca tggttatgaa     1140

ttattgcagc aaatgggaat gagatcatta tatttcttcc tttgtggaat tatggatgga     1200

actaaaggga tgacacggtc aaaaaatgaa cttggccgaa atgaagactt catgaaactc     1260

tataatcatc tagagtgtat gtttgcacgt acacgtagta cttcagcaaa tggtatttct     1320

gctatccaac aaggagataa aaataaaaaa tttgtttata gtcatccaaa gttaaagaaa     1380

ttagaagaag ttgtaattga acacttcaag tcatggaatg ctgaaaacac tactgaaaag     1440

aaacgtgatg agacccgagt tatgatcttc tcttcatttc gagatagtgt tcaagaaatt     1500

gcagaaatgc tttcacagca tcagccaatt attagagtaa tgacttttgt cggccatgcc     1560

tcagggaaaa gcacgaaggg ttttacccag aaggagcaac tggaggtagt gaaacagttt     1620

cgtgacggtg gttacaacac gctggtttct acctgtgtgg gtgaagaagg tttggatata     1680

ggagaagttg atcttataat atgttttgat tcccagaaga gcccaattcg tcttgtacaa     1740

cgaatgggta gaactggccg taaacgtcaa ggcaggatag ttattatcct ttctgaagga     1800

cgagaggaac gtatttataa tcagagtcag tccaacaaaa gaagtatata taaagctatt     1860

tcaagtaaca ggcaggtcct tcatttttac caaagaagtc cacgaatggt tcctgatgga     1920

atcaacccaa aattacacaa aatgttcatc acacatggtg tctatgaacc agagaagcct     1980

tctcggaact tgcagcgaaa gtcatctatc ttttcctata gggatggaat gaggcaaagt     2040

agcctaaaga aagattggtt cttatcagaa gaagaattta aattatggaa cagactttat     2100

agattaaggg acagtgatga aattaaagag ataacattgc ctcaagttca gttttcttct     2160

ttacaaaatg aggaaaacaa accagctcaa gaatcaacca ctggaattca tcaactctct     2220

ctctctgaat ggagactgtg gcaagatcat cctttgccta cacatcaagt tgatcactca     2280

gatcgatgcc gccattttat aggccttatg caaatgatag agggaatgag acacgaagag     2340

ggagaatgca gctatgaatt ggaagttgaa tcttatttac aaatggaaga tgttacctca     2400

acatttattg ctcccaggaa tgaatctaat aatcttgcca gtgacacctt tatcactcac     2460

aagaaatcgt catttataaa gaacataaat caaggcagtt catcctcagt gatagaatct     2520

gatgaagaat gtgctgaaat tgttaaacaa actcatatca aacctactaa aattgtttct     2580

ttaaagaaaa aagtgtctaa agaaataaaa aaagatcagc ttaaaaaaga aaataatcac     2640

ggtattatag attctgtaga taatgacaga aattccactg ttgaaaatat ttttcaagaa     2700

gacctaccaa atgataaaag gacatcagat acagatgaaa ttgctgccac atgtactatt     2760

aatgaaaatg ttattaaaga accgtgtgtg ttattaacag agtgtcagtt tacaaataaa     2820

tccactagtt cacttgctgg aaatgtttta gattctggtt ataacagttt caatgatgaa     2880

aaatctgttt catctaactt atttcttcca ttcgaagaag agctttatat tgttagaaca     2940

gatgaccaat tttataattg tcactcattg acaaaagagg tactagctaa tgtagagaga     3000

tttttatctt attctcctcc gcctctcagt ggactctcag acttggaata tgaaattgct     3060

aagggtactg cacttgagaa tttgcttttc ttaccctgtg cagagcattt acgaagtgat     3120

aaatgcacct gtttgctgtc acattcagct gtgaattctc aacagaattt agaattgaat     3180

tcacttaaat gtataaatta tccatctgaa aaaagttgcc tttatgatat acctaatgat     3240

aatatttctg atgagccaag tctctgtgac tgtgatgtac ataaacataa tcaaaatgaa     3300

aatttagtac ctaacaatcg tgttcaaata cacagaagcc ctgcacagaa tttagttgga     3360

gagaacaatc atgatgttga taacagtgac ctcccagtat tgtccactga tcaagatgaa     3420

agtttgctgt tatttgaaga tgttaataca gagttcgacg atgtgagtct ttcacccttg     3480

aacagtaaaa gcgaatcttt acctgtgtca gacaaaactg ctattagtga aacgcctctg     3540

gtctctcagt tcttaatttc tgatgaactt ttgttggaca ataattctga actccaagat     3600

caaatcaccc gtgatgctaa tagttttaaa tctcgtgatc agagaggtgt acaggaagaa     3660

aaagtgaaga atcatgagga tatttttgat tgctctaggg atttattttc tgttaccttt     3720

gatttaggat tctgtagtcc agattctgat gatgaaatat tggaacatac atcagatagc     3780

aatagacctc tagatgatct atatggaagg tatttggaaa ttaaggagat aagtgatgca     3840

aattatgttt cgaatcaagc actaatacca agagatcata gtaaaaattt tactagtgga     3900

actgttatta tcccatcaaa tgaagatatg cagaatccaa attatgtaca tttgccactg     3960

agtgcagcaa aaaatgaaga attgttatct cctggttatt ctcagttttc tttaccagtg     4020

caaaaaaaag ttatgagtac accactctct aaatcaaaca cattgaactc attttctaag     4080

ataagaaagg aaatacttaa gacaccagat tctagtaagg aaaaagtaaa cctacaaaga     4140

ttcaaagaag cattgaattc aacttttgat tattcagaat tttctctaga aaagtctaaa     4200

agcagtggtc caatgtatct gcataaatcc tgtcattctg ttgaagatgg acaattatta     4260

acaagtaacg aaagtgaaga tgacgagatt ttccgaagaa aagttaaaag agcaaaagga     4320

aatgttttaa actctcctga ggatcagaaa aatagtgaag ttgattctcc acttcatgct     4380

gtcaaaaagc gcagatttcc tataaacaga tcagaattat catctagtga tgagagtgag     4440

aattttccca aaccatgttc acaattagaa gacttcaagg tttgtaacgg gaatgccaga     4500

agaggcatca aagtcccaaa gagacagagt cacttaaagc atgtagctag gaagttttta     4560

gatgatgaag cagaactttc tgaagaagat gcagaatatg tttcatcaga tgaaaatgat     4620

gagtcagaaa atgaacaaga ttcctcatta cttgactttt taaatgatga aactcaactt     4680

tcacaggcta taaatgattc tgaaatgaga gctatttaca tgaaatcttt gcgtagtcca     4740

atgatgaaca ataagtacaa aatgattcat aagacacata aaaacataaa cattttctcg     4800

cagattcctg aacaagatga aacctattta gaggatagtt tttgtgttga tgaagaggag     4860

tcttgcaaag gccaatcaag tgaagaagaa gtttgtgttg attttaactt aataactgat     4920

gattgctttg caaatagtaa aaagtataaa actcgacgtg cagtaatgct aaaagaaatg     4980

atggaacaaa attgtgcaca ttcaaaaaag aaattatcca gaattatttt accagatgat     5040

tcaagtgagg aggagaacaa tgtaaatgat aaaagagaat ctaatattgc ggttaaccca     5100

agcactgtta agaagaacaa acaacaggac cattgtttaa attcagtgcc ttctggatct     5160

tctgcgcagt ccaaggtgcg ttctactcca agagttaatc cattagcaaa gcagagcaaa     5220

cagacatcgc tgaatttaaa ggatacaatt tccgaagtct cagacttcaa acctcagaat     5280

cataatgaag tccagtctac cacaccaccc ttcactactg ttgattcaca gaaagactgt     5340

agaaaatttc cagttccaca gaaggatggt agtgctttgg aggattctag cacttcaggg     5400

gcatcctgtt ccaagtcaag accacattta gctgggacac atacttctct tagacttccg     5460

caggaaggaa aaggaacctg tattcttgta ggtggtcatg aaatcacttc tggattagaa     5520

gtaatttctt ccctaagagc aattcatggg ttgcaagtag aagtttgtcc tcttaatggc     5580

tgtgattaca tcgtgagtaa tcgcatggtg gtggaaagga ggtctcaatc tgagatgtta     5640

aatagtgtca ataagaacaa gttcattgag cagatccagc acctgcagag tatgtttgaa     5700

agaatatgtg tgattgtgga aaaggacaga gaaaaaacag gagacacatc aaggatgttt     5760

aggagaacaa agagctatga cagcctgctg actaccttaa ttggcgctgg aatccgaatt     5820

cttttcagtt cctgccaaga agaaaccgca gatttgctaa aggaactgtc tttagtggaa     5880

caaagaaaga atgttggtat tcatgttcca acagtggtga atagtaataa aagtgaggca     5940

ctccagtttt atttaagtat tcccaatata agttatataa ctgcattaaa tatgtgtcac     6000

cagttttcat ctgtgaaaag gatggctaac agctcacttc aagaaatctc catgtatgca     6060

caagtaactc atcagaaggc tgaggagatc tatagatata ttcactatgt atttgacata     6120

caaatgttac caaatgatct taaccaagat agactgaaat ctgatatata atcaagctgc     6180

tcaagatggg gttttcaaag acctctcaca atattaaatg cacttcaata atcattgctg     6240

ttttatgttt atttgtaaat aagagaatat tttatttaaa tattttatat tgtatacatt     6300

tttatttata gattatagaa attattaaaa aagaaaaatc tgatgttcag tgatcatttt     6360

gactagatta taaaactaat ttttcttatt aaataaaaca aggtttatta aaagtgttac     6420

taaggatagt ttaagaaagt aaaagctaag ctagagatat actttggaat gtttcccaaa     6480

attaaagttg tactgttgtg ataaatagta aagttgacat gtctatgact acagccaact     6540

tgtcgatttt ccctatgtgt agatagtata cttttaagtg tactgattct aaatacatgt     6600

acttggtaag gtgtgggtga tgggtgggtt gtgagataaa tgacccagta actaggaaag     6660

tagaaaactt aactgaatgt ttatctgacc aaaggtgtgt cccagttaag tactgtcaaa     6720

tctattaata tgaactctga tatggtttgg ctgtgtcccc aaccaaaatc tcatcttgac     6780

ttgtaatctg aattataatc ccaatatatt ggggagggac ctcctggaac gtgattagct     6840

catgggggcg gttcccccat gctgttctag tgatagttct cagaggatct gatggtttta     6900

taagcttttc ctctgttcac tctgcagttc tcttgcctac tgccatgtgg aaaaggaaac     6960

gtttgcttcc cctccaccat gattgtaagt tcccgaggcc tccccagcca tgcaggactg     7020

tgagtcaatt aaacatcttt tccttataaa tta                                  7053


<210>  13
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  14
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu 
    50                  55                  60              


<210>  15
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Val Leu Thr 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
                565                 570                 575     


Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
            660                 665                 670         


Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val 
        675                 680                 685             


Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile Val 
    690                 695                 700                 


Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile 
705                 710                 715                 720 


Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu Asp 
                725                 730                 735     


Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro 
            740                 745                 750         


Gln Ile Pro His Ser His Tyr 
        755                 


<210>  16
<211>  1846
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys Glu 
1               5                   10                  15      


Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met Leu 
            20                  25                  30          


Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys Lys 
        35                  40                  45              


Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser Gln 
    50                  55                  60                  


Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp Thr 
65                  70                  75                  80  


Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn Asn 
                85                  90                  95      


Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met Gly 
            100                 105                 110         


Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn Pro 
        115                 120                 125             


Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly Thr 
    130                 135                 140                 


Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr Ser 
145                 150                 155                 160 


Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn Lys 
                165                 170                 175     


Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr Pro 
            180                 185                 190         


Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala Ala 
        195                 200                 205             


Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln Pro 
    210                 215                 220                 


Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg His 
225                 230                 235                 240 


Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu Pro 
                245                 250                 255     


Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser Ser 
            260                 265                 270         


Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe Cys 
        275                 280                 285             


Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg Trp 
    290                 295                 300                 


Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr Glu 
305                 310                 315                 320 


Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu Trp 
                325                 330                 335     


Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu Asp 
            340                 345                 350         


Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu Trp 
        355                 360                 365             


Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp Gly 
    370                 375                 380                 


Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu Asn 
385                 390                 395                 400 


Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu Ala 
                405                 410                 415     


Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His Ser 
            420                 425                 430         


Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr Tyr 
        435                 440                 445             


Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn Leu 
    450                 455                 460                 


Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg Pro 
465                 470                 475                 480 


Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu His 
                485                 490                 495     


Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr Pro 
            500                 505                 510         


Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln Val 
        515                 520                 525             


Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp Ser 
    530                 535                 540                 


Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys Glu 
545                 550                 555                 560 


Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser Asn 
                565                 570                 575     


Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys Asn 
            580                 585                 590         


Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu Leu 
        595                 600                 605             


Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln Ile 
    610                 615                 620                 


Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn Gln 
625                 630                 635                 640 


Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys Glu 
                645                 650                 655     


Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr Ser 
            660                 665                 670         


Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn Ala 
        675                 680                 685             


Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu Phe 
    690                 695                 700                 


Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu Thr 
705                 710                 715                 720 


Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu Ser 
                725                 730                 735     


Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser Ile 
            740                 745                 750         


Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser Leu 
        755                 760                 765             


Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys Cys 
    770                 775                 780                 


Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His Gly 
785                 790                 795                 800 


Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro Leu 
                805                 810                 815     


Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu Glu 
            820                 825                 830         


Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser Lys 
        835                 840                 845             


Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu Glu 
    850                 855                 860                 


Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser Pro 
865                 870                 875                 880 


Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys Asn 
                885                 890                 895     


Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly Phe 
            900                 905                 910         


Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys Ser 
        915                 920                 925             


Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly Asn 
    930                 935                 940                 


Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr Lys 
                965                 970                 975     


Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met Ser 
            980                 985                 990         


Pro Glu Arg Glu Met Gly Asn Glu  Asn Ile Pro Ser Thr  Val Ser Thr 
        995                 1000                 1005             


Ile Ser  Arg Asn Asn Ile Arg  Glu Asn Val Phe Lys  Glu Ala Ser 
    1010                 1015                 1020             


Ser Ser  Asn Ile Asn Glu Val  Gly Ser Ser Thr Asn  Glu Val Gly 
    1025                 1030                 1035             


Ser Ser  Ile Asn Glu Ile Gly  Ser Ser Asp Glu Asn  Ile Gln Ala 
    1040                 1045                 1050             


Glu Leu  Gly Arg Asn Arg Gly  Pro Lys Leu Asn Ala  Met Leu Arg 
    1055                 1060                 1065             


Leu Gly  Val Leu Gln Pro Glu  Val Tyr Lys Gln Ser  Leu Pro Gly 
    1070                 1075                 1080             


Ser Asn  Cys Lys His Pro Glu  Ile Lys Lys Gln Glu  Tyr Glu Glu 
    1085                 1090                 1095             


Val Val  Gln Thr Val Asn Thr  Asp Phe Ser Pro Tyr  Leu Ile Ser 
    1100                 1105                 1110             


Asp Asn  Leu Glu Gln Pro Met  Gly Ser Ser His Ala  Ser Gln Val 
    1115                 1120                 1125             


Cys Ser  Glu Thr Pro Asp Asp  Leu Leu Asp Asp Gly  Glu Ile Lys 
    1130                 1135                 1140             


Glu Asp  Thr Ser Phe Ala Glu  Asn Asp Ile Lys Glu  Ser Ser Ala 
    1145                 1150                 1155             


Val Phe  Ser Lys Ser Val Gln  Lys Gly Glu Leu Ser  Arg Ser Pro 
    1160                 1165                 1170             


Ser Pro  Phe Thr His Thr His  Leu Ala Gln Gly Tyr  Arg Arg Gly 
    1175                 1180                 1185             


Ala Lys  Lys Leu Glu Ser Ser  Glu Glu Asn Leu Ser  Ser Glu Asp 
    1190                 1195                 1200             


Glu Glu  Leu Pro Cys Phe Gln  His Leu Leu Phe Gly  Lys Val Asn 
    1205                 1210                 1215             


Asn Ile  Pro Ser Gln Ser Thr  Arg His Ser Thr Val  Ala Thr Glu 
    1220                 1225                 1230             


Cys Leu  Ser Lys Asn Thr Glu  Glu Asn Leu Leu Ser  Leu Lys Asn 
    1235                 1240                 1245             


Ser Leu  Asn Asp Cys Ser Asn  Gln Val Ile Leu Ala  Lys Ala Ser 
    1250                 1255                 1260             


Gln Glu  His His Leu Ser Glu  Glu Thr Lys Cys Ser  Ala Ser Leu 
    1265                 1270                 1275             


Phe Ser  Ser Gln Cys Ser Glu  Leu Glu Asp Leu Thr  Ala Asn Thr 
    1280                 1285                 1290             


Asn Thr  Gln Asp Pro Phe Leu  Ile Gly Ser Ser Lys  Gln Met Arg 
    1295                 1300                 1305             


His Gln  Ser Glu Ser Gln Gly  Val Gly Leu Ser Asp  Lys Glu Leu 
    1310                 1315                 1320             


Val Ser  Asp Asp Glu Glu Arg  Gly Thr Gly Leu Glu  Glu Asn Asn 
    1325                 1330                 1335             


Gln Glu  Glu Gln Ser Met Asp  Ser Asn Leu Gly Glu  Ala Ala Ser 
    1340                 1345                 1350             


Gly Cys  Glu Ser Glu Thr Ser  Val Ser Glu Asp Cys  Ser Gly Leu 
    1355                 1360                 1365             


Ser Ser  Gln Ser Asp Ile Leu  Thr Thr Gln Gln Arg  Asp Thr Met 
    1370                 1375                 1380             


Gln His  Asn Leu Ile Lys Leu  Gln Gln Glu Met Ala  Glu Leu Glu 
    1385                 1390                 1395             


Ala Val  Leu Glu Gln His Gly  Ser Gln Pro Ser Asn  Ser Tyr Pro 
    1400                 1405                 1410             


Ser Ile  Ile Ser Asp Ser Ser  Ala Leu Glu Asp Leu  Arg Asn Pro 
    1415                 1420                 1425             


Glu Gln  Ser Thr Ser Glu Lys  Ala Val Leu Thr Ser  Gln Lys Ser 
    1430                 1435                 1440             


Ser Glu  Tyr Pro Ile Ser Gln  Asn Pro Glu Gly Leu  Ser Ala Asp 
    1445                 1450                 1455             


Lys Phe  Glu Val Ser Ala Asp  Ser Ser Thr Ser Lys  Asn Lys Glu 
    1460                 1465                 1470             


Pro Gly  Val Glu Arg Ser Ser  Pro Ser Lys Cys Pro  Ser Leu Asp 
    1475                 1480                 1485             


Asp Arg  Trp Tyr Met His Ser  Cys Ser Gly Ser Leu  Gln Asn Arg 
    1490                 1495                 1500             


Asn Tyr  Pro Ser Gln Glu Glu  Leu Ile Lys Val Val  Asp Val Glu 
    1505                 1510                 1515             


Glu Gln  Gln Leu Glu Glu Ser  Gly Pro His Asp Leu  Thr Glu Thr 
    1520                 1525                 1530             


Ser Tyr  Leu Pro Arg Gln Asp  Leu Glu Gly Thr Pro  Tyr Leu Glu 
    1535                 1540                 1545             


Ser Gly  Ile Ser Leu Phe Ser  Asp Asp Pro Glu Ser  Asp Pro Ser 
    1550                 1555                 1560             


Glu Asp  Arg Ala Pro Glu Ser  Ala Arg Val Gly Asn  Ile Pro Ser 
    1565                 1570                 1575             


Ser Thr  Ser Ala Leu Lys Val  Pro Gln Leu Lys Val  Ala Glu Ser 
    1580                 1585                 1590             


Ala Gln  Ser Pro Ala Ala Ala  His Thr Thr Asp Thr  Ala Gly Tyr 
    1595                 1600                 1605             


Asn Ala  Met Glu Glu Ser Val  Ser Arg Glu Lys Pro  Glu Leu Thr 
    1610                 1615                 1620             


Ala Ser  Thr Glu Arg Val Asn  Lys Arg Met Ser Met  Val Val Ser 
    1625                 1630                 1635             


Gly Leu  Thr Pro Glu Glu Phe  Met Leu Val Tyr Lys  Phe Ala Arg 
    1640                 1645                 1650             


Lys His  His Ile Thr Leu Thr  Asn Leu Ile Thr Glu  Glu Thr Thr 
    1655                 1660                 1665             


His Val  Val Met Lys Thr Asp  Ala Glu Phe Val Cys  Glu Arg Thr 
    1670                 1675                 1680             


Leu Lys  Tyr Phe Leu Gly Ile  Ala Gly Gly Lys Trp  Val Val Ser 
    1685                 1690                 1695             


Tyr Phe  Trp Val Thr Gln Ser  Ile Lys Glu Arg Lys  Met Leu Asn 
    1700                 1705                 1710             


Glu His  Asp Phe Glu Val Arg  Gly Asp Val Val Asn  Gly Arg Asn 
    1715                 1720                 1725             


His Gln  Gly Pro Lys Arg Ala  Arg Glu Ser Gln Asp  Arg Lys Ile 
    1730                 1735                 1740             


Phe Arg  Gly Leu Glu Ile Cys  Cys Tyr Gly Pro Phe  Thr Asn Met 
    1745                 1750                 1755             


Pro Thr  Asp Gln Leu Glu Trp  Met Val Gln Leu Cys  Gly Ala Ser 
    1760                 1765                 1770             


Val Val  Lys Glu Leu Ser Ser  Phe Thr Leu Gly Thr  Gly Val His 
    1775                 1780                 1785             


Pro Ile  Val Val Val Gln Pro  Asp Ala Trp Thr Glu  Asp Asn Gly 
    1790                 1795                 1800             


Phe His  Ala Ile Gly Gln Met  Cys Glu Ala Pro Val  Val Thr Arg 
    1805                 1810                 1815             


Glu Trp  Val Leu Asp Ser Val  Ala Leu Tyr Gln Cys  Gln Glu Leu 
    1820                 1825                 1830             


Asp Thr  Tyr Leu Ile Pro Gln  Ile Pro His Ser His  Tyr 
    1835                 1840                 1845     


<210>  17
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Gly 
    210                 215                 220                 


Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr Ser Val Ser Glu Asp Cys 
225                 230                 235                 240 


Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu Thr Thr Gln Gln Arg Asp 
                245                 250                 255     


Thr Met Gln His Asn Leu Ile Lys Leu Gln Gln Glu Met Ala Glu Leu 
            260                 265                 270         


Glu Ala Val Leu Glu Gln His Gly Ser Gln Pro Ser Asn Ser Tyr Pro 
        275                 280                 285             


Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg Asn Pro Glu 
    290                 295                 300                 


Gln Ser Thr Ser Glu Lys Ala Val Leu Thr Ser Gln Lys Ser Ser Glu 
305                 310                 315                 320 


Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu Ser Ala Asp Lys Phe Glu 
                325                 330                 335     


Val Ser Ala Asp Ser Ser Thr Ser Lys Asn Lys Glu Pro Gly Val Glu 
            340                 345                 350         


Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu Asp Asp Arg Trp Tyr Met 
        355                 360                 365             


His Ser Cys Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln Glu 
    370                 375                 380                 


Glu Leu Ile Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu Ser 
385                 390                 395                 400 


Gly Pro His Asp Leu Thr Glu Thr Ser Tyr Leu Pro Arg Gln Asp Leu 
                405                 410                 415     


Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp Asp 
            420                 425                 430         


Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg Val 
        435                 440                 445             


Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu Lys Val Pro Gln Leu Lys 
    450                 455                 460                 


Val Ala Glu Ser Ala Gln Ser Pro Ala Ala Ala His Thr Thr Asp Thr 
465                 470                 475                 480 


Ala Gly Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro Glu 
                485                 490                 495     


Leu Thr Ala Ser Thr Glu Arg Val Asn Lys Arg Met Ser Met Val Val 
            500                 505                 510         


Ser Gly Leu Thr Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala Arg 
        515                 520                 525             


Lys His His Ile Thr Leu Thr Asn Leu Ile Thr Glu Glu Thr Thr His 
    530                 535                 540                 


Val Val Met Lys Thr Asp Ala Glu Phe Val Cys Glu Arg Thr Leu Lys 
545                 550                 555                 560 


Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp 
                565                 570                 575     


Val Thr Gln Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe 
            580                 585                 590         


Glu Val Arg Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys 
        595                 600                 605             


Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile 
    610                 615                 620                 


Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu Trp 
625                 630                 635                 640 


Met Val Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe 
                645                 650                 655     


Thr Leu Gly Thr Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala 
            660                 665                 670         


Trp Thr Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala 
        675                 680                 685             


Pro Val Val Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln 
    690                 695                 700                 


Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His 
705                 710                 715                 720 


Tyr 
    


<210>  18
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Val Leu Thr 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
                565                 570                 575     


Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
            660                 665                 670         


Thr Gly Cys Pro Pro Asn Cys Gly Cys Ala Ala Arg Cys Leu Asp Arg 
        675                 680                 685             


Gly Gln Trp Leu Pro Cys Asn Trp Ala Asp Val 
    690                 695                 


<210>  19
<211>  1884
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Asp Ser His  Ile His Gly 
    1445                 1450                 1455             


Gln Arg  Asn Asn Ser Met Phe  Ser Lys Arg Pro Arg  Glu His Ile 
    1460                 1465                 1470             


Ser Val  Leu Thr Ser Gln Lys  Ser Ser Glu Tyr Pro  Ile Ser Gln 
    1475                 1480                 1485             


Asn Pro  Glu Gly Leu Ser Ala  Asp Lys Phe Glu Val  Ser Ala Asp 
    1490                 1495                 1500             


Ser Ser  Thr Ser Lys Asn Lys  Glu Pro Gly Val Glu  Arg Ser Ser 
    1505                 1510                 1515             


Pro Ser  Lys Cys Pro Ser Leu  Asp Asp Arg Trp Tyr  Met His Ser 
    1520                 1525                 1530             


Cys Ser  Gly Ser Leu Gln Asn  Arg Asn Tyr Pro Ser  Gln Glu Glu 
    1535                 1540                 1545             


Leu Ile  Lys Val Val Asp Val  Glu Glu Gln Gln Leu  Glu Glu Ser 
    1550                 1555                 1560             


Gly Pro  His Asp Leu Thr Glu  Thr Ser Tyr Leu Pro  Arg Gln Asp 
    1565                 1570                 1575             


Leu Glu  Gly Thr Pro Tyr Leu  Glu Ser Gly Ile Ser  Leu Phe Ser 
    1580                 1585                 1590             


Asp Asp  Pro Glu Ser Asp Pro  Ser Glu Asp Arg Ala  Pro Glu Ser 
    1595                 1600                 1605             


Ala Arg  Val Gly Asn Ile Pro  Ser Ser Thr Ser Ala  Leu Lys Val 
    1610                 1615                 1620             


Pro Gln  Leu Lys Val Ala Glu  Ser Ala Gln Ser Pro  Ala Ala Ala 
    1625                 1630                 1635             


His Thr  Thr Asp Thr Ala Gly  Tyr Asn Ala Met Glu  Glu Ser Val 
    1640                 1645                 1650             


Ser Arg  Glu Lys Pro Glu Leu  Thr Ala Ser Thr Glu  Arg Val Asn 
    1655                 1660                 1665             


Lys Arg  Met Ser Met Val Val  Ser Gly Leu Thr Pro  Glu Glu Phe 
    1670                 1675                 1680             


Met Leu  Val Tyr Lys Phe Ala  Arg Lys His His Ile  Thr Leu Thr 
    1685                 1690                 1695             


Asn Leu  Ile Thr Glu Glu Thr  Thr His Val Val Met  Lys Thr Asp 
    1700                 1705                 1710             


Ala Glu  Phe Val Cys Glu Arg  Thr Leu Lys Tyr Phe  Leu Gly Ile 
    1715                 1720                 1725             


Ala Gly  Gly Lys Trp Val Val  Ser Tyr Phe Trp Val  Thr Gln Ser 
    1730                 1735                 1740             


Ile Lys  Glu Arg Lys Met Leu  Asn Glu His Asp Phe  Glu Val Arg 
    1745                 1750                 1755             


Gly Asp  Val Val Asn Gly Arg  Asn His Gln Gly Pro  Lys Arg Ala 
    1760                 1765                 1770             


Arg Glu  Ser Gln Asp Arg Lys  Ile Phe Arg Gly Leu  Glu Ile Cys 
    1775                 1780                 1785             


Cys Tyr  Gly Pro Phe Thr Asn  Met Pro Thr Asp Gln  Leu Glu Trp 
    1790                 1795                 1800             


Met Val  Gln Leu Cys Gly Ala  Ser Val Val Lys Glu  Leu Ser Ser 
    1805                 1810                 1815             


Phe Thr  Leu Gly Thr Gly Val  His Pro Ile Val Val  Val Gln Pro 
    1820                 1825                 1830             


Asp Ala  Trp Thr Glu Asp Asn  Gly Phe His Ala Ile  Gly Gln Met 
    1835                 1840                 1845             


Cys Glu  Ala Pro Val Val Thr  Arg Glu Trp Val Leu  Asp Ser Val 
    1850                 1855                 1860             


Ala Leu  Tyr Gln Cys Gln Glu  Leu Asp Thr Tyr Leu  Ile Pro Gln 
    1865                 1870                 1875             


Ile Pro  His Ser His Tyr 
    1880                 


<210>  20
<211>  1816
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu 
1               5                   10                  15      


Cys Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe 
            20                  25                  30          


Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu 
        35                  40                  45              


Asp Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu 
    50                  55                  60                  


Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser 
65                  70                  75                  80  


Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu 
                85                  90                  95      


Asn Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu 
            100                 105                 110         


Gly Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys 
        115                 120                 125             


Thr Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val 
    130                 135                 140                 


Asn Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile 
145                 150                 155                 160 


Thr Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys 
                165                 170                 175     


Ala Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His 
            180                 185                 190         


Gln Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu 
        195                 200                 205             


Arg His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val 
    210                 215                 220                 


Glu Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn 
225                 230                 235                 240 


Ser Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu 
                245                 250                 255     


Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn 
            260                 265                 270         


Arg Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser 
        275                 280                 285             


Thr Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys 
    290                 295                 300                 


Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr 
305                 310                 315                 320 


Glu Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn 
                325                 330                 335     


Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His 
            340                 345                 350         


Asp Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val 
        355                 360                 365             


Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu 
    370                 375                 380                 


Leu Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val 
385                 390                 395                 400 


His Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys 
                405                 410                 415     


Thr Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu 
            420                 425                 430         


Asn Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu 
        435                 440                 445             


Arg Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly 
    450                 455                 460                 


Leu His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys 
465                 470                 475                 480 


Thr Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly 
                485                 490                 495     


Gln Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly 
            500                 505                 510         


Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu 
        515                 520                 525             


Lys Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile 
    530                 535                 540                 


Ser Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys 
545                 550                 555                 560 


Lys Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu 
                565                 570                 575     


Glu Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu 
            580                 585                 590         


Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr 
        595                 600                 605             


Asn Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly 
    610                 615                 620                 


Lys Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln 
625                 630                 635                 640 


Thr Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr 
                645                 650                 655     


Asn Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys 
            660                 665                 670         


Glu Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu 
        675                 680                 685             


Glu Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met 
    690                 695                 700                 


Leu Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser 
705                 710                 715                 720 


Ser Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile 
                725                 730                 735     


Ser Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn 
            740                 745                 750         


Lys Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile 
        755                 760                 765             


His Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr 
    770                 775                 780                 


Pro Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met 
785                 790                 795                 800 


Glu Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val 
                805                 810                 815     


Ser Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu 
            820                 825                 830         


Glu Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln 
        835                 840                 845             


Ser Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly 
    850                 855                 860                 


Lys Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala 
865                 870                 875                 880 


Gly Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys 
                885                 890                 895     


Cys Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg 
            900                 905                 910         


Gly Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln 
        915                 920                 925             


Asn Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys 
    930                 935                 940                 


Thr Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser 
945                 950                 955                 960 


Met Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val 
                965                 970                 975     


Ser Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala 
            980                 985                 990         


Ser Ser Ser Asn Ile Asn Glu Val  Gly Ser Ser Thr Asn  Glu Val Gly 
        995                 1000                 1005             


Ser Ser  Ile Asn Glu Ile Gly  Ser Ser Asp Glu Asn  Ile Gln Ala 
    1010                 1015                 1020             


Glu Leu  Gly Arg Asn Arg Gly  Pro Lys Leu Asn Ala  Met Leu Arg 
    1025                 1030                 1035             


Leu Gly  Val Leu Gln Pro Glu  Val Tyr Lys Gln Ser  Leu Pro Gly 
    1040                 1045                 1050             


Ser Asn  Cys Lys His Pro Glu  Ile Lys Lys Gln Glu  Tyr Glu Glu 
    1055                 1060                 1065             


Val Val  Gln Thr Val Asn Thr  Asp Phe Ser Pro Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Asp Asn  Leu Glu Gln Pro Met  Gly Ser Ser His Ala  Ser Gln Val 
    1085                 1090                 1095             


Cys Ser  Glu Thr Pro Asp Asp  Leu Leu Asp Asp Gly  Glu Ile Lys 
    1100                 1105                 1110             


Glu Asp  Thr Ser Phe Ala Glu  Asn Asp Ile Lys Glu  Ser Ser Ala 
    1115                 1120                 1125             


Val Phe  Ser Lys Ser Val Gln  Lys Gly Glu Leu Ser  Arg Ser Pro 
    1130                 1135                 1140             


Ser Pro  Phe Thr His Thr His  Leu Ala Gln Gly Tyr  Arg Arg Gly 
    1145                 1150                 1155             


Ala Lys  Lys Leu Glu Ser Ser  Glu Glu Asn Leu Ser  Ser Glu Asp 
    1160                 1165                 1170             


Glu Glu  Leu Pro Cys Phe Gln  His Leu Leu Phe Gly  Lys Val Asn 
    1175                 1180                 1185             


Asn Ile  Pro Ser Gln Ser Thr  Arg His Ser Thr Val  Ala Thr Glu 
    1190                 1195                 1200             


Cys Leu  Ser Lys Asn Thr Glu  Glu Asn Leu Leu Ser  Leu Lys Asn 
    1205                 1210                 1215             


Ser Leu  Asn Asp Cys Ser Asn  Gln Val Ile Leu Ala  Lys Ala Ser 
    1220                 1225                 1230             


Gln Glu  His His Leu Ser Glu  Glu Thr Lys Cys Ser  Ala Ser Leu 
    1235                 1240                 1245             


Phe Ser  Ser Gln Cys Ser Glu  Leu Glu Asp Leu Thr  Ala Asn Thr 
    1250                 1255                 1260             


Asn Thr  Gln Asp Pro Phe Leu  Ile Gly Ser Ser Lys  Gln Met Arg 
    1265                 1270                 1275             


His Gln  Ser Glu Ser Gln Gly  Val Gly Leu Ser Asp  Lys Glu Leu 
    1280                 1285                 1290             


Val Ser  Asp Asp Glu Glu Arg  Gly Thr Gly Leu Glu  Glu Asn Asn 
    1295                 1300                 1305             


Gln Glu  Glu Gln Ser Met Asp  Ser Asn Leu Gly Glu  Ala Ala Ser 
    1310                 1315                 1320             


Gly Cys  Glu Ser Glu Thr Ser  Val Ser Glu Asp Cys  Ser Gly Leu 
    1325                 1330                 1335             


Ser Ser  Gln Ser Asp Ile Leu  Thr Thr Gln Gln Arg  Asp Thr Met 
    1340                 1345                 1350             


Gln His  Asn Leu Ile Lys Leu  Gln Gln Glu Met Ala  Glu Leu Glu 
    1355                 1360                 1365             


Ala Val  Leu Glu Gln His Gly  Ser Gln Pro Ser Asn  Ser Tyr Pro 
    1370                 1375                 1380             


Ser Ile  Ile Ser Asp Ser Ser  Ala Leu Glu Asp Leu  Arg Asn Pro 
    1385                 1390                 1395             


Glu Gln  Ser Thr Ser Glu Lys  Ala Val Leu Thr Ser  Gln Lys Ser 
    1400                 1405                 1410             


Ser Glu  Tyr Pro Ile Ser Gln  Asn Pro Glu Gly Leu  Ser Ala Asp 
    1415                 1420                 1425             


Lys Phe  Glu Val Ser Ala Asp  Ser Ser Thr Ser Lys  Asn Lys Glu 
    1430                 1435                 1440             


Pro Gly  Val Glu Arg Ser Ser  Pro Ser Lys Cys Pro  Ser Leu Asp 
    1445                 1450                 1455             


Asp Arg  Trp Tyr Met His Ser  Cys Ser Gly Ser Leu  Gln Asn Arg 
    1460                 1465                 1470             


Asn Tyr  Pro Ser Gln Glu Glu  Leu Ile Lys Val Val  Asp Val Glu 
    1475                 1480                 1485             


Glu Gln  Gln Leu Glu Glu Ser  Gly Pro His Asp Leu  Thr Glu Thr 
    1490                 1495                 1500             


Ser Tyr  Leu Pro Arg Gln Asp  Leu Glu Gly Thr Pro  Tyr Leu Glu 
    1505                 1510                 1515             


Ser Gly  Ile Ser Leu Phe Ser  Asp Asp Pro Glu Ser  Asp Pro Ser 
    1520                 1525                 1530             


Glu Asp  Arg Ala Pro Glu Ser  Ala Arg Val Gly Asn  Ile Pro Ser 
    1535                 1540                 1545             


Ser Thr  Ser Ala Leu Lys Val  Pro Gln Leu Lys Val  Ala Glu Ser 
    1550                 1555                 1560             


Ala Gln  Ser Pro Ala Ala Ala  His Thr Thr Asp Thr  Ala Gly Tyr 
    1565                 1570                 1575             


Asn Ala  Met Glu Glu Ser Val  Ser Arg Glu Lys Pro  Glu Leu Thr 
    1580                 1585                 1590             


Ala Ser  Thr Glu Arg Val Asn  Lys Arg Met Ser Met  Val Val Ser 
    1595                 1600                 1605             


Gly Leu  Thr Pro Glu Glu Phe  Met Leu Val Tyr Lys  Phe Ala Arg 
    1610                 1615                 1620             


Lys His  His Ile Thr Leu Thr  Asn Leu Ile Thr Glu  Glu Thr Thr 
    1625                 1630                 1635             


His Val  Val Met Lys Thr Asp  Ala Glu Phe Val Cys  Glu Arg Thr 
    1640                 1645                 1650             


Leu Lys  Tyr Phe Leu Gly Ile  Ala Gly Gly Lys Trp  Val Val Ser 
    1655                 1660                 1665             


Tyr Phe  Trp Val Thr Gln Ser  Ile Lys Glu Arg Lys  Met Leu Asn 
    1670                 1675                 1680             


Glu His  Asp Phe Glu Val Arg  Gly Asp Val Val Asn  Gly Arg Asn 
    1685                 1690                 1695             


His Gln  Gly Pro Lys Arg Ala  Arg Glu Ser Gln Asp  Arg Lys Ile 
    1700                 1705                 1710             


Phe Arg  Gly Leu Glu Ile Cys  Cys Tyr Gly Pro Phe  Thr Asn Met 
    1715                 1720                 1725             


Pro Thr  Asp Gln Leu Glu Trp  Met Val Gln Leu Cys  Gly Ala Ser 
    1730                 1735                 1740             


Val Val  Lys Glu Leu Ser Ser  Phe Thr Leu Gly Thr  Gly Val His 
    1745                 1750                 1755             


Pro Ile  Val Val Val Gln Pro  Asp Ala Trp Thr Glu  Asp Asn Gly 
    1760                 1765                 1770             


Phe His  Ala Ile Gly Gln Met  Cys Glu Ala Pro Val  Val Thr Arg 
    1775                 1780                 1785             


Glu Trp  Val Leu Asp Ser Val  Ala Leu Tyr Gln Cys  Gln Glu Leu 
    1790                 1795                 1800             


Asp Thr  Tyr Leu Ile Pro Gln  Ile Pro His Ser His  Tyr 
    1805                 1810                 1815     


<210>  21
<211>  3418
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp 
    210                 215                 220                 


Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr 
                645                 650                 655     


Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr 
        755                 760                 765             


Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr 
            900                 905                 910         


Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Thr Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Thr  Ser Leu Ala Cys Val  Glu Ile Val Asn Thr  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Thr Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Thr Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Thr Pro  Ser Gln Lys Ala Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu Ser  Thr Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Thr 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Thr Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Thr  Ile Leu Lys Thr Thr  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Thr  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Thr Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Thr  Lys Leu Asn Val Ser  Thr Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Thr Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Thr Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Thr Thr Gly Thr Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Thr  Glu Asn Tyr Lys Arg  Asn Thr Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Thr  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Thr Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Thr Asp  Leu Leu Phe Thr Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Thr Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Thr Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Thr Ser Asn  Lys Glu Gln Leu Thr  Ala Thr Lys 
    1400                 1405                 1410             


Thr Glu  Gln Asn Ile Lys Asp  Phe Glu Thr Ser Asp  Thr Phe Phe 
    1415                 1420                 1425             


Gln Thr  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Thr Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Thr Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Thr  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Thr  Leu Leu Gly Phe His  Thr Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Thr Ser Glu  Ile Thr Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Thr Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Thr Ile Glu Ile  Thr Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Thr Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Thr Glu  Asn Leu Lys Thr Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Thr Ala Lys Ser  Pro Ala Thr 
    1640                 1645                 1650             


Cys Tyr  Thr Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Thr Ser Cys  Ser Arg Lys Thr Ser  Val Ser Gln 
    1670                 1675                 1680             


Thr Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Thr Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Thr Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Thr Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Thr  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Thr 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Thr  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Thr Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Thr Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Thr Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Thr  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Thr Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Thr Cys  Gly Ile Phe Ser Thr  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Thr Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Thr Arg Glu 
    2015                 2020                 2025             


Glu Asn  Thr Ala Ile Arg Thr  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Thr  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Thr 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Thr Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Thr  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Thr Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Thr Glu Thr Phe  Ser Asp Val Pro Val  Lys Thr Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Thr Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Thr  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Thr Asp Ser Lys Leu  Pro Ser His Ala Thr  His Ser Leu 
    2240                 2245                 2250             


Phe Thr  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Thr  Pro Asp Gly 
    2300                 2305                 2310             


Thr Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Thr Cys Val Pro Phe  Arg Thr Thr Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Thr  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Thr Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Thr 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Thr Thr Gly  Arg Pro Thr 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Thr Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Ala Ala Val Thr Phe  Thr Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Thr Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Thr  Ser Thr Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Thr Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Thr Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Thr  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Thr Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Thr Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Thr Ala Ala Lys Thr  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Thr 
    2690                 2695                 2700             


Ser Ser  Asn Lys Thr Ser Ser  Ala Asp Thr Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Thr Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Thr Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Thr Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Thr Arg Pro  Ala Arg Trp Tyr Thr  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Thr Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Thr Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Thr  Thr Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Thr Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Thr Thr Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Thr Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Thr Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Thr  Lys Lys Thr 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Thr  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Thr Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Thr Phe Asn  Lys Met Lys Asn Thr  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Thr Pro Thr  Lys Asp Cys 
    3185                 3190                 3195             


Thr Ser  Gly Pro Tyr Thr Ala  Gln Ile Ile Pro Gly  Thr Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Thr Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Thr Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Thr 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Thr Lys Tyr Glu Thr  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Thr Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Thr Gln  Ala Leu Leu Ser Gly  Ser Thr Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Thr Arg  Thr Ala Pro Thr Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Thr Thr Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Thr Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Thr Ile Thr Thr Lys  Lys Tyr Ile 
    3410                 3415             


<210>  22
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  23
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Val Ala Glu Arg 
65                  70                  75                  80  


Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala Arg 
                85                  90                  95      


Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser Ala 
            100                 105                 110         


Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala Thr 
        115                 120                 125             


Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala Arg 
    130                 135                 140                 


Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala Asp 
145                 150                 155                 160 


Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln Val 
                165                 170                 175     


Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly Gly 
            180                 185                 190         


Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys Gly 
        195                 200                 205             


Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu Pro 
    210                 215                 220                 


Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp Ala 
225                 230                 235                 240 


Lys Asp 
        


<210>  24
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Ile Val Ser Glu Glu Arg Lys Arg Gly Asn Gln Asn Leu Gln 
            260                 265                 270         


Asn Leu Arg Leu Ser Leu Ser Ser 
        275                 280 


<210>  25
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ser Arg Ser 
65                  70                  75                  80  


Val Ala Arg Leu Glu Cys Asn Ser Val Ile Leu Val Tyr Cys Thr Leu 
                85                  90                  95      


Arg Leu Ser Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Val 
            100                 105                 110         


Gly Thr Thr Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly 
        115                 120                 125             


Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr 
    130                 135                 140                 


Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr 
145                 150                 155                 160 


Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala 
                165                 170                 175     


Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr 
            180                 185                 190         


Ala Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala 
        195                 200                 205             


Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser 
    210                 215                 220                 


Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser 
225                 230                 235                 240 


Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu 
                245                 250                 255     


Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala 
            260                 265                 270         


Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile 
        275                 280                 285             


Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg 
    290                 295                 300                 


Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys 
305                 310                 315                 320 


Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly 
                325                 330                 335     


Asp Ala Lys Asp 
            340 


<210>  26
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Gly Lys Thr Phe Arg Phe Glu Met Gln Arg Asp Leu Val Ser 
1               5                   10                  15      


Phe Pro Leu Ser Pro Ala Val Arg Val Lys Leu Val Ser Ala Gly Phe 
            20                  25                  30          


Gln Thr Ala Glu Glu Leu Leu Glu Val Lys Pro Ser Glu Leu Ser Lys 
        35                  40                  45              


Glu Val Gly Ile Ser Lys Ala Glu Ala Leu Glu Thr Leu Gln Ile Ile 
    50                  55                  60                  


Arg Arg Glu Cys Leu Thr Asn Lys Pro Arg Tyr Ala Gly Thr Ser Glu 
65                  70                  75                  80  


Ser His Lys Lys Cys Thr Ala Leu Glu Leu Leu Glu Gln Glu His Thr 
                85                  90                  95      


Gln Gly Phe Ile Ile Thr Phe Cys Ser Ala Leu Asp Asp Ile Leu Gly 
            100                 105                 110         


Gly Gly Val Pro Leu Met Lys Thr Thr Glu Ile Cys Gly Ala Pro Gly 
        115                 120                 125             


Val Gly Lys Thr Gln Leu Cys Met Gln Leu Ala Val Asp Val Gln Ile 
    130                 135                 140                 


Pro Glu Cys Phe Gly Gly Val Ala Gly Glu Ala Val Phe Ile Asp Thr 
145                 150                 155                 160 


Glu Gly Ser Phe Met Val Asp Arg Val Val Asp Leu Ala Thr Ala Cys 
                165                 170                 175     


Ile Gln His Leu Gln Leu Ile Ala Glu Lys His Lys Gly Glu Glu His 
            180                 185                 190         


Arg Lys Ala Leu Glu Asp Phe Thr Leu Asp Asn Ile Leu Ser His Ile 
        195                 200                 205             


Tyr Tyr Phe Arg Cys Arg Asp Tyr Thr Glu Leu Leu Ala Gln Val Tyr 
    210                 215                 220                 


Leu Leu Pro Asp Phe Leu Ser Glu His Ser Lys Val Arg Leu Val Ile 
225                 230                 235                 240 


Val Asp Gly Ile Ala Phe Pro Phe Arg His Asp Leu Asp Asp Leu Ser 
                245                 250                 255     


Leu Arg Thr Arg Leu Leu Asn Gly Leu Ala Gln Gln Met Ile Ser Leu 
            260                 265                 270         


Ala Asn Asn His Arg Leu Ala Val Ile Leu Thr Asn Gln Met Thr Thr 
        275                 280                 285             


Lys Ile Asp Arg Asn Gln Ala Leu Leu Val Pro Ala Leu Gly Glu Ser 
    290                 295                 300                 


Trp Gly His Ala Ala Thr Ile Arg Leu Ile Phe His Trp Asp Arg Lys 
305                 310                 315                 320 


Gln Arg Leu Ala Thr Leu Tyr Lys Ser Pro Ser Gln Lys Glu Cys Thr 
                325                 330                 335     


Val Leu Phe Gln Ile Lys Pro Gln Gly Phe Arg Asp Thr Val Val Thr 
            340                 345                 350         


Ser Ala Cys Ser Leu Gln Thr Glu Gly Ser Leu Ser Thr Arg Lys Arg 
        355                 360                 365             


Ser Arg Asp Pro Glu Glu Glu Leu 
    370                 375     


<210>  27
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Arg Gly Lys Thr Phe Arg Phe Glu Met Gln Arg Asp Leu Val Ser 
1               5                   10                  15      


Phe Pro Leu Ser Pro Ala Val Arg Val Lys Leu Val Ser Ala Gly Phe 
            20                  25                  30          


Gln Thr Ala Glu Glu Leu Leu Glu Val Lys Pro Ser Glu Leu Ser Lys 
        35                  40                  45              


Glu Val Gly Ile Ser Lys Ala Glu Ala Leu Glu Thr Leu Gln Ile Ile 
    50                  55                  60                  


Arg Arg Glu Cys Leu Thr Asn Lys Pro Arg Tyr Ala Gly Thr Ser Glu 
65                  70                  75                  80  


Ser His Lys Lys Cys Thr Ala Leu Glu Leu Leu Glu Gln Glu His Thr 
                85                  90                  95      


Gln Gly Phe Ile Ile Thr Phe Cys Ser Ala Leu Asp Asp Ile Leu Gly 
            100                 105                 110         


Gly Gly Val Pro Leu Met Lys Thr Thr Glu Ile Cys Gly Ala Pro Gly 
        115                 120                 125             


Val Gly Lys Thr Gln Leu Trp 
    130                 135 


<210>  28
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Ala Leu Val Ala Leu Arg Arg Val Leu Leu Ala Gln Phe Ser Ala Phe 
    50                  55                  60                  


Pro Val Asn Gly Ala Asp Leu Tyr Glu Glu Leu Lys Thr Ser Thr Ala 
65                  70                  75                  80  


Ile Leu Ser Thr Gly Ile Gly Ser Leu Asp Lys Leu Leu Asp Ala Gly 
                85                  90                  95      


Leu Tyr Thr Gly Glu Val Thr Glu Ile Val Gly Gly Pro Gly Ser Gly 
            100                 105                 110         


Lys Thr Gln Val Cys Leu Cys Met Ala Ala Asn Val Ala His Gly Leu 
        115                 120                 125             


Gln Gln Asn Val Leu Tyr Val Asp Ser Asn Gly Gly Leu Thr Ala Ser 
    130                 135                 140                 


Arg Leu Leu Gln Leu Leu Gln Ala Lys Thr Gln Asp Glu Glu Glu Gln 
145                 150                 155                 160 


Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala Phe Asp Ile Phe 
                165                 170                 175     


Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr Val Ala Gln Gln 
            180                 185                 190         


Val Thr Gly Ser Ser Gly Thr Val Lys Val Val Val Val Asp Ser Val 
        195                 200                 205             


Thr Ala Val Val Ser Pro Leu Leu Gly Gly Gln Gln Arg Glu Gly Leu 
    210                 215                 220                 


Ala Leu Met Met Gln Leu Ala Arg Glu Leu Lys Thr Leu Ala Arg Asp 
225                 230                 235                 240 


Leu Gly Met Ala Val Val Val Thr Asn His Ile Thr Arg Asp Arg Asp 
                245                 250                 255     


Ser Gly Arg Leu Lys Pro Ala Leu Gly Arg Ser Trp Ser Phe Val Pro 
            260                 265                 270         


Ser Thr Arg Ile Leu Leu Asp Thr Ile Glu Gly Ala Gly Ala Ser Gly 
        275                 280                 285             


Gly Arg Arg Met Ala Cys Leu Ala Lys Ser Ser Arg Gln Pro Thr Gly 
    290                 295                 300                 


Phe Gln Glu Met Val Asp Ile Gly Thr Trp Gly Thr Ser Glu Gln Ser 
305                 310                 315                 320 


Ala Thr Leu Gln Gly Asp Gln Thr 
                325             


<210>  29
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Ser 
    


<210>  30
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala Phe Asp Ile Phe 
    50                  55                  60                  


Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr Val Ala Gln Gln 
65                  70                  75                  80  


Val Thr Gly Ser Ser Gly Thr Val Lys Val Val Val Val Asp Ser Val 
                85                  90                  95      


Thr Ala Val Val Ser Pro Leu Leu Gly Gly Gln Gln Arg Glu Gly Leu 
            100                 105                 110         


Ala Leu Met Met Gln Leu Ala Arg Glu Leu Lys Thr Leu Ala Arg Asp 
        115                 120                 125             


Leu Gly Met Ala Val Val Val Thr Asn His Ile Thr Arg Asp Arg Asp 
    130                 135                 140                 


Ser Gly Arg Leu Lys Pro Ala Leu Gly Arg Ser Trp Ser Phe Val Pro 
145                 150                 155                 160 


Ser Thr Arg Ile Leu Leu Asp Thr Ile Glu Gly Ala Gly Ala Ser Gly 
                165                 170                 175     


Gly Arg Arg Met Ala Cys Leu Ala Lys Ser Ser Arg Gln Pro Thr Gly 
            180                 185                 190         


Phe Gln Glu Met Val Asp Ile Gly Thr Trp Gly Thr Ser Glu Gln Ser 
        195                 200                 205             


Ala Thr Leu Gln Gly Asp Gln Thr 
    210                 215     


<210>  31
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Ala Leu Val Ala Leu Arg Arg Val Leu Leu Ala Gln Phe Ser Ala Phe 
    50                  55                  60                  


Pro Val Asn Gly Ala Asp Leu Tyr Glu Glu Leu Lys Thr Ser Thr Ala 
65                  70                  75                  80  


Ile Leu Ser Thr Gly Ile Gly Ser Leu Asp Lys Leu Leu Asp Ala Gly 
                85                  90                  95      


Leu Tyr Thr Gly Glu Val Thr Glu Ile Val Gly Gly Pro Gly Ser Gly 
            100                 105                 110         


Lys Thr Gln Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala Phe 
        115                 120                 125             


Asp Ile Phe Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr Val 
    130                 135                 140                 


Ala Gln Gln Val Thr Gly Ser Ser Gly Thr Val Lys Val Val Val Val 
145                 150                 155                 160 


Asp Ser Val Thr Ala Val Val Ser Pro Leu Leu Gly Gly Gln Gln Arg 
                165                 170                 175     


Glu Gly Leu Ala Leu Met Met Gln Leu Ala Arg Glu Leu Lys Thr Leu 
            180                 185                 190         


Ala Arg Asp Leu Gly Met Ala Val Val Val Thr Asn His Ile Thr Arg 
        195                 200                 205             


Asp Arg Asp Ser Gly Arg Leu Lys Pro Ala Leu Gly Arg Ser Trp Ser 
    210                 215                 220                 


Phe Val Pro Ser Thr Arg Ile Leu Leu Asp Thr Ile Glu Gly Ala Gly 
225                 230                 235                 240 


Ala Ser Gly Gly Arg Arg Met Ala Cys Leu Ala Lys Ser Ser Arg Gln 
                245                 250                 255     


Pro Thr Gly Phe Gln Glu Met Val Asp Ile Gly Thr Trp Gly Thr Ser 
            260                 265                 270         


Glu Gln Ser Ala Thr Leu Gln Gly Asp Gln Thr 
        275                 280             


<210>  32
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Ala Leu Val Ala Leu Arg Arg Val Leu Leu Ala Gln Phe Ser Ala Phe 
    50                  55                  60                  


Pro Val Asn Gly Ala Asp Leu Tyr Glu Glu Leu Lys Thr Ser Thr Ala 
65                  70                  75                  80  


Ile Leu Ser Thr Gly Ile Gly Arg Gln Lys Leu Ser Gly Gly Ser Arg 
                85                  90                  95      


Trp Cys Met His Leu Val Thr Glu Ile Val Gly Gly Pro Gly Ser Gly 
            100                 105                 110         


Lys Thr Gln Val Cys Leu Cys Met Ala Ala Asn Val Ala His Gly Leu 
        115                 120                 125             


Gln Gln Asn Val Leu Tyr Val Asp Ser Asn Gly Gly Leu Thr Ala Ser 
    130                 135                 140                 


Arg Leu Leu Gln Leu Leu Gln Ala Lys Thr Gln Asp Glu Glu Glu Gln 
145                 150                 155                 160 


Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala Phe Asp Ile Phe 
                165                 170                 175     


Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr Val Ala Gln Gln 
            180                 185                 190         


Val Thr Gly Ser Ser Gly Thr Val Lys Val Val Val Val Asp Ser Val 
        195                 200                 205             


Thr Ala Val Val Ser Pro Leu Leu Gly Gly Gln Gln Arg Glu Gly Leu 
    210                 215                 220                 


Ala Leu Met Met Gln Leu Ala Arg Glu Leu Lys Thr Leu Ala Arg Asp 
225                 230                 235                 240 


Leu Gly Met Ala Val Val Val Thr Asn His Ile Thr Arg Asp Arg Asp 
                245                 250                 255     


Ser Gly Arg Leu Lys Pro Ala Leu Gly Arg Ser Trp Ser Phe Val Pro 
            260                 265                 270         


Ser Thr Arg Ile Leu Leu Asp Thr Ile Glu Gly Ala Gly Ala Ser Gly 
        275                 280                 285             


Gly Arg Arg Met Ala Cys Leu Ala Lys Ser Ser Arg Gln Pro Thr Gly 
    290                 295                 300                 


Phe Gln Glu Met Val Asp Ile Gly Thr Trp Gly Thr Ser Glu Gln Ser 
305                 310                 315                 320 


Ala Thr Leu Gln Gly Asp Gln Thr 
                325             


<210>  33
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Ala Leu Val Ala Leu Arg Arg Val Leu Leu Ala Gln Phe Ser Ala Phe 
    50                  55                  60                  


Pro Val Asn Gly Ala Asp Leu Tyr Glu Glu Leu Lys Thr Ser Thr Ala 
65                  70                  75                  80  


Ile Leu Ser Thr Gly Ile Gly Arg His Gly Gly Arg Thr Gln Val Gly 
                85                  90                  95      


Thr Trp Glu Asp Cys Ser Cys Leu Arg Ser Pro Gln Gly Asp Arg Gly 
            100                 105                 110         


Val Gly Ser Gly Met Leu 
        115             


<210>  34
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Ala Leu Val Ala Leu Arg Arg Val Leu Leu Ala Gln Phe Ser Ala Phe 
    50                  55                  60                  


Pro Val Asn Gly Ala Asp Leu Tyr Glu Glu Leu Lys Thr Ser Thr Ala 
65                  70                  75                  80  


Ile Leu Ser Thr Gly Ile Gly Ser Leu Asp Lys Leu Leu Asp Ala Gly 
                85                  90                  95      


Leu Tyr Thr Gly Glu Val Thr Glu Ile Val Gly Gly Pro Gly Ser Gly 
            100                 105                 110         


Lys Thr Gln Val Cys Leu Cys Met Ala Ala Asn Val Ala His Gly Leu 
        115                 120                 125             


Gln Gln Asn Val Leu Tyr Val Asp Ser Asn Gly Gly Leu Thr Ala Ser 
    130                 135                 140                 


Arg Leu Leu Gln Leu Leu Gln Ala Lys Thr Gln Asp Glu Glu Glu Gln 
145                 150                 155                 160 


Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala Phe Asp Ile Phe 
                165                 170                 175     


Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr Val Ala Gln Gln 
            180                 185                 190         


Asp Gly Ile Pro Glu His Leu Asn His Ile Pro His Cys Leu His Val 
        195                 200                 205             


His Leu Pro Cys 
    210         


<210>  35
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Thr Trp Arg Ala His Ser Ser Gly Asn Leu Gly Gly Leu Gln Leu Pro 
    50                  55                  60                  


Gln Val Pro Ala Gly Arg Ser Trp Ser Gly Val Arg Asn Ala Leu Lys 
65                  70                  75                  80  


Lys Ala Gly Leu Gly His Gly Gly Thr Asp Gly Leu Ser Leu Asn Ala 
                85                  90                  95      


Phe Asp Glu Arg Gly Thr Ala Val Ser Thr Ser Arg Leu Asp Lys Leu 
            100                 105                 110         


Leu Asp Ala Gly Leu Tyr Thr Gly Glu Val Thr Glu Ile Val Gly Gly 
        115                 120                 125             


Pro Gly Ser Gly Lys Thr Gln Val Cys Leu Cys Met Ala Ala Asn Val 
    130                 135                 140                 


Ala His Gly Leu Gln Gln Asn Val Leu Tyr Val Asp Ser Asn Gly Gly 
145                 150                 155                 160 


Leu Thr Ala Ser Arg Leu Leu Gln Leu Leu Gln Ala Lys Thr Gln Asp 
                165                 170                 175     


Glu Glu Glu Gln Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala 
            180                 185                 190         


Phe Asp Ile Phe Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr 
        195                 200                 205             


Val Ala Gln Gln Val Thr Gly Ser Ser Gly Thr Val Lys Val Val Val 
    210                 215                 220                 


Val Asp Ser Val Thr Ala Val Val Ser Pro Leu Leu Gly Gly Gln Gln 
225                 230                 235                 240 


Arg Glu Gly Leu Ala Leu Met Met Gln Leu Ala Arg Glu Leu Lys Thr 
                245                 250                 255     


Leu Ala Arg Asp Leu Gly Met Ala Val Val Val Thr Asn His Ile Thr 
            260                 265                 270         


Arg Asp Arg Asp Ser Gly Arg Leu Lys Pro Ala Leu Gly Arg Ser Trp 
        275                 280                 285             


Ser Phe Val Pro Ser Thr Arg Ile Leu Leu Asp Thr Ile Glu Gly Ala 
    290                 295                 300                 


Gly Ala Ser Gly Gly Arg Arg Met Ala Cys Leu Ala Lys Ser Ser Arg 
305                 310                 315                 320 


Gln Pro Thr Gly Phe Gln Glu Met Val Asp Ile Gly Thr Trp Gly Thr 
                325                 330                 335     


Ser Glu Gln Ser Ala Thr Leu Gln Gly Asp Gln Thr 
            340                 345             


<210>  36
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Cys Ser Ala Phe His Arg Ala Glu Ser Gly Thr Glu Leu Leu Ala 
1               5                   10                  15      


Arg Leu Glu Gly Arg Ser Ser Leu Lys Glu Ile Glu Pro Asn Leu Phe 
            20                  25                  30          


Ala Asp Glu Asp Ser Pro Val His Gly Asp Ile Leu Glu Phe His Gly 
        35                  40                  45              


Pro Glu Gly Thr Gly Lys Thr Glu Met Leu Tyr His Leu Thr Ala Arg 
    50                  55                  60                  


Cys Ile Leu Pro Lys Ser Glu Gly Gly Leu Glu Val Glu Val Leu Phe 
65                  70                  75                  80  


Ile Asp Thr Asp Tyr His Phe Asp Met Leu Arg Leu Val Thr Ile Leu 
                85                  90                  95      


Glu His Arg Leu Ser Gln Ser Ser Glu Glu Ile Ile Lys Tyr Cys Leu 
            100                 105                 110         


Gly Arg Phe Phe Leu Val Tyr Cys Ser Ser Ser Thr His Leu Leu Leu 
        115                 120                 125             


Thr Leu Tyr Ser Leu Glu Ser Met Phe Cys Ser His Pro Ser Leu Cys 
    130                 135                 140                 


Leu Leu Ile Leu Asp Ser Leu Ser Ala Phe Tyr Trp Ile Asp Arg Val 
145                 150                 155                 160 


Asn Gly Gly Glu Ser Val Asn Leu Gln Glu Ser Thr Leu Arg Lys Cys 
                165                 170                 175     


Ser Gln Cys Leu Glu Lys Leu Val Asn Asp Tyr Arg Leu Val Leu Phe 
            180                 185                 190         


Ala Thr Thr Gln Thr Ile Met Gln Lys Ala Ser Ser Ser Ser Glu Glu 
        195                 200                 205             


Pro Ser His Ala Ser Arg Arg Leu Cys Asp Val Asp Ile Asp Tyr Arg 
    210                 215                 220                 


Pro Tyr Leu Cys Lys Ala Trp Gln Gln Leu Val Lys His Arg Met Phe 
225                 230                 235                 240 


Phe Ser Lys Gln Asp Asp Ser Gln Ser Ser Asn Gln Phe Ser Leu Val 
                245                 250                 255     


Ser Arg Cys Leu Lys Ser Asn Ser Leu Lys Lys His Phe Phe Ile Ile 
            260                 265                 270         


Gly Glu Ser Gly Val Glu Phe Cys 
        275                 280 


<210>  37
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 
    130                 135                 140                 


Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 
145                 150                 155                 160 


Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 
                165                 170                 175     


His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 
            180                 185                 190         


Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 
        195                 200                 205             


Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 
    210                 215                 220                 


Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 
225                 230                 235                 240 


Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 
                245                 250                 255     


Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 
            260                 265                 270         


Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 
        275                 280                 285             


Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 
    290                 295                 300                 


Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 
305                 310                 315                 320 


Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 
                325                 330                 335     


Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 
            340                 345                 350         


Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Glu 
        355                 360                 365             


Thr Lys Lys Glu Leu Val Leu Glu Ser Asn Pro Lys Trp Glu Ala Leu 
    370                 375                 380                 


Thr Glu Val Leu Lys Glu Ile Glu Ala Glu Asn Lys Glu Ser Glu Ala 
385                 390                 395                 400 


Leu Gly Gly Pro Gly Gln Val Leu Ile Cys Ala Ser Asp Asp Arg Thr 
                405                 410                 415     


Cys Ser Gln Leu Arg Asp Tyr Ile Thr Leu Gly Ala Glu Ala Phe Leu 
            420                 425                 430         


Leu Arg Leu Tyr Arg Lys Thr Phe Glu Lys Asp Ser Lys Ala Glu Glu 
        435                 440                 445             


Val Trp Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys 
    450                 455                 460                 


Ser His Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Glu Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln 
                485                 490                 495     


Met Val Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu 
            500                 505                 510         


Gly Tyr Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu 
        515                 520                 525             


Ile Lys His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe 
    530                 535                 540                 


Gly Ile Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys 
545                 550                 555                 560 


Ser Asp Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg 
                565                 570                 575     


Tyr Val Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu 
            580                 585                 590         


Ile Tyr Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu 
        595                 600                 605             


Ile Tyr Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg 
    610                 615                 620                 


Lys Glu Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met 
625                 630                 635                 640 


Val Val Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu 
                645                 650                 655     


Val Arg Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala 
            660                 665                 670         


Gly Gly Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met 
        675                 680                 685             


Arg Glu Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile 
    690                 695                 700                 


Asp Ile Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro 
705                 710                 715                 720 


Glu Met Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu 
                725                 730                 735     


Asn Asn Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr 
            740                 745                 750         


Lys Arg Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser 
        755                 760                 765             


Leu Thr Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile 
    770                 775                 780                 


Ser Ser Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile 
785                 790                 795                 800 


Leu Trp Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu 
                805                 810                 815     


Lys Gln Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr 
            820                 825                 830         


Ala Asp Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro 
        835                 840                 845             


Gln Asp Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg 
    850                 855                 860                 


Ser Leu Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser 
865                 870                 875                 880 


Gln Asp Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln 
                885                 890                 895     


Leu Tyr Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly 
            900                 905                 910         


Lys Gly Lys Lys 
        915     


<210>  38
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 
    130                 135                 140                 


Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 
145                 150                 155                 160 


Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 
                165                 170                 175     


His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 
            180                 185                 190         


Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 
        195                 200                 205             


Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 
    210                 215                 220                 


Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 
225                 230                 235                 240 


Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 
                245                 250                 255     


Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 
            260                 265                 270         


Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 
        275                 280                 285             


Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 
    290                 295                 300                 


Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 
305                 310                 315                 320 


Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 
                325                 330                 335     


Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 
            340                 345                 350         


Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Gly 
        355                 360                 365             


Ile Leu Trp Gly 
    370         


<210>  39
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  40
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Phe Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr 
        595                 600                 605             


Thr Lys Asn Tyr Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu 
    610                 615                 620                 


Glu Asp Ile Phe Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser 
625                 630                 635                 640 


Thr Ser Ser Ser Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val 
                645                 650                 655     


Asp Phe Glu Ser Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr 
            660                 665                 670         


Ser Ser Leu Arg Arg Asn Arg Arg 
        675                 680 


<210>  41
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Asn Arg Asn Ile Ser His Gln Lys Gly Asp Asp Glu Asn Thr Phe 
1               5                   10                  15      


Lys Ile Leu Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp 
            20                  25                  30          


Ala Val Arg Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg 
        35                  40                  45              


Leu Ala Gln Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu 
    50                  55                  60                  


Phe His Glu Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu 
65                  70                  75                  80  


Leu Leu Arg Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile 
                85                  90                  95      


Leu Ser Asp Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val 
            100                 105                 110         


Asn Tyr Gln Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile 
        115                 120                 125             


His Gly Asn His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu 
    130                 135                 140                 


Asp Ile Leu Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met 
145                 150                 155                 160 


Ser Val Glu Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser 
                165                 170                 175     


Thr Lys Ile Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu 
            180                 185                 190         


Tyr Arg Met Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu 
        195                 200                 205             


Asp Glu Asn Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser 
    210                 215                 220                 


Lys His Gly Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe 
225                 230                 235                 240 


Ile Asp Leu Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro 
                245                 250                 255     


Thr Lys Asn Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser 
            260                 265                 270         


Val Val Thr Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly 
        275                 280                 285             


Leu Leu Arg Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu 
    290                 295                 300                 


His Thr Val Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His 
305                 310                 315                 320 


Pro Asp Ile Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln 
                325                 330                 335     


Ser Phe Cys Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu 
        355                 360                 365             


Arg Val Asp Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe 
    370                 375                 380                 


Ser Gln Lys Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His 
385                 390                 395                 400 


Phe Phe Arg His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn 
                405                 410                 415     


Phe Gly Lys Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val 
            420                 425                 430         


Glu Asp Leu Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln 
        435                 440                 445             


Leu Ser Leu Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe 
    450                 455                 460                 


Val Asp Lys Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln 
465                 470                 475                 480 


Leu Glu Lys Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu 
                485                 490                 495     


Glu Asp Lys Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln 
            500                 505                 510         


Lys Asn Thr Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg 
        515                 520                 525             


Ala Arg Ala Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser 
    530                 535                 540                 


Ala Asp Asp Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp 
545                 550                 555                 560 


Ser Asp Asp Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly 
                565                 570                 575     


Arg Gly Arg Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly 
            580                 585                 590         


Ser Gln Arg Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser 
        595                 600                 605             


Arg Asn Ser Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile 
    610                 615                 620                 


Asp Ala Phe Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr 
625                 630                 635                 640 


Lys Asn Tyr Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu 
                645                 650                 655     


Asp Ile Phe Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr 
            660                 665                 670         


Ser Ser Ser Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp 
        675                 680                 685             


Phe Glu Ser Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser 
    690                 695                 700                 


Ser Leu Arg Arg Asn Arg Arg 
705                 710     


<210>  42
<211>  3056
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  43
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Thr Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Cys Val Ser Asp Cys Ile Gly 
65                  70                  75                  80  


Thr Gly Cys Pro Val Cys Tyr Thr Pro Ala Trp Ile Gln Asp Leu Lys 
                85                  90                  95      


Ile Asn Arg Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg 
            100                 105                 110         


Asn Leu Leu His Asp Asn Glu Leu Ser Asp Leu Lys Glu Asp Lys Pro 
        115                 120                 125             


Arg Lys Ser Leu Phe Asn Asp Ala Gly Asn Lys Lys Asn Ser Ile Lys 
    130                 135                 140                 


Met Trp Phe Ser Pro Arg Ser Lys Lys Val Arg Tyr Val Val Ser Lys 
145                 150                 155                 160 


Ala Ser Val Gln Thr Gln Pro Ala Ile Lys Lys Asp Ala Ser Ala Gln 
                165                 170                 175     


Gln Asp Ser Tyr Glu Phe Val Ser Pro Ser Pro Pro Ala Asp Val Ser 
            180                 185                 190         


Glu Arg Ala Lys Lys Ala Ser Ala Arg Ser Gly Lys Lys Gln Lys Lys 
        195                 200                 205             


Lys Thr Leu Ala Glu Ile Asn Gln Lys Trp Asn Leu Glu Ala Glu Lys 
    210                 215                 220                 


Glu Asp Gly Glu Phe Asp Ser Lys Glu Glu Ser Lys Gln Lys Leu Val 
225                 230                 235                 240 


Ser Phe Cys Ser Gln Pro Ser Val Ile Ser Ser Pro Gln Ile Asn Gly 
                245                 250                 255     


Glu Ile Asp Leu Leu Ala Ser Gly Ser Leu Thr Glu Ser Glu Cys Phe 
            260                 265                 270         


Gly Ser Leu Thr Glu Val Ser Leu Pro Leu Ala Glu Gln Ile Glu Ser 
        275                 280                 285             


Pro Asp Thr Lys Ser Arg Asn Glu Val Val Thr Pro Glu Lys Val Cys 
    290                 295                 300                 


Lys Asn Tyr Leu Thr Ser Lys Lys Ser Leu Pro Leu Glu Asn Asn Gly 
305                 310                 315                 320 


Lys Arg Gly His His Asn Arg Leu Ser Ser Pro Ile Ser Lys Arg Cys 
                325                 330                 335     


Arg Thr Ser Ile Leu Ser Thr Ser Gly Asp Phe Val Lys Gln Thr Val 
            340                 345                 350         


Pro Ser Glu Asn Ile Pro Leu Pro Glu Cys Ser Ser Pro Pro Ser Cys 
        355                 360                 365             


Lys Arg Lys Val Gly Gly Thr Ser Gly Arg Lys Asn Ser Asn Met Ser 
    370                 375                 380                 


Asp Glu Phe Ile Ser Leu Ser Pro Gly Thr Pro Pro Ser Thr Leu Ser 
385                 390                 395                 400 


Ser Ser Ser Tyr Arg Arg Val Met Ser Ser Pro Ser Ala Met Lys Leu 
                405                 410                 415     


Leu Pro Asn Met Ala Val Lys Arg Asn His Arg Gly Glu Thr Leu Leu 
            420                 425                 430         


His Ile Ala Ser Ile Lys Gly Asp Ile Pro Ser Val Glu Tyr Leu Leu 
        435                 440                 445             


Gln Asn Gly Ser Asp Pro Asn Val Lys Asp His Ala Gly Trp Thr Pro 
    450                 455                 460                 


Leu His Glu Ala Cys Asn His Gly His Leu Lys Val Val Glu Leu Leu 
465                 470                 475                 480 


Leu Gln His Lys Ala Leu Val Asn Thr Thr Gly Tyr Gln Asn Asp Ser 
                485                 490                 495     


Pro Leu His Asp Ala Ala Lys Asn Gly His Val Asp Ile Val Lys Leu 
            500                 505                 510         


Leu Leu Ser Tyr Gly Ala Ser Arg Asn Ala Val Asn Ile Phe Gly Leu 
        515                 520                 525             


Arg Pro Val Asp Tyr Thr Asp Asp Glu Ser Met Lys Ser Leu Leu Leu 
    530                 535                 540                 


Leu Pro Glu Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met 
545                 550                 555                 560 


Asn Thr Gly Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly 
                565                 570                 575     


Leu Ser Ser Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu 
            580                 585                 590         


Lys Ala Lys Lys Tyr Thr Glu Phe Asp Ser Thr Val Thr His Val Val 
        595                 600                 605             


Val Pro Gly Asp Ala Val Gln Ser Thr Leu Lys Cys Met Leu Gly Ile 
    610                 615                 620                 


Leu Asn Gly Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu 
625                 630                 635                 640 


Arg Arg Lys Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly 
                645                 650                 655     


Pro Arg Arg Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe 
            660                 665                 670         


Asp Gly Cys Tyr Phe Tyr Leu Trp Gly Thr Phe Lys His His Pro Lys 
        675                 680                 685             


Asp Asn Leu Ile Lys Leu Val Thr Ala Gly Gly Gly Gln Ile Leu Ser 
    690                 695                 700                 


Arg Lys Pro Lys Pro Asp Ser Asp Val Thr Gln Thr Ile Asn Thr Val 
705                 710                 715                 720 


Ala Tyr His Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Thr Gln Tyr 
                725                 730                 735     


Ile Ile Tyr Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln 
            740                 745                 750         


Gly Lys Val Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met 
        755                 760                 765             


Ser Phe Glu Leu Leu Pro Leu Asp Ser 
    770                 775         


<210>  44
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Asn Cys Val Ser Asp Cys Ile Gly Thr Gly Cys 
    50                  55                  60                  


Pro Val Cys Tyr Thr Pro Ala Trp Ile Gln Asp Leu Lys Ile Asn Arg 
65                  70                  75                  80  


Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg Asn Leu Leu 
                85                  90                  95      


His Asp Asn Glu Leu Ser Asp Leu Lys Glu Asp Lys Pro Arg Lys Ser 
            100                 105                 110         


Leu Phe Asn Asp Ala Gly Asn Lys Lys Asn Ser Ile Lys Met Trp Phe 
        115                 120                 125             


Ser Pro Arg Ser Lys Lys Val Arg Tyr Val Val Ser Lys Ala Ser Val 
    130                 135                 140                 


Gln Thr Gln Pro Ala Ile Lys Lys Asp Ala Ser Ala Gln Gln Asp Ser 
145                 150                 155                 160 


Tyr Glu Phe Val Ser Pro Ser Pro Pro Ala Asp Val Ser Glu Arg Ala 
                165                 170                 175     


Lys Lys Ala Ser Ala Arg Ser Gly Lys Lys Gln Lys Lys Lys Thr Leu 
            180                 185                 190         


Ala Glu Ile Asn Gln Lys Trp Asn Leu Glu Ala Glu Lys Glu Asp Gly 
        195                 200                 205             


Glu Phe Asp Ser Lys Glu Glu Ser Lys Gln Lys Leu Val Ser Phe Cys 
    210                 215                 220                 


Ser Gln Pro Ser Val Ile Ser Ser Pro Gln Ile Asn Gly Glu Ile Asp 
225                 230                 235                 240 


Leu Leu Ala Ser Gly Ser Leu Thr Glu Ser Glu Cys Phe Gly Ser Leu 
                245                 250                 255     


Thr Glu Val Ser Leu Pro Leu Ala Glu Gln Ile Glu Ser Pro Asp Thr 
            260                 265                 270         


Lys Ser Arg Asn Glu Val Val Thr Pro Glu Lys Val Cys Lys Asn Tyr 
        275                 280                 285             


Leu Thr Ser Lys Lys Ser Leu Pro Leu Glu Asn Asn Gly Lys Arg Gly 
    290                 295                 300                 


His His Asn Arg Leu Ser Ser Pro Ile Ser Lys Arg Cys Arg Thr Ser 
305                 310                 315                 320 


Ile Leu Ser Thr Ser Gly Asp Phe Val Lys Gln Thr Val Pro Ser Glu 
                325                 330                 335     


Asn Ile Pro Leu Pro Glu Cys Ser Ser Pro Pro Ser Cys Lys Arg Lys 
            340                 345                 350         


Val Gly Gly Thr Ser Gly Arg Lys Asn Ser Asn Met Ser Asp Glu Phe 
        355                 360                 365             


Ile Ser Leu Ser Pro Gly Thr Pro Pro Ser Thr Leu Ser Ser Ser Ser 
    370                 375                 380                 


Tyr Arg Arg Val Met Ser Ser Pro Ser Ala Met Lys Leu Leu Pro Asn 
385                 390                 395                 400 


Met Ala Val Lys Arg Asn His Arg Gly Glu Thr Leu Leu His Ile Ala 
                405                 410                 415     


Ser Ile Lys Gly Asp Ile Pro Ser Val Glu Tyr Leu Leu Gln Asn Gly 
            420                 425                 430         


Ser Asp Pro Asn Val Lys Asp His Ala Gly Trp Thr Pro Leu His Glu 
        435                 440                 445             


Ala Cys Asn His Gly His Leu Lys Val Val Glu Leu Leu Leu Gln His 
    450                 455                 460                 


Lys Ala Leu Val Asn Thr Thr Gly Tyr Gln Asn Asp Ser Pro Leu His 
465                 470                 475                 480 


Asp Ala Ala Lys Asn Gly His Val Asp Ile Val Lys Leu Leu Leu Ser 
                485                 490                 495     


Tyr Gly Ala Ser Arg Asn Ala Val Asn Ile Phe Gly Leu Arg Pro Val 
            500                 505                 510         


Asp Tyr Thr Asp Asp Glu Ser Met Lys Ser Leu Leu Leu Leu Pro Glu 
        515                 520                 525             


Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met Asn Thr Gly 
    530                 535                 540                 


Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly Leu Ser Ser 
545                 550                 555                 560 


Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu Lys Ala Lys 
                565                 570                 575     


Lys Tyr Thr Glu Phe Asp Ser Thr Val Thr His Val Val Val Pro Gly 
            580                 585                 590         


Asp Ala Val Gln Ser Thr Leu Lys Cys Met Leu Gly Ile Leu Asn Gly 
        595                 600                 605             


Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu Arg Arg Lys 
    610                 615                 620                 


Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro Arg Arg 
625                 630                 635                 640 


Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe Asp Gly Cys 
                645                 650                 655     


Tyr Phe Tyr Leu Trp Gly Thr Phe Lys His His Pro Lys Asp Asn Leu 
            660                 665                 670         


Ile Lys Leu Val Thr Ala Gly Gly Gly Gln Ile Leu Ser Arg Lys Pro 
        675                 680                 685             


Lys Pro Asp Ser Asp Val Thr Gln Thr Ile Asn Thr Val Ala Tyr His 
    690                 695                 700                 


Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Thr Gln Tyr Ile Ile Tyr 
705                 710                 715                 720 


Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln Gly Lys Val 
                725                 730                 735     


Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met Ser Phe Glu 
            740                 745                 750         


Leu Leu Pro Leu Asp Ser 
        755             


<210>  45
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Ala Val Pro Gly Pro Thr Val Ala Pro Arg Ser Thr Ala Trp 
1               5                   10                  15      


Arg Ser Cys Cys Ala Ala Arg Val Asp Leu Lys Glu Asp Lys Pro Arg 
            20                  25                  30          


Lys Ser Leu Phe Asn Asp Ala Gly Asn Lys Lys Asn Ser Ile Lys Met 
        35                  40                  45              


Trp Phe Ser Pro Arg Ser Lys Lys Val Arg Tyr Val Val Ser Lys Ala 
    50                  55                  60                  


Ser Val Gln Thr Gln Pro Ala Ile Lys Lys Asp Ala Ser Ala Gln Gln 
65                  70                  75                  80  


Asp Ser Tyr Glu Phe Val Ser Pro Ser Pro Pro Ala Asp Val Ser Glu 
                85                  90                  95      


Arg Ala Lys Lys Ala Ser Ala Arg Ser Gly Lys Lys Gln Lys Lys Lys 
            100                 105                 110         


Thr Leu Ala Glu Ile Asn Gln Lys Trp Asn Leu Glu Ala Glu Lys Glu 
        115                 120                 125             


Asp Gly Glu Phe Asp Ser Lys Glu Glu Ser Lys Gln Lys Leu Val Ser 
    130                 135                 140                 


Phe Cys Ser Gln Pro Ser Val Ile Ser Ser Pro Gln Ile Asn Gly Glu 
145                 150                 155                 160 


Ile Asp Leu Leu Ala Ser Gly Ser Leu Thr Glu Ser Glu Cys Phe Gly 
                165                 170                 175     


Ser Leu Thr Glu Val Ser Leu Pro Leu Ala Glu Gln Ile Glu Ser Pro 
            180                 185                 190         


Asp Thr Lys Ser Arg Asn Glu Val Val Thr Pro Glu Lys Val Cys Lys 
        195                 200                 205             


Asn Tyr Leu Thr Ser Lys Lys Ser Leu Pro Leu Glu Asn Asn Gly Lys 
    210                 215                 220                 


Arg Gly His His Asn Arg Leu Ser Ser Pro Ile Ser Lys Arg Cys Arg 
225                 230                 235                 240 


Thr Ser Ile Leu Ser Thr Ser Gly Asp Phe Val Lys Gln Thr Val Pro 
                245                 250                 255     


Ser Glu Asn Ile Pro Leu Pro Glu Cys Ser Ser Pro Pro Ser Cys Lys 
            260                 265                 270         


Arg Lys Val Gly Gly Thr Ser Gly Arg Lys Asn Ser Asn Met Ser Asp 
        275                 280                 285             


Glu Phe Ile Ser Leu Ser Pro Gly Thr Pro Pro Ser Thr Leu Ser Ser 
    290                 295                 300                 


Ser Ser Tyr Arg Arg Val Met Ser Ser Pro Ser Ala Met Lys Leu Leu 
305                 310                 315                 320 


Pro Asn Met Ala Val Lys Arg Asn His Arg Gly Glu Thr Leu Leu His 
                325                 330                 335     


Ile Ala Ser Ile Lys Gly Asp Ile Pro Ser Val Glu Tyr Leu Leu Gln 
            340                 345                 350         


Asn Gly Ser Asp Pro Asn Val Lys Asp His Ala Gly Trp Thr Pro Leu 
        355                 360                 365             


His Glu Ala Cys Asn His Gly His Leu Lys Val Val Glu Leu Leu Leu 
    370                 375                 380                 


Gln His Lys Ala Leu Val Asn Thr Thr Gly Tyr Gln Asn Asp Ser Pro 
385                 390                 395                 400 


Leu His Asp Ala Ala Lys Asn Gly His Val Asp Ile Val Lys Leu Leu 
                405                 410                 415     


Leu Ser Tyr Gly Ala Ser Arg Asn Ala Val Asn Ile Phe Gly Leu Arg 
            420                 425                 430         


Pro Val Asp Tyr Thr Asp Asp Glu Ser Met Lys Ser Leu Leu Leu Leu 
        435                 440                 445             


Pro Glu Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met Asn 
    450                 455                 460                 


Thr Gly Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly Leu 
465                 470                 475                 480 


Ser Ser Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu Lys 
                485                 490                 495     


Ala Lys Lys Tyr Thr Glu Phe Asp Ser Thr Val Thr His Val Val Val 
            500                 505                 510         


Pro Gly Asp Ala Val Gln Ser Thr Leu Lys Cys Met Leu Gly Ile Leu 
        515                 520                 525             


Asn Gly Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu Arg 
    530                 535                 540                 


Arg Lys Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro 
545                 550                 555                 560 


Arg Arg Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe Asp 
                565                 570                 575     


Gly Cys Tyr Phe Tyr Leu Trp Gly Thr Phe Lys His His Pro Lys Asp 
            580                 585                 590         


Asn Leu Ile Lys Leu Val Thr Ala Gly Gly Gly Gln Ile Leu Ser Arg 
        595                 600                 605             


Lys Pro Lys Pro Asp Ser Asp Val Thr Gln Thr Ile Asn Thr Val Ala 
    610                 615                 620                 


Tyr His Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Thr Gln Tyr Ile 
625                 630                 635                 640 


Ile Tyr Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln Gly 
                645                 650                 655     


Lys Val Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met Ser 
            660                 665                 670         


Phe Glu Leu Leu Pro Leu Asp Ser 
        675                 680 


<210>  46
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Thr Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Cys Val Ser Asp Cys Ile Gly 
65                  70                  75                  80  


Thr Gly Cys Pro Val Cys Tyr Thr Pro Ala Trp Ile Gln Asp Leu Lys 
                85                  90                  95      


Ile Asn Arg Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg 
            100                 105                 110         


Asn Leu Leu His Asp Asn Glu Leu Ser Gly Arg His Thr Phe Cys 
        115                 120                 125         


<210>  47
<211>  1249
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Ser Met Trp Ser Glu Tyr Thr Ile Gly Gly Val Lys Ile Tyr 
1               5                   10                  15      


Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu Ala Met Met Asn Ser Ile 
            20                  25                  30          


Leu Arg Gly Leu Asn Ser Lys Gln His Cys Leu Leu Glu Ser Pro Thr 
        35                  40                  45              


Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys Ser Ala Leu Ala Trp Gln 
    50                  55                  60                  


Gln Ser Leu Ser Gly Lys Pro Ala Asp Glu Gly Val Ser Glu Lys Ala 
65                  70                  75                  80  


Glu Val Gln Leu Ser Cys Cys Cys Ala Cys His Ser Lys Asp Phe Thr 
                85                  90                  95      


Asn Asn Asp Met Asn Gln Gly Thr Ser Arg His Phe Asn Tyr Pro Ser 
            100                 105                 110         


Thr Pro Pro Ser Glu Arg Asn Gly Thr Ser Ser Thr Cys Gln Asp Ser 
        115                 120                 125             


Pro Glu Lys Thr Thr Leu Ala Ala Lys Leu Ser Ala Lys Lys Gln Ala 
    130                 135                 140                 


Ser Ile Tyr Arg Asp Glu Asn Asp Asp Phe Gln Val Glu Lys Lys Arg 
145                 150                 155                 160 


Ile Arg Pro Leu Glu Thr Thr Gln Gln Ile Arg Lys Arg His Cys Phe 
                165                 170                 175     


Gly Thr Glu Val His Asn Leu Asp Ala Lys Val Asp Ser Gly Lys Thr 
            180                 185                 190         


Val Lys Leu Asn Ser Pro Leu Glu Lys Ile Asn Ser Phe Ser Pro Gln 
        195                 200                 205             


Lys Pro Pro Gly His Cys Ser Arg Cys Cys Cys Ser Thr Lys Gln Gly 
    210                 215                 220                 


Asn Ser Gln Glu Ser Ser Asn Thr Ile Lys Lys Asp His Thr Gly Lys 
225                 230                 235                 240 


Ser Lys Ile Pro Lys Ile Tyr Phe Gly Thr Arg Thr His Lys Gln Ile 
                245                 250                 255     


Ala Gln Ile Thr Arg Glu Leu Arg Arg Thr Ala Tyr Ser Gly Val Pro 
            260                 265                 270         


Met Thr Ile Leu Ser Ser Arg Asp His Thr Cys Val His Pro Glu Val 
        275                 280                 285             


Val Gly Asn Phe Asn Arg Asn Glu Lys Cys Met Glu Leu Leu Asp Gly 
    290                 295                 300                 


Lys Asn Gly Lys Ser Cys Tyr Phe Tyr His Gly Val His Lys Ile Ser 
305                 310                 315                 320 


Asp Gln His Thr Leu Gln Thr Phe Gln Gly Met Cys Lys Ala Trp Asp 
                325                 330                 335     


Ile Glu Glu Leu Val Ser Leu Gly Lys Lys Leu Lys Ala Cys Pro Tyr 
            340                 345                 350         


Tyr Thr Ala Arg Glu Leu Ile Gln Asp Ala Asp Ile Ile Phe Cys Pro 
        355                 360                 365             


Tyr Asn Tyr Leu Leu Asp Ala Gln Ile Arg Glu Ser Met Asp Leu Asn 
    370                 375                 380                 


Leu Lys Glu Gln Val Val Ile Leu Asp Glu Ala His Asn Ile Glu Asp 
385                 390                 395                 400 


Cys Ala Arg Glu Ser Ala Ser Tyr Ser Val Thr Glu Val Gln Leu Arg 
                405                 410                 415     


Phe Ala Arg Asp Glu Leu Asp Ser Met Val Asn Asn Asn Ile Arg Lys 
            420                 425                 430         


Lys Asp His Glu Pro Leu Arg Ala Val Cys Cys Ser Leu Ile Asn Trp 
        435                 440                 445             


Leu Glu Ala Asn Ala Glu Tyr Leu Val Glu Arg Asp Tyr Glu Ser Ala 
    450                 455                 460                 


Cys Lys Ile Trp Ser Gly Asn Glu Met Leu Leu Thr Leu His Lys Met 
465                 470                 475                 480 


Gly Ile Thr Thr Ala Thr Phe Pro Ile Leu Gln Gly His Phe Ser Ala 
                485                 490                 495     


Val Leu Gln Lys Glu Glu Lys Ile Ser Pro Ile Tyr Gly Lys Glu Glu 
            500                 505                 510         


Ala Arg Glu Val Pro Val Ile Ser Ala Ser Thr Gln Ile Met Leu Lys 
        515                 520                 525             


Gly Leu Phe Met Val Leu Asp Tyr Leu Phe Arg Gln Asn Ser Arg Phe 
    530                 535                 540                 


Ala Asp Asp Tyr Lys Ile Ala Ile Gln Gln Thr Tyr Ser Trp Thr Asn 
545                 550                 555                 560 


Gln Ile Asp Ile Ser Asp Lys Asn Gly Leu Leu Val Leu Pro Lys Asn 
                565                 570                 575     


Lys Lys Arg Ser Arg Gln Lys Thr Ala Val His Val Leu Asn Phe Trp 
            580                 585                 590         


Cys Leu Asn Pro Ala Val Ala Phe Ser Asp Ile Asn Gly Lys Val Gln 
        595                 600                 605             


Thr Ile Val Leu Thr Ser Gly Thr Leu Ser Pro Met Lys Ser Phe Ser 
    610                 615                 620                 


Ser Glu Leu Gly Val Thr Phe Thr Ile Gln Leu Glu Ala Asn His Ile 
625                 630                 635                 640 


Ile Lys Asn Ser Gln Val Trp Val Gly Thr Ile Gly Ser Gly Pro Lys 
                645                 650                 655     


Gly Arg Asn Leu Cys Ala Thr Phe Gln Asn Thr Glu Thr Phe Glu Phe 
            660                 665                 670         


Gln Asp Glu Val Gly Ala Leu Leu Leu Ser Val Cys Gln Thr Val Ser 
        675                 680                 685             


Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr Lys Leu Leu Glu Lys Leu 
    690                 695                 700                 


Lys Glu Arg Trp Leu Ser Thr Gly Leu Trp His Asn Leu Glu Leu Val 
705                 710                 715                 720 


Lys Thr Val Ile Val Glu Pro Gln Gly Gly Glu Lys Thr Asn Phe Asp 
                725                 730                 735     


Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile Lys Tyr Lys Gly Glu Lys 
            740                 745                 750         


Asp Gly Ala Leu Leu Val Ala Val Cys Arg Gly Lys Val Ser Glu Gly 
        755                 760                 765             


Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala Val Ile Thr Ile Gly Ile 
    770                 775                 780                 


Pro Phe Pro Asn Val Lys Asp Leu Gln Val Glu Leu Lys Arg Gln Tyr 
785                 790                 795                 800 


Asn Asp His His Ser Lys Leu Arg Gly Leu Leu Pro Gly Arg Gln Trp 
                805                 810                 815     


Tyr Glu Ile Gln Ala Tyr Arg Ala Leu Asn Gln Ala Leu Gly Arg Cys 
            820                 825                 830         


Ile Arg His Arg Asn Asp Trp Gly Ala Leu Ile Leu Val Asp Asp Arg 
        835                 840                 845             


Phe Arg Asn Asn Pro Ser Arg Tyr Ile Ser Gly Leu Ser Lys Trp Val 
    850                 855                 860                 


Arg Gln Gln Ile Gln His His Ser Thr Phe Glu Ser Ala Leu Glu Ser 
865                 870                 875                 880 


Leu Ala Glu Phe Ser Lys Lys His Gln Lys Val Leu Asn Val Ser Ile 
                885                 890                 895     


Lys Asp Arg Thr Asn Ile Gln Asp Asn Glu Ser Thr Leu Glu Val Thr 
            900                 905                 910         


Ser Leu Lys Tyr Ser Thr Ser Pro Tyr Leu Leu Glu Ala Ala Ser His 
        915                 920                 925             


Leu Ser Pro Glu Asn Phe Val Glu Asp Glu Ala Lys Ile Cys Val Gln 
    930                 935                 940                 


Glu Leu Gln Cys Pro Lys Ile Ile Thr Lys Asn Ser Pro Leu Pro Ser 
945                 950                 955                 960 


Ser Ile Ile Ser Arg Lys Glu Lys Asn Asp Pro Val Phe Leu Glu Glu 
                965                 970                 975     


Ala Gly Lys Ala Glu Lys Ile Val Ile Ser Arg Ser Thr Ser Pro Thr 
            980                 985                 990         


Phe Asn Lys Gln Thr Lys Arg Val  Ser Trp Ser Ser Phe  Asn Ser Leu 
        995                 1000                 1005             


Gly Gln  Tyr Phe Thr Gly Lys  Ile Pro Lys Ala Thr  Pro Glu Leu 
    1010                 1015                 1020             


Gly Ser  Ser Glu Asn Ser Ala  Ser Ser Pro Pro Arg  Phe Lys Thr 
    1025                 1030                 1035             


Glu Lys  Met Glu Ser Lys Thr  Val Leu Pro Phe Thr  Asp Lys Cys 
    1040                 1045                 1050             


Glu Ser  Ser Asn Leu Thr Val  Asn Thr Ser Phe Gly  Ser Cys Pro 
    1055                 1060                 1065             


Gln Ser  Glu Thr Ile Ile Ser  Ser Leu Lys Ile Asp  Ala Thr Leu 
    1070                 1075                 1080             


Thr Arg  Lys Asn His Ser Glu  His Pro Leu Cys Ser  Glu Glu Ala 
    1085                 1090                 1095             


Leu Asp  Pro Asp Ile Glu Leu  Ser Leu Val Ser Glu  Glu Asp Lys 
    1100                 1105                 1110             


Gln Ser  Thr Ser Asn Arg Asp  Phe Glu Thr Glu Ala  Glu Asp Glu 
    1115                 1120                 1125             


Ser Ile  Tyr Phe Thr Pro Glu  Leu Tyr Asp Pro Glu  Asp Thr Asp 
    1130                 1135                 1140             


Glu Glu  Lys Asn Asp Leu Ala  Glu Thr Asp Arg Gly  Asn Arg Leu 
    1145                 1150                 1155             


Ala Asn  Asn Ser Asp Cys Ile  Leu Ala Lys Asp Leu  Phe Glu Ile 
    1160                 1165                 1170             


Arg Thr  Ile Lys Glu Val Asp  Ser Ala Arg Glu Val  Lys Ala Glu 
    1175                 1180                 1185             


Asp Cys  Ile Asp Thr Lys Leu  Asn Gly Ile Leu His  Ile Glu Glu 
    1190                 1195                 1200             


Ser Lys  Ile Asp Asp Ile Asp  Gly Asn Val Lys Thr  Thr Trp Ile 
    1205                 1210                 1215             


Asn Glu  Leu Glu Leu Gly Lys  Thr His Glu Ile Glu  Ile Lys Asn 
    1220                 1225                 1230             


Phe Lys  Pro Ser Pro Ser Lys  Asn Lys Gly Met Phe  Pro Gly Phe 
    1235                 1240                 1245             


Lys 
    


<210>  48
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Ser Met Trp Ser Glu Tyr Thr Ile Gly Gly Val Lys Ile Tyr 
1               5                   10                  15      


Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu Ala Met Met Asn Ser Ile 
            20                  25                  30          


Leu Arg Gly Leu Asn Ser Lys Gln His Cys Leu Leu Glu Ser Pro Thr 
        35                  40                  45              


Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys Ser Ala Leu Ala Trp Gln 
    50                  55                  60                  


Gln Ser Leu Ser Gly Lys Pro Ala Asp Glu Gly Val Ser Glu Lys Ala 
65                  70                  75                  80  


Glu Val Gln Leu Ser Cys Cys Cys Ala Cys His Ser Lys Asp Phe Thr 
                85                  90                  95      


Asn Asn Asp Met Asn Gln Gly Thr Ser Arg His Phe Asn Tyr Pro Ser 
            100                 105                 110         


Thr Pro Pro Ser Glu Arg Asn Gly Thr Ser Ser Thr Cys Gln Asp Ser 
        115                 120                 125             


Pro Glu Lys Thr Thr Leu Ala Ala Lys Leu Ser Ala Lys Lys Gln Ala 
    130                 135                 140                 


Ser Ile Tyr Arg Asp Glu Asn Asp Asp Phe Gln Val Glu Lys Lys Arg 
145                 150                 155                 160 


Ile Arg Pro Leu Glu Thr Thr Gln Gln Ile Arg Lys Arg His Cys Phe 
                165                 170                 175     


Gly Thr Glu Val His Asn Leu Asp Ala Lys Val Asp Ser Gly Lys Thr 
            180                 185                 190         


Val Lys Leu Asn Ser Pro Leu Glu Lys Ile Asn Ser Phe Ser Pro Gln 
        195                 200                 205             


Lys Pro Pro Gly His Cys Ser Arg Cys Cys Cys Ser Thr Lys Gln Gly 
    210                 215                 220                 


Asn Ser Gln Glu Ser Ser Asn Thr Ile Lys Lys Asp His Thr Gly Lys 
225                 230                 235                 240 


Ser Lys Ile Pro Lys Ile Tyr Phe Gly Thr Arg Thr His Lys Gln Ile 
                245                 250                 255     


Ala Gln Ile Thr Arg Glu Leu Arg Arg Thr Ala Tyr Ser Gly Val Pro 
            260                 265                 270         


Met Thr Ile Leu Ser Ser Arg Asp His Thr Cys Val His Pro Glu Val 
        275                 280                 285             


Val Gly Asn Phe Asn Arg Asn Glu Lys Cys Met Glu Leu Leu Asp Gly 
    290                 295                 300                 


Lys Asn Gly Lys Ser Cys Tyr Phe Tyr His Gly Val His Lys Ile Ser 
305                 310                 315                 320 


Asp Gln His Thr Leu Gln Thr Phe Gln Gly Met Cys Lys Ala Trp Asp 
                325                 330                 335     


Ile Glu Glu Leu Val Ser Leu Gly Lys Lys Leu Lys Ala Cys Pro Tyr 
            340                 345                 350         


Tyr Thr Ala Arg Glu Leu Ile Gln Asp Ala Asp Ile Ile Phe Cys Pro 
        355                 360                 365             


Tyr Asn Tyr Leu Leu Asp Ala Gln Ile Arg Glu Ser Met Asp Leu Asn 
    370                 375                 380                 


Leu Lys Glu Gln Val Val Ile Leu Asp Glu Ala His Asn Ile Glu Asp 
385                 390                 395                 400 


Cys Ala Arg Glu Ser Ala Ser Tyr Ser Val Thr Glu Val Gln Leu Arg 
                405                 410                 415     


Phe Ala Arg Asp Glu Leu Asp Ser Met Val Asn Asn Asn Ile Arg Lys 
            420                 425                 430         


Lys Asp His Glu Pro Leu Arg Ala Val Cys Cys Ser Leu Ile Asn Trp 
        435                 440                 445             


Leu Glu Ala Asn Ala Glu Tyr Leu Val Glu Arg Asp Tyr Glu Ser Ala 
    450                 455                 460                 


Cys Lys Ile Trp Ser Gly Asn Glu Met Leu Leu Thr Leu His Lys Met 
465                 470                 475                 480 


Gly Ile Thr Thr Ala Thr Phe Pro Ile Leu Gln Gly His Phe Ser Ala 
                485                 490                 495     


Val Leu Gln Lys Glu Glu Lys Ile Ser Pro Ile Tyr Gly Lys Glu Glu 
            500                 505                 510         


Ala Arg Glu Val Pro Val Ile Ser Ala Ser Thr Gln Ile Met Leu Lys 
        515                 520                 525             


Gly Leu Phe Met Val Leu Asp Tyr Leu Phe Arg Gln Asn Ser Arg Phe 
    530                 535                 540                 


Ala Asp Asp Tyr Lys Ile Ala Ile Gln Gln Thr Tyr Ser Trp Thr Asn 
545                 550                 555                 560 


Gln Ile Asp Ile Ser Asp Lys Asn Gly Leu Leu Val Leu Pro Lys Asn 
                565                 570                 575     


Lys Lys Arg Ser Arg Gln Lys Thr Ala Val His Val Leu Asn Phe Trp 
            580                 585                 590         


Cys Leu Asn Pro Ala Val Ala Phe Ser Asp Ile Asn Gly Lys Val Gln 
        595                 600                 605             


Thr Ile Val Leu Thr Ser Gly Thr Leu Ser Pro Met Lys Ser Phe Ser 
    610                 615                 620                 


Ser Glu Leu Gly Val Thr Phe Thr Ile Gln Leu Glu Ala Asn His Ile 
625                 630                 635                 640 


Ile Lys Asn Ser Gln Val Trp Val Gly Thr Ile Gly Ser Gly Pro Lys 
                645                 650                 655     


Gly Arg Asn Leu Cys Ala Thr Phe Gln Asn Thr Glu Thr Phe Glu Phe 
            660                 665                 670         


Gln Asp Glu Val Gly Ala Leu Leu Leu Ser Val Cys Gln Thr Val Ser 
        675                 680                 685             


Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr Lys Leu Leu Glu Lys Leu 
    690                 695                 700                 


Lys Glu Arg Trp Leu Ser Thr Gly Leu Trp His Asn Leu Glu Leu Val 
705                 710                 715                 720 


Lys Thr Val Ile Val Glu Pro Gln Gly Gly Glu Lys Thr Asn Phe Asp 
                725                 730                 735     


Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile Lys Tyr Lys Gly Glu Lys 
            740                 745                 750         


Asp Gly Ala Leu Leu Val Ala Val Cys Arg Gly Lys Val Ser Glu Gly 
        755                 760                 765             


Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala Val Ile Thr Ile Gly Ile 
    770                 775                 780                 


Pro Phe Pro Asn Val Lys Asp Leu Gln Val Glu Leu Lys Arg Gln Tyr 
785                 790                 795                 800 


Asn Asp His His Ser Lys Leu Arg Gly Leu Leu Pro Gly Arg Gln Trp 
                805                 810                 815     


Tyr Glu Ile Gln Ala Tyr Arg Ala Leu Asn Gln Ala Leu Gly Arg Cys 
            820                 825                 830         


Ile Arg His Arg Asn Asp Trp Gly Ala Leu Ile Leu Val Asp Asp Arg 
        835                 840                 845             


Phe Arg Asn Asn Pro Ser Arg Tyr Ile Ser Gly Leu Ser Lys Trp Val 
    850                 855                 860                 


Arg Gln Gln Ile Gln His His Ser Thr Phe Glu Ser Ala Leu Glu Ser 
865                 870                 875                 880 


Leu Ala Glu Phe Ser Lys Lys His Gln Lys Val Leu Asn Val Ser Ile 
                885                 890                 895     


Lys Asp Arg Thr Asn Ile Gln Asp Asn Glu Ser Thr Leu Glu Val Thr 
            900                 905                 910         


Ser Leu Lys Tyr Ser Thr Ser Pro Tyr Leu Leu Glu Ala Ala Ser His 
        915                 920                 925             


Leu Ser Pro Glu Asn Phe Val Glu Asp Glu Ala Lys Ile Cys Val Gln 
    930                 935                 940                 


Glu Leu Gln Cys Pro Lys Ile Ile Thr Lys Asn Ser Pro Leu Pro Ser 
945                 950                 955                 960 


Ser Ile Ile Ser Arg Lys Glu Lys Ser Met Lys Ser Ser Ser His Leu 
                965                 970                 975     


Pro Leu Ile Glu Lys Ser Phe Ile Ile Phe Ser Glu Met Ile Phe Ile 
            980                 985                 990         


Trp Val 
        


<210>  49
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Thr Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Thr Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Thr His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Thr Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Thr Gly Leu Ser Leu Trp Asp Thr Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Thr Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Thr Pro Gly Ser Ser Gln Asn 
        355                 360                 365             


Pro Trp Gln Arg Leu Val Lys Arg Met Thr Arg Phe Phe Thr Lys Leu 
    370                 375                 380                 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Thr Cys Glu Lys Leu 
385                 390                 395                 400 


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Val Thr Ile Ser Thr 
                405                 410                 415     


Thr Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu Leu Glu 
            420                 425                 430         


Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly Asp Gly 
        435                 440                 445             


Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp 
    450                 455                 460                 


Ile Val Ser Ser Gln Lys Ile Trp Leu Pro Ala Thr 
465                 470                 475     


<210>  50
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Lys Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe 
1               5                   10                  15      


Phe His Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile 
            20                  25                  30          


Thr His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp 
        35                  40                  45              


Asn Leu Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn 
    50                  55                  60                  


Asn Arg Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp 
                85                  90                  95      


Val Trp Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu 
            100                 105                 110         


Pro Trp Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys 
        115                 120                 125             


Glu Lys Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro 
    130                 135                 140                 


Leu Ala Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile 
145                 150                 155                 160 


Thr Ile Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys 
                165                 170                 175     


Lys Gly Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser 
            180                 185                 190         


Pro Ser Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro 
        195                 200                 205             


Val Asn Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln 
    210                 215                 220                 


Pro Glu Pro Arg Thr Gly Leu Ser Leu Trp Asp Thr Ser Pro Ser Tyr 
225                 230                 235                 240 


Ile Asp Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Thr Cys Pro 
                245                 250                 255     


Asp His Met Leu Leu Asn Ser Gln Leu Leu Gly Thr Pro Gly Ser Ser 
            260                 265                 270         


Gln Asn Pro Trp Gln Arg Leu Val Lys Arg Met Thr Arg Phe Phe Thr 
        275                 280                 285             


Lys Leu Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Thr Cys Glu 
    290                 295                 300                 


Lys Leu Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Val Thr Ile 
305                 310                 315                 320 


Ser Thr Thr Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu 
                325                 330                 335     


Leu Glu Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly 
            340                 345                 350         


Asp Gly Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu 
        355                 360                 365             


Ile Asp Ile Val Ser Ser Gln Lys Ile Trp Leu Pro Ala Thr 
    370                 375                 380         


<210>  51
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Thr Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Thr Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Thr His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Thr Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Thr Gly Leu Ser Leu Trp Asp Thr Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Thr Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Thr Pro Gly Ser Ser Gln Asn 
        355                 360                 365             


Pro Trp Gln Arg Leu Val Lys Arg Met Thr Arg Phe Phe Thr Lys Leu 
    370                 375                 380                 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Thr Cys Glu Lys Leu 
385                 390                 395                 400 


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Gly Asp Gly Leu Glu 
                405                 410                 415     


Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp Ile Val 
            420                 425                 430         


Ser Ser Gln Lys Ile Trp Leu Pro Ala Thr 
        435                 440         


<210>  52
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
            340                 345                 350         


Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp 
        355                 360                 365             


Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu 
    370                 375                 380                 


Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly 
385                 390                 395                 400 


Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile 
                405                 410                 415     


Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr 
            420                 425                 430         


Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile 
        435                 440                 445             


Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys 
    450                 455                 460                 


Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala 
465                 470                 475                 480 


Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln 
                485                 490                 495     


Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu 
        515                 520                 525             


Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
    530                 535                 540             


<210>  53
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Glu Lys Ile Leu Lys Ile Tyr Ser Leu Ser Arg 
        195                 200                 205             


Phe Ser Lys Ile Arg Arg Gly Ala Val Ala His Val Phe Asn Pro Ser 
    210                 215                 220                 


Thr Leu Gly Gly Arg Gly Trp Gln Ile Thr 
225                 230                 


<210>  54
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Asp Glu Asp Met Lys Arg 
            100                 105                 110         


Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro 
        115                 120                 125             


Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly 
    130                 135                 140                 


Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala 
145                 150                 155                 160 


Val Leu 
        


<210>  55
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Val Phe Val Phe Phe Asp 
            100                 105                 110         


Leu Thr Val Asp Asp Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu 
        115                 120                 125             


Tyr Ile Met Ser Lys Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys 
    130                 135                 140                 


Leu Ala Phe Glu Arg Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile 
145                 150                 155                 160 


Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala 
                165                 170                 175     


Leu Asn Val Glu Thr Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro 
            180                 185                 190         


Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile 
        195                 200                 205             


Val Leu Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly 
    210                 215                 220                 


Asn Lys Arg Leu Lys Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met 
225                 230                 235                 240 


Leu Leu Ala Val Gln Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp 
                245                 250                 255     


Leu Lys Pro Glu Asn Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu 
            260                 265                 270         


Ile Lys Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser 
        275                 280                 285             


Leu Met Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val 
    290                 295                 300                 


Leu Val Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp 
305                 310                 315                 320 


Ser Leu Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe 
                325                 330                 335     


Ser Glu His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly 
            340                 345                 350         


Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala 
        355                 360                 365             


Leu Asp Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe 
    370                 375                 380                 


Thr Thr Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met 
385                 390                 395                 400 


Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala 
                405                 410                 415     


Leu Pro Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg 
            420                 425                 430         


Glu Gly Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys 
        435                 440                 445             


Ala Ala Val Leu 
    450         


<210>  56
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Val Pro Val Glu Arg 
        195                 200             


<210>  57
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Glu Asn Leu Ser Cys Pro Tyr Arg Ile Trp Phe 
145                 150                 155                 160 


Asn Phe Cys Leu Phe 
                165 


<210>  58
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Met Lys Thr 
            


<210>  59
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Asp Gly Arg Gly Arg Ala 
        275                 280                 285             


Val 
    


<210>  60
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Thr Glu Ser Gly His 
            100                 105                 110         


Val Thr Gln Ser Asp Leu Glu Leu Leu Leu Ser Ser Asp Pro Pro Ala 
        115                 120                 125             


Ser Ala Ser Gln Ser Ala Gly Ile Arg Gly Val Arg His His Pro Arg 
    130                 135                 140                 


Pro Val Cys Ser Leu Lys Cys Val Asn Asp Asn Tyr Trp Phe Gly Arg 
145                 150                 155                 160 


Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu Leu Lys Arg Thr 
                165                 170                 175     


Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe Arg Ile Phe Arg Glu 
            180                 185                 190         


Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp His Ser Gly 
        195                 200                 205             


Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly Lys Gly Lys Arg Arg 
    210                 215                 220                 


Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu Ser Arg Asn Lys 
225                 230                 235                 240 


Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp Gln Ser Val Tyr Pro 
                245                 250                 255     


Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys Thr Leu Gly Ser Gly 
            260                 265                 270         


Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys Thr Cys Lys Lys 
        275                 280                 285             


Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala 
    290                 295                 300                 


Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr Glu Ile Glu Ile Leu 
305                 310                 315                 320 


Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp 
                325                 330                 335     


Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly Glu Leu 
            340                 345                 350         


Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys Glu Ala Thr Cys Lys 
        355                 360                 365             


Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln Tyr Leu His Glu Asn 
    370                 375                 380                 


Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp Phe Gly His Ser Lys 
                405                 410                 415     


Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu Cys Gly Thr Pro Thr 
            420                 425                 430         


Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly Thr Ala Gly Tyr Asn 
        435                 440                 445             


Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile Leu Phe Ile Cys Leu 
    450                 455                 460                 


Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr Gln Val Ser Leu Lys 
465                 470                 475                 480 


Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala 
                485                 490                 495     


Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys Lys Leu Leu Val Val 
            500                 505                 510         


Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala Leu Arg His Pro Trp 
        515                 520                 525             


Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu 
    530                 535                 540                 


Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu Ala Gln Pro Ser Thr 
545                 550                 555                 560 


Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu Gly Ala Glu Thr Thr 
                565                 570                 575     


Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
            580                 585     


<210>  61
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Glu Phe Arg Ser Tyr Ser Phe Tyr Leu Pro 
    130                 135                 140 


<210>  62
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Val Leu Val Ser 
65                  70                  75                  80  


Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly 
                85                  90                  95      


Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu His 
            100                 105                 110         


Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr Asn 
        115                 120                 125             


Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp Leu 
    130                 135                 140                 


Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr Glu 
145                 150                 155                 160 


Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg Lys 
                165                 170                 175     


Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro Gln 
            180                 185                 190         


Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly Glu 
        195                 200                 205             


Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala Val 
    210                 215                 220                 


Leu 
225 


<210>  63
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met 
            340                 345                 350         


Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val 
        355                 360                 365             


Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu 
    370                 375                 380                 


Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu 
385                 390                 395                 400 


His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr 
                405                 410                 415     


Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp 
            420                 425                 430         


Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr 
        435                 440                 445             


Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg 
    450                 455                 460                 


Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro 
465                 470                 475                 480 


Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly 
                485                 490                 495     


Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala 
            500                 505                 510         


Val Leu 
        


<210>  64
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ser Lys Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala 
1               5                   10                  15      


Phe Glu Arg Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys 
            20                  25                  30          


Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn 
        35                  40                  45              


Val Glu Thr Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile 
    50                  55                  60                  


Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu 
65                  70                  75                  80  


Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys 
                85                  90                  95      


Arg Leu Lys Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu 
            100                 105                 110         


Ala Val Gln Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys 
        115                 120                 125             


Pro Glu Asn Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys 
    130                 135                 140                 


Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met 
145                 150                 155                 160 


Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val 
                165                 170                 175     


Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu 
            180                 185                 190         


Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu 
        195                 200                 205             


His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr 
    210                 215                 220                 


Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp 
225                 230                 235                 240 


Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr 
                245                 250                 255     


Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg 
            260                 265                 270         


Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro 
        275                 280                 285             


Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly 
    290                 295                 300                 


Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala 
305                 310                 315                 320 


Val Leu 
        


<210>  65
<211>  754
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Trp Lys Leu Leu Pro Ala Ala Gly Pro Ala Gly Gly Glu Pro Tyr 
1               5                   10                  15      


Arg Leu Leu Thr Gly Val Glu Tyr Val Val Gly Arg Lys Asn Cys Ala 
            20                  25                  30          


Ile Leu Ile Glu Asn Asp Gln Ser Ile Ser Arg Asn His Ala Val Leu 
        35                  40                  45              


Thr Ala Asn Phe Ser Val Thr Asn Leu Ser Gln Thr Asp Glu Ile Pro 
    50                  55                  60                  


Val Leu Thr Leu Lys Asp Asn Ser Lys Tyr Gly Thr Phe Val Asn Glu 
65                  70                  75                  80  


Glu Lys Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly 
                85                  90                  95      


Ile Thr Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro 
            100                 105                 110         


Leu Val Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu 
        115                 120                 125             


Asn Gln Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr 
    130                 135                 140                 


Glu Glu Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys 
145                 150                 155                 160 


Thr Ile Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr 
                165                 170                 175     


Phe Thr Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln 
            180                 185                 190         


Ile Glu Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys 
        195                 200                 205             


Asn Val Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly 
    210                 215                 220                 


Lys Thr Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser 
225                 230                 235                 240 


Ala Val Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn 
                245                 250                 255     


Glu Glu Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp 
            260                 265                 270         


Thr Gly Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys 
        275                 280                 285             


Trp Ile Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro 
    290                 295                 300                 


Ile Pro Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys 
305                 310                 315                 320 


Asn Tyr Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr 
                325                 330                 335     


Thr Pro Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu 
            340                 345                 350         


Met Pro Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu 
        355                 360                 365             


Ser Glu Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile 
    370                 375                 380                 


Lys Val Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala 
385                 390                 395                 400 


Pro Thr Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met 
                405                 410                 415     


Val Ser Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser 
            420                 425                 430         


Pro Thr Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln 
        435                 440                 445             


Gln Gln Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys 
    450                 455                 460                 


Lys Arg Glu Arg Asp Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser 
465                 470                 475                 480 


Ala Arg Ile Glu Thr Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala 
                485                 490                 495     


Thr Pro Ser Leu Trp Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu 
            500                 505                 510         


Pro Val Asp Thr Asn Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu 
        515                 520                 525             


Lys Ser Ile Val Lys Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys 
    530                 535                 540                 


Leu Arg Ser Asn Lys Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp 
545                 550                 555                 560 


Glu Val Leu Glu Gln Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile 
                565                 570                 575     


Asp Val Lys Val Gln Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg 
            580                 585                 590         


Pro Arg Met Asp Ile Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val 
        595                 600                 605             


Pro Glu Ser Ser Lys Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg 
    610                 615                 620                 


Glu Leu Lys Glu Asp Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn 
625                 630                 635                 640 


Asp Lys Leu Gln Asp Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu 
                645                 650                 655     


Thr Glu Phe Arg Ser Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro 
            660                 665                 670         


Ser Gly Ile Asn Asp Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe 
        675                 680                 685             


Lys Lys Val Thr Tyr Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly 
    690                 695                 700                 


Gly Ser Asp Leu Ile Ala His His Ala Arg Lys Asn Thr Glu Leu Glu 
705                 710                 715                 720 


Glu Trp Leu Arg Gln Glu Met Glu Val Gln Asn Gln His Ala Lys Glu 
                725                 730                 735     


Glu Ser Leu Ala Asp Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg 
            740                 745                 750         


Arg Arg 
        


<210>  66
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu Glu Lys Glu Lys 
1               5                   10                  15      


Leu Lys Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser Lys Thr Leu 
            20                  25                  30          


Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Lys Ile Lys His Ser Ile 
        35                  40                  45              


Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln Gln Asp Leu Ser 
    50                  55                  60                  


Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile Cys Val Tyr Asp 
65                  70                  75                  80  


Lys Leu His Ile Lys Thr His Leu Asp Glu Glu Thr Gly Glu Lys Thr 
                85                  90                  95      


Ser Ile Thr Leu Asp Val Gly Pro Glu Ser Phe Asn Pro Gly Asp Gly 
            100                 105                 110         


Pro Gly Gly Leu Pro Ile Gln Arg Thr Asp Asp Thr Gln Glu His Phe 
        115                 120                 125             


Pro His Arg Val Ser Asp Pro Ser Gly Glu Gln Lys Gln Lys Leu Pro 
    130                 135                 140                 


Ser Arg Arg Lys Lys Gln Gln Lys Arg Thr Phe Ile Ser Gln Glu Arg 
145                 150                 155                 160 


Asp Cys Val Phe Gly Thr Asp Ser Leu Arg Leu Ser Gly Lys Arg Leu 
                165                 170                 175     


Lys Glu Gln Glu Glu Ile Ser Ser Lys Asn Pro Ala Arg Ser Pro Val 
            180                 185                 190         


Thr Glu Ile Arg Thr His Leu Leu Ser Leu Lys Ser Glu Leu Pro Asp 
        195                 200                 205             


Ser Pro Glu Pro Val Thr Glu Ile Asn Glu Asp Ser Val Leu Ile Pro 
    210                 215                 220                 


Pro Thr Ala Gln Pro Glu Lys Gly Val Asp Thr Phe Leu Arg Arg Pro 
225                 230                 235                 240 


Asn Phe Thr Arg Ala Thr Thr Val Pro Leu Gln Thr Leu Ser Asp Ser 
                245                 250                 255     


Gly Ser Ser Gln His Leu Glu His Ile Pro Pro Lys Gly Ser Ser Glu 
            260                 265                 270         


Leu Thr Thr His Asp Leu Lys Asn Ile Arg Phe Thr Ser Pro Val Ser 
        275                 280                 285             


Leu Glu Ala Gln Gly Lys Lys Met Thr Val Ser Thr Asp Asn Leu Leu 
    290                 295                 300                 


Val Asn Lys Ala Ile Ser Lys Ser Gly Gln Leu Pro Thr Ser Ser Asn 
305                 310                 315                 320 


Leu Glu Ala Asn Ile Ser Cys Ser Leu Asn Glu Leu Thr Tyr Asn Asn 
                325                 330                 335     


Leu Pro Ala Asn Glu Asn Gln Asn Leu Lys Glu Gln Asn Gln Thr Glu 
            340                 345                 350         


Lys Ser Leu Lys Ser Pro Ser Asp Thr Leu Asp Gly Arg Asn Glu Asn 
        355                 360                 365             


Leu Gln Glu Ser Glu Ile Leu Ser Gln Pro Lys Ser Leu Ser Leu Glu 
    370                 375                 380                 


Ala Thr Ser Pro Leu Ser Ala Glu Lys His Ser Cys Thr Val Pro Glu 
385                 390                 395                 400 


Gly Leu Leu Phe Pro Ala Glu Tyr Tyr Val Arg Thr Thr Arg Ser Met 
                405                 410                 415     


Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser His 
            420                 425                 430         


Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala Ser 
        435                 440                 445             


Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile Arg 
    450                 455                 460                 


Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln Lys 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu Asp 
                485                 490                 495     


Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg Tyr 
            500                 505                 510         


Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys Glu 
        515                 520                 525             


Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys Glu 
    530                 535                 540                 


Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln Val 
545                 550                 555                 560 


Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp Ser 
                565                 570                 575     


Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro Phe 
            580                 585                 590         


His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser 
        595                 600                 605             


Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu 
    610                 615                 620                 


Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser 
625                 630                 635                 640 


Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro 
                645                 650                 655     


Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu 
            660                 665                 670         


Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn 
        675                 680                 685             


Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu 
    690                 695                 700                 


Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr 
705                 710                 715                 720 


Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala 
                725                 730                 735     


Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly 
            740                 745                 750         


Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys 
        755                 760                 765             


Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys 
    770                 775                 780                 


Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys 
785                 790                 795                 800 


Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe 
                805                 810                 815     


Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His 
            820                 825                 830         


Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp 
        835                 840                 845             


Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro 
    850                 855                 860                 


Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala 
865                 870                 875                 880 


Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser 
                885                 890                 895     


Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp 
            900                 905                 910         


His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val 
        915                 920                 925             


Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile 
    930                 935                 940                 


Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu 
945                 950                 955                 960 


Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg 
                965                 970                 975     


Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met 
            980                 985                 990         


Thr Phe Ala Glu Asp Gly Gly Gly  Lys Glu Asn Gln Phe  Leu Met Pro 
        995                 1000                 1005             


Pro Glu  Glu Thr Ile Leu Thr  Phe Ala Glu Val Gln  Gly Met Gln 
    1010                 1015                 1020             


Glu Ala  Leu Leu Gly Thr Thr  Ile Met Asn Asn Ile  Val Ile Trp 
    1025                 1030                 1035             


Asn Leu  Lys Thr Gly Gln Leu  Leu Lys Lys Met His  Ile Asp Asp 
    1040                 1045                 1050             


Ser Tyr  Gln Ala Ser Val Cys  His Lys Ala Tyr Ser  Glu Met Gly 
    1055                 1060                 1065             


Leu Leu  Phe Ile Val Leu Ser  His Pro Cys Ala Lys  Glu Ser Glu 
    1070                 1075                 1080             


Ser Leu  Arg Ser Pro Val Phe  Gln Leu Ile Val Ile  Asn Pro Lys 
    1085                 1090                 1095             


Thr Thr  Leu Ser Val Gly Val  Met Leu Tyr Cys Leu  Pro Pro Gly 
    1100                 1105                 1110             


Gln Ala  Gly Arg Phe Leu Glu  Gly Asp Val Lys Asp  His Cys Ala 
    1115                 1120                 1125             


Ala Ala  Ile Leu Thr Ser Gly  Thr Ile Ala Ile Trp  Asp Leu Leu 
    1130                 1135                 1140             


Leu Gly  Gln Cys Thr Ala Leu  Leu Pro Pro Val Ser  Asp Gln His 
    1145                 1150                 1155             


Trp Ser  Phe Val Lys Trp Ser  Gly Thr Asp Ser His  Leu Leu Ala 
    1160                 1165                 1170             


Gly Gln  Lys Asp Gly Asn Ile  Phe Val Tyr His Tyr  Ser 
    1175                 1180                 1185     


<210>  67
<211>  1834
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Lys Leu Ser Val Asn Glu Ala Gln Leu Gly Phe Tyr Leu Gly Ser 
1               5                   10                  15      


Leu Ser His Leu Ser Ala Cys Pro Gly Ile Asp Pro Arg Ser Ser Glu 
            20                  25                  30          


Asp Gln Pro Glu Ser Leu Lys Thr Gly Gln Met Met Asp Glu Ser Asp 
        35                  40                  45              


Glu Asp Phe Lys Glu Leu Cys Ala Ser Phe Phe Gln Arg Val Lys Lys 
    50                  55                  60                  


His Gly Ile Lys Glu Val Ser Gly Glu Arg Lys Thr Gln Lys Ala Ala 
65                  70                  75                  80  


Ser Asn Gly Thr Gln Ile Arg Ser Lys Leu Lys Arg Thr Lys Gln Thr 
                85                  90                  95      


Ala Thr Lys Thr Lys Thr Leu Gln Gly Pro Ala Glu Lys Lys Pro Pro 
            100                 105                 110         


Ser Gly Ser Gln Ala Pro Arg Thr Lys Lys Gln Arg Val Thr Lys Trp 
        115                 120                 125             


Gln Ala Ser Glu Pro Ala His Ser Val Asn Gly Glu Gly Gly Val Leu 
    130                 135                 140                 


Ala Ser Ala Pro Asp Pro Pro Val Leu Arg Glu Thr Ala Gln Asn Thr 
145                 150                 155                 160 


Gln Thr Gly Asn Gln Gln Glu Pro Ser Pro Asn Leu Ser Arg Glu Lys 
                165                 170                 175     


Thr Arg Glu Asn Val Pro Asn Ser Asp Ser Gln Pro Pro Pro Ser Cys 
            180                 185                 190         


Leu Thr Thr Ala Val Pro Ser Pro Ser Lys Pro Arg Thr Ala Gln Leu 
        195                 200                 205             


Val Leu Gln Arg Met Gln Gln Phe Lys Arg Ala Asp Pro Glu Arg Leu 
    210                 215                 220                 


Arg His Ala Ser Glu Glu Cys Ser Leu Glu Ala Ala Arg Glu Glu Asn 
225                 230                 235                 240 


Val Pro Lys Asp Pro Gln Glu Glu Met Met Ala Gly Asn Val Tyr Gly 
                245                 250                 255     


Leu Gly Pro Pro Ala Pro Glu Ser Asp Ala Ala Val Ala Leu Thr Leu 
            260                 265                 270         


Gln Gln Glu Phe Ala Arg Val Gly Ala Ser Ala His Asp Asp Ser Leu 
        275                 280                 285             


Glu Glu Lys Gly Leu Phe Phe Cys Gln Ile Cys Gln Lys Asn Leu Ser 
    290                 295                 300                 


Ala Met Asn Val Thr Arg Arg Glu Gln His Val Asn Arg Cys Leu Asp 
305                 310                 315                 320 


Glu Ala Glu Lys Thr Leu Arg Pro Ser Val Pro Gln Ile Pro Glu Cys 
                325                 330                 335     


Pro Ile Cys Gly Lys Pro Phe Leu Thr Leu Lys Ser Arg Thr Ser His 
            340                 345                 350         


Leu Lys Gln Cys Ala Val Lys Met Glu Val Gly Pro Gln Leu Leu Leu 
        355                 360                 365             


Gln Ala Val Arg Leu Gln Thr Ala Gln Pro Glu Gly Ser Ser Ser Pro 
    370                 375                 380                 


Pro Met Phe Ser Phe Ser Asp His Ser Arg Gly Leu Lys Arg Arg Gly 
385                 390                 395                 400 


Pro Thr Ser Lys Lys Glu Pro Arg Lys Arg Arg Lys Val Asp Glu Ala 
                405                 410                 415     


Pro Ser Glu Asp Leu Leu Val Ala Met Ala Leu Ser Arg Ser Glu Met 
            420                 425                 430         


Glu Pro Gly Ala Ala Val Pro Ala Leu Arg Leu Glu Ser Ala Phe Ser 
        435                 440                 445             


Glu Arg Ile Arg Pro Glu Ala Glu Asn Lys Ser Arg Lys Lys Lys Pro 
    450                 455                 460                 


Pro Val Ser Pro Pro Leu Leu Leu Val Gln Asp Ser Glu Thr Thr Gly 
465                 470                 475                 480 


Arg Gln Ile Glu Asp Arg Val Ala Leu Leu Leu Ser Glu Glu Val Glu 
                485                 490                 495     


Leu Ser Ser Thr Pro Pro Leu Pro Ala Ser Arg Ile Leu Lys Glu Gly 
            500                 505                 510         


Trp Glu Arg Ala Gly Gln Cys Pro Pro Pro Pro Glu Arg Lys Gln Ser 
        515                 520                 525             


Phe Leu Trp Glu Gly Ser Ala Leu Thr Gly Ala Trp Ala Met Glu Asp 
    530                 535                 540                 


Phe Tyr Thr Ala Arg Leu Val Pro Pro Leu Val Pro Gln Arg Pro Ala 
545                 550                 555                 560 


Gln Gly Leu Met Gln Glu Pro Val Pro Pro Leu Val Pro Pro Glu His 
                565                 570                 575     


Ser Glu Leu Ser Glu Arg Arg Ser Pro Ala Leu His Gly Thr Pro Thr 
            580                 585                 590         


Ala Gly Cys Gly Ser Arg Gly Pro Ser Pro Ser Ala Ser Gln Arg Glu 
        595                 600                 605             


His Gln Ala Leu Gln Asp Leu Val Asp Leu Ala Arg Glu Gly Leu Ser 
    610                 615                 620                 


Ala Ser Pro Trp Pro Gly Ser Gly Gly Leu Ala Gly Ser Glu Gly Thr 
625                 630                 635                 640 


Ala Gly Leu Asp Val Val Pro Gly Gly Leu Pro Leu Thr Gly Phe Val 
                645                 650                 655     


Val Pro Ser Gln Asp Lys His Pro Asp Arg Gly Gly Arg Thr Leu Leu 
            660                 665                 670         


Ser Leu Gly Leu Leu Val Ala Asp Phe Gly Ala Met Val Asn Asn Pro 
        675                 680                 685             


His Leu Ser Asp Val Gln Phe Gln Thr Asp Ser Gly Glu Val Leu Tyr 
    690                 695                 700                 


Ala His Lys Phe Val Leu Tyr Ala Arg Cys Pro Leu Leu Ile Gln Tyr 
705                 710                 715                 720 


Val Asn Asn Glu Gly Phe Ser Ala Val Glu Asp Gly Val Leu Thr Gln 
                725                 730                 735     


Arg Val Leu Leu Gly Asp Val Ser Thr Glu Ala Ala Arg Thr Phe Leu 
            740                 745                 750         


His Tyr Leu Tyr Thr Ala Asp Thr Gly Leu Pro Pro Gly Leu Ser Ser 
        755                 760                 765             


Glu Leu Ser Ser Leu Ala His Arg Phe Gly Val Ser Glu Leu Val His 
    770                 775                 780                 


Leu Cys Glu Gln Val Pro Ile Ala Thr Asp Ser Glu Gly Lys Pro Trp 
785                 790                 795                 800 


Glu Glu Lys Glu Ala Glu Asn Cys Glu Ser Arg Ala Glu Asn Phe Gln 
                805                 810                 815     


Glu Leu Leu Arg Ser Met Trp Ala Asp Glu Glu Glu Glu Ala Glu Thr 
            820                 825                 830         


Leu Leu Lys Ser Lys Asp His Glu Glu Asp Gln Glu Asn Val Asn Glu 
        835                 840                 845             


Ala Glu Met Glu Glu Ile Tyr Glu Phe Ala Ala Thr Gln Arg Lys Leu 
    850                 855                 860                 


Leu Gln Glu Glu Arg Ala Ala Gly Ala Gly Glu Asp Ala Asp Trp Leu 
865                 870                 875                 880 


Glu Gly Gly Ser Pro Val Ser Gly Gln Leu Leu Ala Gly Val Gln Val 
                885                 890                 895     


Gln Lys Gln Trp Asp Lys Val Glu Glu Met Glu Pro Leu Glu Pro Gly 
            900                 905                 910         


Arg Asp Glu Ala Ala Thr Thr Trp Glu Lys Met Gly Gln Cys Ala Leu 
        915                 920                 925             


Pro Pro Pro Gln Gly Gln His Ser Gly Ala Arg Gly Ala Glu Ala Pro 
    930                 935                 940                 


Glu Gln Glu Ala Pro Glu Glu Ala Leu Gly His Ser Ser Cys Ser Ser 
945                 950                 955                 960 


Pro Ser Arg Asp Cys Gln Ala Glu Arg Lys Glu Gly Ser Leu Pro His 
                965                 970                 975     


Ser Asp Asp Ala Gly Asp Tyr Glu Gln Leu Phe Ser Ser Thr Gln Gly 
            980                 985                 990         


Glu Ile Ser Glu Pro Ser Gln Ile  Thr Ser Glu Pro Glu  Glu Gln Ser 
        995                 1000                 1005             


Gly Ala  Val Arg Glu Arg Gly  Leu Glu Val Ser His  Arg Leu Ala 
    1010                 1015                 1020             


Pro Trp  Gln Ala Ser Pro Pro  His Pro Cys Arg Phe  Leu Leu Gly 
    1025                 1030                 1035             


Pro Pro  Gln Gly Gly Ser Pro  Arg Gly Ser His His  Thr Ser Gly 
    1040                 1045                 1050             


Ser Ser  Leu Ser Thr Pro Arg  Ser Arg Gly Gly Thr  Ser Gln Val 
    1055                 1060                 1065             


Gly Ser  Pro Thr Leu Leu Ser  Pro Ala Val Pro Ser  Lys Gln Lys 
    1070                 1075                 1080             


Arg Asp  Arg Ser Ile Leu Thr  Leu Ser Lys Glu Pro  Gly His Gln 
    1085                 1090                 1095             


Lys Gly  Lys Glu Arg Arg Ser  Val Leu Glu Cys Arg  Asn Lys Gly 
    1100                 1105                 1110             


Val Leu  Met Phe Pro Glu Lys  Ser Pro Ser Ile Asp  Leu Thr Gln 
    1115                 1120                 1125             


Ser Asn  Pro Asp His Ser Ser  Ser Arg Ser Gln Lys  Ser Ser Ser 
    1130                 1135                 1140             


Lys Leu  Asn Glu Glu Asp Glu  Val Ile Leu Leu Leu  Asp Ser Asp 
    1145                 1150                 1155             


Glu Glu  Leu Glu Leu Glu Gln  Thr Lys Met Lys Ser  Ile Ser Ser 
    1160                 1165                 1170             


Asp Pro  Leu Glu Glu Lys Lys  Ala Leu Glu Ile Ser  Pro Arg Ser 
    1175                 1180                 1185             


Cys Glu  Leu Phe Ser Ile Ile  Asp Val Asp Ala Asp  Gln Glu Pro 
    1190                 1195                 1200             


Ser Gln  Ser Pro Pro Arg Ser  Glu Ala Val Leu Gln  Gln Glu Asp 
    1205                 1210                 1215             


Glu Gly  Ala Leu Pro Glu Asn  Arg Gly Ser Leu Gly  Arg Arg Gly 
    1220                 1225                 1230             


Ala Pro  Trp Leu Phe Cys Asp  Arg Glu Ser Ser Pro  Ser Glu Ala 
    1235                 1240                 1245             


Ser Thr  Thr Asp Thr Ser Trp  Leu Val Pro Ala Thr  Pro Leu Ala 
    1250                 1255                 1260             


Ser Arg  Ser Arg Asp Cys Ser  Ser Gln Thr Gln Ile  Ser Ser Leu 
    1265                 1270                 1275             


Arg Ser  Gly Leu Ala Val Gln  Ala Val Thr Gln His  Thr Pro Arg 
    1280                 1285                 1290             


Ala Ser  Val Gly Asn Arg Glu  Gly Asn Glu Val Ala  Gln Lys Phe 
    1295                 1300                 1305             


Ser Val  Ile Arg Pro Gln Thr  Pro Pro Pro Gln Thr  Pro Ser Ser 
    1310                 1315                 1320             


Cys Leu  Thr Pro Val Ser Pro  Gly Thr Ser Asp Gly  Arg Arg Gln 
    1325                 1330                 1335             


Gly His  Arg Ser Pro Ser Arg  Pro His Pro Gly Gly  His Pro His 
    1340                 1345                 1350             


Ser Ser  Pro Leu Ala Pro His  Pro Ile Ser Gly Asp  Arg Ala His 
    1355                 1360                 1365             


Phe Ser  Arg Arg Phe Leu Lys  His Ser Pro Pro Gly  Pro Ser Phe 
    1370                 1375                 1380             


Leu Asn  Gln Thr Pro Ala Gly  Glu Val Val Glu Val  Gly Asp Ser 
    1385                 1390                 1395             


Asp Asp  Glu Gln Glu Val Ala  Ser His Gln Ala Asn  Arg Ser Pro 
    1400                 1405                 1410             


Pro Leu  Asp Ser Asp Pro Pro  Ile Pro Ile Asp Asp  Cys Cys Trp 
    1415                 1420                 1425             


His Met  Glu Pro Leu Ser Pro  Ile Pro Ile Asp His  Trp Asn Leu 
    1430                 1435                 1440             


Glu Arg  Thr Gly Pro Leu Ser  Thr Ser Ser Pro Ser  Arg Arg Met 
    1445                 1450                 1455             


Asn Glu  Ala Ala Asp Ser Arg  Asp Cys Arg Ser Pro  Gly Leu Leu 
    1460                 1465                 1470             


Asp Thr  Thr Pro Ile Arg Gly  Ser Cys Thr Thr Gln  Arg Lys Leu 
    1475                 1480                 1485             


Gln Glu  Lys Ser Ser Gly Ala  Gly Ser Leu Gly Asn  Ser Arg Pro 
    1490                 1495                 1500             


Ser Phe  Leu Asn Ser Ala Leu  Trp Asp Val Trp Asp  Gly Glu Glu 
    1505                 1510                 1515             


Gln Arg  Pro Pro Glu Thr Pro  Pro Pro Ala Gln Met  Pro Ser Ala 
    1520                 1525                 1530             


Gly Gly  Ala Gln Lys Pro Glu  Gly Leu Glu Thr Pro  Lys Gly Ala 
    1535                 1540                 1545             


Asn Arg  Lys Lys Asn Leu Pro  Pro Lys Val Pro Ile  Thr Pro Met 
    1550                 1555                 1560             


Pro Gln  Tyr Ser Ile Met Glu  Thr Pro Val Leu Lys  Lys Glu Leu 
    1565                 1570                 1575             


Asp Arg  Phe Gly Val Arg Pro  Leu Pro Lys Arg Gln  Met Val Leu 
    1580                 1585                 1590             


Lys Leu  Lys Glu Ile Phe Gln  Tyr Thr His Gln Thr  Leu Asp Ser 
    1595                 1600                 1605             


Asp Ser  Glu Asp Glu Ser Gln  Ser Ser Gln Pro Leu  Leu Gln Ala 
    1610                 1615                 1620             


Pro His  Cys Gln Thr Leu Ala  Ser Gln Thr Tyr Lys  Pro Ser Arg 
    1625                 1630                 1635             


Ala Gly  Val His Ala Gln Gln  Glu Ala Thr Thr Gly  Pro Gly Ala 
    1640                 1645                 1650             


His Arg  Pro Lys Gly Pro Ala  Lys Thr Lys Gly Pro  Arg His Gln 
    1655                 1660                 1665             


Arg Lys  His His Glu Ser Ile  Thr Pro Pro Ser Arg  Ser Pro Thr 
    1670                 1675                 1680             


Lys Glu  Ala Pro Pro Gly Leu  Asn Asp Asp Ala Gln  Ile Pro Ala 
    1685                 1690                 1695             


Ser Gln  Glu Ser Val Ala Thr  Ser Val Asp Gly Ser  Asp Ser Ser 
    1700                 1705                 1710             


Leu Ser  Ser Gln Ser Ser Ser  Ser Cys Glu Phe Gly  Ala Ala Phe 
    1715                 1720                 1725             


Glu Ser  Ala Gly Glu Glu Glu  Gly Glu Gly Glu Val  Ser Ala Ser 
    1730                 1735                 1740             


Gln Ala  Ala Val Gln Ala Ala  Asp Thr Asp Glu Ala  Leu Arg Cys 
    1745                 1750                 1755             


Tyr Ile  Arg Ser Lys Pro Ala  Leu Tyr Gln Lys Val  Leu Leu Tyr 
    1760                 1765                 1770             


Gln Pro  Phe Glu Leu Arg Glu  Leu Gln Ala Glu Leu  Arg Gln Asn 
    1775                 1780                 1785             


Gly Leu  Arg Val Ser Ser Arg  Arg Leu Leu Asp Phe  Leu Asp Thr 
    1790                 1795                 1800             


His Cys  Ile Thr Phe Thr Thr  Ala Ala Thr Arg Arg  Glu Lys Leu 
    1805                 1810                 1815             


Gln Gly  Arg Arg Arg Gln Pro  Arg Gly Lys Lys Lys  Val Glu Arg 
    1820                 1825                 1830             


Asn 
    


<210>  68
<211>  1522
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Phe Ser Phe Arg Cys Leu Asp Glu Ala Glu Lys Thr Leu Arg Pro 
1               5                   10                  15      


Ser Val Pro Gln Ile Pro Glu Cys Pro Ile Cys Gly Lys Pro Phe Leu 
            20                  25                  30          


Thr Leu Lys Ser Arg Thr Ser His Leu Lys Gln Cys Ala Val Lys Met 
        35                  40                  45              


Glu Val Gly Pro Gln Leu Leu Leu Gln Ala Val Arg Leu Gln Thr Ala 
    50                  55                  60                  


Gln Pro Glu Gly Ser Ser Ser Pro Pro Met Phe Ser Phe Ser Asp His 
65                  70                  75                  80  


Ser Arg Gly Leu Lys Arg Arg Gly Pro Thr Ser Lys Lys Glu Pro Arg 
                85                  90                  95      


Lys Arg Arg Lys Val Asp Glu Ala Pro Ser Glu Asp Leu Leu Val Ala 
            100                 105                 110         


Met Ala Leu Ser Arg Ser Glu Met Glu Pro Gly Ala Ala Val Pro Ala 
        115                 120                 125             


Leu Arg Leu Glu Ser Ala Phe Ser Glu Arg Ile Arg Pro Glu Ala Glu 
    130                 135                 140                 


Asn Lys Ser Arg Lys Lys Lys Pro Pro Val Ser Pro Pro Leu Leu Leu 
145                 150                 155                 160 


Val Gln Asp Ser Glu Thr Thr Gly Arg Gln Ile Glu Asp Arg Val Ala 
                165                 170                 175     


Leu Leu Leu Ser Glu Glu Val Glu Leu Ser Ser Thr Pro Pro Leu Pro 
            180                 185                 190         


Ala Ser Arg Ile Leu Lys Glu Gly Trp Glu Arg Ala Gly Gln Cys Pro 
        195                 200                 205             


Pro Pro Pro Glu Arg Lys Gln Ser Phe Leu Trp Glu Gly Ser Ala Leu 
    210                 215                 220                 


Thr Gly Ala Trp Ala Met Glu Asp Phe Tyr Thr Ala Arg Leu Val Pro 
225                 230                 235                 240 


Pro Leu Val Pro Gln Arg Pro Ala Gln Gly Leu Met Gln Glu Pro Val 
                245                 250                 255     


Pro Pro Leu Val Pro Pro Glu His Ser Glu Leu Ser Glu Arg Arg Ser 
            260                 265                 270         


Pro Ala Leu His Gly Thr Pro Thr Ala Gly Cys Gly Ser Arg Gly Pro 
        275                 280                 285             


Ser Pro Ser Ala Ser Gln Arg Glu His Gln Ala Leu Gln Asp Leu Val 
    290                 295                 300                 


Asp Leu Ala Arg Glu Gly Leu Ser Ala Ser Pro Trp Pro Gly Ser Gly 
305                 310                 315                 320 


Gly Leu Ala Gly Ser Glu Gly Thr Ala Gly Leu Asp Val Val Pro Gly 
                325                 330                 335     


Gly Leu Pro Leu Thr Gly Phe Val Val Pro Ser Gln Asp Lys His Pro 
            340                 345                 350         


Asp Arg Gly Gly Arg Thr Leu Leu Ser Leu Gly Leu Leu Val Ala Asp 
        355                 360                 365             


Phe Gly Ala Met Val Asn Asn Pro His Leu Ser Asp Val Gln Phe Gln 
    370                 375                 380                 


Thr Asp Ser Gly Glu Val Leu Tyr Ala His Lys Phe Val Leu Tyr Ala 
385                 390                 395                 400 


Arg Cys Pro Leu Leu Ile Gln Tyr Val Asn Asn Glu Gly Phe Ser Ala 
                405                 410                 415     


Val Glu Asp Gly Val Leu Thr Gln Arg Val Leu Leu Gly Asp Val Ser 
            420                 425                 430         


Thr Glu Ala Ala Arg Thr Phe Leu His Tyr Leu Tyr Thr Ala Asp Thr 
        435                 440                 445             


Gly Leu Pro Pro Gly Leu Ser Ser Glu Leu Ser Ser Leu Ala His Arg 
    450                 455                 460                 


Phe Gly Val Ser Glu Leu Val His Leu Cys Glu Gln Val Pro Ile Ala 
465                 470                 475                 480 


Thr Asp Ser Glu Gly Lys Pro Trp Glu Glu Lys Glu Ala Glu Asn Cys 
                485                 490                 495     


Glu Ser Arg Ala Glu Asn Phe Gln Glu Leu Leu Arg Ser Met Trp Ala 
            500                 505                 510         


Asp Glu Glu Glu Glu Ala Glu Thr Leu Leu Lys Ser Lys Asp His Glu 
        515                 520                 525             


Glu Asp Gln Glu Asn Val Asn Glu Ala Glu Met Glu Glu Ile Tyr Glu 
    530                 535                 540                 


Phe Ala Ala Thr Gln Arg Lys Leu Leu Gln Glu Glu Arg Ala Ala Gly 
545                 550                 555                 560 


Ala Gly Glu Asp Ala Asp Trp Leu Glu Gly Gly Ser Pro Val Ser Gly 
                565                 570                 575     


Gln Leu Leu Ala Gly Val Gln Val Gln Lys Gln Trp Asp Lys Val Glu 
            580                 585                 590         


Glu Met Glu Pro Leu Glu Pro Gly Arg Asp Glu Ala Ala Thr Thr Trp 
        595                 600                 605             


Glu Lys Met Gly Gln Cys Ala Leu Pro Pro Pro Gln Gly Gln His Ser 
    610                 615                 620                 


Gly Ala Arg Gly Ala Glu Ala Pro Glu Gln Glu Ala Pro Glu Glu Ala 
625                 630                 635                 640 


Leu Gly His Ser Ser Cys Ser Ser Pro Ser Arg Asp Cys Gln Ala Glu 
                645                 650                 655     


Arg Lys Glu Gly Ser Leu Pro His Ser Asp Asp Ala Gly Asp Tyr Glu 
            660                 665                 670         


Gln Leu Phe Ser Ser Thr Gln Gly Glu Ile Ser Glu Pro Ser Gln Ile 
        675                 680                 685             


Thr Ser Glu Pro Glu Glu Gln Ser Gly Ala Val Arg Glu Arg Gly Leu 
    690                 695                 700                 


Glu Val Ser His Arg Leu Ala Pro Trp Gln Ala Ser Pro Pro His Pro 
705                 710                 715                 720 


Cys Arg Phe Leu Leu Gly Pro Pro Gln Gly Gly Ser Pro Arg Gly Ser 
                725                 730                 735     


His His Thr Ser Gly Ser Ser Leu Ser Thr Pro Arg Ser Arg Gly Gly 
            740                 745                 750         


Thr Ser Gln Val Gly Ser Pro Thr Leu Leu Ser Pro Ala Val Pro Ser 
        755                 760                 765             


Lys Gln Lys Arg Asp Arg Ser Ile Leu Thr Leu Ser Lys Glu Pro Gly 
    770                 775                 780                 


His Gln Lys Gly Lys Glu Arg Arg Ser Val Leu Glu Cys Arg Asn Lys 
785                 790                 795                 800 


Gly Val Leu Met Phe Pro Glu Lys Ser Pro Ser Ile Asp Leu Thr Gln 
                805                 810                 815     


Ser Asn Pro Asp His Ser Ser Ser Arg Ser Gln Lys Ser Ser Ser Lys 
            820                 825                 830         


Leu Asn Glu Glu Asp Glu Val Ile Leu Leu Leu Asp Ser Asp Glu Glu 
        835                 840                 845             


Leu Glu Leu Glu Gln Thr Lys Met Lys Ser Ile Ser Ser Asp Pro Leu 
    850                 855                 860                 


Glu Glu Lys Lys Ala Leu Glu Ile Ser Pro Arg Ser Cys Glu Leu Phe 
865                 870                 875                 880 


Ser Ile Ile Asp Val Asp Ala Asp Gln Glu Pro Ser Gln Ser Pro Pro 
                885                 890                 895     


Arg Ser Glu Ala Val Leu Gln Gln Glu Asp Glu Gly Ala Leu Pro Glu 
            900                 905                 910         


Asn Arg Gly Ser Leu Gly Arg Arg Gly Ala Pro Trp Leu Phe Cys Asp 
        915                 920                 925             


Arg Glu Ser Ser Pro Ser Glu Ala Ser Thr Thr Asp Thr Ser Trp Leu 
    930                 935                 940                 


Val Pro Ala Thr Pro Leu Ala Ser Arg Ser Arg Asp Cys Ser Ser Gln 
945                 950                 955                 960 


Thr Gln Ile Ser Ser Leu Arg Ser Gly Leu Ala Val Gln Ala Val Thr 
                965                 970                 975     


Gln His Thr Pro Arg Ala Ser Val Gly Asn Arg Glu Gly Asn Glu Val 
            980                 985                 990         


Ala Gln Lys Phe Ser Val Ile Arg  Pro Gln Thr Pro Pro  Pro Gln Thr 
        995                 1000                 1005             


Pro Ser  Ser Cys Leu Thr Pro  Val Ser Pro Gly Thr  Ser Asp Gly 
    1010                 1015                 1020             


Arg Arg  Gln Gly His Arg Ser  Pro Ser Arg Pro His  Pro Gly Gly 
    1025                 1030                 1035             


His Pro  His Ser Ser Pro Leu  Ala Pro His Pro Ile  Ser Gly Asp 
    1040                 1045                 1050             


Arg Ala  His Phe Ser Arg Arg  Phe Leu Lys His Ser  Pro Pro Gly 
    1055                 1060                 1065             


Pro Ser  Phe Leu Asn Gln Thr  Pro Ala Gly Glu Val  Val Glu Val 
    1070                 1075                 1080             


Gly Asp  Ser Asp Asp Glu Gln  Glu Val Ala Ser His  Gln Ala Asn 
    1085                 1090                 1095             


Arg Ser  Pro Pro Leu Asp Ser  Asp Pro Pro Ile Pro  Ile Asp Asp 
    1100                 1105                 1110             


Cys Cys  Trp His Met Glu Pro  Leu Ser Pro Ile Pro  Ile Asp His 
    1115                 1120                 1125             


Trp Asn  Leu Glu Arg Thr Gly  Pro Leu Ser Thr Ser  Ser Pro Ser 
    1130                 1135                 1140             


Arg Arg  Met Asn Glu Ala Ala  Asp Ser Arg Asp Cys  Arg Ser Pro 
    1145                 1150                 1155             


Gly Leu  Leu Asp Thr Thr Pro  Ile Arg Gly Ser Cys  Thr Thr Gln 
    1160                 1165                 1170             


Arg Lys  Leu Gln Glu Lys Ser  Ser Gly Ala Gly Ser  Leu Gly Asn 
    1175                 1180                 1185             


Ser Arg  Pro Ser Phe Leu Asn  Ser Ala Leu Trp Asp  Val Trp Asp 
    1190                 1195                 1200             


Gly Glu  Glu Gln Arg Pro Pro  Glu Thr Pro Pro Pro  Ala Gln Met 
    1205                 1210                 1215             


Pro Ser  Ala Gly Gly Ala Gln  Lys Pro Glu Gly Leu  Glu Thr Pro 
    1220                 1225                 1230             


Lys Gly  Ala Asn Arg Lys Lys  Asn Leu Pro Pro Lys  Val Pro Ile 
    1235                 1240                 1245             


Thr Pro  Met Pro Gln Tyr Ser  Ile Met Glu Thr Pro  Val Leu Lys 
    1250                 1255                 1260             


Lys Glu  Leu Asp Arg Phe Gly  Val Arg Pro Leu Pro  Lys Arg Gln 
    1265                 1270                 1275             


Met Val  Leu Lys Leu Lys Glu  Ile Phe Gln Tyr Thr  His Gln Thr 
    1280                 1285                 1290             


Leu Asp  Ser Asp Ser Glu Asp  Glu Ser Gln Ser Ser  Gln Pro Leu 
    1295                 1300                 1305             


Leu Gln  Ala Pro His Cys Gln  Thr Leu Ala Ser Gln  Thr Tyr Lys 
    1310                 1315                 1320             


Pro Ser  Arg Ala Gly Val His  Ala Gln Gln Glu Ala  Thr Thr Gly 
    1325                 1330                 1335             


Pro Gly  Ala His Arg Pro Lys  Gly Pro Ala Lys Thr  Lys Gly Pro 
    1340                 1345                 1350             


Arg His  Gln Arg Lys His His  Glu Ser Ile Thr Pro  Pro Ser Arg 
    1355                 1360                 1365             


Ser Pro  Thr Lys Glu Ala Pro  Pro Gly Leu Asn Asp  Asp Ala Gln 
    1370                 1375                 1380             


Ile Pro  Ala Ser Gln Glu Ser  Val Ala Thr Ser Val  Asp Gly Ser 
    1385                 1390                 1395             


Asp Ser  Ser Leu Ser Ser Gln  Ser Ser Ser Ser Cys  Glu Phe Gly 
    1400                 1405                 1410             


Ala Ala  Phe Glu Ser Ala Gly  Glu Glu Glu Gly Glu  Gly Glu Val 
    1415                 1420                 1425             


Ser Ala  Ser Gln Ala Ala Val  Gln Ala Ala Asp Thr  Asp Glu Ala 
    1430                 1435                 1440             


Leu Arg  Cys Tyr Ile Arg Ser  Lys Pro Ala Leu Tyr  Gln Lys Val 
    1445                 1450                 1455             


Leu Leu  Tyr Gln Pro Phe Glu  Leu Arg Glu Leu Gln  Ala Glu Leu 
    1460                 1465                 1470             


Arg Gln  Asn Gly Leu Arg Val  Ser Ser Arg Arg Leu  Leu Asp Phe 
    1475                 1480                 1485             


Leu Asp  Thr His Cys Ile Thr  Phe Thr Thr Ala Ala  Thr Arg Arg 
    1490                 1495                 1500             


Glu Lys  Leu Gln Gly Arg Arg  Arg Gln Pro Arg Gly  Lys Lys Lys 
    1505                 1510                 1515             


Val Glu  Arg Asn 
    1520         


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized single guide RNA sequence

<400>  69
catgaccacg gcggcaataa                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized single guide RNA sequence

<400>  70
aaagaccttt attgccgccg                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized single guide RNA sequence

<400>  71
cctttcctga agggaaccag                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized single guide RNA sequence

<400>  72
attatgctga ggatttggaa                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized single guide RNA sequence

<400>  73
agtctcgaag atatgactcc                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized single guide RNA sequence

<400>  74
cgaagataac gcggatacct                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized single guide RNA sequence

<400>  75
gtacgtcggt ataactcctc                                                   20


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized short hairpin RNA

<400>  76
caacaagatg aagagcacca a                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized short hairpin RNA

<400>  77
gacttcatga aactctataa t                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized short hairpin RNA

<400>  78
aggacgagag gaacgtattt a                                                 21


