                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       CARMI, Yaron
       RIDER, Peleg
       RASOULOUNIRIANA, Diana
       TAL, Lior
 
<120>  MULTI SUBUNIT PROTEIN MODULES, CELLS EXPRESSING SAME AND USES 
       THEREOF

<130>  88183

<150>  US 63/042,080
<151>  2020-06-22

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alpha-2A-gamma construct aa seequence (mouse origin)

<400>  1

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro 
                325                 330                 335     


Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg 
            340                 345                 350         


Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr 
        355                 360                 365             


Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly 
    370                 375                 380                 


Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln 
385                 390                 395                 400 


Thr Ser Gln Ser Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                405                 410                 415     


Glu Glu Asn Pro Gly Pro Met Ile Ser Ala Val Ile Leu Phe Leu Leu 
            420                 425                 430         


Leu Leu Val Glu Gln Ala Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr 
        435                 440                 445             


Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu 
    450                 455                 460                 


Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Ala Ser Arg 
465                 470                 475                 480 


Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu 
                485                 490                 495     


Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
            500                 505             


<210>  2
<211>  1527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alpha-2A-gamma construct NA sequqence (mouse origin)

<400>  2
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

aaaatacaca ggctgcagag agagaagaaa tacaacttag aagtcccttt ggtttctgag     1020

cagggaaaga aagcaaattc ctttcagcaa gttagaagcg atggcgtgta tgaagaagta     1080

acagccactg cgagccagac cacaccaaaa gaagcgcccg atggacctcg aagctcagtg     1140

ggtgactgtg gacccgagca gcctgaaccc cttcctccca gtgacagtac tggggcacaa     1200

acttcccaaa gtgagggcag aggaagtctg ctaacatgcg gtgacgtcga ggagaatcct     1260

ggcccaatga tctcagccgt gatcttgttc ttgctccttt tggtggaaca agcagccgcc     1320

ctgggagagc cgcagctctg ctatatcctg gatgctgtcc tgtttttgta tggtattgtc     1380

cttaccctac tctactgtcg actcaagatc caggtccgaa aggcagctat agccagccgt     1440

gagaaagcag atgctgtcta cacgggcctg aacacccgga gccaggagac atatgagact     1500

ctgaagcatg agaaaccacc ccagtag                                         1527


<210>  3
<211>  466
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alpha-gamma 2A-gamma construct aa seequence (mouse origin)

<400>  3

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys 
                325                 330                 335     


Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr 
            340                 345                 350         


Glu Thr Leu Lys His Glu Lys Pro Pro Gln Glu Gly Arg Gly Ser Leu 
        355                 360                 365             


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile Ser Ala 
    370                 375                 380                 


Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala Ala Ala Leu Gly 
385                 390                 395                 400 


Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly 
                405                 410                 415     


Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys 
            420                 425                 430         


Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu 
        435                 440                 445             


Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro 
    450                 455                 460                 


Pro Gln 
465     


<210>  4
<211>  1398
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alpha-gamma 2A-gamma construct na seequence (mouse origin)

<400>  4
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

cgactcaaga tccaggtccg aaaggcagct atagccagcc gtgagaaagc agatgctgtc     1020

tacacgggcc tgaacacccg gagccaggag acatatgaga ctctgaagca tgagaaacca     1080

ccccaggagg gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggccca     1140

atgatctcag ccgtgatctt gttcttgctc cttttggtgg aacaagcagc cgccctggga     1200

gagccgcagc tctgctatat cctggatgct gtcctgtttt tgtatggtat tgtccttacc     1260

ctactctact gtcgactcaa gatccaggtc cgaaaggcag ctatagccag ccgtgagaaa     1320

gcagatgctg tctacacggg cctgaacacc cggagccagg agacatatga gactctgaag     1380

catgagaaac caccccag                                                   1398


<210>  5
<211>  405
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alpha-CD8-gamma construct aa sequence (mouse origin)

<400>  5

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Thr Thr Thr Lys Pro Val Leu 
    290                 295                 300                 


Arg Thr Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg 
305                 310                 315                 320 


Pro Glu Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp 
                325                 330                 335     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val 
            340                 345                 350         


Ala Leu Leu Leu Ser Leu Ile Ile Thr Leu Ile Arg Leu Lys Ile Gln 
        355                 360                 365             


Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr 
    370                 375                 380                 


Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys His 
385                 390                 395                 400 


Glu Lys Pro Pro Gln 
                405 


<210>  6
<211>  1218
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alpha-CD8-gamma construct aa sequence (mouse origin)

<400>  6
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tactactacc      900

aagccagtgc tgcgaactcc ctcacctgtg caccctaccg ggacatctca gccccagaga      960

ccagaagatt gtcggccccg tggctcagtg aaggggaccg gattggactt cgcctgtgat     1020

atttacatct gggcaccctt ggccggaatc tgcgtggccc ttctgctgtc cttgatcatc     1080

actctcatcc gactcaagat ccaggtccga aaggcagcta tagccagccg tgagaaagca     1140

gatgctgtct acacgggcct gaacacccgg agccaggaga catatgagac tctgaagcat     1200

gagaaaccac cccagtag                                                   1218


<210>  7
<211>  466
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alpha-gamma-2A-Gamma(mut) construct AA sequence (mouse origin)

<400>  7

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys 
                325                 330                 335     


Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr 
            340                 345                 350         


Glu Thr Leu Lys His Glu Lys Pro Pro Gln Glu Gly Arg Gly Ser Leu 
        355                 360                 365             


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile Ser Ala 
    370                 375                 380                 


Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala Ala Ala Leu Gly 
385                 390                 395                 400 


Glu Pro Gln Leu Gly Tyr Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly 
                405                 410                 415     


Ile Val Leu Thr Leu Leu Tyr Gly Arg Leu Lys Ile Gln Val Arg Lys 
            420                 425                 430         


Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu 
        435                 440                 445             


Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro 
    450                 455                 460                 


Pro Gln 
465     


<210>  8
<211>  1656
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alpha-gamma-2A-Gamma(mut) construct NA sequence (mouse origin)

<400>  8
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

cgactcaaga tccaggtccg aaaggcagct atagccagcc gtgagaaagc agatgctgtc     1020

tacacgggcc tgaacacccg gagccaggag acatatgaga ctctgaagca tgagaaacca     1080

ccccaggagg gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggccca     1140

atgatctcag ccgtgatctt gttcttgctc cttttggtgg aacaagcagc cgccctggga     1200

gagccgcagc tcggctatat cctggatgct gtcctgtttt tgtatggtat tgtccttacc     1260

ctactctacg gtcgactcaa gatccaggtc cgaaaggcag ctatagccag ccgtgagaaa     1320

gcagatgctg tctacacggg cctgaacacc cggagccagg agacatatga gactctgaag     1380

catgagaaac caccccagat gatctcagcc gtgatcttgt tcttgctcct tttggtggaa     1440

caagcagccg ccctgggaga gccgcagctc tgctatatcc tggatgctgt cctgtttttg     1500

tatggtattg tccttaccct actctactgt cgactcaaga tccaggtccg aaaggcagct     1560

atagccagcc gtgagaaagc agatgctgtc tacacgggcc tgaacacccg gagccaggag     1620

acatatgaga ctctgaagca tgagaaacca ccccag                               1656


<210>  9
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
aataacacta gtgccaccat gcctgaaccg gcaaaat                                37


<210>  10
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
aacaaccccg ggacttgtcg tcatcgtctt tgt                                    33


<210>  11
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  12
<211>  42
<212>  PRT
<213>  mus musculus

<400>  12

Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys 
1               5                   10                  15      


Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210>  13
<211>  126
<212>  DNA
<213>  mus musculus

<400>  13
cgactcaaga tccaggtccg aaaggcagct atagccagcc gtgagaaagc agatgctgtc       60

tacacgggcc tgaacacccg gagccaggag acatatgaga ctctgaagca tgagaaacca      120

ccccag                                                                 126


<210>  14
<211>  273
<212>  PRT
<213>  mus musculus

<400>  14

Glu Val Val Asn Ala Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp 
1               5                   10                  15      


Val Ser Ile Phe Gln Lys Glu Asn Val Thr Leu Trp Cys Glu Gly Pro 
            20                  25                  30          


His Leu Pro Gly Asp Ser Ser Thr Gln Trp Phe Ile Asn Gly Thr Ala 
        35                  40                  45              


Val Gln Ile Ser Thr Pro Ser Tyr Ser Ile Pro Glu Ala Ser Phe Gln 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Ile Gly Ser Ser Met Pro Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Gln Ile His Asn Asp Trp Leu Leu Leu Gln Ala Ser 
                85                  90                  95      


Arg Arg Val Leu Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Gly 
            100                 105                 110         


Trp Lys Asn Lys Leu Val Tyr Asn Val Val Phe Tyr Arg Asn Gly Lys 
        115                 120                 125             


Ser Phe Gln Phe Ser Ser Asp Ser Glu Val Ala Ile Leu Lys Thr Asn 
    130                 135                 140                 


Leu Ser His Ser Gly Ile Tyr His Cys Ser Gly Thr Gly Arg His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Val Ser Ile Thr Val Lys Glu Leu Phe Thr Thr 
                165                 170                 175     


Pro Val Leu Arg Ala Ser Val Ser Ser Pro Phe Pro Glu Gly Ser Leu 
            180                 185                 190         


Val Thr Leu Asn Cys Glu Thr Asn Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu His Phe Ser Phe Tyr Val Gly Ser Lys Ile Leu Glu Tyr Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr His Ile Ala Arg Ala Glu Arg Glu Asp Ala 
225                 230                 235                 240 


Gly Phe Tyr Trp Cys Glu Val Ala Thr Glu Asp Ser Ser Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Pro Gln Ser Ser Ala 
            260                 265                 270         


Pro 
    


<210>  15
<211>  819
<212>  DNA
<213>  mus musculus

<400>  15
gaagtggtta atgccaccaa ggctgtgatc accttgcagc ctccatgggt cagtattttc       60

cagaaggaaa atgtcacttt atggtgtgag gggcctcacc tgcctggaga cagttccaca      120

caatggttta tcaacggaac agccgttcag atctccacgc ctagttatag catcccagag      180

gccagttttc aggacagtgg cgaatacagg tgtcagatag gttcctcaat gccaagtgac      240

cctgtgcagt tgcaaatcca caatgattgg ctgctactcc aggcctcccg cagagtcctc      300

acagaaggag aacccctggc cttgaggtgt cacggatgga agaataaact ggtgtacaat      360

gtggttttct atagaaatgg aaaatccttt cagttttctt cagattcgga ggtcgccatt      420

ctgaaaacca acctgagtca cagcggcatc taccactgct caggcacggg aagacaccgc      480

tacacatctg caggagtgtc catcacggtg aaagagctgt ttaccacgcc agtgctgaga      540

gcatccgtgt catctccctt cccggagggg agtctggtca ccctgaactg tgagacgaat      600

ttgctcctgc agagacccgg cttacagctt cacttctcct tctacgtggg cagcaagatc      660

ctggagtaca ggaacacatc ctcagagtac catatagcaa gggcggaaag agaagatgct      720

ggattctact ggtgtgaggt agccacggag gacagcagtg tccttaagcg cagccctgag      780

ttggagctcc aagtgcttgg tccccagtca tcagctcct                             819


<210>  16
<211>  23
<212>  PRT
<213>  mus musculus

<400>  16

Val Trp Phe His Ile Leu Phe Tyr Leu Ser Val Gly Ile Met Phe Ser 
1               5                   10                  15      


Leu Asn Thr Val Leu Tyr Val 
            20              


<210>  17
<211>  69
<212>  DNA
<213>  mus musculus

<400>  17
gtctggtttc acatcctgtt ttatctgtca gtgggaataa tgttttcgtt gaacacggtt       60

ctctatgtg                                                               69


<210>  18
<211>  296
<212>  PRT
<213>  mus musculus

<400>  18

Glu Val Val Asn Ala Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp 
1               5                   10                  15      


Val Ser Ile Phe Gln Lys Glu Asn Val Thr Leu Trp Cys Glu Gly Pro 
            20                  25                  30          


His Leu Pro Gly Asp Ser Ser Thr Gln Trp Phe Ile Asn Gly Thr Ala 
        35                  40                  45              


Val Gln Ile Ser Thr Pro Ser Tyr Ser Ile Pro Glu Ala Ser Phe Gln 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Ile Gly Ser Ser Met Pro Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Gln Ile His Asn Asp Trp Leu Leu Leu Gln Ala Ser 
                85                  90                  95      


Arg Arg Val Leu Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Gly 
            100                 105                 110         


Trp Lys Asn Lys Leu Val Tyr Asn Val Val Phe Tyr Arg Asn Gly Lys 
        115                 120                 125             


Ser Phe Gln Phe Ser Ser Asp Ser Glu Val Ala Ile Leu Lys Thr Asn 
    130                 135                 140                 


Leu Ser His Ser Gly Ile Tyr His Cys Ser Gly Thr Gly Arg His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Val Ser Ile Thr Val Lys Glu Leu Phe Thr Thr 
                165                 170                 175     


Pro Val Leu Arg Ala Ser Val Ser Ser Pro Phe Pro Glu Gly Ser Leu 
            180                 185                 190         


Val Thr Leu Asn Cys Glu Thr Asn Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu His Phe Ser Phe Tyr Val Gly Ser Lys Ile Leu Glu Tyr Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr His Ile Ala Arg Ala Glu Arg Glu Asp Ala 
225                 230                 235                 240 


Gly Phe Tyr Trp Cys Glu Val Ala Thr Glu Asp Ser Ser Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Pro Gln Ser Ser Ala 
            260                 265                 270         


Pro Val Trp Phe His Ile Leu Phe Tyr Leu Ser Val Gly Ile Met Phe 
        275                 280                 285             


Ser Leu Asn Thr Val Leu Tyr Val 
    290                 295     


<210>  19
<211>  338
<212>  PRT
<213>  mus musculus

<400>  19

Glu Val Val Asn Ala Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp 
1               5                   10                  15      


Val Ser Ile Phe Gln Lys Glu Asn Val Thr Leu Trp Cys Glu Gly Pro 
            20                  25                  30          


His Leu Pro Gly Asp Ser Ser Thr Gln Trp Phe Ile Asn Gly Thr Ala 
        35                  40                  45              


Val Gln Ile Ser Thr Pro Ser Tyr Ser Ile Pro Glu Ala Ser Phe Gln 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Ile Gly Ser Ser Met Pro Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Gln Ile His Asn Asp Trp Leu Leu Leu Gln Ala Ser 
                85                  90                  95      


Arg Arg Val Leu Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Gly 
            100                 105                 110         


Trp Lys Asn Lys Leu Val Tyr Asn Val Val Phe Tyr Arg Asn Gly Lys 
        115                 120                 125             


Ser Phe Gln Phe Ser Ser Asp Ser Glu Val Ala Ile Leu Lys Thr Asn 
    130                 135                 140                 


Leu Ser His Ser Gly Ile Tyr His Cys Ser Gly Thr Gly Arg His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Val Ser Ile Thr Val Lys Glu Leu Phe Thr Thr 
                165                 170                 175     


Pro Val Leu Arg Ala Ser Val Ser Ser Pro Phe Pro Glu Gly Ser Leu 
            180                 185                 190         


Val Thr Leu Asn Cys Glu Thr Asn Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu His Phe Ser Phe Tyr Val Gly Ser Lys Ile Leu Glu Tyr Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr His Ile Ala Arg Ala Glu Arg Glu Asp Ala 
225                 230                 235                 240 


Gly Phe Tyr Trp Cys Glu Val Ala Thr Glu Asp Ser Ser Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Pro Gln Ser Ser Ala 
            260                 265                 270         


Pro Val Trp Phe His Ile Leu Phe Tyr Leu Ser Val Gly Ile Met Phe 
        275                 280                 285             


Ser Leu Asn Thr Val Leu Tyr Val Arg Leu Lys Ile Gln Val Arg Lys 
    290                 295                 300                 


Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu 
305                 310                 315                 320 


Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro 
                325                 330                 335     


Pro Gln 
        


<210>  20
<211>  1014
<212>  DNA
<213>  mus musculus

<400>  20
gaagtggtta atgccaccaa ggctgtgatc accttgcagc ctccatgggt cagtattttc       60

cagaaggaaa atgtcacttt atggtgtgag gggcctcacc tgcctggaga cagttccaca      120

caatggttta tcaacggaac agccgttcag atctccacgc ctagttatag catcccagag      180

gccagttttc aggacagtgg cgaatacagg tgtcagatag gttcctcaat gccaagtgac      240

cctgtgcagt tgcaaatcca caatgattgg ctgctactcc aggcctcccg cagagtcctc      300

acagaaggag aacccctggc cttgaggtgt cacggatgga agaataaact ggtgtacaat      360

gtggttttct atagaaatgg aaaatccttt cagttttctt cagattcgga ggtcgccatt      420

ctgaaaacca acctgagtca cagcggcatc taccactgct caggcacggg aagacaccgc      480

tacacatctg caggagtgtc catcacggtg aaagagctgt ttaccacgcc agtgctgaga      540

gcatccgtgt catctccctt cccggagggg agtctggtca ccctgaactg tgagacgaat      600

ttgctcctgc agagacccgg cttacagctt cacttctcct tctacgtggg cagcaagatc      660

ctggagtaca ggaacacatc ctcagagtac catatagcaa gggcggaaag agaagatgct      720

ggattctact ggtgtgaggt agccacggag gacagcagtg tccttaagcg cagccctgag      780

ttggagctcc aagtgcttgg tccccagtca tcagctcctg tctggtttca catcctgttt      840

tatctgtcag tgggaataat gttttcgttg aacacggttc tctatgtgcg actcaagatc      900

caggtccgaa aggcagctat agccagccgt gagaaagcag atgctgtcta cacgggcctg      960

aacacccgga gccaggagac atatgagact ctgaagcatg agaaaccacc ccag           1014


<210>  21
<211>  21
<212>  PRT
<213>  mus musculus

<400>  21

Leu Cys Tyr Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys 
            20      


<210>  22
<211>  63
<212>  DNA
<213>  mus musculus

<400>  22
ctctgctata tcctggatgc tgtcctgttt ttgtatggta ttgtccttac cctactctac       60

tgt                                                                     63


<210>  23
<211>  63
<212>  PRT
<213>  mus musculus

<400>  23

Leu Cys Tyr Ile Leu Asp Ala Val Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile 
            20                  25                  30          


Ala Ser Arg Glu Lys Ala Asp Ala Val Tyr Thr Gly Leu Asn Thr Arg 
        35                  40                  45              


Ser Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
    50                  55                  60              


<210>  24
<211>  189
<212>  DNA
<213>  mus musculus

<400>  24
ctctgctata tcctggatgc tgtcctgttt ttgtatggta ttgtccttac cctactctac       60

tgtcgactca agatccaggt ccgaaaggca gctatagcca gccgtgagaa agcagatgct      120

gtctacacgg gcctgaacac ccggagccag gagacatatg agactctgaa gcatgagaaa      180

ccaccccag                                                              189


<210>  25
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40 intracellular domain AA sequence

<400>  25

Arg Lys Ala Trp Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn 
1               5                   10                  15      


Ser Phe Arg Thr Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr 
            20                  25                  30          


Leu Ala Lys Ile 
        35      


<210>  26
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB intracellular domain AA sequence

<400>  26

Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
1               5                   10                  15      


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
            20                  25                  30          


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
        35                  40                  45              


<210>  27
<211>  85
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-2R common gamma intracellular AA sequence

<400>  27

Glu Arg Met Pro Pro Ile Pro Pro Ile Lys Asn Leu Glu Asp Leu Val 
1               5                   10                  15      


Thr Glu Tyr Gln Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly 
            20                  25                  30          


Leu Thr Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Phe Cys His Val 
        35                  40                  45              


Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Gly 
    50                  55                  60                  


Ser Pro Cys Ser Leu His Ser Pro Tyr Trp Pro Pro Pro Cys Tyr Ser 
65                  70                  75                  80  


Leu Lys Pro Glu Ala 
                85  


<210>  28
<211>  186
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TNFR2 intracellular signaling domain AA SEQUENCE

<400>  28

Lys Lys Lys Pro Ser Cys Leu Gln Arg Asp Ala Lys Val Pro His Val 
1               5                   10                  15      


Pro Asp Glu Lys Ser Gln Asp Ala Val Gly Leu Glu Gln Gln His Leu 
            20                  25                  30          


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
        35                  40                  45              


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
    50                  55                  60                  


Val Met Ala Glu Ala Gln Gly Phe Gln Glu Ala Arg Ala Ser Ser Arg 
65                  70                  75                  80  


Ile Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
                85                  90                  95      


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
            100                 105                 110         


Ser Gln Ala Ser Ala Thr Val Gly Asp Pro Asp Ala Lys Pro Ser Ala 
        115                 120                 125             


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
    130                 135                 140                 


Gln Ser Pro Cys Glu Thr Thr Glu Thr Leu Gln Ser His Glu Lys Pro 
145                 150                 155                 160 


Leu Pro Leu Gly Val Pro Asp Met Gly Met Lys Pro Ser Gln Ala Gly 
                165                 170                 175     


Trp Phe Asp Gln Ile Ala Val Lys Val Ala 
            180                 185     


<210>  29
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-12Rb1 intracellular AA SEQUENCE

<400>  29

Asn Arg Ala Ala Trp His Leu Cys Pro Pro Leu Pro Thr Pro Cys Gly 
1               5                   10                  15      


Ser Thr Ala Val Glu Phe Pro Gly Ser Gln Gly Lys Gln Ala Trp Gln 
            20                  25                  30          


Trp Cys Asn Pro Glu Asp Phe Pro Glu Val Leu Tyr Pro Arg Asp Ala 
        35                  40                  45              


Leu Val Val Glu Met Pro Gly Asp Arg Gly Asp Gly Thr Glu Ser Pro 
    50                  55                  60                  


Gln Ala Ala Pro Glu Cys Ala Leu Asp Thr Arg Arg Pro Leu Glu Thr 
65                  70                  75                  80  


Gln Arg Gln Arg Gln Val Gln Ala Leu Ser Glu Ala Arg Arg Leu Gly 
                85                  90                  95      


Leu Ala Arg Glu Asp Cys Pro Arg Gly Asp Leu Ala His Val Thr Leu 
            100                 105                 110         


Pro Leu Leu Leu Gly Gly Val Thr Gln Gly Ala Ser Val Leu Asp Asp 
        115                 120                 125             


Leu Trp Arg Thr His Lys Thr Ala Glu Pro Gly Pro Pro Thr Leu Gly 
    130                 135                 140                 


Gln Glu Ala 
145         


<210>  30
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-12Rb2 intracellular AA SEQUENCE

<400>  30

Arg Tyr Phe Arg Gln Lys Ala Phe Thr Leu Leu Ser Thr Leu Lys Pro 
1               5                   10                  15      


Gln Trp Tyr Ser Arg Thr Ile Pro Asp Pro Ala Asn Ser Thr Trp Val 
            20                  25                  30          


Lys Lys Tyr Pro Ile Leu Glu Glu Lys Ile Gln Leu Pro Thr Asp Asn 
        35                  40                  45              


Leu Leu Met Ala Trp Pro Thr Pro Glu Glu Pro Glu Pro Leu Ile Ile 
    50                  55                  60                  


His Glu Val Leu Tyr His Met Ile Pro Val Val Arg Gln Pro Tyr Tyr 
65                  70                  75                  80  


Phe Lys Arg Gly Gln Gly Phe Gln Gly Tyr Ser Thr Ser Lys Gln Asp 
                85                  90                  95      


Ala Met Tyr Ile Ala Asn Pro Gln Ala Thr Gly Thr Leu Thr Ala Glu 
            100                 105                 110         


Thr Arg Gln Leu Val Asn Leu Tyr Lys Val Leu Glu Ser Arg Asp Pro 
        115                 120                 125             


Asp Ser Lys Leu Ala Asn Leu Thr Ser Pro Leu Thr Val Thr Pro Val 
    130                 135                 140                 


Asn Tyr Leu Pro Ser His Glu Gly Tyr Leu Pro Ser Asn Ile Glu Asp 
145                 150                 155                 160 


Leu Ser Pro His Glu Ala Asp Pro Thr Asp Ser Phe Asp Leu Glu His 
                165                 170                 175     


Gln His Ile Ser Leu Ser Ile Phe Ala Ser Ser Ser Leu Arg Pro Leu 
            180                 185                 190         


Ile Phe Gly Gly Glu Arg Leu Thr Leu Asp Arg Leu Lys Met Gly Tyr 
        195                 200                 205             


Asp Ser Leu Met Ser Asn Glu Ala 
    210                 215     


<210>  31
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-23R intracellular  AA SEQUENCE

<400>  31

Asn Arg Ser Leu Arg Ile Gly Ile Lys Arg Lys Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Lys Trp Leu Tyr Glu Asp Ile Pro Asn Met Glu Asn Ser Asn Val 
            20                  25                  30          


Ala Lys Leu Leu Gln Glu Lys Ser Val Phe Glu Asn Asp Asn Ala Ser 
        35                  40                  45              


Glu Gln Ala Leu Tyr Val Asp Pro Val Leu Thr Glu Ile Ser Glu Ile 
    50                  55                  60                  


Ser Pro Leu Glu His Lys Pro Thr Asp Tyr Lys Glu Glu Arg Leu Thr 
65                  70                  75                  80  


Gly Leu Leu Glu Thr Arg Asp Cys Pro Leu Gly Met Leu Ser Thr Ser 
                85                  90                  95      


Ser Ser Val Val Tyr Ile Pro Asp Leu Asn Thr Gly Tyr Lys Pro Gln 
            100                 105                 110         


Val Ser Asn Val Pro Pro Gly Gly Asn Leu Phe Ile Asn Arg Asp Glu 
        115                 120                 125             


Arg Asp Pro Thr Ser Leu Glu Thr Thr Asp Asp His Phe Ala Arg Leu 
    130                 135                 140                 


Lys Thr Tyr Pro Asn Phe Gln Phe Ser Ala Ser Ser Met Ala Leu Leu 
145                 150                 155                 160 


Asn Lys Thr Leu Ile Leu Asp Glu Leu Cys Leu Val Leu Asn Gln Gly 
                165                 170                 175     


Glu Phe Asn Ser Leu Asp Ile Lys Asn Ser Arg Gln Glu Glu Thr Ser 
            180                 185                 190         


Ile Val Leu Gln Ser Asp Ser Pro Ser Glu Thr Ile Pro Ala Gln Thr 
        195                 200                 205             


Leu Leu Ser Asp Glu Phe Val Ser Cys Leu Ala Ile Gly Asn Glu Asp 
    210                 215                 220                 


Leu Pro Ser Ile Asn Ser Tyr Phe Pro Gln Asn Val Leu Glu Ser His 
225                 230                 235                 240 


Phe Ser Arg Ile Ser Leu Phe Gln Lys 
                245                 


<210>  32
<211>  202
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IFNgR1 intracellular AA SEQUENCE

<400>  32

Trp Tyr Thr Lys Asn Asn Ser Phe Lys Arg Lys Ser Ile Met Leu Pro 
1               5                   10                  15      


Lys Ser Leu Leu Ser Val Val Lys Ser Ala Thr Leu Glu Thr Lys Pro 
            20                  25                  30          


Glu Ser Lys Tyr Ser Leu Val Thr Pro His Gln Pro Ala Val Leu Glu 
        35                  40                  45              


Ser Glu Thr Val Ile Cys Glu Glu Pro Leu Ser Thr Val Thr Ala Pro 
    50                  55                  60                  


Asp Ser Pro Glu Ala Ala Glu Gln Glu Glu Leu Ser Lys Glu Thr Lys 
65                  70                  75                  80  


Ala Leu Glu Ala Gly Gly Ser Thr Ser Ala Met Thr Pro Asp Ser Pro 
                85                  90                  95      


Pro Thr Pro Thr Gln Arg Arg Ser Phe Ser Leu Leu Ser Ser Asn Gln 
            100                 105                 110         


Ser Gly Pro Cys Ser Leu Thr Ala Tyr His Ser Arg Asn Gly Ser Asp 
        115                 120                 125             


Ser Gly Leu Val Gly Ser Gly Ser Ser Ile Ser Asp Leu Glu Ser Leu 
    130                 135                 140                 


Pro Asn Asn Asn Ser Glu Thr Lys Met Ala Glu His Asp Pro Pro Pro 
145                 150                 155                 160 


Val Arg Lys Ala Pro Met Ala Ser Gly Tyr Asp Lys Pro His Met Leu 
                165                 170                 175     


Val Asp Val Leu Val Asp Val Gly Gly Lys Glu Ser Leu Met Gly Tyr 
            180                 185                 190         


Arg Leu Thr Gly Glu Ala Gln Glu Leu Ser 
        195                 200         


<210>  33
<211>  67
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IFNgR2 intracellular AA SEQUENCE

<400>  33

Leu Lys Tyr Gln Ser Arg Val Lys Tyr Trp Phe Gln Ala Pro Pro Asn 
1               5                   10                  15      


Ile Pro Glu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Asp Gln Phe Ile 
            20                  25                  30          


Leu Glu Val Leu Asp Lys Asp Gly Ser Pro Lys Glu Asp Ser Trp Asp 
        35                  40                  45              


Ser Val Ser Ile Ile Ser Ser Pro Glu Lys Glu Arg Asp Asp Val Leu 
    50                  55                  60                  


Gln Thr Pro 
65          


<210>  34
<211>  271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-2Rb intracellular AA SEQUENCE

<400>  34

Lys Cys Arg Tyr Leu Gly Pro Trp Leu Lys Thr Val Leu Lys Cys His 
1               5                   10                  15      


Ile Pro Asp Pro Ser Glu Phe Phe Ser Gln Leu Ser Ser Gln His Gly 
            20                  25                  30          


Gly Asp Leu Gln Lys Trp Leu Ser Ser Pro Val Pro Leu Ser Phe Phe 
        35                  40                  45              


Ser Pro Ser Gly Pro Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Asp 
    50                  55                  60                  


Gly Asp Ser Lys Ala Val Gln Leu Leu Leu Leu Gln Lys Asp Ser Ala 
65                  70                  75                  80  


Pro Leu Pro Ser Pro Ser Gly His Ser Gln Ala Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asn Ala Leu Glu Ile Glu Ser 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Cys Val Glu Glu Glu Val Glu 
        115                 120                 125             


Glu Asp Gly Ser Arg Leu Pro Glu Gly Ser Pro His Pro Pro Leu Leu 
    130                 135                 140                 


Pro Leu Ala Gly Glu Gln Asp Asp Tyr Cys Ala Phe Pro Pro Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Ser Thr Pro Asn Thr Ala Tyr 
                165                 170                 175     


Gly Gly Ser Arg Ala Pro Glu Glu Arg Ser Pro Leu Ser Leu His Glu 
            180                 185                 190         


Gly Leu Pro Ser Leu Ala Ser Arg Asp Leu Met Gly Leu Gln Arg Pro 
        195                 200                 205             


Leu Glu Arg Met Pro Glu Gly Asp Gly Glu Gly Leu Ser Ala Asn Ser 
    210                 215                 220                 


Ser Gly Glu Gln Ala Ser Val Pro Glu Gly Asn Leu His Gly Gln Asp 
225                 230                 235                 240 


Gln Asp Arg Gly Gln Gly Pro Ile Leu Thr Leu Asn Thr Asp Ala Tyr 
                245                 250                 255     


Leu Ser Leu Gln Glu Leu Gln Ala Gln Asp Ser Val His Leu Ile 
            260                 265                 270     


<210>  35
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-1R1 intracellular AA sequence

<400>  35

Lys Val Phe Lys Val Asp Ile Val Leu Trp Tyr Arg Asp Ser Cys Ser 
1               5                   10                  15      


Gly Phe Leu Pro Ser Lys Ala Ser Asp Gly Lys Thr Tyr Asp Ala Tyr 
            20                  25                  30          


Ile Leu Tyr Pro Lys Thr Leu Gly Glu Gly Ser Phe Ser Asp Leu Asp 
        35                  40                  45              


Thr Phe Val Phe Lys Leu Leu Pro Glu Val Leu Glu Gly Gln Phe Gly 
    50                  55                  60                  


Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val Gly Glu Asp Thr 
65                  70                  75                  80  


Ile Glu Val Thr Asn Glu Asn Val Lys Lys Ser Arg Arg Leu Ile Ile 
                85                  90                  95      


Ile Leu Val Arg Asp Met Gly Gly Phe Ser Trp Leu Gly Gln Ser Ser 
            100                 105                 110         


Glu Glu Gln Ile Ala Ile Tyr Asn Ala Leu Ile Gln Glu Gly Ile Lys 
        115                 120                 125             


Ile Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr Glu Lys Met Pro 
    130                 135                 140                 


Asp Ser Ile Gln Phe Ile Lys Gln Lys His Gly Val Ile Cys Trp Ser 
145                 150                 155                 160 


Gly Asp Phe Gln Glu Arg Pro Gln Ser Ala Lys Thr Arg Phe Trp Lys 
                165                 170                 175     


Asn Leu Arg Tyr Gln Met Pro Ala Gln Arg Arg Ser Pro Leu Ser Lys 
            180                 185                 190         


His Arg Leu Leu Thr Leu Asp Pro Val Arg Asp Thr Lys Glu Lys Leu 
        195                 200                 205             


Pro Ala Ala Thr His Leu Pro Leu Gly 
    210                 215         


<210>  36
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL-1AcP intracellular AA sequence

<400>  36

Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu Asp Gly Lys Glu 
1               5                   10                  15      


Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Val Glu Glu Glu Glu Phe 
            20                  25                  30          


Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu Phe Gly Tyr Lys 
        35                  40                  45              


Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly Ile Val Thr Asp 
    50                  55                  60                  


Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu Leu Val Val Leu 
65                  70                  75                  80  


Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu Leu Glu Leu Lys 
                85                  90                  95      


Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile Asn Val Ile Leu 
            100                 105                 110         


Val Gln Tyr Lys Ala Val Lys Asp Met Lys Val Lys Glu Leu Lys Arg 
        115                 120                 125             


Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly Glu Lys Ser Lys 
    130                 135                 140                 


Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val Ala Met Pro Val 
145                 150                 155                 160 


Lys Lys Ser Pro Arg Trp Ser Ser Asn Asp Lys Gln Gly Leu Ser Tyr 
                165                 170                 175     


Ser Ser Leu Lys Asn Val 
            180         


<210>  37
<211>  526
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv-alpha-gamma-2A-gamma construct aa seequence (human origin)

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
        35                  40                  45              


Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr 
65                  70                  75                  80  


Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys 
                85                  90                  95      


Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Leu Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser 
                165                 170                 175     


Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr 
            180                 185                 190         


Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser 
        195                 200                 205             


Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Glu Leu Ala Ser Val Thr Ser Pro Leu Leu Glu Gly 
            260                 265                 270         


Asn Leu Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro 
        275                 280                 285             


Gly Leu Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg 
    290                 295                 300                 


Gly Arg Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val 
                325                 330                 335     


Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu 
            340                 345                 350         


Pro Thr Pro Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile 
        355                 360                 365             


Met Phe Leu Val Asn Thr Val Leu Trp Val Thr Ile Arg Leu Lys Ile 
    370                 375                 380                 


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
385                 390                 395                 400 


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
                405                 410                 415     


His Glu Lys Pro Pro Gln Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
            420                 425                 430         


Asp Val Glu Glu Asn Pro Gly Pro Met Ile Pro Ala Val Val Leu Leu 
        435                 440                 445             


Leu Leu Leu Leu Val Glu Gln Ala Ala Ala Leu Gly Glu Pro Gln Leu 
    450                 455                 460                 


Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu Thr 
465                 470                 475                 480 


Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr 
                485                 490                 495     


Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn 
            500                 505                 510         


Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        515                 520                 525     


<210>  38
<211>  1578
<212>  DNA
<213>  Artificial sequence

<220>
<223>  scFv-alpha-gamma-2A-gamma construct NA sequqence (human origin)

<400>  38
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaagtac aacttaaaca gagcggtcct ggtctggtgc aaccctccca aagcctttca      120

atcacgtgta ccgtttccgg gttttcactt acgaattacg gcgtccattg ggtgcggcaa      180

agtccaggca aaggtctgga gtggcttggc gtaatctggt caggaggtaa tacggactac      240

aacacacctt ttactagcag acttagcatc aacaaggata acagtaagag tcaggtcttc      300

ttcaagatga atagtttgca atccaatgat acagctatct actactgcgc cagagctttg      360

acctactacg attatgagtt tgcatattgg ggtcaaggaa ctctggtaac agtaagcgcc      420

gcttcaggtg gaggtggttc tgggggtggg ggctcaggtg ggggaggtag cattcttctc      480

acccagtcac ccgttatact ttccgtatct ccgggagaaa gggtctcttt cagttgtcgc      540

gcgagtcaaa gcataggcac taatatccac tggtaccaac aaagaacaaa cggttcaccc      600

agactgttga tcaaatatgc gtcagagagt attagcggga tccctagcag attttccggg      660

agcggaagcg gtactgattt tacactgagc attaatagcg ttgaaagtga ggatattgcg      720

gactactact gccaacaaaa caataactgg cctacaactt tcggtgcagg tacgaaattg      780

gagctcgcat ctgtgacatc cccactcctg gaggggaatc tggtcaccct gagctgtgaa      840

acaaagttgc tcttgcagag gcctggtttg cagctttact tctccttcta catgggcagc      900

aagaccctgc gaggcaggaa cacatcctct gaataccaaa tactaactgc tagaagagaa      960

gactctgggt tatactggtg cgaggctgcc acagaggatg gaaatgtcct taagcgcagc     1020

cctgagttgg agcttcaagt gcttggcctc cagttaccaa ctcctgtctg gtttcatgtc     1080

cttttctatc tggcagtggg aataatgttt ttagtgaaca ctgttctctg ggtgacaata     1140

cgactgaaga tccaagtgcg aaaggcagct ataaccagct atgagaaatc agatggtgtt     1200

tacacgggcc tgagcaccag gaaccaggag acttacgaga ctctgaagca tgagaaacca     1260

ccacaggagg gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa tcctggccca     1320

atgattccag cagtggtctt gctcttactc cttttggttg aacaagcagc ggccctggga     1380

gagcctcagc tctgctatat cctggatgcc atcctgtttc tgtatggaat tgtcctcacc     1440

ctcctctact gtcgactgaa gatccaagtg cgaaaggcag ctataaccag ctatgagaaa     1500

tcagatggtg tttacacggg cctgagcacc aggaaccagg agacttacga gactctgaag     1560

catgagaaac caccacag                                                   1578


<210>  39
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
1               5                   10                  15      


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210>  40
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  40
cgactgaaga tccaagtgcg aaaggcagct ataaccagct atgagaaatc agatggtgtt       60

tacacgggcc tgagcaccag gaaccaggag acttacgaga ctctgaagca tgagaaacca      120

ccacag                                                                 126


<210>  41
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-EFGR variable heavy chain aa sequence

<400>  41

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser 
        115                 120     


<210>  42
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-EFGR variable light chain aa sequence

<400>  42

Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu 
1               5                   10                  15      


Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys 
        35                  40                  45              


Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu 
65                  70                  75                  80  


Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105 


<210>  43
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti EGFR scFv aa sequence

<400>  43

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ile Leu Leu Thr Gln Ser Pro Val 
    130                 135                 140                 


Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn 
                165                 170                 175     


Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu 
    


<210>  44
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val 
1               5                   10                  15      


Ser Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His 
            20                  25                  30          


Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr 
        35                  40                  45              


Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp 
    50                  55                  60                  


Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro 
65                  70                  75                  80  


Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser 
                85                  90                  95      


Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp 
            100                 105                 110         


Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala 
        115                 120                 125             


Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn 
    130                 135                 140                 


Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala 
                165                 170                 175     


Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu 
            180                 185                 190         


Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser 
225                 230                 235                 240 


Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr 
            260                 265                 270         


Pro Val Trp Phe His 
        275         


<210>  45
<211>  180
<212>  PRT
<213>  mus musculus

<400>  45

Glu Val Val Asn Ala Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp 
1               5                   10                  15      


Val Ser Ile Phe Gln Lys Glu Asn Val Thr Leu Trp Cys Glu Gly Pro 
            20                  25                  30          


His Leu Pro Gly Asp Ser Ser Thr Gln Trp Phe Ile Asn Gly Thr Ala 
        35                  40                  45              


Val Gln Ile Ser Thr Pro Ser Tyr Ser Ile Pro Glu Ala Ser Phe Gln 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Ile Gly Ser Ser Met Pro Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Gln Ile His Asn Asp Trp Leu Leu Leu Gln Ala Ser 
                85                  90                  95      


Arg Arg Val Leu Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Gly 
            100                 105                 110         


Trp Lys Asn Lys Leu Val Tyr Asn Val Val Phe Tyr Arg Asn Gly Lys 
        115                 120                 125             


Ser Phe Gln Phe Ser Ser Asp Ser Glu Val Ala Ile Leu Lys Thr Asn 
    130                 135                 140                 


Leu Ser His Ser Gly Ile Tyr His Cys Ser Gly Thr Gly Arg His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Val Ser Ile Thr Val Lys Glu Leu Phe Thr Thr 
                165                 170                 175     


Pro Val Leu Arg 
            180 


<210>  46
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val 
1               5                   10                  15      


Ser Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His 
            20                  25                  30          


Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr 
        35                  40                  45              


Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp 
    50                  55                  60                  


Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro 
65                  70                  75                  80  


Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser 
                85                  90                  95      


Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp 
            100                 105                 110         


Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala 
        115                 120                 125             


Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn 
    130                 135                 140                 


Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala 
                165                 170                 175     


Pro Val Leu Asn 
            180 


<210>  47
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  47

Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn Thr Val 
1               5                   10                  15      


Leu Trp Val Thr Ile 
            20      


<210>  48
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val 
1               5                   10                  15      


Ser Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His 
            20                  25                  30          


Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr 
        35                  40                  45              


Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp 
    50                  55                  60                  


Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro 
65                  70                  75                  80  


Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser 
                85                  90                  95      


Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp 
            100                 105                 110         


Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala 
        115                 120                 125             


Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn 
    130                 135                 140                 


Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala 
                165                 170                 175     


Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu 
            180                 185                 190         


Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser 
225                 230                 235                 240 


Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr 
            260                 265                 270         


Pro Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe 
        275                 280                 285             


Leu Val Asn Thr Val Leu Trp Val Thr Ile 
    290                 295             


<210>  49
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val 
1               5                   10                  15      


Ser Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His 
            20                  25                  30          


Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr 
        35                  40                  45              


Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp 
    50                  55                  60                  


Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro 
65                  70                  75                  80  


Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser 
                85                  90                  95      


Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp 
            100                 105                 110         


Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala 
        115                 120                 125             


Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn 
    130                 135                 140                 


Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala 
                165                 170                 175     


Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu 
            180                 185                 190         


Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser 
225                 230                 235                 240 


Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr 
            260                 265                 270         


Pro Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe 
        275                 280                 285             


Leu Val Asn Thr Val Leu Trp Val Thr Ile Arg Leu Lys Ile Gln Val 
    290                 295                 300                 


Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr 
305                 310                 315                 320 


Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu 
                325                 330                 335     


Lys Pro Pro Gln 
            340 


<210>  50
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  50

Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys 
            20      


<210>  51
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  51

Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile 
            20                  25                  30          


Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg 
        35                  40                  45              


Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
    50                  55                  60              


<210>  52
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ile Leu Leu Thr Gln Ser Pro Val 
    130                 135                 140                 


Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn 
                165                 170                 175     


Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val Thr Leu 
                245                 250                 255     


Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu Tyr 
            260                 265                 270         


Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn Thr Ser 
        275                 280                 285             


Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly Leu Tyr 
    290                 295                 300                 


Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg Ser Pro 
305                 310                 315                 320 


Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro Val Trp 
                325                 330                 335     


Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn 
            340                 345                 350         


Thr Val Leu Trp Val Thr Ile Arg Leu Lys Ile Gln Val Arg Lys Ala 
        355                 360                 365             


Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser 
    370                 375                 380                 


Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro 
385                 390                 395                 400 


Gln 
    


<210>  53
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat sequence  1-4 times

<220>
<221>  REPEAT
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (16)..(20)
<223>  may be absent

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence

<400>  54

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  55
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence

<400>  55

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  56
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence

<400>  56

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  57
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat 1-3 times

<220>
<221>  REPEAT
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (11)..(15)
<223>  may be absent

<400>  57

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  58
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence

<400>  58

Pro Ala Pro Ala Pro 
1               5   


<210>  59
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker amino acid sequence

<400>  59

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  60
<211>  93
<212>  PRT
<213>  mus musculus

<400>  60

Ala Ser Val Ser Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn 
1               5                   10                  15      


Cys Glu Thr Asn Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe 
            20                  25                  30          


Ser Phe Tyr Val Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser 
        35                  40                  45              


Glu Tyr His Ile Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp 
    50                  55                  60                  


Cys Glu Val Ala Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu 
65                  70                  75                  80  


Leu Glu Leu Gln Val Leu Gly Pro Gln Ser Ser Ala Pro 
                85                  90              


<210>  61
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val Thr Leu Ser 
1               5                   10                  15      


Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu Tyr Phe 
            20                  25                  30          


Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn Thr Ser Ser 
        35                  40                  45              


Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly Leu Tyr Trp 
    50                  55                  60                  


Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg Ser Pro Glu 
65                  70                  75                  80  


Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro Val Trp Phe 
                85                  90                  95      


His 
    


<210>  62
<211>  1395
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alpha-2A-gamma construct NA sequqence (HUMAN origin)

<400>  62
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaagtgg acaccacaaa ggcagtgatc actttgcagc ctccatgggt cagcgtgttc      120

caagaggaaa ccgtaacctt gcattgtgag gtgctccatc tgcctgggag cagctctaca      180

cagtggtttc tcaatggcac agccactcag acctcgaccc ccagctacag aatcacctct      240

gccagtgtca atgacagtgg tgaatacagg tgccagagag gtctctcagg gcgaagtgac      300

cccatacagc tggaaatcca cagaggctgg ctactactgc aggtctccag cagagtcttc      360

acggaaggag aacctctggc cttgaggtgt catgcgtgga aggataagct ggtgtacaat      420

gtgctttact atcgaaatgg caaagccttt aagtttttcc actggaactc taacctcacc      480

attctgaaaa ccaacataag tcacaatggc acctaccatt gctcaggcat gggaaagcat      540

cgctacacat cagcaggaat atctgtcact gtgaaagagc tatttccagc tccagtgctg      600

aatgcatctg tgacatcccc actcctggag gggaatctgg tcaccctgag ctgtgaaaca      660

aagttgctct tgcagaggcc tggtttgcag ctttacttct ccttctacat gggcagcaag      720

accctgcgag gcaggaacac atcctctgaa taccaaatac taactgctag aagagaagac      780

tctgggttat actggtgcga ggctgccaca gaggatggaa atgtccttaa gcgcagccct      840

gagttggagc ttcaagtgct tggcctccag ttaccaactc ctgtctggtt tcatgtcctt      900

ttctatctgg cagtgggaat aatgttttta gtgaacactg ttctctgggt gacaatacga      960

ctgaagatcc aagtgcgaaa ggcagctata accagctatg agaaatcaga tggtgtttac     1020

acgggcctga gcaccaggaa ccaggagact tacgagactc tgaagcatga gaaaccacca     1080

caggagggca gaggaagtct gctaacatgc ggtgacgtcg aggagaatcc tggcccaatg     1140

attccagcag tggtcttgct cttactcctt ttggttgaac aagcagcggc cctgggagag     1200

cctcagctct gctatatcct ggatgccatc ctgtttctgt atggaattgt cctcaccctc     1260

ctctactgtc gactgaagat ccaagtgcga aaggcagcta taaccagcta tgagaaatca     1320

gatggtgttt acacgggcct gagcaccagg aaccaggaga cttacgagac tctgaagcat     1380

gagaaaccac cacag                                                      1395


<210>  63
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alpha-gamma 2A-gamma construct aa seequence (HUMAN origin)

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu 
            20                  25                  30          


Gln Pro Pro Trp Val Ser Val Phe Gln Glu Glu Thr Val Thr Leu His 
        35                  40                  45              


Cys Glu Val Leu His Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu 
    50                  55                  60                  


Asn Gly Thr Ala Thr Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser 
65                  70                  75                  80  


Ala Ser Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser 
                85                  90                  95      


Gly Arg Ser Asp Pro Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu 
            100                 105                 110         


Leu Gln Val Ser Ser Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu 
        115                 120                 125             


Arg Cys His Ala Trp Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr 
    130                 135                 140                 


Arg Asn Gly Lys Ala Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr 
145                 150                 155                 160 


Ile Leu Lys Thr Asn Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly 
                165                 170                 175     


Met Gly Lys His Arg Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys 
            180                 185                 190         


Glu Leu Phe Pro Ala Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu 
        195                 200                 205             


Leu Glu Gly Asn Leu Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu 
    210                 215                 220                 


Gln Arg Pro Gly Leu Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys 
225                 230                 235                 240 


Thr Leu Arg Gly Arg Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala 
                245                 250                 255     


Arg Arg Glu Asp Ser Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp 
            260                 265                 270         


Gly Asn Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly 
        275                 280                 285             


Leu Gln Leu Pro Thr Pro Val Trp Phe His Val Leu Phe Tyr Leu Ala 
    290                 295                 300                 


Val Gly Ile Met Phe Leu Val Asn Thr Val Leu Trp Val Thr Ile Arg 
305                 310                 315                 320 


Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
                325                 330                 335     


Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
            340                 345                 350         


Thr Leu Lys His Glu Lys Pro Pro Gln Glu Gly Arg Gly Ser Leu Leu 
        355                 360                 365             


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile Pro Ala Val 
    370                 375                 380                 


Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala Ala Ala Leu Gly Glu 
385                 390                 395                 400 


Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile 
                405                 410                 415     


Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys Ala 
            420                 425                 430         


Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser 
        435                 440                 445             


Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro 
    450                 455                 460                 


Gln 
465 


<210>  64
<211>  277
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extracellular domain of CD64 (D1+D2+D3) AA sequence (HUMAN)

<400>  64

Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val 
1               5                   10                  15      


Ser Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His 
            20                  25                  30          


Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr 
        35                  40                  45              


Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp 
    50                  55                  60                  


Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro 
65                  70                  75                  80  


Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser 
                85                  90                  95      


Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp 
            100                 105                 110         


Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala 
        115                 120                 125             


Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn 
    130                 135                 140                 


Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala 
                165                 170                 175     


Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu 
            180                 185                 190         


Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser 
225                 230                 235                 240 


Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr 
            260                 265                 270         


Pro Val Trp Phe His 
        275         


<210>  65
<211>  831
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Extracellular domain of CD64 (D1+D2+D3) NA sequence (HUMAN)

<400>  65
caagtggaca ccacaaaggc agtgatcact ttgcagcctc catgggtcag cgtgttccaa       60

gaggaaaccg taaccttgca ttgtgaggtg ctccatctgc ctgggagcag ctctacacag      120

tggtttctca atggcacagc cactcagacc tcgaccccca gctacagaat cacctctgcc      180

agtgtcaatg acagtggtga atacaggtgc cagagaggtc tctcagggcg aagtgacccc      240

atacagctgg aaatccacag aggctggcta ctactgcagg tctccagcag agtcttcacg      300

gaaggagaac ctctggcctt gaggtgtcat gcgtggaagg ataagctggt gtacaatgtg      360

ctttactatc gaaatggcaa agcctttaag tttttccact ggaactctaa cctcaccatt      420

ctgaaaacca acataagtca caatggcacc taccattgct caggcatggg aaagcatcgc      480

tacacatcag caggaatatc tgtcactgtg aaagagctat ttccagctcc agtgctgaat      540

gcatctgtga catccccact cctggagggg aatctggtca ccctgagctg tgaaacaaag      600

ttgctcttgc agaggcctgg tttgcagctt tacttctcct tctacatggg cagcaagacc      660

ctgcgaggca ggaacacatc ctctgaatac caaatactaa ctgctagaag agaagactct      720

gggttatact ggtgcgaggc tgccacagag gatggaaatg tccttaagcg cagccctgag      780

ttggagcttc aagtgcttgg cctccagtta ccaactcctg tctggtttca t               831


<210>  66
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Transmembrane domain of CD64 NA sequence (HUMAN)

<400>  66
gtccttttct atctggcagt gggaataatg tttttagtga acactgttct ctgggtgaca       60

ata                                                                     63


<210>  67
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcR gamma chain TM nA SEQUENCE (HUMAN)

<400>  67
ctctgctata tcctggatgc catcctgttt ctgtatggaa ttgtcctcac cctcctctac       60

tgt                                                                     63


<210>  68
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcR gamma  chain EC NA SEQUENCE (HUMAN)

<400>  68
ctgggagagc ctcag                                                        15


<210>  69
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcR gamma chain EC AA SEQUENCE (HUMAN)

<400>  69

Leu Gly Glu Pro Gln 
1               5   


<210>  70
<211>  204
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FcR gamma chain EC+TM+IC NA SEQUENCE (HUMAN)

<400>  70
ctgggagagc ctcagctctg ctatatcctg gatgccatcc tgtttctgta tggaattgtc       60

ctcaccctcc tctactgtcg actgaagatc caagtgcgaa aggcagctat aaccagctat      120

gagaaatcag atggtgttta cacgggcctg agcaccagga accaggagac ttacgagact      180

ctgaagcatg agaaaccacc acag                                             204


<210>  71
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FcR gamma chain EC+TM+IC AA SEQUENCE (HUMAN)

<400>  71

Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu 
1               5                   10                  15      


Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val 
            20                  25                  30          


Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr 
        35                  40                  45              


Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu 
    50                  55                  60                  


Lys Pro Pro Gln 
65              


<210>  72
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD8A signal peptide NA

<400>  72
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  73
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD8A signal peptide AA

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  74
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SIGNAL SEQUENCE NA

<400>  74
atgattccag cagtggtctt gctcttactc cttttggttg aacaagcagc ggcc             54


<210>  75
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SIGNAL SEQUENCE AA

<400>  75

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala 
        


<210>  76
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  T2A peptide NA

<400>  76
gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg ccca             54


<210>  77
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T2A peptide AA

<400>  77

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


