                         SEQUENCE LISTING

<110>  UNIVERSITY OF CONNECTICUT
 
<120>  FLAVIVIRUS SIGNAL PEPTIDES, VACCINE CONSTRUCTS, AND METHODS 
       THEREFOR

<130>  UCT0282PCT (20-040)

<150>  US 63/042,173
<151>  2020-06-22

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (engineered SP genus sequence)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X1=M or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X4=A, I, L, M, F, H, V, P, G, Y, W, R, or K

<400>  1

Xaa Gly Ala Xaa Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr Thr 
1               5                   10                  15      


Ala Met Ala 
            


<210>  2
<211>  504
<212>  PRT
<213>  Zika Virus Brazil-ZKV2015

<400>  2

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Thr Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  3
<211>  168
<212>  PRT
<213>  Zika Virus Brazil-ZKV2015

<400>  3

Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg 
1               5                   10                  15      


Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn 
            20                  25                  30          


Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr 
        35                  40                  45              


Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp 
    50                  55                  60                  


Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr 
65                  70                  75                  80  


Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr 
                85                  90                  95      


Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp 
            100                 105                 110         


Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp 
        115                 120                 125             


Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp 
    130                 135                 140                 


Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile 
145                 150                 155                 160 


Leu Leu Ile Ala Pro Ala Tyr Ser 
                165             


<210>  4
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (M+JEV sp)

<400>  4

Met Gly Gly Asn Glu Gly Ser Ile Met Trp Leu Ala Ser Leu Ala Val 
1               5                   10                  15      


Val Ile Ala Cys Ala Gly Ala 
            20              


<210>  5
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (M+M+ZIKA virus Brazil-ZKV2015 signal 
       peptide)

<400>  5

Met Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr Thr 
1               5                   10                  15      


Ala Met Ala 
            


<210>  6
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (D4W)

<400>  6

Met Gly Ala Trp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr Thr 
1               5                   10                  15      


Ala Met Ala 
            


<210>  7
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (D4K))

<400>  7

Met Gly Ala Lys Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr Thr 
1               5                   10                  15      


Ala Met Ala 
            


<210>  8
<211>  3423
<212>  PRT
<213>  Zika Virus Brazil-ZKV2015

<400>  8

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Thr Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Phe Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Val Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  9
<211>  10793
<212>  DNA
<213>  Zika Virus Brazil-ZKV2015

<400>  9
ccaatctgtg aatcagactg cgacagttcg agtttgaagc gaaagctagc aacagtatca       60

acaggtttta ttttggattt ggaaacgaga gtttctggtc atgaaaaacc caaaaaagaa      120

atccggagga ttccggattg tcaatatgct aaaacgcgga gtagcccgtg tgagcccctt      180

tgggggcttg aagaggctgc cagccggact tctgctgggt catgggccca tcaggatggt      240

cttggcgatt ctagcctttt tgagattcac ggcaatcaag ccatcactgg gtctcatcaa      300

tagatggggt tcagtgggga aaaaagaggc tatggaaata ataaagaagt tcaagaaaga      360

tctggctgcc atgctgagaa taatcaatgc caggaaggag aagaagagac gaggcgcaga      420

tactagtgtc ggaatcgttg gcctcctgct gaccacagct atggcagcgg aggtcactag      480

acgtgggagt gcatactata tgtacttgga cagaaacgat gctggggagg ccatatcttt      540

tccaaccaca ttggggatga ataagtgtta tatacagatc atggatcttg gacacatgtg      600

tgatgccacc atgagctatg aatgccctat gctggatgag ggggtggaac cagatgacgt      660

cgattgttgg tgcaacacga cgtcaacttg ggttgtgtac ggaacctgcc atcacaaaaa      720

aggtgaagca cggagatcta gaagagctgt gacgctcccc tcccattcca ctaggaagct      780

gcaaacgcgg tcgcaaacct ggttggaatc aagagaatac acaaagcact tgattagagt      840

cgaaaattgg atattcagga accctggctt cgcgttagca gcagctgcca tcgcttggct      900

tttgggaagc tcaacgagcc aaaaagtcat atacttggtc atgatactgc tgattgcccc      960

ggcatacagc atcaggtgca taggagtcag caatagggac tttgtggaag gtatgtcagg     1020

tgggacttgg gttgatgttg tcttggaaca tgggggttgt gtcaccgtaa tggcacagga     1080

caaaccgact gtcgacatag agctggttac aacaacagtc agcaacatgg cggaggtaag     1140

atcctactgc tatgaggcat caatatcaga catggcttcg gacagccgct gcccaacaca     1200

aggtgaagcc taccttgaca agcaatcaga cactcaatat gtctgcaaaa gaacgttagt     1260

ggacagaggc tggggaaatg gatgtggact ttttggcaaa gggagcctgg tgacatgcgc     1320

taagtttgca tgctccaaga aaatgaccgg gaagagcatc cagccagaga atctggagta     1380

ccggataatg ctgtcagttc atggctccca gcacagtggg atgatcgtta atgacacagg     1440

acatgaaact gatgagaata gagcgaaggt tgagataacg cccaattcac caagagccga     1500

agccaccctg gggggttttg gaagcttagg acttgattgt gaaccgagga caggccttga     1560

cttttcagat ttgtattact tgactatgaa taacaagcac tggttggttc acaaggagtg     1620

gttccacgac attccattac cttggcacgc tggggcagac accggaactc cacactggaa     1680

caacaaagaa gcactggtag agttcaagga cgcacatgcc aaaaggcaaa ctgtcgtggt     1740

tctagggact caagaaggag cagttcacac ggcccttgct ggagctctgg aggctgagat     1800

ggatggtgca aagggaaggc tgtcctctgg ccacttgaaa tgtcgcctga aaatggataa     1860

acttagattg aagggcgtgt catactcctt gtgtaccgca gcgttcacat tcaccaagat     1920

cccggctgaa acactgcacg ggacagtcac agtggaggta cagtacgcag ggacagatgg     1980

accttgcaag gttccagctc agatggcggt ggacatgcaa actctgaccc cagttgggag     2040

gttgataacc gctaaccccg taatcactga aagcactgag aactctaaga tgatgctgga     2100

acttgatcca ccatttgggg actcttacat tgtcatagga gtcggggaga agaagatcac     2160

ccaccactgg cacaggagtg gcagcaccat tggaaaagca tttgaagcca ctgtgagagg     2220

tgccaagaga atggcagtct tgggagacac agcctgggac tttggatcag ttggaggcgc     2280

tctcaactca ttgggcaagg gcatccatca aatttttgga gcagctttca aatcattgtt     2340

tggaggaatg tcctggttct cacaaattct cattggaacg ttgctgatgt ggttgggtct     2400

gaacacaaag aatggatcta tttcccttat gtgcttggcc ttagggggag tgttgatctt     2460

cttatccaca gccgtctctg ctgatgtggg gtgctcggtg gacttctcaa agaaggagac     2520

gagatgtggt acaggggtgt tcgtctataa cgacgttgaa gcctggaggg acaggtacaa     2580

gtaccatcct gactctcccc gtagattggc agcagcagtc aagcaagcct gggaagatgg     2640

tatctgcggg atctcctctg tttcaagaat ggaaaacatc atgtggagat cagtagaagg     2700

ggagcttaac gcaatcctgg aagagaatgg agttcaactg acggtcgttg tgggatctgt     2760

aaaaaacccc atgtggagag gtccacagag attgcccgtg cctgtgaacg agctgcccca     2820

cggctggaag gcttggggga aatcgtactt cgtcagagca gcaaagacaa ataacagctt     2880

tgtcgtggat ggtgacacac tgaaggaatg cccactcaaa catagagcat ggaacagctt     2940

tcttgtggag gatcatgggt tcggggtatt tcacactagt gtctggctca aggttagaga     3000

agattattca ttagagtgtg atccagccgt tattggaaca gctgttaagg gaaaggaggc     3060

tgtacacagt gatctaggct actggattga gagtgagaag aatgacacat ggaggctgaa     3120

gagggcccat ctgatcgaga tgaaaacatg tgaatggcca aagtcccaca cattgtggac     3180

agatggaata gaagagagtg atctgatcat acccaagtct ttagctgggc cactcagcca     3240

tcacaatacc agagagggct acaggaccca aatgaaaggg ccatggcaca gtgaagagct     3300

tgaaattcgg tttgaggaat gcccaggcac taaggtccac gtggaggaaa catgtggaac     3360

aagaggacca tctctgagat caaccactgc aagcggaagg gtgatcgagg aatggtgctg     3420

cagggagtgc acaatgcccc cactgtcgtt ccgggctaaa gatggctgtt ggtatggaat     3480

ggagataagg cccaggaaag aaccagaaag caacttagta aggtcaatgg tgactgcagg     3540

atcaactgat cacatggatc acttctccct tggagtgctt gtgattctgc tcatggtgca     3600

ggaagggctg aagaagagaa tgaccacaaa gatcatcata agcacatcaa tggcagtgct     3660

ggtagctatg atcctgggag gattttcaat gagtgacctg gctaagcttg caattttgat     3720

gggtgccacc ttcgcggaaa tgaacactgg aggagatgta gctcatctgg cgctgatagc     3780

ggcattcaaa gtcagaccag cgttgctggt atctttcatc ttcagagcta attggacacc     3840

ccgtgaaagc atgctgctgg ccttggcctc gtgttttttg caaactgcga tctccgcctt     3900

ggaaggcgac ctgatggttc tcatcaatgg ttttgctttg gcctggttgg caatacgagc     3960

gatggttgtt ccacgcactg acaacatcac cttggcaatc ctggctgctc tgacaccact     4020

ggcccggggc acactgcttg tggcgtggag agcaggcctt gctacttgcg gggggtttat     4080

gctcctctct ctgaagggaa aaggcagtgt gaagaagaac ttaccatttg tcatggccct     4140

gggactaacc gctgtgaggc tggtcgaccc catcaacgtg gtgggactgc tgttgctcac     4200

aaggagtggg aagcggagct ggccccctag cgaagtactc acagctgttg gcctgatatg     4260

cgcattggct ggagggttcg ccaaggcaga tatagagatg gctgggccca tggccgcggt     4320

cggtctgcta attgtcagtt acgtggtctc aggaaagagt gtggacatgt acattgaaag     4380

agcaggtgac atcacatggg aaaaagatgc ggaagtcact ggaaacagtc cccggctcga     4440

tgtggcgcta gatgagagtg gtgacttctc cctggtggag gatgacggtc cccccatgag     4500

agagatcata ctcaaggtgg tcctgatgac catctgtggc atgaacccaa tagccatacc     4560

ctttgcagct ggagcgtggt acgtatacgt gaagactgga aaaaggagtg gtgctctatg     4620

ggatgtgcct gctcccaagg aagtaaaaaa gggggagacc acagatggag tgtacagagt     4680

aatgactcgt agactgctag gttcaacaca agttggagtg ggagttatgc aagagggggt     4740

ctttcacact atgtggcacg tcacaaaagg atccgcgctg agaagcggtg aagggagact     4800

tgatccatac tggggagatg tcaagcagga tctggtgtca tactgtggtc catggaagct     4860

agatgccgcc tgggacgggc acagcgaggt gcagctcttg gccgtgcccc ccggagagag     4920

agcgaggaac atccagactc tgcccggaat atttaagaca aaggatgggg acattggagc     4980

ggttgcgctg gattacccag caggaacttc aggatctcca atcctagaca agtgtgggag     5040

agtgatagga ctttatggca atggggtcgt gataaaaaat gggagttatg ttagtgccat     5100

cacccaaggg aggagggagg aagagactcc tgttgagtgc ttcgagcctt cgatgctgaa     5160

gaagaagcag ctaactgtct tagacttgca tcctggagct gggaaaacca ggagagttct     5220

tcctgaaata gtccgtgaag ccataaaaac aagactccgt actgtgatct tagctccaac     5280

cagggttgtc gctgctgaaa tggaggaagc ccttagaggg cttccagtgc gttatatgac     5340

aacagcagtc aatgtcaccc actctggaac agaaatcgtc gacttaatgt gccatgccac     5400

cttcacttca cgtctactac agccaatcag agtccccaac tataatctgt atattatgga     5460

tgaggcccac ttcacagatc cctcaagcat agcagcaaga ggatacattt caacaagggt     5520

tgagatgggc gaggcggctg ccatcttcat gaccgccacg ccaccaggaa cccgtgacgc     5580

atttccggac tccaactcac caattatgga caccgaagtg gaagtcccag agagagcctg     5640

gagctcaggc tttgattggg tgacggatca ttctggaaaa acagtttggt ttgttccaag     5700

cgtgaggaac ggcaatgaga tcgcagcttg tctgacaaag gctggaaaac gggtcataca     5760

gctcagcaga aagacttttg agacagagtt ccagaaaaca aaacatcaag agtgggactt     5820

tgtcgtgaca actgacattt cagagatggg cgccaacttt aaagctgacc gtgtcataga     5880

ttccaggaga tgcctaaagc cggtcatact tgatggcgag agagtcattc tggctggacc     5940

catgcctgtc acacatgcca gcgctgccca gaggaggggg cgcataggca ggaatcccaa     6000

caaacctgga gatgagtacc tgtatggagg tgggtgcgca gagactgacg aagaccatgc     6060

acactggctt gaagcaagaa tgctccttga caatatttac ctccaagatg gcctcatagc     6120

ctcgctctat cgacctgagg ccgacaaagt agcagccatt gagggagagt tcaagcttag     6180

gacggagcaa aggaagacct ttgtggaact catgaaaaga ggagatcttc ctgtttggct     6240

ggcctatcag gttgcatctg ccggaataac ctacacagat agaagatggt gctttgatgg     6300

cacgaccaac aacaccataa tggaagacag tgtgccggca gaggtgtgga ccagacacgg     6360

agagaaaaga gtgctcaaac cgaggtggat ggacgccaga gtttgttcag atcatgcggc     6420

cctgaagtca ttcaaggagt ttgccgctgg gaaaagagga gcggcttttg gagtgatgga     6480

agccctggga acactgccag gacacatgac agagagattc caggaagcca ttgacaacct     6540

cgctgtgctc atgcgggcag agactggaag caggccttac aaagccgcgg cggcccaatt     6600

gccggagacc ctagagacca ttatgctttt ggggttgctg ggaacagtct cgctgggaat     6660

ctttttcgtc ttgatgagga acaagggcat agggaagatg ggctttggaa tggtgactct     6720

tggggccagc gcatggctca tgtggctctc ggaaattgag ccagccagaa ttgcatgtgt     6780

cctcattgtt gtgttcctat tgctggtggt gctcatacct gagccagaaa agcaaagatc     6840

tccccaggac aaccaaatgg caatcatcat catggtagca gtaggtcttc tgggcttgat     6900

taccgccaat gaactcggat ggttggagag aacaaagagt gacctaagcc atctaatggg     6960

aaggagagag gagggggcaa ccataggatt ctcaatggac attgacctgc ggccagcctc     7020

agcttgggcc atctatgctg ccttgacaac tttcattacc ccagccgtcc aacatgcagt     7080

gaccacttca tacaacaact actccttaat ggcgatggcc acgcaagctg gagtgttgtt     7140

tggtatgggc aaagggatgc cattctacgc atgggacttt ggagtcccgc tgctaatgat     7200

aggttgctac tcacaattaa cacccctgac cctaatagtg gccatcattt tgctcgtggc     7260

gcactacatg tacttgatcc cagggctgca ggcagcagct gcgcgtgctg cccagaagag     7320

aacggcagct ggcatcatga agaaccctgt tgtggatgga atagtggtga ctgacattga     7380

cacaatgaca attgaccccc aagtggagaa aaagatggga caggtgctac tcatagcagt     7440

agccgtctcc agcgccatac tgtcgcggac cgcctggggg tggggggagg ctggggccct     7500

gatcacagcc gcaacttcca ctttgtggga aggctctccg aacaagtact ggaactcctc     7560

tacagccact tcactgtgta acatttttag gggaagttac ttggctggag cttctctaat     7620

ctacacagta acaagaaacg ctggcttggt caagagacgt gggggtggaa caggagagac     7680

cctgggagag aaatggaagg cccgcttgaa ccagatgtcg gccctggagt tctactccta     7740

caaaaagtca ggcatcaccg aggtgtgcag agaagaggcc cgccgcgccc tcaaggacgg     7800

tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca aagctgagat ggttggtgga     7860

gcggggatac ctgcagccct atggaaaggt cattgatctt ggatgtggca gagggggctg     7920

gagttactac gccgccacca tccgcaaagt tcaagaagtg aaaggataca caaaaggagg     7980

ccctggtcat gaagaacccg tgttggtgca aagctatggg tggaacatag tccgtcttaa     8040

gagtggggtg gacgtctttc atatggcggc tgagccgtgt gacacgttgc tgtgtgacat     8100

aggtgagtca tcatctagtc ctgaagtgga agaagcacgg acgctcagag tcctctccat     8160

ggtgggggat tggcttgaaa aaagaccagg agccttttgc ataaaagtgt tgtgcccata     8220

caccagcact atgatggaaa ccctggagcg actgcagcgt aggtatgggg gaggactggt     8280

cagagtgcca ctctcccgca actctacaca tgagatgtac tgggtctctg gagcgaaaag     8340

caacaccata aaaagtgtgt ccaccacgag ccagctcctc ttggggcgca tggacgggcc     8400

taggaggcca gtgaaatatg aggaggatgt gaatctcggc tctggcacgc gggctgtggt     8460

aagctgcgct gaagctccca acatgaagat cattggtaac cgcattgaaa ggatccgcag     8520

tgagcacgcg gaaacgtggt tctttgacga aaaccaccca tataggacat gggcttacca     8580

tggaagctat gtggccccca cacaagggtc agcgtcctct ctaataaacg gggttgtcag     8640

gctcctgtca aaaccctggg atgtggtgac tggagtcaca ggaatagcca tgaccgacac     8700

cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg gacactaggg tgccagaccc     8760

ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc tggttgtgga aagagctagg     8820

caaacacaaa cgaccacgag tctgtaccaa agaagagttc atcaacaagg ttcgtagcaa     8880

tgcagcatta ggggcaatat ttgaagagga aaaagagtgg aagactgcag tggaagctgt     8940

gaacgatcca aggttctggg ctctagtgga caaggaaaga gagcaccacc tgagaggaga     9000

gtgccagagt tgtgtgtaca acatgatggg aaaaagagaa aagaaacaag gggaatttgg     9060

aaaggccaag ggcagccgcg ccatctggta tatgtggcta ggggctagat ttctagagtt     9120

cgaagccctt ggattcttga acgaggatca ctggatgggg agagagaact caggaggtgg     9180

tgttgaaggg ctgggattac aaagactcgg atatgtccta gaagagatga gtcgcatacc     9240

aggaggaagg atgtatgcag atgacactgc tggctgggac acccgcatca gcaggtttga     9300

tctggagaat gaagctctaa tcaccaacca aatggagaaa gggcacaggg ccttggcatt     9360

ggccataatc aagtacacat accaaaacaa agtggtaaag gtccttagac cagctgaaaa     9420

agggaaaaca gttatggaca ttatttcgag acaagaccaa agggggagcg gacaagttgt     9480

cacttacgct cttaacacat ttaccaacct agtggtgcaa ctcattcgga atatggaggc     9540

tgaggaagtt ctagagatgc aagacttgtg gctgctgcgg aggtcagaga aagtgaccaa     9600

ctggttgcag agcaacggat gggataggct caaacgaatg gcagtcagtg gagatgattg     9660

cgttgtgaag ccaattgatg ataggtttgc acatgccctc aggttcttga atgatatggg     9720

aaaagttagg aaggacacac aagagtggaa accctcaact ggatgggaca actgggaaga     9780

agttccgttt tgctcccacc acttcaacaa gctccatctc aaggacggga ggtccattgt     9840

ggttccctgc cgccaccaag atgaactgat tggccgggcc cgcgtctctc caggggcggg     9900

atggagcatc cgggagactg cttgcctagc aaaatcatat gcgcaaatgt ggcagctcct     9960

ttatttccac agaagggacc tccgactgat ggccaatgcc atttgttcat ctgtgccagt    10020

tgactgggtt ccaactggga gaactacctg gtcaatccat ggaaagggag aatggatgac    10080

cactgaagac atgcttgtgg tgtggaacag agtgtggatt gaggagaacg accacatgga    10140

agacaagacc ccagttacga aatggacaga cattccctat ttgggaaaaa gggaagactt    10200

gtggtgtgga tctctcatag ggcacagacc gcgcaccacc tgggctgaga acattaaaaa    10260

tacagtcaac atggtgcgca ggatcatagg tgatgaagaa aagtacatgg actacctatc    10320

cacccaagtt cgctacttgg gtgaagaagg gtctacacct ggagtgctgt gagcaccaat    10380

cttaatgttg tcaggcctgc tagtcagcca cagcttgggg aaagctgtgc agcctgtgac    10440

ccctccagga gaagctgggt aaccaagcct atagtcaggc cgagaacgcc atggcacgga    10500

agaagccatg ctgcctgtga gcccctcaga ggacactgag tcaaaaaacc ccacgcgctt    10560

ggaggcgcag gatgggaaaa gaaggtggcg accttcccca cccttcaatc tggggcctga    10620

actggagatc agctgtggat ctccagaaga gggactagtg gttagaggag accccccgga    10680

aaacgcaaaa cagcatattg acgctgggaa agaccagaga ctccatgagt ttccaccacg    10740

ctggccgcca ggcacagatc gccgaatagc ggcggccggt gtggggaaat cca           10793


<210>  10
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer PCR forward 1

<400>  10
tactcgagat gggcgcaaag                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer-PCR forward 2

<400>  11
acctagcttc tgggcgagtt                                                   20


<210>  12
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer-PCR forward 3

<400>  12
gcccaacaca aggtgaagc                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer PCR reverse 1

<400>  13
ccagtgcttc tttgttgttc c                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer PCRreverse 2

<400>  14
ttgtgatggc aggttccgta                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer PCR reverse 3

<400>  15
cgcggttagt gatggtgatg                                                   20


<210>  16
<211>  16
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer seq forward 1

<400>  16
gtaaaacgac ggccag                                                       16


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer-seq forward 2

<400>  17
cccaagttga tgtcgtgttg                                                   20


<210>  18
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  synthetic primer-seq forward 3

<400>  18
tgaccaagta tatgactttt tggc                                              24


<210>  19
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer seq forward 4

<400>  19
gcagctctaa tgcgctgtta                                                   20


<210>  20
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer seq rev 1

<400>  20
caggaaacag ctatgac                                                      17


<210>  21
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer seq rev 2

<400>  21
aacttagatt gaagggcgtg tc                                                22


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer-seq rev 3

<400>  22
ccaccatttg gggactctta                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic primer-seq rev 4

<400>  23
ccatgatctg tatataacac                                                   20


<210>  24
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (M+POWV Natural SP)

<400>  24

Met Arg Ser Gly Val Asp Trp Thr Trp Ile Phe Leu Thr Met Ala Leu 
1               5                   10                  15      


Thr Met Ala Met Ala Thr 
            20          


<210>  25
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construt (M+D6W POWV SP)

<400>  25

Met Arg Ser Gly Val Trp Trp Thr Trp Ile Phe Leu Thr Met Ala Leu 
1               5                   10                  15      


Thr Met Ala Met Ala Thr 
            20          


<210>  26
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (M+D6K POWV SP)

<400>  26

Met Arg Ser Gly Val Lys Trp Thr Trp Ile Phe Leu Thr Met Ala Leu 
1               5                   10                  15      


Thr Met Ala Met Ala Thr 
            20          


<210>  27
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct (genus engineered POWV SP)


<220>
<221>  MISC_FEATURE
<223>  X1 is M or absent

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X6 is A, I, L, M, F, H, V, P, G, Y, W, R, or K

<400>  27

Xaa Arg Ser Gly Val Xaa Trp Thr Trp Ile Phe Leu Thr Met Ala Leu 
1               5                   10                  15      


Thr Met Ala Met Ala Thr 
            20          


<210>  28
<211>  3415
<212>  PRT
<213>  Powassan Virus (strain LB)

<400>  28

Met Met Thr Thr Ser Lys Gly Lys Gly Gly Gly Pro Pro Arg Arg Lys 
1               5                   10                  15      


Leu Lys Val Thr Ala Asn Lys Ser Arg Pro Ala Thr Ser Pro Met Pro 
            20                  25                  30          


Lys Gly Phe Val Leu Ser Arg Met Leu Gly Ile Leu Trp His Ala Val 
        35                  40                  45              


Thr Gly Thr Ala Arg Pro Pro Val Leu Lys Met Phe Trp Lys Thr Val 
    50                  55                  60                  


Pro Leu Arg Gln Ala Glu Ala Val Leu Lys Lys Ile Lys Arg Val Ile 
65                  70                  75                  80  


Gly Asn Leu Met Gln Ser Leu His Met Arg Gly Arg Arg Arg Ser Gly 
                85                  90                  95      


Val Asp Trp Thr Trp Ile Phe Leu Thr Met Ala Leu Met Thr Met Ala 
            100                 105                 110         


Met Ala Thr Thr Ile His Arg Asp Arg Glu Gly Tyr Met Val Met Arg 
        115                 120                 125             


Ala Ser Gly Arg Asp Ala Ala Ser Gln Val Arg Val Gln Asn Gly Thr 
    130                 135                 140                 


Cys Val Ile Leu Ala Thr Asp Met Gly Glu Trp Cys Glu Asp Ser Ile 
145                 150                 155                 160 


Thr Tyr Ser Cys Val Thr Ile Asp Gln Glu Glu Glu Pro Val Asp Val 
                165                 170                 175     


Asp Cys Phe Cys Arg Gly Val Asp Arg Val Lys Leu Glu Tyr Gly Arg 
            180                 185                 190         


Cys Gly Arg Gln Ala Gly Ser Arg Gly Lys Arg Ser Val Val Ile Pro 
        195                 200                 205             


Thr His Ala Gln Lys Asp Met Val Gly Arg Gly His Ala Trp Leu Lys 
    210                 215                 220                 


Gly Asp Asn Ile Arg Asp His Val Thr Arg Val Glu Gly Trp Met Trp 
225                 230                 235                 240 


Lys Asn Lys Leu Leu Thr Ala Ala Ile Val Ala Leu Ala Trp Leu Met 
                245                 250                 255     


Val Asp Ser Trp Met Ala Arg Val Thr Val Ile Leu Leu Ala Leu Ser 
            260                 265                 270         


Leu Gly Pro Val Tyr Ala Thr Arg Cys Thr His Leu Glu Asn Arg Asp 
        275                 280                 285             


Phe Val Thr Gly Thr Gln Gly Thr Thr Arg Val Ser Leu Val Leu Glu 
    290                 295                 300                 


Leu Gly Gly Cys Val Thr Ile Thr Ala Glu Gly Lys Pro Ser Ile Asp 
305                 310                 315                 320 


Val Trp Leu Glu Asp Ile Phe Gln Glu Ser Pro Ala Glu Thr Arg Glu 
                325                 330                 335     


Tyr Cys Leu His Ala Lys Leu Thr Asn Thr Lys Val Glu Ala Arg Cys 
            340                 345                 350         


Pro Thr Thr Gly Pro Ala Thr Leu Pro Glu Glu His Gln Ala Asn Met 
        355                 360                 365             


Val Cys Lys Arg Asp Gln Ser Asp Arg Gly Trp Gly Asn His Cys Gly 
    370                 375                 380                 


Phe Phe Gly Lys Gly Ser Ile Val Ala Cys Ala Lys Phe Glu Cys Glu 
385                 390                 395                 400 


Glu Ala Lys Lys Ala Val Gly His Val Tyr Asp Ser Thr Lys Ile Thr 
                405                 410                 415     


Tyr Val Val Lys Val Glu Pro His Thr Gly Asp Tyr Leu Ala Ala Asn 
            420                 425                 430         


Glu Thr Asn Ser Asn Arg Lys Ser Ala Gln Phe Thr Val Ala Ser Glu 
        435                 440                 445             


Lys Val Ile Leu Arg Leu Gly Asp Tyr Gly Asp Val Ser Leu Thr Cys 
    450                 455                 460                 


Lys Val Ala Ser Gly Ile Asp Val Ala Gln Thr Val Val Met Ser Leu 
465                 470                 475                 480 


Asp Ser Ser Lys Asp His Leu Pro Ser Ala Trp Gln Val His Arg Asp 
                485                 490                 495     


Trp Phe Glu Asp Leu Ala Leu Pro Trp Lys His Lys Asp Asn Gln Asp 
            500                 505                 510         


Trp Asn Ser Val Glu Lys Leu Val Glu Phe Gly Pro Pro His Ala Val 
        515                 520                 525             


Lys Met Asp Val Phe Asn Leu Gly Asp Gln Thr Ala Val Leu Leu Lys 
    530                 535                 540                 


Ser Leu Ala Gly Val Pro Leu Ala Ser Val Glu Gly Gln Lys Tyr His 
545                 550                 555                 560 


Leu Lys Ser Gly His Val Thr Cys Asp Val Gly Leu Glu Lys Leu Lys 
                565                 570                 575     


Leu Lys Gly Thr Thr Tyr Ser Met Cys Asp Lys Ala Lys Phe Lys Trp 
            580                 585                 590         


Lys Arg Val Pro Val Asp Ser Gly His Asp Thr Val Val Met Glu Val 
        595                 600                 605             


Ser Tyr Thr Gly Ser Asp Lys Pro Cys Arg Ile Pro Val Arg Ala Val 
    610                 615                 620                 


Ala His Gly Val Pro Ala Val Asn Val Ala Met Leu Ile Thr Pro Asn 
625                 630                 635                 640 


Pro Thr Ile Glu Thr Asn Gly Gly Gly Phe Ile Glu Met Gln Leu Pro 
                645                 650                 655     


Pro Gly Asp Asn Ile Ile Tyr Val Gly Asp Leu Ser Gln Gln Trp Phe 
            660                 665                 670         


Gln Lys Gly Ser Thr Ile Gly Arg Met Phe Glu Lys Thr Arg Arg Gly 
        675                 680                 685             


Leu Glu Arg Leu Ser Val Val Gly Glu His Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Val Gly Gly Val Leu Ser Ser Val Gly Lys Ala Ile His Thr Val Leu 
705                 710                 715                 720 


Gly Gly Ala Phe Asn Thr Leu Phe Gly Gly Val Gly Phe Ile Pro Lys 
                725                 730                 735     


Met Leu Leu Gly Val Ala Leu Val Trp Leu Gly Leu Asn Ala Arg Asn 
            740                 745                 750         


Pro Thr Met Ser Met Thr Phe Leu Ala Val Gly Ala Leu Thr Leu Met 
        755                 760                 765             


Met Thr Met Gly Val Gly Ala Asp Tyr Gly Cys Ala Ile Asp Pro Glu 
    770                 775                 780                 


Arg Met Glu Ile Arg Cys Gly Glu Gly Leu Val Val Trp Lys Glu Val 
785                 790                 795                 800 


Ser Glu Trp Tyr Asp Gly Tyr Ala Tyr His Pro Glu Ser Pro Asp Thr 
                805                 810                 815     


Leu Ala Gln Ala Leu Arg Glu Ala Phe Glu Arg Gly Val Cys Gly Val 
            820                 825                 830         


Val Pro Gln Asn Arg Leu Glu Met Ala Met Trp Arg Ser Thr Ala Pro 
        835                 840                 845             


Glu Leu Asn Leu Val Leu Ser Glu Gly Glu Ala Asn Leu Thr Ile Val 
    850                 855                 860                 


Val Asp Lys Thr Asp Pro Ala Asp Tyr Arg Gly Gly Thr Pro Met Val 
865                 870                 875                 880 


Leu Lys Lys Thr Gly Lys Glu Ser Lys Val Ser Trp Lys Ser Trp Gly 
                885                 890                 895     


Lys Ser Ile Leu Trp Ser Val Pro Asp Ser Pro Arg Arg Met Met Met 
            900                 905                 910         


Gly Val Asp Gly Val Gly Glu Cys Pro Leu Tyr Arg Arg Ala Thr Gly 
        915                 920                 925             


Val Phe Thr Val Ala Glu Phe Gly Val Gly Leu Arg Thr Lys Val Phe 
    930                 935                 940                 


Leu Asp Leu Arg Gly Glu Ala Ser Lys Glu Cys Asp Thr Gly Val Met 
945                 950                 955                 960 


Gly Ala Ala Val Lys Asn Gly Lys Ala Ile His Thr Asp Gln Ser Met 
                965                 970                 975     


Trp Met Ser Ser Phe Arg Asn Asp Thr Gly Thr Tyr Ile His Glu Leu 
            980                 985                 990         


Ile Leu Thr Asp Leu Arg Asn Cys  Thr Trp Pro Ala Ser  His Thr Ile 
        995                 1000                 1005             


Asp Asn  Asp Gly Val Leu Asp  Ser His Leu Phe Leu  Pro Val Thr 
    1010                 1015                 1020             


Leu Ala  Gly Pro Arg Ser Lys  Tyr Asn Arg Ile Pro  Gly Tyr Ser 
    1025                 1030                 1035             


Glu Gln  Val Arg Gly Pro Trp  Asp Gln Thr Pro Leu  Arg Val Val 
    1040                 1045                 1050             


Arg Asp  His Cys Pro Gly Thr  Ser Val Arg Ile Asp  Ser His Cys 
    1055                 1060                 1065             


Asp Lys  Arg Gly Ala Ser Val  Arg Ser Thr Thr Glu  Ser Gly Lys 
    1070                 1075                 1080             


Ile Ile  Pro Glu Trp Cys Cys  Arg Ala Cys Glu Leu  Pro Pro Val 
    1085                 1090                 1095             


Thr Phe  Arg Ser Gly Thr Asp  Cys Trp Tyr Ala Met  Glu Ile Arg 
    1100                 1105                 1110             


Pro Val  His Ser Gln Gly Gly  Leu Val Arg Ser Met  Val Val Ala 
    1115                 1120                 1125             


Asp Asn  Gly Ala Leu Leu Ser  Glu Gly Gly Val Pro  Gly Leu Val 
    1130                 1135                 1140             


Ala Val  Phe Val Leu Met Glu  Phe Leu Leu Arg Arg  Arg Pro Gly 
    1145                 1150                 1155             


Ser Val  Thr Ser Ile Leu Trp  Gly Gly Ile Leu Met  Leu Gly Leu 
    1160                 1165                 1170             


Leu Val  Thr Gly Leu Val Arg  Val Glu Glu Ile Val  Arg Tyr Val 
    1175                 1180                 1185             


Ile Ala  Val Gly Val Thr Phe  His Leu Glu Leu Gly  Pro Glu Thr 
    1190                 1195                 1200             


Met Val  Leu Val Met Leu Gln  Ala Val Phe Asn Met  Arg Thr Cys 
    1205                 1210                 1215             


Tyr Leu  Met Gly Phe Leu Val  Lys Arg Val Ile Thr  Thr Arg Glu 
    1220                 1225                 1230             


Val Val  Thr Val Tyr Phe Leu  Leu Leu Val Leu Glu  Met Gly Ile 
    1235                 1240                 1245             


Pro Glu  Met Asn Phe Gly His  Leu Trp Glu Trp Ala  Asp Ala Leu 
    1250                 1255                 1260             


Ala Met  Gly Leu Leu Ile Ile  Lys Ala Ser Ala Met  Glu Asp Arg 
    1265                 1270                 1275             


Arg Gly  Leu Gly Phe Leu Leu  Ala Gly Leu Met Thr  Gln Arg His 
    1280                 1285                 1290             


Leu Val  Ala Val His His Gly  Leu Met Val Phe Leu  Thr Val Ala 
    1295                 1300                 1305             


Leu Ala  Val Val Gly Arg Asn  Ile Tyr Asn Gly Gln  Lys Glu Arg 
    1310                 1315                 1320             


Lys Gly  Leu Cys Phe Thr Val  Pro Leu Ala Ser Leu  Leu Gly Gly 
    1325                 1330                 1335             


Ser Gly  Ser Gly Leu Arg Met  Leu Ala Leu Trp Glu  Cys Leu Gly 
    1340                 1345                 1350             


Gly Arg  Gly Arg Arg Ser Leu  Ser Glu Pro Leu Thr  Val Val Gly 
    1355                 1360                 1365             


Val Met  Leu Ala Met Ala Ser  Gly Leu Leu Arg His  Ser Ser Gln 
    1370                 1375                 1380             


Glu Ala  Leu Leu Ala Leu Ser  Ala Gly Ser Phe Leu  Ile Leu Met 
    1385                 1390                 1395             


Leu Ile  Leu Gly Thr Arg Arg  Leu Gln Leu Thr Ala  Glu Trp Ala 
    1400                 1405                 1410             


Gly Val  Val Glu Trp Asn Pro  Glu Leu Val Asn Glu  Gly Gly Glu 
    1415                 1420                 1425             


Val Ser  Leu Lys Val Arg Gln  Asp Ala Met Gly Asn  Leu His Leu 
    1430                 1435                 1440             


Thr Glu  Val Glu Arg Glu Glu  Arg Arg Leu Ala Leu  Trp Leu Val 
    1445                 1450                 1455             


Phe Gly  Leu Leu Ala Ser Ala  Tyr His Trp Ser Gly  Ile Leu Val 
    1460                 1465                 1470             


Thr Met  Gly Ala Trp Thr Val  Tyr Glu Leu Phe Ser  Ser Thr Arg 
    1475                 1480                 1485             


Arg Thr  Asp Leu Val Phe Ser  Gly Gln Leu Pro Asp  Gln Gly Glu 
    1490                 1495                 1500             


Lys Arg  Ser Phe Asp Ile Lys  Glu Gly Val Tyr Arg  Ile Tyr Ala 
    1505                 1510                 1515             


Pro Gly  Leu Phe Trp Gly Tyr  Arg Gln Ile Gly Val  Gly Tyr Gly 
    1520                 1525                 1530             


Thr Lys  Gly Val Leu His Thr  Met Trp His Val Thr  Arg Gly Ala 
    1535                 1540                 1545             


Ala Leu  Ser Val Glu Gly Ala  Thr Ser Gly Pro Tyr  Trp Ala Asp 
    1550                 1555                 1560             


Val Arg  Glu Asp Val Val Cys  Tyr Gly Gly Ala Trp  Gly Leu Asp 
    1565                 1570                 1575             


Lys Lys  Trp Gly Gly Glu Val  Val Gln Val His Ala  Phe Pro Pro 
    1580                 1585                 1590             


Asp Ser  Gly His Lys Ile His  Gln Cys Gln Pro Gly  Lys Leu Asn 
    1595                 1600                 1605             


Leu Glu  Gly Gly Arg Val Leu  Gly Ala Ile Pro Ile  Asp Leu Pro 
    1610                 1615                 1620             


Arg Gly  Thr Ser Gly Ser Pro  Ile Ile Asn Ala Gln  Gly Asp Val 
    1625                 1630                 1635             


Leu Gly  Leu Tyr Gly Asn Gly  Leu Lys Ser Asn Asp  Val Tyr Ile 
    1640                 1645                 1650             


Ser Ser  Ile Ala Gln Gly Asn  Val Glu Lys Ser Arg  Pro Glu Met 
    1655                 1660                 1665             


Pro Leu  Ala Val Gln Gly Gly  Lys Trp Thr Ser Lys  Gly Ser Ile 
    1670                 1675                 1680             


Thr Val  Leu Asp Met His Pro  Gly Ser Gly Lys Thr  His Arg Val 
    1685                 1690                 1695             


Leu Pro  Glu Leu Ile Arg Glu  Cys Ile Asp Lys Arg  Leu Arg Thr 
    1700                 1705                 1710             


Val Val  Leu Ala Pro Thr Arg  Val Val Leu Lys Glu  Met Glu Arg 
    1715                 1720                 1725             


Ala Leu  Gln Gly Lys Arg Val  Lys Phe His Ser Ala  Ala Val Asp 
    1730                 1735                 1740             


Asn Ala  Ser Ser Ser Ser Gly  Ala Ile Val Asp Val  Met Cys His 
    1745                 1750                 1755             


Ala Thr  Tyr Val Asn Arg Arg  Leu Leu Pro Gln Gly  Arg Gln Asn 
    1760                 1765                 1770             


Trp Glu  Val Ala Ile Met Asp  Glu Ala His Trp Thr  Asp Pro His 
    1775                 1780                 1785             


Ser Ile  Ala Ala Arg Gly His  Leu Tyr Ser Leu Ala  Lys Glu Asn 
    1790                 1795                 1800             


Arg Cys  Ala Leu Val Leu Met  Thr Ala Thr Pro Pro  Gly Lys Ser 
    1805                 1810                 1815             


Glu Ala  Phe Pro Glu Ser Lys  Gly Ala Ile Val Ser  Glu Glu Lys 
    1820                 1825                 1830             


Pro Ile  Pro Glu Gly Glu Trp  Arg Asp Gly Phe Asp  Trp Ile Thr 
    1835                 1840                 1845             


Glu Phe  Glu Gly Arg Thr Ala  Trp Phe Val Pro Ser  Ile Ala Lys 
    1850                 1855                 1860             


Gly Gly  Ala Ile Ala Arg Thr  Leu Arg Gln Lys Gly  Lys Ser Val 
    1865                 1870                 1875             


Ile Cys  Leu Asn Ser Lys Thr  Phe Asp Lys Asp Tyr  Gly Arg Val 
    1880                 1885                 1890             


His Glu  Glu Lys Pro Asp Phe  Val Val Thr Thr Asp  Ile Ser Glu 
    1895                 1900                 1905             


Met Gly  Ala Asn Leu Asp Val  Asn Arg Val Ile Asp  Gly Arg Thr 
    1910                 1915                 1920             


Asn Ile  Lys Pro Glu Glu Ile  Asp Gly Lys Val Glu  Leu Ile Gly 
    1925                 1930                 1935             


Thr Arg  Arg Val Thr Thr Ala  Ser Ala Ala Gln Arg  Arg Gly Arg 
    1940                 1945                 1950             


Val Gly  Arg His Glu Gly Arg  Thr Asp Leu Tyr Val  Tyr Ser Gly 
    1955                 1960                 1965             


Gln Cys  Asp Asp Asp Asp Ser  Ser Leu Val Gln Trp  Lys Glu Ala 
    1970                 1975                 1980             


Gln Ile  Leu Leu Asp Asn Ile  Thr Thr Val Arg Gly  Pro Val Ala 
    1985                 1990                 1995             


Thr Phe  Tyr Gly Pro Glu Gln  Gly Lys Met Leu Glu  Val Ala Gly 
    2000                 2005                 2010             


His Phe  Arg Leu Thr Glu Glu  Lys Arg Lys His Phe  Arg His Leu 
    2015                 2020                 2025             


Leu Thr  Asn Cys Asp Phe Thr  Pro Trp Leu Ala Trp  His Val Ala 
    2030                 2035                 2040             


Ala Asn  Thr Ala Cys Val Thr  Asp Arg Lys Trp Thr  Trp Glu Gly 
    2045                 2050                 2055             


Pro Asp  Glu Asn Ala Ile Asp  Gly Pro Gly Gly Glu  Leu Val Thr 
    2060                 2065                 2070             


Phe Arg  Ser Pro Asn Gly Ala  Glu Arg Lys Leu Lys  Pro Ile Trp 
    2075                 2080                 2085             


Lys Asp  Ser Arg Met Phe Arg  Glu Gly Arg Asp Val  Ala Asp Phe 
    2090                 2095                 2100             


Ile Gln  Tyr Ala Ser Gly Arg  Arg Ser Ala Val Asp  Ile Leu Thr 
    2105                 2110                 2115             


Gly Leu  Gly Gly Val Pro Asp  Leu Leu Arg Leu Arg  Cys Thr Ala 
    2120                 2125                 2130             


Ala Trp  Asp Val Val Tyr Thr  Leu Leu Asn Glu Thr  Pro Gly Ser 
    2135                 2140                 2145             


Arg Ala  Met Lys Met Ala Glu  Arg Asp Ala Pro Glu  Ala Met Leu 
    2150                 2155                 2160             


Thr Leu  Leu Glu Val Ala Val  Leu Gly Ile Ala Thr  Leu Gly Val 
    2165                 2170                 2175             


Val Trp  Cys Phe Ile Val Arg  Thr Ser Val Ser Arg  Met Val Leu 
    2180                 2185                 2190             


Gly Thr  Leu Val Leu Ala Val  Ala Leu Ile Leu Leu  Trp Leu Gly 
    2195                 2200                 2205             


Gly Met  Asp Tyr Gly Thr Met  Ala Gly Val Ala Leu  Ile Phe Tyr 
    2210                 2215                 2220             


Leu Leu  Leu Thr Val Leu Gln  Pro Glu Pro Gly Lys  Gln Arg Ser 
    2225                 2230                 2235             


Gly Glu  Asp Asn Arg Leu Ala  Phe Leu Leu Ile Gly  Leu Gly Ser 
    2240                 2245                 2250             


Val Val  Gly Leu Val Ala Ala  Asn Glu Leu Gly Tyr  Leu Glu Gln 
    2255                 2260                 2265             


Thr Lys  Thr Asp Ile Ser Gly  Leu Phe Arg Arg Glu  Asp Gln Gly 
    2270                 2275                 2280             


Gly Met  Val Trp Asp Ala Trp  Thr Asn Ile Asp Ile  Gln Pro Ala 
    2285                 2290                 2295             


Arg Ser  Trp Gly Thr Tyr Val  Leu Ile Val Ser Leu  Phe Thr Pro 
    2300                 2305                 2310             


Tyr Met  Leu His Gln Leu Gln  Thr Lys Ile Gln Arg  Leu Val Asn 
    2315                 2320                 2325             


Ser Ser  Val Ala Ala Gly Thr  Gln Ala Met Arg Asp  Leu Gly Gly 
    2330                 2335                 2340             


Gly Thr  Pro Phe Phe Gly Val  Ala Gly His Val Val  Ala Leu Gly 
    2345                 2350                 2355             


Val Thr  Ser Leu Val Gly Ala  Thr Pro Thr Ser Leu  Ala Leu Gly 
    2360                 2365                 2370             


Val Ala  Leu Ala Ala Leu His  Leu Ala Val Val Thr  Ser Gly Leu 
    2375                 2380                 2385             


Glu Ala  Glu Leu Thr Gln Arg  Ala His Arg Ala Phe  Phe Ser Ala 
    2390                 2395                 2400             


Met Val  Lys Asn Pro Met Val  Asp Gly Glu Ile Ile  Asn Pro Ile 
    2405                 2410                 2415             


Pro Asp  Gly Asp Pro Lys Pro  Ala Leu Tyr Glu Arg  Lys Met Ser 
    2420                 2425                 2430             


Leu Phe  Leu Ala Ile Gly Leu  Cys Ile Ala Ala Val  Ala Leu Asn 
    2435                 2440                 2445             


Arg Thr  Ala Ala Ala Met Thr  Glu Ala Gly Ala Val  Ala Val Ala 
    2450                 2455                 2460             


Ala Leu  Gly Gln Leu Leu Arg  Pro Glu Glu Glu Ser  Trp Trp Thr 
    2465                 2470                 2475             


Met Pro  Met Ala Cys Gly Met  Ala Gly Leu Val Arg  Gly Ser Leu 
    2480                 2485                 2490             


Trp Gly  Leu Leu Pro Val Leu  His Arg Ile Trp Leu  Arg Thr Gln 
    2495                 2500                 2505             


Gly Ala  Arg Arg Gly Gly Ala  Glu Gly Ser Thr Leu  Gly Asp Ile 
    2510                 2515                 2520             


Trp Lys  Gln Arg Leu Asn Ser  Cys Thr Lys Glu Glu  Phe Phe Ala 
    2525                 2530                 2535             


Tyr Arg  Arg Thr Gly Val Met  Glu Thr Asn Arg Asp  Gln Ala Arg 
    2540                 2545                 2550             


Glu Leu  Leu Arg Arg Gly Glu  Thr Asn Met Gly Leu  Ala Val Ser 
    2555                 2560                 2565             


Arg Gly  Cys Ala Lys Leu Ala  Trp Leu Glu Glu Arg  Gly Tyr Ala 
    2570                 2575                 2580             


Thr Leu  Lys Gly Glu Val Val  Asp Leu Gly Cys Gly  Arg Gly Gly 
    2585                 2590                 2595             


Trp Ser  Tyr Tyr Ala Ala Ser  Arg Pro Ser Val Met  Ala Val Arg 
    2600                 2605                 2610             


Ala Tyr  Thr Ile Gly Gly Lys  Gly His Glu Ala Pro  Arg Leu Val 
    2615                 2620                 2625             


Thr Ser  Leu Gly Trp Asn Leu  Ile Lys Phe Arg Ser  Gly Met Asp 
    2630                 2635                 2640             


Val Phe  Ser Met Ala Thr Thr  Arg Ala Asp Thr Ile  Leu Cys Asp 
    2645                 2650                 2655             


Ile Gly  Glu Ser Ser Pro Asp  Pro Glu Lys Glu Gly  Ala Arg Ser 
    2660                 2665                 2670             


Arg Arg  Val Ile Leu Leu Met  Glu Gln Trp Lys Ala  Arg Asn Pro 
    2675                 2680                 2685             


Asp Ala  Ala Ala Val Phe Lys  Val Leu Ala Pro Tyr  Arg Pro Glu 
    2690                 2695                 2700             


Val Leu  Glu Ala Leu His Arg  Phe Gln Leu Gln Trp  Gly Gly Gly 
    2705                 2710                 2715             


Leu Val  Arg Val Pro Phe Ser  Arg Asn Ser Thr His  Glu Met Tyr 
    2720                 2725                 2730             


Tyr Ser  Thr Ala Val Thr Gly  Asn Leu Val Asn Ser  Val Asn Val 
    2735                 2740                 2745             


Leu Ser  Arg Lys Leu Leu Ala  Arg Phe Gly Glu Thr  Arg Gly Pro 
    2750                 2755                 2760             


Ile Gln  Val Pro Glu Ile Asp  Leu Gly Thr Gly Thr  Arg Cys Val 
    2765                 2770                 2775             


Thr Leu  Ala Glu Asp Lys Val  Lys Pro Arg Asp Val  Ala Glu Arg 
    2780                 2785                 2790             


Ile Gly  Ala Leu Arg Glu Gln  Tyr Ser Glu Ser Trp  His Glu Asp 
    2795                 2800                 2805             


Lys Glu  His Pro Tyr Arg Thr  Trp Gln Tyr Trp Gly  Ser Tyr Arg 
    2810                 2815                 2820             


Thr Pro  Ala Thr Gly Ser Ala  Ala Ser Leu Ile Asn  Gly Val Val 
    2825                 2830                 2835             


Lys Leu  Leu Ser Trp Pro Trp  Asn Ala Arg Glu Asp  Val Thr Arg 
    2840                 2845                 2850             


Met Ala  Met Thr Asp Thr Thr  Ala Phe Gly Gln Gln  Arg Val Phe 
    2855                 2860                 2865             


Lys Glu  Lys Val Asp Thr Lys  Ala Gln Glu Pro Gln  Pro Gly Thr 
    2870                 2875                 2880             


Arg Val  Ile Met Arg Ala Val  Ser Asp Trp Leu Leu  Glu His Leu 
    2885                 2890                 2895             


Ser Arg  Arg Ala Lys Val Arg  Met Cys Thr Lys Asp  Glu Phe Ile 
    2900                 2905                 2910             


Ala Lys  Val Arg Ser Asn Ala  Ala Leu Gly Ala Trp  Ser Asp Glu 
    2915                 2920                 2925             


Gln Asn  Lys Trp Ser Ser Ala  Lys Glu Ala Val Glu  Asp Pro Glu 
    2930                 2935                 2940             


Phe Trp  Lys Leu Val Asp Glu  Glu Arg Ser Arg His  Leu Lys Gly 
    2945                 2950                 2955             


Gln Cys  Arg His Cys Val Tyr  Asn Met Met Gly Lys  Arg Glu Lys 
    2960                 2965                 2970             


Lys Leu  Gly Glu Phe Gly Val  Ala Lys Gly Ser Arg  Ala Ile Trp 
    2975                 2980                 2985             


Tyr Met  Trp Leu Gly Ser Arg  Phe Leu Glu Phe Glu  Val Leu Gly 
    2990                 2995                 3000             


Phe Leu  Asn Glu Glu His Trp  Ala Ser Arg Glu Val  Ser Gly Ala 
    3005                 3010                 3015             


Gly Val  Glu Gly Thr Ser Leu  Asn Tyr Leu Gly Trp  Leu Leu Arg 
    3020                 3025                 3030             


Glu Leu  Gly Met Lys Asp Gly  Gly Lys Leu Tyr Ala  Asp Asp Thr 
    3035                 3040                 3045             


Ala Gly  Trp Asp Thr Arg Ile  Thr Asn Ala Asp Leu  Glu Asp Glu 
    3050                 3055                 3060             


Glu Gln  Ile Leu Arg Tyr Met  Glu Gly Glu His His  Val Leu Ala 
    3065                 3070                 3075             


Lys Thr  Ile Leu Glu Lys Ala  Tyr His Ala Lys Val  Val Lys Val 
    3080                 3085                 3090             


Ala Arg  Pro Ser Pro Gln Gly  Gly Cys Val Met Asp  Val Ile Thr 
    3095                 3100                 3105             


Arg Arg  Asp Gln Arg Gly Ser  Gly Gln Val Val Thr  Tyr Ala Leu 
    3110                 3115                 3120             


Asn Thr  Ile Thr Asn Met Lys  Val Gln Leu Ile Arg  Met Met Glu 
    3125                 3130                 3135             


Gly Glu  Gly Val Ile Gly Pro  Ala Asp Ser Gln Asp  Pro Arg Leu 
    3140                 3145                 3150             


Lys Arg  Val Glu Thr Trp Leu  Lys Glu His Gly Val  Glu Arg Leu 
    3155                 3160                 3165             


Gly Arg  Met Leu Val Ser Gly  Asp Asp Cys Val Val  Lys Pro Ile 
    3170                 3175                 3180             


Asp Asp  Arg Phe Gly Lys Ala  Leu Tyr Phe Leu Asn  Asp Met Ala 
    3185                 3190                 3195             


Lys Val  Arg Lys Asp Val Gly  Glu Trp Glu Pro Ser  Met Gly Phe 
    3200                 3205                 3210             


Thr Glu  Trp Glu Glu Val Pro  Phe Cys Ser His His  Phe His Glu 
    3215                 3220                 3225             


Leu Val  Met Lys Asp Gly Arg  Ser Leu Ile Val Pro  Cys Arg Asp 
    3230                 3235                 3240             


Gln Asp  Glu Leu Val Gly Arg  Ala Arg Val Ser Pro  Gly Cys Gly 
    3245                 3250                 3255             


Trp Ser  Val Arg Glu Thr Ala  Cys Leu Ser Lys Ala  Tyr Gly Gln 
    3260                 3265                 3270             


Met Trp  Leu Leu Asn Tyr Phe  His Arg Arg Asp Leu  Arg Thr Leu 
    3275                 3280                 3285             


Gly Phe  Ala Ile Cys Ser Ala  Val Pro Val Ser Trp  Val Pro Met 
    3290                 3295                 3300             


Gly Arg  Thr Thr Trp Ser Ile  His Ala Ser Gly Glu  Trp Met Thr 
    3305                 3310                 3315             


Thr Glu  Asp Met Leu Arg Ile  Trp Asn Lys Val Trp  Ile Leu Asp 
    3320                 3325                 3330             


Asn Pro  His Met Glu Asp Lys  Gln Thr Val Asp Glu  Trp Arg Asp 
    3335                 3340                 3345             


Ile Pro  Tyr Leu Pro Lys Thr  Gln Asp Leu Val Cys  Ser Ser Leu 
    3350                 3355                 3360             


Val Gly  Arg Lys Glu Arg Ala  Glu Trp Ala Lys Asn  Ile Trp Gly 
    3365                 3370                 3375             


Ser Val  Glu Lys Val Arg Lys  Leu Ile Gly Pro Glu  Asp Tyr Arg 
    3380                 3385                 3390             


Asp Tyr  Leu Ser Ser Met Asp  Arg His Asp Leu His  Trp Glu Leu 
    3395                 3400                 3405             


Lys Leu  Glu Ser Ser Ile Ile  
    3410                 3415 


<210>  29
<211>  497
<212>  PRT
<213>  powassan virus (strain LB)

<400>  29

Thr Arg Cys Thr His Leu Glu Asn Arg Asp Phe Val Thr Gly Thr Gln 
1               5                   10                  15      


Gly Thr Thr Arg Val Ser Leu Val Leu Glu Leu Gly Gly Cys Val Thr 
            20                  25                  30          


Ile Thr Ala Glu Gly Lys Pro Ser Ile Asp Val Trp Leu Glu Asp Ile 
        35                  40                  45              


Phe Gln Glu Ser Pro Ala Glu Thr Arg Glu Tyr Cys Leu His Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Lys Val Glu Ala Arg Cys Pro Thr Thr Gly Pro Ala 
65                  70                  75                  80  


Thr Leu Pro Glu Glu His Gln Ala Asn Met Val Cys Lys Arg Asp Gln 
                85                  90                  95      


Ser Asp Arg Gly Trp Gly Asn His Cys Gly Phe Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Ala Cys Ala Lys Phe Glu Cys Glu Glu Ala Lys Lys Ala Val 
        115                 120                 125             


Gly His Val Tyr Asp Ser Thr Lys Ile Thr Tyr Val Val Lys Val Glu 
    130                 135                 140                 


Pro His Thr Gly Asp Tyr Leu Ala Ala Asn Glu Thr Asn Ser Asn Arg 
145                 150                 155                 160 


Lys Ser Ala Gln Phe Thr Val Ala Ser Glu Lys Val Ile Leu Arg Leu 
                165                 170                 175     


Gly Asp Tyr Gly Asp Val Ser Leu Thr Cys Lys Val Ala Ser Gly Ile 
            180                 185                 190         


Asp Val Ala Gln Thr Val Val Met Ser Leu Asp Ser Ser Lys Asp His 
        195                 200                 205             


Leu Pro Ser Ala Trp Gln Val His Arg Asp Trp Phe Glu Asp Leu Ala 
    210                 215                 220                 


Leu Pro Trp Lys His Lys Asp Asn Gln Asp Trp Asn Ser Val Glu Lys 
225                 230                 235                 240 


Leu Val Glu Phe Gly Pro Pro His Ala Val Lys Met Asp Val Phe Asn 
                245                 250                 255     


Leu Gly Asp Gln Thr Ala Val Leu Leu Lys Ser Leu Ala Gly Val Pro 
            260                 265                 270         


Leu Ala Ser Val Glu Gly Gln Lys Tyr His Leu Lys Ser Gly His Val 
        275                 280                 285             


Thr Cys Asp Val Gly Leu Glu Lys Leu Lys Leu Lys Gly Thr Thr Tyr 
    290                 295                 300                 


Ser Met Cys Asp Lys Ala Lys Phe Lys Trp Lys Arg Val Pro Val Asp 
305                 310                 315                 320 


Ser Gly His Asp Thr Val Val Met Glu Val Ser Tyr Thr Gly Ser Asp 
                325                 330                 335     


Lys Pro Cys Arg Ile Pro Val Arg Ala Val Ala His Gly Val Pro Ala 
            340                 345                 350         


Val Asn Val Ala Met Leu Ile Thr Pro Asn Pro Thr Ile Glu Thr Asn 
        355                 360                 365             


Gly Gly Gly Phe Ile Glu Met Gln Leu Pro Pro Gly Asp Asn Ile Ile 
    370                 375                 380                 


Tyr Val Gly Asp Leu Ser Gln Gln Trp Phe Gln Lys Gly Ser Thr Ile 
385                 390                 395                 400 


Gly Arg Met Phe Glu Lys Thr Arg Arg Gly Leu Glu Arg Leu Ser Val 
                405                 410                 415     


Val Gly Glu His Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Ser 
            420                 425                 430         


Ser Val Gly Lys Ala Ile His Thr Val Leu Gly Gly Ala Phe Asn Thr 
        435                 440                 445             


Leu Phe Gly Gly Val Gly Phe Ile Pro Lys Met Leu Leu Gly Val Ala 
    450                 455                 460                 


Leu Val Trp Leu Gly Leu Asn Ala Arg Asn Pro Thr Met Ser Met Thr 
465                 470                 475                 480 


Phe Leu Ala Val Gly Ala Leu Thr Leu Met Met Thr Met Gly Val Gly 
                485                 490                 495     


Ala 
    


<210>  30
<211>  163
<212>  PRT
<213>  powassan virus (LB strain)

<400>  30

Thr Ile His Arg Asp Arg Glu Gly Tyr Met Val Met Arg Ala Ser Gly 
1               5                   10                  15      


Arg Asp Ala Ala Ser Gln Val Arg Val Gln Asn Gly Thr Cys Val Ile 
            20                  25                  30          


Leu Ala Thr Asp Met Gly Glu Trp Cys Glu Asp Ser Ile Thr Tyr Ser 
        35                  40                  45              


Cys Val Thr Ile Asp Gln Glu Glu Glu Pro Val Asp Val Asp Cys Phe 
    50                  55                  60                  


Cys Arg Gly Val Asp Arg Val Lys Leu Glu Tyr Gly Arg Cys Gly Arg 
65                  70                  75                  80  


Gln Ala Gly Ser Arg Gly Lys Arg Ser Val Val Ile Pro Thr His Ala 
                85                  90                  95      


Gln Lys Asp Met Val Gly Arg Gly His Ala Trp Leu Lys Gly Asp Asn 
            100                 105                 110         


Ile Arg Asp His Val Thr Arg Val Glu Gly Trp Met Trp Lys Asn Lys 
        115                 120                 125             


Leu Leu Thr Ala Ala Ile Val Ala Leu Ala Trp Leu Met Val Asp Ser 
    130                 135                 140                 


Trp Met Ala Arg Val Thr Val Ile Leu Leu Ala Leu Ser Leu Gly Pro 
145                 150                 155                 160 


Val Tyr Ala 
            


<210>  31
<211>  10389
<212>  DNA
<213>  Powassan virus (strain LB)

<400>  31
caagagctgg gagtggttat gatgaccact tctaaaggaa aggggggcgg tccccctagg       60

cgcaagctta aagtgaccgc aaataagtcg cgaccagcaa cgagcccaat gccaaagggc      120

ttcgtgctgt cgcgcatgct ggggattctt tggcacgccg tgacaggcac ggccagaccc      180

ccagtgctga aaatgttctg gaaaacggta ccactgcgcc aggcggaggc tgttctgaag      240

aagataaaga gagttatcgg gaacttgatg cagagcctcc acatgagagg gcgtcgcagg      300

tcaggtgtgg actggacttg gatttttttg acgatggcgt tgatgaccat ggccatggca      360

accaccatcc accgggacag ggaaggatac atggttatgc gggccagtgg aagggacgct      420

gcaagccagg tcagggtaca aaacggaacg tgcgtcatcc tggcaacaga catgggagag      480

tggtgtgaag attcaatcac ctactcttgc gtcacgattg accaggagga agaacccgtt      540

gacgtggact gcttctgccg aggtgttgat agggttaagt tagagtatgg acgctgtgga      600

aggcaagctg gatctagggg gaaaaggtct gtggtcattc caacacatgc acaaaaagac      660

atggtcgggc gaggtcatgc atggcttaaa ggtgacaata ttcgagatca tgtcacccga      720

gtcgagggct ggatgtggaa gaacaagctt ctaactgccg ccattgtggc cttggcttgg      780

ctcatggttg atagttggat ggccagagtg actgtcatcc tcttggcgtt gagtctaggg      840

ccagtgtacg ccacgaggtg cacgcatctt gagaacagag attttgtgac aggaactcaa      900

gggaccacca gagtgtccct agttttggaa cttggaggct gcgtgaccat cacagctgag      960

ggcaagccat ccattgatgt atggctcgaa gacatttttc aggaaagccc ggctgaaacc     1020

agagaatact gcctgcacgc caaattgacc aacacaaaag tggaggctcg ctgtccaacc     1080

actggaccgg cgacacttcc ggaggagcat caggctaata tggtgtgcaa gagagaccaa     1140

agcgaccgtg gatggggaaa ccactgcggg ttttttggga agggcagtat agtggcttgt     1200

gcaaagtttg aatgcgagga agcaaaaaaa gctgtgggcc acgtctatga ctccacaaag     1260

atcacgtatg ttgtcaaggt tgagccccac acaggggatt acttggctgc aaatgagacc     1320

aattcaaaca ggaaatcagc acagtttacg gtggcatccg agaaagtgat cctgcggctc     1380

ggcgactatg gagatgtgtc gctgacgtgt aaagtggcaa gtgggattga tgtcgcccaa     1440

actgtggtga tgtcactcga cagcagcaag gaccacctgc cttctgcatg gcaagtgcac     1500

cgtgactggt ttgaggactt ggcgctgccc tggaaacaca aggacaacca agattggaac     1560

agtgtggaga aacttgtgga atttggacca ccacatgctg tgaaaatgga tgttttcaat     1620

ctgggggacc agacggctgt gctgctcaaa tcactggcag gagttccgct ggccagtgtg     1680

gagggccaga aataccacct gaaaagcggc catgttactt gtgatgtggg actggaaaag     1740

ctgaaactga aaggcacaac ctactccatg tgtgacaaag caaagttcaa atggaagaga     1800

gttcctgtgg acagcggcca tgacacagta gtcatggagg tatcatacac aggaagcgac     1860

aagccatgtc ggatcccggt gcgggctgtg gcacatggtg tcccagcggt taatgtagcc     1920

atgctcataa cccccaatcc aaccattgaa acaaatggtg gcggattcat agaaatgcag     1980

ctgccaccag gggataacat catctatgtg ggagacctta gccagcagtg gtttcagaaa     2040

ggcagtacca ttggtagaat gtttgaaaaa acccgcaggg gattggaaag gctctctgtg     2100

gttggagaac atgcatggga ctttggctca gtaggcgggg tactgtcttc tgtggggaag     2160

gcaatccaca cggtgctggg gggagctttc aacacccttt ttgggggggt tggattcatc     2220

cctaagatgc tgctgggggt tgctctggtc tggttgggac taaatgccag gaatccaacg     2280

atgtccatga cgtttcttgc tgtgggggct ttgacactga tgatgacaat gggagttggg     2340

gcagattatg gatgtgccat tgacccagaa aggatggaaa tccgctgtgg agaagggctt     2400

gttgtgtgga aagaggtgtc ggaatggtat gacggctacg cctatcaccc agaatcacct     2460

gacacgcttg cacaggctct cagagaggcc tttgagagag gcgtttgtgg ggtcgtgccc     2520

caaaacagac ttgaaatggc catgtggaga agcactgctc cggaactcaa cttggtgctg     2580

agtgagggag aagcaaactt gaccatcgtg gtagacaaaa cagatccggc agactatagg     2640

ggaggcactc ccatggttct aaagaagact ggaaaagaga gcaaggtgtc ctggaagagc     2700

tggggcaagt caatcttgtg gagtgttcct gatagcccca ggcgcatgat gatgggggtt     2760

gacggagttg gggagtgccc cttgtatagg agagcaacag gagtgttcac agtggcagag     2820

tttggagtgg gcctacgcac gaaagtgttc ttggatctgc gtggtgaagc ttcaaaagag     2880

tgtgacacag gagtgatggg agcagccgtg aagaatggaa aagccatcca cacggaccaa     2940

agtatgtgga tgagctcctt tcggaatgac acgggcacgt acatccatga gcttattctc     3000

actgatctca ggaactgcac atggccagca agtcacacta ttgataatga tggagtttta     3060

gactcccatc ttttcttgcc agtcaccctt gctgggccca ggtcaaagta caacaggata     3120

cctgggtaca gtgaacaagt aagaggacca tgggaccaga ctcctctgag ggtggtccgg     3180

gaccattgcc ctggaacaag tgtgaggatt gacagccatt gtgacaagag aggagcttca     3240

gttagaagca ccacagaaag tggaaagatc attccagagt ggtgctgccg ggcctgtgag     3300

ctaccaccgg tgacattccg tagtggcacg gattgttggt acgctatgga aatcaggcca     3360

gtccattcgc agggcggctt ggtgcgttcc atggtagtgg ctgacaatgg tgccttgctt     3420

agtgagggag gagttcctgg tctagtggca gtgtttgtat tgatggaatt ccttttgaga     3480

aggcgtccgg gatctgtcac gtccattttg tggggaggca tactaatgct gggcttgctg     3540

gtcacgggtc tcgtgagagt ggaggagatc gtgcgctatg tcatagcagt tggggtcact     3600

ttccacttgg aattgggacc agagaccatg gttcttgtga tgctgcaggc ggtcttcaac     3660

atgcgcacat gttatctcat ggggtttctt gtcaagaggg tgatcaccac acgtgaggtg     3720

gtgactgttt acttcttgct attggtcctt gagatgggga taccggagat gaacttcgga     3780

cacctctggg aatgggctga tgcactggcc atggggttgc tcataatcaa ggccagtgcg     3840

atggaagatc gcagaggttt gggattcttg ctggctgggc tcatgacaca aagacaccta     3900

gtcgctgtcc atcatggttt gatggtattt ctcactgtgg ccttggcggt agtgggacgg     3960

aatatctaca atggacaaaa agagaggaaa ggactgtgtt tcacagtccc cctggcctca     4020

ctacttggtg gctccggctc cggattgcgc atgctggcct tgtgggaatg tcttgggggt     4080

cgtggcagac ggagcctcag tgagcccctt actgtggtgg gggtcatgct ggccatggcc     4140

agtggactac tacgacattc atcccaagag gctcttttgg ccctttctgc aggatccttt     4200

ctcattttga tgctgatcct ggggacccgt agactccagc taacggcgga atgggccgga     4260

gtggtggagt ggaaccctga gttggtcaat gagggaggtg aggtaagctt gaaggtcaga     4320

caggatgcca tggggaactt gcacttgaca gaggtggaac gggaggagcg tcgtttggcc     4380

ttatggcttg tgttcggcct actggcatcg gcttatcatt ggtccggaat attggtcaca     4440

atgggggctt ggacagttta tgagctcttc tcatccacgc ggagaactga cctggttttt     4500

tcagggcagt tgcctgacca aggggaaaaa cgttcctttg acatcaagga aggcgtatac     4560

cgcatatacg cccctgggct cttctggggt taccgccaga taggtgtggg atatggaacg     4620

aaaggagtct tacacaccat gtggcatgtg acaagaggag ccgccctcag cgtggagggg     4680

gccacatcag gaccatactg ggcggatgtg cgtgaagacg tggtctgcta tgggggggcc     4740

tggggcttgg acaaaaaatg gggaggcgaa gtcgttcagg tacacgcatt ccctccggac     4800

agtggacaca aaatccatca atgccagcca ggaaagctga accttgaggg ggggagagtt     4860

ctgggggcca tcccgataga cctcccacgt ggtacttcag gtagcccaat catcaatgca     4920

cagggagatg tgctgggtct gtacggcaat ggtctgaaat caaatgatgt ttacatcagt     4980

agcattgctc agggcaatgt tgaaaagagt cgccctgaga tgccattggc agtccagggt     5040

ggcaaatgga catctaaggg cagcatcaca gttttggata tgcatcccgg gtcgggaaag     5100

acacacagag tccttcccga actgattcgt gagtgcattg acaaaaggtt gaggactgtt     5160

gtattggcgc caacacgggt ggtcctgaag gaaatggaaa gggccttgca ggggaaacgt     5220

gtcaagtttc attcggcagc agttgacaat gcttcttcat catcgggagc tattgttgat     5280

gtcatgtgtc atgccaccta cgtcaaccgc cggctcttgc cacaagggag acagaactgg     5340

gaggtggcca taatggatga ggcacattgg accgacccac acagcatagc tgcccgaggc     5400

catctttact ccttggccaa ggagaacaga tgtgcactcg tgctgatgac tgctacccca     5460

cctggcaaga gcgaggcgtt ccctgaatcc aaaggagcca tagtgagtga ggaaaaaccc     5520

attcccgaag gagagtggag agatggcttt gattggataa cagaatttga gggtcgaaca     5580

gcctggtttg tgccatcgat agccaaggga ggcgccatag cacggacact gagacagaaa     5640

gggaaaagcg tgatctgtct gaacagtaag acctttgaca aggattatgg cagagtccat     5700

gaggaaaaac ctgacttcgt cgtgacaact gacatctcag aaatgggggc caatctagat     5760

gttaatcggg tcatagatgg tagaactaac atcaaacccg aggagataga tggaaaggtg     5820

gaattgattg gcacgagacg agtgacgaca gcatcagctg cgcaacgcag agggcgagtt     5880

ggaaggcatg aaggacgcac ggacctctat gtgtattctg ggcagtgtga tgatgatgac     5940

agctccttag tgcagtggaa agaagcgcag attctgcttg acaacattac tacagtgaga     6000

ggaccagttg ccacttttta tggtccagag caagggaaaa tgctcgaggt ggcggggcac     6060

ttccgcttga cggaggaaaa aagaaagcac ttccggcacc ttctgacaaa ctgtgacttc     6120

acgccctggc tcgcatggca cgtggctgca aacactgcct gtgtgacgga ccggaaatgg     6180

acctgggaag gtcccgacga gaatgccatt gatggtccag gcggcgaact ggtcacgttc     6240

agaagcccca atggagcgga acggaagctg aagccaatct ggaaggacag tagaatgttc     6300

cgggagggga gagatgtggc agacttcatc cagtacgctt ccggtcgtag gagtgccgtg     6360

gacatcctga ctggacttgg tggagtccca gacctgctgc ggttgcgctg cacagcggcg     6420

tgggatgttg tctacacact gctcaatgag accccaggga gtcgcgccat gaaaatggcg     6480

gagagagatg ctcctgaggc gatgctgaca cttttggagg tagcggttct gggcatcgcc     6540

acactggggg tggtttggtg tttcattgtc cggacgtcag tcagcagaat ggttctgggc     6600

accctggtgt tggcagtggc tctcatcctg ttgtggttgg gaggaatgga ctatggaacc     6660

atggcaggag tggctctcat cttctatttg ctcctcacgg tactgcaacc agaaccggga     6720

aagcagcgta gtggagagga taaccgactg gccttcctgt tgattggact ggggagcgtg     6780

gtgggccttg tggcagccaa tgagctgggc tatctggaac aaacgaaaac tgacatttca     6840

ggactcttta gacgtgagga ccagggaggg atggtttggg acgcatggac gaacatcgac     6900

atacagcctg cccgatcctg gggaacttat gtgctcattg tctccctctt tactccatat     6960

atgctccatc agctacaaac aaaaatccag aggctggtga acagctcagt tgcagcggga     7020

acacaggcca tgagagacct tgggggaggc accccattct ttggtgtagc tggacatgtc     7080

gtggcactcg gtgtgacctc tttggtagga gcgacgccca cctcccttgc attgggtgtt     7140

gccttggctg ccctccattt ggccgtggtc acatctgggc tggaggctga actgacccag     7200

agggcgcacc gggcattttt ctcagccatg gtaaagaatc caatggtgga tggagagatc     7260

atcaacccca ttccggatgg agacccaaaa ccagctttgt atgagaggaa gatgagtttg     7320

tttctcgcca tcggcctgtg catagcggcc gtagccttga acaggactgc cgcggcgatg     7380

acagaagctg gcgcagtggc tgtggcggct ttgggacagt tgctgaggcc cgaagaggag     7440

agctggtgga ccatgcccat ggcttgcgga atggctggac tggtgcgggg aagcctatgg     7500

ggcttactgc cagttcttca ccgcatctgg ctcagaaccc agggagctag aaggggtgga     7560

gcagagggaa gcacccttgg tgacatttgg aagcagcggc tgaactcatg caccaaagaa     7620

gaattttttg cctacaggcg cacaggggtc atggagacaa accgagacca agctcgtgaa     7680

ttgcttcgcc gaggtgagac taacatgggg ttggcagtat cgcgaggctg tgccaaacta     7740

gcttggctag aggaaagggg gtacgcgaca ctcaaaggag aggttgtgga ccttggttgt     7800

ggaagggggg gctggtcata ttatgccgcc tcaagaccat ccgtcatggc tgtgagagct     7860

tacaccattg gagggaaggg ccatgaagca ccacgccttg tgacgagtct tggatggaat     7920

ctcataaagt tcaggagtgg gatggatgtg ttctcaatgg cgaccacaag agcagacaca     7980

atcttgtgtg acattgggga gagcagtcca gatccggaga aggaaggggc tcggagccga     8040

agagtgattc ttttgatgga acaatggaaa gccagaaacc cagacgccgc ggcagtcttc     8100

aaggtgttgg ccccgtatag gccagaggtg ctcgaggctc tgcacagatt tcagctacaa     8160

tggggggggg ggcttgtgag agtccctttc tcacggaatt ccacccatga aatgtactat     8220

tccacggccg tcacaggaaa tcttgttaat tcagtcaatg tgctctcgcg gaagctcctg     8280

gctagatttg gggagacgag aggacccatc caggtgcctg agatcgacct gggaactgga     8340

accaggtgtg tgacgctagc tgaggacaaa gtgaagccca gggacgtggc ggagcgcatt     8400

ggagccttga gggaacagta ctcagagtcg tggcacgaag acaaagaaca tccctaccgg     8460

acatggcaat actggggcag ctatcgcact ccggctaccg gatcagcggc atccctgatc     8520

aacggagtgg tgaagctgct aagctggcct tggaatgcac gggaggatgt taccagaatg     8580

gccatgacag acacaacggc ctttgggcag cagcgagttt tcaaagaaaa ggttgacaca     8640

aaggcccaag agccgcagcc aggcaccaga gtgatcatga gagctgtgag tgactggctg     8700

ttggagcatc taagccgccg agccaaagtg aggatgtgta ccaaagatga gttcatagcg     8760

aaggtgaggt ccaacgctgc tctaggtgca tggtcggatg aacagaataa gtggagctcg     8820

gcaaaagagg cagtggaaga tccagaattt tggaaattgg tggatgaaga gcgctccaga     8880

cacttgaaag gtcagtgccg acattgtgtg tacaacatga tgggaaagag agagaagaag     8940

ctaggtgagt ttggagttgc aaaaggcagc agggccatct ggtacatgtg gcttggaagc     9000

cgcttccttg agtttgaggt ccttgggttt cttaatgagg agcattgggc ttccagagag     9060

gtgagtggag ctggggtgga aggaactagt ctcaactatc tgggctggct gctaagagaa     9120

cttggaatga aagacggtgg caaactgtac gccgacgata ccgctggctg ggacactcgg     9180

atcaccaatg cagatttgga agatgaagag cagatccttc ggtacatgga aggagaacac     9240

catgtgctgg caaaaacaat acttgaaaag gcttaccatg ccaaagtggt caaggttgcc     9300

aggccctcac cccaaggggg atgtgtgatg gacgtgatca caaggagaga ccagagggga     9360

tcaggacagg tcgtcacata cgccctcaac accatcacaa acatgaaagt ccaactcatc     9420

cgcatgatgg aaggagaagg agtcatagga ccagctgact cacaggaccc tcgtctgaaa     9480

agggtagaaa cctggttgaa ggagcacgga gttgaaagac tagggaggat gcttgtgagt     9540

ggagatgatt gtgtcgtcaa gcccatcgat gacaggttcg gaaaggcgct gtacttcctg     9600

aatgacatgg ccaaggttcg taaggatgtg ggagagtggg agccctcgat gggcttcaca     9660

gagtgggagg aggtcccttt ctgttcacat cacttccatg aacttgtgat gaaggatgga     9720

cgctctctca tagtgccatg cagagaccaa gatgagctgg ttggcagggc aagggtgtca     9780

ccaggatgtg gatggagtgt gcgagagacg gcctgcctgt ccaaggcgta cgggcagatg     9840

tggcttctca actactttca tcgcagagac cttcgcaccc ttggtttcgc catatgttct     9900

gctgttcccg tgagttgggt tcccatgggt cgcaccactt ggagcatcca cgcgagtggt     9960

gaatggatga caacagaaga catgctgcgc atctggaaca aagtctggat tttggacaac    10020

cctcacatgg aagataagca gacagtggat gagtggagag acatccccta tctgccaaaa    10080

acacaggacc tggtatgttc ctcacttgtt gggagaaagg agagggcaga atgggctaag    10140

aacatctggg gctcagtgga gaaggtcagg aagctcattg gaccagaaga ctacagagac    10200

tacttatcaa gcatggacag acatgacctg cactgggagc tcaagctaga gagctcgata    10260

atctaaacta gcatgactga acagtcaaaa gaaccctaac acaggggatg gtgtggcagc    10320

gcacaacgac atcgtgacgg gagtgggtcg cccccgacgc accatcctct tgggaaaaat    10380

tttcgtgag                                                            10389


<210>  32
<211>  4371
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-ZIKV region with E alone)

<400>  32
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttacttg taaagctcgt ccatgccgag agtgatcccg gcggcggtca      660

cgaactccag caggaccatg tgatcgcgct tctcgttggg gtctttgctc agggcggact      720

gggtgctcag gtagtggttg tcgggcagca gcacggggcc gtcgccgatg ggggtgttct      780

gctggtagtg gtcggcgagc tgcacgctgc cgtcctcgat gttgtggcgg atcttgaagt      840

tcaccttgat gccgttcttc tgcttgtcgg ccatgatata gacgttgtgg ctgttgtagt      900

tgtactccag cttgtgcccc aggatgttgc cgtcctcctt gaagtcgatg cccttcagct      960

cgatgcggtt caccagggtg tcgccctcga acttcacctc ggcgcgggtc ttgtagttgc     1020

cgtcgtcctt gaagaagatg gtgcgctcct ggacgtagcc ttcgggcatg gcggacttga     1080

agaagtcgtg ctgcttcatg tggtcggggt agcggctgaa gcactgcacg ccgtaggtca     1140

gggtggtcac gagggtgggc cagggcacgg gcagcttgcc ggtggtgcag atgaacttca     1200

gggtcagctt gccgtaggtg gcatcgccct cgccctcgcc ggacacgctg aacttgtggc     1260

cgtttacgtc gccgtccagc tcgaccagga tgggcaccac cccggtgaac agctcctcgc     1320

ccttgctcac catactagtt atttatagca tagaaaaaaa caaaatgaaa ttctactata     1380

tagaaaaacc atggttaaga cccactttca catttaagtt gtttttctaa tccgcatatg     1440

atcaattcaa ggccgaataa gaaggctggc tctgcacctt ggtgatcaaa taattcgata     1500

gcttgtcgta ataatggcgg catactatca gtagtaggtg tttccctttc ttctttagcg     1560

acttgatgct cttgatcttc caatacgcaa cctaaagtaa aatgccccac agcgctgagt     1620

gcatataatg cattctctag tgaaaaacct tgttggcaaa gaaaggctaa ttgattttcg     1680

agagtttcat actgtttttc tgtaggccgt gtacctaaat gtacttttgc tccatcgcga     1740

tgacttagta aagcacatct aaaactttta gcgttattac gtaaaaaatc ttgccagctt     1800

tccccttcta aagggcaaaa gtgagtatgg tgcctatcta acatctcaat ggctaaggcg     1860

tcgagcaaag cccgcttatt ttttacatgc caatacaatg taggctgctc tacacctagc     1920

ttctgggcga gtttacgggt tgttaaacct tcgattccga cctcattaag cagctctaat     1980

gcgctgttaa tcactttact tttatctaat ctagacatgc tagctattta tattccaaaa     2040

aaaaaaaata aaatttcaat ttttaactgc agttaaaaat tgaaatttta tttttttttt     2100

ttggaatata aatactcgag atgatcaggt gcataggagt cagcaatagg gactttgtgg     2160

aaggtatgtc aggtgggact tgggttgatg ttgtcttgga acatgggggt tgtgtcaccg     2220

taatggcaca ggacaaacca acagtcgaca tagagctggt tacaacaaca gtcagcaaca     2280

tggcggaggt aagatcctac tgctatgagg catcaatatc agacatggct tcggacagcc     2340

gctgcccaac acaaggtgaa gcctaccttg acaagcaatc agacactcaa tatgtctgca     2400

aaagaacgtt agtggacaga ggctggggaa atggatgtgg actttttggc aaagggagcc     2460

tggtgacatg cgctaagttt gcatgctcca agaaaatgac cgggaagagc atccagccag     2520

agaatctgga gtaccggata atgctgtcag ttcatggctc ccagcacagt gggatgatcg     2580

ttaatgacac aggacatgaa actgatgaga atagagcgaa ggttgagata acgcccaatt     2640

caccaagagc cgaagccacc ctggggggtt ttggaagctt aggacttgat tgtgaaccga     2700

ggacaggcct tgacttttca gatttgtatt acttgactat gaataacaag cactggttgg     2760

ttcacaagga gtggttccac gacattccat taccttggca cgctggggca gacaccggaa     2820

ctccacactg gaacaacaaa gaagcactgg tagagttcaa ggacgcacat gccaaaaggc     2880

aaactgtcgt ggttctaggg actcaagaag gagcagttca cacggccctt gctggagctc     2940

tggaggctga gatggatggt gcaaagggaa ggctgtcctc tggccacttg aaatgtcgcc     3000

tgaaaatgga taaacttaga ttgaagggcg tgtcatactc cttgtgtacc gcagcgttca     3060

cattcaccaa gatcccggct gaaacactgc acgggacagt cacagtggag gtacagtacg     3120

cagggacaga tggaccttgc aaggttccag ctcagatggc ggtggacatg caaactctga     3180

ccccagttgg gaggttgata accgctaacc ccgtaatcac tgaaagcact gagaactcta     3240

agatgatgct ggaacttgat ccaccatttg gggactctta cattgtcata ggagtcgggg     3300

agaagaagat cacccaccac tggcacagga gtggcagcac cattggaaaa gcatttgaag     3360

ccactgtgag aggtgccaag agaatggcag tcttgggaga cacagcctgg gactttggat     3420

cagttggagg cgctctcaac tcattgggca agggcatcca tcaaattttt ggagcagctt     3480

tcaaatcatt gtttggagga atgtcctggt tctcacaaat tctcattgga acgttgctga     3540

tgtggttggg tctgaacaca aagaatggat ctatttccct tatgtgcttg gccttagggg     3600

gagtgttgat cttcttatcc accgcggttt ctgctcatca tcatcaccat cactaaccgc     3660

ggtttctgct taatttttgt ggatcctgta caagtaagca tgcatatatg ctcatatatt     3720

tatagaagat atcacatatc taaatatccc tatcagtgat agagacggcc gatgaatacc     3780

ggaatcatag atttatttga taatcatgtt gatagtatac caactatatt acctcatcag     3840

ttagctactc tagattatct agttagaact atcatagatg agaacagaag cgtgttattg     3900

ttccatatta tgggatcagg taaaacaata atcgctttgt tgttcgcctt ggtagcttcc     3960

agatttaaaa aggtttacat tctagtgcct aatatcaaca ttttgaaaat ttttaattat     4020

aatatgggtg tagctatgaa cttgtttaat gacgaattca tagctgagaa tatctttatt     4080

cattccacaa caagttttta ttctcttaat tataacgata acgtcattaa ttataacgga     4140

ttatctcgct acaataactc tatttttatc gttgatgagg cacataatat ctttgggaat     4200

aatactggag aacttatgac cgtgataaaa aataaaaaca agattccttt tctactattg     4260

tctggatctc ccattactaa cacacctaat actctgggtc atattataga tttaatgtcc     4320

gaagagacga tagattttgg tgagattatt agtcgtggta agaaagtaat t              4371


<210>  33
<211>  4929
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-ZIKV region with wt signal protein)

<400>  33
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttacttg taaagctcgt ccatgccgag agtgatcccg gcggcggtca      660

cgaactccag caggaccatg tgatcgcgct tctcgttggg gtctttgctc agggcggact      720

gggtgctcag gtagtggttg tcgggcagca gcacggggcc gtcgccgatg ggggtgttct      780

gctggtagtg gtcggcgagc tgcacgctgc cgtcctcgat gttgtggcgg atcttgaagt      840

tcaccttgat gccgttcttc tgcttgtcgg ccatgatata gacgttgtgg ctgttgtagt      900

tgtactccag cttgtgcccc aggatgttgc cgtcctcctt gaagtcgatg cccttcagct      960

cgatgcggtt caccagggtg tcgccctcga acttcacctc ggcgcgggtc ttgtagttgc     1020

cgtcgtcctt gaagaagatg gtgcgctcct ggacgtagcc ttcgggcatg gcggacttga     1080

agaagtcgtg ctgcttcatg tggtcggggt agcggctgaa gcactgcacg ccgtaggtca     1140

gggtggtcac gagggtgggc cagggcacgg gcagcttgcc ggtggtgcag atgaacttca     1200

gggtcagctt gccgtaggtg gcatcgccct cgccctcgcc ggacacgctg aacttgtggc     1260

cgtttacgtc gccgtccagc tcgaccagga tgggcaccac cccggtgaac agctcctcgc     1320

ccttgctcac catactagtt atttatagca tagaaaaaaa caaaatgaaa ttctactata     1380

tagaaaaacc atggttaaga cccactttca catttaagtt gtttttctaa tccgcatatg     1440

atcaattcaa ggccgaataa gaaggctggc tctgcacctt ggtgatcaaa taattcgata     1500

gcttgtcgta ataatggcgg catactatca gtagtaggtg tttccctttc ttctttagcg     1560

acttgatgct cttgatcttc caatacgcaa cctaaagtaa aatgccccac agcgctgagt     1620

gcatataatg cattctctag tgaaaaacct tgttggcaaa gaaaggctaa ttgattttcg     1680

agagtttcat actgtttttc tgtaggccgt gtacctaaat gtacttttgc tccatcgcga     1740

tgacttagta aagcacatct aaaactttta gcgttattac gtaaaaaatc ttgccagctt     1800

tccccttcta aagggcaaaa gtgagtatgg tgcctatcta acatctcaat ggctaaggcg     1860

tcgagcaaag cccgcttatt ttttacatgc caatacaatg taggctgctc tacacctagc     1920

ttctgggcga gtttacgggt tgttaaacct tcgattccga cctcattaag cagctctaat     1980

gcgctgttaa tcactttact tttatctaat ctagacatgc tagctattta tattccaaaa     2040

aaaaaaaata aaatttcaat ttttaactgc agttaaaaat tgaaatttta tttttttttt     2100

ttggaatata aatactcgag atgggcgcag atactagtgt cggaatcgtt ggcctcctgc     2160

tgaccacagc tatggcagcg gaggtcacta gacgtgggag tgcatactat atgtacttgg     2220

acagaaacga tgctggggag gccatatctt ttccaaccac attggggatg aataagtgtt     2280

atatacagat catggatctt ggacacatgt gtgatgccac catgagctat gaatgcccta     2340

tgctggatga gggggtggaa ccagatgatg tcgattgttg gtgcaacacg acatcaactt     2400

gggttgtgta cggaacctgc catcacaaaa aaggtgaagc acggagatct agaagagctg     2460

tgacgctccc ctcccattcc actaggaagc tgcaaacgcg gtcgcaaacc tggttggaat     2520

caagagaata cacaaagcac ttgattagag tcgaaaattg gatattcagg aaccctggct     2580

tcgcgttagc agcagctgcc atcgcttggc ttttgggaag ctcaacgagc caaaaagtca     2640

tatacttggt catgatactg ctgattgccc cggcatacag catcaggtgc ataggagtca     2700

gcaataggga ctttgtggaa ggtatgtcag gtgggacttg ggttgatgtt gtcttggaac     2760

atgggggttg tgtcaccgta atggcacagg acaaaccaac agtcgacata gagctggtta     2820

caacaacagt cagcaacatg gcggaggtaa gatcctactg ctatgaggca tcaatatcag     2880

acatggcttc ggacagccgc tgcccaacac aaggtgaagc ctaccttgac aagcaatcag     2940

acactcaata tgtctgcaaa agaacgttag tggacagagg ctggggaaat ggatgtggac     3000

tttttggcaa agggagcctg gtgacatgcg ctaagtttgc atgctccaag aaaatgaccg     3060

ggaagagcat ccagccagag aatctggagt accggataat gctgtcagtt catggctccc     3120

agcacagtgg gatgatcgtt aatgacacag gacatgaaac tgatgagaat agagcgaagg     3180

ttgagataac gcccaattca ccaagagccg aagccaccct ggggggtttt ggaagcttag     3240

gacttgattg tgaaccgagg acaggccttg acttttcaga tttgtattac ttgactatga     3300

ataacaagca ctggttggtt cacaaggagt ggttccacga cattccatta ccttggcacg     3360

ctggggcaga caccggaact ccacactgga acaacaaaga agcactggta gagttcaagg     3420

acgcacatgc caaaaggcaa actgtcgtgg ttctagggac tcaagaagga gcagttcaca     3480

cggcccttgc tggagctctg gaggctgaga tggatggtgc aaagggaagg ctgtcctctg     3540

gccacttgaa atgtcgcctg aaaatggata aacttagatt gaagggcgtg tcatactcct     3600

tgtgtaccgc agcgttcaca ttcaccaaga tcccggctga aacactgcac gggacagtca     3660

cagtggaggt acagtacgca gggacagatg gaccttgcaa ggttccagct cagatggcgg     3720

tggacatgca aactctgacc ccagttggga ggttgataac cgctaacccc gtaatcactg     3780

aaagcactga gaactctaag atgatgctgg aacttgatcc accatttggg gactcttaca     3840

ttgtcatagg agtcggggag aagaagatca cccaccactg gcacaggagt ggcagcacca     3900

ttggaaaagc atttgaagcc actgtgagag gtgccaagag aatggcagtc ttgggagaca     3960

cagcctggga ctttggatca gttggaggcg ctctcaactc attgggcaag ggcatccatc     4020

aaatttttgg agcagctttc aaatcattgt ttggaggaat gtcctggttc tcacaaattc     4080

tcattggaac gttgctgatg tggttgggtc tgaacacaaa gaatggatct atttccctta     4140

tgtgcttggc cttaggggga gtgttgatct tcttatccac cgcggtttct gctcatcatc     4200

atcaccatca ctaaccgcgg tttctgctta atttttgtgg atcctgtaca agtaagcatg     4260

catatatgct catatattta tagaagatat cacatatcta aatatcccta tcagtgatag     4320

agacggccga tgaataccgg aatcatagat ttatttgata atcatgttga tagtatacca     4380

actatattac ctcatcagtt agctactcta gattatctag ttagaactat catagatgag     4440

aacagaagcg tgttattgtt ccatattatg ggatcaggta aaacaataat cgctttgttg     4500

ttcgccttgg tagcttccag atttaaaaag gtttacattc tagtgcctaa tatcaacatt     4560

ttgaaaattt ttaattataa tatgggtgta gctatgaact tgtttaatga cgaattcata     4620

gctgagaata tctttattca ttccacaaca agtttttatt ctcttaatta taacgataac     4680

gtcattaatt ataacggatt atctcgctac aataactcta tttttatcgt tgatgaggca     4740

cataatatct ttgggaataa tactggagaa cttatgaccg tgataaaaaa taaaaacaag     4800

attccttttc tactattgtc tggatctccc attactaaca cacctaatac tctgggtcat     4860

attatagatt taatgtccga agagacgata gattttggtg agattattag tcgtggtaag     4920

aaagtaatt                                                             4929


<210>  34
<211>  4929
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-ZIKV region with D4W SP sequence)

<400>  34
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttacttg taaagctcgt ccatgccgag agtgatcccg gcggcggtca      660

cgaactccag caggaccatg tgatcgcgct tctcgttggg gtctttgctc agggcggact      720

gggtgctcag gtagtggttg tcgggcagca gcacggggcc gtcgccgatg ggggtgttct      780

gctggtagtg gtcggcgagc tgcacgctgc cgtcctcgat gttgtggcgg atcttgaagt      840

tcaccttgat gccgttcttc tgcttgtcgg ccatgatata gacgttgtgg ctgttgtagt      900

tgtactccag cttgtgcccc aggatgttgc cgtcctcctt gaagtcgatg cccttcagct      960

cgatgcggtt caccagggtg tcgccctcga acttcacctc ggcgcgggtc ttgtagttgc     1020

cgtcgtcctt gaagaagatg gtgcgctcct ggacgtagcc ttcgggcatg gcggacttga     1080

agaagtcgtg ctgcttcatg tggtcggggt agcggctgaa gcactgcacg ccgtaggtca     1140

gggtggtcac gagggtgggc cagggcacgg gcagcttgcc ggtggtgcag atgaacttca     1200

gggtcagctt gccgtaggtg gcatcgccct cgccctcgcc ggacacgctg aacttgtggc     1260

cgtttacgtc gccgtccagc tcgaccagga tgggcaccac cccggtgaac agctcctcgc     1320

ccttgctcac catactagtt atttatagca tagaaaaaaa caaaatgaaa ttctactata     1380

tagaaaaacc atggttaaga cccactttca catttaagtt gtttttctaa tccgcatatg     1440

atcaattcaa ggccgaataa gaaggctggc tctgcacctt ggtgatcaaa taattcgata     1500

gcttgtcgta ataatggcgg catactatca gtagtaggtg tttccctttc ttctttagcg     1560

acttgatgct cttgatcttc caatacgcaa cctaaagtaa aatgccccac agcgctgagt     1620

gcatataatg cattctctag tgaaaaacct tgttggcaaa gaaaggctaa ttgattttcg     1680

agagtttcat actgtttttc tgtaggccgt gtacctaaat gtacttttgc tccatcgcga     1740

tgacttagta aagcacatct aaaactttta gcgttattac gtaaaaaatc ttgccagctt     1800

tccccttcta aagggcaaaa gtgagtatgg tgcctatcta acatctcaat ggctaaggcg     1860

tcgagcaaag cccgcttatt ttttacatgc caatacaatg taggctgctc tacacctagc     1920

ttctgggcga gtttacgggt tgttaaacct tcgattccga cctcattaag cagctctaat     1980

gcgctgttaa tcactttact tttatctaat ctagacatgc tagctattta tattccaaaa     2040

aaaaaaaata aaatttcaat ttttaactgc agttaaaaat tgaaatttta tttttttttt     2100

ttggaatata aatactcgag atgggcgcat ggactagtgt cggaatcgtt ggcctcctgc     2160

tgaccacagc tatggcagcg gaggtcacta gacgtgggag tgcatactat atgtacttgg     2220

acagaaacga tgctggggag gccatatctt ttccaaccac attggggatg aataagtgtt     2280

atatacagat catggatctt ggacacatgt gtgatgccac catgagctat gaatgcccta     2340

tgctggatga gggggtggaa ccagatgatg tcgattgttg gtgcaacacg acatcaactt     2400

gggttgtgta cggaacctgc catcacaaaa aaggtgaagc acggagatct agaagagctg     2460

tgacgctccc ctcccattcc actaggaagc tgcaaacgcg gtcgcaaacc tggttggaat     2520

caagagaata cacaaagcac ttgattagag tcgaaaattg gatattcagg aaccctggct     2580

tcgcgttagc agcagctgcc atcgcttggc ttttgggaag ctcaacgagc caaaaagtca     2640

tatacttggt catgatactg ctgattgccc cggcatacag catcaggtgc ataggagtca     2700

gcaataggga ctttgtggaa ggtatgtcag gtgggacttg ggttgatgtt gtcttggaac     2760

atgggggttg tgtcaccgta atggcacagg acaaaccaac agtcgacata gagctggtta     2820

caacaacagt cagcaacatg gcggaggtaa gatcctactg ctatgaggca tcaatatcag     2880

acatggcttc ggacagccgc tgcccaacac aaggtgaagc ctaccttgac aagcaatcag     2940

acactcaata tgtctgcaaa agaacgttag tggacagagg ctggggaaat ggatgtggac     3000

tttttggcaa agggagcctg gtgacatgcg ctaagtttgc atgctccaag aaaatgaccg     3060

ggaagagcat ccagccagag aatctggagt accggataat gctgtcagtt catggctccc     3120

agcacagtgg gatgatcgtt aatgacacag gacatgaaac tgatgagaat agagcgaagg     3180

ttgagataac gcccaattca ccaagagccg aagccaccct ggggggtttt ggaagcttag     3240

gacttgattg tgaaccgagg acaggccttg acttttcaga tttgtattac ttgactatga     3300

ataacaagca ctggttggtt cacaaggagt ggttccacga cattccatta ccttggcacg     3360

ctggggcaga caccggaact ccacactgga acaacaaaga agcactggta gagttcaagg     3420

acgcacatgc caaaaggcaa actgtcgtgg ttctagggac tcaagaagga gcagttcaca     3480

cggcccttgc tggagctctg gaggctgaga tggatggtgc aaagggaagg ctgtcctctg     3540

gccacttgaa atgtcgcctg aaaatggata aacttagatt gaagggcgtg tcatactcct     3600

tgtgtaccgc agcgttcaca ttcaccaaga tcccggctga aacactgcac gggacagtca     3660

cagtggaggt acagtacgca gggacagatg gaccttgcaa ggttccagct cagatggcgg     3720

tggacatgca aactctgacc ccagttggga ggttgataac cgctaacccc gtaatcactg     3780

aaagcactga gaactctaag atgatgctgg aacttgatcc accatttggg gactcttaca     3840

ttgtcatagg agtcggggag aagaagatca cccaccactg gcacaggagt ggcagcacca     3900

ttggaaaagc atttgaagcc actgtgagag gtgccaagag aatggcagtc ttgggagaca     3960

cagcctggga ctttggatca gttggaggcg ctctcaactc attgggcaag ggcatccatc     4020

aaatttttgg agcagctttc aaatcattgt ttggaggaat gtcctggttc tcacaaattc     4080

tcattggaac gttgctgatg tggttgggtc tgaacacaaa gaatggatct atttccctta     4140

tgtgcttggc cttaggggga gtgttgatct tcttatccac cgcggtttct gctcatcatc     4200

atcaccatca ctaaccgcgg tttctgctta atttttgtgg atcctgtaca agtaagcatg     4260

catatatgct catatattta tagaagatat cacatatcta aatatcccta tcagtgatag     4320

agacggccga tgaataccgg aatcatagat ttatttgata atcatgttga tagtatacca     4380

actatattac ctcatcagtt agctactcta gattatctag ttagaactat catagatgag     4440

aacagaagcg tgttattgtt ccatattatg ggatcaggta aaacaataat cgctttgttg     4500

ttcgccttgg tagcttccag atttaaaaag gtttacattc tagtgcctaa tatcaacatt     4560

ttgaaaattt ttaattataa tatgggtgta gctatgaact tgtttaatga cgaattcata     4620

gctgagaata tctttattca ttccacaaca agtttttatt ctcttaatta taacgataac     4680

gtcattaatt ataacggatt atctcgctac aataactcta tttttatcgt tgatgaggca     4740

cataatatct ttgggaataa tactggagaa cttatgaccg tgataaaaaa taaaaacaag     4800

attccttttc tactattgtc tggatctccc attactaaca cacctaatac tctgggtcat     4860

attatagatt taatgtccga agagacgata gattttggtg agattattag tcgtggtaag     4920

aaagtaatt                                                             4929


<210>  35
<211>  4929
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-ZIKV regions with D4K SP)

<400>  35
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttacttg taaagctcgt ccatgccgag agtgatcccg gcggcggtca      660

cgaactccag caggaccatg tgatcgcgct tctcgttggg gtctttgctc agggcggact      720

gggtgctcag gtagtggttg tcgggcagca gcacggggcc gtcgccgatg ggggtgttct      780

gctggtagtg gtcggcgagc tgcacgctgc cgtcctcgat gttgtggcgg atcttgaagt      840

tcaccttgat gccgttcttc tgcttgtcgg ccatgatata gacgttgtgg ctgttgtagt      900

tgtactccag cttgtgcccc aggatgttgc cgtcctcctt gaagtcgatg cccttcagct      960

cgatgcggtt caccagggtg tcgccctcga acttcacctc ggcgcgggtc ttgtagttgc     1020

cgtcgtcctt gaagaagatg gtgcgctcct ggacgtagcc ttcgggcatg gcggacttga     1080

agaagtcgtg ctgcttcatg tggtcggggt agcggctgaa gcactgcacg ccgtaggtca     1140

gggtggtcac gagggtgggc cagggcacgg gcagcttgcc ggtggtgcag atgaacttca     1200

gggtcagctt gccgtaggtg gcatcgccct cgccctcgcc ggacacgctg aacttgtggc     1260

cgtttacgtc gccgtccagc tcgaccagga tgggcaccac cccggtgaac agctcctcgc     1320

ccttgctcac catactagtt atttatagca tagaaaaaaa caaaatgaaa ttctactata     1380

tagaaaaacc atggttaaga cccactttca catttaagtt gtttttctaa tccgcatatg     1440

atcaattcaa ggccgaataa gaaggctggc tctgcacctt ggtgatcaaa taattcgata     1500

gcttgtcgta ataatggcgg catactatca gtagtaggtg tttccctttc ttctttagcg     1560

acttgatgct cttgatcttc caatacgcaa cctaaagtaa aatgccccac agcgctgagt     1620

gcatataatg cattctctag tgaaaaacct tgttggcaaa gaaaggctaa ttgattttcg     1680

agagtttcat actgtttttc tgtaggccgt gtacctaaat gtacttttgc tccatcgcga     1740

tgacttagta aagcacatct aaaactttta gcgttattac gtaaaaaatc ttgccagctt     1800

tccccttcta aagggcaaaa gtgagtatgg tgcctatcta acatctcaat ggctaaggcg     1860

tcgagcaaag cccgcttatt ttttacatgc caatacaatg taggctgctc tacacctagc     1920

ttctgggcga gtttacgggt tgttaaacct tcgattccga cctcattaag cagctctaat     1980

gcgctgttaa tcactttact tttatctaat ctagacatgc tagctattta tattccaaaa     2040

aaaaaaaata aaatttcaat ttttaactgc agttaaaaat tgaaatttta tttttttttt     2100

ttggaatata aatactcgag atgggcgcaa agactagtgt cggaatcgtt ggcctcctgc     2160

tgaccacagc tatggcagcg gaggtcacta gacgtgggag tgcatactat atgtacttgg     2220

acagaaacga tgctggggag gccatatctt ttccaaccac attggggatg aataagtgtt     2280

atatacagat catggatctt ggacacatgt gtgatgccac catgagctat gaatgcccta     2340

tgctggatga gggggtggaa ccagatgatg tcgattgttg gtgcaacacg acatcaactt     2400

gggttgtgta cggaacctgc catcacaaaa aaggtgaagc acggagatct agaagagctg     2460

tgacgctccc ctcccattcc actaggaagc tgcaaacgcg gtcgcaaacc tggttggaat     2520

caagagaata cacaaagcac ttgattagag tcgaaaattg gatattcagg aaccctggct     2580

tcgcgttagc agcagctgcc atcgcttggc ttttgggaag ctcaacgagc caaaaagtca     2640

tatacttggt catgatactg ctgattgccc cggcatacag catcaggtgc ataggagtca     2700

gcaataggga ctttgtggaa ggtatgtcag gtgggacttg ggttgatgtt gtcttggaac     2760

atgggggttg tgtcaccgta atggcacagg acaaaccaac agtcgacata gagctggtta     2820

caacaacagt cagcaacatg gcggaggtaa gatcctactg ctatgaggca tcaatatcag     2880

acatggcttc ggacagccgc tgcccaacac aaggtgaagc ctaccttgac aagcaatcag     2940

acactcaata tgtctgcaaa agaacgttag tggacagagg ctggggaaat ggatgtggac     3000

tttttggcaa agggagcctg gtgacatgcg ctaagtttgc atgctccaag aaaatgaccg     3060

ggaagagcat ccagccagag aatctggagt accggataat gctgtcagtt catggctccc     3120

agcacagtgg gatgatcgtt aatgacacag gacatgaaac tgatgagaat agagcgaagg     3180

ttgagataac gcccaattca ccaagagccg aagccaccct ggggggtttt ggaagcttag     3240

gacttgattg tgaaccgagg acaggccttg acttttcaga tttgtattac ttgactatga     3300

ataacaagca ctggttggtt cacaaggagt ggttccacga cattccatta ccttggcacg     3360

ctggggcaga caccggaact ccacactgga acaacaaaga agcactggta gagttcaagg     3420

acgcacatgc caaaaggcaa actgtcgtgg ttctagggac tcaagaagga gcagttcaca     3480

cggcccttgc tggagctctg gaggctgaga tggatggtgc aaagggaagg ctgtcctctg     3540

gccacttgaa atgtcgcctg aaaatggata aacttagatt gaagggcgtg tcatactcct     3600

tgtgtaccgc agcgttcaca ttcaccaaga tcccggctga aacactgcac gggacagtca     3660

cagtggaggt acagtacgca gggacagatg gaccttgcaa ggttccagct cagatggcgg     3720

tggacatgca aactctgacc ccagttggga ggttgataac cgctaacccc gtaatcactg     3780

aaagcactga gaactctaag atgatgctgg aacttgatcc accatttggg gactcttaca     3840

ttgtcatagg agtcggggag aagaagatca cccaccactg gcacaggagt ggcagcacca     3900

ttggaaaagc atttgaagcc actgtgagag gtgccaagag aatggcagtc ttgggagaca     3960

cagcctggga ctttggatca gttggaggcg ctctcaactc attgggcaag ggcatccatc     4020

aaatttttgg agcagctttc aaatcattgt ttggaggaat gtcctggttc tcacaaattc     4080

tcattggaac gttgctgatg tggttgggtc tgaacacaaa gaatggatct atttccctta     4140

tgtgcttggc cttaggggga gtgttgatct tcttatccac cgcggtttct gctcatcatc     4200

atcaccatca ctaaccgcgg tttctgctta atttttgtgg atcctgtaca agtaagcatg     4260

catatatgct catatattta tagaagatat cacatatcta aatatcccta tcagtgatag     4320

agacggccga tgaataccgg aatcatagat ttatttgata atcatgttga tagtatacca     4380

actatattac ctcatcagtt agctactcta gattatctag ttagaactat catagatgag     4440

aacagaagcg tgttattgtt ccatattatg ggatcaggta aaacaataat cgctttgttg     4500

ttcgccttgg tagcttccag atttaaaaag gtttacattc tagtgcctaa tatcaacatt     4560

ttgaaaattt ttaattataa tatgggtgta gctatgaact tgtttaatga cgaattcata     4620

gctgagaata tctttattca ttccacaaca agtttttatt ctcttaatta taacgataac     4680

gtcattaatt ataacggatt atctcgctac aataactcta tttttatcgt tgatgaggca     4740

cataatatct ttgggaataa tactggagaa cttatgaccg tgataaaaaa taaaaacaag     4800

attccttttc tactattgtc tggatctccc attactaaca cacctaatac tctgggtcat     4860

attatagatt taatgtccga agagacgata gattttggtg agattattag tcgtggtaag     4920

aaagtaatt                                                             4929


<210>  36
<211>  4941
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-ZIKV region JEV construct)

<400>  36
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttacttg taaagctcgt ccatgccgag agtgatcccg gcggcggtca      660

cgaactccag caggaccatg tgatcgcgct tctcgttggg gtctttgctc agggcggact      720

gggtgctcag gtagtggttg tcgggcagca gcacggggcc gtcgccgatg ggggtgttct      780

gctggtagtg gtcggcgagc tgcacgctgc cgtcctcgat gttgtggcgg atcttgaagt      840

tcaccttgat gccgttcttc tgcttgtcgg ccatgatata gacgttgtgg ctgttgtagt      900

tgtactccag cttgtgcccc aggatgttgc cgtcctcctt gaagtcgatg cccttcagct      960

cgatgcggtt caccagggtg tcgccctcga acttcacctc ggcgcgggtc ttgtagttgc     1020

cgtcgtcctt gaagaagatg gtgcgctcct ggacgtagcc ttcgggcatg gcggacttga     1080

agaagtcgtg ctgcttcatg tggtcggggt agcggctgaa gcactgcacg ccgtaggtca     1140

gggtggtcac gagggtgggc cagggcacgg gcagcttgcc ggtggtgcag atgaacttca     1200

gggtcagctt gccgtaggtg gcatcgccct cgccctcgcc ggacacgctg aacttgtggc     1260

cgtttacgtc gccgtccagc tcgaccagga tgggcaccac cccggtgaac agctcctcgc     1320

ccttgctcac catactagtt atttatagca tagaaaaaaa caaaatgaaa ttctactata     1380

tagaaaaacc atggttaaga cccactttca catttaagtt gtttttctaa tccgcatatg     1440

atcaattcaa ggccgaataa gaaggctggc tctgcacctt ggtgatcaaa taattcgata     1500

gcttgtcgta ataatggcgg catactatca gtagtaggtg tttccctttc ttctttagcg     1560

acttgatgct cttgatcttc caatacgcaa cctaaagtaa aatgccccac agcgctgagt     1620

gcatataatg cattctctag tgaaaaacct tgttggcaaa gaaaggctaa ttgattttcg     1680

agagtttcat actgtttttc tgtaggccgt gtacctaaat gtacttttgc tccatcgcga     1740

tgacttagta aagcacatct aaaactttta gcgttattac gtaaaaaatc ttgccagctt     1800

tccccttcta aagggcaaaa gtgagtatgg tgcctatcta acatctcaat ggctaaggcg     1860

tcgagcaaag cccgcttatt ttttacatgc caatacaatg taggctgctc tacacctagc     1920

ttctgggcga gtttacgggt tgttaaacct tcgattccga cctcattaag cagctctaat     1980

gcgctgttaa tcactttact tttatctaat ctagacatgc tagctattta tattccaaaa     2040

aaaaaaaata aaatttcaat ttttaactgc agttaaaaat tgaaatttta tttttttttt     2100

ttggaatata aatactcgag atgggtggaa acgaaggttc aattatgtgg cttgcaagtt     2160

tggctgtagt tattgcgtgc gcaggagcgg cggaggtcac tagacgtggg agtgcatact     2220

atatgtactt ggacagaaac gatgctgggg aggccatatc ttttccaacc acattgggga     2280

tgaataagtg ttatatacag atcatggatc ttggacacat gtgtgatgcc accatgagct     2340

atgaatgccc tatgctggat gagggggtgg aaccagatga tgtcgattgt tggtgcaaca     2400

cgacatcaac ttgggttgtg tacggaacct gccatcacaa aaaaggtgaa gcacggagat     2460

ctagaagagc tgtgacgctc ccctcccatt ccactaggaa gctgcaaacg cggtcgcaaa     2520

cctggttgga atcaagagaa tacacaaagc acttgattag agtcgaaaat tggatattca     2580

ggaaccctgg cttcgcgtta gcagcagctg ccatcgcttg gcttttggga agctcaacga     2640

gccaaaaagt catatacttg gtcatgatac tgctgattgc cccggcatac agcatcaggt     2700

gcataggagt cagcaatagg gactttgtgg aaggtatgtc aggtgggact tgggttgatg     2760

ttgtcttgga acatgggggt tgtgtcaccg taatggcaca ggacaaacca acagtcgaca     2820

tagagctggt tacaacaaca gtcagcaaca tggcggaggt aagatcctac tgctatgagg     2880

catcaatatc agacatggct tcggacagcc gctgcccaac acaaggtgaa gcctaccttg     2940

acaagcaatc agacactcaa tatgtctgca aaagaacgtt agtggacaga ggctggggaa     3000

atggatgtgg actttttggc aaagggagcc tggtgacatg cgctaagttt gcatgctcca     3060

agaaaatgac cgggaagagc atccagccag agaatctgga gtaccggata atgctgtcag     3120

ttcatggctc ccagcacagt gggatgatcg ttaatgacac aggacatgaa actgatgaga     3180

atagagcgaa ggttgagata acgcccaatt caccaagagc cgaagccacc ctggggggtt     3240

ttggaagctt aggacttgat tgtgaaccga ggacaggcct tgacttttca gatttgtatt     3300

acttgactat gaataacaag cactggttgg ttcacaagga gtggttccac gacattccat     3360

taccttggca cgctggggca gacaccggaa ctccacactg gaacaacaaa gaagcactgg     3420

tagagttcaa ggacgcacat gccaaaaggc aaactgtcgt ggttctaggg actcaagaag     3480

gagcagttca cacggccctt gctggagctc tggaggctga gatggatggt gcaaagggaa     3540

ggctgtcctc tggccacttg aaatgtcgcc tgaaaatgga taaacttaga ttgaagggcg     3600

tgtcatactc cttgtgtacc gcagcgttca cattcaccaa gatcccggct gaaacactgc     3660

acgggacagt cacagtggag gtacagtacg cagggacaga tggaccttgc aaggttccag     3720

ctcagatggc ggtggacatg caaactctga ccccagttgg gaggttgata accgctaacc     3780

ccgtaatcac tgaaagcact gagaactcta agatgatgct ggaacttgat ccaccatttg     3840

gggactctta cattgtcata ggagtcgggg agaagaagat cacccaccac tggcacagga     3900

gtggcagcac cattggaaaa gcatttgaag ccactgtgag aggtgccaag agaatggcag     3960

tcttgggaga cacagcctgg gactttggat cagttggagg cgctctcaac tcattgggca     4020

agggcatcca tcaaattttt ggagcagctt tcaaatcatt gtttggagga atgtcctggt     4080

tctcacaaat tctcattgga acgttgctga tgtggttggg tctgaacaca aagaatggat     4140

ctatttccct tatgtgcttg gccttagggg gagtgttgat cttcttatcc accgcggttt     4200

ctgctcatca tcatcaccat cactaaccgc ggtttctgct taatttttgt ggatcctgta     4260

caagtaagca tgcatatatg ctcatatatt tatagaagat atcacatatc taaatatccc     4320

tatcagtgat agagacggcc gatgaatacc ggaatcatag atttatttga taatcatgtt     4380

gatagtatac caactatatt acctcatcag ttagctactc tagattatct agttagaact     4440

atcatagatg agaacagaag cgtgttattg ttccatatta tgggatcagg taaaacaata     4500

atcgctttgt tgttcgcctt ggtagcttcc agatttaaaa aggtttacat tctagtgcct     4560

aatatcaaca ttttgaaaat ttttaattat aatatgggtg tagctatgaa cttgtttaat     4620

gacgaattca tagctgagaa tatctttatt cattccacaa caagttttta ttctcttaat     4680

tataacgata acgtcattaa ttataacgga ttatctcgct acaataactc tatttttatc     4740

gttgatgagg cacataatat ctttgggaat aatactggag aacttatgac cgtgataaaa     4800

aataaaaaca agattccttt tctactattg tctggatctc ccattactaa cacacctaat     4860

actctgggtc atattataga tttaatgtcc gaagagacga tagattttgg tgagattatt     4920

agtcgtggta agaaagtaat t                                               4941


<210>  37
<211>  4829
<212>  DNA
<213>  artificial sequene

<220>
<223>  synthetic construct (vIND-POWV natural SP)

<400>  37
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttaagac ccactttcac atttaagttg tttttctaat ccgcatatga      660

tcaattcaag gccgaataag aaggctggct ctgcaccttg gtgatcaaat aattcgatag      720

cttgtcgtaa taatggcggc atactatcag tagtaggtgt ttccctttct tctttagcga      780

cttgatgctc ttgatcttcc aatacgcaac ctaaagtaaa atgccccaca gcgctgagtg      840

catataatgc attctctagt gaaaaacctt gttggcaaag aaaggctaat tgattttcga      900

gagtttcata ctgtttttct gtaggccgtg tacctaaatg tacttttgct ccatcgcgat      960

gacttagtaa agcacatcta aaacttttag cgttattacg taaaaaatct tgccagcttt     1020

ccccttctaa agggcaaaag tgagtatggt gcctatctaa catctcaatg gctaaggcgt     1080

cgagcaaagc ccgcttattt tttacatgcc aatacaatgt aggctgctct acacctagct     1140

tctgggcgag tttacgggtt gttaaacctt cgattccgac ctcattaagc agctctaatg     1200

cgctgttaat cactttactt ttatctaatc tagacatgct agctatttat attccaaaaa     1260

aaaaaaataa aatttcaatt tttaactgca gttaaaaatt gaaattttat tttttttttt     1320

tggaatataa ataatgaggt caggtgtgga ctggacttgg attttcttga cgatggcgtt     1380

gatgaccatg gccatggcaa ccaccatcca ccgggacagg gaaggataca tggttatgcg     1440

ggccagtgga agggacgctg caagccaggt cagggtacaa aacggaacgt gcgtcatcct     1500

ggcaacagac atgggagagt ggtgtgaaga ttcaatcacc tactcttgcg tcacgattga     1560

ccaggaggaa gaacccgttg acgtggactg cttctgccga ggtgttgata gggttaagtt     1620

agagtatgga cgctgtggaa ggcaagctgg atctaggggg aaaaggtctg tggtcattcc     1680

aacacatgca caaaaagaca tggtcgggcg aggtcatgca tggcttaaag gtgacaatat     1740

tcgagatcat gtcacccgag tcgagggctg gatgtggaag aacaagcttc taactgccgc     1800

cattgtggcc ttggcttggc tcatggttga tagttggatg gccagagtga ctgtcatcct     1860

cttggcgttg agtctagggc cagtgtacgc cacgaggtgc acgcatcttg agaacagaga     1920

ttttgtgaca ggaactcaag ggaccaccag agtgtcacta gttttggaac ttggaggctg     1980

cgtgaccatc acagctgagg gcaagccatc cattgatgta tggctcgaag acatttttca     2040

ggaaagcccg gctgaaacca gagaatactg cctgcacgcc aaattgacca acacaaaagt     2100

ggaggctcgc tgtccaacca ctggaccggc gacacttccg gaggagcatc aggctaatat     2160

ggtgtgcaag agagaccaaa gcgaccgtgg atggggaaac cactgcgggt tttttgggaa     2220

gggcagtata gtggcttgtg caaagtttga atgcgaggaa gcaaaaaaag ctgtgggcca     2280

cgtctatgac tccacaaaga tcacgtatgt tgtcaaggtt gagccccaca caggggatta     2340

cttggctgca aatgagacca attcaaacag gaaatcagca cagtttacgg tggcatccga     2400

gaaagtgatc ctgcggctcg gcgactatgg agatgtgtcg ctgacgtgta aagtggcaag     2460

tgggattgat gtcgcccaaa ctgtggtgat gtcactcgac agcagcaagg accacctgcc     2520

ttctgcatgg caagtgcacc gtgactggtt tgaggacttg gcgctgccct ggaaacacaa     2580

ggacaaccaa gattggaaca gtgtggagaa acttgtggaa tttggaccac cacatgctgt     2640

gaaaatggat gttttcaatc tgggggacca gacggctgtg ctgctcaaat cactggcagg     2700

agttccgctg gccagtgtgg agggccagaa ataccacctg aaaagcggcc atgttacttg     2760

tgatgtggga ctggaaaagc tgaaactgaa aggcacaacc tactccatgt gtgacaaagc     2820

aaagttcaaa tggaagagag ttcctgtgga cagcggccat gacacagtag tcatggaggt     2880

atcatacaca ggaagcgaca agccatgtcg gatcccggtg cgggctgtgg cacatggtgt     2940

cccagcggtt aatgtagcca tgctcataac ccccaatcca accattgaaa caaatggtgg     3000

cggattcata gaaatgcagc tgccaccagg ggataacatc atctatgtgg gagaccttag     3060

ccagcagtgg tttcagaaag gcagtaccat tggtagaatg tttgaaaaaa cccgcagggg     3120

attggaaagg ctctctgtgg ttggagaaca tgcatgggac tttggctcag taggcggggt     3180

actgtcttct gtggggaagg caatccacac ggtgctgggg ggagctttca acaccctttt     3240

tgggggggtt ggattcatcc ctaagatgct gctgggggtt gctctggtct ggttgggact     3300

aaatgccagg aatccaacga tgtccatgac gtttcttgct gtgggggctt tgacactgat     3360

gatgacaatg ggagttgggg cataaaattg gatcagcttt tttttttttt tttttggcat     3420

ataaataagg tcgaagcttg gtaccaaaaa ttgaaaaact attctaattt attgcacatg     3480

gcctcctccg aggacgtcat caaagagttc atgcgcttca aggtgcgcat ggagggctcc     3540

gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc     3600

cagaccgcca agctgaaggt gaccaagggc ggccccctgc ccttcgcctg ggacatcctg     3660

tccccccagt tccagtacgg ctccaaggtg tacgtgaagc accccgccga catccccgac     3720

tacaagaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac     3780

ggcggcgtgg tgaccgtgac ccaggactcc tccctccagg acggctcctt catctacaag     3840

gtgaagttca tcggcgtgaa cttcccctcc gacggccccg taatgcagaa gaagactatg     3900

ggctgggagg cctccaccga gcgcctgtac ccccgcgacg gcgtgctgaa gggcgagatc     3960

cacaaggccc tgaagctgaa ggacggcggc cactacctgg tggagttcaa gtccatctac     4020

atggccaaga agcccgtgca gctgcccggc tactactacg tggactccaa gctggacatc     4080

acctcccaca acgaggacta caccatcgtg gagcagtacg agcgcgccga gggccgccac     4140

cacctgttcc tgtaggcatg catatatgct catatattta tagaagatat cacatatcta     4200

aatatcccta tcagtgatag agacggccga tgaataccgg aatcatagat ttatttgata     4260

atcatgttga tagtatacca actatattac ctcatcagtt agctactcta gattatctag     4320

ttagaactat catagatgag aacagaagcg tgttattgtt ccatattatg ggatcaggta     4380

aaacaataat cgctttgttg ttcgccttgg tagcttccag atttaaaaag gtttacattc     4440

tagtgcctaa tatcaacatt ttgaaaattt ttaattataa tatgggtgta gctatgaact     4500

tgtttaatga cgaattcata gctgagaata tctttattca ttccacaaca agtttttatt     4560

ctcttaatta taacgataac gtcattaatt ataacggatt atctcgctac aataactcta     4620

tttttatcgt tgatgaggca cataatatct ttgggaataa tactggagaa cttatgaccg     4680

tgataaaaaa taaaaacaag attccttttc tactattgtc tggatctccc attactaaca     4740

cacctaatac tctgggtcat attatagatt taatgtccga agagacgata gattttggtg     4800

agattattag tcgtggtaag aaagtaatt                                       4829


<210>  38
<211>  4829
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-POWV D6W SP)

<400>  38
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttaagac ccactttcac atttaagttg tttttctaat ccgcatatga      660

tcaattcaag gccgaataag aaggctggct ctgcaccttg gtgatcaaat aattcgatag      720

cttgtcgtaa taatggcggc atactatcag tagtaggtgt ttccctttct tctttagcga      780

cttgatgctc ttgatcttcc aatacgcaac ctaaagtaaa atgccccaca gcgctgagtg      840

catataatgc attctctagt gaaaaacctt gttggcaaag aaaggctaat tgattttcga      900

gagtttcata ctgtttttct gtaggccgtg tacctaaatg tacttttgct ccatcgcgat      960

gacttagtaa agcacatcta aaacttttag cgttattacg taaaaaatct tgccagcttt     1020

ccccttctaa agggcaaaag tgagtatggt gcctatctaa catctcaatg gctaaggcgt     1080

cgagcaaagc ccgcttattt tttacatgcc aatacaatgt aggctgctct acacctagct     1140

tctgggcgag tttacgggtt gttaaacctt cgattccgac ctcattaagc agctctaatg     1200

cgctgttaat cactttactt ttatctaatc tagacatgct agctatttat attccaaaaa     1260

aaaaaaataa aatttcaatt tttaactgca gttaaaaatt gaaattttat tttttttttt     1320

tggaatataa ataatgaggt caggtgtgtg gtggacttgg attttcttga cgatggcgtt     1380

gatgaccatg gccatggcaa ccaccatcca ccgggacagg gaaggataca tggttatgcg     1440

ggccagtgga agggacgctg caagccaggt cagggtacaa aacggaacgt gcgtcatcct     1500

ggcaacagac atgggagagt ggtgtgaaga ttcaatcacc tactcttgcg tcacgattga     1560

ccaggaggaa gaacccgttg acgtggactg cttctgccga ggtgttgata gggttaagtt     1620

agagtatgga cgctgtggaa ggcaagctgg atctaggggg aaaaggtctg tggtcattcc     1680

aacacatgca caaaaagaca tggtcgggcg aggtcatgca tggcttaaag gtgacaatat     1740

tcgagatcat gtcacccgag tcgagggctg gatgtggaag aacaagcttc taactgccgc     1800

cattgtggcc ttggcttggc tcatggttga tagttggatg gccagagtga ctgtcatcct     1860

cttggcgttg agtctagggc cagtgtacgc cacgaggtgc acgcatcttg agaacagaga     1920

ttttgtgaca ggaactcaag ggaccaccag agtgtcacta gttttggaac ttggaggctg     1980

cgtgaccatc acagctgagg gcaagccatc cattgatgta tggctcgaag acatttttca     2040

ggaaagcccg gctgaaacca gagaatactg cctgcacgcc aaattgacca acacaaaagt     2100

ggaggctcgc tgtccaacca ctggaccggc gacacttccg gaggagcatc aggctaatat     2160

ggtgtgcaag agagaccaaa gcgaccgtgg atggggaaac cactgcgggt tttttgggaa     2220

gggcagtata gtggcttgtg caaagtttga atgcgaggaa gcaaaaaaag ctgtgggcca     2280

cgtctatgac tccacaaaga tcacgtatgt tgtcaaggtt gagccccaca caggggatta     2340

cttggctgca aatgagacca attcaaacag gaaatcagca cagtttacgg tggcatccga     2400

gaaagtgatc ctgcggctcg gcgactatgg agatgtgtcg ctgacgtgta aagtggcaag     2460

tgggattgat gtcgcccaaa ctgtggtgat gtcactcgac agcagcaagg accacctgcc     2520

ttctgcatgg caagtgcacc gtgactggtt tgaggacttg gcgctgccct ggaaacacaa     2580

ggacaaccaa gattggaaca gtgtggagaa acttgtggaa tttggaccac cacatgctgt     2640

gaaaatggat gttttcaatc tgggggacca gacggctgtg ctgctcaaat cactggcagg     2700

agttccgctg gccagtgtgg agggccagaa ataccacctg aaaagcggcc atgttacttg     2760

tgatgtggga ctggaaaagc tgaaactgaa aggcacaacc tactccatgt gtgacaaagc     2820

aaagttcaaa tggaagagag ttcctgtgga cagcggccat gacacagtag tcatggaggt     2880

atcatacaca ggaagcgaca agccatgtcg gatcccggtg cgggctgtgg cacatggtgt     2940

cccagcggtt aatgtagcca tgctcataac ccccaatcca accattgaaa caaatggtgg     3000

cggattcata gaaatgcagc tgccaccagg ggataacatc atctatgtgg gagaccttag     3060

ccagcagtgg tttcagaaag gcagtaccat tggtagaatg tttgaaaaaa cccgcagggg     3120

attggaaagg ctctctgtgg ttggagaaca tgcatgggac tttggctcag taggcggggt     3180

actgtcttct gtggggaagg caatccacac ggtgctgggg ggagctttca acaccctttt     3240

tgggggggtt ggattcatcc ctaagatgct gctgggggtt gctctggtct ggttgggact     3300

aaatgccagg aatccaacga tgtccatgac gtttcttgct gtgggggctt tgacactgat     3360

gatgacaatg ggagttgggg cataaaattg gatcagcttt tttttttttt tttttggcat     3420

ataaataagg tcgaagcttg gtaccaaaaa ttgaaaaact attctaattt attgcacatg     3480

gcctcctccg aggacgtcat caaagagttc atgcgcttca aggtgcgcat ggagggctcc     3540

gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc     3600

cagaccgcca agctgaaggt gaccaagggc ggccccctgc ccttcgcctg ggacatcctg     3660

tccccccagt tccagtacgg ctccaaggtg tacgtgaagc accccgccga catccccgac     3720

tacaagaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac     3780

ggcggcgtgg tgaccgtgac ccaggactcc tccctccagg acggctcctt catctacaag     3840

gtgaagttca tcggcgtgaa cttcccctcc gacggccccg taatgcagaa gaagactatg     3900

ggctgggagg cctccaccga gcgcctgtac ccccgcgacg gcgtgctgaa gggcgagatc     3960

cacaaggccc tgaagctgaa ggacggcggc cactacctgg tggagttcaa gtccatctac     4020

atggccaaga agcccgtgca gctgcccggc tactactacg tggactccaa gctggacatc     4080

acctcccaca acgaggacta caccatcgtg gagcagtacg agcgcgccga gggccgccac     4140

cacctgttcc tgtaggcatg catatatgct catatattta tagaagatat cacatatcta     4200

aatatcccta tcagtgatag agacggccga tgaataccgg aatcatagat ttatttgata     4260

atcatgttga tagtatacca actatattac ctcatcagtt agctactcta gattatctag     4320

ttagaactat catagatgag aacagaagcg tgttattgtt ccatattatg ggatcaggta     4380

aaacaataat cgctttgttg ttcgccttgg tagcttccag atttaaaaag gtttacattc     4440

tagtgcctaa tatcaacatt ttgaaaattt ttaattataa tatgggtgta gctatgaact     4500

tgtttaatga cgaattcata gctgagaata tctttattca ttccacaaca agtttttatt     4560

ctcttaatta taacgataac gtcattaatt ataacggatt atctcgctac aataactcta     4620

tttttatcgt tgatgaggca cataatatct ttgggaataa tactggagaa cttatgaccg     4680

tgataaaaaa taaaaacaag attccttttc tactattgtc tggatctccc attactaaca     4740

cacctaatac tctgggtcat attatagatt taatgtccga agagacgata gattttggtg     4800

agattattag tcgtggtaag aaagtaatt                                       4829


<210>  39
<211>  4829
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-POWV D6K SP)

<400>  39
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttaagac ccactttcac atttaagttg tttttctaat ccgcatatga      660

tcaattcaag gccgaataag aaggctggct ctgcaccttg gtgatcaaat aattcgatag      720

cttgtcgtaa taatggcggc atactatcag tagtaggtgt ttccctttct tctttagcga      780

cttgatgctc ttgatcttcc aatacgcaac ctaaagtaaa atgccccaca gcgctgagtg      840

catataatgc attctctagt gaaaaacctt gttggcaaag aaaggctaat tgattttcga      900

gagtttcata ctgtttttct gtaggccgtg tacctaaatg tacttttgct ccatcgcgat      960

gacttagtaa agcacatcta aaacttttag cgttattacg taaaaaatct tgccagcttt     1020

ccccttctaa agggcaaaag tgagtatggt gcctatctaa catctcaatg gctaaggcgt     1080

cgagcaaagc ccgcttattt tttacatgcc aatacaatgt aggctgctct acacctagct     1140

tctgggcgag tttacgggtt gttaaacctt cgattccgac ctcattaagc agctctaatg     1200

cgctgttaat cactttactt ttatctaatc tagacatgct agctatttat attccaaaaa     1260

aaaaaaataa aatttcaatt tttaactgca gttaaaaatt gaaattttat tttttttttt     1320

tggaatataa ataatgagat caggcgtcaa gtggacatgg actttcttgg taatggcttt     1380

gatggctatg gccatggcga cctccatcca tcgggataaa gagggatata tggtcatgcg     1440

agctagcgga agagatgccg caagccaagt cagagttcaa aacggaacat gcgtcatttt     1500

ggcaacggac atgggagaat ggtgtgaaga ttcaataacc tactcctgtg ttaccattga     1560

ccaggaagaa gaacctgttg atgtggattg tttttgccga ggtgttgaca gagtcaagtt     1620

agagtacgga cgctgtggaa gacaggctgg attcaggggg agaaggtctg tggtcatccc     1680

gacacatgca caaaaggaca tggttgggcg aggacacgcg tggctcaagg gtgataacat     1740

ccgagatcat gttacccgcg tcgagggctg gatgtggaaa aacaagctct tgacagttgc     1800

tgtcgtggct ttggcttggc tcatgctgga tagttggatg gctagggtga ctgtgatcct     1860

tctggcgctg agccttgggc ctgtatacgc cacgagatgc acacaccttg agaacaggga     1920

ctttgtgaca ggagtacagg gaaccactag agtatccctg gttctggagc ttggaggatg     1980

tgtgaccatt actgctgaag gcaagccatc aattgatgta tggctggagg acatttttca     2040

agaaagtcct gctgaaacca gagaatactg tttacacgcc aagctctcca acacgaaagt     2100

agaggctcgt tgccccacca ccgggccagc tacgcttcca gaggaacacc aggccaacat     2160

ggtgtgcaag agagaccaga gtgaccgtgg atggggaaac cactgcggat tttttgggaa     2220

aggaagcata gtggcctgtg ccaagtttga atgcgaggaa gcaaaaaagg cagtaggtca     2280

tgtttatgac tcaacaaaaa tcacgtacgt tgtcaaggtt gagccccaca cgggggacta     2340

ccaagctgca aatgaaacca acgagaacag gaaaacggcc cagttcacgg tggcatctga     2400

gaaggtgatc ttaaatctag gagactatgg agatgtatca ttgacatgta aggtggcaag     2460

tggaattgat gtcgcccaga ctgtggtgat gtcgcttggc agcagcaaag atcacctgcc     2520

ttcggcatgg caggtgcatc gtgactggtt cgaagaccta gccctgcctt ggaaacacaa     2580

agacaatcag gactggaaca gtgtggagaa acttgtggag tttgggccgc ctcatgcagt     2640

gaaaatggat atcttcaatc tgggggatca gactgctgtt ttgctcaaat cactggctgg     2700

agtcccactg gcaagcgtgg acaaccagaa atatcacctg aaaagtggtc atgtcacctg     2760

tgatgtggga cttgaaaagc tgaagctgaa aggcacaact tactccatgt gtgacaaaac     2820

aaagttcaag tggaaaagag ttcctgtgga cagtggccat gacacagtgg tcatggaggt     2880

gtcttacacg ggaagcgaca agccctgccg gattccggta cgagcagtgg cacatggtgt     2940

cccgacaatt aatgtggcca tgctcattac ccccaaccca actattgaaa caagtggagg     3000

aggatttata gagatgcagt tgccaccggg ggacaacatt atttatgtgg gggacctaag     3060

tcagcagtgg ttccagaaag gcagtaccat aggtagaatg ttcgaaaaga cccgtaaggg     3120

tttggaaaga ttttcagtgg ttggagaaca tgcatgggac tttggttcag tgggcggaat     3180

cctgtcgtca gtggggaaag ccgttcacac agtgttggga ggggcgttca acaccctttt     3240

tgggggagtt gggttcatcc ctaagatgct gttgggagtc gccttggtgt ggttggggct     3300

caacgctagg aatccaacaa tgtccatgac ttttcttgcc gtgggggttt tgaccctgat     3360

gatgacaatg ggagtcggag cataaaattg gatcagcttt tttttttttt tttttggcat     3420

ataaataagg tcgaagcttg gtaccaaaaa ttgaaaaact attctaattt attgcacatg     3480

gcctcctccg aggacgtcat caaagagttc atgcgcttca aggtgcgcat ggagggctcc     3540

gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc     3600

cagaccgcca agctgaaggt gaccaagggc ggccccctgc ccttcgcctg ggacatcctg     3660

tccccccagt tccagtacgg ctccaaggtg tacgtgaagc accccgccga catccccgac     3720

tacaagaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac     3780

ggcggcgtgg tgaccgtgac ccaggactcc tccctccagg acggctcctt catctacaag     3840

gtgaagttca tcggcgtgaa cttcccctcc gacggccccg taatgcagaa gaagactatg     3900

ggctgggagg cctccaccga gcgcctgtac ccccgcgacg gcgtgctgaa gggcgagatc     3960

cacaaggccc tgaagctgaa ggacggcggc cactacctgg tggagttcaa gtccatctac     4020

atggccaaga agcccgtgca gctgcccggc tactactacg tggactccaa gctggacatc     4080

acctcccaca acgaggacta caccatcgtg gagcagtacg agcgcgccga gggccgccac     4140

cacctgttcc tgtaggcatg catatatgct catatattta tagaagatat cacatatcta     4200

aatatcccta tcagtgatag agacggccga tgaataccgg aatcatagat ttatttgata     4260

atcatgttga tagtatacca actatattac ctcatcagtt agctactcta gattatctag     4320

ttagaactat catagatgag aacagaagcg tgttattgtt ccatattatg ggatcaggta     4380

aaacaataat cgctttgttg ttcgccttgg tagcttccag atttaaaaag gtttacattc     4440

tagtgcctaa tatcaacatt ttgaaaattt ttaattataa tatgggtgta gctatgaact     4500

tgtttaatga cgaattcata gctgagaata tctttattca ttccacaaca agtttttatt     4560

ctcttaatta taacgataac gtcattaatt ataacggatt atctcgctac aataactcta     4620

tttttatcgt tgatgaggca cataatatct ttgggaataa tactggagaa cttatgaccg     4680

tgataaaaaa taaaaacaag attccttttc tactattgtc tggatctccc attactaaca     4740

cacctaatac tctgggtcat attatagatt taatgtccga agagacgata gattttggtg     4800

agattattag tcgtggtaag aaagtaatt                                       4829


<210>  40
<211>  4829
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct (vIND-POWV JEV SP)

<400>  40
tgtttctcca ataaaattaa taatagaaac catgcgacaa tcattatcga tactaattac       60

aaacctgttt ttgataggat agataacgca ttaatgagaa gaattgccgt cgtgcgattc      120

agaacacact tttctcaacc ttctggtaga gaggctgctg aaaataatga cgcgtacgat      180

aaagtcaaac tattagacga ggggttagat ggtaaaatac aaaataatag atatagattc      240

gcatttctat acttgttggt gaaatggtac agaaaatatc atgttcctat tatgaaacta      300

tatcctacac ccgaagagat tcctgacttt gcattctatc tcaaaatagg tactctgtta      360

gtatctagct ctgtaaagca tattccatta atgacggacc tctccaaaaa gggatatata      420

ttgtacgata atgtggtcac tcttccgttg actactttcc aacagaaaat atccaagtat      480

tttaattcta gactatttgg acacgatata gagagcttca tcaatagaca taagaaattt      540

gccaatgtta gtgatgaata tctgcaatat atattcatag aggatatttc atctccgtaa      600

agaaaaaccc gggttaagac ccactttcac atttaagttg tttttctaat ccgcatatga      660

tcaattcaag gccgaataag aaggctggct ctgcaccttg gtgatcaaat aattcgatag      720

cttgtcgtaa taatggcggc atactatcag tagtaggtgt ttccctttct tctttagcga      780

cttgatgctc ttgatcttcc aatacgcaac ctaaagtaaa atgccccaca gcgctgagtg      840

catataatgc attctctagt gaaaaacctt gttggcaaag aaaggctaat tgattttcga      900

gagtttcata ctgtttttct gtaggccgtg tacctaaatg tacttttgct ccatcgcgat      960

gacttagtaa agcacatcta aaacttttag cgttattacg taaaaaatct tgccagcttt     1020

ccccttctaa agggcaaaag tgagtatggt gcctatctaa catctcaatg gctaaggcgt     1080

cgagcaaagc ccgcttattt tttacatgcc aatacaatgt aggctgctct acacctagct     1140

tctgggcgag tttacgggtt gttaaacctt cgattccgac ctcattaagc agctctaatg     1200

cgctgttaat cactttactt ttatctaatc tagacatgct agctatttat attccaaaaa     1260

aaaaaaataa aatttcaatt tttaactgca gttaaaaatt gaaattttat tttttttttt     1320

tggaatataa ataatgggag gaaatgaagg ctcaatcatg tggctcgcga gcttggcagt     1380

tgtcatagct tgtgcaggag ccaccatcca ccgggacagg gaaggataca tggttatgcg     1440

ggccagtgga agggacgctg caagccaggt cagggtacaa aacggaacgt gcgtcatcct     1500

ggcaacagac atgggagagt ggtgtgaaga ttcaatcacc tactcttgcg tcacgattga     1560

ccaggaggaa gaacccgttg acgtggactg cttctgccga ggtgttgata gggttaagtt     1620

agagtatgga cgctgtggaa ggcaagctgg atctaggggg aaaaggtctg tggtcattcc     1680

aacacatgca caaaaagaca tggtcgggcg aggtcatgca tggcttaaag gtgacaatat     1740

tcgagatcat gtcacccgag tcgagggctg gatgtggaag aacaagcttc taactgccgc     1800

cattgtggcc ttggcttggc tcatggttga tagttggatg gccagagtga ctgtcatcct     1860

cttggcgttg agtctagggc cagtgtacgc cacgaggtgc acgcatcttg agaacagaga     1920

ttttgtgaca ggaactcaag ggaccaccag agtgtcacta gttttggaac ttggaggctg     1980

cgtgaccatc acagctgagg gcaagccatc cattgatgta tggctcgaag acatttttca     2040

ggaaagcccg gctgaaacca gagaatactg cctgcacgcc aaattgacca acacaaaagt     2100

ggaggctcgc tgtccaacca ctggaccggc gacacttccg gaggagcatc aggctaatat     2160

ggtgtgcaag agagaccaaa gcgaccgtgg atggggaaac cactgcgggt tttttgggaa     2220

gggcagtata gtggcttgtg caaagtttga atgcgaggaa gcaaaaaaag ctgtgggcca     2280

cgtctatgac tccacaaaga tcacgtatgt tgtcaaggtt gagccccaca caggggatta     2340

cttggctgca aatgagacca attcaaacag gaaatcagca cagtttacgg tggcatccga     2400

gaaagtgatc ctgcggctcg gcgactatgg agatgtgtcg ctgacgtgta aagtggcaag     2460

tgggattgat gtcgcccaaa ctgtggtgat gtcactcgac agcagcaagg accacctgcc     2520

ttctgcatgg caagtgcacc gtgactggtt tgaggacttg gcgctgccct ggaaacacaa     2580

ggacaaccaa gattggaaca gtgtggagaa acttgtggaa tttggaccac cacatgctgt     2640

gaaaatggat gttttcaatc tgggggacca gacggctgtg ctgctcaaat cactggcagg     2700

agttccgctg gccagtgtgg agggccagaa ataccacctg aaaagcggcc atgttacttg     2760

tgatgtggga ctggaaaagc tgaaactgaa aggcacaacc tactccatgt gtgacaaagc     2820

aaagttcaaa tggaagagag ttcctgtgga cagcggccat gacacagtag tcatggaggt     2880

atcatacaca ggaagcgaca agccatgtcg gatcccggtg cgggctgtgg cacatggtgt     2940

cccagcggtt aatgtagcca tgctcataac ccccaatcca accattgaaa caaatggtgg     3000

cggattcata gaaatgcagc tgccaccagg ggataacatc atctatgtgg gagaccttag     3060

ccagcagtgg tttcagaaag gcagtaccat tggtagaatg tttgaaaaaa cccgcagggg     3120

attggaaagg ctctctgtgg ttggagaaca tgcatgggac tttggctcag taggcggggt     3180

actgtcttct gtggggaagg caatccacac ggtgctgggg ggagctttca acaccctttt     3240

tgggggggtt ggattcatcc ctaagatgct gctgggggtt gctctggtct ggttgggact     3300

aaatgccagg aatccaacga tgtccatgac gtttcttgct gtgggggctt tgacactgat     3360

gatgacaatg ggagttgggg cataaaattg gatcagcttt tttttttttt tttttggcat     3420

ataaataagg tcgaagcttg gtaccaaaaa ttgaaaaact attctaattt attgcacatg     3480

gcctcctccg aggacgtcat caaagagttc atgcgcttca aggtgcgcat ggagggctcc     3540

gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc     3600

cagaccgcca agctgaaggt gaccaagggc ggccccctgc ccttcgcctg ggacatcctg     3660

tccccccagt tccagtacgg ctccaaggtg tacgtgaagc accccgccga catccccgac     3720

tacaagaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac     3780

ggcggcgtgg tgaccgtgac ccaggactcc tccctccagg acggctcctt catctacaag     3840

gtgaagttca tcggcgtgaa cttcccctcc gacggccccg taatgcagaa gaagactatg     3900

ggctgggagg cctccaccga gcgcctgtac ccccgcgacg gcgtgctgaa gggcgagatc     3960

cacaaggccc tgaagctgaa ggacggcggc cactacctgg tggagttcaa gtccatctac     4020

atggccaaga agcccgtgca gctgcccggc tactactacg tggactccaa gctggacatc     4080

acctcccaca acgaggacta caccatcgtg gagcagtacg agcgcgccga gggccgccac     4140

cacctgttcc tgtaggcatg catatatgct catatattta tagaagatat cacatatcta     4200

aatatcccta tcagtgatag agacggccga tgaataccgg aatcatagat ttatttgata     4260

atcatgttga tagtatacca actatattac ctcatcagtt agctactcta gattatctag     4320

ttagaactat catagatgag aacagaagcg tgttattgtt ccatattatg ggatcaggta     4380

aaacaataat cgctttgttg ttcgccttgg tagcttccag atttaaaaag gtttacattc     4440

tagtgcctaa tatcaacatt ttgaaaattt ttaattataa tatgggtgta gctatgaact     4500

tgtttaatga cgaattcata gctgagaata tctttattca ttccacaaca agtttttatt     4560

ctcttaatta taacgataac gtcattaatt ataacggatt atctcgctac aataactcta     4620

tttttatcgt tgatgaggca cataatatct ttgggaataa tactggagaa cttatgaccg     4680

tgataaaaaa taaaaacaag attccttttc tactattgtc tggatctccc attactaaca     4740

cacctaatac tctgggtcat attatagatt taatgtccga agagacgata gattttggtg     4800

agattattag tcgtggtaag aaagtaatt                                       4829


