                         SEQUENCE LISTING

<110>  Oslo Universitetssykehus HF
 
<120>  Humanized antigen binding unit for targeting osteasarcoma cells

<130>  P28189PC00

<160>  117   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  TP1 VL CDR 1

<400>  1

Gln Gly Val Gly Ser Ala 
1               5       


<210>  2
<211>  3
<212>  PRT
<213>  TP1 VL CDR2

<400>  2

Trp Ala Ser 
1           


<210>  3
<211>  9
<212>  PRT
<213>  TP1 VL CDR3

<400>  3

Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  TP1 VH CDR1

<400>  4

Gly Asp Ser Ile Thr Ser Gly Tyr 
1               5               


<210>  5
<211>  7
<212>  PRT
<213>  TP1 VH CDR2

<400>  5

Ile Ser Tyr Ser Asp Thr Thr 
1               5           


<210>  6
<211>  13
<212>  PRT
<213>  TP1 VH CDR3

<400>  6

Ala Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn 
1               5                   10              


<210>  7
<211>  10
<212>  PRT
<213>  TP3 VL CDR1

<400>  7

Ser Lys Ser Val Ser Thr Gly Tyr Ser Tyr 
1               5                   10  


<210>  8
<211>  3
<212>  PRT
<213>  TP3 VL CDR2

<400>  8

Leu Ala Ser 
1           


<210>  9
<211>  9
<212>  PRT
<213>  TP3 VL CDR 3

<400>  9

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  TP3 VH CDR1

<400>  10

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  TP3 VH CDR2

<400>  11

Ile Asn Pro Asn Tyr Asp Ser Thr 
1               5               


<210>  12
<211>  18
<212>  PRT
<213>  TP3 VH CDR 3

<400>  12

Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  13
<211>  108
<212>  PRT
<213>  TP1 VL1A

<400>  13

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  108
<212>  PRT
<213>  TP1 VL1B

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  15
<211>  108
<212>  PRT
<213>  TP1 VL1C

<400>  15

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Lys Arg 
            100                 105             


<210>  16
<211>  107
<212>  PRT
<213>  TP1 VL1D

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  107
<212>  PRT
<213>  TP1 VL1E

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  107
<212>  PRT
<213>  TP1 VL1F

<400>  18

Asp Ile Gln Leu Thr Gln Ser His Arg Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  107
<212>  PRT
<213>  TP1 VL1G

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  TP1 VL1H

<400>  20

Ala Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  119
<212>  PRT
<213>  TP1 VH1A

<400>  21

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  119
<212>  PRT
<213>  TP1 VH1B

<400>  22

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  119
<212>  PRT
<213>  TP1 VH1C

<400>  23

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  24
<211>  119
<212>  PRT
<213>  TP1 VH1D

<400>  24

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  119
<212>  PRT
<213>  TP1 VH1E

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  119
<212>  PRT
<213>  TP1 VH1F

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  119
<212>  PRT
<213>  TP1 VH1G

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Arg Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  119
<212>  PRT
<213>  TP1 VH1H

<400>  28

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Lys Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ala Thr Val Ser Ser 
        115                 


<210>  29
<211>  111
<212>  PRT
<213>  TP3 VL3A

<400>  29

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110     


<210>  30
<211>  111
<212>  PRT
<213>  TP3 VL3B

<400>  30

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110     


<210>  31
<211>  111
<212>  PRT
<213>  TP3 VL3C

<400>  31

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  32
<211>  110
<212>  PRT
<213>  TP3 VL3D

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  33
<211>  110
<212>  PRT
<213>  TP3 VL3E

<400>  33

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  34
<211>  110
<212>  PRT
<213>  TP3 VL3F

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  35
<211>  110
<212>  PRT
<213>  TP3 VL3G

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  36
<211>  110
<212>  PRT
<213>  TP3 VL3H

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ile Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Arg Pro 
65                  70                  75                  80  


Leu Glu Asp Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110 


<210>  37
<211>  125
<212>  PRT
<213>  TP3 VH3A

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  125
<212>  PRT
<213>  TP3 VH3B

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  125
<212>  PRT
<213>  TP3 VH3C

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  125
<212>  PRT
<213>  TP3 VH3D

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  41
<211>  125
<212>  PRT
<213>  TP3 VH3E

<400>  41

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  42
<211>  125
<212>  PRT
<213>  TP3 VH3F

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Trp Val Thr Val Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  43
<211>  125
<212>  PRT
<213>  TP3 VH3G

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ser Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  125
<212>  PRT
<213>  TP3 VH3H

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ser His Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ser Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  45
<211>  247
<212>  PRT
<213>  VL1A-linker-VH1A

<400>  45

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210>  46
<211>  247
<212>  PRT
<213>  VL1A-linker-VH1B

<400>  46

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210>  47
<211>  247
<212>  PRT
<213>  VL1A-linker-VH1C

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  48
<211>  236
<212>  PRT
<213>  VL1B-linker-VH1A

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    130                 135                 140                 


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
145                 150                 155                 160 


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
                165                 170                 175     


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        195                 200                 205             


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
225                 230                 235     


<210>  49
<211>  247
<212>  PRT
<213>  VL1B-linker-VH1B

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210>  50
<211>  247
<212>  PRT
<213>  VL1B-linker-VH1C

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  51
<211>  247
<212>  PRT
<213>  VL1C-linker-VH1A

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210>  52
<211>  247
<212>  PRT
<213>  VL1C-linker-VH1B

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         


<210>  53
<211>  247
<212>  PRT
<213>  VL1C-linker-VH1C

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Asn Lys Leu Glu Tyr Met 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  54
<211>  248
<212>  PRT
<213>  VL1D-linker-VH1D

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Arg Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  55
<211>  248
<212>  PRT
<213>  VL1E-linker-VH1D

<400>  55

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Arg Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  56
<211>  248
<212>  PRT
<213>  VL1F-linker-VH1D

<400>  56

Asp Ile Gln Leu Thr Gln Ser His Arg Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Arg Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  57
<211>  248
<212>  PRT
<213>  VL1G-linker-VH1D

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Arg Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  58
<211>  248
<212>  PRT
<213>  VL1H-linker-VH1D

<400>  58

Ala Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Arg Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  59
<211>  248
<212>  PRT
<213>  VL1D-linker-VH1E

<400>  59

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Ser Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser Asp 
                245             


<210>  60
<211>  248
<212>  PRT
<213>  VL1E-linker-VH1E

<400>  60

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Ser Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser Asp 
                245             


<210>  61
<211>  248
<212>  PRT
<213>  VL1F-linker-VH1E

<400>  61

Asp Ile Gln Leu Thr Gln Ser His Arg Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Ser Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser Asp 
                245             


<210>  62
<211>  248
<212>  PRT
<213>  VL1G-linker-VH1E

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Ser Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser Asp 
                245             


<210>  63
<211>  248
<212>  PRT
<213>  VL1H-linker-VH1E

<400>  63

Ala Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Ile Ser Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser Asp 
                245             


<210>  64
<211>  248
<212>  PRT
<213>  VL1D-linker-VH1F

<400>  64

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  65
<211>  248
<212>  PRT
<213>  VL1E-linker-VH1F

<400>  65

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  66
<211>  248
<212>  PRT
<213>  VL1F-linker-VH1F

<400>  66

Asp Ile Gln Leu Thr Gln Ser His Arg Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  67
<211>  248
<212>  PRT
<213>  VL1G-linker-VH1F

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  68
<211>  248
<212>  PRT
<213>  VL1H-linker-VH1F

<400>  68

Ala Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  69
<211>  248
<212>  PRT
<213>  VL1D-linker-VH1G

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Arg Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  70
<211>  248
<212>  PRT
<213>  VL1E-linker-VH1G

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Arg Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  71
<211>  248
<212>  PRT
<213>  VL1F-linker-VH1G

<400>  71

Asp Ile Gln Leu Thr Gln Ser His Arg Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Arg Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  72
<211>  248
<212>  PRT
<213>  VL1G-linker-VH1G

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Arg Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  73
<211>  248
<212>  PRT
<213>  VL1H-linker-VH1G

<400>  73

Ala Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Arg Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp 
                245             


<210>  74
<211>  248
<212>  PRT
<213>  VL1D-linker-VH1H

<400>  74

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Lys Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Ala Thr Val Ser Ser Asp 
                245             


<210>  75
<211>  248
<212>  PRT
<213>  VL1E-linker-VH1H

<400>  75

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Lys Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Ala Thr Val Ser Ser Asp 
                245             


<210>  76
<211>  248
<212>  PRT
<213>  VL1F-linker-VH1H

<400>  76

Asp Ile Gln Leu Thr Gln Ser His Arg Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Lys Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Ala Thr Val Ser Ser Asp 
                245             


<210>  77
<211>  248
<212>  PRT
<213>  VL1G-linker-VH1H

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Lys Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Ala Thr Val Ser Ser Asp 
                245             


<210>  78
<211>  248
<212>  PRT
<213>  VL1H-linker-VH1H

<400>  78

Ala Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Lys Leu Lys Ser Val Thr Ala Glu Asp Thr Ala Ser Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Ala Thr Val Ser Ser Asp 
                245             


<210>  79
<211>  256
<212>  PRT
<213>  VL3A-linker-VH3A

<400>  79

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


<210>  80
<211>  256
<212>  PRT
<213>  VL3A-LINKER-VH3B

<400>  80

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


<210>  81
<211>  256
<212>  PRT
<213>  VL3A-linker-VH3C

<400>  81

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  82
<211>  256
<212>  PRT
<213>  VL3B-linker-VH3A

<400>  82

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


<210>  83
<211>  256
<212>  PRT
<213>  VL3B-linker-VH3B

<400>  83

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


<210>  84
<211>  256
<212>  PRT
<213>  VL3B-linker-VH3C

<400>  84

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  85
<211>  256
<212>  PRT
<213>  VL3C-linker-VH3A

<400>  85

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


<210>  86
<211>  256
<212>  PRT
<213>  VL3C-linker-VH3B

<400>  86

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


<210>  87
<211>  256
<212>  PRT
<213>  VL3C-linker-VHC

<400>  87

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  88
<211>  257
<212>  PRT
<213>  VL3D-linker-VH3D

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Thr 
        195                 200                 205             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  89
<211>  257
<212>  PRT
<213>  VL3E-linker-VH3D

<400>  89

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Thr 
        195                 200                 205             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  90
<211>  257
<212>  PRT
<213>  VL3F-linker-VH3D

<400>  90

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Thr 
        195                 200                 205             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  91
<211>  257
<212>  PRT
<213>  VL3G-linker-VH3D

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Thr 
        195                 200                 205             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  92
<211>  257
<212>  PRT
<213>  VL3H-linker-VH3D

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ile Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Arg Pro 
65                  70                  75                  80  


Leu Glu Asp Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Thr 
        195                 200                 205             


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  93
<211>  257
<212>  PRT
<213>  VL3D-linker-VH3E

<400>  93

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Ala Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  94
<211>  257
<212>  PRT
<213>  VL3E-linker-VH3E

<400>  94

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Ala Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  95
<211>  257
<212>  PRT
<213>  VL3F-linker-VH3E

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Ala Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  96
<211>  257
<212>  PRT
<213>  VL3G-linker-VH3E

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Ala Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  97
<211>  257
<212>  PRT
<213>  VL3H-linker-VH3E

<400>  97

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ile Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Arg Pro 
65                  70                  75                  80  


Leu Glu Asp Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Ala Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  98
<211>  257
<212>  PRT
<213>  VL3D-linker-VH3F

<400>  98

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Trp Val Thr Val Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  99
<211>  257
<212>  PRT
<213>  VL3E-linker-VH3F

<400>  99

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Trp Val Thr Val Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  100
<211>  257
<212>  PRT
<213>  VL3F-linker-VH3F

<400>  100

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Trp Val Thr Val Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  101
<211>  257
<212>  PRT
<213>  VL3G-linker-VH3F

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Trp Val Thr Val Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  102
<211>  257
<212>  PRT
<213>  VL3H-linker-VH3F

<400>  102

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ile Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Arg Pro 
65                  70                  75                  80  


Leu Glu Asp Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Trp Val Thr Val Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  103
<211>  257
<212>  PRT
<213>  VL3D-linker-VH3G

<400>  103

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  104
<211>  257
<212>  PRT
<213>  VL3E-linker-VH3G

<400>  104

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  105
<211>  257
<212>  PRT
<213>  VL3F-linker-VH3G

<400>  105

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  106
<211>  257
<212>  PRT
<213>  VL3G-linker-VH3G

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  107
<211>  257
<212>  PRT
<213>  VL3H-linker-VH3G

<400>  107

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ile Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Arg Pro 
65                  70                  75                  80  


Leu Glu Asp Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Arg Asp Thr Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  108
<211>  257
<212>  PRT
<213>  VL3D-linker-VH3H

<400>  108

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ser His Gly Arg Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Val Asp Lys Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  109
<211>  257
<212>  PRT
<213>  VL3E-linker-VH3H

<400>  109

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ser His Gly Arg Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Val Asp Lys Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  110
<211>  257
<212>  PRT
<213>  VL3F-linker-VH3H

<400>  110

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ser His Gly Arg Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Val Asp Lys Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  111
<211>  257
<212>  PRT
<213>  VL3G-linker-VH3H

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ser His Gly Arg Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Val Asp Lys Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  112
<211>  257
<212>  PRT
<213>  VL3H-linker-VH3H

<400>  112

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ile Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Arg Pro 
65                  70                  75                  80  


Leu Glu Asp Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Asn Met Asp Trp Val Arg Gln Ser His Gly Arg Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Arg Val Thr Ser Thr Val Asp Lys Ser Ile Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Val Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp 
225                 230                 235                 240 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255     


Asp 
    


<210>  113
<211>  108
<212>  PRT
<213>  murine parent VL TP1

<400>  113

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Gly Val Gly Ser Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Thr Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  114
<211>  120
<212>  PRT
<213>  murine parent VH TP1

<400>  114

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Asp Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


His Leu Lys Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ala Tyr Tyr Gly Ser Ser Leu Ser Met Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ala Thr Val Ser Ser Asp 
        115                 120 


<210>  115
<211>  110
<212>  PRT
<213>  murine parent VL TP3

<400>  115

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
65                  70                  75                  80  


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110 


<210>  116
<211>  125
<212>  PRT
<213>  murine parent VH TP3

<400>  116

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Val Ser Ser Tyr Gly His Asp Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  117
<211>  20
<212>  PRT
<213>  Leader peptide

<400>  117

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


