                         SEQUENCE LISTING

<110>  CRISPR Therapeutics AG
 
<120>  ALLOGENEIC CELL THERAPY OF B CELL MALIGNANCIES USING GENETICALLY 
       ENGINEERED T CELLS TARGETING CD19

<130>  095136-0334-027WO1

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/044,456
<151>  2020-06-26

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
aagagcaaca aatctgact                                                    19


<210>  2
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
aagagcaaca gtgctgtgcc tggagcaaca aatctgacta agagcaacaa atctgact         58


<210>  3
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
aagagcaaca gtgctggagc aacaaatctg actaagagca acaaatctga ct               52


<210>  4
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
aagagcaaca gtgcctggag caacaaatct gactaagagc aacaaatctg act              53


<210>  5
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
aagagcaaca gtgctgacta agagcaacaa atctgact                               38


<210>  6
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
aagagcaaca gtgctgtggg cctggagcaa caaatctgac taagagcaac aaatctgact       60


<210>  7
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
aagagcaaca gtgctggcct ggagcaacaa atctgactaa gagcaacaaa tctgact          57


<210>  8
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
aagagcaaca gtgctgtgtg cctggagcaa caaatctgac taagagcaac aaatctgact       60


<210>  9
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
cgtggcctta gctgtgctcg cgctactctc tctttctgcc tggaggctat ccagcgtgag       60

tctctcctac cctcccgct                                                    79


<210>  10
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
cgtggcctta gctgtgctcg cgctactctc tctttcgcct ggaggctatc cagcgtgagt       60

ctctcctacc ctcccgct                                                     78


<210>  11
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
cgtggcctta gctgtgctcg cgctactctc tctttctgga ggctatccag cgtgagtctc       60

tcctaccctc ccgct                                                        75


<210>  12
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
cgtggcctta gctgtgctcg cgctactctc tctttctgga tagcctggag gctatccagc       60

gtgagtctct cctaccctcc cgct                                              84


<210>  13
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
cgtggcctta gctgtgctcg cgctatccag cgtgagtctc tcctaccctc ccgct            55


<210>  14
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
cgtggcctta gctgtgctcg cgctactctc tctttctgtg gcctggaggc tatccagcgt       60

gagtctctcc taccctcccg ct                                                82


<210>  15
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  15
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  16
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  16
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  17
<211>  114
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (18)..(30)
<223>  may be absent

<220>
<221>  misc_feature
<222>  (108)..(114)
<223>  may be absent

<400>  17
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uuuu            114


<210>  18
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
agagcaacag ugcuguggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  19
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
agagcaacag ugcuguggcc                                                   20


<210>  20
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gcuacucucu cuuucuggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  21
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
gcuacucucu cuuucuggcc                                                   20


<210>  22
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  22
agagcaacag ugcuguggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  23
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  23
agagcaacag ugcuguggcc                                                   20


<210>  24
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  24
gcuacucucu cuuucuggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  25
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  25
gcuacucucu cuuucuggcc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
agagcaacag tgctgtggcc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
gctactctct ctttctggcc                                                   20


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
agagcaacag tgctgtggcc tgg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gctactctct ctttctggcc tgg                                               23


<210>  30
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  32
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  33
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  34
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  35
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
tcaaagcgga gtaggttgtt gcattccgat tacatgaata tgactcctcg ccggcctggg       60

ccgacaagaa aacattacca accctatgcc cccccacgag acttcgctgc gtacaggtcc      120


<210>  36
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  37
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
cgagtgaagt tttcccgaag cgcagacgct ccggcatatc agcaaggaca gaatcagctg       60

tataacgaac tgaatttggg acgccgcgag gagtatgacg tgcttgataa acgccggggg      120

agagacccgg aaatgggggg taaaccccga agaaagaatc cccaagaagg actctacaat      180

gaactccaga aggataagat ggcggaggcc tactcagaaa taggtatgaa gggcgaacga      240

cgacggggaa aaggtcacga tggcctctac caagggttga gtacggcaac caaagatacg      300

tacgatgcac tgcatatgca ggccctgcct cccaga                                336


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  39
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
atgcttcttt tggttacgtc tctgttgctt tgcgaacttc ctcatccagc gttcttgctg       60

atccccgata ttcagatgac tcagaccacc agtagcttgt ctgcctcact gggagaccga      120

gtaacaatct cctgcagggc aagtcaagac attagcaaat acctcaattg gtaccagcag      180

aagcccgacg gaacggtaaa actcctcatc tatcatacgt caaggttgca ttccggagta      240

ccgtcacgat tttcaggttc tgggagcgga actgactatt ccttgactat ttcaaacctc      300

gagcaggagg acattgcgac atatttttgt caacaaggta ataccctccc ttacactttc      360

ggaggaggaa ccaaactcga aattaccggg tccaccagtg gctctgggaa gcctggcagt      420

ggagaaggtt ccactaaagg cgaggtgaag ctccaggaga gcggccccgg tctcgttgcc      480

cccagtcaaa gcctctctgt aacgtgcaca gtgagtggtg tatcattgcc tgattatggc      540

gtctcctgga taaggcagcc cccgcgaaag ggtcttgaat ggcttggggt aatatggggc      600

tcagagacaa cgtattataa ctccgctctc aaaagtcgct tgacgataat aaaagataac      660

tccaagagtc aagttttcct taaaatgaac agtttgcaga ctgacgatac cgctatatat      720

tattgtgcta aacattatta ctacggcggt agttacgcga tggattattg ggggcagggg      780

acttctgtca cagtcagtag tgctgctgcc tttgtcccgg tatttctccc agccaaaccg      840

accacgactc ccgccccgcg ccctccgaca cccgctccca ccatcgcctc tcaacctctt      900

agtcttcgcc ccgaggcatg ccgacccgcc gccgggggtg ctgttcatac gaggggcttg      960

gacttcgctt gtgatattta catttgggct ccgttggcgg gtacgtgcgg cgtccttttg     1020

ttgtcactcg ttattacttt gtattgtaat cacaggaatc gctcaaagcg gagtaggttg     1080

ttgcattccg attacatgaa tatgactcct cgccggcctg ggccgacaag aaaacattac     1140

caaccctatg cccccccacg agacttcgct gcgtacaggt cccgagtgaa gttttcccga     1200

agcgcagacg ctccggcata tcagcaagga cagaatcagc tgtataacga actgaatttg     1260

ggacgccgcg aggagtatga cgtgcttgat aaacgccggg ggagagaccc ggaaatgggg     1320

ggtaaacccc gaagaaagaa tccccaagaa ggactctaca atgaactcca gaaggataag     1380

atggcggagg cctactcaga aataggtatg aagggcgaac gacgacgggg aaaaggtcac     1440

gatggcctct accaagggtt gagtacggca accaaagata cgtacgatgc actgcatatg     1500

caggccctgc ctcccaga                                                   1518


<210>  40
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        355                 360                 365             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    370                 375                 380                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505     


<210>  41
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca                                                  800


<210>  42
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa       60

gacaccttct tccccagccc aggtaagggc agctttggtg ccttcgcagg ctgtttcctt      120

gcttcaggaa tggccaggtt ctgcccagag ctctggtcaa tgatgtctaa aactcctctg      180

attggtggtc tcggccttat ccattgccac caaaaccctc tttttactaa gaaacagtga      240

gccttgttct ggcagtccag agaatgacac gggaaaaaag cagatgaaga gaaggtggca      300

ggagagggca cgtggcccag cctcagtctc tccaactgag ttcctgcctg cctgcctttg      360

ctcagactgt ttgcccctta ctgctcttct aggcctcatt ctaagcccct tctccaagtt      420

gcctctcctt atttctccct gtctgccaaa aaatctttcc cagctcacta agtcagtctc      480

acgcagtcac tcattaaccc accaatcact gattgtgccg gcacatgaat gcaccaggtg      540

ttgaagtgga ggaattaaaa agtcagatga ggggtgtgcc cagaggaagc accattctag      600

ttgggggagc ccatctgtca gctgggaaaa gtccaaataa cttcagattg gaatgtgttt      660

taactcaggg ttgagaaaac agctaccttc aggacaaaag tcagggaagg gctctctgaa      720

gaaatgctac ttgaagatac cagccctacc aagggcaggg agaggaccct atagaggcct      780

gggacaggag ctcaatgaga aagg                                             804


<210>  43
<211>  1178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccactg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360

agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540

aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600

cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt      960

agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080

tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140

tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178


<210>  44
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
atgcttcttt tggttacgtc tctgttgctt tgcgaacttc ctcatccagc gttcttgctg       60

atcccc                                                                  66


<210>  45
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  46
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
gatattcaga tgactcagac caccagtagc ttgtctgcct cactgggaga ccgagtaaca       60

atctcctgca gggcaagtca agacattagc aaatacctca attggtacca gcagaagccc      120

gacggaacgg taaaactcct catctatcat acgtcaaggt tgcattccgg agtaccgtca      180

cgattttcag gttctgggag cggaactgac tattccttga ctatttcaaa cctcgagcag      240

gaggacattg cgacatattt ttgtcaacaa ggtaataccc tcccttacac tttcggagga      300

ggaaccaaac tcgaaattac cgggtccacc agtggctctg ggaagcctgg cagtggagaa      360

ggttccacta aaggcgaggt gaagctccag gagagcggcc ccggtctcgt tgcccccagt      420

caaagcctct ctgtaacgtg cacagtgagt ggtgtatcat tgcctgatta tggcgtctcc      480

tggataaggc agcccccgcg aaagggtctt gaatggcttg gggtaatatg gggctcagag      540

acaacgtatt ataactccgc tctcaaaagt cgcttgacga taataaaaga taactccaag      600

agtcaagttt tccttaaaat gaacagtttg cagactgacg ataccgctat atattattgt      660

gctaaacatt attactacgg cggtagttac gcgatggatt attgggggca ggggacttct      720

gtcacagtca gtagt                                                       735


<210>  47
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  48
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gctgctgcct ttgtcccggt atttctccca gccaaaccga ccacgactcc cgccccgcgc       60

cctccgacac ccgctcccac catcgcctct caacctctta gtcttcgccc cgaggcatgc      120

cgacccgccg ccgggggtgc tgttcatacg aggggcttgg acttcgcttg tgatatttac      180

atttgggctc cgttggcggg tacgtgcggc gtccttttgt tgtcactcgt tattactttg      240

tattgtaatc acaggaatcg c                                                261


<210>  49
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
tttgtcccgg tatttctccc agccaaaccg accacgactc ccgccccgcg ccctccgaca       60

cccgctccca ccatcgcctc tcaacctctt agtcttcgcc ccgaggcatg ccgacccgcc      120

gccgggggtg ctgttcatac gaggggcttg gacttcgctt gtgatattta catttgggct      180

ccgttggcgg gtacgtgcgg cgtccttttg ttgtcactcg ttattacttt gtattgtaat      240

cacaggaatc gc                                                          252


<210>  50
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  51
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  52
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  53
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  54
<211>  4358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca ggctccggtg cccgtcagtg ggcagagcgc acatcgccca      840

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc      900

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg      960

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     1020

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     1080

gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg atcccgagct     1140

tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg     1200

tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct     1260

tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc     1320

tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg     1380

tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc     1440

ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg     1500

ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag     1560

gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc     1620

agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca     1680

aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc     1740

gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg     1800

ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc     1860

agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt     1920

cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtgacc     1980

accatgcttc ttttggttac gtctctgttg ctttgcgaac ttcctcatcc agcgttcttg     2040

ctgatccccg atattcagat gactcagacc accagtagct tgtctgcctc actgggagac     2100

cgagtaacaa tctcctgcag ggcaagtcaa gacattagca aatacctcaa ttggtaccag     2160

cagaagcccg acggaacggt aaaactcctc atctatcata cgtcaaggtt gcattccgga     2220

gtaccgtcac gattttcagg ttctgggagc ggaactgact attccttgac tatttcaaac     2280

ctcgagcagg aggacattgc gacatatttt tgtcaacaag gtaataccct cccttacact     2340

ttcggaggag gaaccaaact cgaaattacc gggtccacca gtggctctgg gaagcctggc     2400

agtggagaag gttccactaa aggcgaggtg aagctccagg agagcggccc cggtctcgtt     2460

gcccccagtc aaagcctctc tgtaacgtgc acagtgagtg gtgtatcatt gcctgattat     2520

ggcgtctcct ggataaggca gcccccgcga aagggtcttg aatggcttgg ggtaatatgg     2580

ggctcagaga caacgtatta taactccgct ctcaaaagtc gcttgacgat aataaaagat     2640

aactccaaga gtcaagtttt ccttaaaatg aacagtttgc agactgacga taccgctata     2700

tattattgtg ctaaacatta ttactacggc ggtagttacg cgatggatta ttgggggcag     2760

gggacttctg tcacagtcag tagtgctgct gcctttgtcc cggtatttct cccagccaaa     2820

ccgaccacga ctcccgcccc gcgccctccg acacccgctc ccaccatcgc ctctcaacct     2880

cttagtcttc gccccgaggc atgccgaccc gccgccgggg gtgctgttca tacgaggggc     2940

ttggacttcg cttgtgatat ttacatttgg gctccgttgg cgggtacgtg cggcgtcctt     3000

ttgttgtcac tcgttattac tttgtattgt aatcacagga atcgctcaaa gcggagtagg     3060

ttgttgcatt ccgattacat gaatatgact cctcgccggc ctgggccgac aagaaaacat     3120

taccaaccct atgccccccc acgagacttc gctgcgtaca ggtcccgagt gaagttttcc     3180

cgaagcgcag acgctccggc atatcagcaa ggacagaatc agctgtataa cgaactgaat     3240

ttgggacgcc gcgaggagta tgacgtgctt gataaacgcc gggggagaga cccggaaatg     3300

gggggtaaac cccgaagaaa gaatccccaa gaaggactct acaatgaact ccagaaggat     3360

aagatggcgg aggcctactc agaaataggt atgaagggcg aacgacgacg gggaaaaggt     3420

cacgatggcc tctaccaagg gttgagtacg gcaaccaaag atacgtacga tgcactgcat     3480

atgcaggccc tgcctcccag ataataataa aatcgctatc catcgaagat ggatgtgtgt     3540

tggttttttg tgtgtggagc aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca     3600

gcattattcc agaagacacc ttcttcccca gcccaggtaa gggcagcttt ggtgccttcg     3660

caggctgttt ccttgcttca ggaatggcca ggttctgccc agagctctgg tcaatgatgt     3720

ctaaaactcc tctgattggt ggtctcggcc ttatccattg ccaccaaaac cctcttttta     3780

ctaagaaaca gtgagccttg ttctggcagt ccagagaatg acacgggaaa aaagcagatg     3840

aagagaaggt ggcaggagag ggcacgtggc ccagcctcag tctctccaac tgagttcctg     3900

cctgcctgcc tttgctcaga ctgtttgccc cttactgctc ttctaggcct cattctaagc     3960

cccttctcca agttgcctct ccttatttct ccctgtctgc caaaaaatct ttcccagctc     4020

actaagtcag tctcacgcag tcactcatta acccaccaat cactgattgt gccggcacat     4080

gaatgcacca ggtgttgaag tggaggaatt aaaaagtcag atgaggggtg tgcccagagg     4140

aagcaccatt ctagttgggg gagcccatct gtcagctggg aaaagtccaa ataacttcag     4200

attggaatgt gttttaactc agggttgaga aaacagctac cttcaggaca aaagtcaggg     4260

aagggctctc tgaagaaatg ctacttgaag ataccagccc taccaagggc agggagagga     4320

ccctatagag gcctgggaca ggagctcaat gagaaagg                             4358


<210>  55
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  56
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  57
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Lys Ile Leu Trp Phe Gly Glu Pro Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  58
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Lys Ile Leu Trp Phe Gly Glu Pro Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 


<210>  59
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  60
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Ser Phe Ala Met Ser 
1               5   


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Asp Lys Ile Leu Trp Phe Gly Glu Pro Val Phe Asp Tyr 
1               5                   10              


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Gln Gln Arg Ser Asn Trp Pro Pro Thr 
1               5                   


