                         SEQUENCE LISTING

<110>  Adama Agan Ltd.
 
<120>  THE USE OF SAFENERS TO IMPROVE TOLERANCE OF ACCASE TOLERANT 
       SORGHUM CROP TO HERBICIDES

<130>  4.292

<150>  US 63/042,019
<151>  2020-06-22

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  ACC1 (TGG to TGC)

<400>  1
gcaaactctg gtgctaggat tggcatagct gatgaagtaa aatcttgctt ccgtgttggg       60

tggtctgacg aaggcagccc tgagcgaggg tttcagtaca tctatctgac tgaagaagac      120

tatgcccgta ttagctcttc tgttatagca cataagctgc agctagatag cggtgaaatt      180

aggtggatta ttgactctgt tgtgggcaag gaggatgggc ttggtgttga gaacatacat      240

ggaagtgctg ctatcgccag tgcttattct agggcatatg aggagacatt tacacttaca      300

tttgtgaccg gacggactgt aggaatagga gcttatcttg ctagacttgg tatacggtgc      360

atacagcgtc ttgaccagcc aattatttta acagggtttt ctgccctgaa caagctcctt      420

gggcgggaag tgtacagctc ccacatgcag cttggtggtc ctaagatcat ggcgaccaat      480

ggtgttgtcc acctgactgt tccagatgac cttgaaggtg tttccaatat attgaggtgg      540

ctcagctatg ttcctgcaaa cattggtgga cctcttccta ttaccaaacc tttggaccct      600

ccagacagac ctgttgcata catccctgag aacacatgcg atccacgtgc agccatccgt      660

ggtgtagatg acagccaagg gaaatggttg ggtggtatgt ttgacaaaga cagctttgtg      720

gagacatttg aaggatgggc aaaaacagtg gttactggca gagcaaagct tggaggaatt      780

cctgtgggtg tcatagctgt ggagacacag accatgatgc agcttgtccc tgctgatcca      840

ggtcagcttg attcccatga gcgatccgtt cctcgggctg gacaagtgtg cttcccagat      900

tctgcaacca agacagctca ggcattatta gacttcaacc gtgaaggatt gcctctgttt      960

atcctggcta actggagagg tttctctggt ggacagagag atctctttga aggaattctt     1020

caggctgggt caacaattgt cgagaacctt aggacatata atcagcctgc gtttgtctac     1080

attcctatgg ctggagagct tcgtggagga gcttgggttg tggtcgatag caaaataaat     1140

ccagaccgca ttgagtgtta tgctgagagg actgccaaag gtaatgttct cgaacctcaa     1200

gggttaattg aaatcaagtt caggtcagag gaactccaag actgtatggg taggcttgac     1260

cccgagttga taaatctgaa agcaaaactc caagatgtaa agcatggaaa tggaagtcta     1320

ccagacatag aatcccttca gaagagtata gaagcacgta cgaaacagtt gctgccttta     1380

tatacccaga ttgcaatacg gtttgctgaa ttgcatgata cttccctaag aatggcagct     1440

aaaggcgtga ttaagaaagt tgtagactgg gaagaatcac gctctttctt ctataaaagg     1500

ctacggagaa ggatctctga agatgttctt gcaaaagaaa taagacatat agtcggtgac     1560

aacttcactc accaatcagc aatggagctc atcaaggaat ggtacctggc ttctccagcc     1620

acagcaggaa gcactggatg ggatgacgat gatgcatttg ttgcctggaa ggacagtcct     1680

gaaaactaca atggatatat ccaagagcta agggctcaaa aagtgtctca gtcgctctct     1740

gatctcactg actccagttc agatctacaa gcattctcgc agggtctttc tacgctatta     1800

gataagatgg atccctctca aagagcgaag tttgttcagg aagtcaagaa ggtccttggt     1860

tga                                                                   1863


<210>  2
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  ACC2 (TGG to TCG)

<400>  2
gcaaactctg gtgctaggat tggcatagct gatgaagtaa aatcttgctt ccgtgttggg       60

tggtctgacg aaggcagccc tgagcgaggg tttcagtaca tctatctgac tgaagaagac      120

tatgcccgta ttagctcttc tgttatagca cataagctgc agctagatag cggtgaaatt      180

aggtggatta ttgactctgt tgtgggcaag gaggatgggc ttggtgttga gaacatacat      240

ggaagtgctg ctatcgccag tgcttattct agggcatatg aggagacatt tacacttaca      300

tttgtgaccg gacggactgt aggaatagga gcttatcttg ctagacttgg tatacggtgc      360

atacagcgtc ttgaccagcc aattatttta acagggtttt ctgccctgaa caagctcctt      420

gggcgggaag tgtacagctc ccacatgcag cttggtggtc ctaagatcat ggcgaccaat      480

ggtgttgtcc acctgactgt tccagatgac cttgaaggtg tttccaatat attgaggtgg      540

ctcagctatg ttcctgcaaa cattggtgga cctcttccta ttaccaaacc tttggaccct      600

ccagacagac ctgttgcata catccctgag aacacatgcg atccacgtgc agccatccgt      660

ggtgtagatg acagccaagg gaaatggttg ggtggtatgt ttgacaaaga cagctttgtg      720

gagacatttg aaggatgggc aaaaacagtg gttactggca gagcaaagct tggaggaatt      780

cctgtgggtg tcatagctgt ggagacacag accatgatgc agcttgtccc tgctgatcca      840

ggtcagcttg attcccatga gcgatccgtt cctcgggctg gacaagtgtc gttcccagat      900

tctgcaacca agacagctca ggcattatta gacttcaacc gtgaaggatt gcctctgttt      960

atcctggcta actggagagg tttctctggt ggacagagag atctctttga aggaattctt     1020

caggctgggt caacaattgt cgagaacctt aggacatata atcagcctgc gtttgtctac     1080

attcctatgg ctggagagct tcgtggagga gcttgggttg tggtcgatag caaaataaat     1140

ccagaccgca ttgagtgtta tgctgagagg actgccaaag gtaatgttct cgaacctcaa     1200

gggttaattg aaatcaagtt caggtcagag gaactccaag actgtatggg taggcttgac     1260

cccgagttga taaatctgaa agcaaaactc caagatgtaa agcatggaaa tggaagtcta     1320

ccagacatag aatcccttca gaagagtata gaagcacgta cgaaacagtt gctgccttta     1380

tatacccaga ttgcaatacg gtttgctgaa ttgcatgata cttccctaag aatggcagct     1440

aaaggcgtga ttaagaaagt tgtagactgg gaagaatcac gctctttctt ctataaaagg     1500

ctacggagaa ggatctctga agatgttctt gcaaaagaaa taagacatat agtcggtgac     1560

aacttcactc accaatcagc aatggagctc atcaaggaat ggtacctggc ttctccagcc     1620

acagcaggaa gcactggatg ggatgacgat gatgcatttg ttgcctggaa ggacagtcct     1680

gaaaactaca atggatatat ccaagagcta agggctcaaa aagtgtctca gtcgctctct     1740

gatctcactg actccagttc agatctacaa gcattctcgc agggtctttc tacgctatta     1800

gataagatgg atccctctca aagagcgaag tttgttcagg aagtcaagaa ggtccttggt     1860

tga                                                                   1863


<210>  3
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  ACC3 (GCA to GTA)

<400>  3
gcaaactctg gtgctaggat tggcatagct gatgaagtaa aatcttgctt ccgtgttggg       60

tggtctgacg aaggcagccc tgagcgaggg tttcagtaca tctatctgac tgaagaagac      120

tatgcccgta ttagctcttc tgttatagca cataagctgc agctagatag cggtgaaatt      180

aggtggatta ttgactctgt tgtgggcaag gaggatgggc ttggtgttga gaacatacat      240

ggaagtgctg ctatcgccag tgcttattct agggcatatg aggagacatt tacacttaca      300

tttgtgaccg gacggactgt aggaatagga gcttatcttg ctagacttgg tatacggtgc      360

atacagcgtc ttgaccagcc aattatttta acagggtttt ctgccctgaa caagctcctt      420

gggcgggaag tgtacagctc ccacatgcag cttggtggtc ctaagatcat ggcgaccaat      480

ggtgttgtcc acctgactgt tccagatgac cttgaaggtg tttccaatat attgaggtgg      540

ctcagctatg ttcctgcaaa cattggtgga cctcttccta ttaccaaacc tttggaccct      600

ccagacagac ctgttgcata catccctgag aacacatgcg atccacgtgc agccatccgt      660

ggtgtagatg acagccaagg gaaatggttg ggtggtatgt ttgacaaaga cagctttgtg      720

gagacatttg aaggatgggc aaaaacagtg gttactggca gagcaaagct tggaggaatt      780

cctgtgggtg tcatagctgt ggagacacag accatgatgc agcttgtccc tgctgatcca      840

ggtcagcttg attcccatga gcgatccgtt cctcgggctg gacaagtgtc gttcccagat      900

tctgtaacca agacagctca ggcattatta gacttcaacc gtgaaggatt gcctctgttt      960

atcctggcta actggagagg tttctctggt ggacagagag atctctttga aggaattctt     1020

caggctgggt caacaattgt cgagaacctt aggacatata atcagcctgc gtttgtctac     1080

attcctatgg ctggagagct tcgtggagga gcttgggttg tggtcgatag caaaataaat     1140

ccagaccgca ttgagtgtta tgctgagagg actgccaaag gtaatgttct cgaacctcaa     1200

gggttaattg aaatcaagtt caggtcagag gaactccaag actgtatggg taggcttgac     1260

cccgagttga taaatctgaa agcaaaactc caagatgtaa agcatggaaa tggaagtcta     1320

ccagacatag aatcccttca gaagagtata gaagcacgta cgaaacagtt gctgccttta     1380

tatacccaga ttgcaatacg gtttgctgaa ttgcatgata cttccctaag aatggcagct     1440

aaaggcgtga ttaagaaagt tgtagactgg gaagaatcac gctctttctt ctataaaagg     1500

ctacggagaa ggatctctga agatgttctt gcaaaagaaa taagacatat agtcggtgac     1560

aacttcactc accaatcagc aatggagctc atcaaggaat ggtacctggc ttctccagcc     1620

acagcaggaa gcactggatg ggatgacgat gatgcatttg ttgcctggaa ggacagtcct     1680

gaaaactaca atggatatat ccaagagcta agggctcaaa aagtgtctca gtcgctctct     1740

gatctcactg actccagttc agatctacaa gcattctcgc agggtctttc tacgctatta     1800

gataagatgg atccctctca aagagcgaag tttgttcagg aagtcaagaa ggtccttggt     1860

tga                                                                   1863


<210>  4
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  ACC4 (TGG to TCG)

<400>  4
gcaaactctg gtgctaggat tggcatagct gatgaagtaa aatcttgctt ccgtgttggg       60

tggtctgacg aaggcagccc tgagcgaggg tttcagtaca tctatctgac tgaagaagac      120

tatgcccgta ttagctcttc tgttatagca cataagctgc agctagatag cggtgaaatt      180

aggtggatta ttgactctgt tgtgggcaag gaggatgggc ttggtgttga gaacatacat      240

ggaagtgctg ctatcgccag tgcttattct agggcatatg aggagacatt tacacttaca      300

tttgtgaccg gacggactgt aggaatagga gcttatcttg ctagacttgg tatacggtgc      360

atacagcgtc ttgaccagcc aattatttta acagggtttt ctgccctgaa caagctcctt      420

gggcgggaag tgtacagctc ccacatgcag cttggtggtc ctaagatcat ggcgaccaat      480

ggtgttgtcc acctgactgt tccagatgac cttgaaggtg tttccaatat attgaggtgg      540

ctcagctatg ttcctgcaaa cattggtgga cctcttccta ttaccaaacc tttggaccct      600

ccagacagac ctgttgcata catccctgag aacacatgcg atccacgtgc agccatccgt      660

ggtgtagatg acagccaagg gaaatggttg ggtggtatgt ttgacaaaga cagctttgtg      720

gagacatttg aaggatgggc aaaaacagtg gttactggca gagcaaagct tggaggaatt      780

cctgtgggtg tcatagctgt ggagacacag accatgatgc agcttgtccc tgctgatcca      840

ggtcagcttg attcccatga gcgatccgtt cctcgggctg gacaagtgtc gttcccagat      900

tctgtaacca agacagctca ggcattatta gacttcaacc gtgaaggatt gcctctgttt      960

atcctggcta actcgagagg tttctctggt ggacagagag atctctttga aggaattctt     1020

caggctgggt caacaattgt cgagaacctt aggacatata atcagcctgc gtttgtctac     1080

attcctatgg ctggagagct tcgtggagga gcttgggttg tggtcgatag caaaataaat     1140

ccagaccgca ttgagtgtta tgctgagagg actgccaaag gtaatgttct cgaacctcaa     1200

gggttaattg aaatcaagtt caggtcagag gaactccaag actgtatggg taggcttgac     1260

cccgagttga taaatctgaa agcaaaactc caagatgtaa agcatggaaa tggaagtcta     1320

ccagacatag aatcccttca gaagagtata gaagcacgta cgaaacagtt gctgccttta     1380

tatacccaga ttgcaatacg gtttgctgaa ttgcatgata cttccctaag aatggcagct     1440

aaaggcgtga ttaagaaagt tgtagactgg gaagaatcac gctctttctt ctataaaagg     1500

ctacggagaa ggatctctga agatgttctt gcaaaagaaa taagacatat agtcggtgac     1560

aacttcactc accaatcagc aatggagctc atcaaggaat ggtacctggc ttctccagcc     1620

acagcaggaa gcactggatg ggatgacgat gatgcatttg ttgcctggaa ggacagtcct     1680

gaaaactaca atggatatat ccaagagcta agggctcaaa aagtgtctca gtcgctctct     1740

gatctcactg actccagttc agatctacaa gcattctcgc agggtctttc tacgctatta     1800

gataagatgg atccctctca aagagcgaag tttgttcagg aagtcaagaa ggtccttggt     1860

tga                                                                   1863


<210>  5
<211>  620
<212>  PRT
<213>  Sorghum


<220>
<221>  MISC_FEATURE
<223>  Sorghum Wild type CT domain sequence

<400>  5

Ala Asn Ser Gly Ala Arg Ile Gly Ile Ala Asp Glu Val Lys Ser Cys 
1               5                   10                  15      


Phe Arg Val Gly Trp Ser Asp Glu Gly Ser Pro Glu Arg Gly Phe Gln 
            20                  25                  30          


Tyr Ile Tyr Leu Thr Glu Glu Asp Tyr Ala Arg Ile Ser Ser Ser Val 
        35                  40                  45              


Ile Ala His Lys Leu Gln Leu Asp Ser Gly Glu Ile Arg Trp Ile Ile 
    50                  55                  60                  


Asp Ser Val Val Gly Lys Glu Asp Gly Leu Gly Val Glu Asn Ile His 
65                  70                  75                  80  


Gly Ser Ala Ala Ile Ala Ser Ala Tyr Ser Arg Ala Tyr Glu Glu Thr 
                85                  90                  95      


Phe Thr Leu Thr Phe Val Thr Gly Arg Thr Val Gly Ile Gly Ala Tyr 
            100                 105                 110         


Leu Ala Arg Leu Gly Ile Arg Cys Ile Gln Arg Leu Asp Gln Pro Ile 
        115                 120                 125             


Ile Leu Thr Gly Phe Ser Ala Leu Asn Lys Leu Leu Gly Arg Glu Val 
    130                 135                 140                 


Tyr Ser Ser His Met Gln Leu Gly Gly Pro Lys Ile Met Ala Thr Asn 
145                 150                 155                 160 


Gly Val Val His Leu Thr Val Pro Asp Asp Leu Glu Gly Val Ser Asn 
                165                 170                 175     


Ile Leu Arg Trp Leu Ser Tyr Val Pro Ala Asn Ile Gly Gly Pro Leu 
            180                 185                 190         


Pro Ile Thr Lys Pro Leu Asp Pro Pro Asp Arg Pro Val Ala Tyr Ile 
        195                 200                 205             


Pro Glu Asn Thr Cys Asp Pro Arg Ala Ala Ile Arg Gly Val Asp Asp 
    210                 215                 220                 


Ser Gln Gly Lys Trp Leu Gly Gly Met Phe Asp Lys Asp Ser Phe Val 
225                 230                 235                 240 


Glu Thr Phe Glu Gly Trp Ala Lys Thr Val Val Thr Gly Arg Ala Lys 
                245                 250                 255     


Leu Gly Gly Ile Pro Val Gly Val Ile Ala Val Glu Thr Gln Thr Met 
            260                 265                 270         


Met Gln Leu Val Pro Ala Asp Pro Gly Gln Leu Asp Ser His Glu Arg 
        275                 280                 285             


Ser Val Pro Arg Ala Gly Gln Val Trp Phe Pro Asp Ser Ala Thr Lys 
    290                 295                 300                 


Thr Ala Gln Ala Leu Leu Asp Phe Asn Arg Glu Gly Leu Pro Leu Phe 
305                 310                 315                 320 


Ile Leu Ala Asn Trp Arg Gly Phe Ser Gly Gly Gln Arg Asp Leu Phe 
                325                 330                 335     


Glu Gly Ile Leu Gln Ala Gly Ser Thr Ile Val Glu Asn Leu Arg Thr 
            340                 345                 350         


Tyr Asn Gln Pro Ala Phe Val Tyr Ile Pro Met Ala Gly Glu Leu Arg 
        355                 360                 365             


Gly Gly Ala Trp Val Val Val Asp Ser Lys Ile Asn Pro Asp Arg Ile 
    370                 375                 380                 


Glu Cys Tyr Ala Glu Arg Thr Ala Lys Gly Asn Val Leu Glu Pro Gln 
385                 390                 395                 400 


Gly Leu Ile Glu Ile Lys Phe Arg Ser Glu Glu Leu Gln Asp Cys Met 
                405                 410                 415     


Gly Arg Leu Asp Pro Glu Leu Ile Asn Leu Lys Ala Lys Leu Gln Asp 
            420                 425                 430         


Val Lys His Gly Asn Gly Ser Leu Pro Asp Ile Glu Ser Leu Gln Lys 
        435                 440                 445             


Ser Ile Glu Ala Arg Thr Lys Gln Leu Leu Pro Leu Tyr Thr Gln Ile 
    450                 455                 460                 


Ala Ile Arg Phe Ala Glu Leu His Asp Thr Ser Leu Arg Met Ala Ala 
465                 470                 475                 480 


Lys Gly Val Ile Lys Lys Val Val Asp Trp Glu Glu Ser Arg Ser Phe 
                485                 490                 495     


Phe Tyr Lys Arg Leu Arg Arg Arg Ile Ser Glu Asp Val Leu Ala Lys 
            500                 505                 510         


Glu Ile Arg His Ile Val Gly Asp Asn Phe Thr His Gln Ser Ala Met 
        515                 520                 525             


Glu Leu Ile Lys Glu Trp Tyr Leu Ala Ser Pro Ala Thr Ala Gly Ser 
    530                 535                 540                 


Thr Gly Trp Asp Asp Asp Asp Ala Phe Val Ala Trp Lys Asp Ser Pro 
545                 550                 555                 560 


Glu Asn Tyr Asn Gly Tyr Ile Gln Glu Leu Arg Ala Gln Lys Val Ser 
                565                 570                 575     


Gln Ser Leu Ser Asp Leu Thr Asp Ser Ser Ser Asp Leu Gln Ala Phe 
            580                 585                 590         


Ser Gln Gly Leu Ser Thr Leu Leu Asp Lys Met Asp Pro Ser Gln Arg 
        595                 600                 605             


Ala Lys Phe Val Gln Glu Val Lys Lys Val Leu Gly 
    610                 615                 620 


<210>  6
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  ACC1 (W1999C)

<400>  6

Ala Asn Ser Gly Ala Arg Ile Gly Ile Ala Asp Glu Val Lys Ser Cys 
1               5                   10                  15      


Phe Arg Val Gly Trp Ser Asp Glu Gly Ser Pro Glu Arg Gly Phe Gln 
            20                  25                  30          


Tyr Ile Tyr Leu Thr Glu Glu Asp Tyr Ala Arg Ile Ser Ser Ser Val 
        35                  40                  45              


Ile Ala His Lys Leu Gln Leu Asp Ser Gly Glu Ile Arg Trp Ile Ile 
    50                  55                  60                  


Asp Ser Val Val Gly Lys Glu Asp Gly Leu Gly Val Glu Asn Ile His 
65                  70                  75                  80  


Gly Ser Ala Ala Ile Ala Ser Ala Tyr Ser Arg Ala Tyr Glu Glu Thr 
                85                  90                  95      


Phe Thr Leu Thr Phe Val Thr Gly Arg Thr Val Gly Ile Gly Ala Tyr 
            100                 105                 110         


Leu Ala Arg Leu Gly Ile Arg Cys Ile Gln Arg Leu Asp Gln Pro Ile 
        115                 120                 125             


Ile Leu Thr Gly Phe Ser Ala Leu Asn Lys Leu Leu Gly Arg Glu Val 
    130                 135                 140                 


Tyr Ser Ser His Met Gln Leu Gly Gly Pro Lys Ile Met Ala Thr Asn 
145                 150                 155                 160 


Gly Val Val His Leu Thr Val Pro Asp Asp Leu Glu Gly Val Ser Asn 
                165                 170                 175     


Ile Leu Arg Trp Leu Ser Tyr Val Pro Ala Asn Ile Gly Gly Pro Leu 
            180                 185                 190         


Pro Ile Thr Lys Pro Leu Asp Pro Pro Asp Arg Pro Val Ala Tyr Ile 
        195                 200                 205             


Pro Glu Asn Thr Cys Asp Pro Arg Ala Ala Ile Arg Gly Val Asp Asp 
    210                 215                 220                 


Ser Gln Gly Lys Trp Leu Gly Gly Met Phe Asp Lys Asp Ser Phe Val 
225                 230                 235                 240 


Glu Thr Phe Glu Gly Trp Ala Lys Thr Val Val Thr Gly Arg Ala Lys 
                245                 250                 255     


Leu Gly Gly Ile Pro Val Gly Val Ile Ala Val Glu Thr Gln Thr Met 
            260                 265                 270         


Met Gln Leu Val Pro Ala Asp Pro Gly Gln Leu Asp Ser His Glu Arg 
        275                 280                 285             


Ser Val Pro Arg Ala Gly Gln Val Cys Phe Pro Asp Ser Ala Thr Lys 
    290                 295                 300                 


Thr Ala Gln Ala Leu Leu Asp Phe Asn Arg Glu Gly Leu Pro Leu Phe 
305                 310                 315                 320 


Ile Leu Ala Asn Trp Arg Gly Phe Ser Gly Gly Gln Arg Asp Leu Phe 
                325                 330                 335     


Glu Gly Ile Leu Gln Ala Gly Ser Thr Ile Val Glu Asn Leu Arg Thr 
            340                 345                 350         


Tyr Asn Gln Pro Ala Phe Val Tyr Ile Pro Met Ala Gly Glu Leu Arg 
        355                 360                 365             


Gly Gly Ala Trp Val Val Val Asp Ser Lys Ile Asn Pro Asp Arg Ile 
    370                 375                 380                 


Glu Cys Tyr Ala Glu Arg Thr Ala Lys Gly Asn Val Leu Glu Pro Gln 
385                 390                 395                 400 


Gly Leu Ile Glu Ile Lys Phe Arg Ser Glu Glu Leu Gln Asp Cys Met 
                405                 410                 415     


Gly Arg Leu Asp Pro Glu Leu Ile Asn Leu Lys Ala Lys Leu Gln Asp 
            420                 425                 430         


Val Lys His Gly Asn Gly Ser Leu Pro Asp Ile Glu Ser Leu Gln Lys 
        435                 440                 445             


Ser Ile Glu Ala Arg Thr Lys Gln Leu Leu Pro Leu Tyr Thr Gln Ile 
    450                 455                 460                 


Ala Ile Arg Phe Ala Glu Leu His Asp Thr Ser Leu Arg Met Ala Ala 
465                 470                 475                 480 


Lys Gly Val Ile Lys Lys Val Val Asp Trp Glu Glu Ser Arg Ser Phe 
                485                 490                 495     


Phe Tyr Lys Arg Leu Arg Arg Arg Ile Ser Glu Asp Val Leu Ala Lys 
            500                 505                 510         


Glu Ile Arg His Ile Val Gly Asp Asn Phe Thr His Gln Ser Ala Met 
        515                 520                 525             


Glu Leu Ile Lys Glu Trp Tyr Leu Ala Ser Pro Ala Thr Ala Gly Ser 
    530                 535                 540                 


Thr Gly Trp Asp Asp Asp Asp Ala Phe Val Ala Trp Lys Asp Ser Pro 
545                 550                 555                 560 


Glu Asn Tyr Asn Gly Tyr Ile Gln Glu Leu Arg Ala Gln Lys Val Ser 
                565                 570                 575     


Gln Ser Leu Ser Asp Leu Thr Asp Ser Ser Ser Asp Leu Gln Ala Phe 
            580                 585                 590         


Ser Gln Gly Leu Ser Thr Leu Leu Asp Lys Met Asp Pro Ser Gln Arg 
        595                 600                 605             


Ala Lys Phe Val Gln Glu Val Lys Lys Val Leu Gly 
    610                 615                 620 


<210>  7
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  ACC2 (W1999S)

<400>  7

Ala Asn Ser Gly Ala Arg Ile Gly Ile Ala Asp Glu Val Lys Ser Cys 
1               5                   10                  15      


Phe Arg Val Gly Trp Ser Asp Glu Gly Ser Pro Glu Arg Gly Phe Gln 
            20                  25                  30          


Tyr Ile Tyr Leu Thr Glu Glu Asp Tyr Ala Arg Ile Ser Ser Ser Val 
        35                  40                  45              


Ile Ala His Lys Leu Gln Leu Asp Ser Gly Glu Ile Arg Trp Ile Ile 
    50                  55                  60                  


Asp Ser Val Val Gly Lys Glu Asp Gly Leu Gly Val Glu Asn Ile His 
65                  70                  75                  80  


Gly Ser Ala Ala Ile Ala Ser Ala Tyr Ser Arg Ala Tyr Glu Glu Thr 
                85                  90                  95      


Phe Thr Leu Thr Phe Val Thr Gly Arg Thr Val Gly Ile Gly Ala Tyr 
            100                 105                 110         


Leu Ala Arg Leu Gly Ile Arg Cys Ile Gln Arg Leu Asp Gln Pro Ile 
        115                 120                 125             


Ile Leu Thr Gly Phe Ser Ala Leu Asn Lys Leu Leu Gly Arg Glu Val 
    130                 135                 140                 


Tyr Ser Ser His Met Gln Leu Gly Gly Pro Lys Ile Met Ala Thr Asn 
145                 150                 155                 160 


Gly Val Val His Leu Thr Val Pro Asp Asp Leu Glu Gly Val Ser Asn 
                165                 170                 175     


Ile Leu Arg Trp Leu Ser Tyr Val Pro Ala Asn Ile Gly Gly Pro Leu 
            180                 185                 190         


Pro Ile Thr Lys Pro Leu Asp Pro Pro Asp Arg Pro Val Ala Tyr Ile 
        195                 200                 205             


Pro Glu Asn Thr Cys Asp Pro Arg Ala Ala Ile Arg Gly Val Asp Asp 
    210                 215                 220                 


Ser Gln Gly Lys Trp Leu Gly Gly Met Phe Asp Lys Asp Ser Phe Val 
225                 230                 235                 240 


Glu Thr Phe Glu Gly Trp Ala Lys Thr Val Val Thr Gly Arg Ala Lys 
                245                 250                 255     


Leu Gly Gly Ile Pro Val Gly Val Ile Ala Val Glu Thr Gln Thr Met 
            260                 265                 270         


Met Gln Leu Val Pro Ala Asp Pro Gly Gln Leu Asp Ser His Glu Arg 
        275                 280                 285             


Ser Val Pro Arg Ala Gly Gln Val Ser Phe Pro Asp Ser Ala Thr Lys 
    290                 295                 300                 


Thr Ala Gln Ala Leu Leu Asp Phe Asn Arg Glu Gly Leu Pro Leu Phe 
305                 310                 315                 320 


Ile Leu Ala Asn Trp Arg Gly Phe Ser Gly Gly Gln Arg Asp Leu Phe 
                325                 330                 335     


Glu Gly Ile Leu Gln Ala Gly Ser Thr Ile Val Glu Asn Leu Arg Thr 
            340                 345                 350         


Tyr Asn Gln Pro Ala Phe Val Tyr Ile Pro Met Ala Gly Glu Leu Arg 
        355                 360                 365             


Gly Gly Ala Trp Val Val Val Asp Ser Lys Ile Asn Pro Asp Arg Ile 
    370                 375                 380                 


Glu Cys Tyr Ala Glu Arg Thr Ala Lys Gly Asn Val Leu Glu Pro Gln 
385                 390                 395                 400 


Gly Leu Ile Glu Ile Lys Phe Arg Ser Glu Glu Leu Gln Asp Cys Met 
                405                 410                 415     


Gly Arg Leu Asp Pro Glu Leu Ile Asn Leu Lys Ala Lys Leu Gln Asp 
            420                 425                 430         


Val Lys His Gly Asn Gly Ser Leu Pro Asp Ile Glu Ser Leu Gln Lys 
        435                 440                 445             


Ser Ile Glu Ala Arg Thr Lys Gln Leu Leu Pro Leu Tyr Thr Gln Ile 
    450                 455                 460                 


Ala Ile Arg Phe Ala Glu Leu His Asp Thr Ser Leu Arg Met Ala Ala 
465                 470                 475                 480 


Lys Gly Val Ile Lys Lys Val Val Asp Trp Glu Glu Ser Arg Ser Phe 
                485                 490                 495     


Phe Tyr Lys Arg Leu Arg Arg Arg Ile Ser Glu Asp Val Leu Ala Lys 
            500                 505                 510         


Glu Ile Arg His Ile Val Gly Asp Asn Phe Thr His Gln Ser Ala Met 
        515                 520                 525             


Glu Leu Ile Lys Glu Trp Tyr Leu Ala Ser Pro Ala Thr Ala Gly Ser 
    530                 535                 540                 


Thr Gly Trp Asp Asp Asp Asp Ala Phe Val Ala Trp Lys Asp Ser Pro 
545                 550                 555                 560 


Glu Asn Tyr Asn Gly Tyr Ile Gln Glu Leu Arg Ala Gln Lys Val Ser 
                565                 570                 575     


Gln Ser Leu Ser Asp Leu Thr Asp Ser Ser Ser Asp Leu Gln Ala Phe 
            580                 585                 590         


Ser Gln Gly Leu Ser Thr Leu Leu Asp Lys Met Asp Pro Ser Gln Arg 
        595                 600                 605             


Ala Lys Phe Val Gln Glu Val Lys Lys Val Leu Gly 
    610                 615                 620 


<210>  8
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  ACC3 (A2004V)

<400>  8

Ala Asn Ser Gly Ala Arg Ile Gly Ile Ala Asp Glu Val Lys Ser Cys 
1               5                   10                  15      


Phe Arg Val Gly Trp Ser Asp Glu Gly Ser Pro Glu Arg Gly Phe Gln 
            20                  25                  30          


Tyr Ile Tyr Leu Thr Glu Glu Asp Tyr Ala Arg Ile Ser Ser Ser Val 
        35                  40                  45              


Ile Ala His Lys Leu Gln Leu Asp Ser Gly Glu Ile Arg Trp Ile Ile 
    50                  55                  60                  


Asp Ser Val Val Gly Lys Glu Asp Gly Leu Gly Val Glu Asn Ile His 
65                  70                  75                  80  


Gly Ser Ala Ala Ile Ala Ser Ala Tyr Ser Arg Ala Tyr Glu Glu Thr 
                85                  90                  95      


Phe Thr Leu Thr Phe Val Thr Gly Arg Thr Val Gly Ile Gly Ala Tyr 
            100                 105                 110         


Leu Ala Arg Leu Gly Ile Arg Cys Ile Gln Arg Leu Asp Gln Pro Ile 
        115                 120                 125             


Ile Leu Thr Gly Phe Ser Ala Leu Asn Lys Leu Leu Gly Arg Glu Val 
    130                 135                 140                 


Tyr Ser Ser His Met Gln Leu Gly Gly Pro Lys Ile Met Ala Thr Asn 
145                 150                 155                 160 


Gly Val Val His Leu Thr Val Pro Asp Asp Leu Glu Gly Val Ser Asn 
                165                 170                 175     


Ile Leu Arg Trp Leu Ser Tyr Val Pro Ala Asn Ile Gly Gly Pro Leu 
            180                 185                 190         


Pro Ile Thr Lys Pro Leu Asp Pro Pro Asp Arg Pro Val Ala Tyr Ile 
        195                 200                 205             


Pro Glu Asn Thr Cys Asp Pro Arg Ala Ala Ile Arg Gly Val Asp Asp 
    210                 215                 220                 


Ser Gln Gly Lys Trp Leu Gly Gly Met Phe Asp Lys Asp Ser Phe Val 
225                 230                 235                 240 


Glu Thr Phe Glu Gly Trp Ala Lys Thr Val Val Thr Gly Arg Ala Lys 
                245                 250                 255     


Leu Gly Gly Ile Pro Val Gly Val Ile Ala Val Glu Thr Gln Thr Met 
            260                 265                 270         


Met Gln Leu Val Pro Ala Asp Pro Gly Gln Leu Asp Ser His Glu Arg 
        275                 280                 285             


Ser Val Pro Arg Ala Gly Gln Val Trp Phe Pro Asp Ser Val Thr Lys 
    290                 295                 300                 


Thr Ala Gln Ala Leu Leu Asp Phe Asn Arg Glu Gly Leu Pro Leu Phe 
305                 310                 315                 320 


Ile Leu Ala Asn Trp Arg Gly Phe Ser Gly Gly Gln Arg Asp Leu Phe 
                325                 330                 335     


Glu Gly Ile Leu Gln Ala Gly Ser Thr Ile Val Glu Asn Leu Arg Thr 
            340                 345                 350         


Tyr Asn Gln Pro Ala Phe Val Tyr Ile Pro Met Ala Gly Glu Leu Arg 
        355                 360                 365             


Gly Gly Ala Trp Val Val Val Asp Ser Lys Ile Asn Pro Asp Arg Ile 
    370                 375                 380                 


Glu Cys Tyr Ala Glu Arg Thr Ala Lys Gly Asn Val Leu Glu Pro Gln 
385                 390                 395                 400 


Gly Leu Ile Glu Ile Lys Phe Arg Ser Glu Glu Leu Gln Asp Cys Met 
                405                 410                 415     


Gly Arg Leu Asp Pro Glu Leu Ile Asn Leu Lys Ala Lys Leu Gln Asp 
            420                 425                 430         


Val Lys His Gly Asn Gly Ser Leu Pro Asp Ile Glu Ser Leu Gln Lys 
        435                 440                 445             


Ser Ile Glu Ala Arg Thr Lys Gln Leu Leu Pro Leu Tyr Thr Gln Ile 
    450                 455                 460                 


Ala Ile Arg Phe Ala Glu Leu His Asp Thr Ser Leu Arg Met Ala Ala 
465                 470                 475                 480 


Lys Gly Val Ile Lys Lys Val Val Asp Trp Glu Glu Ser Arg Ser Phe 
                485                 490                 495     


Phe Tyr Lys Arg Leu Arg Arg Arg Ile Ser Glu Asp Val Leu Ala Lys 
            500                 505                 510         


Glu Ile Arg His Ile Val Gly Asp Asn Phe Thr His Gln Ser Ala Met 
        515                 520                 525             


Glu Leu Ile Lys Glu Trp Tyr Leu Ala Ser Pro Ala Thr Ala Gly Ser 
    530                 535                 540                 


Thr Gly Trp Asp Asp Asp Asp Ala Phe Val Ala Trp Lys Asp Ser Pro 
545                 550                 555                 560 


Glu Asn Tyr Asn Gly Tyr Ile Gln Glu Leu Arg Ala Gln Lys Val Ser 
                565                 570                 575     


Gln Ser Leu Ser Asp Leu Thr Asp Ser Ser Ser Asp Leu Gln Ala Phe 
            580                 585                 590         


Ser Gln Gly Leu Ser Thr Leu Leu Asp Lys Met Asp Pro Ser Gln Arg 
        595                 600                 605             


Ala Lys Phe Val Gln Glu Val Lys Lys Val Leu Gly 
    610                 615                 620 


<210>  9
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  ACC4 (W2027S)

<400>  9

Ala Asn Ser Gly Ala Arg Ile Gly Ile Ala Asp Glu Val Lys Ser Cys 
1               5                   10                  15      


Phe Arg Val Gly Trp Ser Asp Glu Gly Ser Pro Glu Arg Gly Phe Gln 
            20                  25                  30          


Tyr Ile Tyr Leu Thr Glu Glu Asp Tyr Ala Arg Ile Ser Ser Ser Val 
        35                  40                  45              


Ile Ala His Lys Leu Gln Leu Asp Ser Gly Glu Ile Arg Trp Ile Ile 
    50                  55                  60                  


Asp Ser Val Val Gly Lys Glu Asp Gly Leu Gly Val Glu Asn Ile His 
65                  70                  75                  80  


Gly Ser Ala Ala Ile Ala Ser Ala Tyr Ser Arg Ala Tyr Glu Glu Thr 
                85                  90                  95      


Phe Thr Leu Thr Phe Val Thr Gly Arg Thr Val Gly Ile Gly Ala Tyr 
            100                 105                 110         


Leu Ala Arg Leu Gly Ile Arg Cys Ile Gln Arg Leu Asp Gln Pro Ile 
        115                 120                 125             


Ile Leu Thr Gly Phe Ser Ala Leu Asn Lys Leu Leu Gly Arg Glu Val 
    130                 135                 140                 


Tyr Ser Ser His Met Gln Leu Gly Gly Pro Lys Ile Met Ala Thr Asn 
145                 150                 155                 160 


Gly Val Val His Leu Thr Val Pro Asp Asp Leu Glu Gly Val Ser Asn 
                165                 170                 175     


Ile Leu Arg Trp Leu Ser Tyr Val Pro Ala Asn Ile Gly Gly Pro Leu 
            180                 185                 190         


Pro Ile Thr Lys Pro Leu Asp Pro Pro Asp Arg Pro Val Ala Tyr Ile 
        195                 200                 205             


Pro Glu Asn Thr Cys Asp Pro Arg Ala Ala Ile Arg Gly Val Asp Asp 
    210                 215                 220                 


Ser Gln Gly Lys Trp Leu Gly Gly Met Phe Asp Lys Asp Ser Phe Val 
225                 230                 235                 240 


Glu Thr Phe Glu Gly Trp Ala Lys Thr Val Val Thr Gly Arg Ala Lys 
                245                 250                 255     


Leu Gly Gly Ile Pro Val Gly Val Ile Ala Val Glu Thr Gln Thr Met 
            260                 265                 270         


Met Gln Leu Val Pro Ala Asp Pro Gly Gln Leu Asp Ser His Glu Arg 
        275                 280                 285             


Ser Val Pro Arg Ala Gly Gln Val Trp Phe Pro Asp Ser Ala Thr Lys 
    290                 295                 300                 


Thr Ala Gln Ala Leu Leu Asp Phe Asn Arg Glu Gly Leu Pro Leu Phe 
305                 310                 315                 320 


Ile Leu Ala Asn Ser Arg Gly Phe Ser Gly Gly Gln Arg Asp Leu Phe 
                325                 330                 335     


Glu Gly Ile Leu Gln Ala Gly Ser Thr Ile Val Glu Asn Leu Arg Thr 
            340                 345                 350         


Tyr Asn Gln Pro Ala Phe Val Tyr Ile Pro Met Ala Gly Glu Leu Arg 
        355                 360                 365             


Gly Gly Ala Trp Val Val Val Asp Ser Lys Ile Asn Pro Asp Arg Ile 
    370                 375                 380                 


Glu Cys Tyr Ala Glu Arg Thr Ala Lys Gly Asn Val Leu Glu Pro Gln 
385                 390                 395                 400 


Gly Leu Ile Glu Ile Lys Phe Arg Ser Glu Glu Leu Gln Asp Cys Met 
                405                 410                 415     


Gly Arg Leu Asp Pro Glu Leu Ile Asn Leu Lys Ala Lys Leu Gln Asp 
            420                 425                 430         


Val Lys His Gly Asn Gly Ser Leu Pro Asp Ile Glu Ser Leu Gln Lys 
        435                 440                 445             


Ser Ile Glu Ala Arg Thr Lys Gln Leu Leu Pro Leu Tyr Thr Gln Ile 
    450                 455                 460                 


Ala Ile Arg Phe Ala Glu Leu His Asp Thr Ser Leu Arg Met Ala Ala 
465                 470                 475                 480 


Lys Gly Val Ile Lys Lys Val Val Asp Trp Glu Glu Ser Arg Ser Phe 
                485                 490                 495     


Phe Tyr Lys Arg Leu Arg Arg Arg Ile Ser Glu Asp Val Leu Ala Lys 
            500                 505                 510         


Glu Ile Arg His Ile Val Gly Asp Asn Phe Thr His Gln Ser Ala Met 
        515                 520                 525             


Glu Leu Ile Lys Glu Trp Tyr Leu Ala Ser Pro Ala Thr Ala Gly Ser 
    530                 535                 540                 


Thr Gly Trp Asp Asp Asp Asp Ala Phe Val Ala Trp Lys Asp Ser Pro 
545                 550                 555                 560 


Glu Asn Tyr Asn Gly Tyr Ile Gln Glu Leu Arg Ala Gln Lys Val Ser 
                565                 570                 575     


Gln Ser Leu Ser Asp Leu Thr Asp Ser Ser Ser Asp Leu Gln Ala Phe 
            580                 585                 590         


Ser Gln Gly Leu Ser Thr Leu Leu Asp Lys Met Asp Pro Ser Gln Arg 
        595                 600                 605             


Ala Lys Phe Val Gln Glu Val Lys Lys Val Leu Gly 
    610                 615                 620 


