
                                SEQUENCE LISTING

<110> ADAGENE PTE. LTD.

<120> COMBINATION THERAPY COMPRISING ANTI-CD137 ANTIBODIES

<130> 69540-20007.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 63/043,042
<151> 2020-06-23

<160> 44

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 255
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu
 1               5                  10                  15      
Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro
            20                  25                  30          
Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys
        35                  40                  45              
Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile
    50                  55                  60                  
Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser
65                  70                  75                  80  
Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly
                85                  90                  95      
Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu
            100                 105                 110         
Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln
        115                 120                 125             
Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys
    130                 135                 140                 
Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro
145                 150                 155                 160 
Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala
                165                 170                 175     
Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu
            180                 185                 190         
Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu
        195                 200                 205             
Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
    210                 215                 220                 
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
225                 230                 235                 240 
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
                245                 250                 255 


<210> 2
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Phe Ser Leu Ser Thr Gly Gly Val Gly Val Gly Trp Ile
 1               5                  10              


<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
 1               5                  10                  15  


<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Arg Ala Ser Gln Ser Ile Gly Ser Tyr Leu Ala
 1               5                  10      


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Asp Ala Ser Asn Leu Glu Thr Gly Val
 1               5                  


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
 1               5                  10  


<210> 8
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Gly
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 10
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Gly
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
        435                 440                 445             
Gly Lys
    450 


<210> 11
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Tyr Ser Ile Thr Ser Gly His Tyr Trp Ala Trp Ile
 1               5                  10          


<210> 13
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser
 1               5                  10                  15      
Val Lys Gly Arg Phe
            20      


<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Ala Arg Gly Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr
 1               5                  10                  15  


<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Arg Ala Ser Gln Gly Ile Gly Ser Phe Leu Ala
 1               5                  10      


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Asp Ala Ser Asn Leu Glu Thr Gly Val
 1               5                  


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
 1               5                  10  


<210> 18
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          
His Tyr Trp Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 19
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Phe
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 20
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          
His Tyr Trp Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
        435                 440                 445             
Gly Lys
    450 


<210> 21
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Phe
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Phe Ser Leu Ser Thr Ser Gly Val Gly Val Gly Trp Ile
 1               5                  10              


<210> 23
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 24
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Ala Arg Gly Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr
 1               5                  10                  15  


<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Arg Ala Ser Gln Ser Val Ser Pro Tyr Leu Ala
 1               5                  10      


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Asp Ala Ser Ser Leu Glu Ser Gly Val
 1               5                  


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Tyr Cys Gln Gln Gly Tyr Ser Leu Trp Thr
 1               5                  10  


<210> 28
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 29
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Pro Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 30
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
        435                 440                 445             
Gly Lys
    450 


<210> 31
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Pro Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = F or Y

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = S or T

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = G, N, or S

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = A, G, or W

<400> 32
Xaa Thr Phe Xaa Xaa Tyr Xaa Ile His Trp Val
 1               5                  10      


<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = S or T

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = H or Y

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = H or Y

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = A, D, G, N, S, or T

<400> 33
Tyr Ser Ile Xaa Ser Gly Xaa Xaa Trp Xaa Trp Ile
 1               5                  10          


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = G or S

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = A or G

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = A, G, S, or T

<400> 34
Phe Ser Leu Ser Thr Xaa Gly Val Xaa Val Xaa Trp Ile
 1               5                  10              


<210> 35
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = A, D, or Y

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = D or G

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = R, S, or Y

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = P or T

<400> 35
Leu Ala Leu Ile Asp Trp Xaa Xaa Asp Lys Xaa Tyr Ser Xaa Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 36
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = D or E

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = N or S

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = N or S

<400> 36
Ile Gly Xaa Ile Tyr His Ser Gly Xaa Thr Tyr Tyr Xaa Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Val
            20  


<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = A, G, S, V, or Y

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = A, D, S, or Y

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = D, G, or S

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = S or T

<400> 37
Val Ser Xaa Ile Ser Gly Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser
 1               5                  10                  15      
Val Lys Gly Arg Phe
            20      


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = E or G

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = E or S

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = D or T

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = A, T, or V

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = A, I, L, T, or V

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = A, D, or G

<400> 38
Ala Arg Xaa Gly Xaa Xaa Xaa Val Xaa Gly Asp Trp Phe Xaa Tyr
 1               5                  10                  15  


<210> 39
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Q or R

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = D, G, or S

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = I or V

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = G, R, S, or T

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = P, R, S, or T

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = A, D, F, S, V, or Y

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = L or V

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = A, G, or N

<400> 39
Xaa Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10      


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = A or D

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = N, S, or T

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = L or R

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = A, E, or Q

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = S or T

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = I or V

<400> 40
Xaa Ala Ser Xaa Xaa Xaa Xaa Gly Xaa
 1               5                  


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = A, G, S, or Y

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Q, S, or Y

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = I, L, T, or Y

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = I, S, V, or W

<400> 41
Tyr Cys Gln Gln Xaa Tyr Xaa Xaa Xaa Thr
 1               5                  10  


<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = E or Q

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = P, S, or Y

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = D, L, S, T, or Y

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = D, E, H, S, or T

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = D, L, T, or W

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = L, P, R, or V

<400> 42
Tyr Cys Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Thr
 1               5                  10      


<210> 43
<211> 153
<212> PRT
<213> Homo sapiens

<400> 43
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr
145                 150             


<210> 44
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Met Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu
 1               5                  10                  15      
His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr
            20                  25                  30          
Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro
        35                  40                  45              
Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu
    50                  55                  60                  
Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His
65                  70                  75                  80  
Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu
                85                  90                  95      
Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr
            100                 105                 110         
Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser
        115                 120                 125             
Ile Ile Ser Thr Leu Thr
    130                 

