                         SEQUENCE LISTING

<110>  Technion Research and Development Foundation Ltd.
 
<120>  MODIFIED CXCL10 FOR IMMUNOTHERAPY OF CANCER DISEASES

<130>  TECH/017-PCT

<150>  63/041,936
<151>  2020-06-21

<150>  63/150,622
<151>  2021-02-18

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Xaa Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys 
                85                  90                  95      


Arg Ser Pro 
            


<210>  2
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  2

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Gln Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys 
                85                  90                  95      


Arg Ser Pro 
            


<210>  3
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Asn Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys 
                85                  90                  95      


Arg Ser Pro 
            


<210>  4
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Pro Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys 
                85                  90                  95      


Arg Ser Pro 
            


<210>  5
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  6
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6
ggggsggggs ggggs                                                        15


<210>  7
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7
ggggs                                                                    5


<210>  8
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  9
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggagtacctc tctctagaac tgtacgctgt acctgcatca gcattagtaa tcaacctgtt      120

aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg tccacgtgtt      180

gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc agaatcgaag      240

gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc tcct            294


<210>  10
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggacaagtac ctctctctag aactgtacgc tgtacctgca tcagcattag taatcaacct      120

gttaatccaa ggtctttaga aaaacttgaa attattcctg caagccaatt ttgtccacgt      180

gttgagatca ttgctacaat gaaaaagaag ggtgagaaga gatgtctgaa tccagaatcg      240

aaggccatca agaatttact gaaagcagtt agcaaggaaa ggtctaaaag atctcct         297


<210>  11
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggaaacgtac ctctctctag aactgtacgc tgtacctgca tcagcattag taatcaacct      120

gttaatccaa ggtctttaga aaaacttgaa attattcctg caagccaatt ttgtccacgt      180

gttgagatca ttgctacaat gaaaaagaag ggtgagaaga gatgtctgaa tccagaatcg      240

aaggccatca agaatttact gaaagcagtt agcaaggaaa ggtctaaaag atctcct         297


<210>  12
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggacccgtac ctctctctag aactgtacgc tgtacctgca tcagcattag taatcaacct      120

gttaatccaa ggtctttaga aaaacttgaa attattcctg caagccaatt ttgtccacgt      180

gttgagatca ttgctacaat gaaaaagaag ggtgagaaga gatgtctgaa tccagaatcg      240

aaggccatca agaatttact gaaagcagtt agcaaggaaa ggtctaaaag atctcct         297


<210>  13
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtccccg ggtaaa                                696


<210>  14
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Lys Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  15
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  15

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser His Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  16
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  16
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggagtacctc tctctcacac tgtacgctgt acctgcatca gcattagtaa tcaacctgtt      120

aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg tccacgtgtt      180

gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc agaatcgaag      240

gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc tcct            294


<210>  17
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggagtacctc tctctaagac tgtacgctgt acctgcatca gcattagtaa tcaacctgtt      120

aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg tccacgtgtt      180

gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc agaatcgaag      240

gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc tcct            294


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  18

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser 
    


<210>  19
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  19
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggagtacctc tctctagaac tgtacgctgt acctgcatca gcattagtaa tcaacctgtt      120

aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg tccacgtgtt      180

gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc agaatcgaag      240

gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc tcctggcgga      300

ggtggctctg gcggtggcgg atcgggcgga ggtggctct                             339


<210>  20
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  20

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Ile Pro Leu Ala Arg Thr Val Arg Cys Asn Cys 
            20                  25                  30          


Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys Arg 
                85                  90                  95      


Ala Pro 
        


<210>  21
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  21

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  22
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  22

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Ile Pro Leu Ala His Thr Val Arg Cys Asn Cys 
            20                  25                  30          


Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys Arg 
                85                  90                  95      


Ala Pro 
        


<210>  23
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  23

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Ile Pro Leu Ala Lys Thr Val Arg Cys Asn Cys 
            20                  25                  30          


Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys Arg 
                85                  90                  95      


Ala Pro 
        


<210>  24
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  24

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Gln Ile Pro Leu Ala Arg Thr Val Arg Cys Asn 
            20                  25                  30          


Cys Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys 
                85                  90                  95      


Arg Ala Pro 
            


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  25

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Ile Pro Leu Ala Arg Thr Val Arg Cys Asn Cys 
            20                  25                  30          


Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys Arg 
                85                  90                  95      


Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser 
    


<210>  26
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  26
atgaacccaa gtgctgccgt cattttctgc ctcatcctgc tgggtctgag tgggactcaa       60

gggatccctc tcgcaaggac ggtccgctgc aactgcatcc atatcgatga cgggccagtg      120

agaatgaggg ccatagggaa gcttgaaatc atccctgcga gcctatcctg cccacgtgtt      180

gagatcattg ccacgatgaa aaagaatgat gagcagagat gtctgaatcc ggaatctaag      240

accatcaaga atttaatgaa agcgtttagc caaaaaaggt ctaaaagggc tcctggcgga      300

ggtggctctg gcggtggcgg atcgggcgga ggtggctct                             339


<210>  27
<211>  298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  27
atgaacccaa gtgctgccgt cattttctgc ctcatcctgc tgggtctgag tgggactcaa       60

gggcaaatcc ctctcgcaag gacggtccgc tgcaactgca tccatatcga tgacgggcca      120

gtgagaatga gggccatagg gaagcttgaa atcatccctg cgagcctatc ctgcccacgt      180

gttgagatca ttgccacgat gaaaaagaat gatgagcaga gatgtctgaa tccggaatct      240

aagaccatca agaatttaat gaaagcgttt agccaaaaaa ggtctaaaag ggctcctc        298


<210>  28
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  28

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Gln Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys 
                85                  90                  95      


Arg Ser Pro Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
            100                 105                 110         


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
145                 150                 155                 160 


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys 
            180                 185                 190         


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
    210                 215                 220                 


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
225                 230                 235                 240 


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
                245                 250                 255     


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
            260                 265                 270         


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
        275                 280                 285             


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
    290                 295                 300                 


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
305                 310                 315                 320 


Ser His Ser Pro Gly Lys 
                325     


<210>  29
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  29
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggacaagtac ctctctctag aactgtacgc tgtacctgca tcagcattag taatcaacct      120

gttaatccaa ggtctttaga aaaacttgaa attattcctg caagccaatt ttgtccacgt      180

gttgagatca ttgctacaat gaaaaagaag ggtgagaaga gatgtctgaa tccagaatcg      240

aaggccatca agaatttact gaaagcagtt agcaaggaaa ggtctaaaag atctcctgtg      300

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      360

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      420

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      480

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      540

tcagtcagtg aacttcccat catgcaccag gactgcctca atggcaagga gttcaaatgc      600

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc      660

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat      720

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg      780

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat      840

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat      900

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc      960

tcccactctc ctggtaaa                                                    978


<210>  30
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  30

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Asn Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys 
                85                  90                  95      


Arg Ser Pro Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
            100                 105                 110         


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
145                 150                 155                 160 


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys 
            180                 185                 190         


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
    210                 215                 220                 


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
225                 230                 235                 240 


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
                245                 250                 255     


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
            260                 265                 270         


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
        275                 280                 285             


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
    290                 295                 300                 


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
305                 310                 315                 320 


Ser His Ser Pro Gly Lys 
                325     


<210>  31
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  31
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggaaatgtac ctctctctag aactgtacgc tgtacctgca tcagcattag taatcaacct      120

gttaatccaa ggtctttaga aaaacttgaa attattcctg caagccaatt ttgtccacgt      180

gttgagatca ttgctacaat gaaaaagaag ggtgagaaga gatgtctgaa tccagaatcg      240

aaggccatca agaatttact gaaagcagtt agcaaggaaa ggtctaaaag atctcctgtg      300

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      360

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      420

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      480

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      540

tcagtcagtg aacttcccat catgcaccag gactgcctca atggcaagga gttcaaatgc      600

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc      660

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat      720

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg      780

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat      840

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat      900

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc      960

tcccactctc ctggtaaa                                                    978


<210>  32
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  32

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
        115                 120                 125             


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
    130                 135                 140                 


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
145                 150                 155                 160 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
                165                 170                 175     


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            180                 185                 190         


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys Leu Asn 
        195                 200                 205             


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
    210                 215                 220                 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
225                 230                 235                 240 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
                245                 250                 255     


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
            260                 265                 270         


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
        275                 280                 285             


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
    290                 295                 300                 


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
305                 310                 315                 320 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
                325                 330                 335     


Ser Pro Gly Lys 
            340 


<210>  33
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  33
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggagtacctc tctctagaac tgtacgctgt acctgcatca gcattagtaa tcaacctgtt      120

aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg tccacgtgtt      180

gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc agaatcgaag      240

gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc tcctggcgga      300

ggtggctctg gcggtggcgg atcgggcgga ggtggctctg tgcccaggga ttgtggttgt      360

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      420

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      480

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      540

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      600

atcatgcacc aggactgcct caatggcaag gagttcaaat gcagggtcaa cagtgcagct      660

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag      720

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc      780

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca      840

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac      900

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg      960

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1020


<210>  34
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  34

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Gln Ile Pro Leu Ala Arg Thr Val Arg Cys Asn 
            20                  25                  30          


Cys Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys 
                85                  90                  95      


Arg Ala Pro Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
            100                 105                 110         


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
145                 150                 155                 160 


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys 
            180                 185                 190         


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
    210                 215                 220                 


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
225                 230                 235                 240 


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
                245                 250                 255     


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
            260                 265                 270         


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
        275                 280                 285             


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
    290                 295                 300                 


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
305                 310                 315                 320 


Ser His Ser Pro Gly Lys 
                325     


<210>  35
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  35
atgaacccaa gtgctgccgt cattttctgc ctcatcctgc tgggtctgag tgggactcaa       60

gggcaaatcc ctctcgcaag gacggtccgc tgcaactgca tccatatcga tgacgggcca      120

gtgagaatga gggccatagg gaagcttgaa atcatccctg cgagcctatc ctgcccacgt      180

gttgagatca ttgccacgat gaaaaagaat gatgagcaga gatgtctgaa tccggaatct      240

aagaccatca agaatttaat gaaagcgttt agccaaaaaa ggtctaaaag ggctcctgtg      300

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      360

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      420

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      480

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      540

tcagtcagtg aacttcccat catgcaccag gactgcctca atggcaagga gttcaaatgc      600

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc      660

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat      720

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg      780

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat      840

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat      900

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc      960

tcccactctc ctggtaaa                                                    978


<210>  36
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Asn Ile Pro Leu Ala Arg Thr Val Arg Cys Asn 
            20                  25                  30          


Cys Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys 
                85                  90                  95      


Arg Ala Pro Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
            100                 105                 110         


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
145                 150                 155                 160 


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys 
            180                 185                 190         


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
    210                 215                 220                 


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
225                 230                 235                 240 


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
                245                 250                 255     


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
            260                 265                 270         


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
        275                 280                 285             


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
    290                 295                 300                 


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
305                 310                 315                 320 


Ser His Ser Pro Gly Lys 
                325     


<210>  37
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  37
atgaacccaa gtgctgccgt cattttctgc ctcatcctgc tgggtctgag tgggactcaa       60

gggaatatcc ctctcgcaag gacggtccgc tgcaactgca tccatatcga tgacgggcca      120

gtgagaatga gggccatagg gaagcttgaa atcatccctg cgagcctatc ctgcccacgt      180

gttgagatca ttgccacgat gaaaaagaat gatgagcaga gatgtctgaa tccggaatct      240

aagaccatca agaatttaat gaaagcgttt agccaaaaaa ggtctaaaag ggctcctgtg      300

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      360

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      420

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      480

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      540

tcagtcagtg aacttcccat catgcaccag gactgcctca atggcaagga gttcaaatgc      600

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc      660

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat      720

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg      780

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat      840

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat      900

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc      960

tcccactctc ctggtaaa                                                    978


<210>  38
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  38

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Ile Pro Leu Ala Arg Thr Val Arg Cys Asn Cys 
            20                  25                  30          


Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys Arg 
                85                  90                  95      


Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
        115                 120                 125             


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
    130                 135                 140                 


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
145                 150                 155                 160 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
                165                 170                 175     


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            180                 185                 190         


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys Leu Asn 
        195                 200                 205             


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
    210                 215                 220                 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
225                 230                 235                 240 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
                245                 250                 255     


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
            260                 265                 270         


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
        275                 280                 285             


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
    290                 295                 300                 


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
305                 310                 315                 320 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
                325                 330                 335     


Ser Pro Gly Lys 
            340 


<210>  39
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  39
atgaacccaa gtgctgccgt cattttctgc ctcatcctgc tgggtctgag tgggactcaa       60

gggatccctc tcgcaaggac ggtccgctgc aactgcatcc atatcgatga cgggccagtg      120

agaatgaggg ccatagggaa gcttgaaatc atccctgcga gcctatcctg cccacgtgtt      180

gagatcattg ccacgatgaa aaagaatgat gagcagagat gtctgaatcc ggaatctaag      240

accatcaaga atttaatgaa agcgtttagc caaaaaaggt ctaaaagggc tcctggcgga      300

ggtggctctg gcggtggcgg atcgggcgga ggtggctctg tgcccaggga ttgtggttgt      360

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      420

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      480

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      540

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      600

atcatgcacc aggactgcct caatggcaag gagttcaaat gcagggtcaa cagtgcagct      660

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag      720

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc      780

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca      840

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac      900

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg      960

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1020


<210>  40
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  40

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Cys Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  41
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  41
gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc       60

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      120

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      180

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      240

cgctcagtca gtgaacttcc catcatgcac caggactgcc tcaatggcaa ggagttcaaa      300

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa      360

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag      420

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag      480

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca      540

gatggctctt acttcgtcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga      600

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc      660

ctctcccact ctcctggtaa a                                                681


<210>  42
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  42
ctcgaggtgc ccagggattg tggttg                                            26


<210>  43
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  43
gggcccttta ccaggagagt gggaga                                            26


<210>  44
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  44
gctagc                                                                   6


<210>  45
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  45
ctcgag                                                                   6


<210>  46
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gctagcATGAACCCAAGTGCTGCCGTCATTTT

<400>  46
000

<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  47
ctcgagagga gcccttttag accttttttg                                        30


