                               SEQUENCE LISTING

<110> MADDON ADVISORS LLC
 
<120> ANTI-CCR5 MONOCLONAL ANTIBODY-BASED COMPOSITIONS AND METHODS

<130> MADDON-8PCT

<140> PCT/US2021/038349
<141> 2021-06-22

<150> 63/062,506
<151> 2020-08-07

<150> 63/042,661
<151> 2020-06-23

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (12)..(12)
<223> 6H,8H-3,4-dihydropyrimido[4,5-c] [1,2]oxazin-7-one

<400> 1
gtctgcgtca tntggtgcat tc                                                22


<210> 2
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (7)..(7)
<223> 2-amino-6-methoxyaminopurine

<220>
<221> modified_base
<222> (22)..(22)
<223> 6H,8H-3,4-dihydropyrimido[4,5-c] [1,2]oxazin-7-one

<400> 2
cactagntgt ctctgcacta tntgttttg                                         29


<210> 3
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe


<220>
<221> modified_base
<222> (5)..(5)
<223> 6H,8H-3,4-dihydropyrimido[4,5-c] [1,2]oxazin-7-one

<220>
<221> modified_base
<222> (11)..(11)
<223> 2-amino-6-methoxyaminopurine

<400> 3
cttcntcagt ntgtttcact ttctcttctg cg                                     32


<210> 4
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
ggcatagcct cataaaatat ctg                                               23


<210> 5
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
acagagcgaa atgcagtgat att                                               23


<210> 6
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      furin cleavage sequence

<400> 6
Arg Lys Arg Arg 
1               


<210> 7
<211> 429
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (12)..(404)

<400> 7
tctagaccac c atg aag ttg cct gtt agg ctg ttg gtg ctg atg ttc tgg        50
             Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp          
             1               5                   10                       

att cct gct tcc agc agt gat att gtg atg acc caa tct cca ctc tcc         98
Ile Pro Ala Ser Ser Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser           
    15                  20                  25                            

ctg cct gtc act cct gga gag cca gcc tcc atc tct tgc aga tct agt        146
Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser           
30                  35                  40                  45            

cag cgc ctt ctg agc agt tat gga cat acc tat tta cat tgg tac cta        194
Gln Arg Leu Leu Ser Ser Tyr Gly His Thr Tyr Leu His Trp Tyr Leu           
                50                  55                  60                

cag aag cca ggc cag tct cca cag ctc ctg atc tac gaa gtt tcc aac        242
Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn           
            65                  70                  75                    

cga ttt tct ggg gtc cca gac agg ttc agt ggc agt ggg tca ggg aca        290
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr           
        80                  85                  90                        

gat ttc aca ctt aag atc agt aga gtg gag gct gag gat gtg gga gtt        338
Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val           
    95                  100                 105                           

tat tac tgc tct caa agt aca cat gtt cct ctc acg ttc gga cag ggg        386
Tyr Tyr Cys Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Gln Gly           
110                 115                 120                 125           

acc aag gtg gaa ata aaa cgtaagtagt cttctcaact ctaga                    429
Thr Lys Val Glu Ile Lys                                                   
                130                                                       


<210> 8
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu 
        35                  40                  45              


Leu Ser Ser Tyr Gly His Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys 
    130     


<210> 9
<211> 457
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (12)..(434)

<400> 9
acgcgtccac c atg gaa tgg agc gga gtc ttt atc ttt ctc ctg tca gta        50
             Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val          
             1               5                   10                       

act gca ggt gtc cac tcc gag gtg cag ctg gtg gag tct ggt gga ggc         98
Thr Ala Gly Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly           
    15                  20                  25                            

ttg gta aag cct gga ggt tcc ctt aga ctc tcc tgt gca gcc tct ggt        146
Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly           
30                  35                  40                  45            

tac act ttc agt aac tat tgg atc gga tgg gtc cgc cag gct cca ggc        194
Tyr Thr Phe Ser Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly           
                50                  55                  60                

aaa ggg ctg gag tgg att ggc gat atc tac cct gga ggg aac tac atc        242
Lys Gly Leu Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile           
            65                  70                  75                    

agg aac aat gag aag ttc aag gac aag acc acc ctg tca gca gat act        290
Arg Asn Asn Glu Lys Phe Lys Asp Lys Thr Thr Leu Ser Ala Asp Thr           
        80                  85                  90                        

tcc aag aac aca gcc tat ctg caa atg aac agc ctg aaa acc gag gac        338
Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp           
    95                  100                 105                           

aca gcc gtg tat tac tgt gga agc agc ttc ggt agt aac tac gtg ttc        386
Thr Ala Val Tyr Tyr Cys Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe           
110                 115                 120                 125           

gcc tgg ttt act tac tgg ggc caa ggg act ctg gtc aca gtc tcc tca        434
Ala Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser           
                130                 135                 140               

ggtgagtcct taaaacctct aga                                              457


<210> 10
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile Arg Asn Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asp Lys Thr Thr Leu Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe Ala Trp Phe 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140     


<210> 11
<211> 457
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (12)..(434)

<400> 11
tctagaccac c atg gaa tgg agc ggg gtc ttt atc ttt ctc ctg tca gta        50
             Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val          
             1               5                   10                       

act gca ggt gtc cac tcc cag gtc caa ctg gtg cag tct gga cct gat         98
Thr Ala Gly Val His Ser Gln Val Gln Leu Val Gln Ser Gly Pro Asp           
    15                  20                  25                            

gtg aaa aag cct ggg act tca atg aag atg tcc tgc aag acg tct gga        146
Val Lys Lys Pro Gly Thr Ser Met Lys Met Ser Cys Lys Thr Ser Gly           
30                  35                  40                  45            

tac acc ttc agt aac tat tgg atc gga tgg gtt agg cag gcg cct gga        194
Tyr Thr Phe Ser Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly           
                50                  55                  60                

caa ggc ctt gag tgg att gga gat att tac cct gga ggg aac tat atc        242
Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile           
            65                  70                  75                    

agg aac aat gag aag ttc aag gac aag acc aca ctg acg gca gac aca        290
Arg Asn Asn Glu Lys Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Thr           
        80                  85                  90                        

tcg acc agc acg gcc tac atg caa ctt ggc agc ctg aga tct gaa gac        338
Ser Thr Ser Thr Ala Tyr Met Gln Leu Gly Ser Leu Arg Ser Glu Asp           
    95                  100                 105                           

act gcc gtc tat tac tgt gga agc agc ttc ggt agt aac tac gtg ttc        386
Thr Ala Val Tyr Tyr Cys Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe           
110                 115                 120                 125           

gcc tgg ttt act tac tgg ggc caa ggg act ctg gtc aca gtc tcc tca        434
Ala Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser           
                130                 135                 140               

ggtgagtcct taaaacctct aga                                              457


<210> 12
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Pro Asp Val Lys Lys 
            20                  25                  30          


Pro Gly Thr Ser Met Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile Arg Asn Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Gly Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe Ala Trp Phe 
        115                 120                 125             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140     


