                         SEQUENCE LISTING

<110>  BIONIZ, LLC
 
<120>  ANTAGONISTIC PEPTIDE TARGETING IL-2, IL-9, 
AND IL-15 SIGNALING FOR THE TREATMENT OF CYTOKINE-RELEASE 
SYNDROME AND CYTOKINE STORM ASSOCIATED DISORDERS 

<130>  BION.014WO

<150>  US 63/043636
<151>  2020-06-24

<160>  23

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Ile Lys Glu Phe Leu Gln Arg Phe Ile His Ile Val Gln Ser Ile Ile 
1               5                   10                  15      


Asn Thr Ser 
            

<210>  2
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
1               5                   10                  15      


Asn Thr Ser 
            

<210>  3
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
1               5                   10                  15      


Ser Thr Leu Thr 
            20  


<210>  4
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile 
1               5                   10                  15      


His Gln His Leu Ser 
            20      


<210>  5
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
1               5                   10                  15      


Ser Lys Cys Ser Ser 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Ala Leu Thr Phe Leu Glu Ser Leu Leu Glu Leu Phe Gln Lys Glu Lys 
1               5                   10                  15      


Met Arg Gly Met Arg 
            20      


<210>  7
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
1               5                   10                  15      


Asn Lys Ile Leu 
            20  


<210>  8
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = E or Q or N or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S or R or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = I or K or non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = L or I or aliphatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = Charged amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X = I or K

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X = Any amino acid

<400>  8

Xaa Xaa Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  9
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = E or Q or N or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S or R or polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = I or K or non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = L or I or aliphatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = Non-polar amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = Charged amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X = Any amino acid

<400>  9

Xaa Xaa Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Ile 
1               5                   10                  15      


Xaa Thr Ser 
            


<210>  10
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 8

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 4

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Any amino acid

<400>  10

Xaa Xaa Xaa Ala Xaa Xaa Xaa Ala Xaa Xaa 
1               5                   10  


<210>  11
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 10

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 3

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = Any amino acid

<400>  11

Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa 
1               5                   10      



<210>  12
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<400>  12

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Val Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  13
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 12

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 8

<400>  13

Ile Lys Glu Phe Leu Gln Arg Ala Ile His Ile Ala Gln Ser Ile Ile 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  14
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 15

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 8

<400>  14

Ile Lys Glu Phe Leu Gln Arg Ala Ile His Ile Val Gln Ser Ala Ile 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  15
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 12

<400>  15

Ile Lys Glu Phe Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile Ala 
1               5                   10                  15      


Asn Thr Ser 
            


<210>  16
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 19

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 12

<400>  16

Ile Lys Glu Phe Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile Ile 
1               5                   10                  15      


Asn Thr Ala 
            


<210>  17
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 9

<400>  17

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 8

<400>  18

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Val Gln Ser Ala 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 17

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<400>  19

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ala Asn Thr Ser 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 20

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 13

<400>  20

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ala 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 9

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D stereochemical configuration

<400>  21

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  R-octenylalanine; Linked to S-pentenylalanine at position 16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  S-pentenylalanine; Linked to R-octenylalanine at position 9

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D stereochemical configuration

<400>  22

Ala Ile Lys Glu Ala Leu Gln Arg Ala Ile His Ile Val Gln Ser Ala 
1               5                   10                  15      


Ile Asn Thr Ser 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 5

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 1

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 17

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  S-pentenylalanine; Linked to S-pentenylalanine at position 13

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  D stereochemical configuration

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D stereochemical configuration

<400>  23

Ala Ile Lys Glu Ala Leu Gln Arg Phe Ile His Ile Ala Gln Ser Ile 
1               5                   10                  15      


Ala Asn Thr Ser 
            20  


