                         SEQUENCE LISTING

<110>  BAYER AKTIENGESELLSCHAFT
       Bayer HealthCare LLC
       Bayer Intellectual Property GmbH
 
<120>  ANTIBODIES BINDING CHEMOKINE RECEPTORS

<130>  BHC201031; BHC201032; BHC201059; BHC211013; BHC211014

<160>  965   

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32246|CCR1_HUMAN_TRD

<400>  1

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro 
            20              


<210>  2
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q2Y2P0|CCR1_MACFA_TRD

<400>  2

Met Glu Thr Pro Asp Thr Thr Glu Asn Tyr Asp Met Ile Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro 
            20              


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51675|CCR1_MOUSE_TRD

<400>  3

Met Glu Ile Ser Asp Phe Thr Glu Ala Tyr Pro Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ser Thr Pro 
            20              


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32246|CCR1_HUMAN_N term


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Xaa Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala 
        


<210>  5
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q2Y2P0|CCR1_MACFA_N term


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Glu Thr Pro Asp Thr Thr Glu Asn Tyr Asp Met Ile Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Xaa His Lys Val Asn Glu Arg Ala Ile 
            20                  25                  30          


Leu Ala 
        


<210>  6
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51675|CCR1_MOUSE_N term


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Met Glu Ile Ser Asp Phe Thr Glu Ala Tyr Pro Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ser Thr Pro Xaa Gln Lys Thr Ala Val Arg Ala Phe 
            20                  25                  30          


Gly Ala 
        


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P41597|CCR2_HUMAN_TRD

<400>  7

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O18793|CCR2_MACMU_TRD

<400>  8

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Gly Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro 
            20                  25                  30      


<210>  9
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51683|CCR2_MOUSE_TRD

<400>  9

Met Glu Asp Asn Asn Met Leu Pro Gln Phe Ile His Gly Ile Leu Ser 
1               5                   10                  15      


Thr Ser His Ser Leu Phe Thr Arg Ser Ile Gln Glu Leu Asp Glu Gly 
            20                  25                  30          


Ala Thr Thr Pro Tyr Asp Tyr Asp Asp Gly Glu Pro 
        35                  40                  


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P41597|CCR2_HUMAN_N term


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Xaa 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala 
        35                  40          


<210>  11
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O18793|CCR2_MACMU_N term


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Gly Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Xaa 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala 
        35                  40          


<210>  12
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51683|CCR2_MOUSE_N term


<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Met Glu Asp Asn Asn Met Leu Pro Gln Phe Ile His Gly Ile Leu Ser 
1               5                   10                  15      


Thr Ser His Ser Leu Phe Thr Arg Ser Ile Gln Glu Leu Asp Glu Gly 
            20                  25                  30          


Ala Thr Thr Pro Tyr Asp Tyr Asp Asp Gly Glu Pro Xaa His Lys Thr 
        35                  40                  45              


Ser Val Lys Gln Ile Gly Ala 
    50                  55  


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51677|CCR3_HUMAN_TRD

<400>  13

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu 
            20              


<210>  14
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9BDS8|CCR3_MACFA_TRD

<400>  14

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Pro Thr Ser Tyr 
1               5                   10                  15      


Asp Asp Asp Met Gly Leu Leu 
            20              


<210>  15
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51678|CCR3_MOUSE_TRD

<400>  15

Met Ala Phe Asn Thr Asp Glu Ile Lys Thr Val Val Glu Ser Phe Glu 
1               5                   10                  15      


Thr Thr Pro Tyr Glu Tyr Glu Trp Ala Pro Pro 
            20                  25          


<210>  16
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51677|CCR3_HUMAN_N term


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Xaa Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala 
        


<210>  17
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9BDS8|CCR3_MACFA_N term


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Pro Thr Ser Tyr 
1               5                   10                  15      


Asp Asp Asp Met Gly Leu Leu Xaa Glu Lys Ala Asp Val Gly Ala Leu 
            20                  25                  30          


Ile Ala 
        


<210>  18
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51678|CCR3_MOUSE_N term


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Met Ala Phe Asn Thr Asp Glu Ile Lys Thr Val Val Glu Ser Phe Glu 
1               5                   10                  15      


Thr Thr Pro Tyr Glu Tyr Glu Trp Ala Pro Pro Xaa Glu Lys Val Arg 
            20                  25                  30          


Ile Lys Glu Leu Gly Ser 
        35              


<210>  19
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51679|CCR4_HUMAN_TRD

<400>  19

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro 
            20                  25              


<210>  20
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|G7NYB7|CCR4_MACFA_TRD

<400>  20

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro 
            20                  25              


<210>  21
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51680|CCR4_MOUSE_TRD

<400>  21

Met Asn Ala Thr Glu Val Thr Asp Thr Thr Gln Asp Glu Thr Val Tyr 
1               5                   10                  15      


Asn Ser Tyr Tyr Phe Tyr Glu Ser Met Pro Lys Pro 
            20                  25              


<210>  22
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51679|CCR4_HUMAN_N term


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Xaa Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu 
        35                  


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|G7NYB7|CCR4_MACFA_N term


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Xaa Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu 
        35                  


<210>  24
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51680|CCR4_MOUSE_N term


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Met Asn Ala Thr Glu Val Thr Asp Thr Thr Gln Asp Glu Thr Val Tyr 
1               5                   10                  15      


Asn Ser Tyr Tyr Phe Tyr Glu Ser Met Pro Lys Pro Xaa Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu 
        35                  


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51681|CCR5_HUMAN_TRD

<400>  25

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro 
            


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P61814|CCR5_MACFA_TRD

<400>  26

Met Asp Tyr Gln Val Ser Ser Pro Thr Tyr Asp Ile Asp Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro 
            


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51682|CCR5_MOUSE_TRD

<400>  27

Met Asp Phe Gln Gly Ser Val Pro Thr Tyr Ser Tyr Asp Ile Asp Tyr 
1               5                   10                  15      


Gly Met Ser Ala Pro 
            20      


<210>  28
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51681|CCR5_HUMAN_N term


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Xaa Gln Lys Ile Asn Val Lys Gln Ile Ala Ala 
            20                  25                  30  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P61814|CCR5_MACFA_N term


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Met Asp Tyr Gln Val Ser Ser Pro Thr Tyr Asp Ile Asp Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Xaa Gln Lys Ile Asn Val Lys Gln Ile Ala Ala 
            20                  25                  30  


<210>  30
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51682|CCR5_MOUSE_N term


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Met Asp Phe Gln Gly Ser Val Pro Thr Tyr Ser Tyr Asp Ile Asp Tyr 
1               5                   10                  15      


Gly Met Ser Ala Pro Xaa Gln Lys Ile Asn Val Lys Gln Ile Ala Ala 
            20                  25                  30          


<210>  31
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51684|CCR6_HUMAN_TRD

<400>  31

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu 
        35  


<210>  32
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5WY45|CCR6_MACFA_TRD

<400>  32

Met Phe Leu Pro Thr Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val 
1               5                   10                  15      


Phe Asp Ser Ser Glu Asp Tyr Phe Ala Ser Val Asn Thr Ser Tyr Tyr 
            20                  25                  30          


Thr Val Asp Ser Glu Met Leu Leu 
        35                  40  


<210>  33
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O54689|CCR6_MOUSE_TRD

<400>  33

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro 
            20                  25          


<210>  34
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51684|CCR6_HUMAN_N term


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Xaa Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu 
        35                  40                  45          


<210>  35
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5WY45|CCR6_MACFA_N term


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Met Phe Leu Pro Thr Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val 
1               5                   10                  15      


Phe Asp Ser Ser Glu Asp Tyr Phe Ala Ser Val Asn Thr Ser Tyr Tyr 
            20                  25                  30          


Thr Val Asp Ser Glu Met Leu Leu Xaa Thr Leu His Glu Val Arg Gln 
        35                  40                  45              


Phe Ser Arg Leu 
    50          


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O54689|CCR6_MOUSE_N term


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro Xaa Ser Leu Glu Glu 
            20                  25                  30          


Val Arg Asn Phe Thr Lys Val 
        35                  


<210>  37
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32248|CCR7_HUMAN_TRD

<400>  37

Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Phe Glu Ser Leu 
            20              


<210>  38
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|C0ISS3|CCR7_MACFA_TRD

<400>  38

Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Phe Glu Ser Leu 
            20              


<210>  39
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P47774|CCR7_MOUSE_TRD

<400>  39

Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Glu Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Tyr Glu Ser Val 
            20              


<210>  40
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32248|CCR7_HUMAN_N term (w/o Signal Peptide))


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Phe Glu Ser Leu Xaa Ser Lys Lys Asp Val Arg Asn Phe 
            20                  25                  30          


Lys Ala Trp 
        35  


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|C0ISS3|CCR7_MACFA_N term (w/o  Signal Peptide))


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Phe Glu Ser Leu Xaa Ser Lys Lys Asp Val Arg Asn Phe 
            20                  25                  30          


Lys Ala Trp 
        35  


<210>  42
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P47774|CCR7_MOUSE_N term (w/o  Signal Peptide))


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Glu Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Tyr Glu Ser Val Xaa Phe Lys Lys Asp Val Arg Asn Phe 
            20                  25                  30          


Lys Ala Trp 
        35  


<210>  43
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51685|CCR8_HUMAN_TRD

<400>  43

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro 
            20                  


<210>  44
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|G7NYJ2|CCR8_MACFA_TRD

<400>  44

Met Asp Tyr Thr Leu Asp Pro Ser Met Thr Thr Met Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Ser Ser Pro 
            20                  


<210>  45
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P56484|CCR8_MOUSE_TRD

<400>  45

Met Asp Tyr Thr Met Glu Pro Asn Val Thr Met Thr Asp Tyr Tyr Pro 
1               5                   10                  15      


Asp Phe Phe Thr Ala Pro 
            20          


<210>  46
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51685|CCR8_HUMAN_N term


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Xaa Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys 
        35  


<210>  47
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|G7NYJ2|CCR8_MACFA_N term


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Met Asp Tyr Thr Leu Asp Pro Ser Met Thr Thr Met Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Ser Ser Pro Xaa Asp Gly Glu Leu Ile Gln Arg 
            20                  25                  30          


Asn Asp Lys 
        35  


<210>  48
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P56484|CCR8_MOUSE_N term


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Met Asp Tyr Thr Met Glu Pro Asn Val Thr Met Thr Asp Tyr Tyr Pro 
1               5                   10                  15      


Asp Phe Phe Thr Ala Pro Xaa Asp Ala Glu Phe Leu Leu Arg Gly Ser 
            20                  25                  30          


Met 
    


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51685|CCR8_HUMAN_LID

<400>  49

Asp Ala Glu Leu Ile Gln Thr Asn Gly Lys 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|G7NYJ2|CCR8_MACFA_LID

<400>  50

Asp Gly Glu Leu Ile Gln Arg Asn Asp Lys 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P56484|CCR8_MOUSE_LID

<400>  51

Asp Ala Glu Phe Leu Leu Arg Gly Ser Met 
1               5                   10  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51685|CCR8_HUMAN_ECL1

<400>  52

Tyr Leu Leu Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys 
1               5                   10                  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|G7NYJ2|CCR8_MACFA_ECL1

<400>  53

Tyr Gln Leu Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P56484|CCR8_MOUSE_ECL1

<400>  54

Asn Leu Leu Asp Gln Trp Val Phe Gly Thr Ala Met Cys Lys 
1               5                   10                  


<210>  55
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51685|CCR8_HUMAN_ECL2

<400>  55

Tyr Gln Val Ala Ser Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr 
1               5                   10                  15      


Asn Gln Gln Thr Leu Lys Trp Lys Ile Phe Thr Asn Phe Lys Met 
            20                  25                  30      


<210>  56
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|G7NYJ2|CCR8_MACFA_ECL2

<400>  56

Tyr Gln Val Ala Ser Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr 
1               5                   10                  15      


Asn Gln Gln Thr Leu Lys Trp Lys Ile Phe Thr Asn Phe Glu Met 
            20                  25                  30      


<210>  57
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P56484|CCR8_MOUSE_ECL2

<400>  57

Tyr Gln Val Ala Ser Glu Asp Gly Met Leu Gln Cys Phe Gln Phe Tyr 
1               5                   10                  15      


Glu Glu Gln Ser Leu Arg Trp Lys Leu Phe Thr His Phe Glu Ile 
            20                  25                  30      


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51685|CCR8_HUMAN_ECL3

<400>  58

His Ser Met His Ile Leu Asp Gly Cys Ser Ile Ser Gln Gln Leu Thr 
1               5                   10                  15      


Tyr 
    


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|G7NYJ2|CCR8_MACFA_ECL3

<400>  59

His Ser Met His Ile Leu Asp Gly Cys Ser Ile Ser Gln Gln Leu Asn 
1               5                   10                  15      


Tyr 
    


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P56484|CCR8_MOUSE_ECL3

<400>  60

His Asp Leu His Ile Leu Asp Gly Cys Ala Thr Arg Gln Arg Leu Ala 
1               5                   10                  15      


Leu 
    


<210>  61
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51686|CCR9_HUMAN_TRD

<400>  61

Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr 
        35          


<210>  62
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|Q0H741|CCR9_MACFA_TRD

<400>  62

Met Thr Pro Thr Glu Phe Thr Ser Pro Val Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr 
        35          


<210>  63
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9WUT7|CCR9_MOUSE_TRD

<400>  63

Met Thr Pro Thr Glu Phe Thr Ser Pro Val Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr 
        35          


<210>  64
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51686|CCR9_HUMAN_N term


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  64

Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Xaa Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


<210>  65
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|Q0H741|CCR9_MACFA_N term


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  65

Met Thr Pro Thr Glu Phe Thr Ser Pro Val Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Xaa Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


<210>  66
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9WUT7|CCR9_MOUSE_N term


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  66

Met Thr Pro Thr Glu Phe Thr Ser Pro Val Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Xaa Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


<210>  67
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P46092|CCR10_HUMAN_TRD

<400>  67

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu 
            20                  25                  30  


<210>  68
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5UAP1|CCR10_MACFA_TRD

<400>  68

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Glu Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu 
            20                  25                  30  


<210>  69
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9JL21|CCR10_MOUSE_TRD

<400>  69

Met Gly Thr Lys Pro Thr Glu Gln Val Ser Trp Gly Leu Tyr Ser Gly 
1               5                   10                  15      


Tyr Asp Glu Glu Ala Tyr Ser Val Gly Pro Leu Pro Glu Leu 
            20                  25                  30  


<210>  70
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P46092|CCR10_HUMAN_N term


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  70

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Xaa Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala 
    50          


<210>  71
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5UAP1|CCR10_MACFA_N term


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  71

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Glu Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Xaa Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala 
    50          


<210>  72
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9JL21|CCR10_MOUSE_N term


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  72

Met Gly Thr Lys Pro Thr Glu Gln Val Ser Trp Gly Leu Tyr Ser Gly 
1               5                   10                  15      


Tyr Asp Glu Glu Ala Tyr Ser Val Gly Pro Leu Pro Glu Leu Xaa Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25024|CXCR1_HUMAN_TRD

<400>  73

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro 
            20                  25                  


<210>  74
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5X9E4|CXCR1_MACFA_TRD

<400>  74

Met Ser Asn Ala Thr Asp Pro Gln Met Gly Asp Asp Asp Tyr Asp Leu 
1               5                   10                  15      


Asn Phe Thr Gly Met Pro Pro Thr Asp Glu Asp Tyr Ser Pro 
            20                  25                  30  


<210>  75
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q810W6|CXCR1_MOUSE_TRD

<400>  75

Met Ala Glu Ala Glu Tyr Phe Ile Trp Thr Asn Pro Glu Gly Asp Phe 
1               5                   10                  15      


Glu Lys Glu Phe Gly Asn Ile Thr Gly Met Leu Pro Thr Gly Asp Tyr 
            20                  25                  30          


Phe Ile Pro 
        35  


<210>  76
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25024|CXCR1_HUMAN_N term


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  76

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Xaa Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys 
        35                  


<210>  77
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5X9E4|CXCR1_MACFA_N term


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Met Ser Asn Ala Thr Asp Pro Gln Met Gly Asp Asp Asp Tyr Asp Leu 
1               5                   10                  15      


Asn Phe Thr Gly Met Pro Pro Thr Asp Glu Asp Tyr Ser Pro Xaa Arg 
            20                  25                  30          


Leu Glu Thr Gln Ser Leu Asn Lys 
        35                  40  


<210>  78
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q810W6|CXCR1_MOUSE_N term


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<400>  78

Met Ala Glu Ala Glu Tyr Phe Ile Trp Thr Asn Pro Glu Gly Asp Phe 
1               5                   10                  15      


Glu Lys Glu Phe Gly Asn Ile Thr Gly Met Leu Pro Thr Gly Asp Tyr 
            20                  25                  30          


Phe Ile Pro Xaa Lys Arg Val Pro Ile Thr Asn Arg 
        35                  40                  


<210>  79
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25025|CXCR2_HUMAN_TRD

<400>  79

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro 
        35              


<210>  80
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q28519|CXCR2_MACMU_TRD

<400>  80

Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Leu Trp Lys Gly Glu Asp 
1               5                   10                  15      


Phe Ser Asn Tyr Ser Tyr Ser Ser Asp Leu Pro Pro Ser Leu Pro Asp 
            20                  25                  30          


Val Ala Pro 
        35  


<210>  81
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P35343|CXCR2_MOUSE_TRD

<400>  81

Met Gly Glu Phe Lys Val Asp Lys Phe Asn Ile Glu Asp Phe Phe Ser 
1               5                   10                  15      


Gly Asp Leu Asp Ile Phe Asn Tyr Ser Ser Gly Met Pro Ser Ile Leu 
            20                  25                  30          


Pro Asp Ala Val Pro 
        35          


<210>  82
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25025|CXCR2_HUMAN_N term


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  82

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Xaa Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


<210>  83
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q28519|CXCR2_MACMU_N term


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<400>  83

Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Leu Trp Lys Gly Glu Asp 
1               5                   10                  15      


Phe Ser Asn Tyr Ser Tyr Ser Ser Asp Leu Pro Pro Ser Leu Pro Asp 
            20                  25                  30          


Val Ala Pro Xaa Arg Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45  


<210>  84
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P35343|CXCR2_MOUSE_N term


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  84

Met Gly Glu Phe Lys Val Asp Lys Phe Asn Ile Glu Asp Phe Phe Ser 
1               5                   10                  15      


Gly Asp Leu Asp Ile Phe Asn Tyr Ser Ser Gly Met Pro Ser Ile Leu 
            20                  25                  30          


Pro Asp Ala Val Pro Xaa His Ser Glu Asn Leu Glu Ile Asn Ser 
        35                  40                  45          


<210>  85
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P49682|CXCR3_HUMAN_TRD

<400>  85

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser 
        35      


<210>  86
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5UV19|CXCR3_MACFA_TRD

<400>  86

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser 
        35      


<210>  87
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O88410|CXCR3_MOUSE_TRD

<400>  87

Met Tyr Leu Glu Val Ser Glu Arg Gln Val Leu Asp Ala Ser Asp Phe 
1               5                   10                  15      


Ala Phe Leu Leu Glu Asn Ser Thr Ser Pro Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Phe Ser Asp Ser Pro Pro 
        35                  40      


<210>  88
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P49682|CXCR3_HUMAN_N term


<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  88

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Xaa Xaa Thr Ser Pro Pro 
        35                  40          


<210>  89
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5UV19|CXCR3_MACFA_N term


<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  89

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Xaa Xaa Thr Ser Pro Pro 
        35                  40          


<210>  90
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O88410|CXCR3_MOUSE_N term


<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa can be any naturally occurring amino acid

<400>  90

Met Tyr Leu Glu Val Ser Glu Arg Gln Val Leu Asp Ala Ser Asp Phe 
1               5                   10                  15      


Ala Phe Leu Leu Glu Asn Ser Thr Ser Pro Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Phe Ser Asp Ser Pro Pro Xaa Pro Gln Asp Phe Ser Leu 
        35                  40                  45              


Asn Phe Asp Arg 
    50          


<210>  91
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P61073|CXCR4_HUMAN_TRD

<400>  91

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro 
            20                  25          


<210>  92
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q28474|CXCR4_MACFA_TRD

<400>  92

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Ile Lys Glu Pro 
            20                  25          


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P70658|CXCR4_MOUSE_TRD

<400>  93

Met Glu Pro Ile Ser Val Ser Ile Tyr Thr Ser Asp Asn Tyr Ser Glu 
1               5                   10                  15      


Glu Val Gly Ser Gly Asp Tyr Asp Ser Asn Lys Glu Pro 
            20                  25                  


<210>  94
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P61073|CXCR4_HUMAN_N term


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  94

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Xaa Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys 
        35              


<210>  95
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q28474|CXCR4_MACFA_N term


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  95

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Ile Lys Glu Pro Xaa Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala His Phe Asn Arg 
        35              


<210>  96
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P70658|CXCR4_MOUSE_N term


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  96

Met Glu Pro Ile Ser Val Ser Ile Tyr Thr Ser Asp Asn Tyr Ser Glu 
1               5                   10                  15      


Glu Val Gly Ser Gly Asp Tyr Asp Ser Asn Lys Glu Pro Xaa Phe Arg 
            20                  25                  30          


Asp Glu Asn Val His Phe Asn Arg 
        35                  40  


<210>  97
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32302|CXCR5_HUMAN_TRD

<400>  97

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu 
        35          


<210>  98
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|G8F5K4|CXCR5_MACFA_TRD

<400>  98

Met Asn Tyr Pro Leu Met Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Leu Glu Phe Asp Lys Phe Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu 
        35          


<210>  99
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q04683|CXCR5_MOUSE_TRD

<400>  99

Met Asn Tyr Pro Leu Thr Leu Asp Met Gly Ser Ile Thr Tyr Asn Met 
1               5                   10                  15      


Asp Asp Leu Tyr Lys Glu Leu Ala Phe Tyr Ser Asn Ser Thr Glu Ile 
            20                  25                  30          


Pro Leu Gln Asp Ser Asn Phe 
        35                  


<210>  100
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32302|CXCR5_HUMAN_N term


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  100

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Xaa Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro 
    50                  55  


<210>  101
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|G8F5K4|CXCR5_MACFA_N term


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  101

Met Asn Tyr Pro Leu Met Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Leu Glu Phe Asp Lys Phe Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Xaa Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro 
    50                  55  


<210>  102
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q04683|CXCR5_MOUSE_N term


<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<400>  102

Met Asn Tyr Pro Leu Thr Leu Asp Met Gly Ser Ile Thr Tyr Asn Met 
1               5                   10                  15      


Asp Asp Leu Tyr Lys Glu Leu Ala Phe Tyr Ser Asn Ser Thr Glu Ile 
            20                  25                  30          


Pro Leu Gln Asp Ser Asn Phe Xaa Ser Thr Val Glu Gly Pro Leu Leu 
        35                  40                  45              


Thr Ser Phe Lys Ala Val Phe Met Pro 
    50                  55          


<210>  103
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O00574|CXCR6_HUMAN_TRD

<400>  103

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


<210>  104
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9BDS6|CXCR6_MACFA_TRD

<400>  104

Met Ala Glu Tyr Asp His Tyr Glu Asp Asp Gly Phe Leu Asn Ser Phe 
1               5                   10                  15      


Asn Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Arg Lys 
            20                  25                  30          


Val 
    


<210>  105
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9EQ16|CXCR6_MOUSE_TRD

<400>  105

Met Asp Asp Gly His Gln Glu Ser Ala Leu Tyr Asp Gly His Tyr Glu 
1               5                   10                  15      


Gly Asp Phe Trp Leu Phe Asn Asn Ser Ser Asp Asn Ser Gln Glu Asn 
            20                  25                  30          


Lys Arg Phe Leu Lys Phe Lys Glu Val 
        35                  40      


<210>  106
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O00574|CXCR6_HUMAN_N term


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<400>  106

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Xaa Met Tyr Leu Val Val Phe Val 
        35                  40              


<210>  107
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9BDS6|CXCR6_MACFA_N term


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<400>  107

Met Ala Glu Tyr Asp His Tyr Glu Asp Asp Gly Phe Leu Asn Ser Phe 
1               5                   10                  15      


Asn Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Arg Lys 
            20                  25                  30          


Val Phe Leu Pro Xaa Met Tyr Leu Val Val Phe Val 
        35                  40                  


<210>  108
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9EQ16|CXCR6_MOUSE_N term


<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<400>  108

Met Asp Asp Gly His Gln Glu Ser Ala Leu Tyr Asp Gly His Tyr Glu 
1               5                   10                  15      


Gly Asp Phe Trp Leu Phe Asn Asn Ser Ser Asp Asn Ser Gln Glu Asn 
            20                  25                  30          


Lys Arg Phe Leu Lys Phe Lys Glu Val Phe Leu Pro Xaa 
        35                  40                  45  


<210>  109
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32246|CCR1_HUMAN

<400>  109

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  110
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q2Y2P0|CCR1_MACFA

<400>  110

Met Glu Thr Pro Asp Thr Thr Glu Asn Tyr Asp Met Ile Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys His Lys Val Asn Glu Arg Ala Ile 
            20                  25                  30          


Leu Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Val Val Gly Asn Leu Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Leu Ile Tyr Tyr Lys Ser Thr 
                85                  90                  95      


Asp Asp Trp Ile Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Ser Pro Leu Met Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Asn Ile Val Arg His Ser Cys Asn Leu His Phe Pro Tyr Glu Ser Phe 
            180                 185                 190         


Gln Gln Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Val Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Glu Leu Ile Ser Val Phe Gln Glu Phe Leu Phe Thr His Leu 
            260                 265                 270         


Cys Glu Gln Asn Arg Gln Leu Asp Leu Ala Met Glu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Asn Met His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Ala 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Gly Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Leu 
        355 


<210>  111
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51675|CCR1_MOUSE

<400>  111

Met Glu Ile Ser Asp Phe Thr Glu Ala Tyr Pro Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ser Thr Pro Cys Gln Lys Thr Ala Val Arg Ala Phe 
            20                  25                  30          


Gly Ala Gly Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Ile Gly 
        35                  40                  45              


Val Val Gly Asn Val Leu Val Ile Leu Val Leu Met Gln His Arg Arg 
    50                  55                  60                  


Leu Gln Ser Met Thr Ser Ile Tyr Leu Phe Asn Leu Ala Val Ser Asp 
65                  70                  75                  80  


Leu Val Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Ile Phe Gly Asp Ala Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Leu Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Ile Ile Thr Ser Ile Ile Thr Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Ala Leu Tyr Phe Phe Lys Ala Gln Trp 
                165                 170                 175     


Glu Phe Thr His Arg Thr Cys Ser Pro His Phe Pro Tyr Lys Ser Leu 
            180                 185                 190         


Lys Gln Trp Lys Arg Phe Gln Ala Leu Lys Leu Asn Leu Leu Gly Leu 
        195                 200                 205             


Ile Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Ala Gly Ile Ile Arg 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Ser Glu Lys Lys Val Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Ala Ile Thr Leu Leu Phe Phe Leu Leu Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Ser Val Phe Val Ser Ala Phe Gln Asp Val Leu Phe Thr Asn Gln 
            260                 265                 270         


Cys Glu Gln Ser Lys Gln Leu Asp Leu Ala Met Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Ile Ile Tyr Val Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Trp Lys Tyr Leu Arg Gln Leu Phe Gln Arg His Val 
305                 310                 315                 320 


Ala Ile Pro Leu Ala Lys Trp Leu Pro Phe Leu Ser Val Asp Gln Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Ile Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  112
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P41597|CCR2_HUMAN

<400>  112

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  113
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O18793|CCR2_MACMU

<400>  113

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Gly Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Ser Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Leu Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Glu Glu Asp Ser Val Tyr Ile Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Leu Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Arg Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Arg Tyr Leu Ser Met Phe Phe 
305                 310                 315                 320 


Arg Lys Tyr Ile Thr Lys Arg Phe Cys Lys Gln Cys Pro Val Phe Tyr 
                325                 330                 335     


Arg Glu Thr Val Asp Gly Val Thr Ser Thr Asn Thr Pro Ser Thr Ala 
            340                 345                 350         


Glu Gln Glu Val Ser Val Gly Leu 
        355                 360 


<210>  114
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51683|CCR2_MOUSE

<400>  114

Met Glu Asp Asn Asn Met Leu Pro Gln Phe Ile His Gly Ile Leu Ser 
1               5                   10                  15      


Thr Ser His Ser Leu Phe Thr Arg Ser Ile Gln Glu Leu Asp Glu Gly 
            20                  25                  30          


Ala Thr Thr Pro Tyr Asp Tyr Asp Asp Gly Glu Pro Cys His Lys Thr 
        35                  40                  45              


Ser Val Lys Gln Ile Gly Ala Trp Ile Leu Pro Pro Leu Tyr Ser Leu 
    50                  55                  60                  


Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Ile Ile Ile Leu 
65                  70                  75                  80  


Ile Gly Cys Lys Lys Leu Lys Ser Met Thr Asp Ile Tyr Leu Leu Asn 
                85                  90                  95      


Leu Ala Ile Ser Asp Leu Leu Phe Leu Leu Thr Leu Pro Phe Trp Ala 
            100                 105                 110         


His Tyr Ala Ala Asn Glu Trp Val Phe Gly Asn Ile Met Cys Lys Val 
        115                 120                 125             


Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile Phe Phe Ile 
    130                 135                 140                 


Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
145                 150                 155                 160 


Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Val Val 
                165                 170                 175     


Thr Trp Val Val Ala Val Phe Ala Ser Leu Pro Gly Ile Ile Phe Thr 
            180                 185                 190         


Lys Ser Lys Gln Asp Asp His His Tyr Thr Cys Gly Pro Tyr Phe Thr 
        195                 200                 205             


Gln Leu Trp Lys Asn Phe Gln Thr Ile Met Arg Asn Ile Leu Ser Leu 
    210                 215                 220                 


Ile Leu Pro Leu Leu Val Met Val Ile Cys Tyr Ser Gly Ile Leu His 
225                 230                 235                 240 


Thr Leu Phe Arg Cys Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg 
                245                 250                 255     


Leu Ile Phe Ala Ile Met Ile Val Tyr Phe Leu Phe Trp Thr Pro Tyr 
            260                 265                 270         


Asn Ile Val Leu Phe Leu Thr Thr Phe Gln Glu Ser Leu Gly Met Ser 
        275                 280                 285             


Asn Cys Val Ile Asp Lys His Leu Asp Gln Ala Met Gln Val Thr Glu 
    290                 295                 300                 


Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Val Ile Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Glu Lys Phe Arg Arg Tyr Leu Ser Ile Phe Phe Arg Lys His 
                325                 330                 335     


Ile Ala Lys Arg Leu Cys Lys Gln Cys Pro Val Phe Tyr Arg Glu Thr 
            340                 345                 350         


Ala Asp Arg Val Ser Ser Thr Phe Thr Pro Ser Thr Gly Glu Gln Glu 
        355                 360                 365             


Val Ser Val Gly Leu 
    370             


<210>  115
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51677|CCR3_HUMAN

<400>  115

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly 
                85                  90                  95      


His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu 
                165                 170                 175     


Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu 
305                 310                 315                 320 


Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210>  116
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9BDS8|CCR3_MACFA

<400>  116

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Pro Thr Ser Tyr 
1               5                   10                  15      


Asp Asp Asp Met Gly Leu Leu Cys Glu Lys Ala Asp Val Gly Ala Leu 
            20                  25                  30          


Ile Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Met Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile His Tyr Val Arg Glu 
                85                  90                  95      


Arg Asn Trp Val Phe Ser His Gly Met Cys Lys Val Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Val Thr Ser Ile Val Thr Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Gly Thr Glu Glu 
                165                 170                 175     


Leu Phe Pro Glu Thr Leu Cys Ser Ala Ile Tyr Pro Gln Asp Thr Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Leu Cys Leu 
        195                 200                 205             


Ala Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Ile Ser Thr Tyr Gln Ser Ile Leu Phe Gly Pro Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Phe Val Leu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Trp Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Val 
305                 310                 315                 320 


Leu Met His Pro Gly Lys Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210>  117
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51678|CCR3_MOUSE

<400>  117

Met Ala Phe Asn Thr Asp Glu Ile Lys Thr Val Val Glu Ser Phe Glu 
1               5                   10                  15      


Thr Thr Pro Tyr Glu Tyr Glu Trp Ala Pro Pro Cys Glu Lys Val Arg 
            20                  25                  30          


Ile Lys Glu Leu Gly Ser Trp Leu Leu Pro Pro Leu Tyr Ser Leu Val 
        35                  40                  45              


Phe Ile Ile Gly Leu Leu Gly Asn Met Met Val Val Leu Ile Leu Ile 
    50                  55                  60                  


Lys Tyr Arg Lys Leu Gln Ile Met Thr Asn Ile Tyr Leu Phe Asn Leu 
65                  70                  75                  80  


Ala Ile Ser Asp Leu Leu Phe Leu Phe Thr Val Pro Phe Trp Ile His 
                85                  90                  95      


Tyr Val Leu Trp Asn Glu Trp Gly Phe Gly His Tyr Met Cys Lys Met 
            100                 105                 110         


Leu Ser Gly Phe Tyr Tyr Leu Ala Leu Tyr Ser Glu Ile Phe Phe Ile 
        115                 120                 125             


Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ala Leu Arg Ala Arg Thr Val Thr Phe Ala Thr Ile Thr Ser Ile Ile 
145                 150                 155                 160 


Thr Trp Gly Leu Ala Gly Leu Ala Ala Leu Pro Glu Phe Ile Phe His 
                165                 170                 175     


Glu Ser Gln Asp Ser Phe Gly Glu Phe Ser Cys Ser Pro Arg Tyr Pro 
            180                 185                 190         


Glu Gly Glu Glu Asp Ser Trp Lys Arg Phe His Ala Leu Arg Met Asn 
        195                 200                 205             


Ile Phe Gly Leu Ala Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser 
    210                 215                 220                 


Gly Ile Ile Lys Thr Leu Leu Arg Cys Pro Asn Lys Lys Lys His Lys 
225                 230                 235                 240 


Ala Ile Arg Leu Ile Phe Val Val Met Ile Val Phe Phe Ile Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Leu Val Leu Leu Phe Ser Ala Phe His Ser Thr Phe 
            260                 265                 270         


Leu Glu Thr Ser Cys Gln Gln Ser Lys His Leu Asp Leu Ala Met Gln 
        275                 280                 285             


Val Thr Glu Val Ile Ala Tyr Thr His Cys Cys Ile Asn Pro Val Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Arg Phe Arg Lys His Leu Arg Leu Phe Phe 
305                 310                 315                 320 


His Arg Asn Val Ala Val Tyr Leu Gly Lys Tyr Ile Pro Phe Leu Pro 
                325                 330                 335     


Gly Glu Lys Met Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Gly Glu 
            340                 345                 350         


Gln Glu Ile Ser Val Val Phe 
        355                 


<210>  118
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51679|CCR4_HUMAN

<400>  118

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  119
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|G7NYB7|CCR4_MACFA

<400>  119

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Ile Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Ile Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Phe Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Asp Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Phe Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  120
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51680|CCR4_MOUSE

<400>  120

Met Asn Ala Thr Glu Val Thr Asp Thr Thr Gln Asp Glu Thr Val Tyr 
1               5                   10                  15      


Asn Ser Tyr Tyr Phe Tyr Glu Ser Met Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Val Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Leu Leu Gly Leu Phe Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Lys Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Leu Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Ile 
            100                 105                 110         


Val Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Ile 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Lys Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ile 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Leu Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu His Asn His Thr Tyr Cys Lys Thr Gln Tyr Ser 
            180                 185                 190         


Val Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Val 
        195                 200                 205             


Leu Gly Leu Leu Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Arg Ala 
225                 230                 235                 240 


Val Arg Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Val Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Leu Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Ile His Cys Cys Leu Asn Pro Val Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Thr Gln Leu Phe Arg 
305                 310                 315                 320 


Thr Cys Arg Gly Pro Leu Val Leu Cys Lys His Cys Asp Phe Leu Gln 
                325                 330                 335     


Val Tyr Ser Ala Asp Met Ser Ser Ser Ser Tyr Thr Gln Ser Thr Val 
            340                 345                 350         


Asp His Asp Phe Arg Asp Ala Leu 
        355                 360 


<210>  121
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51681|CCR5_HUMAN

<400>  121

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  122
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P61814|CCR5_MACFA

<400>  122

Met Asp Tyr Gln Val Ser Ser Pro Thr Tyr Asp Ile Asp Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Ile Leu Val Val Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Arg Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Met Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  123
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51682|CCR5_MOUSE

<400>  123

Met Asp Phe Gln Gly Ser Val Pro Thr Tyr Ser Tyr Asp Ile Asp Tyr 
1               5                   10                  15      


Gly Met Ser Ala Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala 
            20                  25                  30          


Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val 
        35                  40                  45              


Gly Asn Met Met Val Phe Leu Ile Leu Ile Ser Cys Lys Lys Leu Lys 
    50                  55                  60                  


Ser Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu 
65                  70                  75                  80  


Phe Leu Leu Thr Leu Pro Phe Trp Ala His Tyr Ala Ala Asn Glu Trp 
                85                  90                  95      


Val Phe Gly Asn Ile Met Cys Lys Val Phe Thr Gly Leu Tyr His Ile 
            100                 105                 110         


Gly Tyr Phe Gly Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg 
        115                 120                 125             


Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Lys Val Arg Thr Val 
    130                 135                 140                 


Asn Phe Gly Val Ile Thr Ser Val Val Thr Trp Ala Val Ala Val Phe 
145                 150                 155                 160 


Ala Ser Leu Pro Glu Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Phe 
                165                 170                 175     


His Tyr Thr Cys Ser Pro His Phe Pro His Thr Gln Tyr His Phe Trp 
            180                 185                 190         


Lys Ser Phe Gln Thr Leu Lys Met Val Ile Leu Ser Leu Ile Leu Pro 
        195                 200                 205             


Leu Leu Val Met Val Ile Cys Tyr Ser Gly Ile Leu His Thr Leu Phe 
    210                 215                 220                 


Arg Cys Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Met Ile Val Tyr Phe Leu Phe Trp Thr Pro Tyr Asn Ile Val 
                245                 250                 255     


Leu Leu Leu Thr Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser 
            260                 265                 270         


Ser Ser Asn Arg Leu Asp Gln Ala Met Gln Ala Thr Glu Thr Leu Gly 
        275                 280                 285             


Met Thr His Cys Cys Leu Asn Pro Val Ile Tyr Ala Phe Val Gly Glu 
    290                 295                 300                 


Lys Phe Arg Ser Tyr Leu Ser Val Phe Phe Arg Lys His Met Val Lys 
305                 310                 315                 320 


Arg Phe Cys Lys Arg Cys Ser Ile Phe Gln Gln Asp Asn Pro Asp Arg 
                325                 330                 335     


Ala Ser Ser Val Tyr Thr Arg Ser Thr Gly Glu His Glu Val Ser Thr 
            340                 345                 350         


Gly Leu 
        


<210>  124
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51684|CCR6_HUMAN

<400>  124

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  125
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5WY45|CCR6_MACFA

<400>  125

Met Phe Leu Pro Thr Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val 
1               5                   10                  15      


Phe Asp Ser Ser Glu Asp Tyr Phe Ala Ser Val Asn Thr Ser Tyr Tyr 
            20                  25                  30          


Thr Val Asp Ser Glu Met Leu Leu Cys Thr Leu His Glu Val Arg Gln 
        35                  40                  45              


Phe Ser Arg Leu Phe Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe 
    50                  55                  60                  


Gly Leu Leu Gly Asn Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys 
65                  70                  75                  80  


Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala 
                85                  90                  95      


Asp Ile Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala 
            100                 105                 110         


Thr Gly Ala Trp Val Phe Ser Asn Ala Met Cys Lys Leu Met Lys Gly 
        115                 120                 125             


Ile Tyr Ala Ile Asn Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile 
    130                 135                 140                 


Ser Met Asp Arg Tyr Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg 
145                 150                 155                 160 


Leu Arg Tyr Arg Thr Leu Leu Arg Ser Lys Val Ile Cys Leu Ile Val 
                165                 170                 175     


Trp Gly Val Ser Val Ile Ile Ser Ser Ser Thr Phe Ile Phe Asn Gln 
            180                 185                 190         


Lys Tyr Asn Ile Gln Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr 
        195                 200                 205             


Val Ser Glu Pro Ile Lys Trp Lys Leu Leu Met Leu Gly Leu Glu Leu 
    210                 215                 220                 


Leu Phe Gly Phe Phe Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Met 
225                 230                 235                 240 


Phe Ile Val Lys Thr Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys 
                245                 250                 255     


Ala Ile Arg Val Ile Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln 
            260                 265                 270         


Ile Pro His Asn Met Val Leu Leu Val Thr Ala Ala Asn Leu Gly Asn 
        275                 280                 285             


Met Asn Arg Ser Cys His Ser Glu Lys Leu Leu Gly Tyr Thr Lys Thr 
    290                 295                 300                 


Val Thr Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu 
305                 310                 315                 320 


Tyr Ala Phe Ile Gly Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Met 
                325                 330                 335     


Lys Asp Leu Trp Cys Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser 
            340                 345                 350         


Cys Ala Gly Arg Tyr Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr 
        355                 360                 365             


Ala Asp Asn Asp Asn Ala Ser Ser Phe Thr Met 
    370                 375                 


<210>  126
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O54689|CCR6_MOUSE

<400>  126

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro Cys Ser Leu Glu Glu 
            20                  25                  30          


Val Arg Asn Phe Thr Lys Val Phe Val Pro Ile Ala Tyr Ser Leu Ile 
        35                  40                  45              


Cys Val Phe Gly Leu Leu Gly Asn Ile Met Val Val Met Thr Phe Ala 
    50                  55                  60                  


Phe Tyr Lys Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met 
65                  70                  75                  80  


Ala Ile Thr Asp Ile Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Thr His Ala Thr Asn Thr Trp Val Phe Ser Asp Ala Leu Cys Lys Leu 
            100                 105                 110         


Met Lys Gly Thr Tyr Ala Val Asn Phe Asn Cys Gly Met Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Met Asp Arg Tyr Ile Ala Ile Val Gln Ala Thr Lys 
    130                 135                 140                 


Ser Phe Arg Val Arg Ser Arg Thr Leu Thr His Ser Lys Val Ile Cys 
145                 150                 155                 160 


Val Ala Val Trp Phe Ile Ser Ile Ile Ile Ser Ser Pro Thr Phe Ile 
                165                 170                 175     


Phe Asn Lys Lys Tyr Glu Leu Gln Asp Arg Asp Val Cys Glu Pro Arg 
            180                 185                 190         


Tyr Arg Ser Val Ser Glu Pro Ile Thr Trp Lys Leu Leu Gly Met Gly 
        195                 200                 205             


Leu Glu Leu Phe Phe Gly Phe Phe Thr Pro Leu Leu Phe Met Val Phe 
    210                 215                 220                 


Cys Tyr Leu Phe Ile Ile Lys Thr Leu Val Gln Ala Gln Asn Ser Lys 
225                 230                 235                 240 


Arg His Arg Ala Ile Arg Val Val Ile Ala Val Val Leu Val Phe Leu 
                245                 250                 255     


Ala Cys Gln Ile Pro His Asn Met Val Leu Leu Val Thr Ala Val Asn 
            260                 265                 270         


Thr Gly Lys Val Gly Arg Ser Cys Ser Thr Glu Lys Val Leu Ala Tyr 
        275                 280                 285             


Thr Arg Asn Val Ala Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn 
    290                 295                 300                 


Pro Val Leu Tyr Ala Phe Ile Gly Gln Lys Phe Arg Asn Tyr Phe Met 
305                 310                 315                 320 


Lys Ile Met Lys Asp Val Trp Cys Met Arg Arg Lys Asn Lys Met Pro 
                325                 330                 335     


Gly Phe Leu Cys Ala Arg Val Tyr Ser Glu Ser Tyr Ile Ser Arg Gln 
            340                 345                 350         


Thr Ser Glu Thr Val Glu Asn Asp Asn Ala Ser Ser Phe Thr Met 
        355                 360                 365         


<210>  127
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32248|CCR7_HUMAN

<400>  127

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  128
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|C0ISS3|CCR7_MACFA

<400>  128

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Gly Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  129
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P47774|CCR7_MOUSE

<400>  129

Met Asp Pro Gly Lys Pro Arg Lys Asn Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Phe Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Glu Asn Thr Thr Val Asp Tyr Thr Leu Tyr Glu Ser Val Cys 
        35                  40                  45              


Phe Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Leu Met 
    50                  55                  60                  


Tyr Ser Val Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Ile 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Ile Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Glu Ala Lys Ser Trp Ile Phe Gly Val Tyr Leu 
        115                 120                 125             


Cys Lys Gly Ile Phe Gly Ile Tyr Lys Leu Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Met Leu Ala Leu Phe Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Gly Leu Gln Lys Asn Ser Gly Glu Asp Thr Leu 
        195                 200                 205             


Arg Cys Ser Leu Val Ser Ala Gln Val Glu Ala Leu Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Phe Gly Phe Leu Val Pro Met Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Ile Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Asn Ser Ser Cys Glu Thr Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Ser Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Ser Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Arg Leu 
            340                 345                 350         


Arg His Trp Ser Ser Cys Arg His Val Arg Asn Ala Ser Val Ser Met 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  130
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51685|CCR8_HUMAN

<400>  130

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  131
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|G7NYJ2|CCR8_MACFA

<400>  131

Met Asp Tyr Thr Leu Asp Pro Ser Met Thr Thr Met Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ser Leu Ser Ser Pro Cys Asp Gly Glu Leu Ile Gln Arg 
            20                  25                  30          


Asn Asp Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Asn Ile Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Gln Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Ile Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Ser Leu Val Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Glu Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Asn Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


His Ile Phe Ile Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Phe Arg Ser Ser Ser Ile Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  132
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P56484|CCR8_MOUSE

<400>  132

Met Asp Tyr Thr Met Glu Pro Asn Val Thr Met Thr Asp Tyr Tyr Pro 
1               5                   10                  15      


Asp Phe Phe Thr Ala Pro Cys Asp Ala Glu Phe Leu Leu Arg Gly Ser 
            20                  25                  30          


Met Leu Tyr Leu Ala Ile Leu Tyr Cys Val Leu Phe Val Leu Gly Leu 
        35                  40                  45              


Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Gly Cys Lys Lys Leu 
    50                  55                  60                  


Arg Ser Ile Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ala Ser Asp Leu 
65                  70                  75                  80  


Leu Phe Val Leu Ser Ile Pro Phe Gln Thr His Asn Leu Leu Asp Gln 
                85                  90                  95      


Trp Val Phe Gly Thr Ala Met Cys Lys Val Val Ser Gly Leu Tyr Tyr 
            100                 105                 110         


Ile Gly Phe Phe Ser Ser Met Phe Phe Ile Thr Leu Met Ser Val Asp 
        115                 120                 125             


Arg Tyr Leu Ala Ile Val His Ala Val Tyr Ala Ile Lys Val Arg Thr 
    130                 135                 140                 


Ala Ser Val Gly Thr Ala Leu Ser Leu Thr Val Trp Leu Ala Ala Val 
145                 150                 155                 160 


Thr Ala Thr Ile Pro Leu Met Val Phe Tyr Gln Val Ala Ser Glu Asp 
                165                 170                 175     


Gly Met Leu Gln Cys Phe Gln Phe Tyr Glu Glu Gln Ser Leu Arg Trp 
            180                 185                 190         


Lys Leu Phe Thr His Phe Glu Ile Asn Ala Leu Gly Leu Leu Leu Pro 
        195                 200                 205             


Phe Ala Ile Leu Leu Phe Cys Tyr Val Arg Ile Leu Gln Gln Leu Arg 
    210                 215                 220                 


Gly Cys Leu Asn His Asn Arg Thr Arg Ala Ile Lys Leu Val Leu Thr 
225                 230                 235                 240 


Val Val Ile Val Ser Leu Leu Phe Trp Val Pro Phe Asn Val Ala Leu 
                245                 250                 255     


Phe Leu Thr Ser Leu His Asp Leu His Ile Leu Asp Gly Cys Ala Thr 
            260                 265                 270         


Arg Gln Arg Leu Ala Leu Ala Ile His Val Thr Glu Val Ile Ser Phe 
        275                 280                 285             


Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Ile Gly Glu Lys 
    290                 295                 300                 


Phe Lys Lys His Leu Met Asp Val Phe Gln Lys Ser Cys Ser His Ile 
305                 310                 315                 320 


Phe Leu Tyr Leu Gly Arg Gln Met Pro Val Gly Ala Leu Glu Arg Gln 
                325                 330                 335     


Leu Ser Ser Asn Gln Arg Ser Ser His Ser Ser Thr Leu Asp Asp Ile 
            340                 345                 350         


Leu 
    


<210>  133
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P51686|CCR9_HUMAN

<400>  133

Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys 
65                  70                  75                  80  


Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu 
                85                  90                  95      


Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp 
            100                 105                 110         


Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys 
145                 150                 155                 160 


Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile Trp Val Leu Ala 
                165                 170                 175     


Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu 
            180                 185                 190         


Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr 
        195                 200                 205             


Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile Leu Gly Phe Phe 
    210                 215                 220                 


Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile Ile Ile His Thr 
225                 230                 235                 240 


Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr 
                245                 250                 255     


Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys 
            260                 265                 270         


Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met Phe Ile Ser Asn 
        275                 280                 285             


Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr 
    290                 295                 300                 


Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu 
    


<210>  134
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|Q0H741|CCR9_MACFA

<400>  134

Met Thr Pro Thr Glu Phe Thr Ser Pro Val Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys 
65                  70                  75                  80  


Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu 
                85                  90                  95      


Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp 
            100                 105                 110         


Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys 
145                 150                 155                 160 


Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile Trp Val Leu Ala 
                165                 170                 175     


Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu 
            180                 185                 190         


Ser Gly Ile Ala Val Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr 
        195                 200                 205             


Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile Leu Gly Phe Phe 
    210                 215                 220                 


Leu Pro Phe Met Val Met Ala Cys Cys Tyr Thr Ile Ile Ile His Thr 
225                 230                 235                 240 


Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr 
                245                 250                 255     


Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys 
            260                 265                 270         


Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met Phe Ile Ser Ser 
        275                 280                 285             


Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr 
    290                 295                 300                 


Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu 
    


<210>  135
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9WUT7|CCR9_MOUSE

<400>  135

Met Met Pro Thr Glu Leu Thr Ser Leu Ile Pro Gly Met Phe Asp Asp 
1               5                   10                  15      


Phe Ser Tyr Asp Ser Thr Ala Ser Thr Asp Asp Tyr Met Asn Leu Asn 
            20                  25                  30          


Phe Ser Ser Phe Phe Cys Lys Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Thr Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys 
65                  70                  75                  80  


Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu 
                85                  90                  95      


Phe Leu Ala Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Gly Gln Trp 
            100                 105                 110         


Met Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Ile Ala Ile Val Gln Ala Met Lys Ala Gln Val Trp Arg Gln Lys 
145                 150                 155                 160 


Arg Leu Leu Tyr Ser Lys Met Val Cys Ile Thr Ile Trp Val Met Ala 
                165                 170                 175     


Ala Val Leu Cys Thr Pro Glu Ile Leu Tyr Ser Gln Val Ser Gly Glu 
            180                 185                 190         


Ser Gly Ile Ala Thr Cys Thr Met Val Tyr Pro Lys Asp Lys Asn Ala 
        195                 200                 205             


Lys Leu Lys Ser Ala Val Leu Ile Leu Lys Val Thr Leu Gly Phe Phe 
    210                 215                 220                 


Leu Pro Phe Met Val Met Ala Phe Cys Tyr Thr Ile Ile Ile His Thr 
225                 230                 235                 240 


Leu Val Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr 
                245                 250                 255     


Ile Thr Val Leu Thr Val Phe Ile Met Ser Gln Phe Pro Tyr Asn Ser 
            260                 265                 270         


Ile Leu Val Val Gln Ala Val Asp Ala Tyr Ala Met Phe Ile Ser Asn 
        275                 280                 285             


Cys Thr Ile Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr 
    290                 295                 300                 


Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu 
    


<210>  136
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P46092|CCR10_HUMAN

<400>  136

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  137
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5UAP1|CCR10_MACFA

<400>  137

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Glu Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Arg Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Gly Cys Pro Ser Gly Pro His Arg 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  138
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9JL21|CCR10_MOUSE

<400>  138

Met Gly Thr Lys Pro Thr Glu Gln Val Ser Trp Gly Leu Tyr Ser Gly 
1               5                   10                  15      


Tyr Asp Glu Glu Ala Tyr Ser Val Gly Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Met Val Ala Val Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Thr Thr Arg Ser Pro Thr Ser Val His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Asn Leu Gly Ser Thr Thr 
            100                 105                 110         


Cys Arg Ala Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Gln Arg Pro Ser Thr Pro Ser Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Phe Val Trp Leu Leu Ser Leu Phe Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Arg Asp Gly Pro Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Ser Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Val Leu Gly Phe Ala Leu Pro Leu Gly Val Met Ala 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Val Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Ser Ser Ser Lys Arg Lys 
        275                 280                 285             


Asp Leu Ala Leu Leu Val Thr Gly Gly Leu Thr Leu Val Arg Cys Ser 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Arg Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Gln Gly Gly Gly Cys Ser Pro Lys Pro Asn Pro 
                325                 330                 335     


Arg Gly Arg Cys Pro Arg Arg Leu Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  139
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25024|CXCR1_HUMAN

<400>  139

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  140
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5X9E4|CXCR1_MACFA

<400>  140

Met Ser Asn Ala Thr Asp Pro Gln Met Gly Asp Asp Asp Tyr Asp Leu 
1               5                   10                  15      


Asn Phe Thr Gly Met Pro Pro Thr Asp Glu Asp Tyr Ser Pro Cys Arg 
            20                  25                  30          


Leu Glu Thr Gln Ser Leu Asn Lys Tyr Val Val Ile Val Thr Tyr Ala 
        35                  40                  45              


Leu Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val 
    50                  55                  60                  


Ile Leu Tyr Arg Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu 
65                  70                  75                  80  


Asn Leu Ala Met Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp 
                85                  90                  95      


Ala Ala Ser Lys Ala Tyr His Pro Asn Asn Ala Thr Pro Val Cys Tyr 
            100                 105                 110         


Glu Val Leu Gly Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile 
        115                 120                 125             


Leu Pro His Thr Phe Gly Phe Thr Leu Pro Leu Leu Ile Met Leu Phe 
    130                 135                 140                 


Cys Tyr Gly Phe Thr Leu His Thr Leu Phe Lys Ala His Ile Gly Gln 
145                 150                 155                 160 


Lys His Arg Ala Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu 
                165                 170                 175     


Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met 
            180                 185                 190         


Arg Thr His Leu Ile Lys Glu Ser Cys Glu Arg Arg Asn Asp Ile Gly 
        195                 200                 205             


Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu 
    210                 215                 220                 


Asn Pro Ile Ile Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe 
225                 230                 235                 240 


Leu Lys Ile Leu Ala Thr His Gly Leu Val Ser Lys Glu Phe Leu Ala 
                245                 250                 255     


Arg His His Val Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser 
            260                 265                 270         


Asn Leu 
        


<210>  141
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q810W6|CXCR1_MOUSE

<400>  141

Met Ala Glu Ala Glu Tyr Phe Ile Trp Thr Asn Pro Glu Gly Asp Phe 
1               5                   10                  15      


Glu Lys Glu Phe Gly Asn Ile Thr Gly Met Leu Pro Thr Gly Asp Tyr 
            20                  25                  30          


Phe Ile Pro Cys Lys Arg Val Pro Ile Thr Asn Arg Gln Ala Leu Val 
        35                  40                  45              


Val Phe Tyr Ala Leu Val Ser Leu Leu Ser Leu Leu Gly Asn Ser Leu 
    50                  55                  60                  


Val Met Leu Val Ile Leu Tyr Arg Arg Arg Thr Arg Ser Val Met Asp 
65                  70                  75                  80  


Val Tyr Val Leu Asn Leu Ala Ile Ala Asp Leu Leu Phe Ser Leu Thr 
                85                  90                  95      


Leu Pro Phe Leu Ala Val Ser Lys Leu Lys Gly Trp Ile Phe Gly Thr 
            100                 105                 110         


Pro Leu Cys Lys Met Val Ser Leu Leu Lys Glu Phe Asn Phe Phe Ser 
        115                 120                 125             


Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile 
    130                 135                 140                 


Val His Ala Thr Arg Thr Leu Ala Arg Lys Arg Tyr Leu Val Lys Phe 
145                 150                 155                 160 


Val Cys Val Gly Ile Trp Gly Leu Ser Leu Ile Leu Ser Leu Pro Phe 
                165                 170                 175     


Ala Ile Phe Arg Gln Ala Tyr Lys Pro Phe Arg Ser Gly Thr Val Cys 
            180                 185                 190         


Tyr Glu Val Leu Gly Glu Ala Thr Thr Asp Phe Arg Met Thr Leu Arg 
        195                 200                 205             


Gly Leu Ser His Ile Phe Gly Phe Leu Leu Pro Leu Leu Thr Met Leu 
    210                 215                 220                 


Val Cys Tyr Gly Leu Thr Leu Arg Met Leu Phe Lys Thr His Met Arg 
225                 230                 235                 240 


Gln Lys His Arg Ala Met Gly Val Ile Phe Ala Val Val Leu Val Phe 
                245                 250                 255     


Leu Leu Cys Cys Leu Pro Tyr Asn Leu Val Leu Leu Ser Asp Thr Leu 
            260                 265                 270         


Leu Gly Ala His Leu Ile Glu Asp Thr Cys Glu Arg Arg Asn Asp Ile 
        275                 280                 285             


Asp Gln Ala Leu Tyr Ile Thr Glu Ile Leu Gly Phe Ser His Ser Cys 
    290                 295                 300                 


Leu Asn Pro Ile Ile Tyr Ala Phe Val Gly Gln Asn Phe Arg His Glu 
305                 310                 315                 320 


Phe Leu Lys Ile Leu Ala Asn His Gly Leu Val Arg Lys Glu Val Leu 
                325                 330                 335     


Thr His Arg Arg Val Ala Phe His Thr Ser Leu Thr Ala Ile Tyr 
            340                 345                 350     


<210>  142
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25025|CXCR2_HUMAN

<400>  142

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  143
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q28519|CXCR2_MACMU

<400>  143

Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Leu Trp Lys Gly Glu Asp 
1               5                   10                  15      


Phe Ser Asn Tyr Ser Tyr Ser Ser Asp Leu Pro Pro Ser Leu Pro Asp 
            20                  25                  30          


Val Ala Pro Cys Arg Pro Glu Ser Leu Glu Ile Asn Lys Tyr Phe Val 
        35                  40                  45              


Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu Gly Asn Ser 
    50                  55                  60                  


Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg Ser Val Thr 
65                  70                  75                  80  


Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu 
                85                  90                  95      


Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp Ile Phe Gly 
            100                 105                 110         


Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val Asn Phe Tyr 
        115                 120                 125             


Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala 
    130                 135                 140                 


Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr Leu Val Lys 
145                 150                 155                 160 


Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu Ala Leu Pro 
                165                 170                 175     


Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val Ser Pro Ala 
            180                 185                 190         


Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg Met Leu Leu 
        195                 200                 205             


Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu Leu Ile Met 
    210                 215                 220                 


Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys Ala His Met 
225                 230                 235                 240 


Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val Val Leu Ile 
                245                 250                 255     


Phe Leu Leu Cys Trp Leu Pro Tyr Ser Leu Val Leu Leu Ala Asp Thr 
            260                 265                 270         


Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg Arg Asn His 
        275                 280                 285             


Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile Leu His Ser 
    290                 295                 300                 


Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys Phe Arg His 
305                 310                 315                 320 


Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser Lys Asp Ser 
                325                 330                 335     


Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser Ser Gly His 
            340                 345                 350         


Thr 
    


<210>  144
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P35343|CXCR2_MOUSE

<400>  144

Met Gly Glu Phe Lys Val Asp Lys Phe Asn Ile Glu Asp Phe Phe Ser 
1               5                   10                  15      


Gly Asp Leu Asp Ile Phe Asn Tyr Ser Ser Gly Met Pro Ser Ile Leu 
            20                  25                  30          


Pro Asp Ala Val Pro Cys His Ser Glu Asn Leu Glu Ile Asn Ser Tyr 
        35                  40                  45              


Ala Val Val Val Ile Tyr Val Leu Val Thr Leu Leu Ser Leu Val Gly 
    50                  55                  60                  


Asn Ser Leu Val Met Leu Val Ile Leu Tyr Asn Arg Ser Thr Cys Ser 
65                  70                  75                  80  


Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Ile Ala Asp Leu Phe Phe 
                85                  90                  95      


Ala Leu Thr Leu Pro Val Trp Ala Ala Ser Lys Val Asn Gly Trp Thr 
            100                 105                 110         


Phe Gly Ser Thr Leu Cys Lys Ile Phe Ser Tyr Val Lys Glu Val Thr 
        115                 120                 125             


Phe Tyr Ser Ser Val Leu Leu Leu Ala Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Leu Ala Ile Val His Ala Thr Ser Thr Leu Ile Gln Lys Arg His Leu 
145                 150                 155                 160 


Val Lys Phe Val Cys Ile Ala Met Trp Leu Leu Ser Val Ile Leu Ala 
                165                 170                 175     


Leu Pro Ile Leu Ile Leu Arg Asn Pro Val Lys Val Asn Leu Ser Thr 
            180                 185                 190         


Leu Val Cys Tyr Glu Asp Val Gly Asn Asn Thr Ser Arg Leu Arg Val 
        195                 200                 205             


Val Leu Arg Ile Leu Pro Gln Thr Phe Gly Phe Leu Val Pro Leu Leu 
    210                 215                 220                 


Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys Ala 
225                 230                 235                 240 


His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val Val 
                245                 250                 255     


Leu Val Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Phe Thr 
            260                 265                 270         


Asp Thr Leu Met Arg Thr Lys Leu Ile Lys Glu Thr Cys Glu Arg Arg 
        275                 280                 285             


Asp Asp Ile Asp Lys Ala Leu Asn Ala Thr Glu Ile Leu Gly Phe Leu 
    290                 295                 300                 


His Ser Cys Leu Asn Pro Ile Ile Tyr Ala Phe Ile Gly Gln Lys Phe 
305                 310                 315                 320 


Arg His Gly Leu Leu Lys Ile Met Ala Thr Tyr Gly Leu Val Ser Lys 
                325                 330                 335     


Glu Phe Leu Ala Lys Glu Gly Arg Pro Ser Phe Val Ser Ser Ser Ser 
            340                 345                 350         


Ala Asn Thr Ser Thr Thr Leu 
        355                 


<210>  145
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P49682|CXCR3_HUMAN

<400>  145

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe 
    50                  55                  60                  


Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser 
65                  70                  75                  80  


Arg Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala 
                85                  90                  95      


Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp 
            100                 105                 110         


Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly 
        115                 120                 125             


Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr 
145                 150                 155                 160 


Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp 
                165                 170                 175     


Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala 
            180                 185                 190         


His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro 
        195                 200                 205             


Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe 
    210                 215                 220                 


Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala 
225                 230                 235                 240 


Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu 
                245                 250                 255     


Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His 
            260                 265                 270         


Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg 
        275                 280                 285             


Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser 
    290                 295                 300                 


Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu 
                325                 330                 335     


Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg 
            340                 345                 350         


Arg Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
        355                 360                 365             


<210>  146
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|A0A2K5UV19|CXCR3_MACFA

<400>  146

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe 
    50                  55                  60                  


Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser 
65                  70                  75                  80  


Arg Arg Ala Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala 
                85                  90                  95      


Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp 
            100                 105                 110         


Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly 
        115                 120                 125             


Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr 
145                 150                 155                 160 


Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp 
                165                 170                 175     


Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala 
            180                 185                 190         


His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro 
        195                 200                 205             


Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe 
    210                 215                 220                 


Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala 
225                 230                 235                 240 


Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu 
                245                 250                 255     


Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His 
            260                 265                 270         


Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg 
        275                 280                 285             


Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser 
    290                 295                 300                 


Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu 
                325                 330                 335     


Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg 
            340                 345                 350         


Arg Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
        355                 360                 365             


<210>  147
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O88410|CXCR3_MOUSE

<400>  147

Met Tyr Leu Glu Val Ser Glu Arg Gln Val Leu Asp Ala Ser Asp Phe 
1               5                   10                  15      


Ala Phe Leu Leu Glu Asn Ser Thr Ser Pro Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Phe Ser Asp Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
        35                  40                  45              


Asn Phe Asp Arg Thr Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu 
    50                  55                  60                  


Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Gln 
65                  70                  75                  80  


Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val 
                85                  90                  95      


Ala Asp Val Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala 
            100                 105                 110         


Ala Val Gln Trp Val Phe Gly Pro Gly Leu Cys Lys Val Ala Gly Ala 
        115                 120                 125             


Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Phe Leu Leu Ala Cys Ile 
    130                 135                 140                 


Ser Phe Asp Arg Tyr Leu Ser Ile Val His Ala Thr Gln Ile Tyr Arg 
145                 150                 155                 160 


Arg Asp Pro Arg Val Arg Val Ala Leu Thr Cys Ile Val Val Trp Gly 
                165                 170                 175     


Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Tyr Leu Ser Ala Asn 
            180                 185                 190         


Tyr Asp Gln Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln 
        195                 200                 205             


Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu 
    210                 215                 220                 


Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val 
225                 230                 235                 240 


Leu Leu Val Ser Arg Gly Gln Arg Arg Phe Arg Ala Met Arg Leu Val 
                245                 250                 255     


Val Val Val Val Ala Ala Phe Ala Val Cys Trp Thr Pro Tyr His Leu 
            260                 265                 270         


Val Val Leu Val Asp Ile Leu Met Asp Val Gly Val Leu Ala Arg Asn 
        275                 280                 285             


Cys Gly Arg Glu Ser His Val Asp Val Ala Lys Ser Val Thr Ser Gly 
    290                 295                 300                 


Met Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val 
305                 310                 315                 320 


Gly Val Lys Phe Arg Glu Gln Met Trp Met Leu Phe Thr Arg Leu Gly 
                325                 330                 335     


Arg Ser Asp Gln Arg Gly Pro Gln Arg Gln Pro Ser Ser Ser Arg Arg 
            340                 345                 350         


Glu Ser Ser Trp Ser Glu Thr Thr Glu Ala Ser Tyr Leu Gly Leu 
        355                 360                 365         


<210>  148
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P61073|CXCR4_HUMAN

<400>  148

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210>  149
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q28474|CXCR4_MACFA

<400>  149

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Ile Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala His Phe Asn Arg Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Lys Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Ser 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210>  150
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P70658|CXCR4_MOUSE

<400>  150

Met Glu Pro Ile Ser Val Ser Ile Tyr Thr Ser Asp Asn Tyr Ser Glu 
1               5                   10                  15      


Glu Val Gly Ser Gly Asp Tyr Asp Ser Asn Lys Glu Pro Cys Phe Arg 
            20                  25                  30          


Asp Glu Asn Val His Phe Asn Arg Ile Phe Leu Pro Thr Ile Tyr Phe 
        35                  40                  45              


Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val 
    50                  55                  60                  


Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu 
65                  70                  75                  80  


His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp 
                85                  90                  95      


Ala Val Asp Ala Met Ala Asp Trp Tyr Phe Gly Lys Phe Leu Cys Lys 
            100                 105                 110         


Ala Val His Ile Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile 
        115                 120                 125             


Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr 
    130                 135                 140                 


Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Ala Val Tyr Val 
145                 150                 155                 160 


Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe 
                165                 170                 175     


Ala Asp Val Ser Gln Gly Asp Ile Ser Gln Gly Asp Asp Arg Tyr Ile 
            180                 185                 190         


Cys Asp Arg Leu Tyr Pro Asp Ser Leu Trp Met Val Val Phe Gln Phe 
        195                 200                 205             


Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser 
    210                 215                 220                 


Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln 
225                 230                 235                 240 


Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe 
                245                 250                 255     


Ala Cys Trp Leu Pro Tyr Tyr Val Gly Ile Ser Ile Asp Ser Phe Ile 
            260                 265                 270         


Leu Leu Gly Val Ile Lys Gln Gly Cys Asp Phe Glu Ser Ile Val His 
        275                 280                 285             


Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu 
    290                 295                 300                 


Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Ser Ser Ala 
305                 310                 315                 320 


Gln His Ala Leu Asn Ser Met Ser Arg Gly Ser Ser Leu Lys Ile Leu 
                325                 330                 335     


Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu 
            340                 345                 350         


Ser Ser Ser Phe His Ser Ser 
        355                 


<210>  151
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P32302|CXCR5_HUMAN

<400>  151

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  152
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >tr|G8F5K4|CXCR5_MACFA

<400>  152

Met Asn Tyr Pro Leu Met Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Leu Glu Phe Asp Lys Phe Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Phe Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Ala His Pro Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Val Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Glu Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Lys Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  153
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q04683|CXCR5_MOUSE

<400>  153

Met Asn Tyr Pro Leu Thr Leu Asp Met Gly Ser Ile Thr Tyr Asn Met 
1               5                   10                  15      


Asp Asp Leu Tyr Lys Glu Leu Ala Phe Tyr Ser Asn Ser Thr Glu Ile 
            20                  25                  30          


Pro Leu Gln Asp Ser Asn Phe Cys Ser Thr Val Glu Gly Pro Leu Leu 
        35                  40                  45              


Thr Ser Phe Lys Ala Val Phe Met Pro Val Ala Tyr Ser Leu Ile Phe 
    50                  55                  60                  


Leu Leu Gly Met Met Gly Asn Ile Leu Val Leu Val Ile Leu Glu Arg 
65                  70                  75                  80  


His Arg His Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu 
            100                 105                 110         


Gly Ser Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile 
        115                 120                 125             


Ala Leu His Lys Ile Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ala Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr 
145                 150                 155                 160 


Arg Arg Arg Arg Leu Leu Ser Ile His Ile Thr Cys Thr Ala Ile Trp 
                165                 170                 175     


Leu Ala Gly Phe Leu Phe Ala Leu Pro Glu Leu Leu Phe Ala Lys Val 
            180                 185                 190         


Gly Gln Pro His Asn Asn Asp Ser Leu Pro Gln Cys Thr Phe Ser Gln 
        195                 200                 205             


Glu Asn Glu Ala Glu Thr Arg Ala Trp Phe Thr Ser Arg Phe Leu Tyr 
    210                 215                 220                 


His Ile Gly Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr 
225                 230                 235                 240 


Val Gly Val Val His Arg Leu Leu Gln Ala Gln Arg Arg Pro Gln Arg 
                245                 250                 255     


Gln Lys Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu 
            260                 265                 270         


Cys Trp Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Glu Arg 
        275                 280                 285             


Leu Lys Ala Val Asn Ser Ser Cys Glu Leu Ser Gly Tyr Leu Ser Val 
    290                 295                 300                 


Ala Ile Thr Leu Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn 
305                 310                 315                 320 


Pro Met Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser 
                325                 330                 335     


Arg Leu Leu Thr Lys Leu Gly Cys Ala Gly Pro Ala Ser Leu Cys Gln 
            340                 345                 350         


Leu Phe Pro Asn Trp Arg Lys Ser Ser Leu Ser Glu Ser Glu Asn Ala 
        355                 360                 365             


Thr Ser Leu Thr Thr Phe 
    370                 


<210>  154
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|O00574|CXCR6_HUMAN

<400>  154

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  155
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9BDS6|CXCR6_MACFA

<400>  155

Met Ala Glu Tyr Asp His Tyr Glu Asp Asp Gly Phe Leu Asn Ser Phe 
1               5                   10                  15      


Asn Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Arg Lys 
            20                  25                  30          


Val Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val 
        35                  40                  45              


Gly Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln 
    50                  55                  60                  


Ser Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val 
65                  70                  75                  80  


Phe Val Cys Thr Leu Pro Phe Trp Thr Tyr Ala Gly Ile His Glu Trp 
                85                  90                  95      


Ile Phe Gly Gln Val Met Cys Lys Thr Leu Leu Gly Val Tyr Thr Ile 
            100                 105                 110         


Asn Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg 
        115                 120                 125             


Phe Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys 
    130                 135                 140                 


Arg Met Thr Trp Gly Lys Val Ile Cys Leu Leu Ile Trp Val Ile Ser 
145                 150                 155                 160 


Leu Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu 
                165                 170                 175     


Asp Lys Leu Ile Cys Gly Tyr His Asp Glu Glu Ile Ser Thr Val Val 
            180                 185                 190         


Leu Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Ala Met 
        195                 200                 205             


Ile Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly 
    210                 215                 220                 


Phe Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val 
225                 230                 235                 240 


Phe Leu Leu Thr Gln Thr Pro Phe Asn Leu Val Lys Leu Ile Arg Ser 
                245                 250                 255     


Thr Arg Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Ile 
            260                 265                 270         


Val Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu 
        275                 280                 285             


Tyr Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val 
    290                 295                 300                 


Lys Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys 
305                 310                 315                 320 


Ser Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu 
                325                 330                 335     


Ala Thr Ser Met Phe Gln Leu 
            340             


<210>  156
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9EQ16|CXCR6_MOUSE

<400>  156

Met Asp Asp Gly His Gln Glu Ser Ala Leu Tyr Asp Gly His Tyr Glu 
1               5                   10                  15      


Gly Asp Phe Trp Leu Phe Asn Asn Ser Ser Asp Asn Ser Gln Glu Asn 
            20                  25                  30          


Lys Arg Phe Leu Lys Phe Lys Glu Val Phe Leu Pro Cys Val Tyr Leu 
        35                  40                  45              


Val Val Phe Val Phe Gly Leu Leu Gly Asn Ser Leu Val Leu Ile Ile 
    50                  55                  60                  


Tyr Ile Phe Tyr Gln Lys Leu Arg Thr Leu Thr Asp Val Phe Leu Leu 
65                  70                  75                  80  


Asn Leu Pro Leu Ala Asp Leu Val Phe Val Cys Thr Leu Pro Phe Trp 
                85                  90                  95      


Ala Tyr Ala Gly Thr Tyr Glu Trp Val Phe Gly Thr Val Met Cys Lys 
            100                 105                 110         


Thr Leu Arg Gly Met Tyr Thr Met Asn Phe Tyr Val Ser Met Leu Thr 
        115                 120                 125             


Leu Thr Cys Ile Thr Val Asp Arg Phe Ile Val Val Val Gln Ala Thr 
    130                 135                 140                 


Lys Ala Phe Asn Arg Gln Ala Lys Trp Lys Ile Trp Gly Gln Val Ile 
145                 150                 155                 160 


Cys Leu Leu Ile Trp Val Val Ser Leu Leu Val Ser Leu Pro Gln Ile 
                165                 170                 175     


Ile Tyr Gly His Val Gln Asp Ile Asp Lys Leu Ile Cys Gln Tyr His 
            180                 185                 190         


Ser Glu Glu Ile Ser Thr Met Val Leu Val Ile Gln Met Thr Leu Gly 
        195                 200                 205             


Phe Phe Leu Pro Leu Leu Thr Met Ile Leu Cys Tyr Ser Gly Ile Ile 
    210                 215                 220                 


Lys Thr Leu Leu His Ala Arg Asn Phe Gln Lys His Lys Ser Leu Lys 
225                 230                 235                 240 


Ile Ile Phe Leu Val Val Ala Val Phe Leu Leu Thr Gln Thr Pro Phe 
                245                 250                 255     


Asn Leu Ala Met Leu Ile Gln Ser Thr Ser Trp Glu Tyr Tyr Thr Ile 
            260                 265                 270         


Thr Ser Phe Lys Tyr Ala Ile Val Val Thr Glu Ala Ile Ala Tyr Phe 
        275                 280                 285             


Arg Ala Cys Leu Asn Pro Val Leu Tyr Ala Phe Val Gly Leu Lys Phe 
    290                 295                 300                 


Arg Lys Asn Val Trp Lys Leu Met Lys Asp Ile Gly Cys Leu Ser His 
305                 310                 315                 320 


Leu Gly Val Ser Ser Gln Trp Lys Ser Ser Glu Asp Ser Ser Lys Thr 
                325                 330                 335     


Cys Ser Ala Ser His Asn Val Glu Thr Thr Ser Met Phe Gln Leu 
            340                 345                 350     


<210>  157
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P49238|CX3CR1_HUMAN_TRD

<400>  157

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala 
            20  


<210>  158
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q6Y3J6|CX3CR1_MACFA_TRD

<400>  158

Leu Arg Asn Val Glu Ala Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ile Met Ser Tyr 
            20  


<210>  159
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9Z0D9|CX3CR1_MOUSE_TRD

<400>  159

Met Ser Thr Ser Phe Pro Glu Leu Asp Leu Glu Asn Phe Glu Tyr Asp 
1               5                   10                  15      


Asp Ser Ala Glu Ala 
            20      


<210>  160
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P49238|CX3CR1_HUMAN_N term


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  160

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Xaa Tyr Ile Gly Asp Ile Val Val Phe Gly Thr 
            20                  25                  30      


<210>  161
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q6Y3J6|CX3CR1_MACFA_N term


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  161

Leu Arg Asn Val Glu Ala Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ile Met Ser Tyr Xaa Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser 
            20                  25                  30      


<210>  162
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q9Z0D9|CX3CR1_MOUSE_N term


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  162

Met Ser Thr Ser Phe Pro Glu Leu Asp Leu Glu Asn Phe Glu Tyr Asp 
1               5                   10                  15      


Asp Ser Ala Glu Ala Xaa Tyr Leu Gly Asp Ile Val Ala Phe Gly Thr 
            20                  25                  30          


<210>  163
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25024|CXCR1_HUMAN_TRD

<400>  163

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro 
            20                  25                  


<210>  164
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q2YEG0|CXCR1_MACMU_TRD

<400>  164

Met Ser Asn Ala Thr Asp Pro Gln Met Gly Asp Asp Asp Tyr Asp Leu 
1               5                   10                  15      


Asn Phe Thr Gly Met Pro Pro Thr Asp Glu Asp Tyr Ser Pro 
            20                  25                  30  


<210>  165
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q810W6|CXCR1_MOUSE_TRD

<400>  165

Met Ala Glu Ala Glu Tyr Phe Ile Trp Thr Asn Pro Glu Gly Asp Phe 
1               5                   10                  15      


Glu Lys Glu Phe Gly Asn Ile Thr Gly Met Leu Pro Thr Gly Asp Tyr 
            20                  25                  30          


Phe Ile Pro 
        35  


<210>  166
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|P25024|CXCR1_HUMAN_N term


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  166

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Xaa Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys 
        35                  


<210>  167
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q2YEG0|CXCR1_MACMU_N term


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  167

Met Ser Asn Ala Thr Asp Pro Gln Met Gly Asp Asp Asp Tyr Asp Leu 
1               5                   10                  15      


Asn Phe Thr Gly Met Pro Pro Thr Asp Glu Asp Tyr Ser Pro Xaa Arg 
            20                  25                  30          


Leu Glu Thr Gln Ser Leu Asn Lys Tyr Val Val Ile Val Thr 
        35                  40                  45      


<210>  168
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >sp|Q810W6|CXCR1_MOUSE_N term


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<400>  168

Met Ala Glu Ala Glu Tyr Phe Ile Trp Thr Asn Pro Glu Gly Asp Phe 
1               5                   10                  15      


Glu Lys Glu Phe Gly Asn Ile Thr Gly Met Leu Pro Thr Gly Asp Tyr 
            20                  25                  30          


Phe Ile Pro Xaa Lys Arg Val Pro Ile Thr Asn Arg 
        35                  40                  


<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_VH

<400>  201

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gln Leu Gly Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  202
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_HCDR1

<400>  202

Ser Tyr Gly Met His 
1               5   


<210>  203
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_HCDR2

<400>  203

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  204
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_HCDR3

<400>  204

Gly Arg Gln Leu Gly Ser 
1               5       


<210>  205
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_VL

<400>  205

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  206
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_LCDR1

<400>  206

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_LCDR2

<400>  207

Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210>  208
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_LCDR3

<400>  208

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  209
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_VH

<400>  209
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atctctggca gcggcggcag cacatattac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagaggcaga      300

cagctcggct cttggggaca gggaacactg gttacagtgt cctca                      345


<210>  210
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_VL

<400>  210
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgtactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac ggcaacaaca acagacccag cggcgtgccc      180

gatagattca gcggctctaa gtctggcaca agcgccagcc tggccatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggctgggtt      300

ttcggcggag gcaccaaact gacagtgcta                                       330


<210>  211
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_Heavy Chain

<400>  211

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gln Leu Gly Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  212
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_Light Chain

<400>  212

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  213
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_Heavy Chain

<400>  213
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atctctggca gcggcggcag cacatattac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagaggcaga      300

cagctcggct cttggggaca gggaacactg gttacagtgt cctcagccag caccaagggc      360

cccagcgtgt tccctctggc ccctagcagc aagagcacat ctggcggaac agccgccctg      420

ggctgcctcg tgaaggacta ctttcccgag cccgtgaccg tgtcctggaa ctctggcgct      480

ctgacaagcg gcgtgcacac ctttccagcc gtgctgcaga gcagcggcct gtactctctg      540

agcagcgtcg tgacagtgcc cagcagctct ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagaaggtgg aacccaagag ctgcgacaag      660

acccacacct gtcccccttg tcctgccccc gaactgctgg gaggcccttc cgtgttcctg      720

ttccccccaa agcccaagga caccctgatg atcagccgga cccccgaagt gacctgcgtg      780

gtggtggatg tgtcccacga ggaccctgaa gtgaagttca attggtacgt ggacggcgtg      840

gaagtgcaca acgccaagac caagcctaga gaggaacagt acaacagcac ctaccgggtg      900

gtgtccgtgc tgacagtgct gcaccaggac tggctgaacg gcaaagagta caagtgcaag      960

gtgtccaaca aggccctgcc tgcccccatc gagaaaacca tcagcaaggc caagggccag     1020

ccccgcgaac cccaggtgta cacactgccc ccaagcaggg acgagctgac caagaaccag     1080

gtgtccctga cctgtctcgt gaaaggcttc tacccctccg atatcgccgt ggaatgggag     1140

agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1200

tcattcttcc tgtacagcaa gctgaccgtg gacaagtccc ggtggcagca gggcaacgtg     1260

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgagc     1320

ctgagccctg gc                                                         1332


<210>  214
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14095_497A-M005-E07 -hIgG1Lambda_Light Chain

<400>  214
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgtactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac ggcaacaaca acagacccag cggcgtgccc      180

gatagattca gcggctctaa gtctggcaca agcgccagcc tggccatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggctgggtt      300

ttcggcggag gcaccaaact gacagtgcta ggccagccta aagccgcccc tagcgtgacc      360

ctgttccctc caagcagcga ggaactgcag gccaacaagg ccaccctcgt gtgcctgatc      420

agcgacttct atcctggcgc cgtgaccgtg gcctggaagg ccgatagctc tcctgtgaag      480

gccggcgtgg aaaccaccac ccctagcaag cagagcaaca acaaatacgc cgccagcagc      540

tacctgagcc tgacccccga gcagtggaag tcccacagat cctacagctg ccaagtgacc      600

cacgagggca gcaccgtgga aaagacagtg gcccctaccg agtgcagc                   648


<210>  215
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_VH

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Arg Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_HCDR1

<400>  216

Asp Tyr Gly Val His 
1               5   


<210>  217
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_HCDR2

<400>  217

Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  218
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_HCDR3

<400>  218

Arg Gly Ala 
1           


<210>  219
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_VL

<400>  219

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Phe Asn Ile Gly Ser His 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  220
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_LCDR1

<400>  220

Ser Gly Ser Ser Phe Asn Ile Gly Ser His Phe Val Tyr 
1               5                   10              


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_LCDR2

<400>  221

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  222
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_LCDR3

<400>  222

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  223
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_VH

<400>  223
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc gattatggcg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtttcaggc gtgtcctgga acggcagcag aacccactat      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gacaagaggc      300

gcttggggcc agggcacact ggtcacagtt tcttca                                336


<210>  224
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_VL

<400>  224
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctt caacatcggc agccacttcg tgtactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac aagaacaacc agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggccctgtt      300

tttggcggag gcaccaagct gacagtgcta                                       330


<210>  225
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_Heavy Chain

<400>  225

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Arg Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440     


<210>  226
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_Light Chain

<400>  226

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Phe Asn Ile Gly Ser His 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  227
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_Heavy Chain

<400>  227
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc gattatggcg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtttcaggc gtgtcctgga acggcagcag aacccactat      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gacaagaggc      300

gcttggggcc agggcacact ggtcacagtt tcttcagcca gcaccaaggg ccccagcgtg      360

ttccctctgg cccctagcag caagagcaca tctggcggaa cagccgccct gggctgcctc      420

gtgaaggact actttcccga gcccgtgacc gtgtcctgga actctggcgc tctgacaagc      480

ggcgtgcaca cctttccagc cgtgctgcag agcagcggcc tgtactctct gagcagcgtc      540

gtgacagtgc ccagcagctc tctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaggtgga caagaaggtg gaacccaaga gctgcgacaa gacccacacc      660

tgtccccctt gtcctgcccc cgaactgctg ggaggccctt ccgtgttcct gttcccccca      720

aagcccaagg acaccctgat gatcagccgg acccccgaag tgacctgcgt ggtggtggat      780

gtgtcccacg aggaccctga agtgaagttc aattggtacg tggacggcgt ggaagtgcac      840

aacgccaaga ccaagcctag agaggaacag tacaacagca cctaccgggt ggtgtccgtg      900

ctgacagtgc tgcaccagga ctggctgaac ggcaaagagt acaagtgcaa ggtgtccaac      960

aaggccctgc ctgcccccat cgagaaaacc atcagcaagg ccaagggcca gccccgcgaa     1020

ccccaggtgt acacactgcc cccaagcagg gacgagctga ccaagaacca ggtgtccctg     1080

acctgtctcg tgaaaggctt ctacccctcc gatatcgccg tggaatggga gagcaacggc     1140

cagcccgaga acaactacaa gaccaccccc cctgtgctgg acagcgacgg ctcattcttc     1200

ctgtacagca agctgaccgt ggacaagtcc cggtggcagc agggcaacgt gttcagctgc     1260

agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgag cctgagccct     1320

ggc                                                                   1323


<210>  228
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-14099_497A-M005-F02 -hIgG1Lambda_Light Chain

<400>  228
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctt caacatcggc agccacttcg tgtactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac aagaacaacc agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggccctgtt      300

tttggcggag gcaccaagct gacagtgcta ggccagccta aagccgcccc tagcgtgacc      360

ctgttccctc caagcagcga ggaactgcag gccaacaagg ccaccctcgt gtgcctgatc      420

agcgacttct atcctggcgc cgtgaccgtg gcctggaagg ccgatagctc tcctgtgaag      480

gccggcgtgg aaaccaccac ccctagcaag cagagcaaca acaaatacgc cgccagcagc      540

tacctgagcc tgacccccga gcagtggaag tcccacagat cctacagctg ccaagtgacc      600

cacgagggca gcaccgtgga aaagacagtg gcccctaccg agtgcagc                   648


<210>  229
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_VH

<400>  229

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Arg Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  230
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_HCDR1

<400>  230

Asp Tyr Gly Val His 
1               5   


<210>  231
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_HCDR2

<400>  231

Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  232
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_HCDR3

<400>  232

Arg Gly Ala 
1           


<210>  233
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_VL

<400>  233

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Phe Asn Ile Gly Ser His 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  234
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_LCDR1

<400>  234

Ser Gly Ser Ser Phe Asn Ile Gly Ser His Phe Val Tyr 
1               5                   10              


<210>  235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_LCDR2

<400>  235

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  236
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_LCDR3

<400>  236

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  237
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_VH

<400>  237
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc gattatggcg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtttcaggc gtgtcctgga acggcagcag aacccactat      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gacaagaggc      300

gcttggggcc agggcacact ggtcacagtt tcttca                                336


<210>  238
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_VL

<400>  238
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctt caacatcggc agccacttcg tgtactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac aagaacaacc agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggccctgtt      300

tttggcggag gcaccaagct gacagtgcta                                       330


<210>  239
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_Heavy Chain

<400>  239

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Arg Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
        115                 120                 125             


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
                165                 170                 175     


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
            180                 185                 190         


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
    210                 215                 220                 


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
            260                 265                 270         


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
        275                 280                 285             


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
    290                 295                 300                 


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
305                 310                 315                 320 


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
                325                 330                 335     


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
            340                 345                 350         


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
        355                 360                 365             


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
                405                 410                 415     


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440         


<210>  240
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_Light Chain

<400>  240

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Phe Asn Ile Gly Ser His 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  241
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_Heavy Chain

<400>  241
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc gattatggcg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtttcaggc gtgtcctgga acggcagcag aacccactat      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gacaagaggc      300

gcttggggcc agggcacact ggtcacagtt tcttcagcca agaccaccgc ccccagcgtg      360

taccctctgg ctcctgtgtg tggcgatacc accggcagct ctgtgaccct gggctgcctc      420

gtgaagggct acttccctga gccagtgacc ctgacctgga acagcggctc tctgtctagc      480

ggcgtgcaca cctttccagc cgtgctgcag agcgacctgt acaccctgag cagcagcgtg      540

accgtgacca gcagcacatg gcccagccag agcatcacct gtaacgtggc ccaccctgcc      600

agctccacca aggtggacaa gaagatcgag cccagaggcc ccaccatcaa gccttgcccc      660

ccttgcaaat gccctgcccc caatctgctg ggcggaccct ccgtgttcat cttcccaccc      720

aagatcaagg acgtgctgat gatcagcctg agccccatcg tgacctgcgt ggtggtggac      780

gtgtccgagg acgaccccga tgtgcagatc agttggttcg tgaacaacgt ggaagtgcac      840

accgcccaga cccagacaca cagagaggac tacaacagca ccctgagagt ggtgtccgcc      900

ctgcccatcc agcaccagga ttggatgagc ggcaaagagt tcaagtgcaa agtgaacaac      960

aaggacctgc cagcccccat cgagcggacc atctctaagc ctaagggcag cgtgcgggct     1020

ccccaggtgt acgtgctgcc tcctccagag gaagagatga ccaagaaaca agtgacactg     1080

acatgcatgg tcaccgactt catgcccgag gacatctacg tggaatggac caacaacggc     1140

aagaccgagc tgaactacaa gaacaccgag cccgtgctgg acagcgacgg cagctacttc     1200

atgtacagca agctgcgggt ggaaaagaaa aactgggtgg aacggaacag ctacagctgc     1260

agcgtggtgc acgagggcct gcacaatcac cacaccacca agagcttcag ccggacccct     1320

ggcaag                                                                1326


<210>  242
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15285_497A-M005-F02-mIgG2aLambda_Light Chain

<400>  242
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctt caacatcggc agccacttcg tgtactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac aagaacaacc agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggccctgtt      300

tttggcggag gcaccaagct gacagtgcta ggccagccca agagcagccc tagcgtgacc      360

ctgttccctc caagcagcga ggaactggaa acaaacaagg ccaccctcgt gtgcaccatc      420

accgacttct accccggcgt cgtgaccgtg gactggaagg tggacggcac cccagtgacc      480

cagggcatgg aaaccaccca gcccagcaag cagagcaaca acaagtacat ggccagcagc      540

tacctgaccc tgaccgccag agcctgggag agacacagct cctacagctg ccaagtgacc      600

cacgagggcc acaccgtgga aaagagcctg agcagagccg actgcagc                   648


<210>  243
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_VH

<400>  243

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gln Leu Gly Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  244
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_HCDR1

<400>  244

Ser Tyr Gly Met His 
1               5   


<210>  245
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_HCDR2

<400>  245

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  246
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_HCDR3

<400>  246

Gly Arg Gln Leu Gly Ser 
1               5       


<210>  247
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_VL

<400>  247

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  248
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_LCDR1

<400>  248

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_LCDR2

<400>  249

Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210>  250
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_LCDR3

<400>  250

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  251
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_VH

<400>  251
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atctctggca gcggcggcag cacatattac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagaggcaga      300

cagctcggct cttggggaca gggaacactg gttacagtgt cctca                      345


<210>  252
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_VL

<400>  252
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgtactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac ggcaacaaca acagacccag cggcgtgccc      180

gatagattca gcggctctaa gtctggcaca agcgccagcc tggccatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggctgggtt      300

ttcggcggag gcaccaaact gacagtgcta                                       330


<210>  253
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_Heavy Chain

<400>  253

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gln Leu Gly Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
    210                 215                 220                 


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
            260                 265                 270         


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
    290                 295                 300                 


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
305                 310                 315                 320 


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
                325                 330                 335     


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
            340                 345                 350         


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
        355                 360                 365             


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
    370                 375                 380                 


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
                405                 410                 415     


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445 


<210>  254
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_Light Chain

<400>  254

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  255
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_Heavy Chain

<400>  255
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atctctggca gcggcggcag cacatattac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagaggcaga      300

cagctcggct cttggggaca gggaacactg gttacagtgt cctcagccaa gaccaccgcc      360

cccagcgtgt accctctggc tcctgtgtgt ggcgatacca ccggcagctc tgtgaccctg      420

ggctgcctcg tgaagggcta cttccctgag ccagtgaccc tgacctggaa cagcggctct      480

ctgtctagcg gcgtgcacac ctttccagcc gtgctgcaga gcgacctgta caccctgagc      540

agcagcgtga ccgtgaccag cagcacatgg cccagccaga gcatcacctg taacgtggcc      600

caccctgcca gctccaccaa ggtggacaag aagatcgagc ccagaggccc caccatcaag      660

ccttgccccc cttgcaaatg ccctgccccc aatctgctgg gcggaccctc cgtgttcatc      720

ttcccaccca agatcaagga cgtgctgatg atcagcctga gccccatcgt gacctgcgtg      780

gtggtggacg tgtccgagga cgaccccgat gtgcagatca gttggttcgt gaacaacgtg      840

gaagtgcaca ccgcccagac ccagacacac agagaggact acaacagcac cctgagagtg      900

gtgtccgccc tgcccatcca gcaccaggat tggatgagcg gcaaagagtt caagtgcaaa      960

gtgaacaaca aggacctgcc agcccccatc gagcggacca tctctaagcc taagggcagc     1020

gtgcgggctc cccaggtgta cgtgctgcct cctccagagg aagagatgac caagaaacaa     1080

gtgacactga catgcatggt caccgacttc atgcccgagg acatctacgt ggaatggacc     1140

aacaacggca agaccgagct gaactacaag aacaccgagc ccgtgctgga cagcgacggc     1200

agctacttca tgtacagcaa gctgcgggtg gaaaagaaaa actgggtgga acggaacagc     1260

tacagctgca gcgtggtgca cgagggcctg cacaatcacc acaccaccaa gagcttcagc     1320

cggacccctg gcaag                                                      1335


<210>  256
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-15286_497A-M005-E07-mIgG2aLambda_Light Chain

<400>  256
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgtactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac ggcaacaaca acagacccag cggcgtgccc      180

gatagattca gcggctctaa gtctggcaca agcgccagcc tggccatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg attctctgaa cggctgggtt      300

ttcggcggag gcaccaaact gacagtgcta ggccagccca agagcagccc tagcgtgacc      360

ctgttccctc caagcagcga ggaactggaa acaaacaagg ccaccctcgt gtgcaccatc      420

accgacttct accccggcgt cgtgaccgtg gactggaagg tggacggcac cccagtgacc      480

cagggcatgg aaaccaccca gcccagcaag cagagcaaca acaagtacat ggccagcagc      540

tacctgaccc tgaccgccag agcctgggag agacacagct cctacagctg ccaagtgacc      600

cacgagggcc acaccgtgga aaagagcctg agcagagccg actgcagc                   648


<210>  257
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_VH

<400>  257

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Ala Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Ala Gly Thr Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  258
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_HCDR1

<400>  258

Ser Tyr Ser Met Asn 
1               5   


<210>  259
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_HCDR2

<400>  259

Gly Val Ser Trp Ala Gly Ser Arg Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  260
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_HCDR3

<400>  260

Ala Ala Ala Gly Thr Arg Gly Phe Asp Tyr 
1               5                   10  


<210>  261
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_VL

<400>  261

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ile Ser 
                85                  90                  95      


Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  262
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_LCDR1

<400>  262

Ser Gly Ser Ser Ser Asn Ile Gly Ser His Ile Val Asn 
1               5                   10              


<210>  263
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_LCDR2

<400>  263

Gly Asn Thr Asn Arg Pro Ser 
1               5           


<210>  264
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_LCDR3

<400>  264

Ser Ser Tyr Thr Ser Ile Ser Thr Leu Val 
1               5                   10  


<210>  265
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_VH

<400>  265
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacagca tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtttcaggc gtgtcctggg ccggcagcag aacccactat      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagagctgcc      300

gccggaacca gaggctttga ttattggggc cagggcaccc tggtcaccgt ttcttca         357


<210>  266
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_HCDR1

<400>  266
agctacagca tgaac                                                        15


<210>  267
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_HCDR2

<400>  267
ggcgtgtcct gggccggcag cagaacccac tatgccgaca gcgtgaaggg c                51


<210>  268
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_HCDR3

<400>  268
gctgccgccg gaaccagagg ctttgattat                                        30


<210>  269
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_VL

<400>  269
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caatatcggc agccacatcg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac ggcaacacca acagacccag cggcgtgccc      180

gatagatttt ccggctctaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctactgcagc agctacacca gcatcagcac cctggttttt      300

ggcggaggca ccaagctgac agtgcta                                          327


<210>  270
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_LCDR1

<400>  270
agcggcagca gctccaatat cggcagccac atcgtgaac                              39


<210>  271
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_LCDR2

<400>  271
ggcaacacca acagacccag c                                                 21


<210>  272
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_LCDR3

<400>  272
agcagctaca ccagcatcag caccctggtt                                        30


<210>  273
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_Heavy Chain

<400>  273

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Ala Gly Ser Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Ala Gly Thr Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  274
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-16966_15291-deglyco-hIgG1Lambda_Light Chain

<400>  274

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ile Ser 
                85                  90                  95      


Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  275
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_VH

<400>  275

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ile Gly Arg Arg Pro Gly Leu Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  276
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_HCDR1

<400>  276

Ser Tyr Ala Met His 
1               5   


<210>  277
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_HCDR2

<400>  277

Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  278
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_HCDR3

<400>  278

Gly Gly Ile Gly Arg Arg Pro Gly Leu Glu Tyr 
1               5                   10      


<210>  279
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_VL

<400>  279

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly Thr Gly Ile 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  280
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_LCDR1

<400>  280

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  281
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_LCDR2

<400>  281

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  282
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_LCDR3

<400>  282

Gln Thr Trp Gly Thr Gly Ile Arg Val 
1               5                   


<210>  283
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_VH

<400>  283
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagg agctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtctctctt attagttggg atggtggtag cacctactat      180

gcagactctg tgaagggtcg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagggggt      300

atagggcgtc gtcctgggct tgagtactgg ggccaaggta ccctggtcac cgtgagttca      360


<210>  284
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_HCDR1

<400>  284
agctatgcta tgcac                                                        15


<210>  285
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_HCDR2

<400>  285
cttattagtt gggatggtgg tagcacctac tatgcagact ctgtgaaggg t                51


<210>  286
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_HCDR3

<400>  286
gggggtatag ggcgtcgtcc tgggcttgag tac                                    33


<210>  287
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_VL

<400>  287
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgctctg gaagcagctc caacattgga aataattatg tttcctggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtcag acctggggca ctggcattcg ggtgttcggc      300

ggaggaacca agctgacggt ccta                                             324


<210>  288
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_LCDR1

<400>  288
tctggaagca gctccaacat tggaaataat tatgtttcc                              39


<210>  289
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_LCDR2

<400>  289
ggtaacagca atcggccctc a                                                 21


<210>  290
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_LCDR3

<400>  290
cagacctggg gcactggcat tcgggtg                                           27


<210>  291
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_Heavy Chain

<400>  291

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ile Gly Arg Arg Pro Gly Leu Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  292
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17575_497A-M181-C17-1-hIgG1Lambda_Light Chain

<400>  292

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly Thr Gly Ile 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  293
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_VH

<400>  293

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Pro Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  294
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_HCDR1

<400>  294

Ser Tyr Ala Met Ser 
1               5   


<210>  295
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_HCDR2

<400>  295

Arg Ile Arg Ser Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  296
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_HCDR3

<400>  296

Pro Leu Asp Ser 
1               


<210>  297
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_VL

<400>  297

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Leu 
                85                  90                  95      


Ser Ala Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  298
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_LCDR1

<400>  298

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  299
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_LCDR2

<400>  299

Arg Asn Asn Gln Arg Ser Ser 
1               5           


<210>  300
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_LCDR3

<400>  300

Gln Ser Tyr Asp Asn Ser Leu Ser Ala Ser Val 
1               5                   10      


<210>  301
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_VH

<400>  301
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attagaagca aagctaacag ttacgcgaca      180

gcatatgctg cgtcggtgaa aggcaggttc accatctcca gagacaattc caagaacacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacactg ccgtgtatta ctgtacgagg      300

cccttggact cctggggcca aggtaccctg gtcaccgtga gttca                      345


<210>  302
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_HCDR1

<400>  302
agctatgcca tgagc                                                        15


<210>  303
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_HCDR2

<400>  303
cgtattagaa gcaaagctaa cagttacgcg acagcatatg ctgcgtcggt gaaaggc          57


<210>  304
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_HCDR3

<400>  304
cccttggact cc                                                           12


<210>  305
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_VL

<400>  305
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat agaaataatc agcggtcctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgccag tcctatgaca acagcctgag tgcttcggtg      300

ttcggcggag gaaccaagct gacggtccta                                       330


<210>  306
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_LCDR1

<400>  306
tctggaagca gctccaacat cggaaataat gctgtaaac                              39


<210>  307
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_LCDR2

<400>  307
agaaataatc agcggtcctc a                                                 21


<210>  308
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_LCDR3

<400>  308
cagtcctatg acaacagcct gagtgcttcg gtg                                    33


<210>  309
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_Heavy Chain

<400>  309

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Pro Leu Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  310
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17576_497A-M136-O21-1-hIgG1Lambda_Light Chain

<400>  310

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Leu 
                85                  90                  95      


Ser Ala Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  311
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_VH

<400>  311

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Leu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Pro Tyr Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  312
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_HCDR1

<400>  312

Asn Ala Trp Met Ser 
1               5   


<210>  313
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_HCDR2

<400>  313

Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Ser Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  314
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_HCDR3

<400>  314

Gly Leu Pro Tyr Gly Tyr 
1               5       


<210>  315
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_VL

<400>  315

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Lys Ala Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  316
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_LCDR1

<400>  316

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  317
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_LCDR2

<400>  317

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  318
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_LCDR3

<400>  318

Ala Ala Trp Asp Asp Ser Leu Lys Ala Leu Val 
1               5                   10      


<210>  319
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_VH

<400>  319
gaggtgcagc tgttggagtc tgggggaggc ttgttacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcagtt atatcatatg atggaagaaa taaatactct      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gaggggcctc      300

ccttatggct actggggcca aggtaccctg gtcaccgtga gttca                      345


<210>  320
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_HCDR1

<400>  320
aacgcctgga tgagc                                                        15


<210>  321
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_HCDR2

<400>  321
gttatatcat atgatggaag aaataaatac tctgcagact ccgtgaaggg c                51


<210>  322
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_HCDR3

<400>  322
ggcctccctt atggctac                                                     18


<210>  323
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_VL

<400>  323
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgct gcatgggatg acagtctgaa ggctctggta      300

ttcggcggag gaaccaagct gacggtccta                                       330


<210>  324
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_LCDR1

<400>  324
tctggaagca gctccaacat cggaagtaat actgtaaac                              39


<210>  325
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_LCDR2

<400>  325
aggaataatc agcggccctc a                                                 21


<210>  326
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_LCDR3

<400>  326
gctgcatggg atgacagtct gaaggctctg gta                                    33


<210>  327
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_Heavy Chain

<400>  327

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Leu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Pro Tyr Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  328
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17577_497A-M178-K09-1-hIgG1Lambda_Light Chain

<400>  328

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Lys Ala Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  329
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_VH

<400>  329

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  330
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_HCDR1

<400>  330

Asn Ala Trp Met Ser 
1               5   


<210>  331
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_HCDR2

<400>  331

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  332
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_HCDR3

<400>  332

Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Asn 
1               5                   10          


<210>  333
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_VL

<400>  333

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  334
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_LCDR1

<400>  334

Ser Gly Ser Ser Ser Asn Ile Gly Ser His Thr Val Asn 
1               5                   10              


<210>  335
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_LCDR2

<400>  335

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  336
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_LCDR3

<400>  336

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  337
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_VH

<400>  337
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctctggt attaattgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgt taggacgtat      300

agtgggcact acggacccta ctttgacaac tggggccaag gtaccctggt caccgtgagt      360

tca                                                                    363


<210>  338
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_HCDR1

<400>  338
aacgcctgga tgagc                                                        15


<210>  339
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_HCDR2

<400>  339
ggtattaatt ggaatggtgg tagcacaggt tatgcagact ctgtgaaggg c                51


<210>  340
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_HCDR3

<400>  340
acgtatagtg ggcactacgg accctacttt gacaac                                 36


<210>  341
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_VL

<400>  341
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtcatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg      300

ttcggcggag gaaccaagct gacggtccta                                       330


<210>  342
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_LCDR1

<400>  342
tctggaagca gctccaacat cggaagtcat actgtaaac                              39


<210>  343
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_LCDR2

<400>  343
aggaataatc agcggccctc a                                                 21


<210>  344
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_LCDR3

<400>  344
gcagcatggg atgacagcct gaatggttgg gtg                                    33


<210>  345
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_Heavy Chain

<400>  345

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  346
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17578_497A-M128-B10-1-hIgG1Lambda_Light Chain

<400>  346

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  347
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_VH

<400>  347

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Thr Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Arg Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Gly Tyr Pro Asp Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  348
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_HCDR1

<400>  348

Thr Tyr Trp Met Thr 
1               5   


<210>  349
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_HCDR2

<400>  349

Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Arg 
    


<210>  350
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_HCDR3

<400>  350

Tyr Ser Gly Tyr Pro Asp Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  351
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_VL

<400>  351

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Trp Ser Asn Ile Gly Asn Asp 
            20                  25                  30          


Asn Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser Leu 
                85                  90                  95      


Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  352
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_LCDR1

<400>  352

Ser Gly Ser Trp Ser Asn Ile Gly Asn Asp Asn Val Tyr 
1               5                   10              


<210>  353
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_LCDR2

<400>  353

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  354
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_LCDR3

<400>  354

Gln Ser Tyr Asp Arg Ser Leu Ser Gly Ser Val 
1               5                   10      


<210>  355
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_VH

<400>  355
gaggtgcaac tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgtt acatattgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtatcgggt gttagttgga atggcagtag gacgcactat      180

gtggactccg tgaagcgccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagatatagt      300

ggctaccctg actactacgg tatggacgtc tggggccaag gtaccctggt caccgtgagt      360

tca                                                                    363


<210>  356
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_HCDR1

<400>  356
acatattgga tgacc                                                        15


<210>  357
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_HCDR2

<400>  357
ggtgttagtt ggaatggcag taggacgcac tatgtggact ccgtgaagcg c                51


<210>  358
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_HCDR3

<400>  358
tatagtggct accctgacta ctacggtatg gacgtc                                 36


<210>  359
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_VL

<400>  359
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagctggtc caacatcgga aatgataatg tatactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgccag tcttatgaca ggagcctgag tggttcggtg      300

ttcggcggag gaaccaagct gacggtccta                                       330


<210>  360
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_LCDR1

<400>  360
tctggaagct ggtccaacat cggaaatgat aatgtatac                              39


<210>  361
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_LCDR2

<400>  361
aggaataatc agcggccctc a                                                 21


<210>  362
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_LCDR3

<400>  362
cagtcttatg acaggagcct gagtggttcg gtg                                    33


<210>  363
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_Heavy Chain

<400>  363

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Thr Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Arg Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Gly Tyr Pro Asp Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  364
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17579_497A-M180-K04-1-hIgG1Lambda_Light Chain

<400>  364

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Trp Ser Asn Ile Gly Asn Asp 
            20                  25                  30          


Asn Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser Leu 
                85                  90                  95      


Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  365
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_VH

<400>  365

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ser Tyr Asn Ser Gly Trp Tyr Ala Val Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  366
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_HCDR1

<400>  366

Ser Tyr Gly Met His 
1               5   


<210>  367
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_HCDR2

<400>  367

Gly Val Ser Trp Asn Gly Ser Arg Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  368
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_HCDR3

<400>  368

Gly Ser Tyr Asn Ser Gly Trp Tyr Ala Val Ser 
1               5                   10      


<210>  369
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_VL

<400>  369

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Val Thr Asp 
                85                  90                  95      


Asn Leu Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  370
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_LCDR1

<400>  370

Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr Pro Val Asn 
1               5                   10              


<210>  371
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_LCDR2

<400>  371

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  372
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_LCDR3

<400>  372

Ser Ser Tyr Ser Val Thr Asp Asn Leu Ile 
1               5                   10  


<210>  373
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_VH

<400>  373
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtatcgggt gttagttgga atggcagtag gacgcgctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtac tagagggtca      300

tataatagtg gctggtacgc ggtctcctgg ggccaaggta ccctggtcac cgtgagttca      360


<210>  374
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_HCDR1

<400>  374
agctatggca tgcac                                                        15


<210>  375
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_HCDR2

<400>  375
ggtgttagtt ggaatggcag taggacgcgc tatgcggact ctgtgaaggg c                51


<210>  376
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_HCDR3

<400>  376
gggtcatata atagtggctg gtacgcggtc tcc                                    33


<210>  377
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_VL

<400>  377
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ctgggcagag ggtcaccatc       60

tcttgttctg gaagcagttc caacatcggg agttatcctg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgcagc tcatattctg tcaccgacaa tttgatattc      300

ggcggaggaa ccaagctgac ggtccta                                          327


<210>  378
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_LCDR1

<400>  378
tctggaagca gttccaacat cgggagttat cctgtaaac                              39


<210>  379
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_LCDR2

<400>  379
aggaataatc agcggccctc a                                                 21


<210>  380
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_LCDR3

<400>  380
agctcatatt ctgtcaccga caatttgata                                        30


<210>  381
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_Heavy Chain

<400>  381

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Asn Gly Ser Arg Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ser Tyr Asn Ser Gly Trp Tyr Ala Val Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  382
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17580_497A-M193-A08-1-hIgG1Lambda_Light Chain

<400>  382

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Val Thr Asp 
                85                  90                  95      


Asn Leu Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  383
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_VH

<400>  383

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Phe Asp Thr Arg Gly Phe Tyr Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  384
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_HCDR1

<400>  384

Asn Tyr Arg Met Thr 
1               5   


<210>  385
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_HCDR2

<400>  385

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  386
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_HCDR3

<400>  386

Gly Arg Phe Asp Thr Arg Gly Phe Tyr Gly Phe Asp Tyr 
1               5                   10              


<210>  387
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_VL

<400>  387

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser His Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  388
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_LCDR1

<400>  388

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  389
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_LCDR2

<400>  389

Ser His Asn Gln Arg Pro Ser 
1               5           


<210>  390
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_LCDR3

<400>  390

Ser Ala Trp Asp Ser Ser Leu Ser Ala Trp Val 
1               5                   10      


<210>  391
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_VH

<400>  391
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aattatagga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctctggt attaattgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc cagagggcgc      300

tttgatacta ggggttttta cggctttgac tactggggcc aaggtaccct ggtcaccgtg      360

agttca                                                                 366


<210>  392
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_HCDR1

<400>  392
aattatagga tgacc                                                        15


<210>  393
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_HCDR2

<400>  393
ggtattaatt ggaatggtgg tagcacaggt tatgcagact ctgtgaaggg c                51


<210>  394
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_HCDR3

<400>  394
gggcgctttg atactagggg tttttacggc tttgactac                              39


<210>  395
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_VL

<400>  395
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatagtcata atcagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgc tcagcatggg acagcagcct cagtgcttgg      300

gtgttcggcg gaggaaccaa gctgacggtc cta                                   333


<210>  396
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_LCDR1

<400>  396
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210>  397
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_LCDR2

<400>  397
agtcataatc agcggccctc a                                                 21


<210>  398
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_LCDR3

<400>  398
tcagcatggg acagcagcct cagtgcttgg gtg                                    33


<210>  399
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_Heavy Chain

<400>  399

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Phe Asp Thr Arg Gly Phe Tyr Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  400
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-17581_497A-M177-L03-1-hIgG1Lambda_Light Chain

<400>  400

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser His Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  401
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_VH

<400>  401

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Ser Gly Ser Lys Gly Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Asn Tyr Tyr Val Gly Tyr His Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  402
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_HCDR1

<400>  402

Ser Tyr Ala Met Ser 
1               5   


<210>  403
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_HCDR2

<400>  403

Gly Ile Arg Trp Asn Ser Gly Ser Lys Gly Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  404
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_HCDR3

<400>  404

Ser Gly Asn Tyr Tyr Val Gly Tyr His Gly Met Asp Val 
1               5                   10              


<210>  405
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_VL

<400>  405

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Asn Thr 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  406
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_LCDR1

<400>  406

Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr Phe Val Ser 
1               5                   10              


<210>  407
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_LCDR2

<400>  407

Thr Asn Asn Gln Arg Pro Ser 
1               5           


<210>  408
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_LCDR3

<400>  408

Glu Thr Trp Asp Ser Asn Thr Arg Val 
1               5                   


<210>  409
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_VH

<400>  409
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccggc atcagatgga acagcggctc taagggctat      180

gccggctctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gcggagcggc      300

aattactacg tgggctacca cggcatggat gtgtggggac agggaaccct ggttaccgtt      360

tcttca                                                                 366


<210>  410
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_HCDR1

<400>  410
agctacgcca tgagc                                                        15


<210>  411
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_HCDR2

<400>  411
ggcatcagat ggaacagcgg ctctaagggc tatgccggct ctgtgaaggg c                51


<210>  412
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_HCDR3

<400>  412
agcggcaatt actacgtggg ctaccacggc atggatgtg                              39


<210>  413
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_VL

<400>  413
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcggcaacag caacatcggc acctacttcg tgtcctggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac accaacaacc agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctactgcgag acatgggaca gcaacaccag agtgtttggc      300

ggaggcacca agctgacagt gcta                                             324


<210>  414
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_LCDR1

<400>  414
agcggcggca acagcaacat cggcacctac ttcgtgtcc                              39


<210>  415
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_LCDR2

<400>  415
accaacaacc agcggcctag c                                                 21


<210>  416
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_LCDR3

<400>  416
gagacatggg acagcaacac cagagtg                                           27


<210>  417
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_Heavy 
       Chain

<400>  417

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Ser Gly Ser Lys Gly Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Asn Tyr Tyr Val Gly Tyr His Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  418
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18205_004-F10_497A-M296-L12+497A-M326-O09-hIgG1Lambda_Light 
       Chain

<400>  418

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Asn Thr 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  419
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_VH

<400>  419

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  420
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_HCDR1

<400>  420

His Tyr Gly Met His 
1               5   


<210>  421
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_HCDR2

<400>  421

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  422
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_HCDR3

<400>  422

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  423
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_VL

<400>  423

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  424
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_LCDR1

<400>  424

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  425
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_LCDR2

<400>  425

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  426
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_LCDR3

<400>  426

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  427
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_VH

<400>  427
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  428
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_HCDR1

<400>  428
cactatggca tgcac                                                        15


<210>  429
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_HCDR2

<400>  429
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  430
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_HCDR3

<400>  430
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  431
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_VL

<400>  431
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  432
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_LCDR1

<400>  432
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  433
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_LCDR2

<400>  433
accaacaaca gacggcccag c                                                 21


<210>  434
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_LCDR3

<400>  434
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  435
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_Heavy 
       Chain

<400>  435

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  436
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_Light 
       Chain

<400>  436

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  437
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_VH

<400>  437

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Thr Gly Asn Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  438
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_HCDR1

<400>  438

Asn Ala Trp Met Ser 
1               5   


<210>  439
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_HCDR2

<400>  439

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  440
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_HCDR3

<400>  440

Thr Tyr Thr Gly Asn Tyr Gly Pro Tyr Phe Asp Tyr 
1               5                   10          


<210>  441
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_VL

<400>  441

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  442
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_LCDR1

<400>  442

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  443
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_LCDR2

<400>  443

Lys Asn Asn Gln Arg Pro Ser 
1               5           


<210>  444
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_LCDR3

<400>  444

Ala Ala Trp Asp Asp Ser Leu Arg Gly Trp Val 
1               5                   10      


<210>  445
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_VH

<400>  445
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc aatgcctgga tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc cagaacctac      300

accggcaact acggccccta cttcgattat tggggccagg gcacactggt caccgtttct      360

tca                                                                    363


<210>  446
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_HCDR1

<400>  446
aatgcctgga tgagc                                                        15


<210>  447
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_HCDR2

<400>  447
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  448
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_HCDR3

<400>  448
acctacaccg gcaactacgg cccctacttc gattat                                 36


<210>  449
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_VL

<400>  449
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaagaaca accagcggcc tagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgattctct gagaggctgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  450
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_LCDR1

<400>  450
accggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  451
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_LCDR2

<400>  451
aagaacaacc agcggcctag c                                                 21


<210>  452
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_LCDR3

<400>  452
gccgcctggg atgattctct gagaggctgg gtt                                    33


<210>  453
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_Heavy 
       Chain

<400>  453

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Thr Gly Asn Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  454
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18207_001-B08_497A-M301-B18+497A-M316-D16-hIgG1Lambda_Light 
       Chain

<400>  454

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Lys Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  455
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_VH

<400>  455

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  456
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_HCDR1

<400>  456

Ser Ala Trp Met Ser 
1               5   


<210>  457
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_HCDR2

<400>  457

Gly Ile Ser Trp Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  458
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_HCDR3

<400>  458

Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Tyr 
1               5                   10          


<210>  459
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_VL

<400>  459

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  460
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_LCDR1

<400>  460

Ser Gly Ser Ser Ser Asn Ile Gly Ser His Thr Val Asn 
1               5                   10              


<210>  461
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_LCDR2

<400>  461

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  462
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_LCDR3

<400>  462

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  463
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_VH

<400>  463
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacattttct agcgcctgga tgagctgggt ccgacaggct      120

cctggaaaag gcctggaatg ggtgtccggc atctcttgga gcggcggctc tacaggctat      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc cagaacatac      300

agcggccact acggccccta cttcgattat tggggccagg gcacactggt caccgtttct      360

tca                                                                    363


<210>  464
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_HCDR1

<400>  464
agcgcctgga tgagc                                                        15


<210>  465
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_HCDR2

<400>  465
ggcatctctt ggagcggcgg ctctacaggc tatgccgatt ctgtgaaggg c                51


<210>  466
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_HCDR3

<400>  466
acatacagcg gccactacgg cccctacttc gattat                                 36


<210>  467
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_VL

<400>  467
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtcatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg      300

ttcggcggag gaaccaagct gacggtccta                                       330


<210>  468
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_LCDR1

<400>  468
tctggaagca gctccaacat cggaagtcat actgtaaac                              39


<210>  469
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_LCDR2

<400>  469
aggaataatc agcggccctc a                                                 21


<210>  470
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_LCDR3

<400>  470
gcagcatggg atgacagcct gaatggttgg gtg                                    33


<210>  471
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_Heavy Chain

<400>  471

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  472
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19546_17578-gl33-hIgG1Lambda_Light Chain

<400>  472

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  473
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_VH

<400>  473

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Lys Trp Gly Gly Gly Ser His Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Lys Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  474
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_HCDR1

<400>  474

Ser Tyr Gly Met His 
1               5   


<210>  475
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_HCDR2

<400>  475

Ala Ile Lys Trp Gly Gly Gly Ser His Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  476
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_HCDR3

<400>  476

Gly His His Ser Gly Lys Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  477
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_VL

<400>  477

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  478
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_LCDR1

<400>  478

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  479
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_LCDR2

<400>  479

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  480
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_LCDR3

<400>  480

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  481
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_VH

<400>  481
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc attaagtggg gcggaggctc tcacggctat      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cactctggca aggacggcag attcttcgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  482
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_HCDR1

<400>  482
agctatggca tgcac                                                        15


<210>  483
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_HCDR2

<400>  483
gccattaagt ggggcggagg ctctcacggc tatgccgatt ctgtgaaggg c                51


<210>  484
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_HCDR3

<400>  484
ggccaccact ctggcaagga cggcagattc ttcgactat                              39


<210>  485
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_VL

<400>  485
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  486
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_LCDR1

<400>  486
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  487
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_LCDR2

<400>  487
accaacaaca gacggcccag c                                                 21


<210>  488
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_LCDR3

<400>  488
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  489
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_Heavy Chain

<400>  489

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Lys Trp Gly Gly Gly Ser His Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Lys Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  490
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20950_18206-gl-42-hIgG1wt-Lambda_Light Chain

<400>  490

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  491
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_VH

<400>  491

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Lys Trp Gly Gly Gly Ser His Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Lys Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  492
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_HCDR1

<400>  492

Ser Tyr Gly Met His 
1               5   


<210>  493
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_HCDR2

<400>  493

Ala Ile Lys Trp Gly Gly Gly Ser His Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  494
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_HCDR3

<400>  494

Gly His His Lys Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  495
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_VL

<400>  495

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  496
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_LCDR1

<400>  496

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  497
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_LCDR2

<400>  497

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  498
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_LCDR3

<400>  498

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  499
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_VH

<400>  499
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc attaagtggg gcggaggctc tcacggctat      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacaagggct acgacggcag attcttcgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  500
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_HCDR1

<400>  500
agctatggca tgcac                                                        15


<210>  501
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_HCDR2

<400>  501
gccattaagt ggggcggagg ctctcacggc tatgccgatt ctgtgaaggg c                51


<210>  502
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_HCDR3

<400>  502
ggccaccaca agggctacga cggcagattc ttcgactat                              39


<210>  503
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_VL

<400>  503
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  504
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_LCDR1

<400>  504
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  505
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_LCDR2

<400>  505
accaacaaca gacggcccag c                                                 21


<210>  506
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_LCDR3

<400>  506
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  507
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_Heavy Chain

<400>  507

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Lys Trp Gly Gly Gly Ser His Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Lys Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  508
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20955_18206-gl-47-hIgG1wt-Lambda_Light Chain

<400>  508

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  509
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_VH

<400>  509

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Lys Trp Gly Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Lys Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  510
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_HCDR1

<400>  510

Ser Tyr Gly Met His 
1               5   


<210>  511
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_HCDR2

<400>  511

Ala Ile Lys Trp Gly Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  512
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_HCDR3

<400>  512

Gly His His Ser Gly Lys Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  513
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_VL

<400>  513

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  514
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_LCDR1

<400>  514

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  515
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_LCDR2

<400>  515

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  516
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_LCDR3

<400>  516

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  517
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_VH

<400>  517
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc attaagtggg gcggaggctc tacaggctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cactctggca aggacggcag attcttcgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  518
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_HCDR1

<400>  518
agctatggca tgcac                                                        15


<210>  519
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_HCDR2

<400>  519
gccattaagt ggggcggagg ctctacaggc tacgccgatt ctgtgaaggg c                51


<210>  520
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_HCDR3

<400>  520
ggccaccact ctggcaagga cggcagattc ttcgactat                              39


<210>  521
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_VL

<400>  521
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  522
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_LCDR1

<400>  522
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  523
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_LCDR2

<400>  523
accaacaaca gacggcccag c                                                 21


<210>  524
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_LCDR3

<400>  524
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  525
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_Heavy Chain

<400>  525

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Lys Trp Gly Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Lys Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  526
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-20965_18206-gl-58-hIgG1wt-Lambda_Light Chain

<400>  526

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  527
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_VH

<400>  527

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Gly Ser Thr Gly Tyr Ala Leu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Ser Gly His Tyr Gly Pro Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  528
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_HCDR1

<400>  528

Ser Ala Trp Met Ser 
1               5   


<210>  529
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_HCDR2

<400>  529

Gly Ile Ser Trp Ser Gly Gly Ser Thr Gly Tyr Ala Leu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  530
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_HCDR3

<400>  530

Thr Tyr Ser Gly His Tyr Gly Pro Phe Phe Asp Tyr 
1               5                   10          


<210>  531
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_VL

<400>  531

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  532
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_LCDR1

<400>  532

Ser Gly Ser Ser Ser Asn Ile Gly Ser His Thr Val Asn 
1               5                   10              


<210>  533
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_LCDR2

<400>  533

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  534
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_LCDR3

<400>  534

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  535
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_VH

<400>  535
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacattttct agcgcctgga tgagctgggt ccgacaggct      120

cctggaaaag gcctggaatg ggtgtccggc atctcttgga gcggcggctc tacaggatat      180

gccctgtctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaacatac      300

agcggccact acggcccttt cttcgactat tggggccagg gcacactggt cacagtctct      360

tca                                                                    363


<210>  536
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_HCDR1

<400>  536
agcgcctgga tgagc                                                        15


<210>  537
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_HCDR2

<400>  537
ggcatctctt ggagcggcgg ctctacagga tatgccctgt ctgtgaaggg c                51


<210>  538
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_HCDR3

<400>  538
acatacagcg gccactacgg ccctttcttc gactat                                 36


<210>  539
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_VL

<400>  539
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtcatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg      300

ttcggcggag gaaccaagct gacggtccta                                       330


<210>  540
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_LCDR1

<400>  540
tctggaagca gctccaacat cggaagtcat actgtaaac                              39


<210>  541
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_LCDR2

<400>  541
aggaataatc agcggccctc a                                                 21


<210>  542
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_LCDR3

<400>  542
gcagcatggg atgacagcct gaatggttgg gtg                                    33


<210>  543
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_Heavy Chain

<400>  543

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Gly Ser Thr Gly Tyr Ala Leu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Ser Gly His Tyr Gly Pro Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  544
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21045_17578-gl79-hIgG1-wt-Lambda_Light Chain

<400>  544

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  545
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_VH

<400>  545

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Gly Arg Thr Gly Tyr Ala Leu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  546
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_HCDR1

<400>  546

Ser Ala Trp Met Ser 
1               5   


<210>  547
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_HCDR2

<400>  547

Gly Ile Ser Trp Ser Gly Gly Arg Thr Gly Tyr Ala Leu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  548
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_HCDR3

<400>  548

Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Tyr 
1               5                   10          


<210>  549
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_VL

<400>  549

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  550
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_LCDR1

<400>  550

Ser Gly Ser Ser Ser Asn Ile Gly Ser His Thr Val Asn 
1               5                   10              


<210>  551
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_LCDR2

<400>  551

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  552
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_LCDR3

<400>  552

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  553
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_VH

<400>  553
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacattttct agcgcctgga tgagctgggt ccgacaggct      120

cctggaaaag gcctggaatg ggtgtccggc atctcttgga gcggcggcag aacaggatat      180

gccctgtctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaacatac      300

agcggccact acggccccta cttcgattat tggggccagg gcacactggt caccgtttct      360

tca                                                                    363


<210>  554
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_HCDR1

<400>  554
agcgcctgga tgagc                                                        15


<210>  555
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_HCDR2

<400>  555
ggcatctctt ggagcggcgg cagaacagga tatgccctgt ctgtgaaggg c                51


<210>  556
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_HCDR3

<400>  556
acatacagcg gccactacgg cccctacttc gattat                                 36


<210>  557
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_VL

<400>  557
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtcatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg      300

ttcggcggag gaaccaagct gacggtccta                                       330


<210>  558
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_LCDR1

<400>  558
tctggaagca gctccaacat cggaagtcat actgtaaac                              39


<210>  559
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_LCDR2

<400>  559
aggaataatc agcggccctc a                                                 21


<210>  560
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_LCDR3

<400>  560
gcagcatggg atgacagcct gaatggttgg gtg                                    33


<210>  561
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_Heavy Chain

<400>  561

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Gly Arg Thr Gly Tyr Ala Leu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Ser Gly His Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  562
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21047_17578-gl81-hIgG1-wt-Lambda_Light Chain

<400>  562

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  563
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_VH

<400>  563

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Asn Gly Ser Lys Gly Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Asn Tyr Tyr Tyr Gly Tyr His Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  564
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_HCDR1

<400>  564

Ser Tyr Ala Met Ser 
1               5   


<210>  565
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_HCDR2

<400>  565

Gly Ile Arg Trp Asn Asn Gly Ser Lys Gly Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  566
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_HCDR3

<400>  566

Ser Gly Asn Tyr Tyr Tyr Gly Tyr His Gly Met Asp Val 
1               5                   10              


<210>  567
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_VL

<400>  567

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Asn Thr 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  568
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_LCDR1

<400>  568

Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr Phe Val Ser 
1               5                   10              


<210>  569
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_LCDR2

<400>  569

Thr Asn Asn Gln Arg Pro Ser 
1               5           


<210>  570
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_LCDR3

<400>  570

Glu Thr Trp Asp Ser Asn Thr Arg Val 
1               5                   


<210>  571
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_VH

<400>  571
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccggc atcagatgga acaacggcag caagggctat      180

gccggctctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

aactactact acggctacca cggcatggat gtgtggggcc agggaacact ggttaccgtt      360

tcttca                                                                 366


<210>  572
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_HCDR1

<400>  572
agctacgcca tgagc                                                        15


<210>  573
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_HCDR2

<400>  573
ggcatcagat ggaacaacgg cagcaagggc tatgccggct ctgtgaaggg c                51


<210>  574
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_HCDR3

<400>  574
agcggcaact actactacgg ctaccacggc atggatgtg                              39


<210>  575
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_VL

<400>  575
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcggcaacag caacatcggc acctacttcg tgtcctggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac accaacaacc agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctactgcgag acatgggaca gcaacaccag agtgtttggc      300

ggaggcacca agctgacagt gcta                                             324


<210>  576
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_LCDR1

<400>  576
agcggcggca acagcaacat cggcacctac ttcgtgtcc                              39


<210>  577
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_LCDR2

<400>  577
accaacaacc agcggcctag c                                                 21


<210>  578
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_LCDR3

<400>  578
gagacatggg acagcaacac cagagtg                                           27


<210>  579
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_Heavy Chain

<400>  579

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Asn Gly Ser Lys Gly Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Asn Tyr Tyr Tyr Gly Tyr His Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  580
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21181_18205-gl46 -hIgG1-wt-Lambda_Light Chain

<400>  580

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Asn Thr 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  581
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_VH

<400>  581

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Asn Gly Ser Lys Gly Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Asn Glu Tyr Tyr Gly Tyr His Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  582
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_HCDR1

<400>  582

Ser Tyr Ala Met Ser 
1               5   


<210>  583
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_HCDR2

<400>  583

Gly Ile Arg Trp Asn Asn Gly Ser Lys Gly Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  584
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_HCDR3

<400>  584

Ser Gly Asn Glu Tyr Tyr Gly Tyr His Gly Met Asp Val 
1               5                   10              


<210>  585
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_VL

<400>  585

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Asn Thr 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  586
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_LCDR1

<400>  586

Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr Phe Val Ser 
1               5                   10              


<210>  587
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_LCDR2

<400>  587

Thr Asn Asn Gln Arg Pro Ser 
1               5           


<210>  588
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_LCDR3

<400>  588

Glu Thr Trp Asp Ser Asn Thr Arg Val 
1               5                   


<210>  589
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_VH

<400>  589
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccggc atcagatgga acaacggcag caagggctat      180

gccggctctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

aacgagtact acggctacca cggcatggat gtgtggggcc agggaacact ggttaccgtt      360

tcttca                                                                 366


<210>  590
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_HCDR1

<400>  590
agctacgcca tgagc                                                        15


<210>  591
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_HCDR2

<400>  591
ggcatcagat ggaacaacgg cagcaagggc tatgccggct ctgtgaaggg c                51


<210>  592
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_HCDR3

<400>  592
agcggcaacg agtactacgg ctaccacggc atggatgtg                              39


<210>  593
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_VL

<400>  593
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcggcaacag caacatcggc acctacttcg tgtcctggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac accaacaacc agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctactgcgag acatgggaca gcaacaccag agtgtttggc      300

ggaggcacca agctgacagt gcta                                             324


<210>  594
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_LCDR1

<400>  594
agcggcggca acagcaacat cggcacctac ttcgtgtcc                              39


<210>  595
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_LCDR2

<400>  595
accaacaacc agcggcctag c                                                 21


<210>  596
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_LCDR3

<400>  596
gagacatggg acagcaacac cagagtg                                           27


<210>  597
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_Heavy Chain

<400>  597

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Asn Asn Gly Ser Lys Gly Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Asn Glu Tyr Tyr Gly Tyr His Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  598
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21183_18205-gl48 -hIgG1-wt-Lambda_Light Chain

<400>  598

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Tyr 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Asn Thr 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  599
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_VH

<400>  599

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  600
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_HCDR1

<400>  600

Ser Tyr Gly Met His 
1               5   


<210>  601
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_HCDR2

<400>  601

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  602
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_HCDR3

<400>  602

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  603
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_VL

<400>  603

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  604
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_LCDR1

<400>  604

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  605
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_LCDR2

<400>  605

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  606
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_LCDR3

<400>  606

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  607
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_VH

<400>  607
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  608
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_HCDR1

<400>  608
agctatggca tgcac                                                        15


<210>  609
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_HCDR2

<400>  609
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  610
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_HCDR3

<400>  610
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  611
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_VL

<400>  611
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  612
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_LCDR1

<400>  612
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  613
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_LCDR2

<400>  613
accaacaaca gacggcccag c                                                 21


<210>  614
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_LCDR3

<400>  614
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  615
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_Heavy Chain

<400>  615

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  616
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_Light Chain

<400>  616

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  617
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_VH

<400>  617

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  618
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_HCDR1

<400>  618

Ser Tyr Gly Met His 
1               5   


<210>  619
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_HCDR2

<400>  619

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  620
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_HCDR3

<400>  620

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  621
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_VL

<400>  621

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  622
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_LCDR1

<400>  622

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  623
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_LCDR2

<400>  623

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  624
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_LCDR3

<400>  624

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  625
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_VH

<400>  625
gaggtgcagc tgctggaatc tggcggagga ttggttcagc ctggcggctc tctgagactg       60

tcttgtgccg cttccggctt caccttctcc agctacggaa tgcactgggt ccgacaggcc      120

cctggcaaag gattggaatg ggtgtccgcc atcaactgga acggcggctc taccggctac      180

gccgattctg tgaagggcag attcaccatc agccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc tagaggccac      300

cactctggct acgacggcag attcttcgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  626
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_HCDR1

<400>  626
agctacggaa tgcac                                                        15


<210>  627
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_HCDR2

<400>  627
gccatcaact ggaacggcgg ctctaccggc tacgccgatt ctgtgaaggg c                51


<210>  628
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_HCDR3

<400>  628
ggccaccact ctggctacga cggcagattc ttcgactat                              39


<210>  629
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_VL

<400>  629
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  630
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_LCDR1

<400>  630
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  631
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_LCDR2

<400>  631
accaacaaca gacggcccag c                                                 21


<210>  632
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_LCDR3

<400>  632
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  633
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_Heavy Chain

<400>  633

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  634
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1wtlambda_Light Chain

<400>  634

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  635

<400>  635
000

<210>  636

<400>  636
000

<210>  637

<400>  637
000

<210>  638

<400>  638
000

<210>  639

<400>  639
000

<210>  640

<400>  640
000

<210>  641

<400>  641
000

<210>  642

<400>  642
000

<210>  643

<400>  643
000

<210>  644

<400>  644
000

<210>  645

<400>  645
000

<210>  646

<400>  646
000

<210>  647

<400>  647
000

<210>  648

<400>  648
000

<210>  649

<400>  649
000

<210>  650

<400>  650
000

<210>  651

<400>  651
000

<210>  652

<400>  652
000

<210>  653

<400>  653
000

<210>  654

<400>  654
000

<210>  655

<400>  655
000

<210>  656

<400>  656
000

<210>  657

<400>  657
000

<210>  658

<400>  658
000

<210>  659

<400>  659
000

<210>  660
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_VH_PRT

<400>  660

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  661
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HCDR1_PRT

<400>  661

Ser Tyr Gly Met His 
1               5   


<210>  662
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HCDR2_PRT

<400>  662

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  663
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HCDR3_PRT

<400>  663

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  664
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_VL_PRT

<400>  664

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  665
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LCDR1_PRT

<400>  665

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  666
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LCDR2_PRT

<400>  666

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  667
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LCDR3_PRT

<400>  667

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  668
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_VH_DNA

<400>  668
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  669
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HCDR1_DNA

<400>  669
agctatggca tgcac                                                        15


<210>  670
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HCDR2_DNA

<400>  670
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  671
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HCDR3_DNA

<400>  671
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  672
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_VL_DNA

<400>  672
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  673
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LCDR1_DNA

<400>  673
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  674
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LCDR2_DNA

<400>  674
accaacaaca gacggcccag c                                                 21


<210>  675
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LCDR3_DNA

<400>  675
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  676
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HC_PRT

<400>  676

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  677
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LC_PRT

<400>  677

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  678
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_HC_DNA

<400>  678
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggcaag                               1356


<210>  679
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29596_18206-gl13-gl14-hIgG1wtLambda_LC_DNA

<400>  679
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  680
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_VH_PRT

<400>  680

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  681
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HCDR1_PRT

<400>  681

Ser Tyr Gly Met His 
1               5   


<210>  682
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HCDR2_PRT

<400>  682

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  683
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HCDR3_PRT

<400>  683

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  684
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_VL_PRT

<400>  684

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  685
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LCDR1_PRT

<400>  685

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  686
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LCDR2_PRT

<400>  686

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  687
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LCDR3_PRT

<400>  687

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  688
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_VH_DNA

<400>  688
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  689
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HCDR1_DNA

<400>  689
agctatggca tgcac                                                        15


<210>  690
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HCDR2_DNA

<400>  690
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  691
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HCDR3_DNA

<400>  691
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  692
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_VL_DNA

<400>  692
cagtctgttc tgacacagcc tccatctgct agcggagccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  693
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LCDR1_DNA

<400>  693
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  694
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LCDR2_DNA

<400>  694
accaacaaca gacggcccag c                                                 21


<210>  695
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LCDR3_DNA

<400>  695
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  696
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HC_PRT

<400>  696

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  697
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LC_PRT

<400>  697

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  698
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_HC_DNA

<400>  698
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggcaag                               1356


<210>  699
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29597_18206-gl11-gl25-hIgG1wtLambda_LC_DNA

<400>  699
cagtctgttc tgacacagcc tccatctgct agcggagccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  700
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_HC_DNA

<400>  700
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  701
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18206_002-F01_497A-M281-P02+497A-M317-O07-hIgG1Lambda_LC_DNA

<400>  701
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  702
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_VH_PRT

<400>  702

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  703
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HCDR1_PRT

<400>  703

His Tyr Gly Met His 
1               5   


<210>  704
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HCDR2_PRT

<400>  704

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  705
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HCDR3_PRT

<400>  705

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  706
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_VL_PRT

<400>  706

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  707
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LCDR1_PRT

<400>  707

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  708
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LCDR2_PRT

<400>  708

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  709
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LCDR3_PRT

<400>  709

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  710
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_VH_DNA

<400>  710
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  711
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HCDR1_DNA

<400>  711
cactatggca tgcac                                                        15


<210>  712
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HCDR2_DNA

<400>  712
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  713
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HCDR3_DNA

<400>  713
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  714
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_VL_DNA

<400>  714
cagtctgttc tgacacagcc tccatccgtg tctggcacac ctggccagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggctc taagagcggc accagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  715
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LCDR1_DNA

<400>  715
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  716
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LCDR2_DNA

<400>  716
accaacaaca gacggcccag c                                                 21


<210>  717
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LCDR3_DNA

<400>  717
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  718
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HC_PRT

<400>  718

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  719
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LC_PRT

<400>  719

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  720
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_HC_DNA

<400>  720
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  721
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18429_18206-gl10-hIgG1Lambda_LC_DNA

<400>  721
cagtctgttc tgacacagcc tccatccgtg tctggcacac ctggccagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggctc taagagcggc accagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  722
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_VH_PRT

<400>  722

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  723
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HCDR1_PRT

<400>  723

His Tyr Gly Met His 
1               5   


<210>  724
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HCDR2_PRT

<400>  724

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  725
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HCDR3_PRT

<400>  725

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  726
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_VL_PRT

<400>  726

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  727
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LCDR1_PRT

<400>  727

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  728
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LCDR2_PRT

<400>  728

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  729
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LCDR3_PRT

<400>  729

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  730
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_VH_DNA

<400>  730
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  731
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HCDR1_DNA

<400>  731
cactatggca tgcac                                                        15


<210>  732
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HCDR2_DNA

<400>  732
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  733
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HCDR3_DNA

<400>  733
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  734
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_VL_DNA

<400>  734
cagtctgttc tgacacagcc tccatctgct agcggagccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  735
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LCDR1_DNA

<400>  735
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  736
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LCDR2_DNA

<400>  736
accaacaaca gacggcccag c                                                 21


<210>  737
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LCDR3_DNA

<400>  737
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  738
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HC_PRT

<400>  738

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  739
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LC_PRT

<400>  739

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  740
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_HC_DNA

<400>  740
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  741
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18430_18206-gl11-hIgG1Lambda_LC_DNA

<400>  741
cagtctgttc tgacacagcc tccatctgct agcggagccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  742
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_VH_PRT

<400>  742

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  743
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HCDR1_PRT

<400>  743

His Tyr Gly Met His 
1               5   


<210>  744
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HCDR2_PRT

<400>  744

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  745
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HCDR3_PRT

<400>  745

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  746
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_VL_PRT

<400>  746

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  747
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LCDR1_PRT

<400>  747

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  748
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LCDR2_PRT

<400>  748

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  749
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LCDR3_PRT

<400>  749

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  750
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_VH_DNA

<400>  750
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  751
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HCDR1_DNA

<400>  751
cactatggca tgcac                                                        15


<210>  752
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HCDR2_DNA

<400>  752
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  753
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HCDR3_DNA

<400>  753
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  754
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_VL_DNA

<400>  754
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  755
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LCDR1_DNA

<400>  755
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  756
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LCDR2_DNA

<400>  756
accaacaaca gacggcccag c                                                 21


<210>  757
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LCDR3_DNA

<400>  757
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  758
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HC_PRT

<400>  758

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  759
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LC_PRT

<400>  759

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  760
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_HC_DNA

<400>  760
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  761
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18432_18206-gl13-hIgG1Lambda_LC_DNA

<400>  761
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  762
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_VH_PRT

<400>  762

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  763
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HCDR1_PRT

<400>  763

Ser Tyr Gly Met His 
1               5   


<210>  764
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HCDR2_PRT

<400>  764

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  765
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HCDR3_PRT

<400>  765

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  766
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_VL_PRT

<400>  766

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  767
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LCDR1_PRT

<400>  767

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  768
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LCDR2_PRT

<400>  768

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  769
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LCDR3_PRT

<400>  769

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  770
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_VH_DNA

<400>  770
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  771
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HCDR1_DNA

<400>  771
agctatggca tgcac                                                        15


<210>  772
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HCDR2_DNA

<400>  772
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  773
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HCDR3_DNA

<400>  773
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  774
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_VL_DNA

<400>  774
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  775
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LCDR1_DNA

<400>  775
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  776
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LCDR2_DNA

<400>  776
accaacaaca gacggcccag c                                                 21


<210>  777
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LCDR3_DNA

<400>  777
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  778
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HC_PRT

<400>  778

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  779
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LC_PRT

<400>  779

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  780
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_HC_DNA

<400>  780
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  781
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18433_18206-gl14-hIgG1Lambda_LC_DNA

<400>  781
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  782
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_VH_PRT

<400>  782

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  783
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HCDR1_PRT

<400>  783

His Tyr Gly Met His 
1               5   


<210>  784
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HCDR2_PRT

<400>  784

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  785
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HCDR3_PRT

<400>  785

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  786
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_VL_PRT

<400>  786

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  787
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LCDR1_PRT

<400>  787

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  788
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LCDR2_PRT

<400>  788

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  789
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LCDR3_PRT

<400>  789

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  790
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_VH_DNA

<400>  790
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  791
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HCDR1_DNA

<400>  791
cactatggca tgcac                                                        15


<210>  792
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HCDR2_DNA

<400>  792
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  793
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HCDR3_DNA

<400>  793
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  794
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_VL_DNA

<400>  794
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  795
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LCDR1_DNA

<400>  795
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  796
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LCDR2_DNA

<400>  796
accaacaaca gacggcccag c                                                 21


<210>  797
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LCDR3_DNA

<400>  797
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  798
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HC_PRT

<400>  798

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  799
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LC_PRT

<400>  799

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  800
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_HC_DNA

<400>  800
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  801
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-18436_18206-gl17-hIgG1Lambda_LC_DNA

<400>  801
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  802
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_VH_PRT

<400>  802

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  803
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HCDR1_PRT

<400>  803

Ser Tyr Gly Met His 
1               5   


<210>  804
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HCDR2_PRT

<400>  804

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  805
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HCDR3_PRT

<400>  805

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  806
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_VL_PRT

<400>  806

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  807
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LCDR1_PRT

<400>  807

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  808
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LCDR2_PRT

<400>  808

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  809
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LCDR3_PRT

<400>  809

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  810
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_VH_DNA

<400>  810
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  811
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HCDR1_DNA

<400>  811
agctatggca tgcac                                                        15


<210>  812
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HCDR2_DNA

<400>  812
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  813
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HCDR3_DNA

<400>  813
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  814
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_VL_DNA

<400>  814
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  815
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LCDR1_DNA

<400>  815
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  816
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LCDR2_DNA

<400>  816
accaacaaca gacggcccag c                                                 21


<210>  817
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LCDR3_DNA

<400>  817
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  818
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HC_PRT

<400>  818

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  819
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LC_PRT

<400>  819

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  820
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_HC_DNA

<400>  820
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  821
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-19571_18206-gl25-hIgG1Lambda_LC_DNA

<400>  821
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  822
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_HC_DNA

<400>  822
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  823
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-21360_18206-gl25-gl13-hIgG1Lambda_LC_DNA

<400>  823
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  824
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1lambda_HC_DNA

<400>  824
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggcaag                               1356


<210>  825
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-23411_21360-hIgG1lambda_LC_DNA

<400>  825
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  826
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_VH_PRT

<400>  826

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  827
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HCDR1_PRT

<400>  827

Ser Tyr Gly Met His 
1               5   


<210>  828
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HCDR2_PRT

<400>  828

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  829
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HCDR3_PRT

<400>  829

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  830
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_VL_PRT

<400>  830

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  831
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LCDR1_PRT

<400>  831

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  832
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LCDR2_PRT

<400>  832

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  833
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LCDR3_PRT

<400>  833

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  834
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_VH_DNA

<400>  834
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  835
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HCDR1_DNA

<400>  835
agctatggca tgcac                                                        15


<210>  836
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HCDR2_DNA

<400>  836
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  837
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HCDR3_DNA

<400>  837
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  838
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_VL_DNA

<400>  838
cagtctgttc tgacacagcc tccatccgtg tctggcacac ctggccagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggctc taagagcggc accagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  839
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LCDR1_DNA

<400>  839
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  840
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LCDR2_DNA

<400>  840
accaacaaca gacggcccag c                                                 21


<210>  841
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LCDR3_DNA

<400>  841
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  842
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HC_PRT

<400>  842

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  843
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LC_PRT

<400>  843

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  844
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_HC_DNA

<400>  844
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  845
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27477_18206-gl10-gl25-hIgG1Lambda_LC_DNA

<400>  845
cagtctgttc tgacacagcc tccatccgtg tctggcacac ctggccagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggctc taagagcggc accagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  846
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_VH_PRT

<400>  846

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  847
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HCDR1_PRT

<400>  847

Ser Tyr Gly Met His 
1               5   


<210>  848
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HCDR2_PRT

<400>  848

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  849
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HCDR3_PRT

<400>  849

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  850
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_VL_PRT

<400>  850

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  851
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LCDR1_PRT

<400>  851

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  852
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LCDR2_PRT

<400>  852

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  853
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LCDR3_PRT

<400>  853

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  854
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_VH_DNA

<400>  854
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  855
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HCDR1_DNA

<400>  855
agctatggca tgcac                                                        15


<210>  856
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HCDR2_DNA

<400>  856
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  857
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HCDR3_DNA

<400>  857
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  858
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_VL_DNA

<400>  858
cagtctgttc tgacacagcc tccatctgct agcggagccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  859
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LCDR1_DNA

<400>  859
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  860
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LCDR2_DNA

<400>  860
accaacaaca gacggcccag c                                                 21


<210>  861
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LCDR3_DNA

<400>  861
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  862
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HC_PRT

<400>  862

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  863
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LC_PRT

<400>  863

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  864
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_HC_DNA

<400>  864
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  865
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27478_18206-gl11-gl25-hIgG1Lambda_LC_DNA

<400>  865
cagtctgttc tgacacagcc tccatctgct agcggagccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  866
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_VH_PRT

<400>  866

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  867
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HCDR1_PRT

<400>  867

Ser Tyr Gly Met His 
1               5   


<210>  868
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HCDR2_PRT

<400>  868

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  869
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HCDR3_PRT

<400>  869

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  870
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_VL_PRT

<400>  870

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  871
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LCDR1_PRT

<400>  871

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  872
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LCDR2_PRT

<400>  872

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  873
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LCDR3_PRT

<400>  873

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  874
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_VH_DNA

<400>  874
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  875
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HCDR1_DNA

<400>  875
agctatggca tgcac                                                        15


<210>  876
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HCDR2_DNA

<400>  876
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  877
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HCDR3_DNA

<400>  877
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  878
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_VL_DNA

<400>  878
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  879
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LCDR1_DNA

<400>  879
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  880
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LCDR2_DNA

<400>  880
accaacaaca gacggcccag c                                                 21


<210>  881
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LCDR3_DNA

<400>  881
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  882
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HC_PRT

<400>  882

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  883
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LC_PRT

<400>  883

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  884
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_HC_DNA

<400>  884
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  885
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27479_18206-gl13-gl14-hIgG1Lambda_LC_DNA

<400>  885
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  886
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_VH_PRT

<400>  886

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  887
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HCDR1_PRT

<400>  887

His Tyr Gly Met His 
1               5   


<210>  888
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HCDR2_PRT

<400>  888

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  889
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HCDR3_PRT

<400>  889

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  890
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_VL_PRT

<400>  890

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  891
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LCDR1_PRT

<400>  891

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  892
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LCDR2_PRT

<400>  892

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  893
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LCDR3_PRT

<400>  893

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  894
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_VH_DNA

<400>  894
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  895
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HCDR1_DNA

<400>  895
cactatggca tgcac                                                        15


<210>  896
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HCDR2_DNA

<400>  896
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  897
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HCDR3_DNA

<400>  897
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  898
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_VL_DNA

<400>  898
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  899
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LCDR1_DNA

<400>  899
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  900
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LCDR2_DNA

<400>  900
accaacaaca gacggcccag c                                                 21


<210>  901
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LCDR3_DNA

<400>  901
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  902
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HC_PRT

<400>  902

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  903
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LC_PRT

<400>  903

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  904
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_HC_DNA

<400>  904
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggc                                  1353


<210>  905
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-27480_18206-gl13-gl20-hIgG1Lambda_LC_DNA

<400>  905
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  906
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_VH_PRT

<400>  906

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  907
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HCDR1_PRT

<400>  907

His Tyr Gly Met His 
1               5   


<210>  908
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HCDR2_PRT

<400>  908

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  909
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HCDR3_PRT

<400>  909

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  910
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_VL_PRT

<400>  910

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  911
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LCDR1_PRT

<400>  911

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  912
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LCDR2_PRT

<400>  912

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  913
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LCDR3_PRT

<400>  913

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  914
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_VH_DNA

<400>  914
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  915
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HCDR1_DNA

<400>  915
cactatggca tgcac                                                        15


<210>  916
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HCDR2_DNA

<400>  916
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  917
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HCDR3_DNA

<400>  917
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  918
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_VL_DNA

<400>  918
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  919
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LCDR1_DNA

<400>  919
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  920
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LCDR2_DNA

<400>  920
accaacaaca gacggcccag c                                                 21


<210>  921
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LCDR3_DNA

<400>  921
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  922
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HC_PRT

<400>  922

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  923
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LC_PRT

<400>  923

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  924
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_HC_DNA

<400>  924
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggcaag                               1356


<210>  925
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29367_18206-hIgG1wtLambda_LC_DNA

<400>  925
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  926
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_VH_PRT

<400>  926

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  927
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HCDR1_PRT

<400>  927

His Tyr Gly Met His 
1               5   


<210>  928
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HCDR2_PRT

<400>  928

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  929
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HCDR3_PRT

<400>  929

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  930
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_VL_PRT

<400>  930

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  931
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LCDR1_PRT

<400>  931

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  932
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LCDR2_PRT

<400>  932

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  933
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LCDR3_PRT

<400>  933

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  934
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_VH_DNA

<400>  934
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  935
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HCDR1_DNA

<400>  935
cactatggca tgcac                                                        15


<210>  936
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HCDR2_DNA

<400>  936
ggcatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  937
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HCDR3_DNA

<400>  937
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  938
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_VL_DNA

<400>  938
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  939
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LCDR1_DNA

<400>  939
acaggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  940
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LCDR2_DNA

<400>  940
accaacaaca gacggcccag c                                                 21


<210>  941
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LCDR3_DNA

<400>  941
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  942
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HC_PRT

<400>  942

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  943
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LC_PRT

<400>  943

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  944
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_HC_DNA

<400>  944
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc cactatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccggc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggcaag                               1356


<210>  945
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29368_18432-hIgG1wtLambda_LC_DNA

<400>  945
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  946
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_VH_PRT

<400>  946

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  947
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HCDR1_PRT

<400>  947

Ser Tyr Gly Met His 
1               5   


<210>  948
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HCDR2_PRT

<400>  948

Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  949
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HCDR3_PRT

<400>  949

Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr 
1               5                   10              


<210>  950
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_VL_PRT

<400>  950

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  951
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LCDR1_PRT

<400>  951

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val His 
1               5                   10                  


<210>  952
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LCDR2_PRT

<400>  952

Thr Asn Asn Arg Arg Pro Ser 
1               5           


<210>  953
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LCDR3_PRT

<400>  953

Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  954
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_VH_DNA

<400>  954
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttca                                                                 366


<210>  955
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HCDR1_DNA

<400>  955
agctatggca tgcac                                                        15


<210>  956
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HCDR2_DNA

<400>  956
gccatcaact ggaatggcgg ctctacaggc tacgccgact ctgtgaaggg c                51


<210>  957
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HCDR3_DNA

<400>  957
ggccaccaca gcggctacga cggcagattc tttgactat                              39


<210>  958
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_VL_DNA

<400>  958
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg cta                                   333


<210>  959
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LCDR1_DNA

<400>  959
accggcagca gctccaatat cggagccggc tacaacgtgc ac                          42


<210>  960
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LCDR2_DNA

<400>  960
accaacaaca gacggcccag c                                                 21


<210>  961
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LCDR3_DNA

<400>  961
gccgcctggg atgcttctct gagcggatgg gtt                                    33


<210>  962
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HC_PRT

<400>  962

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His His Ser Gly Tyr Asp Gly Arg Phe Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  963
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LC_PRT

<400>  963

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  964
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_HC_DNA

<400>  964
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcaactgga atggcggctc tacaggctac      180

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggccac      300

cacagcggct acgacggcag attctttgac tattggggcc agggcaccct ggtcacagtt      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggcaag                               1356


<210>  965
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-29369_19571-hIgG1wtlambda_LC_DNA

<400>  965
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctaca acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacaccaaca acagacggcc cagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactattgc gccgcctggg atgcttctct gagcggatgg      300

gttttcggcg gaggcaccaa actgacagtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


