                         SEQUENCE LISTING

<110>  Ferring Ventures SA
       Galibert, Lionel
 
<120>  Improved Adeno-Associated Virus Gene Therapy Vectors

<130>  P130599PC00

<140>  PCT/EP2021/067569
<141>  2021-06-25

<150>  US 63/043,837
<151>  2020-06-25

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV1 MAAP

<400>  1

Asn Leu Glu Pro Arg Ser Pro Lys Pro Thr Ser Lys Ser Arg Thr Thr 
1               5                   10                  15      


Ala Gly Val Trp Cys Phe Leu Ala Thr Ser Thr Ser Asp Pro Ser Thr 
            20                  25                  30          


Asp Ser Thr Arg Gly Ser Pro Ser Thr Arg Arg Thr Gln Arg Pro Ser 
        35                  40                  45              


Ser Thr Thr Pro Arg Thr Thr Ser Ser Ser Lys Arg Val Thr Ile Arg 
    50                  55                  60                  


Thr Cys Gly Ile Thr Thr Pro Thr Pro Ser Phe Arg Ser Val Cys Lys 
65                  70                  75                  80  


Lys Ile Arg Leu Leu Gly Ala Thr Ser Gly Glu Gln Ser Ser Arg Pro 
                85                  90                  95      


Arg Ser Gly Phe Ser Asn Leu Ser Val Trp Leu Arg Lys Ala Leu Arg 
            100                 105                 110         


Arg Leu Leu Glu Arg Asn Val Arg 
        115                 120 


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 MAAP

<400>  2

Leu Ala His His His Gln Ser Pro Gln Ser Gly Ile Arg Thr Thr Ala 
1               5                   10                  15      


Gly Val Leu Cys Phe Leu Gly Thr Ser Thr Ser Asp Pro Ser Thr Asp 
            20                  25                  30          


Ser Thr Arg Glu Ser Arg Ser Thr Arg Gln Thr Pro Arg Pro Ser Ser 
        35                  40                  45              


Thr Thr Lys Pro Thr Thr Gly Ser Ser Thr Ala Glu Thr Thr Arg Thr 
    50                  55                  60                  


Ser Ser Thr Thr Thr Pro Thr Arg Ser Phe Arg Ser Ala Leu Lys Lys 
65                  70                  75                  80  


Ile Arg Leu Leu Gly Ala Thr Ser Asp Glu Gln Ser Ser Arg Arg Lys 
                85                  90                  95      


Arg Gly Phe Leu Asn Leu Trp Ala Trp Leu Arg Asn Leu Leu Arg Arg 
            100                 105                 110         


Leu Arg Glu Lys Arg Gly Arg 
        115                 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV3 MAAP

<400>  3

Asn Leu Glu Ser Leu Asn Pro Lys Arg Thr Asn Asn Thr Arg Thr Thr 
1               5                   10                  15      


Val Gly Val Leu Cys Phe Arg Val Thr Asn Thr Ser Asp Pro Val Thr 
            20                  25                  30          


Asp Ser Thr Lys Glu Ser Arg Ser Thr Arg Arg Thr Arg Gln Pro Ser 
        35                  40                  45              


Asn Thr Thr Lys Leu Thr Thr Ser Ser Ser Arg Pro Val Thr Thr Arg 
    50                  55                  60                  


Thr Ser Ser Thr Thr Thr Pro Thr Pro Ser Phe Arg Ser Val Phe Lys 
65                  70                  75                  80  


Lys Ile Arg Leu Leu Gly Ala Thr Leu Ala Glu Gln Ser Ser Arg Pro 
                85                  90                  95      


Lys Arg Gly Ser Leu Ser Leu Leu Val Trp Leu Arg Lys Gln Leu Lys 
            100                 105                 110         


Arg Leu Leu Glu Arg Arg Gly Leu 
        115                 120 


<210>  4
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV4 MAAP

<400>  4

Arg Thr Thr Ser Leu Lys Ala Phe Glu Ser Gly Gly Arg Cys Asn Leu 
1               5                   10                  15      


Glu Pro Leu Asn Pro Arg Gln Ile Asn Asn Ile Arg Thr Thr Leu Gly 
            20                  25                  30          


Val Leu Cys Phe Arg Val Thr Asn Thr Ser Asp Pro Ala Thr Asp Ser 
        35                  40                  45              


Thr Arg Gly Asn Pro Ser Thr Gln Arg Thr Arg Gln Pro Ser Ser Thr 
    50                  55                  60                  


Thr Arg Pro Thr Thr Ser Ser Ser Arg Pro Val Thr Thr Pro Thr Ser 
65                  70                  75                  80  


Ser Thr Thr Thr Pro Thr Arg Ser Ser Ser Ser Gly Phe Arg Ala Thr 
                85                  90                  95      


His Arg Leu Gly Ala Thr Ser Ala Glu Gln Ser Ser Arg Pro Lys Arg 
            100                 105                 110         


Gly Phe Leu Asn Leu Leu Val Trp Leu Ser Lys Arg Val Arg Arg Leu 
        115                 120                 125             


Leu Glu Arg Arg Asp Arg 
    130                 


<210>  5
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV5 MAAP

<400>  5

Ser Cys Leu Leu Leu Ile Thr Leu Gln Ile Gly Trp Lys Lys Leu Val 
1               5                   10                  15      


Lys Val Phe Ala Ser Phe Trp Ala Leu Lys Arg Ala His Arg Asn Gln 
            20                  25                  30          


Asn Pro Ile Ser Ser Ile Lys Ile Lys Pro Val Val Leu Cys Cys Leu 
        35                  40                  45              


Val Ile Thr Ile Ser Asp Pro Glu Thr Val Ser Ile Glu Glu Ser Leu 
    50                  55                  60                  


Ser Thr Gly Gln Thr Arg Ser Arg Glu Ser Thr Thr Ser Arg Thr Thr 
65                  70                  75                  80  


Ser Ser Leu Arg Arg Glu Thr Thr Pro Thr Ser Ser Thr Thr Thr Arg 
                85                  90                  95      


Thr Pro Ser Phe Arg Arg Ser Ser Pro Thr Thr His Pro Ser Gly Glu 
            100                 105                 110         


Thr Ser Glu Arg Gln Ser Phe Arg Pro Arg Lys Gly Phe Ser Asn Leu 
        115                 120                 125             


Leu Ala Trp Leu Lys Arg Val Leu Arg Arg Pro Leu Pro Glu Ser Gly 
    130                 135                 140                 


<210>  6
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV6 MAAP

<400>  6

Asn Leu Glu Pro Arg Asn Pro Lys Pro Thr Ser Lys Ser Arg Thr Thr 
1               5                   10                  15      


Ala Gly Val Trp Cys Phe Leu Ala Thr Ser Thr Ser Asp Pro Ser Thr 
            20                  25                  30          


Asp Ser Thr Arg Gly Ser Pro Ser Thr Arg Arg Met Gln Arg Pro Ser 
        35                  40                  45              


Ser Thr Thr Arg Pro Thr Thr Ser Ser Ser Lys Arg Val Thr Ile Arg 
    50                  55                  60                  


Thr Cys Gly Ile Thr Thr Pro Thr Pro Ser Phe Ser Thr Ser Asp Pro 
65                  70                  75                  80  


Ser Thr Asp Ser Thr Arg Gly Ser Pro Ser Thr Arg Arg Met Gln Arg 
                85                  90                  95      


Pro Ser Ser Thr Thr Arg Pro Thr Thr Ser Ser Ser Lys Arg Val Thr 
            100                 105                 110         


Ile Arg Thr Cys Gly Ile Thr Thr Pro Thr Pro Ser Phe Arg Ser Val 
        115                 120                 125             


Cys Lys Lys Ile Arg Leu Leu Gly Ala Thr Ser Gly Glu Gln Ser Ser 
    130                 135                 140                 


Arg Pro Arg Arg Gly Phe Ser Asn Leu Leu Val Trp Leu Arg Lys Val 
145                 150                 155                 160 


Leu Arg Arg Leu Leu Glu Arg Asn Val Arg 
                165                 170 


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV7 MAAP

<400>  7

Asn Leu Glu Pro Arg Asn Pro Lys Pro Thr Ser Lys Ser Arg Thr Thr 
1               5                   10                  15      


Ala Gly Val Trp Cys Phe Leu Ala Thr Ser Thr Ser Asp Pro Ser Thr 
            20                  25                  30          


Asp Ser Thr Arg Gly Ser Pro Ser Thr Arg Arg Thr Gln Arg Pro Ser 
        35                  40                  45              


Ser Thr Thr Arg Pro Thr Thr Ser Ser Ser Lys Arg Val Thr Ile Arg 
    50                  55                  60                  


Thr Cys Gly Ile Thr Thr Pro Thr Pro Ser Phe Arg Ser Val Cys Lys 
65                  70                  75                  80  


Lys Ile Arg His Leu Gly Ala Thr Ser Gly Glu Gln Ser Ser Arg Pro 
                85                  90                  95      


Arg Ser Gly Phe Ser Asn Leu Ser Val Trp Leu Arg Lys Ala Leu Arg 
            100                 105                 110         


Arg Leu Leu Gln Arg Arg Asp Arg 
        115                 120 


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV8 MAAP

<400>  8

Asn Leu Glu Pro Arg Ser Pro Lys Pro Thr Ser Lys Ser Arg Thr Thr 
1               5                   10                  15      


Ala Gly Val Trp Cys Phe Leu Ala Thr Ser Thr Ser Asp Pro Ser Thr 
            20                  25                  30          


Asp Ser Thr Arg Gly Ser Pro Ser Thr Arg Arg Thr Gln Arg Pro Ser 
        35                  40                  45              


Ser Thr Thr Arg Pro Thr Thr Ser Ser Cys Arg Arg Val Thr Ile Arg 
    50                  55                  60                  


Thr Cys Gly Ile Thr Thr Pro Thr Pro Ser Phe Arg Ser Val Cys Lys 
65                  70                  75                  80  


Lys Ile Arg Leu Leu Gly Ala Thr Ser Gly Glu Gln Ser Ser Arg Pro 
                85                  90                  95      


Arg Ser Gly Phe Ser Asn Leu Ser Val Trp Leu Arg Lys Ala Leu Arg 
            100                 105                 110         


Arg Leu Leu Glu Arg Arg Asp Arg 
        115                 120 


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 MAAP

<400>  9

Leu Glu Pro Leu Asn Pro Arg Gln Ile Asn Asn Ile Lys Thr Thr Leu 
1               5                   10                  15      


Glu Val Leu Cys Phe Arg Val Thr Asn Thr Leu Asp Pro Ala Thr Asp 
            20                  25                  30          


Ser Thr Arg Gly Ser Arg Ser Thr Gln Gln Thr Arg Arg Pro Ser Ser 
        35                  40                  45              


Thr Thr Arg Pro Thr Thr Ser Ser Ser Arg Pro Glu Thr Thr Arg Thr 
    50                  55                  60                  


Ser Ser Thr Thr Thr Pro Thr Pro Ser Ser Arg Ser Gly Ser Lys Lys 
65                  70                  75                  80  


Ile Arg Leu Leu Gly Ala Thr Ser Gly Glu Gln Ser Ser Arg Pro Lys 
                85                  90                  95      


Arg Gly Phe Leu Asn Leu Leu Val Trp Leu Arg Lys Arg Leu Arg Arg 
            100                 105                 110         


Leu Leu Glu Arg Arg Gly Leu 
        115                 


<210>  10
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV10 MAAP

<400>  10

Asn Leu Glu Pro Pro Ser Pro Arg Pro Thr Ser Arg Ser Arg Thr Thr 
1               5                   10                  15      


Ala Gly Val Trp Cys Phe Leu Ala Thr Ser Thr Ser Asp Pro Ser Thr 
            20                  25                  30          


Asp Ser Thr Arg Gly Ser Pro Ser Thr Arg Arg Thr Gln Arg Pro Ser 
        35                  40                  45              


Ser Thr Thr Arg Pro Thr Thr Ser Ser Ser Lys Arg Val Thr Ile Arg 
    50                  55                  60                  


Thr Cys Gly Ile Thr Thr Pro Thr Pro Ser Phe Arg Ser Val Cys Lys 
65                  70                  75                  80  


Lys Ile Arg Leu Leu Gly Ala Thr Ser Gly Glu Gln Ser Ser Arg Pro 
                85                  90                  95      


Arg Ser Gly Phe Ser Asn Leu Ser Val Trp Leu Arg Lys Leu Leu Arg 
            100                 105                 110         


Arg Leu Leu Glu Arg Arg Asp Arg 
        115                 120 


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV consensus MAAP


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Asn Leu Glu Pro Xaa Asn Pro Xaa Pro Xaa Ser Xaa Ile Arg Thr Thr 
1               5                   10                  15      


Ala Gly Val Leu Cys Phe Leu Xaa Thr Ser Thr Ser Asp Pro Ser Thr 
            20                  25                  30          


Asp Ser Thr Arg Gly Ser Xaa Ser Thr Arg Arg Thr Xaa Arg Pro Ser 
        35                  40                  45              


Ser Thr Thr Arg Pro Thr Thr Ser Ser Ser Arg Arg Val Thr Thr Arg 
    50                  55                  60                  


Thr Ser Ser Thr Thr Thr Pro Thr Pro Ser Phe Arg Ser Xaa Xaa Lys 
65                  70                  75                  80  


Lys Ile Arg Leu Leu Gly Ala Thr Ser Xaa Glu Gln Ser Ser Arg Pro 
                85                  90                  95      


Arg Arg Gly Phe Ser Asn Leu Leu Val Trp Leu Arg Lys Xaa Leu Arg 
            100                 105                 110         


Arg Leu Leu Glu Arg Arg Gly Arg 
        115                 120 


<210>  12
<211>  6952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p0230-pUC-K-AAV2wt-Reverse

<400>  12
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt       60

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt      120

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat      180

aatattgaaa aaggaagagt atgagccata ttcaacggga aacgtcttgc tctaggccgc      240

gattaaattc caacatggat gctgatttat atgggtataa atgggctcgc gataatgtcg      300

ggcaatcagg tgcgacaatc tatcgattgt atgggaagcc cgatgcgcca gagttgtttc      360

tgaaacatgg caaaggtagc gttgccaatg atgttacaga tgagatggtc agactaaact      420

ggctgacgga atttatgcct cttccgacca tcaagcattt tatccgtact cctgatgatg      480

catggttact caccactgcg atccctggga aaacagcatt ccaggtatta gaagaatatc      540

ctgattcagg tgaaaatatt gttgatgcgc tggcagtgtt cctgcgccgg ttgcattcga      600

ttcctgtttg taattgtcct tttaacagcg atcgcgtatt tcgtctcgct caggcgcaat      660

cacgaatgaa taacggtttg gttgatgcga gtgattttga tgacgagcgt aatggctggc      720

ctgttgaaca agtctggaaa gaaatgcata aacttttgcc attctcaccg gattcagtcg      780

tcactcatgg tgatttctca cttgataacc ttatttttga cgaggggaaa ttaataggtt      840

gtattgatgt tggacgagtc ggaatcgcag accgatacca ggatcttgcc atcctatgga      900

actgcctcgg tgagttttct ccttcattac agaaacggct ttttcaaaaa tatggtattg      960

ataatcctga tatgaataaa ttgcagtttc atttgatgct cgatgagttt ttctaactgt     1020

cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa     1080

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     1140

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     1200

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     1260

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     1320

taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     1380

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     1440

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     1500

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     1560

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     1620

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     1680

acgcctggta tctttatagt cctgtcaggt ttcgccacct ctgacttgag cgtcgatttt     1740

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     1800

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt     1860

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga     1920

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc     1980

tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag     2040

cgggcagtga gcgcaacgca atttaattaa tcagatccct caatagcggc cttggccact     2100

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     2160

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc     2220

atcactaggg gttcctggag gggtggagtc gtgacgtgaa ttacgtcata gggttaggga     2280

ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg     2340

ctgggtattt aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac     2400

gcgcagccgc catgccgggg ttttacgaga ttgtgattaa ggtccccagc gaccttgacg     2460

agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag gaatgggagt     2520

tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg accgtggccg     2580

agaagctgca gcacgacttt ctgacggaat ggcgccgtgt gagtaaggcc ccggaggccc     2640

ttttctttgt gcaatttgag aagggagaga gctacttcca catgcacgtg ctcgtggaaa     2700

ccaccggggt gaaatccatg gttttgggac gtttcctgag tcagattcgc gaaaaactga     2760

ttcagagaat ttaccgcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga     2820

ccagaaatgg cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact     2880

tgctccccaa aacccagcct gagctccagt gggcatggac taatatggaa cagtatttaa     2940

gcgcctgttt gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt     3000

cgcagacgca ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca     3060

gatcaaaaac ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta     3120

cctcggagaa gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct     3180

ccaactcgcg gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga     3240

ctaaaaccgc ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc     3300

ggatttataa aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc     3360

tgggatgggc cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa     3420

ctaccgggaa gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg     3480

taaactggac caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt     3540

gggaggaggg gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa     3600

gcaaggtgcg cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga     3660

tcgtcacctc caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac     3720

accagcagcc gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg     3780

actttgggaa ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg     3840

tggttgaggt ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccaccc     3900

ccagtgacgc agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga     3960

cgtcagacgc ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc     4020

acgtgggcat gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt     4080

caaatatctg cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat     4140

ctcaacccgt ttctgtcatc aaaaaggcgt atcagaaact gtgctacatt catcatatca     4200

tgggaaaggt gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact     4260

gcatctttga acaataaatg atttaaatca ggtatggctg ccgatggtta tcttccagat     4320

tggctcgagg acactctctc tgaaggaata agacagtggt ggaagctcaa acctggccca     4380

ccaccaccaa agcccgcaga gcggcataag gacgacagca ggggtcttgt gcttcctggg     4440

tacaagtacc tcggaccctt caacggactc gacaagggag agccggtcaa cgaggcagac     4500

gccgcggccc tcgagcacga caaagcctac gaccggcagc tcgacagcgg agacaacccg     4560

tacctcaagt acaaccacgc cgacgcggag tttcaggagc accttaaaga agatacatct     4620

tttgggggca acctcagacg agcagtcttc caggcgaaaa agagggttct tgaacctctg     4680

ggcctggttg aggaacctgt taagacggct ccgggaaaaa agaggccggt agagcactct     4740

cctgtggagc cagactcctc ctcgggaacc ggaaaggcgg gccagcagcc tgcaagaaaa     4800

agattgaatt ttggtcagac tggagacgca gactcagtac ctgaccccca gcctctcgga     4860

cagccaccag cagccccctc tggtctggga actaatacga tggctacagg cagtggcaca     4920

ccaatggcag acaataacga gggcgccgac ggagtgggta attcctcggg aaattggcat     4980

tgcgattcca catggatggg cgacagagtc atcaccacca gcacccgaac ctgggccctg     5040

cccacctaca acaaccacct ctacaaacaa atttccagcc aatcaggagc ctcgaacgac     5100

aatcactact ttggctacag caccccttgg gggtattttg acttcaacag attccactgc     5160

cacttttcac cacgtgactg gcaaagactc atcaacaaca actggggatt ccgacccaag     5220

agactcaact tcaagctctt taacattcaa gtcaaagagg tcacgcagaa tgacggtacg     5280

acgacgattg ccaataacct taccagcacg gttcaggtgt ttactgactc ggagtaccag     5340

ctcccgtacg tcctcggctc ggcgcatcaa ggatgcctcc cgccgttccc agcagacgtc     5400

ttcatggtgc cacagtatgg atacctcacc ctgaacaacg ggagtcaggc agtaggacgc     5460

tcttcatttt actgcctgga gtactttcct tctcagatgc tgcgtaccgg aaacaacttt     5520

accttcagct acacttttga ggacgttcct ttccacagca gctacgctca cagccagagt     5580

ctggaccgtc tcatgaatcc tctcatcgac cagtacctgt attacttgag cagaacaaac     5640

actccaagtg gaaccaccac gcagtcaagg cttcagtttt ctcaggccgg agcgagtgac     5700

attcgggacc agtctaggaa ctggcttcct ggaccctgtt accgccagca gcgagtatca     5760

aagacatctg cggataacaa caacagtgaa tactcgtgga ctggagctac caagtaccac     5820

ctcaatggca gagactctct ggtgaatccg ggcccggcca tggcaagcca caaggacgat     5880

gaagaaaagt tttttcctca gagcggggtt ctcatctttg ggaagcaagg ctcagagaaa     5940

acaaatgtgg acattgaaaa ggtcatgatt acagacgaag aggaaatcag gacaaccaat     6000

cccgtggcta cggagcagta tggttctgta tctaccaacc tccagagagg caacagacaa     6060

gcagctaccg cagatgtcaa cacacaaggc gttcttccag gcatggtctg gcaggacaga     6120

gatgtgtacc ttcaggggcc catctgggca aagattccac acacggacgg acattttcac     6180

ccctctcccc tcatgggtgg attcggactt aaacaccctc ctccacagat tctcatcaag     6240

aacaccccgg tacctgcgaa tccttcgacc accttcagtg cggcaaagtt tgcttccttc     6300

atcacacagt actccacggg acaggtcagc gtggagatcg agtgggagct gcagaaggaa     6360

aacagcaaac gctggaatcc cgaaattcag tacacttcca actacaacaa gtctgttaat     6420

gtggacttta ctgtggacac taatggcgtg tattcagagc ctcgccccat tggcaccaga     6480

tacctgactc gtaatctgta attgcttgtt aatcaataaa ccgtttaatt cgtttcagtt     6540

gaactttggt ctctgcgtat ttctttctta tctagtttcc atggctacgt agataagtag     6600

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     6660

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     6720

gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa gccactcgag     6780

cacctaggag gcgcgccacg gccgtagtta agccagcccc gacacccgcc aacacccgct     6840

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     6900

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc ga             6952


<210>  13
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 MAAP gene

<400>  13
ctggcccacc accaccaaag cccgcagagc ggcataagga cgacagcagg ggtcttgtgc       60

ttcctgggta caagtacctc ggacccttca acggactcga caagggagag ccggtcaacg      120

aggcagacgc cgcggccctc gagcacgaca aagcctacga ccggcagctc gacagcggag      180

acaacccgta cctcaagtac aaccacgccg acgcggagtt tcaggagcgc cttaaagaag      240

atacgtcttt tgggggcaac ctcggacgag cagtcttcca ggcgaaaaag agggttcttg      300

aacctctggg cctggttgag gaacctgtta agacggctcc gggaaaaaag aggccggtag      360


<210>  14
<211>  6952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p0189-AAV2WT-DS 540-546-554 -> stops

<400>  14
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt       60

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt      120

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat      180

aatattgaaa aaggaagagt atgagccata ttcaacggga aacgtcttgc tctaggccgc      240

gattaaattc caacatggat gctgatttat atgggtataa atgggctcgc gataatgtcg      300

ggcaatcagg tgcgacaatc tatcgattgt atgggaagcc cgatgcgcca gagttgtttc      360

tgaaacatgg caaaggtagc gttgccaatg atgttacaga tgagatggtc agactaaact      420

ggctgacgga atttatgcct cttccgacca tcaagcattt tatccgtact cctgatgatg      480

catggttact caccactgcg atccctggga aaacagcatt ccaggtatta gaagaatatc      540

ctgattcagg tgaaaatatt gttgatgcgc tggcagtgtt cctgcgccgg ttgcattcga      600

ttcctgtttg taattgtcct tttaacagcg atcgcgtatt tcgtctcgct caggcgcaat      660

cacgaatgaa taacggtttg gttgatgcga gtgattttga tgacgagcgt aatggctggc      720

ctgttgaaca agtctggaaa gaaatgcata aacttttgcc attctcaccg gattcagtcg      780

tcactcatgg tgatttctca cttgataacc ttatttttga cgaggggaaa ttaataggtt      840

gtattgatgt tggacgagtc ggaatcgcag accgatacca ggatcttgcc atcctatgga      900

actgcctcgg tgagttttct ccttcattac agaaacggct ttttcaaaaa tatggtattg      960

ataatcctga tatgaataaa ttgcagtttc atttgatgct cgatgagttt ttctaactgt     1020

cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa     1080

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     1140

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     1200

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     1260

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     1320

taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     1380

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     1440

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     1500

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     1560

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     1620

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     1680

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     1740

tgtgatgctc gtcagggggg cagagcctat ggaaaaacgc cagcaacgcg gcctttttac     1800

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt     1860

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga     1920

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc     1980

tccccgcacg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag     2040

cgggcagtga gcgcaacgca atttaattaa tcagatccct caatagcggc cttggccact     2100

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     2160

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc     2220

atcactaggg gttcctggag gggtggagtc gtgacgtgaa ttacgtcata gggttaggga     2280

ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg     2340

ctgggtattt aagcccaagt gagcacacag ggtctccatt ttgaagcggg aggtttgaac     2400

gcgcagccgc catgccgggg ttttacgaga ttgtgattaa ggtccccagc gaccttgacg     2460

agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag gaatgggagt     2520

tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg accgtggccg     2580

agaagctgca gcgcgacttt ctgacggaat ggcgccgtgt gagtaaggcc ccggaggccc     2640

ttttctttgt gcaatttgag aagggagaga gctacttcca catgcacgtg ctcgtggaaa     2700

ccaccggggt gaaatccatg gttttgggac gtttcctgag tcagattcgc gaaaaactga     2760

ttcagagaat ttaccgcggg atcgagccga ctttgccaaa ctggttcacg gtcacaaaga     2820

ccagaaatgg cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact     2880

tgctccccaa aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa     2940

gcgcctgttt gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt     3000

cgcagacgca ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca     3060

gatcaaaaac ttcagccagg tacatggagc tggtcgggtg gctcatggac aaggggatta     3120

cctcggagaa gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct     3180

ccaactcgcg gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga     3240

ctaaaaccgc ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc     3300

ggatttataa aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc     3360

tgggatgggc cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa     3420

ctaccgggaa gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg     3480

taaactggac caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt     3540

gggaggaggg gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa     3600

gcaaggtgcg cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga     3660

tcgtcacctc caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac     3720

accagcagcc gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg     3780

actttgggaa ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg     3840

tggttgaggt ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc     3900

ccagtgacgc agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga     3960

cgtcagacgc ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc     4020

acgtgggcat gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt     4080

caaatatctg cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat     4140

ctcaacccgt ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca     4200

tgggaaaggt gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact     4260

gcatctttga acaataaatg atttaaatca ggtatggctg ccgatggtta tcttccagat     4320

tggctcgagg acactctctc tgaaggaata agacagtggt ggaagctcaa acctggccca     4380

ccaccaccaa agcccgcaga gcggcataag gacgacagca ggggtcttgt gcttcctggg     4440

tacaagtacc tcggaccctt caacggacta gacaagggag agccggtgaa cgaggcagac     4500

gccgcggccc tagagcacga caaagcctac gaccggcagc tcgacagcgg agacaacccg     4560

tacctcaagt acaaccacgc cgacgcggag tttcaggagc gccttaaaga agatacgtct     4620

tttgggggca acctcggacg agcagtcttc caggcgaaaa agagggttct tgaacctctg     4680

ggcctggttg aggaacctgt taagacggct ccgggaaaaa agaggccggt agagcactct     4740

cctgtggagc cagactcctc ctcgggaacc ggaaaggcgg gccagcagcc tgcaagaaaa     4800

agattgaatt ttggtcagac tggagacgca gactcagtac ctgaccccca gcctctcgga     4860

cagccaccag cagccccctc tggtctggga actaatacga tggctacagg cagtggcgca     4920

ccaatggcag acaataacga gggcgccgac ggagtgggta attcctcggg aaattggcat     4980

tgcgattcca catggatggg cgacagagtc atcaccacca gcacccgaac ctgggccctg     5040

cccacctaca acaaccacct ctacaaacaa atttccagcc aatcaggagc ctcgaacgac     5100

aatcactact ttggctacag caccccttgg gggtattttg acttcaacag attccactgc     5160

cacttttcac cacgtgactg gcaaagactc atcaacaaca actggggatt ccgacccaag     5220

agactcaact tcaagctctt taacattcaa gtcaaagagg tcacgcagaa tgacggtacg     5280

acgacgattg ccaataacct taccagcacg gttcaggtgt ttactgactc ggagtaccag     5340

ctcccgtacg tcctcggctc ggcgcatcaa ggatgcctcc cgccgttccc agcagacgtc     5400

ttcatggtgc cacagtatgg atacctcacc ctgaacaacg ggagtcaggc agtaggacgc     5460

tcttcatttt actgcctgga gtactttcct tctcagatgc tgcgtaccgg aaacaacttt     5520

accttcagct acacttttga ggacgttcct ttccacagca gctacgctca cagccagagt     5580

ctggaccgtc tcatgaatcc tctcatcgac cagtacctgt attacttgag cagaacaaac     5640

actccaagtg gaaccaccac gcagtcaagg cttcagtttt ctcaggccgg agcgagtgac     5700

attcgggacc agtctaggaa ctggcttcct ggaccctgtt accgccagca gcgagtatca     5760

aagacatctg cggataacaa caacagtgaa tactcgtgga ctggagctac caagtaccac     5820

ctcaatggca gagactctct ggtgaatccg ggcccggcca tggcaagcca caaggacgat     5880

gaagaaaagt tttttcctca gagcggggtt ctcatctttg ggaagcaagg ctcagagaaa     5940

acaaatgtgg acattgaaaa ggtcatgatt acagacgaag aggaaatcag gacaaccaat     6000

cccgtggcta cggagcagta tggttctgta tctaccaacc tccagagagg caacagacaa     6060

gcagctaccg cagatgtcaa cacacaaggc gttcttccag gcatggtctg gcaggacaga     6120

gatgtgtacc ttcaggggcc catctgggca aagattccac acacggacgg acattttcac     6180

ccctctcccc tcatgggtgg attcggactt aaacaccctc ctccacagat tctcatcaag     6240

aacaccccgg tacctgcgaa tccttcgacc accttcagtg cggcaaagtt tgcttccttc     6300

atcacacagt actccacggg acaggtcagc gtggagatcg agtgggagct gcagaaggaa     6360

aacagcaaac gctggaatcc cgaaattcag tacacttcca actacaacaa gtctgttaat     6420

gtggacttta ctgtggacac taatggcgtg tattcagagc ctcgccccat tggcaccaga     6480

tacctgactc gtaatctgta attgcttgtt aatcaataaa ccgtttaatt cgtttcagtt     6540

gaactttggt ctctgcgtat ttctttctta tctagtttcc atggctacgt agataagtag     6600

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     6660

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     6720

gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa gccactcgag     6780

cacctaggag gcgcgccacg gccgtagtta agccagcccc gacacccgcc aacacccgct     6840

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     6900

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc ga             6952


<210>  15
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p0189-AAV2WT-DS VP1 protein

<400>  15

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  16
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p0189-AAV2WT MAAP #1

<400>  16

Leu Ala His His His Gln Ser Pro Gln Ser Gly Ile Arg Thr Thr Ala 
1               5                   10                  15      


Gly Val Leu Cys Phe Leu Gly Thr Ser Thr Ser Asp Pro Ser Thr Asp 
            20                  25                  30          


<210>  17
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p0189-AAV2WT MAAP #2

<400>  17

Leu Ala His His His Gln Ser Pro Gln Ser Gly Ile Arg Thr Thr Ala 
1               5                   10                  15      


Gly Val Leu Cys Phe Leu Gly Thr Ser Thr Ser Asp Pro Ser Thr Asp 
            20                  25                  30          


Thr Arg Glu Ser Arg 
        35          


<210>  18
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p0189-AAV2WT MAAP #3

<400>  18

Leu Ala His His His Gln Ser Pro Gln Ser Gly Ile Arg Thr Thr Ala 
1               5                   10                  15      


Gly Val Leu Cys Phe Leu Gly Thr Ser Thr Ser Asp Pro Ser Thr Asp 
            20                  25                  30          


Thr Arg Glu Ser Arg Thr Arg Gln Thr Pro Arg Pro 
        35                  40                  


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rep2-PRB


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  ZEN

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  56-FAM is before residue 1.

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  3IABkFQ is after residue 2.

<400>  19
cccgtgtcag aatctcaacc cgtt                                              24


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rep2-FWD

<400>  20
cttcactcac ggacagaaag a                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rep2-Rev

<400>  21
ctggcacctt tcccatgata                                                   20


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad5-E4-PRB


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  56-FAM is before residue 1.

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  ZEN

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  3IABkFQ is after residue 2.

<400>  22
acccagccaa cctacacatt cgtt                                              24


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad5-E4-FWD

<400>  23
catccaccac cgcagaataa                                                   20


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad5-E4-REV

<400>  24
acatggttct tccagctctt c                                                 21


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kan-PRB


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  56-FAM is before residue 1.

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  ZEN

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  3IABkFQ is after residue 2.

<400>  25
tcgcacctga ttgcccgaca ttat                                              24


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kan-FWD

<400>  26
atcgggcttc ccatacaatc                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kan-REV

<400>  27
gctctaggcc gcgattaaa                                                    19


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-MAAP antigen

<400>  28

Lys Lys Ile Arg Leu Leu Gly Ala Thr Ser Asp Glu Gln Ser Ser Arg 
1               5                   10                  15      


Arg Lys Arg Gly 
            20  


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-MAAP antigen

<400>  29

Arg Ser Thr Ser Ser Arg Thr Ser Ser Ala Arg Arg Ile Lys Asp Ala 
1               5                   10                  15      


Ser Arg Arg 
            


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic-amino-acid-rich (BR) cluster

<400>  30

Lys Lys Ile Arg 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic-amino-acid-rich (BR) cluster

<400>  31

Arg Arg Lys Arg 
1               


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic-amino-acid-rich (BR) cluster

<400>  32

Arg Asn Leu Leu Arg Arg Leu Arg Glu Lys Arg Gly Arg 
1               5                   10              


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer CMV-Fwd

<400>  33
catgacctta tgggactttc ct                                                22


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer CMV-Rev

<400>  34
ctatccacgc ccattgatgt a                                                 21


<210>  35
<211>  2211
<212>  DNA
<213>  adeno-associated virus serotype 1

<400>  35
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  36
<211>  2208
<212>  DNA
<213>  adeno-associated virus serotype 2

<400>  36
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  37
<211>  2211
<212>  DNA
<213>  adeno-associated virus serotype 3

<400>  37
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaagg gggctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg agactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

agaggggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgactg gaactgtcaa tcatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccctat tggaacccgg tatctcacac gaaacttgtg a              2211


<210>  38
<211>  2205
<212>  DNA
<213>  adeno-associated virus serotype 4

<400>  38
atgactgacg gttaccttcc agattggcta gaggacaacc tctctgaagg cgttcgagag       60

tggtgggcgc tgcaacctgg agcccctaaa cccaaggcaa atcaacaaca tcaggacaac      120

gctcggggtc ttgtgcttcc gggttacaaa tacctcggac ccggcaacgg actcgacaag      180

ggggaacccg tcaacgcagc ggacgcggca gccctcgagc acgacaaggc ctacgaccag      240

cagctcaagg ccggtgacaa cccctacctc aagtacaacc acgccgacgc ggagttccag      300

cagcggcttc agggcgacac atcgtttggg ggcaacctcg gcagagcagt cttccaggcc      360

aaaaagaggg ttcttgaacc tcttggtctg gttgagcaag cgggtgagac ggctcctgga      420

aagaagagac cgttgattga atccccccag cagcccgact cctccacggg tatcggcaaa      480

aaaggcaagc agccggctaa aaagaagctc gttttcgaag acgaaactgg agcaggcgac      540

ggaccccctg agggatcaac ttccggagcc atgtctgatg acagtgagat gcgtgcagca      600

gctggcggag ctgcagtcga gggcggacaa ggtgccgatg gagtgggtaa tgcctcgggt      660

gattggcatt gcgattccac ctggtctgag ggccacgtca cgaccaccag caccagaacc      720

tgggtcttgc ccacctacaa caaccacctc tacaagcgac tcggagagag cctgcagtcc      780

aacacctaca acggattctc caccccctgg ggatactttg acttcaaccg cttccactgc      840

cacttctcac cacgtgactg gcagcgactc atcaacaaca actggggcat gcgacccaaa      900

gccatgcggg tcaaaatctt caacatccag gtcaaggagg tcacgacgtc gaacggcgag      960

acaacggtgg ctaataacct taccagcacg gttcagatct ttgcggactc gtcgtacgaa     1020

ctgccgtacg tgatggatgc gggtcaagag ggcagcctgc ctccttttcc caacgacgtc     1080

tttatggtgc cccagtacgg ctactgtgga ctggtgaccg gcaacacttc gcagcaacag     1140

actgacagaa atgccttcta ctgcctggag tactttcctt cgcagatgct gcggactggc     1200

aacaactttg aaattacgta cagttttgag aaggtgcctt tccactcgat gtacgcgcac     1260

agccagagcc tggaccggct gatgaaccct ctcatcgacc agtacctgtg gggactgcaa     1320

tcgaccacca ccggaaccac cctgaatgcc gggactgcca ccaccaactt taccaagctg     1380

cggcctacca acttttccaa ctttaaaaag aactggctgc ccgggccttc aatcaagcag     1440

cagggcttct caaagactgc caatcaaaac tacaagatcc ctgccaccgg gtcagacagt     1500

ctcatcaaat acgagacgca cagcactctg gacggaagat ggagtgccct gacccccgga     1560

cctccaatgg ccacggctgg acctgcggac agcaagttca gcaacagcca gctcatcttt     1620

gcggggccta aacagaacgg caacacggcc accgtacccg ggactctgat cttcacctct     1680

gaggaggagc tggcagccac caacgccacc gatacggaca tgtggggcaa cctacctggc     1740

ggtgaccaga gcaacagcaa cctgccgacc gtggacagac tgacagcctt gggagccgtg     1800

cctggaatgg tctggcaaaa cagagacatt tactaccagg gtcccatttg ggccaagatt     1860

cctcataccg atggacactt tcacccctca ccgctgattg gtgggtttgg gctgaaacac     1920

ccgcctcctc aaatttttat caagaacacc ccggtacctg cgaatcctgc aacgaccttc     1980

agctctactc cggtaaactc cttcattact cagtacagca ctggccaggt gtcggtgcag     2040

attgactggg agatccagaa ggagcggtcc aaacgctgga accccgaggt ccagtttacc     2100

tccaactacg gacagcaaaa ctctctgttg tgggctcccg atgcggctgg gaaatacact     2160

gagcctaggg ctatcggtac ccgctacctc acccaccacc tgtaa                     2205


<210>  39
<211>  2175
<212>  DNA
<213>  adeno-associated virus serotype 5

<400>  39
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tttaa                                                      2175


<210>  40
<211>  2211
<212>  DNA
<213>  adeno-associated virus serotype 6

<400>  40
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  41
<211>  2214
<212>  DNA
<213>  adeno-associated virus serotype 7

<400>  41
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtcattt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

gcaaagaaga gaccggtaga gccgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacag tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

attaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccagtg aaactgcagg tagtaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctgc ggttcaagct cttcaacatc      960

caggtcaagg aggtcacgac gaatgacggc gttacgacca tcgctaataa ccttaccagc     1020

acgattcagg tattctcgga ctcggaatac cagctgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca atggcagtca gtctgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac tttgagttca gctacagctt cgaggacgtg     1260

cctttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcccctcatc     1320

gaccagtact tgtactacct ggccagaaca cagagtaacc caggaggcac agctggcaat     1380

cgggaactgc agttttacca gggcgggcct tcaactatgg ccgaacaagc caagaattgg     1440

ttacctggac cttgcttccg gcaacaaaga gtctccaaaa cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     1560

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     1740

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga tggcaacttt cacccgtctc ctttgatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctgatc aagaacactc ccgttcccgc taatcctccg     1980

gaggtgttta ctcctgccaa gtttgcttcg ttcatcacac agtacagcac cggacaagtc     2040

agcgtggaaa tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatt     2100

cagtacacct ccaactttga aaagcagact ggtgtggact ttgccgttga cagccagggt     2160

gtttactctg agcctcgccc tattggcact cgttacctca cccgtaatct gtaa           2214


<210>  42
<211>  2217
<212>  DNA
<213>  adeno-associated virus serotype 8

<400>  42
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210>  43
<211>  2211
<212>  DNA
<213>  adeno-associated virus serotype 9

<400>  43
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  44
<211>  2217
<212>  DNA
<213>  adeno-associated virus serotype 10

<400>  44
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttgggcagac tggcgagtca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gatgtcttca tgattcccca gtacggctac     1140

ctgacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

attgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc caagaactgg     1440

ctgcctggac cttgctaccg gcagcagcga gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctctggtg     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagc     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacaa gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggc     1740

gtggtggctg acaacttgca gcaagccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcacccgt ctcctctgat gggcggcttt     1920

ggacttaaac acccgcctcc acagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatca cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttatc tgacacgtaa tctgtaa        2217


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rep2-PRB


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  ZEN

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  3IABkFQ

<400>  45
cccgtgtcag aatctcaacc cgtt                                              24


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad5-E4-PRB


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  ZEN

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  3IABkFQ

<400>  46
acccagccaa cctacacatt cgtt                                              24


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kan-PRB


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  ZEN

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  3IABkFQ

<400>  47
tcgcacctga ttgcccgaca ttat                                              24


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV-PRB


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  6-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  ZEN

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  IABkFQ

<400>  48
tcgcacctga ttgcccgaca ttat                                              24


