               SEQUENCE LISTING

<110> CEA

<120> Vasopressin-2 receptor antagonist peptides and uses thereof

<130> PR89992

<150> EP20305696
<151> 2020-06-24

<160> 25

<170> BiSSAP 1.3.2

<210> 1
<211> 57
<212> PRT
<213> Artificial Sequence

<223> X1, X2, X3, X4, X5 and X6 are as defined.

<220> 
<223> X1, X2, X3, X4, X5 and X6 are as defined.

<220> 
<221> VARIANT
<222> 4
<223> X1 means the amino acid residue F or G

<220> 
<221> VARIANT
<222> 15
<223> X2 means any amino acid residue, excepted a basic amino acid

<220> 
<221> VARIANT
<222> 27
<223> X3 means the amino acid residue T or D

<220> 
<221> VARIANT
<222> 48
<223> X4 means the amino acid residue I, L or E

<220> 
<221> VARIANT
<222> 56..57
<223> (i) X5 means V and X6 means G or (ii) X5 means G and X6 means V

<400> 1
Arg Pro Ser Xaa Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Xaa Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Xaa Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Ala Gly Asn Ala Asn Arg Phe Ser Thr Xaa 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Xaa Xaa 
    50                  55          

<210> 2
<211> 57
<212> PRT
<213> Artificial Sequence

<223> K39A

<220> 
<223> K39A

<400> 2
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Ala Gly Asn Ala Asn Arg Phe Ser Thr Ile 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 3
<211> 57
<212> PRT
<213> Artificial Sequence

<223> K39A+I48L

<220> 
<223> K39A+I48L

<400> 3
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Ala Gly Asn Ala Asn Arg Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 4
<211> 57
<212> PRT
<213> Artificial Sequence

<223> N15A+K39A+I48L

<220> 
<223> N15A+K39A+I48L

<400> 4
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Ala Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Ala Gly Asn Ala Asn Arg Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 5
<211> 57
<212> PRT
<213> Artificial Sequence

<223> F4G K39A T27D

<220> 
<223> F4G K39A T27D

<400> 5
Arg Pro Ser Gly Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Asp Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Ala Gly Asn Ala Asn Arg Phe Ser Thr Ile 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 6
<211> 57
<212> PRT
<213> Artificial Sequence

<223> MQ-LEAD F4G+K39A+T27D+I48E

<220> 
<223> MQ-LEAD F4G+K39A+T27D+I48E

<400> 6
Arg Pro Ser Gly Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Asp Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Ala Gly Asn Ala Asn Arg Phe Ser Thr Glu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 7
<211> 57
<212> PRT
<213> Artificial Sequence

<223> WT MQ1 peptide

<220> 
<223> WT MQ1 peptide

<400> 7
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Asn Ala Asn Arg Phe Ser Thr Ile 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 8
<211> 57
<212> PRT
<213> Artificial Sequence

<223> K10A

<220> 
<223> K10A

<400> 8
Arg Pro Ser Phe Cys Asn Leu Pro Val Ala Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Asn Ala Asn Arg Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 9
<211> 57
<212> PRT
<213> Artificial Sequence

<223> K10E

<220> 
<223> K10E

<400> 9
Arg Pro Ser Phe Cys Asn Leu Pro Val Glu Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Asn Ala Asn Arg Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 10
<211> 57
<212> PRT
<213> Artificial Sequence

<223> F17A

<220> 
<223> F17A

<400> 10
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Ala Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Asn Ala Asn Arg Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 11
<211> 57
<212> PRT
<213> Artificial Sequence

<223> F18A

<220> 
<223> F18A

<400> 11
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Ala Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Asn Ala Asn Arg Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 12
<211> 57
<212> PRT
<213> Artificial Sequence

<223> N41A

<220> 
<223> N41A

<400> 12
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Ala Ala Asn Arg Phe Ser Thr Ile 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 13
<211> 57
<212> PRT
<213> Artificial Sequence

<223> R44A

<220> 
<223> R44A

<400> 13
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Asn Ala Asn Ala Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 14
<211> 57
<212> PRT
<213> Artificial Sequence

<223> R44E

<220> 
<223> R44E

<400> 14
Arg Pro Ser Phe Cys Asn Leu Pro Val Lys Pro Gly Pro Cys Asn Gly 
1               5                   10                  15      
Phe Phe Ser Ala Phe Tyr Tyr Ser Gln Lys Thr Asn Lys Cys His Ser 
            20                  25                  30          
Phe Thr Tyr Gly Gly Cys Lys Gly Asn Ala Asn Glu Phe Ser Thr Leu 
        35                  40                  45              
Glu Lys Cys Arg Arg Thr Cys Val Gly 
    50                  55          

<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 1
<223> (7-Methoxycoumarin-4-yl) acetyl

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 9
<223> 2, 4-Dinitrophenyl

<400> 15
Arg Pro Pro Gly Phe Ser Ala Phe Lys 
1               5                   

<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 1
<223> (7-Methoxycoumarin-4-yl) acetyl

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 7
<223> 2, 4-Dinitrophenyl

<400> 16
Tyr Val Ala Asp Ala Pro Lys 
1               5           

<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 1
<223> (7-Methoxycoumarin-4-yl) acetyl

<220> 
<223> Enzyme substrate

<220> 
<221> NON_STD
<222> 7
<223> X is N-3-(2,4-dinitrophenyl)-L-alpha,beta-diaminopropionyl]

<400> 17
Pro Leu Ala Gln Ala Val Xaa Arg Ser Ser Ser Arg 
1               5                   10          

<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 1
<223> (7-Methoxycoumarin-4-yl) acetyl

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 11
<223> 2, 4-Dinitrophenyl

<400> 18
Ser Glu Val Asn Leu Asp Ala Glu Phe Arg Lys Arg Arg 
1               5                   10              

<210> 19
<211> 4
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> MOD_RES
<222> 1
<223> Acetyl ACETYLATION

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 4
<223> 7-amino-4-methyl coumarin

<400> 19
Leu Glu His Asp 
1               

<210> 20
<211> 4
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> MOD_RES
<222> 1
<223> Acetyl ACETYLATION

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 4
<223> 7-amino-4-methyl coumarin

<400> 20
Asp Glu Val Asp 
1               

<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> MOD_RES
<222> 1
<223> Acetyl ACETYLATION

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 4
<223> 7-amino-4-methyl coumarin

<400> 21
Trp Glu His Asp 
1               

<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 1
<223> (7-Methoxycoumarin-4-yl) acetyl

<220> 
<223> Enzyme substrate

<220> 
<221> NON_STD
<222> 5
<223> N-3-(2,4-dinitrophenyl)-L-alpha,beta-diaminopropionyl] linked to
      2, 4-Dinitrophenyl

<400> 22
Pro Leu Gly Leu Xaa Ala Arg 
1               5           

<210> 23
<211> 4
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> NON_STD
<222> 1
<223> Succinyl

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 4
<223> 7-amino-4-methyl coumarin

<400> 23
Ala Ala Pro Phe 
1               

<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> NON_STD
<222> 1
<223> Methoxysuccinyl

<220> 
<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 4
<223> 7-amino-4-methyl coumarin

<400> 24
Ala Ala Pro Val 
1               

<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<223> Enzyme substrate

<220> 
<221> CHAIN
<222> 1
<223> (7-Methoxycoumarin-4-yl) acetyl

<220> 
<223> Enzyme substrate

<220> 
<221> NON_STD
<222> 7
<223> X is Norvaline

<220> 
<221> CHAIN
<222> 10
<223> 2, 4-Dinitrophenyl

<400> 25
Arg Pro Lys Pro Val Glu Xaa Trp Arg Lys 
1               5                   10  

