                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Fischer, Eric 
       Nowak, Radoslaw
       Xiong, Yuan
 
<120>  PROTEIN TAG TO INDUCE LIGAND DEPENDENT DEGRADATION OF 
       PROTEIN/PROTEIN-FUSIONS

<130>  52095-627001WO

<140>  NOT YET ASSIGNED
<141>  2021-06-21

<150>  US 63/042,257
<151>  2020-06-22

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  1362
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                 200                 205             


Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu 
705                 710                 715                 720 


Met Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys 
                725                 730                 735     


Lys His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro 
            740                 745                 750         


Val Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro 
        755                 760                 765             


Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    770                 775                 780                 


Met Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe 
785                 790                 795                 800 


Ile Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val 
                805                 810                 815     


Phe Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln 
            820                 825                 830         


Pro Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro 
        835                 840                 845             


Pro His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn 
    850                 855                 860                 


Ala Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu 
865                 870                 875                 880 


Pro Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln 
                885                 890                 895     


Thr Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu 
            900                 905                 910         


Leu Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met 
        915                 920                 925             


Gln Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu 
    930                 935                 940                 


Leu Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro 
945                 950                 955                 960 


Pro Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro 
                965                 970                 975     


Pro Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro 
            980                 985                 990         


Pro Pro Arg Pro Val His Leu Gln  Pro Met Gln Phe Ser  Thr His Ile 
        995                 1000                 1005             


Gln Gln  Pro Pro Pro Pro Gln  Gly Gln Gln Pro Pro  His Pro Pro 
    1010                 1015                 1020             


Pro Gly  Gln Gln Pro Pro Pro  Pro Gln Pro Ala Lys  Pro Gln Gln 
    1025                 1030                 1035             


Val Ile  Gln His His His Ser  Pro Arg His His Lys  Ser Asp Pro 
    1040                 1045                 1050             


Tyr Ser  Thr Gly His Leu Arg  Glu Ala Pro Ser Pro  Leu Met Ile 
    1055                 1060                 1065             


His Ser  Pro Gln Met Ser Gln  Phe Gln Ser Leu Thr  His Gln Ser 
    1070                 1075                 1080             


Pro Pro  Gln Gln Asn Val Gln  Pro Lys Lys Gln Glu  Leu Arg Ala 
    1085                 1090                 1095             


Ala Ser  Val Val Gln Pro Gln  Pro Leu Val Val Val  Lys Glu Glu 
    1100                 1105                 1110             


Lys Ile  His Ser Pro Ile Ile  Arg Ser Glu Pro Phe  Ser Pro Ser 
    1115                 1120                 1125             


Leu Arg  Pro Glu Pro Pro Lys  His Pro Glu Ser Ile  Lys Ala Pro 
    1130                 1135                 1140             


Val His  Leu Pro Gln Arg Pro  Glu Met Lys Pro Val  Asp Val Gly 
    1145                 1150                 1155             


Arg Pro  Val Ile Arg Pro Pro  Glu Gln Asn Ala Pro  Pro Pro Gly 
    1160                 1165                 1170             


Ala Pro  Asp Lys Asp Lys Gln  Lys Gln Glu Pro Lys  Thr Pro Val 
    1175                 1180                 1185             


Ala Pro  Lys Lys Asp Leu Lys  Ile Lys Asn Met Gly  Ser Trp Ala 
    1190                 1195                 1200             


Ser Leu  Val Gln Lys His Pro  Thr Thr Pro Ser Ser  Thr Ala Lys 
    1205                 1210                 1215             


Ser Ser  Ser Asp Ser Phe Glu  Gln Phe Arg Arg Ala  Ala Arg Glu 
    1220                 1225                 1230             


Lys Glu  Glu Arg Glu Lys Ala  Leu Lys Ala Gln Ala  Glu His Ala 
    1235                 1240                 1245             


Glu Lys  Glu Lys Glu Arg Leu  Arg Gln Glu Arg Met  Arg Ser Arg 
    1250                 1255                 1260             


Glu Asp  Glu Asp Ala Leu Glu  Gln Ala Arg Arg Ala  His Glu Glu 
    1265                 1270                 1275             


Ala Arg  Arg Arg Gln Glu Gln  Gln Gln Gln Gln Arg  Gln Glu Gln 
    1280                 1285                 1290             


Gln Gln  Gln Gln Gln Gln Gln  Ala Ala Ala Val Ala  Ala Ala Ala 
    1295                 1300                 1305             


Thr Pro  Gln Ala Gln Ser Ser  Gln Pro Gln Ser Met  Leu Asp Gln 
    1310                 1315                 1320             


Gln Arg  Glu Leu Ala Arg Lys  Arg Glu Gln Glu Arg  Arg Arg Arg 
    1325                 1330                 1335             


Glu Ala  Met Ala Ala Thr Ile  Asp Met Asn Phe Gln  Ser Asp Leu 
    1340                 1345                 1350             


Leu Ser  Ile Phe Glu Glu Asn  Leu Phe 
    1355                 1360         


<210>  2
<211>  5198
<212>  DNA
<213>  Homo sapiens

<400>  2
attctttgga atactactgc tagaagtctg acttaagacc cagcttatgg gccacatggc       60

acccagctgc ttctgcagag aaggcaggcc actgatgggt acagcaaagt gtggtgctgc      120

tggccaagcc aaagacccgt gtaggatgac tgggcctctg ccccttgtgg gtgttgccac      180

tgtgcttgag tgcctggtga agaatgtgat gggatcacta gcatgtctgc ggagagcggc      240

cctgggacga gattgagaaa tctgccagta atgggggatg gactagaaac ttcccaaatg      300

tctacaacac aggcccaggc ccaaccccag ccagccaacg cagccagcac caaccccccg      360

cccccagaga cctccaaccc taacaagccc aagaggcaga ccaaccaact gcaatacctg      420

ctcagagtgg tgctcaagac actatggaaa caccagtttg catggccttt ccagcagcct      480

gtggatgccg tcaagctgaa cctccctgat tactataaga tcattaaaac gcctatggat      540

atgggaacaa taaagaagcg cttggaaaac aactattact ggaatgctca ggaatgtatc      600

caggacttca acactatgtt tacaaattgt tacatctaca acaagcctgg agatgacata      660

gtcttaatgg cagaagctct ggaaaagctc ttcttgcaaa aaataaatga gctacccaca      720

gaagaaaccg agatcatgat agtccaggca aaaggaagag gacgtgggag gaaagaaaca      780

gggacagcaa aacctggcgt ttccacggta ccaaacacaa ctcaagcatc gactcctccg      840

cagacccaga cccctcagcc gaatcctcct cctgtgcagg ccacgcctca ccccttccct      900

gccgtcaccc cggacctcat cgtccagacc cctgtcatga cagtggtgcc tccccagcca      960

ctgcagacgc ccccgccagt gcccccccag ccacaacccc cacccgctcc agctccccag     1020

cccgtacaga gccacccacc catcatcgcg gccaccccac agcctgtgaa gacaaagaag     1080

ggagtgaaga ggaaagcaga caccaccacc cccaccacca ttgaccccat tcacgagcca     1140

ccctcgctgc ccccggagcc caagaccacc aagctgggcc agcggcggga gagcagccgg     1200

cctgtgaaac ctccaaagaa ggacgtgccc gactctcagc agcacccagc accagagaag     1260

agcagcaagg tctcggagca gctcaagtgc tgcagcggca tcctcaagga gatgtttgcc     1320

aagaagcacg ccgcctacgc ctggcccttc tacaagcctg tggacgtgga ggcactgggc     1380

ctacacgact actgtgacat catcaagcac cccatggaca tgagcacaat caagtctaaa     1440

ctggaggccc gtgagtaccg tgatgctcag gagtttggtg ctgacgtccg attgatgttc     1500

tccaactgct ataagtacaa ccctcctgac catgaggtgg tggccatggc ccgcaagctc     1560

caggatgtgt tcgaaatgcg ctttgccaag atgccggacg agcctgagga gccagtggtg     1620

gccgtgtcct ccccggcagt gccccctccc accaaggttg tggccccgcc ctcatccagc     1680

gacagcagca gcgatagctc ctcggacagt gacagttcga ctgatgactc tgaggaggag     1740

cgagcccagc ggctggctga gctccaggag cagctcaaag ccgtgcacga gcagcttgca     1800

gccctctctc agccccagca gaacaaacca aagaaaaagg agaaagacaa gaaggaaaag     1860

aaaaaagaaa agcacaaaag gaaagaggaa gtggaagaga ataaaaaaag caaagccaag     1920

gaacctcctc ctaaaaagac gaagaaaaat aatagcagca acagcaatgt gagcaagaag     1980

gagccagcgc ccatgaagag caagccccct cccacgtatg agtcggagga agaggacaag     2040

tgcaagccta tgtcctatga ggagaagcgg cagctcagct tggacatcaa caagctcccc     2100

ggcgagaagc tgggccgcgt ggtgcacatc atccagtcac gggagccctc cctgaagaat     2160

tccaaccccg acgagattga aatcgacttt gagaccctga agccgtccac actgcgtgag     2220

ctggagcgct atgtcacctc ctgtttgcgg aagaaaagga aacctcaagc tgagaaagtt     2280

gatgtgattg ccggctcctc caagatgaag ggcttctcgt cctcagagtc ggagagctcc     2340

agtgagtcca gctcctctga cagcgaagac tccgaaacag agatggctcc gaagtcaaaa     2400

aagaaggggc accccgggag ggagcagaag aagcaccatc atcaccacca tcagcagatg     2460

cagcaggccc cggctcctgt gccccagcag ccgcccccgc ctccccagca gcccccaccg     2520

cctccacctc cgcagcagca acagcagccg ccacccccgc ctcccccacc ctccatgccg     2580

cagcaggcag ccccggcgat gaagtcctcg cccccaccct tcattgccac ccaggtgccc     2640

gtcctggagc cccagctccc aggcagcgtc tttgacccca tcggccactt cacccagccc     2700

atcctgcacc tgccgcagcc tgagctgccc cctcacctgc cccagccgcc tgagcacagc     2760

actccacccc atctcaacca gcacgcagtg gtctctcctc cagctttgca caacgcacta     2820

ccccagcagc catcacggcc cagcaaccga gccgctgccc tgcctcccaa gcccgcccgg     2880

cccccagccg tgtcaccagc cttgacccaa acacccctgc tcccacagcc ccccatggcc     2940

caaccccccc aagtgctgct ggaggatgaa gagccacctg ccccacccct cacctccatg     3000

cagatgcagc tgtacctgca gcagctgcag aaggtgcagc cccctacgcc gctactccct     3060

tccgtgaagg tgcagtccca gcccccaccc cccctgccgc ccccacccca cccctctgtg     3120

cagcagcagc tgcagcagca gccgccacca cccccaccac cccagcccca gcctccaccc     3180

cagcagcagc atcagccccc tccacggccc gtgcacttgc agcccatgca gttttccacc     3240

cacatccaac agcccccgcc accccagggc cagcagcccc cccatccgcc cccaggccag     3300

cagccacccc cgccgcagcc tgccaagcct cagcaagtca tccagcacca ccattcaccc     3360

cggcaccaca agtcggaccc ctactcaacc ggtcacctcc gcgaagcccc ctccccgctt     3420

atgatacatt ccccccagat gtcacagttc cagagcctga cccaccagtc tccaccccag     3480

caaaacgtcc agcctaagaa acaggagctg cgtgctgcct ccgtggtcca gccccagccc     3540

ctcgtggtgg tgaaggagga gaagatccac tcacccatca tccgcagcga gcccttcagc     3600

ccctcgctgc ggccggagcc ccccaagcac ccggagagca tcaaggcccc cgtccacctg     3660

ccccagcggc cggaaatgaa gcctgtggat gtcgggaggc ctgtgatccg gcccccagag     3720

cagaacgcac cgccaccagg ggcccctgac aaggacaaac agaaacagga gccgaagact     3780

ccagttgcgc ccaaaaagga cctgaaaatc aagaacatgg gctcctgggc cagcctagtg     3840

cagaagcatc cgaccacccc ctcctccaca gccaagtcat ccagcgacag cttcgagcag     3900

ttccgccgcg ccgctcggga gaaagaggag cgtgagaagg ccctgaaggc tcaggccgag     3960

cacgctgaga aggagaagga gcggctgcgg caggagcgca tgaggagccg agaggacgag     4020

gatgcgctgg agcaggcccg gcgggcccat gaggaggcac gtcggcgcca ggagcagcag     4080

cagcagcagc gccaggagca acagcagcag cagcaacagc aagcagctgc ggtggctgcc     4140

gccgccaccc cacaggccca gagctcccag ccccagtcca tgctggacca gcagagggag     4200

ttggcccgga agcgggagca ggagcgaaga cgccgggaag ccatggcagc taccattgac     4260

atgaatttcc agagtgatct attgtcaata tttgaagaaa atcttttctg agcgcaccta     4320

ggtggcttct gactttgatt ttctggcaaa acattgactt tccatagtgt taggggcggt     4380

ggtggaggtg ggatcagcgg ccaggggatg cctcagggcc tggccctcct gcatgctatg     4440

cccggggcag gcctgacggg cagctgagga ttgcagagcc tgtctgcctt acggccagtc     4500

ggacagacgt cccgccaccc accacccctc acaggacgtc cgctcagcac acgccttgtt     4560

acgagcaagt gccggctgga cccaagccct gcatccccac atgcggggca gaggcccttc     4620

tctccgccaa atgtctacac agtatacaca ggacatcgtt gctgccgccg tgactggttt     4680

tctgtcccca agaacgtgac gttcgtgatg tcctgcccgc cgggagtctt tccccacacc     4740

ccagccatcg ccgcccgctc ccaggaggcc agggcaggcc tgcgtgggct ggaggcgggc     4800

gaggccggcc caccccctcg ctggcactga ctttgccttg aacagacccc ccgaccctcc     4860

cccacaagcc tttaattgag agccgctctc tgtaagtgtt tgcttgtgca aaagggaata     4920

gtgccgtgga ggtgtgtgtg tccatggcat ccggagcgag gcgactgtcc tgcgtgggta     4980

gccctcggcc ggggagtgag gccaccaacc aaagtcagtt ccttcccacc tgtgtttctg     5040

tttcgttttt ttttttcttt tttttctata tatatttttt gttgaattct attttatttt     5100

taattctctc ttctcctcca gacacaatgg cactgcttat ctccgaaatg gtgtgatcgt     5160

ctcctcattg agcagcggct gccaccgcgc tgtgggta                             5198


<210>  3
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                  70                  75                  80  


Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp 
                85                  90                  95      


Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys 
            100                 105                 110         


Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala 
        115                 120                 125             


Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu 
    130                 135                 140                 


Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala 
145                 150                 155                 160 


Ala Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser 
                165                 170                 175     


Val Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln 
            180                 185                 190         


Thr Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val 
        195                 200                 205             


Thr Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr 
    210                 215                 220                 


Pro Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys 
225                 230                 235                 240 


Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile 
                245                 250                 255     


Thr Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln 
            260                 265                 270         


Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro 
        275                 280                 285             


Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys 
    290                 295                 300                 


Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg 
305                 310                 315                 320 


Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys 
                325                 330                 335     


Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile 
            340                 345                 350         


Lys His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg 
        355                 360                 365             


Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe 
    370                 375                 380                 


Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met 
385                 390                 395                 400 


Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
                405                 410                 415     


Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met 
            420                 425                 430         


Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser 
        435                 440                 445             


Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Thr Arg Leu Ala 
    450                 455                 460                 


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu 
                485                 490                 495     


Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys 
            500                 505                 510         


Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys 
        515                 520                 525             


Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Thr Thr 
    530                 535                 540                 


Thr Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser 
545                 550                 555                 560 


Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu 
                565                 570                 575     


Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu 
            580                 585                 590         


Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp 
        595                 600                 605             


Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Thr 
    610                 615                 620                 


Thr Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys 
625                 630                 635                 640 


Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser 
                645                 650                 655     


Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu 
            660                 665                 670         


Gln Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys 
        675                 680                 685             


Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser 
    690                 695                 700                 


Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser 
705                 710                 715                 720 


Asp Ser Ser Asp Ser Glu 
                725     


<210>  4
<211>  3242
<212>  DNA
<213>  Homo sapiens

<400>  4
aggctaatta ggcgcgcggt ttgtttacaa acacgggctc ccggcaggtg cgcgccgccc       60

cgcccgtgcg cggccggggt tcgagggtgg ctcccgcggg cctcggggtg cccggacggg      120

ggctgcggtg ctggctgcgt gcccgcttct tccatgccgt cctggggcac cggaaaatcc      180

gccgccaggc gctgtccccg acacgggctg tcgcctggtt gggcccggaa atgggacgtc      240

gcgctttctc agggagcgta gaagcagcca gggcctctcc aagccgctgc tgtgacagaa      300

agtgagtgag ctgccggagg atgtccaccg ccacgacagt cgcccccgcg gggatcccgg      360

cgaccccggg ccctgtgaac ccaccccccc cggaggtctc caaccccagc aagcccggcc      420

gcaagaccaa ccagctgcag tacatgcaga atgtggtggt gaagacgctc tggaaacacc      480

agttcgcctg gcccttctac cagcccgtgg acgcaatcaa attgaacctg ccggattatc      540

ataaaataat taaaaaccca atggatatgg ggactattaa gaagagacta gaaaataatt      600

attattggag tgcaagcgaa tgtatgcagg acttcaacac catgtttaca aattgttaca      660

tttataacaa gcccacagat gacatagtgc taatggccca agctttagag aaaatttttc      720

tacaaaaagt ggcccagatg ccccaagagg aagttgaatt attaccccct gctccaaagg      780

gcaaaggtcg gaagccggct gcgggagccc agagcgcagg tacacagcaa gtggcggccg      840

tgtcctctgt ctccccagcg accccctttc agagcgtgcc ccccaccgtc tcccagacgc      900

ccgtcatcgc tgccacccct gtaccaacca tcactgcaaa cgtcacgtcg gtcccagtcc      960

ccccagctgc cgccccacct cctcctgcca cacccatcgt ccccgtggtc cctcctacgc     1020

cgcctgtcgt caagaaaaag ggcgtgaagc ggaaagcaga cacaaccact cccacgacgt     1080

cggccatcac tgccagccgg agtgagtcgc ccccgccgtt gtcagacccc aagcaggcca     1140

aagtggtggc ccggcgggag agtggtggcc gccccatcaa gcctcccaag aaggacctgg     1200

aggacggcga ggtgccccag cacgcaggca agaagggcaa gctgtcggag cacctacgct     1260

actgcgacag catcctcagg gagatgctat ccaagaagca cgcggcctac gcctggccct     1320

tctacaagcc agtggatgcc gaggccctgg agctgcacga ctaccacgac atcatcaagc     1380

acccgatgga cctcagcacc gtgaaaagga agatggatgg ccgagagtac ccagacgcac     1440

agggctttgc tgctgatgtc cggctgatgt tctcgaattg ctacaaatac aatcccccag     1500

accacgaggt tgtggccatg gcccggaagc tccaggacgt gtttgagatg aggtttgcca     1560

agatgccaga tgagcccgtg gaggcaccgg cgctgcctgc ccccgcggcc cccatggtga     1620

gcaagggcgc tgagagcagc cgtagcagtg aggagagctc ttcggactca ggcagctcgg     1680

actcggagga ggagcgggcc accaggctgg cggagctgca ggagcagctg aaggccgtgc     1740

acgagcagct ggccgccctg tctcaggccc cagtaaacaa accaaagaag aagaaggaga     1800

agaaggagaa ggagaagaag aagaaggaca aggagaagga gaaggagaag cacaaagtga     1860

aggccgagga agagaagaag gccaaggtgg ctccgcctgc caagcaggct cagcagaaga     1920

aggctcctgc caagaaggcc aacagcacga ccacggccgg cagacagctg aagaaaggcg     1980

gcaagcaggc atctgcctcc tacgactcag aggaagagga ggagggcctg cccatgagct     2040

acgatgaaaa gcgccagctt agcctggaca tcaaccggct gcccggggag aagctgggcc     2100

gggtagtgca catcatccaa tctcgggagc cctcgctcag ggactccaac cccgacgaga     2160

tagaaattga ctttgagact ctgaaaccca ccactttgcg ggaactggag agatatgtca     2220

agtcttgttt acagaaaaag caaaggaaac cgttctcagc aagcgggaag aaacaggcag     2280

ccaagtcgaa agaggagcta gctcaggaaa agaagaagga gctggaaaag cgtctgcagg     2340

atgtcagcgg gcagctgagc agcagcaaga agcccgcccg gaaagagaag cccggctcag     2400

caccctcagg gggcccgtcc aggctcagca gcagcagctc ctccgagtct gggagcagca     2460

gctccagcgg gtccagctct gacagcagtg actcagaatg aactggcttc ggacagaaca     2520

ggacagatgg atgtcgcaca cgccgagact ctgccgtacc cctctgtggt tcatattact     2580

acttctgttc catggtgtgc aggtctgctt cttaattcag tgttatgata tcttccagtt     2640

tttgctttca taggtcagag atctatcttg tgtgtgcgtt agacttgatg agaaggtgtg     2700

aactctgcag aaagtctctt cttcatcact gaattcagtc acttggagat gacaacttca     2760

aatgctaacc cgatgacccc agaaaaccgt gtgagattcg taccgaagaa ccttgtggaa     2820

tccctttgct taggcccaac ctggtcgata gctcgagaaa gaattttttc caaggaaatg     2880

tctcggatat gggtactgta tttgaaagct gttagctttg tcaacacgca ttgtccttgt     2940

catttgggcc ccgagctctg accctcgtgt ctgacgcggc cacctctttc tggaggggct     3000

gaggacagat gtgcctgctt gtggagacca ggctgggcct aagcgaaggg tcatcgcagc     3060

cccagcccgg agcgtggagc ccttgggggg tggtcgggtg ggatgtgcgt tctccgctcg     3120

tggtgatgtc aggagctcct cggagggaac agagcggctg tgtatgcagc ctgcaggttt     3180

ccatacactg aagcttttac ctcaacttta aaaaaaaaaa aagaagaaaa gatttaaaaa     3240

aa                                                                    3242


<210>  5
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Gln Asn Val Thr Pro His Asn Lys Leu Pro Gly Glu Gly Asn 
1               5                   10                  15      


Ala Gly Leu Leu Gly Leu Gly Pro Glu Ala Ala Ala Pro Gly Lys Arg 
            20                  25                  30          


Ile Arg Lys Pro Ser Leu Leu Tyr Glu Gly Phe Glu Ser Pro Thr Met 
        35                  40                  45              


Ala Ser Val Pro Ala Leu Gln Leu Thr Pro Ala Asn Pro Pro Pro Pro 
    50                  55                  60                  


Glu Val Ser Asn Pro Lys Lys Pro Gly Arg Val Thr Asn Gln Leu Gln 
65                  70                  75                  80  


Tyr Leu His Lys Val Val Met Lys Ala Leu Trp Lys His Gln Phe Ala 
                85                  90                  95      


Trp Pro Phe Arg Gln Pro Val Asp Ala Val Lys Leu Gly Leu Pro Asp 
            100                 105                 110         


Tyr His Lys Ile Ile Lys Gln Pro Met Asp Met Gly Thr Ile Lys Arg 
        115                 120                 125             


Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp 
    130                 135                 140                 


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp 
145                 150                 155                 160 


Asp Ile Val Leu Met Ala Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys 
                165                 170                 175     


Val Ala Ser Met Pro Gln Glu Glu Gln Glu Leu Val Val Thr Ile Pro 
            180                 185                 190         


Lys Asn Ser His Lys Lys Gly Ala Lys Leu Ala Ala Leu Gln Gly Ser 
        195                 200                 205             


Val Thr Ser Ala His Gln Val Pro Ala Val Ser Ser Val Ser His Thr 
    210                 215                 220                 


Ala Leu Tyr Thr Pro Pro Pro Glu Ile Pro Thr Thr Val Leu Asn Ile 
225                 230                 235                 240 


Pro His Pro Ser Val Ile Ser Ser Pro Leu Leu Lys Ser Leu His Ser 
                245                 250                 255     


Ala Gly Pro Pro Leu Leu Ala Val Thr Ala Ala Pro Pro Ala Gln Pro 
            260                 265                 270         


Leu Ala Lys Lys Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro 
        275                 280                 285             


Thr Pro Thr Ala Ile Leu Ala Pro Gly Ser Pro Ala Ser Pro Pro Gly 
    290                 295                 300                 


Ser Leu Glu Pro Lys Ala Ala Arg Leu Pro Pro Met Arg Arg Glu Ser 
305                 310                 315                 320 


Gly Arg Pro Ile Lys Pro Pro Arg Lys Asp Leu Pro Asp Ser Gln Gln 
                325                 330                 335     


Gln His Gln Ser Ser Lys Lys Gly Lys Leu Ser Glu Gln Leu Lys His 
            340                 345                 350         


Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys His Ala Ala Tyr 
        355                 360                 365             


Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala Leu Gly Leu His 
    370                 375                 380                 


Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu Ser Thr Val Lys 
385                 390                 395                 400 


Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln Glu Phe Ala Ala 
                405                 410                 415     


Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp 
            420                 425                 430         


His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Phe 
        435                 440                 445             


Arg Tyr Ala Lys Met Pro Asp Glu Pro Leu Glu Pro Gly Pro Leu Pro 
    450                 455                 460                 


Val Ser Thr Ala Met Pro Pro Gly Leu Ala Lys Ser Ser Ser Glu Ser 
465                 470                 475                 480 


Ser Ser Glu Glu Ser Ser Ser Glu Ser Ser Ser Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Ser Glu Ser Ser Asp Ser 
            500                 505                 510         


Glu Glu Glu Arg Ala His Arg Leu Ala Glu Leu Gln Glu Gln Leu Arg 
        515                 520                 525             


Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Gly Pro Ile Ser Lys 
    530                 535                 540                 


Pro Lys Arg Lys Arg Glu Lys Lys Glu Lys Lys Lys Lys Arg Lys Ala 
545                 550                 555                 560 


Glu Lys His Arg Gly Arg Ala Gly Ala Asp Glu Asp Asp Lys Gly Pro 
                565                 570                 575     


Arg Ala Pro Arg Pro Pro Gln Pro Lys Lys Ser Lys Lys Ala Ser Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Ala Ala Leu Gly Pro Ser Gly Phe Gly Pro Ser 
        595                 600                 605             


Gly Gly Ser Gly Thr Lys Leu Pro Lys Lys Ala Thr Lys Thr Ala Pro 
    610                 615                 620                 


Pro Ala Leu Pro Thr Gly Tyr Asp Ser Glu Glu Glu Glu Glu Ser Arg 
625                 630                 635                 640 


Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
                645                 650                 655     


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ala Arg 
            660                 665                 670         


Glu Pro Ser Leu Arg Asp Ser Asn Pro Glu Glu Ile Glu Ile Asp Phe 
        675                 680                 685             


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Leu 
    690                 695                 700                 


Ser Cys Leu Arg Lys Lys Pro Arg Lys Pro Tyr Thr Ile Lys Lys Pro 
705                 710                 715                 720 


Val Gly Lys Thr Lys Glu Glu Leu Ala Leu Glu Lys Lys Arg Glu Leu 
                725                 730                 735     


Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Asn Ser Thr Lys Lys 
            740                 745                 750         


Pro Pro Lys Lys Ala Asn Glu Lys Thr Glu Ser Ser Ser Ala Gln Gln 
        755                 760                 765             


Val Ala Val Ser Arg Leu Ser Ala Ser Ser Ser Ser Ser Asp Ser Ser 
    770                 775                 780                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Thr Ser Asp Ser Asp Ser 
785                 790                 795                 800 


Gly 
    


<210>  6
<211>  4761
<212>  DNA
<213>  Homo sapiens

<400>  6
gctcgccctc ctccctggcg ctgaccgatg gaccagccgc tccgtgggga ggactccgga       60

ccctggtggg ggggcggggg ggttctttcg cccccgtggc ggagggcccc tgagaggcgg      120

atacgggtgt gcctttgggg gtgatgtggc gtgtgggggg aaaggtccga gctcgcctgg      180

agggggaggg tttttccctt aagtcatccc tcccaggact tgctttttct gctctgagcc      240

ggacgccgga atggagtttg aggaagagat tcttcgctgc tgctgcctta ccgccgagaa      300

ccaccacccg ccaggcgtct tgcggccaca cccctggcgg gttcaggcag gctacgccca      360

cgcgacccct cccgtttccc tgctttggcc aatggaggag ctacgaatgg cacgacctgc      420

tcgagcttgg cagtctccag ttgggctgtg catggaagct tgggaagact ttgttggaag      480

gggaggcggg gagagagtgc tggaggctct ggggcgatgg cttccgcacc tcttccaacc      540

accctctttc cctggagtcg gcggaccaca gctcagccaa ttggcttgga gatgtggcgg      600

gttgccactt ccctgtgggt ctctgcggca ctcttctgcc tggtgactga caccttggaa      660

atgaagttta tgacgtcatc gttgcggctg gccaatagaa aaagctcccg cggagaggtg      720

ttccttcccc ttcgactcag cttcttcacc cgcgtgagcg agcgcgcgcg cgcggagggg      780

gtggggaaaa gctcaagcag ggtggcgcgc atgagcggcg aagctcctcc tccccgccta      840

tatataaagg gctggcgcgg ggctcggcgg cgccatttcg tgctggagtg gagcagcctc      900

tagaacgagc tggaggattc tgcctaccga tacagagcct tcgagtcgtc cggggccgcc      960

attacaatcc acctccatcc gcttggaaat ggccttcgtc ccggcctatg actggtccca     1020

gcgggcagta cagaccccct agaagcccct ggagctcccc tttttcgggc cccgcccaat     1080

cctcggagtc tgtccacccc ctctactccg ccctcaagag gatttcaaag atggaggcgg     1140

cggctcccta aaccactttt cgtgttcatc cgcctccatc cgagatcgaa acgggacctc     1200

gtcggccccg taggggcccg acaagaagag ggaatccctg cagaccaaca gcgggctata     1260

ttgacgacgg tgtctgagat cggggaccgt cttttgaaga gtcagtccct ccttagttgc     1320

ccgcctcagc tgaggccgcc gccattttct tgctgtccgc cgtctgcaga gcgcgccaag     1380

ctgcccggag ctctccgaga ggccccaaag agactgcttt cgtgccggcc aggcaggggg     1440

tttgtcgcct ggaggcccaa gaggaacggc ctccccccaa cttagcgggt tatgctggac     1500

cgggcggtga ggggaaccga ggccacccgg actttccgcg gctgagggca gcgccggttc     1560

cttgcggtca agatgctgca aaacgtgact ccccacaata agctccctgg ggaagggaat     1620

gcagggttgc tggggctggg cccagaagca gcagcaccag ggaagaggat tcgaaaaccc     1680

tctctcttgt atgagggctt tgagagcccc acaatggctt cggtgcctgc tttgcaactt     1740

acccctgcca acccaccacc cccggaggtg tccaatccca aaaagccagg acgagttacc     1800

aaccagctgc aatacctaca caaggtagtg atgaaggctc tgtggaaaca tcagttcgca     1860

tggccattcc ggcagcctgt ggatgctgtc aaactgggtc taccggatta tcacaaaatt     1920

ataaaacagc ctatggacat gggtactatt aagaggagac ttgaaaacaa ttattattgg     1980

gctgcttcag agtgtatgca agattttaat accatgttca ccaactgtta catttacaac     2040

aagcccactg atgatattgt cctaatggca caaacgctgg aaaagatatt cctacagaag     2100

gttgcatcaa tgccacaaga agaacaagag ctggtagtga ccatccctaa gaacagccac     2160

aagaaggggg ccaagttggc agcgctccag ggcagtgtta ccagtgccca tcaggtgcct     2220

gccgtctctt ctgtgtcaca cacagccctg tatactcctc cacctgagat acctaccact     2280

gtcctcaaca ttccccaccc atcagtcatt tcctctccac ttctcaagtc cttgcactct     2340

gctggacccc cgctccttgc tgttactgca gctcctccag cccagcccct tgccaagaaa     2400

aaaggcgtaa agcggaaagc agatactacc acccctacac ctacagccat cttggctcct     2460

ggttctccag ctagccctcc tgggagtctt gagcctaagg cagcacggct tccccctatg     2520

cgtagagaga gtggtcgccc catcaagccc ccacgcaaag acttgcctga ctctcagcaa     2580

caacaccaga gctctaagaa aggaaagctt tcagaacagt taaaacattg caatggcatt     2640

ttgaaggagt tactctctaa gaagcatgct gcctatgctt ggcctttcta taaaccagtg     2700

gatgcttctg cacttggcct gcatgactac catgacatca ttaagcaccc catggacctc     2760

agcactgtca agcggaagat ggagaaccgt gattaccggg atgcacagga gtttgctgct     2820

gatgtacggc ttatgttctc caactgctat aagtacaatc ccccagatca cgatgttgtg     2880

gcaatggcac gaaagctaca ggatgtattt gagttccgtt atgccaagat gccagatgaa     2940

ccactagaac cagggccttt accagtctct actgccatgc cccctggctt ggccaaatcg     3000

tcttcagagt cctccagtga ggaaagtagc agtgagagct cctctgagga agaggaggag     3060

gaagatgagg aggacgagga ggaagaagag agtgaaagct cagactcaga ggaagaaagg     3120

gctcatcgct tagcagaact acaggaacag cttcgggcag tacatgaaca actggctgct     3180

ctgtcccagg gtccaatatc caagcccaag aggaaaagag agaaaaaaga gaaaaagaag     3240

aaacggaagg cagagaagca tcgaggccga gctggggccg atgaagatga caaggggcct     3300

agggcacccc gcccacctca acctaagaag tccaagaaag caagtggcag tgggggtggc     3360

agtgctgctt taggcccttc tggctttgga ccttctggag gaagtggcac caagctcccc     3420

aaaaaggcca caaagacagc cccacctgcc ctgcctacag gttatgattc agaggaggag     3480

gaagagagca ggcccatgag ttacgatgag aagcggcagc tgagcctgga catcaacaaa     3540

ttacctgggg agaagctggg ccgagttgtg catataatcc aagccaggga gccctcttta     3600

cgtgattcaa acccagaaga gattgagatt gattttgaaa cactcaagcc atccacactt     3660

agagagcttg agcgctatgt cctttcctgc ctacgtaaga aaccccggaa gccctacacc     3720

attaagaagc ctgtgggaaa gacaaaggag gaactggctt tggagaaaaa gcgggaatta     3780

gaaaagcggt tacaagatgt cagcggacag ctcaattcta ctaaaaagcc ccccaagaaa     3840

gcgaatgaga aaacagagtc atcctctgca cagcaagtag cagtgtcacg ccttagcgct     3900

tccagctcca gctcagattc cagctcctcc tcttcctcgt cgtcgtcttc agacaccagt     3960

gattcagact caggctaagg ggtcaggcca gatggggcag gaaggctccg caggaccgga     4020

cccctagacc accctgcccc acctgcccct tccccctttg ctgtgacact tcttcatctc     4080

accccccccc gcccccctct aggagagctg gctctgcagt gggggaggga tgcagggaca     4140

tttactgaag gagggacatg gacaaaacaa cattgaattc ccagccccat tggggagtga     4200

tctcttggac acagagcccc cattcaaaat ggggcagggc aagggtggga gtgtgcaaag     4260

ccctgatctg gagttacctg aggccacagc tgccctattc acttctaagg gccctgtttt     4320

gagattgttt gttctaattt attttaagct aggtaaggct ggggggaggg tggggccgtg     4380

gtcccctcag cctccatggg gagggaagaa gggggagctc tttttttacg ttgatttttt     4440

tttttctact ctgttttccc tttttccttc cgctccattt ggggccctgg gggtttcagt     4500

catctcccca tttggtcccc tggactgtct ttgttgattc taacttgtaa ataaagaaaa     4560

tattattcaa gttttgagtt accttaatat ttgcttttgt agtgtttcaa aaggaacatc     4620

ataagaattg tcttgataat tttgagggaa atattactgc agtgagaaaa ggcaatagct     4680

aacctataat tggattgtct taatttttaa accagtaggc ttttgctgtg tttttaataa     4740

agtaaatatg acttttgtaa a                                               4761


<210>  7
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Leu Pro Ser Arg Gln Thr Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Thr Lys Lys Asn Gly Arg Leu Thr Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Thr Ile Ile Lys Asn Pro Met Asp Leu Asn Thr Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Thr Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Thr Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Thr Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


Ile Pro Ser Val Phe Pro Lys Thr Ser Ile Ser Pro Leu Asn Val Val 
            180                 185                 190         


Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Thr Ala Ala Gln Val Thr 
        195                 200                 205             


Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Ala Thr Ser Ala 
    210                 215                 220                 


Val Lys Ala Ser Ser Glu Phe Ser Pro Thr Phe Thr Glu Lys Ser Val 
225                 230                 235                 240 


Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn Val Leu Pro Asp 
                245                 250                 255     


Ser Gln Gln Gln Tyr Asn Val Val Lys Thr Val Lys Val Thr Glu Gln 
            260                 265                 270         


Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
        275                 280                 285             


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
    290                 295                 300                 


Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
305                 310                 315                 320 


Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
                325                 330                 335     


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
            340                 345                 350         


Pro Pro Asp His Glu Val Val Thr Met Ala Arg Met Leu Gln Asp Val 
        355                 360                 365             


Phe Glu Thr His Phe Ser Lys Ile Pro Ile Glu Pro Val Glu Ser Met 
    370                 375                 380                 


Pro Leu Cys Tyr Ile Lys Thr Asp Ile Thr Glu Thr Thr Gly Arg Glu 
385                 390                 395                 400 


Asn Thr Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser Asp Asp Ser Glu 
                405                 410                 415     


Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu Gln Leu Lys Ala 
            420                 425                 430         


Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro Phe Arg Lys Leu 
        435                 440                 445             


Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys Lys Glu Lys Val 
    450                 455                 460                 


Asn Asn Ser Asn Glu Asn Pro Arg Lys Met Cys Glu Gln Met Arg Leu 
465                 470                 475                 480 


Lys Glu Lys Ser Lys Arg Asn Gln Pro Lys Lys Arg Lys Gln Gln Phe 
                485                 490                 495     


Ile Gly Leu Lys Ser Glu Asp Glu Asp Asn Ala Lys Pro Met Asn Tyr 
            500                 505                 510         


Asp Glu Lys Arg Gln Leu Ser Leu Asn Ile Asn Lys Leu Pro Gly Asp 
        515                 520                 525             


Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu 
    530                 535                 540                 


Ser Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys 
545                 550                 555                 560 


Ala Ser Thr Leu Arg Glu Leu Glu Lys Tyr Val Ser Ala Cys Leu Arg 
                565                 570                 575     


Lys Arg Pro Leu Lys Pro Pro Ala Lys Lys Ile Met Met Ser Lys Glu 
            580                 585                 590         


Glu Leu His Ser Gln Lys Lys Gln Glu Leu Glu Lys Arg Leu Leu Asp 
        595                 600                 605             


Val Asn Asn Gln Leu Asn Ser Arg Lys Arg Gln Thr Lys Ser Asp Lys 
    610                 615                 620                 


Thr Gln Pro Ser Lys Ala Val Glu Asn Val Ser Arg Leu Ser Glu Ser 
625                 630                 635                 640 


Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Glu Ser Ser Ser Ser Asp 
                645                 650                 655     


Leu Ser Ser Ser Asp Ser Ser Asp Ser Glu Ser Glu Met Phe Pro Lys 
            660                 665                 670         


Phe Thr Glu Val Lys Pro Asn Asp Ser Pro Ser Lys Glu Asn Val Lys 
        675                 680                 685             


Lys Met Lys Asn Glu Cys Ile Pro Pro Glu Gly Arg Thr Gly Val Thr 
    690                 695                 700                 


Gln Ile Gly Tyr Cys Val Gln Asp Thr Thr Ser Ala Asn Thr Thr Leu 
705                 710                 715                 720 


Val His Gln Thr Thr Pro Ser His Val Met Pro Pro Asn His His Gln 
                725                 730                 735     


Leu Ala Phe Asn Tyr Gln Glu Leu Glu His Leu Gln Thr Val Lys Asn 
            740                 745                 750         


Ile Ser Pro Leu Gln Ile Leu Pro Pro Ser Gly Asp Ser Glu Gln Leu 
        755                 760                 765             


Ser Asn Gly Ile Thr Val Met His Pro Ser Gly Asp Ser Asp Thr Thr 
    770                 775                 780                 


Met Leu Glu Ser Glu Cys Gln Ala Pro Val Gln Lys Asp Ile Lys Ile 
785                 790                 795                 800 


Lys Asn Ala Asp Ser Trp Lys Ser Leu Gly Lys Pro Val Lys Pro Ser 
                805                 810                 815     


Gly Val Met Lys Ser Ser Asp Glu Leu Phe Asn Gln Phe Arg Lys Ala 
            820                 825                 830         


Ala Ile Glu Lys Glu Val Lys Ala Arg Thr Gln Glu Leu Ile Arg Lys 
        835                 840                 845             


His Leu Glu Gln Asn Thr Lys Glu Leu Lys Ala Ser Gln Glu Asn Gln 
    850                 855                 860                 


Arg Asp Leu Gly Asn Gly Leu Thr Val Glu Ser Phe Ser Asn Lys Ile 
865                 870                 875                 880 


Gln Asn Lys Cys Ser Gly Glu Glu Gln Lys Glu His Gln Gln Ser Ser 
                885                 890                 895     


Glu Ala Gln Asp Lys Ser Lys Leu Trp Leu Leu Lys Asp Arg Asp Leu 
            900                 905                 910         


Ala Arg Gln Lys Glu Gln Glu Arg Arg Arg Arg Glu Ala Met Val Gly 
        915                 920                 925             


Thr Ile Asp Met Thr Leu Gln Ser Asp Ile Met Thr Met Phe Glu Asn 
    930                 935                 940                 


Asn Phe Asp 
945         


<210>  8
<211>  3430
<212>  DNA
<213>  Homo sapiens

<400>  8
tataaaagcg cctgtcgcgc gaccgccatt acaacaaaaa ctggcggcga ggaactgcgg       60

agaactgttg ccctgcaccg cttcattttg tgcagcctga aaggggcaat cacataaggt      120

cggttttgta atatacaggt aacatacagg taatgtaccc tccacagggg gtgctgcctt      180

aggccggccc cgaggtgcgg ccttgggtgg gaacaaccgt tttttccccc ctctcccctc      240

cccgacccca tcaacatcgt gcgacagtcc gggcagttga gaaggccacc ccgcttcgtg      300

cctgcagccc agttcctctt aggtcttgga ctggtgtgga tcgctgctgc ctgtactgta      360

attttggaaa tgcaggagaa agacatgtac ttgtagacag gattcaaagc agttaagaat      420

gtctctgcca agtcgacaaa cagctattat tgttaaccct cctccaccag aatatataaa      480

tactaagaaa aatgggcgat tgacaaatca acttcagtat ctacaaaaag ttgtcctaaa      540

ggatttatgg aagcatagtt tttcatggcc ctttcaacgt cctgtggatg ctgtgaaact      600

acagttgcct gattattata ccattataaa aaacccaatg gatttaaata caattaagaa      660

gcgcttggag aataaatatt atgcgaaggc ttcagaatgt atagaagact tcaatacaat      720

gttctcaaat tgttatttat ataacaagcc tggagatgac attgttctta tggcacaagc      780

tctagagaag ctgtttatgc agaaattatc tcagatgcca caagaagagc aagttgtggg      840

tgttaaggaa agaatcaaga aaggcactca acagaatata gctgtttctt ctgctaaaga      900

aaaatcatca cccagcgcaa cagaaaaagt atttaagcag caagaaattc cttctgtatt      960

tcctaagaca tctatttctc ccttgaacgt ggtacaggga gcttcagtca actccagttc     1020

acaaactgcg gcccaagtta caaaaggtgt gaagaggaaa gcagatacaa caactcctgc     1080

aacttcagca gttaaagcaa gtagtgaatt ttctccaaca ttcacagaaa aatcagtggc     1140

actgccacct ataaaagaaa atatgccaaa gaatgttttg ccagattctc agcaacaata     1200

taatgttgtg aagactgtta aagtaactga acaattaagg cactgtagtg agattcttaa     1260

agaaatgctt gcaaagaaac atttttcata tgcatggccc ttttataatc ctgttgacgt     1320

taatgctttg ggactccata actactatga cgttgtcaaa aatccgatgg atcttggaac     1380

tattaaggag aaaatggata accaagaata taaggatgca tacaaatttg cggcagatgt     1440

tagattaatg ttcatgaatt gctacaagta caatcctcca gatcacgaag ttgtgacaat     1500

ggcaagaatg cttcaggatg ttttcgaaac gcatttttca aagatcccga ttgaacctgt     1560

tgagagtatg cctttatgtt acatcaaaac agatatcaca gaaaccactg gtagagagaa     1620

cactaatgaa gcctcctctg aagggaactc ttctgatgat tctgaagatg agcgagttaa     1680

gcgtcttgca aagcttcagg agcagcttaa agctgtacat caacagctcc aggttttgtc     1740

ccaagtacct ttccgtaagc taaataaaaa gaaagagaag tctaaaaagg aaaagaaaaa     1800

agaaaaggtt aataacagca atgaaaatcc aagaaaaatg tgtgagcaaa tgaggctaaa     1860

ggaaaagtcc aagagaaatc agccaaagaa aaggaaacaa cagttcattg gtctaaaatc     1920

tgaagatgaa gataatgcta aacctatgaa ctatgatgag aaaaggcagt taagtctgaa     1980

tataaacaaa ctccctggag ataaacttgg gcgagtagtt cacataatac aatcaagaga     2040

gccttctctg agcaattcca atcctgatga gatagagata gactttgaaa cactgaaagc     2100

atcaacacta agagaattag aaaaatatgt ttcggcatgt ctaagaaaga gaccattaaa     2160

acctcctgct aagaaaataa tgatgtccaa agaagaactt cactcacaga aaaaacagga     2220

attggaaaag cggttactgg atgttaataa tcagttaaat tctagaaaac gtcaaacaaa     2280

atctgataaa acgcaaccat ccaaagctgt tgaaaatgtt tcccgactga gtgagagcag     2340

cagcagcagc agcagctcat cagagtctga aagtagcagc agtgacttaa gctcttcaga     2400

cagcagtgat tctgaatcag aaatgttccc taagtttaca gaagtaaaac caaatgattc     2460

tccttctaaa gagaatgtaa agaaaatgaa gaatgaatgc ataccgcctg aaggaagaac     2520

aggcgtcaca cagataggat attgtgtgca agacacaacc tctgccaata ctacccttgt     2580

tcatcagacc acaccttcac atgtaatgcc accaaatcac caccaattag catttaatta     2640

tcaagaatta gaacatttac agactgtgaa aaacatttca cctttacaaa ttctgcctcc     2700

ctcaggtgat tctgaacagc tctcaaatgg cataactgtg atgcatccat ctggtgatag     2760

tgacacaacg atgttagaat ctgaatgtca agctcctgta cagaaggata taaagattaa     2820

gaatgcagat tcatggaaaa gtttaggcaa accagtgaaa ccatcaggtg taatgaaatc     2880

ctcagatgag ctcttcaacc aatttagaaa agcagccata gaaaaggaag taaaagctcg     2940

gacacaggaa ctcatacgga agcatttgga acaaaataca aaggaactaa aagcatctca     3000

agaaaatcag agggatcttg ggaatggatt gactgtagaa tctttttcaa ataaaataca     3060

aaacaagtgc tctggagaag agcagaaaga acatcagcag tcatcagaag ctcaagataa     3120

atccaaactc tggcttctca aagaccgtga tttagcaagg cagaaagaac aagagaggag     3180

gaggagagaa gcaatggtgg gtaccattga tatgaccctt caaagtgaca ttatgacaat     3240

gtttgaaaac aactttgatt aaaactcagt ttttaaatta accatcaact taaaatgaat     3300

ggtaaaagat caaaatgcat atggtaaaat gattgctttc agataacaag ataccaatct     3360

tatattgtat tttgactgct ctaaaatgat taaacagttt tcacttacat ttttaaaaaa     3420

aaaaaaaaaa                                                            3430


<210>  9
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Asn Pro Pro Pro Pro Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln 
1               5                   10                  15      


Thr Asn Gln Leu Gln Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp 
            20                  25                  30          


Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys 
        35                  40                  45              


Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met 
    50                  55                  60                  


Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln 
65                  70                  75                  80  


Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr 
                85                  90                  95      


Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys 
            100                 105                 110         


Leu Phe Leu Gln Lys Ile Asn Glu Leu Pro Thr Glu Glu 
        115                 120                 125 


<210>  10
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Asn Pro Pro Pro Pro Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln 
1               5                   10                  15      


Thr Asn Gln Leu Gln Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp 
            20                  25                  30          


Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys 
        35                  40                  45              


Leu Asn Val Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met 
    50                  55                  60                  


Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln 
65                  70                  75                  80  


Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr 
                85                  90                  95      


Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys 
            100                 105                 110         


Leu Phe Leu Gln Lys Ile Asn Glu Leu Pro Thr Glu Glu 
        115                 120                 125 


<210>  11
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Lys Asp Val Pro Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser 
1               5                   10                  15      


Lys Val Ser Glu Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met 
            20                  25                  30          


Phe Ala Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val 
        35                  40                  45              


Asp Val Glu Ala Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His 
    50                  55                  60                  


Pro Met Asp Met Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr 
65                  70                  75                  80  


Arg Asp Ala Gln Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn 
                85                  90                  95      


Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg 
            100                 105                 110         


Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu 
        115                 120                 125             


<210>  12
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Lys Asp Val Pro Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser 
1               5                   10                  15      


Lys Val Ser Glu Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met 
            20                  25                  30          


Phe Ala Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val 
        35                  40                  45              


Asp Val Glu Ala Leu Gly Val His Asp Tyr Cys Asp Ile Ile Lys His 
    50                  55                  60                  


Pro Met Asp Met Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr 
65                  70                  75                  80  


Arg Asp Ala Gln Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn 
                85                  90                  95      


Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg 
            100                 105                 110         


Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu 
        115                 120                 125             


<210>  13
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Lys Pro Gly Arg Val Thr Asn Gln Leu Gln Tyr Leu His Lys Val Val 
1               5                   10                  15      


Met Lys Ala Leu Trp Lys His Gln Phe Ala Trp Pro Phe Arg Gln Pro 
            20                  25                  30          


Val Asp Ala Val Lys Leu Gly Leu Pro Asp Tyr His Lys Ile Ile Lys 
        35                  40                  45              


Gln Pro Met Asp Met Gly Thr Ile Lys Arg Arg Leu Glu Asn Asn Tyr 
    50                  55                  60                  


Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr 
65                  70                  75                  80  


Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala 
                85                  90                  95      


Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Ser Met Pro Gln 
            100                 105                 110         


Glu Glu 
        


<210>  14
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Lys Pro Gly Arg Val Thr Asn Gln Leu Gln Tyr Leu His Lys Val Val 
1               5                   10                  15      


Met Lys Ala Leu Trp Lys His Gln Phe Ala Trp Pro Phe Arg Gln Pro 
            20                  25                  30          


Val Asp Ala Val Lys Leu Gly Val Pro Asp Tyr His Lys Ile Ile Lys 
        35                  40                  45              


Gln Pro Met Asp Met Gly Thr Ile Lys Arg Arg Leu Glu Asn Asn Tyr 
    50                  55                  60                  


Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr 
65                  70                  75                  80  


Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala 
                85                  90                  95      


Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Ser Met Pro Gln 
            100                 105                 110         


Glu Glu 
        


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Gly Lys Leu Ser Glu Gln Leu Lys His Cys Asn Gly Ile Leu Lys Glu 
1               5                   10                  15      


Leu Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro 
            20                  25                  30          


Val Asp Ala Ser Ala Leu Gly Leu His Asp Tyr His Asp Ile Ile Lys 
        35                  40                  45              


His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Glu Asn Arg Asp 
    50                  55                  60                  


Tyr Arg Asp Ala Gln Glu Phe Ala Ala Asp Val Arg Leu Met Phe Ser 
65                  70                  75                  80  


Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Asp Val Val Ala Met Ala 
                85                  90                  95      


Arg Lys Leu Gln Asp Val Phe Glu Phe Arg Tyr Ala Lys Met Pro Asp 
            100                 105                 110         


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Gly Lys Leu Ser Glu Gln Leu Lys His Cys Asn Gly Ile Leu Lys Glu 
1               5                   10                  15      


Leu Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro 
            20                  25                  30          


Val Asp Ala Ser Ala Leu Gly Val His Asp Tyr His Asp Ile Ile Lys 
        35                  40                  45              


His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Glu Asn Arg Asp 
    50                  55                  60                  


Tyr Arg Asp Ala Gln Glu Phe Ala Ala Asp Val Arg Leu Met Phe Ser 
65                  70                  75                  80  


Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Asp Val Val Ala Met Ala 
                85                  90                  95      


Arg Lys Leu Gln Asp Val Phe Glu Phe Arg Tyr Ala Lys Met Pro Asp 
            100                 105                 110         


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Pro Glu Val Ser Asn Pro Ser Lys Pro Gly Arg Lys Thr Asn Gln Leu 
1               5                   10                  15      


Gln Tyr Met Gln Asn Val Val Val Lys Thr Leu Trp Lys His Gln Phe 
            20                  25                  30          


Ala Trp Pro Phe Tyr Gln Pro Val Asp Ala Ile Lys Leu Asn Leu Pro 
        35                  40                  45              


Asp Tyr His Lys Ile Ile Lys Asn Pro Met Asp Met Gly Thr Ile Lys 
    50                  55                  60                  


Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Ser Ala Ser Glu Cys Met Gln 
65                  70                  75                  80  


Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr 
                85                  90                  95      


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Ile Phe Leu Gln 
            100                 105                 110         


Lys Val Ala Gln Met Pro Gln Glu Glu 
        115                 120     


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Pro Glu Val Ser Asn Pro Ser Lys Pro Gly Arg Lys Thr Asn Gln Leu 
1               5                   10                  15      


Gln Tyr Met Gln Asn Val Val Val Lys Thr Leu Trp Lys His Gln Phe 
            20                  25                  30          


Ala Trp Pro Phe Tyr Gln Pro Val Asp Ala Ile Lys Leu Asn Val Pro 
        35                  40                  45              


Asp Tyr His Lys Ile Ile Lys Asn Pro Met Asp Met Gly Thr Ile Lys 
    50                  55                  60                  


Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Ser Ala Ser Glu Cys Met Gln 
65                  70                  75                  80  


Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr 
                85                  90                  95      


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Ile Phe Leu Gln 
            100                 105                 110         


Lys Val Ala Gln Met Pro Gln Glu Glu 
        115                 120     


<210>  19
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg Glu 
1               5                   10                  15      


Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro 
            20                  25                  30          


Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile Lys 
        35                  40                  45              


His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg Glu 
    50                  55                  60                  


Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe Ser 
65                  70                  75                  80  


Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met Ala 
                85                  90                  95      


Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
            100                 105                 110     


<210>  20
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg Glu 
1               5                   10                  15      


Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro 
            20                  25                  30          


Val Asp Ala Glu Ala Leu Glu Val His Asp Tyr His Asp Ile Ile Lys 
        35                  40                  45              


His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg Glu 
    50                  55                  60                  


Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe Ser 
65                  70                  75                  80  


Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met Ala 
                85                  90                  95      


Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
            100                 105                 110     


<210>  21
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Asn Thr Lys Lys Asn Gly Arg Leu Thr Asn Gln Leu Gln Tyr Leu Gln 
1               5                   10                  15      


Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe Ser Trp Pro Phe 
            20                  25                  30          


Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro Asp Tyr Tyr Thr 
        35                  40                  45              


Ile Ile Lys Asn Pro Met Asp Leu Asn Thr Ile Lys Lys Arg Leu Glu 
    50                  55                  60                  


Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu Asp Phe Asn Thr 
65                  70                  75                  80  


Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly Asp Asp Ile Val 
                85                  90                  95      


Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln Lys Leu Ser Gln 
            100                 105                 110         


Met Pro Gln Glu Glu 
        115         


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Asn Thr Lys Lys Asn Gly Arg Leu Thr Asn Gln Leu Gln Tyr Leu Gln 
1               5                   10                  15      


Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe Ser Trp Pro Phe 
            20                  25                  30          


Gln Arg Pro Val Asp Ala Val Lys Leu Gln Val Pro Asp Tyr Tyr Thr 
        35                  40                  45              


Ile Ile Lys Asn Pro Met Asp Leu Asn Thr Ile Lys Lys Arg Leu Glu 
    50                  55                  60                  


Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu Asp Phe Asn Thr 
65                  70                  75                  80  


Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly Asp Asp Ile Val 
                85                  90                  95      


Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln Lys Leu Ser Gln 
            100                 105                 110         


Met Pro Gln Glu Glu 
        115         


<210>  23
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
1               5                   10                  15      


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
            20                  25                  30          


Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
        35                  40                  45              


Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
    50                  55                  60                  


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
65                  70                  75                  80  


Pro Pro Asp His Glu Val Val Thr Met Ala Arg Met Leu Gln Asp Val 
                85                  90                  95      


Phe Glu Thr His Phe 
            100     


<210>  24
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
1               5                   10                  15      


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
            20                  25                  30          


Gly Val His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
        35                  40                  45              


Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
    50                  55                  60                  


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
65                  70                  75                  80  


Pro Pro Asp His Glu Val Val Thr Met Ala Arg Met Leu Gln Asp Val 
                85                  90                  95      


Phe Glu Thr His Phe 
            100     


