                         SEQUENCE LISTING

<110>  Saiba AG
 
<120>  VIRUS-LIKE PARTICLES OF CMV MODIFIED BY FUSION

<130>  P6015PC00

<150>  EP20182265.7
<151>  2020-06-25

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  218
<212>  PRT
<213>  cucumber mosaic virus

<400>  1

Met Asp Lys Ser Glu Ser Thr Ser Ala Gly Arg Ser Arg Arg Arg Arg 
1               5                   10                  15      


Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala Asp Ala Asn Phe 
            20                  25                  30          


Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys Thr Leu Ala Ala 
        35                  40                  45              


Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly Ser Glu Arg Cys 
    50                  55                  60                  


Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys Pro Pro Lys Ile 
65                  70                  75                  80  


Asp Arg Gly Ser Tyr Tyr Gly Lys Arg Leu Leu Leu Pro Asp Ser Val 
                85                  90                  95      


Thr Glu Tyr Asp Lys Lys Leu Val Ser Arg Ile Gln Ile Arg Val Asn 
            100                 105                 110         


Pro Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr Val Arg Lys Val 
        115                 120                 125             


Pro Ala Ser Ser Asp Leu Ser Val Ala Ala Ile Ser Ala Met Phe Ala 
    130                 135                 140                 


Asp Gly Ala Ser Pro Val Leu Val Tyr Gln Tyr Ala Ala Ser Gly Val 
145                 150                 155                 160 


Gln Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Ala Met Arg Ala Asp 
                165                 170                 175     


Ile Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr Ser Lys Asp Asp 
            180                 185                 190         


Ala Leu Glu Thr Asp Glu Leu Val Leu His Val Asp Val Glu His Gln 
        195                 200                 205             


Arg Ile Pro Thr Ser Gly Val Leu Pro Val 
    210                 215             


<210>  2
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  aa 2-27 of SEQ ID NO:1

<400>  2

Asp Lys Ser Glu Ser Thr Ser Ala Gly Arg Ser Arg Arg Arg Arg Pro 
1               5                   10                  15      


Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25          


<210>  3
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  tetanus toxoid epitope tt830

<400>  3

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  


<210>  4
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  PADRE

<400>  4

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  5
<211>  222
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMVNtt830

<400>  5

Met Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Arg Arg Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25                  30          


Asp Ala Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys 
        35                  40                  45              


Thr Leu Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly 
    50                  55                  60                  


Ser Glu Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys 
65                  70                  75                  80  


Pro Pro Lys Ile Asp Arg Gly Ser Tyr Tyr Gly Lys Arg Leu Leu Leu 
                85                  90                  95      


Pro Asp Ser Val Thr Glu Tyr Asp Lys Lys Leu Val Ser Arg Ile Gln 
            100                 105                 110         


Ile Arg Val Asn Pro Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr 
        115                 120                 125             


Val Arg Lys Val Pro Ala Ser Ser Asp Leu Ser Val Ala Ala Ile Ser 
    130                 135                 140                 


Ala Met Phe Ala Asp Gly Ala Ser Pro Val Leu Val Tyr Gln Tyr Ala 
145                 150                 155                 160 


Ala Ser Gly Val Gln Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Ala 
                165                 170                 175     


Met Arg Ala Asp Ile Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr 
            180                 185                 190         


Ser Lys Asp Asp Ala Leu Glu Thr Asp Glu Leu Val Leu His Val Asp 
        195                 200                 205             


Val Glu His Gln Arg Ile Pro Thr Ser Gly Val Leu Pro Val 
    210                 215                 220         


<210>  6
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA 307-319

<400>  6

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  7
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  HBVnc 50-69

<400>  7

Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu 
1               5                   10                  15      


Met Thr Leu Ala 
            20  


<210>  8
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  CS 378-398

<400>  8

Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val Val Asn Ser 
            20      


<210>  9
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  MT 17-31

<400>  9

Tyr Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val 
1               5                   10                  15      


<210>  10
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  GGGS-linker

<400>  10

Gly Gly Gly Ser 
1               


<210>  11
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  GGGSGS-linker

<400>  11

Gly Gly Gly Ser Gly Ser 
1               5       


<210>  12
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  TT 947-967

<400>  12

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  13
<211>  220
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMV-Npadr

<400>  13

Met Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Arg Arg 
1               5                   10                  15      


Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala Asp Ala 
            20                  25                  30          


Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys Thr Leu 
        35                  40                  45              


Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly Ser Glu 
    50                  55                  60                  


Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys Pro Pro 
65                  70                  75                  80  


Lys Ile Asp Arg Gly Ser Tyr Tyr Gly Lys Arg Leu Leu Leu Pro Asp 
                85                  90                  95      


Ser Val Thr Glu Tyr Asp Lys Lys Leu Val Ser Arg Ile Gln Ile Arg 
            100                 105                 110         


Val Asn Pro Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr Val Arg 
        115                 120                 125             


Lys Val Pro Ala Ser Ser Asp Leu Ser Val Ala Ala Ile Ser Ala Met 
    130                 135                 140                 


Phe Ala Asp Gly Ala Ser Pro Val Leu Val Tyr Gln Tyr Ala Ala Ser 
145                 150                 155                 160 


Gly Val Gln Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Ala Met Arg 
                165                 170                 175     


Ala Asp Ile Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr Ser Lys 
            180                 185                 190         


Asp Asp Ala Leu Glu Thr Asp Glu Leu Val Leu His Val Asp Val Glu 
        195                 200                 205             


His Gln Arg Ile Pro Thr Ser Gly Val Leu Pro Val 
    210                 215                 220 


<210>  14
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  15aa GS-linker

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  10aa GS-linker

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  16
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  12aa GS-linker

<400>  16

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  17
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  20aa GSED-linker

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Asp Glu Asp 
1               5                   10                  15      


Gly Ser 
        


<210>  18
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  15aa GSED-linker

<400>  18

Thr Ser Asp Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward - CM-830NdeF

<400>  19
acacatatgg gccagtatat taaggccaac tcca                                   34


<210>  20
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse - CM-cpR

<400>  20
caaagcttat caaactggga gcaccccaga tgtggga                                37


<210>  21
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward - 830-NcoF

<400>  21
ataccatggg ccagtatatt aaggcca                                           27


<210>  22
<211>  80
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse Cmded-BamR

<400>  22
ggatccatcc tcgtcacctc ctccagatcc acctccacca ctaccacctc ctccagatcc       60

acggtctatt tttggtggct                                                   80


<210>  23
<211>  81
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward CMded-BamF

<400>  23
ggatcccaga ctagtgacga ggatggagga ggtggaagcg gaggaggtgg atcttattat       60

ggtaaaaggt tgttattacc t                                                 81


<210>  24
<211>  211
<212>  PRT
<213>  artificial sequence

<220>
<223>  RBD SARS-CoV2

<400>  24

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
        195                 200                 205             


Val Asn Phe 
    210     


<210>  25
<211>  466
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-nCoV-D

<400>  25

Met Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Arg Arg Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25                  30          


Asp Ala Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys 
        35                  40                  45              


Thr Leu Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly 
    50                  55                  60                  


Ser Glu Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys 
65                  70                  75                  80  


Pro Pro Lys Ile Asp Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Asp Glu Asp Gly Ser Asn Ile Thr Asn Leu Cys 
            100                 105                 110         


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
        115                 120                 125             


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
    130                 135                 140                 


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
145                 150                 155                 160 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
                165                 170                 175     


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
            180                 185                 190         


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
        195                 200                 205             


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
    210                 215                 220                 


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
225                 230                 235                 240 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
                245                 250                 255     


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
            260                 265                 270         


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
        275                 280                 285             


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
    290                 295                 300                 


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Thr Ser Asp 
305                 310                 315                 320 


Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Tyr Gly Lys 
                325                 330                 335     


Arg Leu Leu Leu Pro Asp Ser Val Thr Glu Tyr Asp Lys Lys Leu Val 
            340                 345                 350         


Ser Arg Ile Gln Ile Arg Val Asn Pro Leu Pro Lys Phe Asp Ser Thr 
        355                 360                 365             


Val Trp Val Thr Val Arg Lys Val Pro Ala Ser Ser Asp Leu Ser Val 
    370                 375                 380                 


Ala Ala Ile Ser Ala Met Phe Ala Asp Gly Ala Ser Pro Val Leu Val 
385                 390                 395                 400 


Tyr Gln Tyr Ala Ala Ser Gly Val Gln Ala Asn Asn Lys Leu Leu Tyr 
                405                 410                 415     


Asp Leu Ser Ala Met Arg Ala Asp Ile Gly Asp Met Arg Lys Tyr Ala 
            420                 425                 430         


Val Leu Val Tyr Ser Lys Asp Asp Ala Leu Glu Thr Asp Glu Leu Val 
        435                 440                 445             


Leu His Val Asp Val Glu His Gln Arg Ile Pro Thr Ser Gly Val Leu 
    450                 455                 460                 


Pro Val 
465     


<210>  26
<211>  1410
<212>  DNA
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-nCoV-D

<400>  26
ccatgggcca gtatattaag gccaactcca aatttatcgg gattaccgag cgtcgacgtc       60

gtccgcgtcg tggttcccgc tccgccccct cctccgcgga tgctaacttt agagtcttgt      120

cgcagcagct ttcgcgactt aataagacgt tagcagctgg tcgtccaact attaaccacc      180

caacctttgt agggagtgaa cgctgtaaac ctgggtacac gttcacatct atcaccctaa      240

agccaccaaa aatagaccgt ggatctggag gaggtggtag tggtggaggt ggatctggag      300

gaggtgacga ggatggatcc aacattacca acctgtgccc gtttggcgaa gtgtttaacg      360

cgacccgctt tgcgagcgtg tatgcgtgga accgcaaacg cattagcaac tgcgtggcgg      420

attatagcgt gctgtataac agcgcgagct ttagcacctt taaatgctat ggcgtgagcc      480

cgaccaaact gaacgatctg tgctttacca acgtgtatgc ggatagcttt gtgattcgcg      540

gcgatgaagt gcgccagatt gcgccgggcc agaccggcaa aattgcggat tataactata      600

aactgccgga tgattttacc ggctgcgtga ttgcgtggaa cagcaacaac ctggatagca      660

aagtgggcgg caactataac tatctgtatc gcctgtttcg caaaagcaac ctgaaaccgt      720

ttgaacgcga tattagcacc gaaatttatc aggcgggcag caccccgtgc aacggcgtgg      780

aaggctttaa ctgctatttt ccgctgcaga gctatggctt tcagccgacc aacggcgtgg      840

gctatcagcc gtatcgcgtg gtggtgctga gctttgaact gctgcatgcg ccggcgaccg      900

tgtgcggccc gaaaaaaagc accaacctgg tgaaaaacaa atgcgtgaac tttactagtg      960

acgaggatgg aggaggtgga agcggaggag gtggatctta ttatggtaaa aggttgttat     1020

tacctgattc agtcacggaa tatgataaga aacttgtttc gcgcattcaa attcgagtta     1080

atcctttgcc gaaatttgat tcaaccgtgt gggtgacagt ccgtaaagtt cctgcctctt     1140

cggacttatc cgttgccgcc atttctgcta tgtttgcgga cggagcctca ccggtactgg     1200

tttatcagta cgctgcatct ggagtccaag ctaacaacaa actgttgtat gatctttcgg     1260

cgatgcgcgc tgatataggc gacatgagaa agtacgccgt tctcgtgtat tcaaaagacg     1320

atgcactcga gacagacgag ttagtacttc atgttgacgt cgagcaccaa cgtattccca     1380

catctggggt gctcccagtt tgataagctt                                      1410


<210>  27
<211>  72
<212>  PRT
<213>  artificial sequence

<220>
<223>  RBM SARS-CoV2

<400>  27

Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
1               5                   10                  15      


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
            20                  25                  30          


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
        35                  40                  45              


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
    50                  55                  60                  


Asn Gly Val Gly Tyr Gln Pro Tyr 
65                  70          


<210>  28
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-nCoV-M

<400>  28

Met Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Arg Arg Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25                  30          


Asp Ala Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys 
        35                  40                  45              


Thr Leu Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly 
    50                  55                  60                  


Ser Glu Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys 
65                  70                  75                  80  


Pro Pro Lys Ile Asp Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Asp Glu Asp Gly Ser Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Thr Ser Asp Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Tyr Tyr Gly Lys Arg Leu Leu Leu Pro Asp Ser Val Thr Glu Tyr 
        195                 200                 205             


Asp Lys Lys Leu Val Ser Arg Ile Gln Ile Arg Val Asn Pro Leu Pro 
    210                 215                 220                 


Lys Phe Asp Ser Thr Val Trp Val Thr Val Arg Lys Val Pro Ala Ser 
225                 230                 235                 240 


Ser Asp Leu Ser Val Ala Ala Ile Ser Ala Met Phe Ala Asp Gly Ala 
                245                 250                 255     


Ser Pro Val Leu Val Tyr Gln Tyr Ala Ala Ser Gly Val Gln Ala Asn 
            260                 265                 270         


Asn Lys Leu Leu Tyr Asp Leu Ser Ala Met Arg Ala Asp Ile Gly Asp 
        275                 280                 285             


Met Arg Lys Tyr Ala Val Leu Val Tyr Ser Lys Asp Asp Ala Leu Glu 
    290                 295                 300                 


Thr Asp Glu Leu Val Leu His Val Asp Val Glu His Gln Arg Ile Pro 
305                 310                 315                 320 


Thr Ser Gly Val Leu Pro Val 
                325         


<210>  29
<211>  993
<212>  DNA
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-nCoV-M

<400>  29
ccatgggcca gtatattaag gccaactcca aatttatcgg gattaccgag cgtcgacgtc       60

gtccgcgtcg tggttcccgc tccgccccct cctccgcgga tgctaacttt agagtcttgt      120

cgcagcagct ttcgcgactt aataagacgt tagcagctgg tcgtccaact attaaccacc      180

caacctttgt agggagtgaa cgctgtaaac ctgggtacac gttcacatct atcaccctaa      240

agccaccaaa aatagaccgt ggatctggag gaggtggtag tggtggaggt ggatctggag      300

gaggtgacga ggatggatcc aacagcaaca acctggatag caaagtgggc ggcaactata      360

actatctgta tcgcctgttt cgcaaaagca acctgaaacc gtttgaacgc gatattagca      420

ccgaaattta tcaggcgggc agcaccccgt gcaacggcgt ggaaggcttt aactgctatt      480

ttccgctgca gagctatggc tttcagccga ccaacggcgt gggctatcag ccgtatacta      540

gtgacgagga tggaggaggt ggaagcggag gaggtggatc ttattatggt aaaaggttgt      600

tattacctga ttcagtcacg gaatatgata agaaacttgt ttcgcgcatt caaattcgag      660

ttaatccttt gccgaaattt gattcaaccg tgtgggtgac agtccgtaaa gttcctgcct      720

cttcggactt atccgttgcc gccatttctg ctatgtttgc ggacggagcc tcaccggtac      780

tggtttatca gtacgctgca tctggagtcc aagctaacaa caaactgttg tatgatcttt      840

cggcgatgcg cgctgatata ggcgacatga gaaagtacgc cgttctcgtg tattcaaaag      900

acgatgcact cgagacagac gagttagtac ttcatgttga cgtcgagcac caacgtattc      960

ccacatctgg ggtgctccca gtttgataag ctt                                   993


<210>  30
<211>  211
<212>  PRT
<213>  artificial sequence

<220>
<223>  RBD MERS

<400>  30

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys 
    210     


<210>  31
<211>  466
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-MERS-D

<400>  31

Met Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Arg Arg Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25                  30          


Asp Ala Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys 
        35                  40                  45              


Thr Leu Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly 
    50                  55                  60                  


Ser Glu Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys 
65                  70                  75                  80  


Pro Pro Lys Ile Asp Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Asp Glu Asp Gly Ser Gln Ala Glu Gly Val Glu 
            100                 105                 110         


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
        115                 120                 125             


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
    130                 135                 140                 


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
145                 150                 155                 160 


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
                165                 170                 175     


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
            180                 185                 190         


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
        195                 200                 205             


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
    210                 215                 220                 


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
225                 230                 235                 240 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
                245                 250                 255     


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
            260                 265                 270         


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
        275                 280                 285             


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
    290                 295                 300                 


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Thr Ser Asp 
305                 310                 315                 320 


Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Tyr Gly Lys 
                325                 330                 335     


Arg Leu Leu Leu Pro Asp Ser Val Thr Glu Tyr Asp Lys Lys Leu Val 
            340                 345                 350         


Ser Arg Ile Gln Ile Arg Val Asn Pro Leu Pro Lys Phe Asp Ser Thr 
        355                 360                 365             


Val Trp Val Thr Val Arg Lys Val Pro Ala Ser Ser Asp Leu Ser Val 
    370                 375                 380                 


Ala Ala Ile Ser Ala Met Phe Ala Asp Gly Ala Ser Pro Val Leu Val 
385                 390                 395                 400 


Tyr Gln Tyr Ala Ala Ser Gly Val Gln Ala Asn Asn Lys Leu Leu Tyr 
                405                 410                 415     


Asp Leu Ser Ala Met Arg Ala Asp Ile Gly Asp Met Arg Lys Tyr Ala 
            420                 425                 430         


Val Leu Val Tyr Ser Lys Asp Asp Ala Leu Glu Thr Asp Glu Leu Val 
        435                 440                 445             


Leu His Val Asp Val Glu His Gln Arg Ile Pro Thr Ser Gly Val Leu 
    450                 455                 460                 


Pro Val 
465     


<210>  32
<211>  1410
<212>  DNA
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-MERS-D

<400>  32
ccatgggcca gtatattaag gccaactcca aatttatcgg gattaccgag cgtcgacgtc       60

gtccgcgtcg tggttcccgc tccgccccct cctccgcgga tgctaacttt agagtcttgt      120

cgcagcagct ttcgcgactt aataagacgt tagcagctgg tcgtccaact attaaccacc      180

caacctttgt agggagtgaa cgctgtaaac ctgggtacac gttcacatct atcaccctaa      240

agccaccaaa aatagaccgt ggatctggag gaggtggtag tggtggaggt ggatctggag      300

gaggtgacga ggatggatcc caggcggaag gcgtggaatg cgattttagc ccgctgctga      360

gcggcacccc gccgcaggtg tataacttta aacgcctggt gtttaccaac tgcaactata      420

acctgaccaa actgctgagc ctgtttagcg tgaacgattt tacctgcagc cagattagcc      480

cggcggcgat tgcgagcaac tgctatagca gcctgattct ggattatttt agctatccgc      540

tgagcatgaa aagcgatctg agcgtgagca gcgcgggccc gattagccag tttaactata      600

aacagagctt tagcaacccg acctgcctga ttctggcgac cgtgccgcat aacctgacca      660

ccattaccaa accgctgaaa tatagctata ttaacaaatg cagccgcctg ctgagcgatg      720

atcgcaccga agtgccgcag ctggtgaacg cgaaccagta tagcccgtgc gtgagcattg      780

tgccgagcac cgtgtgggaa gatggcgatt attatcgcaa acagctgagc ccgctggaag      840

gcggcggctg gctggtggcg agcggcagca ccgtggcgat gaccgaacag ctgcagatgg      900

gctttggcat taccgtgcag tatggcaccg ataccaacag cgtgtgcccg aaaactagtg      960

acgaggatgg aggaggtgga agcggaggag gtggatctta ttatggtaaa aggttgttat     1020

tacctgattc agtcacggaa tatgataaga aacttgtttc gcgcattcaa attcgagtta     1080

atcctttgcc gaaatttgat tcaaccgtgt gggtgacagt ccgtaaagtt cctgcctctt     1140

cggacttatc cgttgccgcc atttctgcta tgtttgcgga cggagcctca ccggtactgg     1200

tttatcagta cgctgcatct ggagtccaag ctaacaacaa actgttgtat gatctttcgg     1260

cgatgcgcgc tgatataggc gacatgagaa agtacgccgt tctcgtgtat tcaaaagacg     1320

atgcactcga gacagacgag ttagtacttc atgttgacgt cgagcaccaa cgtattccca     1380

catctggggt gctcccagtt tgataagctt                                      1410


<210>  33
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward ME-M BamF

<400>  33
tggatccgtg ccgcataacc tgaccaccat tac                                    33


<210>  34
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse ME-M SpeR

<400>  34
cactagtctg ttcggtcatc gccacggt                                          28


<210>  35
<211>  83
<212>  PRT
<213>  artificial sequence

<220>
<223>  RBM MERS

<400>  35

Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr 
1               5                   10                  15      


Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro 
            20                  25                  30          


Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro 
        35                  40                  45              


Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro 
    50                  55                  60                  


Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met 
65                  70                  75                  80  


Thr Glu Gln 
            


<210>  36
<211>  338
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-MERS-M

<400>  36

Met Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Arg Arg Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25                  30          


Asp Ala Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys 
        35                  40                  45              


Thr Leu Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly 
    50                  55                  60                  


Ser Glu Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys 
65                  70                  75                  80  


Pro Pro Lys Ile Asp Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Asp Glu Asp Gly Ser Val Pro His Asn Leu Thr 
            100                 105                 110         


Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg 
        115                 120                 125             


Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn 
    130                 135                 140                 


Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp 
145                 150                 155                 160 


Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp 
                165                 170                 175     


Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Thr Ser Asp 
            180                 185                 190         


Glu Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Tyr Gly Lys 
        195                 200                 205             


Arg Leu Leu Leu Pro Asp Ser Val Thr Glu Tyr Asp Lys Lys Leu Val 
    210                 215                 220                 


Ser Arg Ile Gln Ile Arg Val Asn Pro Leu Pro Lys Phe Asp Ser Thr 
225                 230                 235                 240 


Val Trp Val Thr Val Arg Lys Val Pro Ala Ser Ser Asp Leu Ser Val 
                245                 250                 255     


Ala Ala Ile Ser Ala Met Phe Ala Asp Gly Ala Ser Pro Val Leu Val 
            260                 265                 270         


Tyr Gln Tyr Ala Ala Ser Gly Val Gln Ala Asn Asn Lys Leu Leu Tyr 
        275                 280                 285             


Asp Leu Ser Ala Met Arg Ala Asp Ile Gly Asp Met Arg Lys Tyr Ala 
    290                 295                 300                 


Val Leu Val Tyr Ser Lys Asp Asp Ala Leu Glu Thr Asp Glu Leu Val 
305                 310                 315                 320 


Leu His Val Asp Val Glu His Gln Arg Ile Pro Thr Ser Gly Val Leu 
                325                 330                 335     


Pro Val 
        


<210>  37
<211>  1026
<212>  DNA
<213>  artificial sequence

<220>
<223>  CMV-Ntt830-MERS-M

<400>  37
ccatgggcca gtatattaag gccaactcca aatttatcgg gattaccgag cgtcgacgtc       60

gtccgcgtcg tggttcccgc tccgccccct cctccgcgga tgctaacttt agagtcttgt      120

cgcagcagct ttcgcgactt aataagacgt tagcagctgg tcgtccaact attaaccacc      180

caacctttgt agggagtgaa cgctgtaaac ctgggtacac gttcacatct atcaccctaa      240

agccaccaaa aatagaccgt ggatctggag gaggtggtag tggtggaggt ggatctggag      300

gaggtgacga ggatggatcc gtgccgcata acctgaccac cattaccaaa ccgctgaaat      360

atagctatat taacaaatgc agccgcctgc tgagcgatga tcgcaccgaa gtgccgcagc      420

tggtgaacgc gaaccagtat agcccgtgcg tgagcattgt gccgagcacc gtgtgggaag      480

atggcgatta ttatcgcaaa cagctgagcc cgctggaagg cggcggctgg ctggtggcga      540

gcggcagcac cgtggcgatg accgaacaga ctagtgacga ggatggagga ggtggaagcg      600

gaggaggtgg atcttattat ggtaaaaggt tgttattacc tgattcagtc acggaatatg      660

ataagaaact tgtttcgcgc attcaaattc gagttaatcc tttgccgaaa tttgattcaa      720

ccgtgtgggt gacagtccgt aaagttcctg cctcttcgga cttatccgtt gccgccattt      780

ctgctatgtt tgcggacgga gcctcaccgg tactggttta tcagtacgct gcatctggag      840

tccaagctaa caacaaactg ttgtatgatc tttcggcgat gcgcgctgat ataggcgaca      900

tgagaaagta cgccgttctc gtgtattcaa aagacgatgc actcgagaca gacgagttag      960

tacttcatgt tgacgtcgag caccaacgta ttcccacatc tggggtgctc ccagtttgat     1020

aagctt                                                                1026


<210>  38
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  part of RBD of SARS CoV2

<400>  38

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe His 
    210                 215                 220                 


His His His His His 
225                 


<210>  39
<211>  1274
<212>  PRT
<213>  artificial sequence

<220>
<223>  SARS CoV-2 S

<400>  39

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr Glx 
    1265                 1270                 


<210>  40
<211>  69
<212>  PRT
<213>  artificial sequence

<220>
<223>  RBM of SARS CoV-2 short

<400>  40

Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
1               5                   10                  15      


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
            20                  25                  30          


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
        35                  40                  45              


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
    50                  55                  60                  


Gly Val Gly Tyr Gln 
65                  


<210>  41
<211>  60
<212>  PRT
<213>  artificial sequence

<220>
<223>  60 aa fragment of RBM of SARS-CoV-2

<400>  41

Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
1               5                   10                  15      


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
            20                  25                  30          


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
        35                  40                  45              


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
    50                  55                  60  


<210>  42
<211>  68
<212>  PRT
<213>  artificial sequence

<220>
<223>  RBM of SARS-CoV

<400>  42

Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr 
1               5                   10                  15      


Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser 
            20                  25                  30          


Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu 
        35                  40                  45              


Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly 
    50                  55                  60                  


Ile Gly Tyr Gln 
65              


<210>  43
<211>  61
<212>  PRT
<213>  artificial sequence

<220>
<223>  61aa fragment of RBM of SARS-CoV

<400>  43

Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys 
1               5                   10                  15      


Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp 
            20                  25                  30          


Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn 
        35                  40                  45              


Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln 
    50                  55                  60      


