                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> TUNNELING NANOTUBE CELLS AND METHODS OF USE THEREOF FOR DELIVERY 
      OF BIOMOLECULES

<130> 29539-0407WO1

<140> PCT/US2021/038588
<141> 2021-06-23

<150> 63/042,909
<151> 2020-06-23

<160> 41    

<170> PatentIn version 3.5

<210> 1
<211> 1710
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1610                 1615                 1620             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1625                 1630                 1635             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1640                 1645                 1650             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1655                 1660                 1665             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1670                 1675                 1680             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1685                 1690                 1695             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1700                 1705                 1710 


<210> 2
<211> 198
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210> 3
<211> 191
<212> PRT
<213> Homo sapiens

<400> 3
Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly 
1               5                   10                  15      


Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Ser Ala 
            20                  25                  30          


Thr Ser Phe Ser Leu Asp Phe Gly Tyr Leu Arg Asn Lys Asn Gly Cys 
        35                  40                  45              


His Val Glu Leu Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp 
    50                  55                  60                  


Pro Gly Arg Cys Tyr Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys 
65                  70                  75                  80  


Tyr Asp Cys Ala Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn 
                85                  90                  95      


Leu Ser Leu Arg Ile Phe Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg 
            100                 105                 110         


Lys Ala Glu Pro Glu Gly Leu Arg Arg Leu His Arg Ala Gly Val Gln 
        115                 120                 125             


Ile Ala Ile Met Thr Phe Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe 
    130                 135                 140                 


Val Glu Asn His Glu Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu 
145                 150                 155                 160 


Asn Ser Val Arg Leu Ser Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu 
                165                 170                 175     


Tyr Glu Val Asp Asp Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu 
            180                 185                 190     


<210> 4
<211> 175
<212> PRT
<213> Homo sapiens

<400> 4
Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg 
1               5                   10                  15      


His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Ser Ala Thr 
            20                  25                  30          


Ser Phe Ser Leu Asp Phe Gly Tyr Leu Arg Asn Lys Asn Gly Cys His 
        35                  40                  45              


Val Glu Leu Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro 
    50                  55                  60                  


Gly Arg Cys Tyr Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr 
65                  70                  75                  80  


Asp Cys Ala Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu 
                85                  90                  95      


Ser Leu Arg Ile Phe Thr Ala Arg Leu Tyr Phe Cys Glu Asp Arg Lys 
            100                 105                 110         


Ala Glu Pro Glu Gly Leu Arg Arg Leu His Arg Ala Gly Val Gln Ile 
        115                 120                 125             


Ala Ile Met Thr Phe Lys Asp Tyr Phe Tyr Cys Trp Asn Thr Phe Val 
    130                 135                 140                 


Glu Asn His Glu Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu Asn 
145                 150                 155                 160 


Ser Val Arg Leu Ser Arg Gln Leu Arg Arg Ile Leu Leu Pro Leu 
                165                 170                 175 


<210> 5
<211> 229
<212> PRT
<213> Rattus norvegicus

<400> 5
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210> 6
<211> 397
<212> PRT
<213> Mus musculus

<400> 6
Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Gly Tyr Ala Lys Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile 
            100                 105                 110         


Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Arg Met Asp Pro Leu Ser Glu Glu Glu Phe 
        195                 200                 205             


Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr His 
    210                 215                 220                 


Arg Met Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly Gln 
225                 230                 235                 240 


Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His Ala 
                245                 250                 255     


Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln Val 
            260                 265                 270         


Thr Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala Trp 
        275                 280                 285             


Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His Ile 
    290                 295                 300                 


Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys Gly 
305                 310                 315                 320 


Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp Leu 
                325                 330                 335     


Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg Pro 
            340                 345                 350         


Phe Arg Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln Arg 
        355                 360                 365             


Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val Asn 
    370                 375                 380                 


Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser Asn 
385                 390                 395         


<210> 7
<211> 199
<212> PRT
<213> Mus musculus

<400> 7
Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Gly Tyr Ala Lys Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile 
            100                 105                 110         


Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Arg 
        195                 


<210> 8
<211> 199
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210> 9
<211> 384
<212> PRT
<213> Homo sapiens

<400> 9
Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210> 10
<211> 186
<212> PRT
<213> Homo sapiens

<400> 10
Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val Arg Gly 
1               5                   10                  15      


Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His Asn Asp 
            20                  25                  30          


Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn Gln Ala 
        35                  40                  45              


Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu Cys Phe 
    50                  55                  60                  


Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp Tyr Arg 
65                  70                  75                  80  


Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu 
                85                  90                  95      


Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys Ile Phe 
            100                 105                 110         


Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys Gln Glu Gly Leu Arg 
        115                 120                 125             


Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr Tyr Ser Glu 
    130                 135                 140                 


Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe 
145                 150                 155                 160 


Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser Gly Arg 
                165                 170                 175     


Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
            180                 185     


<210> 11
<211> 200
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Leu Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Leu Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu 
        35                  40                  45              


Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Ser Ser Cys Ala Trp Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Asp His Leu Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Cys Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Phe Pro Lys Phe Ala Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 
145                 150                 155                 160 


Lys Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ile Pro Gly Val Arg Ala Gln Gly Arg Tyr Met 
            180                 185                 190         


Asp Ile Leu Cys Asp Ala Glu Val 
        195                 200 


<210> 12
<211> 373
<212> PRT
<213> Homo sapiens

<400> 12
Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 
    50                  55                  60                  


His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys 
                85                  90                  95      


Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn 
            100                 105                 110         


Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg 
        115                 120                 125             


Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val 
    130                 135                 140                 


Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 
                165                 170                 175     


Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 
            180                 185                 190         


Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg 
        195                 200                 205             


Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val 
    210                 215                 220                 


Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn 
225                 230                 235                 240 


Gln Val Asp Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser 
                245                 250                 255     


Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr 
            260                 265                 270         


Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 
        275                 280                 285             


Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 
    290                 295                 300                 


Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 
305                 310                 315                 320 


Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe 
                325                 330                 335     


Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys 
            340                 345                 350         


Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu 
        355                 360                 365             


Gln Glu Ile Leu Glu 
    370             


<210> 13
<211> 189
<212> PRT
<213> Homo sapiens

<400> 13
Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met Tyr Pro His Ile Phe 
1               5                   10                  15      


Tyr Phe His Phe Lys Asn Leu Arg Lys Ala Tyr Gly Arg Asn Glu Ser 
            20                  25                  30          


Trp Leu Cys Phe Thr Met Glu Val Val Lys His His Ser Pro Val Ser 
        35                  40                  45              


Trp Lys Arg Gly Val Phe Arg Asn Gln Val Asp Pro Glu Thr His Cys 
    50                  55                  60                  


His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu Ser 
65                  70                  75                  80  


Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr Ser Trp Ser Pro Cys 
                85                  90                  95      


Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser Asn 
            100                 105                 110         


Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Trp Asp Thr 
        115                 120                 125             


Asp Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Ala Ser Val 
    130                 135                 140                 


Glu Ile Met Gly Tyr Lys Asp Phe Lys Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Asn Asp Asp Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Tyr Asn 
                165                 170                 175     


Phe Leu Phe Leu Asp Ser Lys Leu Gln Glu Ile Leu Glu 
            180                 185                 


<210> 14
<211> 383
<212> PRT
<213> Escherichia coli

<400> 14
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp 
    370                 375                 380             


<210> 15
<211> 1226
<212> PRT
<213> Homo sapiens

<400> 15
Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Gly Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Val Thr Pro Val Thr Gly Ala Ser Leu Arg 
                805                 810                 815     


Arg Thr Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln Pro Lys Thr 
            820                 825                 830         


Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala Met Leu Ser 
        835                 840                 845             


His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro Ser Leu Leu 
    850                 855                 860                 


Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
865                 870                 875                 880 


Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly 
                885                 890                 895     


Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu 
            900                 905                 910         


Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
        915                 920                 925             


Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
    930                 935                 940                 


Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr 
945                 950                 955                 960 


Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
                965                 970                 975     


Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe 
            980                 985                 990         


Glu Asn Pro Lys Gln Gly Lys Leu  Arg Thr Lys Val Glu  Asn Gly Glu 
        995                 1000                 1005             


Gly Thr  Ile Pro Val Glu Ser  Ser Asp Ile Val Pro  Thr Trp Asp 
    1010                 1015                 1020             


Gly Ile  Arg Leu Gly Glu Arg  Leu Arg Thr Met Ser  Cys Ser Asp 
    1025                 1030                 1035             


Lys Ile  Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
    1040                 1045                 1050             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1070                 1075                 1080             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1085                 1090                 1095             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1100                 1105                 1110             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1115                 1120                 1125             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1130                 1135                 1140             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1145                 1150                 1155             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1160                 1165                 1170             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1175                 1180                 1185             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1190                 1195                 1200             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1205                 1210                 1215             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1220                 1225     


<210> 16
<211> 701
<212> PRT
<213> Homo sapiens

<400> 16
Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu 
465                 470                 475                 480 


Arg Thr Lys Ile Glu Ser Gly Gln Gly Thr Ile Pro Val Arg Ser Asn 
                485                 490                 495     


Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu 
            500                 505                 510         


Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile 
        515                 520                 525             


Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser 
    530                 535                 540                 


Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met 
545                 550                 555                 560 


Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu 
                565                 570                 575     


Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro 
            580                 585                 590         


Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala 
        595                 600                 605             


Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala 
    610                 615                 620                 


Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His 
625                 630                 635                 640 


Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn 
                645                 650                 655     


Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys 
            660                 665                 670         


Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val 
        675                 680                 685             


Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro 
    690                 695                 700     


<210> 17
<211> 1419
<212> PRT
<213> Streptococcus pyogenes

<400> 17
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Ser  Gly Gly Gly Gly Ser  Gly Lys Arg Thr Ala  Asp Gly Ser 
    1370                 1375                 1380             


Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val Ser Ser  Gly Gly Asp 
    1385                 1390                 1395             


Tyr Lys  Asp His Asp Gly Asp  Tyr Lys Asp His Asp  Ile Asp Tyr 
    1400                 1405                 1410             


Lys Asp  Asp Asp Asp Lys 
    1415                 


<210> 18
<211> 1053
<212> PRT
<213> Staphylococcus aureus

<400> 18
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 19
<211> 984
<212> PRT
<213> Campylobacter jejuni

<400> 19
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 20
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 20
Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 21
<211> 1307
<212> PRT
<213> Acidaminococcus sp.

<400> 21
Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210> 22
<211> 1228
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Lachnospiraceae bacterium sequence

<400> 22
Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210> 23
<211> 1389
<212> PRT
<213> Leptotrichia shahii

<400> 23
Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Lys Asp Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Leu 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Lys Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Ile Leu Asn Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Arg Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ile Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro 
        675                 680                 685             


Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Asp Asp Leu Glu Glu Asn Glu Ser Lys Asn Ile Phe Leu Gln Glu Leu 
                725                 730                 735     


Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly Tyr 
    770                 775                 780                 


Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp Lys Thr Ile Val Ile 
            820                 825                 830         


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
        835                 840                 845             


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
                885                 890                 895     


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
            900                 905                 910         


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn 
        915                 920                 925             


Tyr Tyr Glu Asp Ile Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp 
    930                 935                 940                 


Ile Asn Gly Cys Asp Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile 
945                 950                 955                 960 


Phe Asp Asp Glu Thr Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu 
                965                 970                 975     


Gln Asp Glu Gln Arg Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys 
            980                 985                 990         


Lys Lys Val Asp Gln Tyr Ile Lys  Asp Lys Asp Gln Glu  Ile Lys Ser 
        995                 1000                 1005             


Lys Ile  Leu Cys Arg Ile Ile  Phe Asn Ser Asp Phe  Leu Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Glu Asp Met  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Asn Lys Phe Gln Glu  Ile Tyr Tyr Pro Lys  Glu Arg Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Asn Asp Ile 
    1070                 1075                 1080             


Lys Met  Ala Asp Ala Lys Phe  Leu Phe Asn Ile Asp  Gly Lys Asn 
    1085                 1090                 1095             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1100                 1105                 1110             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys 
    1115                 1120                 1125             


Tyr Ile  Lys Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1130                 1135                 1140             


Ile Gln  Asn Lys Asn Tyr Lys  Ser Phe Glu Lys Asp  Tyr Asn Arg 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Glu  Leu Lys Lys 
    1325                 1330                 1335             


Lys Phe  Lys Leu Ile Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met 
    1340                 1345                 1350             


Lys Pro  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu 
    1370                 1375                 1380             


Asn Thr  Asn Asp Thr Leu 
    1385                 


<210> 24
<211> 1152
<212> PRT
<213> Leptotrichia wadei

<400> 24
Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Ile Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Gly Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Tyr Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Glu Asp Leu Arg Asn Thr Leu Lys Phe Phe Trp 
                565                 570                 575     


Ser Val Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Val Phe Phe Lys Ile Thr Asn Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly His Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Glu 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Ile Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Ser Asn Asn Asn Asn Asp Asn Asn Asp Ile 
    690                 695                 700                 


Phe Ser Lys Ile Lys Ile Lys Lys Asp Asn Lys Glu Lys Tyr Asp Lys 
705                 710                 715                 720 


Ile Leu Lys Asn Tyr Glu Lys His Asn Arg Asn Lys Glu Ile Pro His 
                725                 730                 735     


Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys 
            740                 745                 750         


Tyr Thr Glu Asn Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn 
        755                 760                 765             


His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser 
    770                 775                 780                 


Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu 
785                 790                 795                 800 


Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala 
                805                 810                 815     


Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Glu Asn Lys Ile Lys Asp 
            820                 825                 830         


Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly 
        835                 840                 845             


Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly 
    850                 855                 860                 


Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile 
865                 870                 875                 880 


Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu Ile Glu 
                885                 890                 895     


Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys Tyr Ala Arg Pro 
            900                 905                 910         


Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys Glu Tyr Glu Lys 
        915                 920                 925             


Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu 
    930                 935                 940                 


Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His 
945                 950                 955                 960 


Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg 
                965                 970                 975     


Leu Lys Gly Glu Phe Pro Glu Asn His Tyr Ile Glu Glu Ile Phe Asn 
            980                 985                 990         


Phe Asp Asn Ser Lys Asn Val Lys  Tyr Lys Ser Gly Gln  Ile Val Glu 
        995                 1000                 1005             


Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr Lys Asp  Asn Val Glu 
    1010                 1015                 1020             


Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val Lys Lys  Leu Lys Gln 
    1025                 1030                 1035             


Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr Ile Ala  His Phe Asn 
    1040                 1045                 1050             


Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu Glu Val  Leu Glu Asn 
    1055                 1060                 1065             


Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Ile 
    1070                 1075                 1080             


Met Lys  Ser Ile Val Asp Ile  Leu Lys Glu Tyr Gly  Phe Val Ala 
    1085                 1090                 1095             


Thr Phe  Lys Ile Gly Ala Asp  Lys Lys Ile Glu Ile  Gln Thr Leu 
    1100                 1105                 1110             


Glu Ser  Glu Lys Ile Val His  Leu Lys Asn Leu Lys  Lys Lys Lys 
    1115                 1120                 1125             


Leu Met  Thr Asp Arg Asn Ser  Glu Glu Leu Cys Glu  Leu Val Lys 
    1130                 1135                 1140             


Val Met  Phe Glu Tyr Lys Ala  Leu Glu 
    1145                 1150         


<210> 25
<211> 654
<212> PRT
<213> Homo sapiens

<400> 25
Met Ser Glu Ala Ser Ser Glu Asp Leu Val Pro Pro Leu Glu Ala Gly 
1               5                   10                  15      


Ala Ala Pro Tyr Arg Glu Glu Glu Glu Ala Ala Lys Lys Lys Lys Glu 
            20                  25                  30          


Lys Lys Lys Lys Ser Lys Gly Leu Ala Asn Val Phe Cys Val Phe Thr 
        35                  40                  45              


Lys Gly Lys Lys Lys Lys Gly Gln Pro Ser Ser Ala Glu Pro Glu Asp 
    50                  55                  60                  


Ala Ala Gly Ser Arg Gln Gly Leu Asp Gly Pro Pro Pro Thr Val Glu 
65                  70                  75                  80  


Glu Leu Lys Ala Ala Leu Glu Arg Gly Gln Leu Glu Ala Ala Arg Pro 
                85                  90                  95      


Leu Leu Ala Leu Glu Arg Glu Leu Ala Ala Ala Ala Ala Ala Gly Gly 
            100                 105                 110         


Val Ser Glu Glu Glu Leu Val Arg Arg Gln Ser Lys Val Glu Ala Leu 
        115                 120                 125             


Tyr Glu Leu Leu Arg Asp Gln Val Leu Gly Val Leu Arg Arg Pro Leu 
    130                 135                 140                 


Glu Ala Pro Pro Glu Arg Leu Arg Gln Ala Leu Ala Val Val Ala Glu 
145                 150                 155                 160 


Gln Glu Arg Glu Asp Arg Gln Ala Ala Ala Ala Gly Pro Gly Thr Ser 
                165                 170                 175     


Gly Leu Ala Ala Thr Arg Pro Arg Arg Trp Leu Gln Leu Trp Arg Arg 
            180                 185                 190         


Gly Val Ala Glu Ala Ala Glu Glu Arg Met Gly Gln Arg Pro Ala Ala 
        195                 200                 205             


Gly Ala Glu Val Pro Glu Ser Val Phe Leu His Leu Gly Arg Thr Met 
    210                 215                 220                 


Lys Glu Asp Leu Glu Ala Val Val Glu Arg Leu Lys Pro Leu Phe Pro 
225                 230                 235                 240 


Ala Glu Phe Gly Val Val Ala Ala Tyr Ala Glu Ser Tyr His Gln His 
                245                 250                 255     


Phe Ala Ala His Leu Ala Ala Val Ala Gln Phe Glu Leu Cys Glu Arg 
            260                 265                 270         


Asp Thr Tyr Met Leu Leu Leu Trp Val Gln Asn Leu Tyr Pro Asn Asp 
        275                 280                 285             


Ile Ile Asn Ser Pro Lys Leu Val Gly Glu Leu Gln Gly Met Gly Leu 
    290                 295                 300                 


Gly Ser Leu Leu Pro Pro Arg Gln Ile Arg Leu Leu Glu Ala Thr Phe 
305                 310                 315                 320 


Leu Ser Ser Glu Ala Ala Asn Val Arg Glu Leu Met Asp Arg Ala Leu 
                325                 330                 335     


Glu Leu Glu Ala Arg Arg Trp Ala Glu Asp Val Pro Pro Gln Arg Leu 
            340                 345                 350         


Asp Gly His Cys His Ser Glu Leu Ala Ile Asp Ile Ile Gln Ile Thr 
        355                 360                 365             


Ser Gln Ala Gln Ala Lys Ala Glu Ser Ile Thr Leu Asp Leu Gly Ser 
    370                 375                 380                 


Gln Ile Lys Arg Val Leu Leu Val Glu Leu Pro Ala Phe Leu Arg Ser 
385                 390                 395                 400 


Tyr Gln Arg Ala Phe Asn Glu Phe Leu Glu Arg Gly Lys Gln Leu Thr 
                405                 410                 415     


Asn Tyr Arg Ala Asn Val Ile Ala Asn Ile Asn Asn Cys Leu Ser Phe 
            420                 425                 430         


Arg Met Ser Met Glu Gln Asn Trp Gln Val Pro Gln Asp Thr Leu Ser 
        435                 440                 445             


Leu Leu Leu Gly Pro Leu Gly Glu Leu Lys Ser His Gly Phe Asp Thr 
    450                 455                 460                 


Leu Leu Gln Asn Leu His Glu Asp Leu Lys Pro Leu Phe Lys Arg Phe 
465                 470                 475                 480 


Thr His Thr Arg Trp Ala Ala Pro Val Glu Thr Leu Glu Asn Ile Ile 
                485                 490                 495     


Ala Thr Val Asp Thr Arg Leu Pro Glu Phe Ser Glu Leu Gln Gly Cys 
            500                 505                 510         


Phe Arg Glu Glu Leu Met Glu Ala Leu His Leu His Leu Val Lys Glu 
        515                 520                 525             


Tyr Ile Ile Gln Leu Ser Lys Gly Arg Leu Val Leu Lys Thr Ala Glu 
    530                 535                 540                 


Gln Gln Gln Gln Leu Ala Gly Tyr Ile Leu Ala Asn Ala Asp Thr Ile 
545                 550                 555                 560 


Gln His Phe Cys Thr Gln His Gly Ser Pro Ala Thr Trp Leu Gln Pro 
                565                 570                 575     


Ala Leu Pro Thr Leu Ala Glu Ile Ile Arg Leu Gln Asp Pro Ser Ala 
            580                 585                 590         


Ile Lys Ile Glu Val Ala Thr Tyr Ala Thr Cys Tyr Pro Asp Phe Ser 
        595                 600                 605             


Lys Gly His Leu Ser Ala Ile Leu Ala Ile Lys Gly Asn Leu Ser Asn 
    610                 615                 620                 


Ser Glu Val Lys Arg Ile Arg Ser Ile Leu Asp Val Ser Met Gly Ala 
625                 630                 635                 640 


Gln Glu Pro Ser Arg Pro Leu Phe Ser Leu Ile Lys Val Gly 
                645                 650                 


<210> 26
<211> 650
<212> PRT
<213> Mus musculus

<400> 26
Met Ser Glu Ala Ser Ser Glu Asp Leu Met Pro Ser Pro Glu Ala Pro 
1               5                   10                  15      


Asp Gly Glu Glu Glu Ser Ala Lys Lys Lys Glu Lys Lys Ser Lys Gly 
            20                  25                  30          


Leu Ala Asn Met Phe Ser Val Phe Thr Lys Gly Lys Lys Lys Lys Lys 
        35                  40                  45              


Asp Gln Pro Arg Leu Ser Asp Leu Glu Val Gln Pro Lys Pro Arg Pro 
    50                  55                  60                  


Glu Leu Asp Gly Pro Leu Pro Thr Val Glu Glu Leu Lys Glu Ala Leu 
65                  70                  75                  80  


Glu His Gly Arg Leu Glu Val Ala Trp Gln Val Leu Ala Leu Glu Arg 
                85                  90                  95      


Gln Leu Glu Ala Ala Ala Ala Ala Gly Gly Met Ser Asn Glu Glu Leu 
            100                 105                 110         


Val Trp Arg Gln Ser Lys Val Glu Ala Leu Tyr Val Leu Leu Cys Asp 
        115                 120                 125             


Gln Val Leu Gly Val Leu Arg Arg Pro Leu Glu Ala Ala Pro Glu Arg 
    130                 135                 140                 


Leu Ser Gln Ala Leu Ala Val Val Ser Gln Glu Glu Leu Glu Asp Arg 
145                 150                 155                 160 


Arg Ala Ser Gly Gly Pro Leu Ala Ala Ala Leu Glu Ala Thr Arg Pro 
                165                 170                 175     


Arg Arg Trp Leu Gln Arg Trp Arg Gly Val Val Ala Glu Val Ala Ala 
            180                 185                 190         


Glu Arg Leu Asp Ala Gln Pro Ala Thr Ala Pro Glu Gly Arg Ser Glu 
        195                 200                 205             


Ala Glu Ser Arg Phe Leu His Met Gly Arg Thr Met Lys Glu Asp Leu 
    210                 215                 220                 


Glu Val Val Val Glu Arg Leu Lys Pro Leu Phe Pro Asp Glu Phe Asn 
225                 230                 235                 240 


Val Val Arg Thr Tyr Ala Glu Ser Tyr His Tyr His Phe Ala Ser His 
                245                 250                 255     


Leu Cys Ala Leu Ala Gln Phe Glu Leu Cys Glu Arg Asp Thr Tyr Leu 
            260                 265                 270         


Leu Leu Leu Trp Val Gln Asn Leu Tyr Pro Asn Asp Ile Leu Asn Ser 
        275                 280                 285             


Pro Lys Leu Ala Gln Glu Leu Gln Gly Val Gly Leu Gly Ser Leu Leu 
    290                 295                 300                 


Pro Pro Lys Gln Ile Arg Leu Leu Glu Ala Met Phe Leu Ser Asn Glu 
305                 310                 315                 320 


Val Thr Ser Val Lys Gln Leu Met Ala Arg Ala Leu Glu Leu Glu Ser 
                325                 330                 335     


Gln Arg Trp Thr Gln Asp Val Ala Pro Gln Ser Leu Asp Gly His Cys 
            340                 345                 350         


His Ser Glu Leu Ala Ile Asp Ile Leu Gln Ile Ile Ser Gln Gly Gln 
        355                 360                 365             


Thr Lys Ala Glu Asn Ile Thr Ser Asp Val Gly Met Gln Ile Lys Gln 
    370                 375                 380                 


Leu Leu Leu Val Glu Leu Ala Ala Leu Leu Arg Ser Tyr Gln Arg Ala 
385                 390                 395                 400 


Phe Asp Glu Phe Leu Glu Lys Ser Lys Leu Leu Arg Asn Tyr Arg Val 
                405                 410                 415     


Asn Ile Met Ala Asn Ile Asn Asn Cys Leu Phe Phe Trp Thr Ser Val 
            420                 425                 430         


Glu Gln Lys Trp Gln Ile Ser His Asp Ser Leu Asn Arg Leu Leu Glu 
        435                 440                 445             


Pro Leu Lys Asp Leu Lys Ala His Gly Phe Asp Thr Leu Leu Gln Ser 
    450                 455                 460                 


Leu Phe Leu Asp Leu Lys Pro Leu Phe Lys Lys Phe Thr Gln Thr Arg 
465                 470                 475                 480 


Trp Ala Asn Pro Val Glu Thr Leu Glu Glu Ile Ile Thr Thr Val Ser 
                485                 490                 495     


Ser Ser Leu Pro Glu Phe Ser Glu Leu Gln Asp Cys Phe Arg Glu Glu 
            500                 505                 510         


Leu Met Glu Thr Val His Leu His Leu Val Lys Glu Tyr Ile Ile Arg 
        515                 520                 525             


Leu Cys Lys Arg Arg Leu Val Leu Lys Thr Ala Glu Gln Gln Gln Gln 
    530                 535                 540                 


Leu Ala Arg His Ile Leu Ala Asn Ala Asp Ala Ile Gln Gly Phe Cys 
545                 550                 555                 560 


Thr Glu Asn Gly Ser Thr Ala Thr Trp Leu His Arg Ala Leu Pro Met 
                565                 570                 575     


Ile Ala Glu Ile Ile Arg Leu Gln Asp Ser Ser Ala Ile Lys Ile Glu 
            580                 585                 590         


Val Ala Thr Tyr Ala Thr Trp Tyr Pro Asp Phe Ser Lys Gly His Leu 
        595                 600                 605             


Asn Ala Ile Leu Ala Ile Lys Gly Asn Leu Pro Ser Ser Glu Val Arg 
    610                 615                 620                 


Ser Ile Arg Asn Ile Leu Asp Ile Asn Thr Gly Val Gln Glu Pro Pro 
625                 630                 635                 640 


Arg Pro Leu Phe Ser Leu Ile Lys Val Thr 
                645                 650 


<210> 27
<211> 104
<212> PRT
<213> Homo sapiens

<400> 27
Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp His Leu Leu 
        35                  40                  45              


Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr Ala 
    50                  55                  60                  


Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg 
65                  70                  75                  80  


Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala 
                85                  90                  95      


Cys Ile Ala Glu Asn Lys Pro Thr 
            100                 


<210> 28
<211> 97
<212> PRT
<213> Homo sapiens

<400> 28
Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp Ala Gln Gly 
        35                  40                  45              


Ser Ser Glu Gln Glu Leu His Tyr Ala Ser Leu Gln Arg Leu Pro Val 
    50                  55                  60                  


Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg Gly Thr 
65                  70                  75                  80  


Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn Lys Pro 
                85                  90                  95      


Thr 
    


<210> 29
<211> 206
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Ala Asn Lys Pro Lys Gly Gln Asn Ser Leu Ala Leu His Lys 
1               5                   10                  15      


Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
            20                  25                  30          


Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
        35                  40                  45              


Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
    50                  55                  60                  


Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
65                  70                  75                  80  


Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Cys Val Phe Ser Ile Thr 
                85                  90                  95      


Glu Met Glu Ser Phe Ala Ala Thr Ala Asp Phe Arg Glu Gln Ile Leu 
            100                 105                 110         


Arg Val Lys Glu Asp Glu Asn Val Pro Phe Leu Leu Val Gly Asn Lys 
        115                 120                 125             


Ser Asp Leu Glu Asp Lys Arg Gln Val Ser Val Glu Glu Ala Lys Asn 
    130                 135                 140                 


Arg Ala Glu Gln Trp Asn Val Asn Tyr Val Glu Thr Ser Ala Lys Thr 
145                 150                 155                 160 


Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile Arg 
                165                 170                 175     


Ala Arg Lys Met Glu Asp Ser Lys Glu Lys Asn Gly Lys Lys Lys Arg 
            180                 185                 190         


Lys Ser Leu Ala Lys Arg Ile Arg Glu Arg Cys Cys Ile Leu 
        195                 200                 205     


<210> 30
<211> 38
<212> PRT
<213> Human alphaherpesvirus 1

<400> 30
Pro Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
1               5                   10                  15      


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
            20                  25                  30          


Asp Phe Asp Leu Asp Met 
        35              


<210> 31
<211> 53
<212> PRT
<213> Human alphaherpesvirus 1

<400> 31
Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
1               5                   10                  15      


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
            20                  25                  30          


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
        35                  40                  45              


Asp Leu Asp Met Leu 
    50              


<210> 32
<211> 261
<212> PRT
<213> Homo sapiens

<400> 32
Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
1               5                   10                  15      


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
            20                  25                  30          


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
        35                  40                  45              


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
    50                  55                  60                  


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
65                  70                  75                  80  


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
                85                  90                  95      


Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro 
            100                 105                 110         


Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu 
        115                 120                 125             


Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr 
    130                 135                 140                 


Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe 
145                 150                 155                 160 


Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala 
                165                 170                 175     


Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu 
            180                 185                 190         


Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu 
        195                 200                 205             


Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg 
    210                 215                 220                 


Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn 
225                 230                 235                 240 


Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp 
                245                 250                 255     


Phe Ser Ala Leu Leu 
            260     


<210> 33
<211> 190
<212> PRT
<213> Human gammaherpesvirus 8

<400> 33
Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser 
1               5                   10                  15      


Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg 
            20                  25                  30          


Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu 
        35                  40                  45              


Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val 
    50                  55                  60                  


Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro 
65                  70                  75                  80  


Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu 
                85                  90                  95      


Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile 
            100                 105                 110         


Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His 
        115                 120                 125             


Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser 
    130                 135                 140                 


Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn 
145                 150                 155                 160 


Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met 
                165                 170                 175     


His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
            180                 185                 190 


<210> 34
<211> 72
<212> PRT
<213> Homo sapiens

<400> 34
Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe 
1               5                   10                  15      


Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp 
            20                  25                  30          


Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys 
        35                  40                  45              


Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu 
    50                  55                  60                  


Arg Leu Glu Lys Gly Glu Glu Pro 
65                  70          


<210> 35
<211> 289
<212> PRT
<213> Homo sapiens

<400> 35
Glu Ala Ser Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys 
1               5                   10                  15      


Leu Leu Val Lys Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu 
            20                  25                  30          


Gly Gly Gly Ala Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro 
        35                  40                  45              


Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys 
    50                  55                  60                  


Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala 
65                  70                  75                  80  


Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val Gln Glu Thr 
                85                  90                  95      


Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu 
            100                 105                 110         


Val Lys Glu Val Val Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys 
        115                 120                 125             


Ser Gly Lys Gly Leu Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys 
    130                 135                 140                 


Glu Ser Ser Pro Lys Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys 
145                 150                 155                 160 


Lys Glu His His His His His His His Ala Glu Ser Pro Lys Ala Pro 
                165                 170                 175     


Met Pro Leu Leu Pro Pro Pro Pro Pro Pro Glu Pro Gln Ser Ser Glu 
            180                 185                 190         


Asp Pro Ile Ser Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile Cys 
        195                 200                 205             


Lys Glu Glu Lys Met Pro Arg Ala Gly Ser Leu Glu Ser Asp Gly Cys 
    210                 215                 220                 


Pro Lys Glu Pro Ala Lys Thr Gln Pro Met Val Ala Ala Ala Ala Thr 
225                 230                 235                 240 


Thr Thr Thr Thr Thr Thr Thr Thr Val Ala Glu Lys Tyr Lys His Arg 
                245                 250                 255     


Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser Ser Met Pro Arg Pro 
            260                 265                 270         


Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro Val Thr Glu Arg Val 
        275                 280                 285             


Ser 
    


<210> 36
<211> 718
<212> PRT
<213> Homo sapiens

<400> 36
Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp Lys Gly 
1               5                   10                  15      


Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala Val Arg 
            20                  25                  30          


Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile Arg Ile 
        35                  40                  45              


Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His Gly Cys 
    50                  55                  60                  


Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu Lys Val 
65                  70                  75                  80  


Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr Ala Val 
                85                  90                  95      


Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro Met Ala 
            100                 105                 110         


Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr Asn Gly 
        115                 120                 125             


His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr Cys Thr 
    130                 135                 140                 


Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser Phe Gly 
145                 150                 155                 160 


Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg Ser Pro 
                165                 170                 175     


Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His Glu Lys 
            180                 185                 190         


Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala Pro Ile 
        195                 200                 205             


Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu Tyr Glu 
    210                 215                 220                 


Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg Pro Phe 
225                 230                 235                 240 


Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His Arg Asp 
                245                 250                 255     


Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu Thr Arg 
            260                 265                 270         


Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln Leu His 
        275                 280                 285             


Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly Ser Lys 
    290                 295                 300                 


Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val Leu Ala 
305                 310                 315                 320 


Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro Arg Ser 
                325                 330                 335     


Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His Lys Ile 
            340                 345                 350         


Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys Asn Asn 
        355                 360                 365             


Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr Leu Gly 
    370                 375                 380                 


Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr Glu Pro 
385                 390                 395                 400 


His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser Leu Met 
                405                 410                 415     


Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe Ser Trp 
            420                 425                 430         


Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn Asp Ala 
        435                 440                 445             


Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His Cys Thr 
    450                 455                 460                 


Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala Asp Gly 
465                 470                 475                 480 


Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr Leu Ser 
                485                 490                 495     


Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr Gly Val 
            500                 505                 510         


Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser Phe Leu 
        515                 520                 525             


Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp Glu Gln 
    530                 535                 540                 


His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser Asp Asp 
545                 550                 555                 560 


Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu Tyr Trp 
                565                 570                 575     


Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly Val Ala 
            580                 585                 590         


Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg Arg Glu 
        595                 600                 605             


Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His Pro Thr 
    610                 615                 620                 


Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys Pro Gln 
625                 630                 635                 640 


His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu Ala Lys 
                645                 650                 655     


Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala Asn Glu 
            660                 665                 670         


Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile Pro Ser 
        675                 680                 685             


His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val Ser Pro 
    690                 695                 700                 


Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715             


<210> 37
<211> 912
<212> PRT
<213> Homo sapiens

<400> 37
Met Pro Ala Met Pro Ser Ser Gly Pro Gly Asp Thr Ser Ser Ser Ala 
1               5                   10                  15      


Ala Glu Arg Glu Glu Asp Arg Lys Asp Gly Glu Glu Gln Glu Glu Pro 
            20                  25                  30          


Arg Gly Lys Glu Glu Arg Gln Glu Pro Ser Thr Thr Ala Arg Lys Val 
        35                  40                  45              


Gly Arg Pro Gly Arg Lys Arg Lys His Pro Pro Val Glu Ser Gly Asp 
    50                  55                  60                  


Thr Pro Lys Asp Pro Ala Val Ile Ser Lys Ser Pro Ser Met Ala Gln 
65                  70                  75                  80  


Asp Ser Gly Ala Ser Glu Leu Leu Pro Asn Gly Asp Leu Glu Lys Arg 
                85                  90                  95      


Ser Glu Pro Gln Pro Glu Glu Gly Ser Pro Ala Gly Gly Gln Lys Gly 
            100                 105                 110         


Gly Ala Pro Ala Glu Gly Glu Gly Ala Ala Glu Thr Leu Pro Glu Ala 
        115                 120                 125             


Ser Arg Ala Val Glu Asn Gly Cys Cys Thr Pro Lys Glu Gly Arg Gly 
    130                 135                 140                 


Ala Pro Ala Glu Ala Gly Lys Glu Gln Lys Glu Thr Asn Ile Glu Ser 
145                 150                 155                 160 


Met Lys Met Glu Gly Ser Arg Gly Arg Leu Arg Gly Gly Leu Gly Trp 
                165                 170                 175     


Glu Ser Ser Leu Arg Gln Arg Pro Met Pro Arg Leu Thr Phe Gln Ala 
            180                 185                 190         


Gly Asp Pro Tyr Tyr Ile Ser Lys Arg Lys Arg Asp Glu Trp Leu Ala 
        195                 200                 205             


Arg Trp Lys Arg Glu Ala Glu Lys Lys Ala Lys Val Ile Ala Gly Met 
    210                 215                 220                 


Asn Ala Val Glu Glu Asn Gln Gly Pro Gly Glu Ser Gln Lys Val Glu 
225                 230                 235                 240 


Glu Ala Ser Pro Pro Ala Val Gln Gln Pro Thr Asp Pro Ala Ser Pro 
                245                 250                 255     


Thr Val Ala Thr Thr Pro Glu Pro Val Gly Ser Asp Ala Gly Asp Lys 
            260                 265                 270         


Asn Ala Thr Lys Ala Gly Asp Asp Glu Pro Glu Tyr Glu Asp Gly Arg 
        275                 280                 285             


Gly Phe Gly Ile Gly Glu Leu Val Trp Gly Lys Leu Arg Gly Phe Ser 
    290                 295                 300                 


Trp Trp Pro Gly Arg Ile Val Ser Trp Trp Met Thr Gly Arg Ser Arg 
305                 310                 315                 320 


Ala Ala Glu Gly Thr Arg Trp Val Met Trp Phe Gly Asp Gly Lys Phe 
                325                 330                 335     


Ser Val Val Cys Val Glu Lys Leu Met Pro Leu Ser Ser Phe Cys Ser 
            340                 345                 350         


Ala Phe His Gln Ala Thr Tyr Asn Lys Gln Pro Met Tyr Arg Lys Ala 
        355                 360                 365             


Ile Tyr Glu Val Leu Gln Val Ala Ser Ser Arg Ala Gly Lys Leu Phe 
    370                 375                 380                 


Pro Val Cys His Asp Ser Asp Glu Ser Asp Thr Ala Lys Ala Val Glu 
385                 390                 395                 400 


Val Gln Asn Lys Pro Met Ile Glu Trp Ala Leu Gly Gly Phe Gln Pro 
                405                 410                 415     


Ser Gly Pro Lys Gly Leu Glu Pro Pro Glu Glu Glu Lys Asn Pro Tyr 
            420                 425                 430         


Lys Glu Val Tyr Thr Asp Met Trp Val Glu Pro Glu Ala Ala Ala Tyr 
        435                 440                 445             


Ala Pro Pro Pro Pro Ala Lys Lys Pro Arg Lys Ser Thr Ala Glu Lys 
    450                 455                 460                 


Pro Lys Val Lys Glu Ile Ile Asp Glu Arg Thr Arg Glu Arg Leu Val 
465                 470                 475                 480 


Tyr Glu Val Arg Gln Lys Cys Arg Asn Ile Glu Asp Ile Cys Ile Ser 
                485                 490                 495     


Cys Gly Ser Leu Asn Val Thr Leu Glu His Pro Leu Phe Val Gly Gly 
            500                 505                 510         


Met Cys Gln Asn Cys Lys Asn Cys Phe Leu Glu Cys Ala Tyr Gln Tyr 
        515                 520                 525             


Asp Asp Asp Gly Tyr Gln Ser Tyr Cys Thr Ile Cys Cys Gly Gly Arg 
    530                 535                 540                 


Glu Val Leu Met Cys Gly Asn Asn Asn Cys Cys Arg Cys Phe Cys Val 
545                 550                 555                 560 


Glu Cys Val Asp Leu Leu Val Gly Pro Gly Ala Ala Gln Ala Ala Ile 
                565                 570                 575     


Lys Glu Asp Pro Trp Asn Cys Tyr Met Cys Gly His Lys Gly Thr Tyr 
            580                 585                 590         


Gly Leu Leu Arg Arg Arg Glu Asp Trp Pro Ser Arg Leu Gln Met Phe 
        595                 600                 605             


Phe Ala Asn Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro 
    610                 615                 620                 


Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe 
625                 630                 635                 640 


Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val 
            660                 665                 670         


Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg 
        675                 680                 685             


Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val 
    690                 695                 700                 


Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg 
705                 710                 715                 720 


Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg 
                725                 730                 735     


Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe 
            740                 745                 750         


Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp 
        755                 760                 765             


Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu 
    770                 775                 780                 


Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly 
785                 790                 795                 800 


Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln 
                805                 810                 815     


Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr 
            820                 825                 830         


Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe 
        835                 840                 845             


Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met 
    850                 855                 860                 


Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met 
865                 870                 875                 880 


Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro 
                885                 890                 895     


Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val 
            900                 905                 910         


<210> 38
<211> 4215
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
atggacaaga agtacagcat cggcctggac atcggcacca actctgtggg ctgggccgtg       60

atcaccgacg agtacaaggt gcccagcaag aaattcaagg tgctgggcaa caccgaccgg      120

cacagcatca agaagaacct gatcggagcc ctgctgttcg acagcggcga aacagccgag      180

gccacccggc tgaagagaac cgccagaaga agatacacca gacggaagaa ccggatctgc      240

tatctgcaag agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga      300

ctggaagagt ccttcctggt ggaagaggat aagaagcacg agcggcaccc catcttcggc      360

aacatcgtgg acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag      420

aaactggtgg acagcaccga caaggccgac ctgcggctga tctatctggc cctggcccac      480

atgatcaagt tccggggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac      540

gtggacaagc tgttcatcca gctggtgcag acctacaacc agctgttcga ggaaaacccc      600

atcaacgcca gcggcgtgga cgccaaggcc atcctgtctg ccagactgag caagagcaga      660

cggctggaaa atctgatcgc ccagctgccc ggcgagaaga agaatggcct gttcggaaac      720

ctgattgccc tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag      780

gatgccaaac tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc      840

cagatcggcg accagtacgc cgacctgttt ctggccgcca agaacctgtc cgacgccatc      900

ctgctgagcg acatcctgag agtgaacacc gagatcacca aggcccccct gagcgcctct      960

atgatcaaga gatacgacga gcaccaccag gacctgaccc tgctgaaagc tctcgtgcgg     1020

cagcagctgc ctgagaagta caaagagatt ttcttcgacc agagcaagaa cggctacgcc     1080

ggctacattg acggcggagc cagccaggaa gagttctaca agttcatcaa gcccatcctg     1140

gaaaagatgg acggcaccga ggaactgctc gtgaagctga acagagagga cctgctgcgg     1200

aagcagcgga ccttcgacaa cggcagcatc ccccaccaga tccacctggg agagctgcac     1260

gccattctgc ggcggcagga agatttttac ccattcctga aggacaaccg ggaaaagatc     1320

gagaagatcc tgaccttccg catcccctac tacgtgggcc ctctggccag gggaaacagc     1380

agattcgcct ggatgaccag aaagagcgag gaaaccatca ccccctggaa cttcgaggaa     1440

gtggtggaca agggcgcttc cgcccagagc ttcatcgagc ggatgaccaa cttcgataag     1500

aacctgccca acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg     1560

tataacgagc tgaccaaagt gaaatacgtg accgagggaa tgagaaagcc cgccttcctg     1620

agcggcgagc agaaaaaggc catcgtggac ctgctgttca agaccaaccg gaaagtgacc     1680

gtgaagcagc tgaaagagga ctacttcaag aaaatcgagt gcttcgactc cgtggaaatc     1740

tccggcgtgg aagatcggtt caacgcctcc ctgggcacat accacgatct gctgaaaatt     1800

atcaaggaca aggacttcct ggacaatgag gaaaacgagg acattctgga agatatcgtg     1860

ctgaccctga cactgtttga ggacagagag atgatcgagg aacggctgaa aacctatgcc     1920

cacctgttcg acgacaaagt gatgaagcag ctgaagcggc ggagatacac cggctggggc     1980

aggctgagcc ggaagctgat caacggcatc cgggacaagc agtccggcaa gacaatcctg     2040

gatttcctga agtccgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac     2100

agcctgacct ttaaagagga catccagaaa gcccaggtgt ccggccaggg cgatagcctg     2160

cacgagcaca ttgccaatct ggccggcagc cccgccatta agaagggcat cctgcagaca     2220

gtgaaggtgg tggacgagct cgtgaaagtg atgggccggc acaagcccga gaacatcgtg     2280

atcgaaatgg ccagagagaa ccagaccacc cagaagggac agaagaacag ccgcgagaga     2340

atgaagcgga tcgaagaggg catcaaagag ctgggcagcc agatcctgaa agaacacccc     2400

gtggaaaaca cccagctgca gaacgagaag ctgtacctgt actacctgca gaatgggcgg     2460

gatatgtacg tggaccagga actggacatc aaccggctgt ccgactacga tgtggaccat     2520

atcgtgcctc agagctttct gaaggacgac tccatcgaca acaaggtgct gaccagaagc     2580

gacaagaacc ggggcaagag cgacaacgtg ccctccgaag aggtcgtgaa gaagatgaag     2640

aactactggc ggcagctgct gaacgccaag ctgattaccc agagaaagtt cgacaatctg     2700

accaaggccg agagaggcgg cctgagcgaa ctggataagg ccggcttcat caagagacag     2760

ctggtggaaa cccggcagat cacaaagcac gtggcacaga tcctggactc ccggatgaac     2820

actaagtacg acgagaatga caagctgatc cgggaagtga aagtgatcac cctgaagtcc     2880

aagctggtgt ccgatttccg gaaggatttc cagttttaca aagtgcgcga gatcaacaac     2940

taccaccacg cccacgacgc ctacctgaac gccgtcgtgg gaaccgccct gatcaaaaag     3000

taccctaagc tggaaagcga gttcgtgtac ggcgactaca aggtgtacga cgtgcggaag     3060

atgatcgcca agagcgagca ggaaatcggc aaggctaccg ccaagtactt cttctacagc     3120

aacatcatga actttttcaa gaccgagatt accctggcca acggcgagat ccggaagcgg     3180

cctctgatcg agacaaacgg cgaaaccggg gagatcgtgt gggataaggg ccgggatttt     3240

gccaccgtgc ggaaagtgct gagcatgccc caagtgaata tcgtgaaaaa gaccgaggtg     3300

cagacaggcg gcttcagcaa agagtctatc ctgcccaaga ggaacagcga taagctgatc     3360

gccagaaaga aggactggga ccctaagaag tacggcggct tcgacagccc caccgtggcc     3420

tattctgtgc tggtggtggc caaagtggaa aagggcaagt ccaagaaact gaagagtgtg     3480

aaagagctgc tggggatcac catcatggaa agaagcagct tcgagaagaa tcccatcgac     3540

tttctggaag ccaagggcta caaagaagtg aaaaaggacc tgatcatcaa gctgcctaag     3600

tactccctgt tcgagctgga aaacggccgg aagagaatgc tggcctctgc cggcgaactg     3660

cagaagggaa acgaactggc cctgccctcc aaatatgtga acttcctgta cctggccagc     3720

cactatgaga agctgaaggg ctcccccgag gataatgagc agaaacagct gtttgtggaa     3780

cagcacaagc actacctgga cgagatcatc gagcagatca gcgagttctc caagagagtg     3840

atcctggccg acgctaatct ggacaaagtg ctgtccgcct acaacaagca ccgggataag     3900

cccatcagag agcaggccga gaatatcatc cacctgttta ccctgaccaa tctgggagcc     3960

cctgccgcct tcaagtactt tgacaccacc atcgaccgga agaggtacac cagcaccaaa     4020

gaggtgctgg acgccaccct gatccaccag agcatcaccg gcctgtacga gacacggatc     4080

gacctgtctc agctgggagg cgacggatcc cccaagaaga agaggaaagt ctcgagcgac     4140

tacaaagacc atgacggtga ttataaagat catgacatcg attacaagga tgacgatgac     4200

aaggctgcag gatga                                                      4215


<210> 39
<211> 4260
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
atggacaaga agtacagcat cggcctggac atcggcacca actctgtggg ctgggccgtg       60

atcaccgacg agtacaaggt gcccagcaag aaattcaagg tgctgggcaa caccgaccgg      120

cacagcatca agaagaacct gatcggagcc ctgctgttcg acagcggcga aacagccgag      180

gccacccggc tgaagagaac cgccagaaga agatacacca gacggaagaa ccggatctgc      240

tatctgcaag agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga      300

ctggaagagt ccttcctggt ggaagaggat aagaagcacg agcggcaccc catcttcggc      360

aacatcgtgg acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag      420

aaactggtgg acagcaccga caaggccgac ctgcggctga tctatctggc cctggcccac      480

atgatcaagt tccggggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac      540

gtggacaagc tgttcatcca gctggtgcag acctacaacc agctgttcga ggaaaacccc      600

atcaacgcca gcggcgtgga cgccaaggcc atcctgtctg ccagactgag caagagcaga      660

cggctggaaa atctgatcgc ccagctgccc ggcgagaaga agaatggcct gttcggaaac      720

ctgattgccc tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag      780

gatgccaaac tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc      840

cagatcggcg accagtacgc cgacctgttt ctggccgcca agaacctgtc cgacgccatc      900

ctgctgagcg acatcctgag agtgaacacc gagatcacca aggcccccct gagcgcctct      960

atgatcaaga gatacgacga gcaccaccag gacctgaccc tgctgaaagc tctcgtgcgg     1020

cagcagctgc ctgagaagta caaagagatt ttcttcgacc agagcaagaa cggctacgcc     1080

ggctacattg acggcggagc cagccaggaa gagttctaca agttcatcaa gcccatcctg     1140

gaaaagatgg acggcaccga ggaactgctc gtgaagctga acagagagga cctgctgcgg     1200

aagcagcgga ccttcgacaa cggcagcatc ccccaccaga tccacctggg agagctgcac     1260

gccattctgc ggcggcagga agatttttac ccattcctga aggacaaccg ggaaaagatc     1320

gagaagatcc tgaccttccg catcccctac tacgtgggcc ctctggccag gggaaacagc     1380

agattcgcct ggatgaccag aaagagcgag gaaaccatca ccccctggaa cttcgaggaa     1440

gtggtggaca agggcgcttc cgcccagagc ttcatcgagc ggatgaccaa cttcgataag     1500

aacctgccca acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg     1560

tataacgagc tgaccaaagt gaaatacgtg accgagggaa tgagaaagcc cgccttcctg     1620

agcggcgagc agaaaaaggc catcgtggac ctgctgttca agaccaaccg gaaagtgacc     1680

gtgaagcagc tgaaagagga ctacttcaag aaaatcgagt gcttcgactc cgtggaaatc     1740

tccggcgtgg aagatcggtt caacgcctcc ctgggcacat accacgatct gctgaaaatt     1800

atcaaggaca aggacttcct ggacaatgag gaaaacgagg acattctgga agatatcgtg     1860

ctgaccctga cactgtttga ggacagagag atgatcgagg aacggctgaa aacctatgcc     1920

cacctgttcg acgacaaagt gatgaagcag ctgaagcggc ggagatacac cggctggggc     1980

aggctgagcc ggaagctgat caacggcatc cgggacaagc agtccggcaa gacaatcctg     2040

gatttcctga agtccgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac     2100

agcctgacct ttaaagagga catccagaaa gcccaggtgt ccggccaggg cgatagcctg     2160

cacgagcaca ttgccaatct ggccggcagc cccgccatta agaagggcat cctgcagaca     2220

gtgaaggtgg tggacgagct cgtgaaagtg atgggccggc acaagcccga gaacatcgtg     2280

atcgaaatgg ccagagagaa ccagaccacc cagaagggac agaagaacag ccgcgagaga     2340

atgaagcgga tcgaagaggg catcaaagag ctgggcagcc agatcctgaa agaacacccc     2400

gtggaaaaca cccagctgca gaacgagaag ctgtacctgt actacctgca gaatgggcgg     2460

gatatgtacg tggaccagga actggacatc aaccggctgt ccgactacga tgtggaccat     2520

atcgtgcctc agagctttct gaaggacgac tccatcgaca acaaggtgct gaccagaagc     2580

gacaagaacc ggggcaagag cgacaacgtg ccctccgaag aggtcgtgaa gaagatgaag     2640

aactactggc ggcagctgct gaacgccaag ctgattaccc agagaaagtt cgacaatctg     2700

accaaggccg agagaggcgg cctgagcgaa ctggataagg ccggcttcat caagagacag     2760

ctggtggaaa cccggcagat cacaaagcac gtggcacaga tcctggactc ccggatgaac     2820

actaagtacg acgagaatga caagctgatc cgggaagtga aagtgatcac cctgaagtcc     2880

aagctggtgt ccgatttccg gaaggatttc cagttttaca aagtgcgcga gatcaacaac     2940

taccaccacg cccacgacgc ctacctgaac gccgtcgtgg gaaccgccct gatcaaaaag     3000

taccctaagc tggaaagcga gttcgtgtac ggcgactaca aggtgtacga cgtgcggaag     3060

atgatcgcca agagcgagca ggaaatcggc aaggctaccg ccaagtactt cttctacagc     3120

aacatcatga actttttcaa gaccgagatt accctggcca acggcgagat ccggaagcgg     3180

cctctgatcg agacaaacgg cgaaaccggg gagatcgtgt gggataaggg ccgggatttt     3240

gccaccgtgc ggaaagtgct gagcatgccc caagtgaata tcgtgaaaaa gaccgaggtg     3300

cagacaggcg gcttcagcaa agagtctatc ctgcccaaga ggaacagcga taagctgatc     3360

gccagaaaga aggactggga ccctaagaag tacggcggct tcgacagccc caccgtggcc     3420

tattctgtgc tggtggtggc caaagtggaa aagggcaagt ccaagaaact gaagagtgtg     3480

aaagagctgc tggggatcac catcatggaa agaagcagct tcgagaagaa tcccatcgac     3540

tttctggaag ccaagggcta caaagaagtg aaaaaggacc tgatcatcaa gctgcctaag     3600

tactccctgt tcgagctgga aaacggccgg aagagaatgc tggcctctgc cggcgaactg     3660

cagaagggaa acgaactggc cctgccctcc aaatatgtga acttcctgta cctggccagc     3720

cactatgaga agctgaaggg ctcccccgag gataatgagc agaaacagct gtttgtggaa     3780

cagcacaagc actacctgga cgagatcatc gagcagatca gcgagttctc caagagagtg     3840

atcctggccg acgctaatct ggacaaagtg ctgtccgcct acaacaagca ccgggataag     3900

cccatcagag agcaggccga gaatatcatc cacctgttta ccctgaccaa tctgggagcc     3960

cctgccgcct tcaagtactt tgacaccacc atcgaccgga agaggtacac cagcaccaaa     4020

gaggtgctgg acgccaccct gatccaccag agcatcaccg gcctgtacga gacacggatc     4080

gacctgtctc agctgggagg cgacggatcc ggcggaggcg gaagcgggaa aagaaccgcc     4140

gacggcagcg aattcgagcc caagaagaag aggaaagtct cgagcggagg cgactacaaa     4200

gaccatgacg gtgattataa agatcatgac atcgattaca aggatgacga tgacaagtga     4260


<210> 40
<211> 5562
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
atgaaacgga cagccgacgg aagcgagttc gagtcaccaa agaagaagcg gaaagtctcc       60

tcagagactg ggcctgtcgc cgtcgatcca accctgcgcc gccggattga acctcacgag      120

tttgaagtgt tctttgaccc ccgggagctg agaaaggaga catgcctgct gtacgagatc      180

aactggggag gcaggcactc catctggagg cacacctctc agaacacaaa taagcacgtg      240

gaggtgaact tcatcgagaa gtttaccaca gagcggtact tctgccccaa taccagatgt      300

agcatcacat ggtttctgag ctggtcccct tgcggagagt gtagcagggc catcaccgag      360

ttcctgtcca gatatccaca cgtgacactg tttatctaca tcgccaggct gtatcaccac      420

gcagacccaa ggaataggca gggcctgcgc gatctgatca gctccggcgt gaccatccag      480

atcatgacag agcaggagtc cggctactgc tggcggaact tcgtgaatta ttctcctagc      540

aacgaggccc actggcctag gtacccacac ctgtgggtgc gcctgtacgt gctggagctg      600

tattgcatca tcctgggcct gcccccttgt ctgaatatcc tgcggagaaa gcagccccag      660

ctgaccttct ttacaatcgc cctgcagtct tgtcactatc agaggctgcc accccacatc      720

ctgtgggcca caggcctgaa gtctggagga tctagcggag gatcctctgg cagcgagaca      780

ccaggaacaa gcgagtcagc aacaccagag agcagtggcg gcagcagcgg cggcagcgac      840

aagaagtaca gcatcggcct ggacatcggc accaactctg tgggctgggc cgtgatcacc      900

gacgagtaca aggtgcccag caagaaattc aaggtgctgg gcaacaccga ccggcacagc      960

atcaagaaga acctgatcgg agccctgctg ttcgacagcg gcgaaacagc cgaggccacc     1020

cggctgaaga gaaccgccag aagaagatac accagacgga agaaccggat ctgctatctg     1080

caagagatct tcagcaacga gatggccaag gtggacgaca gcttcttcca cagactggaa     1140

gagtccttcc tggtggaaga ggataagaag cacgagcggc accccatctt cggcaacatc     1200

gtggacgagg tggcctacca cgagaagtac cccaccatct accacctgag aaagaaactg     1260

gtggacagca ccgacaaggc cgacctgcgg ctgatctatc tggccctggc ccacatgatc     1320

aagttccggg gccacttcct gatcgagggc gacctgaacc ccgacaacag cgacgtggac     1380

aagctgttca tccagctggt gcagacctac aaccagctgt tcgaggaaaa ccccatcaac     1440

gccagcggcg tggacgccaa ggccatcctg tctgccagac tgagcaagag cagacggctg     1500

gaaaatctga tcgcccagct gcccggcgag aagaagaatg gcctgttcgg aaacctgatt     1560

gccctgagcc tgggcctgac ccccaacttc aagagcaact tcgacctggc cgaggatgcc     1620

aaactgcagc tgagcaagga cacctacgac gacgacctgg acaacctgct ggcccagatc     1680

ggcgaccagt acgccgacct gtttctggcc gccaagaacc tgtccgacgc catcctgctg     1740

agcgacatcc tgagagtgaa caccgagatc accaaggccc ccctgagcgc ctctatgatc     1800

aagagatacg acgagcacca ccaggacctg accctgctga aagctctcgt gcggcagcag     1860

ctgcctgaga agtacaaaga gattttcttc gaccagagca agaacggcta cgccggctac     1920

attgacggcg gagccagcca ggaagagttc tacaagttca tcaagcccat cctggaaaag     1980

atggacggca ccgaggaact gctcgtgaag ctgaacagag aggacctgct gcggaagcag     2040

cggaccttcg acaacggcag catcccccac cagatccacc tgggagagct gcacgccatt     2100

ctgcggcggc aggaagattt ttacccattc ctgaaggaca accgggaaaa gatcgagaag     2160

atcctgacct tccgcatccc ctactacgtg ggccctctgg ccaggggaaa cagcagattc     2220

gcctggatga ccagaaagag cgaggaaacc atcaccccct ggaacttcga ggaagtggtg     2280

gacaagggcg cttccgccca gagcttcatc gagcggatga ccaacttcga taagaacctg     2340

cccaacgaga aggtgctgcc caagcacagc ctgctgtacg agtacttcac cgtgtataac     2400

gagctgacca aagtgaaata cgtgaccgag ggaatgagaa agcccgcctt cctgagcggc     2460

gagcagaaaa aggccatcgt ggacctgctg ttcaagacca accggaaagt gaccgtgaag     2520

cagctgaaag aggactactt caagaaaatc gagtgcttcg actccgtgga aatctccggc     2580

gtggaagatc ggttcaacgc ctccctgggc acataccacg atctgctgaa aattatcaag     2640

gacaaggact tcctggacaa tgaggaaaac gaggacattc tggaagatat cgtgctgacc     2700

ctgacactgt ttgaggacag agagatgatc gaggaacggc tgaaaaccta tgcccacctg     2760

ttcgacgaca aagtgatgaa gcagctgaag cggcggagat acaccggctg gggcaggctg     2820

agccggaagc tgatcaacgg catccgggac aagcagtccg gcaagacaat cctggatttc     2880

ctgaagtccg acggcttcgc caacagaaac ttcatgcagc tgatccacga cgacagcctg     2940

acctttaaag aggacatcca gaaagcccag gtgtccggcc agggcgatag cctgcacgag     3000

cacattgcca atctggccgg cagccccgcc attaagaagg gcatcctgca gacagtgaag     3060

gtggtggacg agctcgtgaa agtgatgggc cggcacaagc ccgagaacat cgtgatcgaa     3120

atggccagag agaaccagac cacccagaag ggacagaaga acagccgcga gagaatgaag     3180

cggatcgaag agggcatcaa agagctgggc agccagatcc tgaaagaaca ccccgtggaa     3240

aacacccagc tgcagaacga gaagctgtac ctgtactacc tgcagaatgg gcgggatatg     3300

tacgtggacc aggaactgga catcaaccgg ctgtccgact acgatgtgga ccatatcgtg     3360

cctcagagct ttctgaagga cgactccatc gacaacaagg tgctgaccag aagcgacaag     3420

aaccggggca agagcgacaa cgtgccctcc gaagaggtcg tgaagaagat gaagaactac     3480

tggcggcagc tgctgaacgc caagctgatt acccagagaa agttcgacaa tctgaccaag     3540

gccgagagag gcggcctgag cgaactggat aaggccggct tcatcaagag acagctggtg     3600

gaaacccggc agatcacaaa gcacgtggca cagatcctgg actcccggat gaacactaag     3660

tacgacgaga atgacaagct gatccgggaa gtgaaagtga tcaccctgaa gtccaagctg     3720

gtgtccgatt tccggaagga tttccagttt tacaaagtgc gcgagatcaa caactaccac     3780

cacgcccacg acgcctacct gaacgccgtc gtgggaaccg ccctgatcaa aaagtaccct     3840

aagctggaaa gcgagttcgt gtacggcgac tacaaggtgt acgacgtgcg gaagatgatc     3900

gccaagagcg agcaggaaat cggcaaggct accgccaagt acttcttcta cagcaacatc     3960

atgaactttt tcaagaccga gattaccctg gccaacggcg agatccggaa gcggcctctg     4020

atcgagacaa acggcgaaac cggggagatc gtgtgggata agggccggga ttttgccacc     4080

gtgcggaaag tgctgagcat gccccaagtg aatatcgtga aaaagaccga ggtgcagaca     4140

ggcggcttca gcaaagagtc tatcctgccc aagaggaaca gcgataagct gatcgccaga     4200

aagaaggact gggaccctaa gaagtacggc ggcttcgaca gccccaccgt ggcctattct     4260

gtgctggtgg tggccaaagt ggaaaagggc aagtccaaga aactgaagag tgtgaaagag     4320

ctgctgggga tcaccatcat ggaaagaagc agcttcgaga agaatcccat cgactttctg     4380

gaagccaagg gctacaaaga agtgaaaaag gacctgatca tcaagctgcc taagtactcc     4440

ctgttcgagc tggaaaacgg ccggaagaga atgctggcct ctgccggcga actgcagaag     4500

ggaaacgaac tggccctgcc ctccaaatat gtgaacttcc tgtacctggc cagccactat     4560

gagaagctga agggctcccc cgaggataat gagcagaaac agctgtttgt ggaacagcac     4620

aagcactacc tggacgagat catcgagcag atcagcgagt tctccaagag agtgatcctg     4680

gccgacgcta atctggacaa agtgctgtcc gcctacaaca agcaccggga taagcccatc     4740

agagagcagg ccgagaatat catccacctg tttaccctga ccaatctggg agcccctgcc     4800

gccttcaagt actttgacac caccatcgac cggaagaggt acaccagcac caaagaggtg     4860

ctggacgcca ccctgatcca ccagagcatc accggcctgt acgagacacg gatcgacctg     4920

tctcagctgg gaggtgacag cggcgggagc ggcgggagcg gggggagcac taatctgagc     4980

gacatcattg agaaggagac tgggaaacag ctggtcattc aggagtccat cctgatgctg     5040

cctgaggagg tggaggaagt gatcggcaac aagccagagt ctgacatcct ggtgcacacc     5100

gcctacgacg agtccacaga tgagaatgtg atgctgctga cctctgacgc ccccgagtat     5160

aagccttggg ccctggtcat ccaggattct aacggcgaga ataagatcaa gatgctgagc     5220

ggaggatccg gaggatctgg aggcagcacc aacctgtctg acatcatcga gaaggagaca     5280

ggcaagcagc tggtcatcca ggagagcatc ctgatgctgc ccgaagaagt cgaagaagtg     5340

atcggaaaca agcctgagag cgatatcctg gtccataccg cctacgacga gagtaccgac     5400

gaaaatgtga tgctgctgac atccgacgcc ccagagtata agccctgggc tctggtcatc     5460

caggattcca acggagagaa caaaatcaaa atgctgtctg gcggctcaaa aagaaccgcc     5520

gacggcagcg aattcgagcc caagaagaag aggaaagtct aa                        5562


<210> 41
<211> 5412
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
atgaaacgga cagccgacgg aagcgagttc gagtcaccaa agaagaagcg gaaagtctct       60

gaagtcgagt ttagccacga gtattggatg aggcacgcac tgaccctggc aaagcgagca      120

tgggatgaaa gagaagtccc cgtgggcgcc gtgctggtgc acaacaatag agtgatcgga      180

gagggatgga acaggccaat cggccgccac gaccctaccg cacacgcaga gatcatggca      240

ctgaggcagg gaggcctggt catgcagaat taccgcctga tcgatgccac cctgtatgtg      300

acactggagc catgcgtgat gtgcgcagga gcaatgatcc acagcaggat cggaagagtg      360

gtgttcggag cacgggacgc caagaccggc gcagcaggct ccctgatgga tgtgctgcac      420

caccccggca tgaaccaccg ggtggagatc acagagggaa tcctggcaga cgagtgcgcc      480

gccctgctga gcgatttctt tagaatgcgg agacaggaga tcaaggccca gaagaaggca      540

cagagctcca ccgactctgg aggatctagc ggaggatcct ctggaagcga gacaccaggc      600

acaagcgagt ccgccacacc agagagctcc ggcggctcct ccggaggatc ctctgaggtg      660

gagttttccc acgagtactg gatgagacat gccctgaccc tggccaagag ggcacgcgat      720

gagagggagg tgcctgtggg agccgtgctg gtgctgaaca atagagtgat cggcgagggc      780

tggaacagag ccatcggcct gcacgaccca acagcccatg ccgaaattat ggccctgaga      840

cagggcggcc tggtcatgca gaactacaga ctgattgacg ccaccctgta cgtgacattc      900

gagccttgcg tgatgtgcgc cggcgccatg atccactcta ggatcggccg cgtggtgttt      960

ggcgtgagga acgcaaaaac cggcgccgca ggctccctga tggacgtgct gcactacccc     1020

ggcatgaatc accgcgtcga aattaccgag ggaatcctgg cagatgaatg tgccgccctg     1080

ctgtgctatt tctttcggat gcctagacag gtgttcaatg ctcagaagaa ggcccagagc     1140

tccaccgact ccggaggatc tagcggaggc tcctctggct ctgagacacc tggcacaagc     1200

gagagcgcaa cacctgaaag cagcgggggc agcagcgggg ggtcagacaa gaagtacagc     1260

atcggcctgg ccatcggcac caactctgtg ggctgggccg tgatcaccga cgagtacaag     1320

gtgcccagca agaaattcaa ggtgctgggc aacaccgacc ggcacagcat caagaagaac     1380

ctgatcggag ccctgctgtt cgacagcggc gaaacagccg aggccacccg gctgaagaga     1440

accgccagaa gaagatacac cagacggaag aaccggatct gctatctgca agagatcttc     1500

agcaacgaga tggccaaggt ggacgacagc ttcttccaca gactggaaga gtccttcctg     1560

gtggaagagg ataagaagca cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg     1620

gcctaccacg agaagtaccc caccatctac cacctgagaa agaaactggt ggacagcacc     1680

gacaaggccg acctgcggct gatctatctg gccctggccc acatgatcaa gttccggggc     1740

cacttcctga tcgagggcga cctgaacccc gacaacagcg acgtggacaa gctgttcatc     1800

cagctggtgc agacctacaa ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg     1860

gacgccaagg ccatcctgtc tgccagactg agcaagagca gacggctgga aaatctgatc     1920

gcccagctgc ccggcgagaa gaagaatggc ctgttcggaa acctgattgc cctgagcctg     1980

ggcctgaccc ccaacttcaa gagcaacttc gacctggccg aggatgccaa actgcagctg     2040

agcaaggaca cctacgacga cgacctggac aacctgctgg cccagatcgg cgaccagtac     2100

gccgacctgt ttctggccgc caagaacctg tccgacgcca tcctgctgag cgacatcctg     2160

agagtgaaca ccgagatcac caaggccccc ctgagcgcct ctatgatcaa gagatacgac     2220

gagcaccacc aggacctgac cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag     2280

tacaaagaga ttttcttcga ccagagcaag aacggctacg ccggctacat tgacggcgga     2340

gccagccagg aagagttcta caagttcatc aagcccatcc tggaaaagat ggacggcacc     2400

gaggaactgc tcgtgaagct gaacagagag gacctgctgc ggaagcagcg gaccttcgac     2460

aacggcagca tcccccacca gatccacctg ggagagctgc acgccattct gcggcggcag     2520

gaagattttt acccattcct gaaggacaac cgggaaaaga tcgagaagat cctgaccttc     2580

cgcatcccct actacgtggg ccctctggcc aggggaaaca gcagattcgc ctggatgacc     2640

agaaagagcg aggaaaccat caccccctgg aacttcgagg aagtggtgga caagggcgct     2700

tccgcccaga gcttcatcga gcggatgacc aacttcgata agaacctgcc caacgagaag     2760

gtgctgccca agcacagcct gctgtacgag tacttcaccg tgtataacga gctgaccaaa     2820

gtgaaatacg tgaccgaggg aatgagaaag cccgccttcc tgagcggcga gcagaaaaag     2880

gccatcgtgg acctgctgtt caagaccaac cggaaagtga ccgtgaagca gctgaaagag     2940

gactacttca agaaaatcga gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg     3000

ttcaacgcct ccctgggcac ataccacgat ctgctgaaaa ttatcaagga caaggacttc     3060

ctggacaatg aggaaaacga ggacattctg gaagatatcg tgctgaccct gacactgttt     3120

gaggacagag agatgatcga ggaacggctg aaaacctatg cccacctgtt cgacgacaaa     3180

gtgatgaagc agctgaagcg gcggagatac accggctggg gcaggctgag ccggaagctg     3240

atcaacggca tccgggacaa gcagtccggc aagacaatcc tggatttcct gaagtccgac     3300

ggcttcgcca acagaaactt catgcagctg atccacgacg acagcctgac ctttaaagag     3360

gacatccaga aagcccaggt gtccggccag ggcgatagcc tgcacgagca cattgccaat     3420

ctggccggca gccccgccat taagaagggc atcctgcaga cagtgaaggt ggtggacgag     3480

ctcgtgaaag tgatgggccg gcacaagccc gagaacatcg tgatcgaaat ggccagagag     3540

aaccagacca cccagaaggg acagaagaac agccgcgaga gaatgaagcg gatcgaagag     3600

ggcatcaaag agctgggcag ccagatcctg aaagaacacc ccgtggaaaa cacccagctg     3660

cagaacgaga agctgtacct gtactacctg cagaatgggc gggatatgta cgtggaccag     3720

gaactggaca tcaaccggct gtccgactac gatgtggacc atatcgtgcc tcagagcttt     3780

ctgaaggacg actccatcga caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag     3840

agcgacaacg tgccctccga agaggtcgtg aagaagatga agaactactg gcggcagctg     3900

ctgaacgcca agctgattac ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc     3960

ggcctgagcg aactggataa ggccggcttc atcaagagac agctggtgga aacccggcag     4020

atcacaaagc acgtggcaca gatcctggac tcccggatga acactaagta cgacgagaat     4080

gacaagctga tccgggaagt gaaagtgatc accctgaagt ccaagctggt gtccgatttc     4140

cggaaggatt tccagtttta caaagtgcgc gagatcaaca actaccacca cgcccacgac     4200

gcctacctga acgccgtcgt gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc     4260

gagttcgtgt acggcgacta caaggtgtac gacgtgcgga agatgatcgc caagagcgag     4320

caggaaatcg gcaaggctac cgccaagtac ttcttctaca gcaacatcat gaactttttc     4380

aagaccgaga ttaccctggc caacggcgag atccggaagc ggcctctgat cgagacaaac     4440

ggcgaaaccg gggagatcgt gtgggataag ggccgggatt ttgccaccgt gcggaaagtg     4500

ctgagcatgc cccaagtgaa tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc     4560

aaagagtcta tcctgcccaa gaggaacagc gataagctga tcgccagaaa gaaggactgg     4620

gaccctaaga agtacggcgg cttcgacagc cccaccgtgg cctattctgt gctggtggtg     4680

gccaaagtgg aaaagggcaa gtccaagaaa ctgaagagtg tgaaagagct gctggggatc     4740

accatcatgg aaagaagcag cttcgagaag aatcccatcg actttctgga agccaagggc     4800

tacaaagaag tgaaaaagga cctgatcatc aagctgccta agtactccct gttcgagctg     4860

gaaaacggcc ggaagagaat gctggcctct gccggcgaac tgcagaaggg aaacgaactg     4920

gccctgccct ccaaatatgt gaacttcctg tacctggcca gccactatga gaagctgaag     4980

ggctcccccg aggataatga gcagaaacag ctgtttgtgg aacagcacaa gcactacctg     5040

gacgagatca tcgagcagat cagcgagttc tccaagagag tgatcctggc cgacgctaat     5100

ctggacaaag tgctgtccgc ctacaacaag caccgggata agcccatcag agagcaggcc     5160

gagaatatca tccacctgtt taccctgacc aatctgggag cccctgccgc cttcaagtac     5220

tttgacacca ccatcgaccg gaagaggtac accagcacca aagaggtgct ggacgccacc     5280

ctgatccacc agagcatcac cggcctgtac gagacacgga tcgacctgtc tcagctggga     5340

ggtgactctg gcggctcaaa aagaaccgcc gacggcagcg aattcgagcc caagaagaag     5400

aggaaagtct aa                                                         5412


