                         SEQUENCE LISTING

<110>  ProMab Biotechnologies, Inc.
       Forevertek Biotechnology Co., Ltd.
 
<120>  PD-L1-SPECIFIC ANTIBODY AND ANTI-PD-L1-CAR-T CELLS

<130>  119995-8010.WO01

<150>  63/044,115
<151>  2020-06-25

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  2
<211>  366
<212>  DNA
<213>  Mus musculus

<400>  2
cagatccagt tggtgcagtc tggacctgag ctgaagaacc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatggggtgg ataaacaccc acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tcttcggaaa cctctgccag ctctgcctat      240

ttgcagatca acaacctcaa aaatgatgac atggctacat atttctgtgc aaaaggtacc      300

cacagagaag aaattccggc ctggttcgct tactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  3
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  3

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Asn Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Ser Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Asp Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Thr His Arg Glu Glu Ile Pro Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  4
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  4
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccagag ctcctgatct acaaagtttc caacctattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cccacgttcg gtgctgggac caagctggag ctgaaacgg                             339


<210>  5
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Glu Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  6
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
ggtggcggtg gttctggtgg cggtggttct ggtggcggtg gttct                       45


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  8
<211>  750
<212>  DNA
<213>  Mus musculus

<400>  8
cagatccagt tggtgcagtc tggacctgag ctgaagaacc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatggggtgg ataaacaccc acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tcttcggaaa cctctgccag ctctgcctat      240

ttgcagatca acaacctcaa aaatgatgac atggctacat atttctgtgc aaaaggtacc      300

cacagagaag aaattccggc ctggttcgct tactggggcc aagggactct ggtcactgtc      360

tctgcaggtg gcggtggttc tggtggcggt ggttctggtg gcggtggttc tgatgttttg      420

atgacccaaa ctccactctc cctgcctgtc agtcttggag atcaagcctc catctcttgc      480

agatctagtc agagcattgt acatagtaat ggaaacacct atttagaatg gtacctgcag      540

aaaccaggcc agtctccaga gctcctgatc tacaaagttt ccaacctatt ttctggggtc      600

ccagacaggt tcagtggcag tggatcaggg acagatttca cactcaagat cagcagagtg      660

gaggctgagg atctgggagt ttattactgc tttcaaggtt cacatgttcc tcccacgttc      720

ggtgctggga ccaagctgga gctgaaacgg                                       750


<210>  9
<211>  250
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Asn Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Ser Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Asp Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Thr His Arg Glu Glu Ile Pro Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Met Thr Gln Thr 
    130                 135                 140                 


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile Tyr Lys 
            180                 185                 190         


Val Ser Asn Leu Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Pro Thr Phe 
225                 230                 235                 240 


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
                245                 250 


<210>  10
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  10
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
gactacaaag acgatgacga caag                                              24


<210>  13
<211>  141
<212>  DNA
<213>  Homo sapiens

<400>  13
aagcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag       60

cccctgtccc tgcgcccaga ggcgagccgg ccagcggcgg ggggcgcagt gcacacgagg      120

gggctggact tcgccagtga t                                                141


<210>  14
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
        35                  40                  45          


<210>  15
<211>  204
<212>  DNA
<213>  Homo sapiens

<400>  15
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      120

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      180

cgcgacttcg cagcctatcg ctcc                                             204


<210>  16
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  17
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  17
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                         342


<210>  18
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  19
<211>  1542
<212>  DNA
<213>  Mus musculus

<400>  19
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagcc agatccagtt ggtgcagtct ggacctgagc tgaagaaccc tggagagaca      120

gtcaagatct cctgcaaggc ttctgggtat accttcacaa actatggaat gaactgggtg      180

aagcaggctc caggaaaggg tttaaagtgg atggggtgga taaacaccca cactggagag      240

ccaacatatg ctgatgactt caagggacgg tttgccttct cttcggaaac ctctgccagc      300

tctgcctatt tgcagatcaa caacctcaaa aatgatgaca tggctacata tttctgtgca      360

aaaggtaccc acagagaaga aattccggcc tggttcgctt actggggcca agggactctg      420

gtcactgtct ctgcaggtgg cggtggttct ggtggcggtg gttctggtgg cggtggttct      480

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      540

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      600

tacctgcaga aaccaggcca gtctccagag ctcctgatct acaaagtttc caacctattt      660

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      720

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      780

cccacgttcg gtgctgggac caagctggag ctgaaacggg actacaaaga cgatgacgac      840

aagctcgaga agcccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      900

gcgtcgcagc ccctgtccct gcgcccagag gcgagccggc cagcggcggg gggcgcagtg      960

cacacgaggg ggctggactt cgccagtgat aagccctttt gggtgctggt ggtggttggt     1020

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg     1080

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg     1140

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1200

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1260

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1320

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac     1380

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1440

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1500

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1542


<210>  20
<211>  512
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Gln Ile Gln Leu Val Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Lys Asn Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr His Thr Gly Glu 
65                  70                  75                  80  


Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Ser Glu 
                85                  90                  95      


Thr Ser Ala Ser Ser Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Asp 
            100                 105                 110         


Asp Met Ala Thr Tyr Phe Cys Ala Lys Gly Thr His Arg Glu Glu Ile 
        115                 120                 125             


Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
                165                 170                 175     


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            180                 185                 190         


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Glu Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
225                 230                 235                 240 


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                245                 250                 255     


Ser His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            260                 265                 270         


Arg Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Lys Pro Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys Pro Phe Trp Val Leu 
                325                 330                 335     


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            340                 345                 350         


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
        355                 360                 365             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
    370                 375                 380                 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


<210>  21
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  21
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  22
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  23
<211>  1521
<212>  DNA
<213>  Mus musculus

<400>  23
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagcc agatccagtt ggtgcagtct ggacctgagc tgaagaaccc tggagagaca      120

gtcaagatct cctgcaaggc ttctgggtat accttcacaa actatggaat gaactgggtg      180

aagcaggctc caggaaaggg tttaaagtgg atggggtgga taaacaccca cactggagag      240

ccaacatatg ctgatgactt caagggacgg tttgccttct cttcggaaac ctctgccagc      300

tctgcctatt tgcagatcaa caacctcaaa aatgatgaca tggctacata tttctgtgca      360

aaaggtaccc acagagaaga aattccggcc tggttcgctt actggggcca agggactctg      420

gtcactgtct ctgcaggtgg cggtggttct ggtggcggtg gttctggtgg cggtggttct      480

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      540

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      600

tacctgcaga aaccaggcca gtctccagag ctcctgatct acaaagtttc caacctattt      660

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      720

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      780

cccacgttcg gtgctgggac caagctggag ctgaaacggc tcgagaagcc caccacgacg      840

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      900

ccagaggcga gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      960

agtgataagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg     1020

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat     1080

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1140

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1200

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1260

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1320

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1380

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1440

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1500

caggccctgc cccctcgcta a                                               1521


<210>  24
<211>  506
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Gln Ile Gln Leu Val Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Lys Asn Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr His Thr Gly Glu 
65                  70                  75                  80  


Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Ser Glu 
                85                  90                  95      


Thr Ser Ala Ser Ser Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Asp 
            100                 105                 110         


Asp Met Ala Thr Tyr Phe Cys Ala Lys Gly Thr His Arg Glu Glu Ile 
        115                 120                 125             


Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
                165                 170                 175     


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            180                 185                 190         


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Glu Leu Leu Ile Tyr Lys Val Ser Asn Leu Phe Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
225                 230                 235                 240 


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                245                 250                 255     


Ser His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            260                 265                 270         


Arg Leu Glu Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Ser Asp Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505     


<210>  25
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  25
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatatta tgatgtgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcagc atttatccga gcggcggcat taccttttat      180

gcggataccg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcattaaa      300

ctgggcaccg tgaccaccgt ggattattgg ggccagggca ccctggtgac cgtgagcagc      360


<210>  26
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  27
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagc                       45


<210>  28
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  28
cagagcgcgc tgacccagcc ggcgagcgtg agcggcagcc cgggccagag cattaccatt       60

agctgcaccg gcaccagcag cgatgtgggc ggctataact atgtgagctg gtatcagcag      120

catccgggca aagcgccgaa actgatgatt tatgatgtga gcaaccgccc gagcggcgtg      180

agcaaccgct ttagcggcag caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caggcggaag atgaagcgga ttattattgc agcagctata ccagcagcag cacccgcgtg      300

tttggcaccg gcaccaaagt gaccgtgctg                                       330


<210>  29
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Glu Thr Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr 
                85                  90                  95      


Ser Ser Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  30
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  30
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatatta tgatgtgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcagc atttatccga gcggcggcat taccttttat      180

gcggataccg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcattaaa      300

ctgggcaccg tgaccaccgt ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagccagag cgcgctgacc      420

cagccggcga gcgtgagcgg cagcccgggc cagagcatta ccattagctg caccggcacc      480

agcagcgatg tgggcggcta taactatgtg agctggtatc agcagcatcc gggcaaagcg      540

ccgaaactga tgatttatga tgtgagcaac cgcccgagcg gcgtgagcaa ccgctttagc      600

ggcagcaaaa gcggcaacac cgcgagcctg accattagcg gcctgcaggc ggaagatgaa      660

gcggattatt attgcagcag ctataccagc agcagcaccc gcgtgtttgg caccggcacc      720

aaagtgaccg tgctg                                                       735


<210>  31
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser 
    130                 135                 140                 


Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 
145                 150                 155                 160 


Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro 
            180                 185                 190         


Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
        195                 200                 205             


Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val Phe Gly Thr Gly Thr 
225                 230                 235                 240 


Lys Val Thr Val Leu 
                245 


