                         SEQUENCE LISTING

<110>  Sapreme Technologies B.V.
       Charit - Universittsmedizin Berlin
 
<120>   COMBINATION COMPRISING AN ADC OR AN AOC COMPRISING A VHH, AND A
       SAPONIN OR A LIGAND-SAPONIN CONJUGATE

<130>  P6094578PCT1

<150>  NL 2025901
<151>  2020-06-24

<150>  PCT/EP2020/069338
<151>  2020-07-09

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  414
<212>  DNA
<213>  Camelus dromedarius

<400>  1
gaagttcagc tgcaggaatc tggtggtggt ctggttcagc cgggtggttc tctgcgtctg       60

tcttgcgcgg cgtctggttt catcttctct aacgacgcga tgacctgggt tcgtcaggcg      120

ccgggtaaag gtctggaatg ggtttcttct atcaactggt ctggtaccca caccaactac      180

gcggactctg ttaaaggtcg tttcaccatc tctcgtgaca acgcgaaacg taccctgtac      240

ctgcagatga actctctgaa agacgaagac accgcgctgt actactgcgt taccggttac      300

ggtgttacca aaaccccgac cggtcagggt acccaggtta ccgtttcttc tcaccaccac      360

caccaccact ctccgtctac cccgccgacc ccgtctccgt ctaccccgcc gtgc            414


<210>  2
<211>  138
<212>  PRT
<213>  Camelus dromedarius

<400>  2

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Asp 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Asp Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Thr Gly Tyr Gly Val Thr Lys Thr Pro Thr Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser His His His His His His Ser Pro Ser Thr Pro 
        115                 120                 125             


Pro Thr Pro Ser Pro Ser Thr Pro Pro Cys 
    130                 135             


<210>  3
<211>  375
<212>  DNA
<213>  Camelus dromedarius

<400>  3
atggaagttc agctggttga atctggtggt ggtctggttc aggcgggtgg ttctctgcgt       60

ctgtcttgcg cggcgtctgg tatcaccttc tctatcaaca ccatgggttg gtaccgtcag      120

gcgccgggta aacagcgtga actggttgcg ctgatctctt ctatcggtga cacctactac      180

gcggactctg ttaaaggtcg tttcaccatc tctcgtgaca acgcgaaaaa caccgtttac      240

ctgcagatga actctctgaa accggaagac accgcggttt actactgcaa acgtttccgt      300

accgcggcgc agggtaccga ctactggggt cagggtaccc aggttaccgt ttcttctcac      360

caccaccacc accac                                                       375


<210>  4
<211>  125
<212>  PRT
<213>  Camelus dromedarius

<400>  4

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile 
            20                  25                  30          


Asn Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Arg Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser His His His His His His 
        115                 120                 125 


<210>  5
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amino-acid coding DNA sequence of Anti-HER2 dsAb pcNB2

<400>  5
atggaagttc agctggttga aaaaggtggt ggtcgtgttc aggcgggtgg ttctctgcgt       60

ctgcgttgcg cggcgtctgg tatcaccttc tctatcaaca ccatgggttg gtaccgtcag      120

gcgccgggta aacagcgtga actggttgcg ctgatctctt ctatcggtga cacctactac      180

gcggactctg ttaaaggtcg tttccgtatc cgtcgtgaca acgcgaaaaa caccgtttac      240

ctgcgtatgc gtcgtctgaa accggaagac accgcggttt actactgcaa acgtttccgt      300

accgcggcgc agggtaccga ctactggggt cagggtaccc gtgttaccgt ttctaaacac      360

caccaccacc accac                                                       375


<210>  6
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-HER2 dsAb pcNB2

<400>  6

Met Glu Val Gln Leu Val Glu Lys Gly Gly Gly Arg Val Gln Ala Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Arg Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile 
            20                  25                  30          


Asn Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Arg Ile Arg Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Arg Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Arg Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Arg Val Thr Val Ser Lys His His His His His His 
        115                 120                 125 


<210>  7
<211>  378
<212>  DNA
<213>  Camelus dromedarius

<400>  7
gcggcgcagg ttaaactgga agaatctggt ggtggttctg ttcagaccgg tggttctctg       60

cgtctgacct gcgcggcgtc tggtcgtacc tctcgttctt acggtatggg ttggttccgt      120

caggcgccgg gtaaagaacg tgaattcgtt tctggtatct cttggcgtgg tgactctacc      180

ggttacgcgg actctgttaa aggtcgtttc accatctctc gtgacaacgc gaaaaacacc      240

gttgacctgc agatgaactc tctgaaaccg gaagacaccg cgatctacta ctgcgcggcg      300

gcggcgggtt ctgcgtggta cggtaccctg tacgaatacg actactgggg tcagggtacc      360

caggttaccg tttcttct                                                    378


<210>  8
<211>  126
<212>  PRT
<213>  Camelus dromedarius

<400>  8

Ala Ala Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg 
            20                  25                  30          


Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  9
<211>  381
<212>  DNA
<213>  Camelus dromedarius

<400>  9
gaagttcagc tggttgaatc tggtggtggt ctggttcagg cgggtggttc tctgcgtctg       60

tcttgcgcgg cgtctggtcg taccttctct tcttacgcga tgggttggtt ccgtcaggcg      120

ccgggtaaag aacgtgaatt cgttgttgcg atcaactggt cttctggttc tacctactac      180

gcggactctg ttaaaggtcg tttcaccatc tctcgtgaca acgcgaaaaa caccatgtac      240

ctgcagatga actctctgaa accggaagac accgcggttt actactgcgc ggcgggttac      300

cagatcaact ctggtaacta caacttcaaa gactacgaat acgactactg gggtcagggt      360

acccaggtta ccgtttcttc t                                                381


<210>  10
<211>  127
<212>  PRT
<213>  Camelus dromedarius

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  11
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amino-acid coding DNA sequence of Anti-VGFR2 dsAb NTV1

<400>  11
atggcgcagg ttcagctgct ggaatctggt ggtggtctgg ttcagccggg tggttctctg       60

cgtctgtctt gcgcggcgtc tggttactct gttatcaacg acttcatgac ctgggttcgt      120

caggcgccgg gtaaaggtct ggaatgggtt tcttctatct ctgttgcgga cggttctacc      180

tactacgcgg actctgttaa aggtcgtttc accatctctc gtgacaactc taaaaacacc      240

ctgtacctgc agatgaactc tctgcgtgcg gaagacaccg cggtttacta ctgcgcggcg      300

cgtgttggtg gtcgtgacct gggttggccg tacgaactgg actactgggg tcagggtacc      360

ctggttaccg tttcttct                                                    378


<210>  12
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-VGFR2 dsAb NTV1

<400>  12

Met Ala Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Val Ile 
            20                  25                  30          


Asn Asp Phe Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ser Ile Ser Val Ala Asp Gly Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Val Gly Gly Arg Asp Leu Gly Trp Pro Tyr Glu 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  13
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amino-acid coding DNA sequence of Anti-VGFR2 dsAb NTV2

<400>  13
atggcgcagg ttcagctgct ggaatctggt ggtggtctgg ttcagccggg tggttctctg       60

cgtctgtctt gcgcggcgtc tggtttcaaa atcaccaaca aaaccatggc gtgggttcgt      120

caggcgccgg gtaaaggtct ggaatgggtt tcttctatcg gttcttcttc tggttctacc      180

tactacgcgg actctgttaa aggtcgtttc accatctctc gtgacaactc taaaaacacc      240

ctgtacctgc agatgaactc tctgcgtgcg gaagacaccg cggtttacta ctgcgcgcgt      300

cgtaaaggta accgtctggg tccggcggcg ctgcgttctt ggggtcaggg taccctggtt      360

accgtttctt ct                                                          372


<210>  14
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-VGFR2 dsAb NTV2

<400>  14

Met Ala Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr 
            20                  25                  30          


Asn Lys Thr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ser Ile Gly Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Arg Lys Gly Asn Arg Leu Gly Pro Ala Ala Leu Arg 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amino-acid coding DNA sequence of Anti-VGFR2 dsAb NTV3

<400>  15
atggcgcagg ttcagctgct ggaatctggt ggtggtctgg ttcagccggg tggttctctg       60

cgtctgtctt gcgcggcgtc tggtgttcgt gttaactaca aatctatgtc ttgggttcgt      120

caggcgccgg gtaaaggtct ggaatgggtt tctaccatca cctctcgtaa cggttctacc      180

tactacgcgg actctgttaa aggtcgtttc accatctctc gtgacaactc taaaaacacc      240

ctgtacctgc agatgaactc tctgcgtgcg gaagacaccg cggtttacta ctgcgcgacc      300

ggtcgtgcgc accacgcgcc ggttcgttac tggggtcagg gtaccctggt taccgtttct      360

tct                                                                    363


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-VGFR2 dsAb NTV3

<400>  16

Met Ala Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Arg Val Asn 
            20                  25                  30          


Tyr Lys Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Thr Ile Thr Ser Arg Asn Gly Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gly Arg Ala His His Ala Pro Val Arg Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amino-acid coding DNA sequence of Anti-VGFR2 dsAb NTV4

<400>  17
atggcgcagg ttcagctgct ggaatctggt ggtggtctgg ttcagccggg tggttctctg       60

cgtctgtctt gcgcggcgtc tggtgttacc atcaccgacg aagacatgac ccgtgttcgt      120

caggcgccgg gtaaaggtct ggaatgggtt tcttctatcc tgaacaccgg tggttctacc      180

tactacgcgg actctgttaa aggtcgtttc accatctctc gtgacaactc taaaaacacc      240

ctgtacctgc agatgaactc tctgcgtgcg gaagacaccg cggtttacta ctgcgcggcg      300

gttcacgaaa aagcggcgga catgaacttc tggggtcagg gtaccctggt taccgtttct      360

tct                                                                    363


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-VGFR2 dsAb NTV4

<400>  18

Ala Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Ile Thr Asp 
            20                  25                  30          


Glu Asp Met Thr Arg Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ser Ile Leu Asn Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Val His Glu Lys Ala Ala Asp Met Asn Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  327
<212>  DNA
<213>  Camelus bactrianus

<400>  19
gaagttcagc tgctggaatc tggtggtggt ctggttcagc cgggtggttc tctgcgttct       60

tgcgaagcgt ctggtttcaa cgcgatgacc tctatcgact cttggaccga cgcggttaaa      120

ggttgggttc gtcagccgcc gggtaaaggt ctggaatggg tttctcgttt cgcgatctct      180

caggacaacg cgaaaaacac cgtttacctg cagatgaact ctctgaaacc ggaagacacc      240

gcgatgtact actgcgcgct gtctaaatgc tacacccgtg tttacgacta ctggggtcag      300

ggtacccagg ttaccgtttc ttctggt                                          327


<210>  20
<211>  108
<212>  PRT
<213>  Camelus bactrianus

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ser Cys Glu Ala Ser Gly Phe Asn Ala Met Thr Ser Ile 
            20                  25                  30          


Asp Ser Trp Thr Asp Ala Val Lys Gly Trp Val Arg Gln Pro Pro Gly 
        35                  40                  45              


Lys Gly Leu Glu Trp Val Ser Arg Phe Ala Ile Ser Gln Asp Asn Ala 
    50                  55                  60                  


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
65                  70                  75                  80  


Ala Met Tyr Tyr Cys Ala Leu Ser Lys Cys Tyr Thr Arg Val Tyr Asp 
                85                  90                  95      


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 


<210>  21
<211>  312
<212>  DNA
<213>  Camelus bactrianus

<400>  21
gaagttcagc tgcaggaatc tggtggtggt ctggttcagc cgggtggttc tctgcgtctg       60

tcttgcgcgg cgtctggttt catctacatg gttggtatca aaaccgaacg tgacggtgtt      120

aaaggttggg ttcgtcaggc gccgggtaaa ggtctggaat ggctgtctcg tttcaccatc      180

ccgcgtgaca acgcgaaaaa caccctgtac ctgcagatga acaacctgaa atctgaagac      240

accgcgctgt actactgcgc gaccgaagaa aacgactggg gtcagggtac ccaggttacc      300

gtttcttctg gt                                                          312


<210>  22
<211>  103
<212>  PRT
<213>  Camelus bactrianus

<400>  22

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Tyr Met Val Gly 
            20                  25                  30          


Ile Lys Thr Glu Arg Asp Gly Val Lys Gly Trp Val Arg Gln Ala Pro 
        35                  40                  45              


Gly Lys Gly Leu Glu Trp Leu Ser Arg Phe Thr Ile Pro Arg Asp Asn 
    50                  55                  60                  


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp 
65                  70                  75                  80  


Thr Ala Leu Tyr Tyr Cys Ala Thr Glu Glu Asn Asp Trp Gly Gln Gly 
                85                  90                  95      


Thr Gln Val Thr Val Ser Ser 
            100                 


<210>  23
<211>  351
<212>  DNA
<213>  Camelus dromedarius

<400>  23
caggttcagc tgcaggaatc tggtggtggt tctgttcagg cgggtggttc tctgcgtctg       60

tcttgcaccg cgtctggttt cggtgttgac ggtaccgaca tgggttggta ccgtcaggcg      120

ccgggtaacg aatgcgaact ggtttcttct atctcttcta tcggtatcgg ttactactct      180

gaatctgtta aaggtcgttt caccatctct cgtgacaacg cgaaaaacac cgtttacctg      240

cagatgaact ctctgcgtcc ggacgacacc gcggtttact actgcggtcg tcgttggatc      300

ggttaccgtt gcggtaactg gggtcgtggt acccaggtta ccgtttcttc t               351


<210>  24
<211>  117
<212>  PRT
<213>  Camelus dromedarius

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Gly Val Asp Gly Thr 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Cys Glu Leu Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ile Gly Ile Gly Tyr Tyr Ser Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Arg Trp Ile Gly Tyr Arg Cys Gly Asn Trp Gly Arg Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  369
<212>  DNA
<213>  Camelus dromedarius

<400>  25
caggttcagc tgcaggaatc tggtggtggt tctgttcagg cgggtggttc tctgcgtctg       60

tcttgcaccg gttctcgtta cacctacacc atgggttggt tccgtcaggc gccgggtaaa      120

gaacgtgaag gtgttgttgc gatcaccgcg ttcggttctc cgttctacgc ggactctgtt      180

aaaggtcgtt tcaccatctc tcgtgacaac gcgaacaaca ccatcttcct gcagatgaac      240

tctctgaaac cggaagactc tgcgatgtac tactgcgcgg cgcgtggttc ttctggtacc      300

tcttacaaat ggaacgaata cggttcttac aactactggg gtcagggtac ccaggttacc      360

gtttcttct                                                              369


<210>  26
<211>  123
<212>  PRT
<213>  Camelus dromedarius

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Arg Tyr Thr Tyr Thr Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Val Ala Ile 
        35                  40                  45              


Thr Ala Phe Gly Ser Pro Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Ile Phe Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Tyr Cys Ala Ala Arg Gly 
                85                  90                  95      


Ser Ser Gly Thr Ser Tyr Lys Trp Asn Glu Tyr Gly Ser Tyr Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  27
<211>  351
<212>  DNA
<213>  Camelus dromedarius

<400>  27
caggttcagc tgcaggaatc tggtggtggt tctgttcagg cgggtggttc tctgcgtctg       60

tcttgcgcgg cgtctaaata cacctcttgc atgggttggt tccgtcaggc gccgggtaaa      120

gaacgtgaag ttgttgcgca catcgactct ggtccgcgta ccctgtacgc ggactctgtt      180

aaaggtcgtt tcaccatctc taaagacaac gcgaaaaaca ccctgtacct ggaaatgtct      240

accctgaaac cggacgacac cgcgatgtac tactgcgcgg cgggtccgat gtactctggt      300

tcttgcaact acaactactg gggtcagggt acccaggtta ccgtttcttc t               351


<210>  28
<211>  117
<212>  PRT
<213>  Camelus dromedarius

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Tyr Thr Ser Cys Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val Ala His Ile 
        35                  40                  45              


Asp Ser Gly Pro Arg Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Ser 
65                  70                  75                  80  


Thr Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala Ala Gly Pro 
                85                  90                  95      


Met Tyr Ser Gly Ser Cys Asn Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  29
<211>  366
<212>  DNA
<213>  Camelus dromedarius

<400>  29
caggttcagc tgcaggaatc tggtggtggt ctggttcagc cgggtggttc tctgcgtctg       60

tcttgcgcgg cgtctggttt caccctggac tactacgcga tcggttggtt ccgtcaggcg      120

ccgggtaaag aacgtgaagg tgtttcttgc atctcttctt ctgacggttc tacctactac      180

gcggactctg ttaaaggtcg tttcaccatc tctcgtgaca acgcgaaaaa caccgtttac      240

ctgcagatgt cttctctgaa accggaagac accgcggttt actactgcgg tatctctggt      300

tcttgcctgc tggaagacta cggtatggac tactggggta aaggtaccca ggttaccgtt      360

tcttct                                                                 366


<210>  30
<211>  122
<212>  PRT
<213>  Camelus dromedarius

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ile Ser Gly Ser Cys Leu Leu Glu Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  378
<212>  DNA
<213>  Camelus dromedarius

<400>  31
caggttcagc tgcaggaatc tggtggtggt ctggttcacc cgggtggttc tctgcgtctg       60

tcttgcgcgg cgtctggttt ctctctggac aactacgcga tcggttggtt ccgtcaggcg      120

ccgggtaaag aacgtgaagg tgtttcttgc atctcttctg gttctgaagg tcgtcgttac      180

tacgcggact tcgttaaagg tcgtttcacc atctctcgtg acaacgcgaa aaacaccgcg      240

ttcctgcaga tgaactctct gaaaccggaa gacaccgcgg actactactg cgcgaccgtt      300

ggtttctgct cttctcagta cggtatggaa ttcgttggtg actactgggg tcagggtacc      360

caggttaccg tttcttct                                                    378


<210>  32
<211>  126
<212>  PRT
<213>  Camelus dromedarius

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Gly Ser Glu Gly Arg Arg Tyr Tyr Ala Asp Phe 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Val Gly Phe Cys Ser Ser Gln Tyr Gly Met Glu Phe Val 
            100                 105                 110         


Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  33
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Amino-acid sequence of Anti-mouse serum albumin dsAb MSA21

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Leu Gly Asp Ser Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Asn Pro Gly Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  34
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-human serum albumin dsAb Alb-1

<400>  34

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  35
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-human serum albumin dsAb Alb23

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  36
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-EGFR VHH 7A5

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Arg Thr Phe Ser Ser Asn 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Gly Leu Glu Thr His Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ser Ser Thr Arg Thr Val Ile Tyr Thr Leu Pro Arg Met Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-EGFR VHH 7D12

<400>  37

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  38
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-EGFR VHH 7C12

<400>  38

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Thr Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  39
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-insulin-like growth factor 1 receptor
       VHH 4B11

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Thr Phe Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ile Ser Gly Gly Ser Thr His Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Lys Lys Phe Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  40
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-insulin-like growth factor 1 receptor
       VHH 3G7

<400>  40

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Ser Ile Ser Thr Ile Asn 
            20                  25                  30          


Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Arg Ser Gly Arg Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Leu Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Thr Ile Asp Gly Ser Trp Arg Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  41
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-insulin-like growth factor 1 receptor
       VHH 2C7

<400>  41

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asn Trp Asn Ser Arg Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Leu Asn Ala Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Asp Cys Ala Ala Ser His Asp Ser Asp Tyr Gly Gly Thr Asn Ala Asn 
            100                 105                 110         


Leu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  42
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-insulin-like growth factor 1 receptor
       VHH 1C7

<400>  42

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Arg Thr 
            20                  25                  30          


Ala Asn Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Thr Trp Asn Ser Gly Thr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Phe Ile Ser Lys Asp Ser Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Ala Ala Ala Val Ile Thr Pro Thr Arg Gly Tyr Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  43
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CEACAM VHH NbCEA5

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  44
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CEACAM VHH CEA5

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CD123 VHH 57A07

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp 
        35                  40                  45              


Val Ala Ala Ile Ala Ser Gly Gly Ser Ile Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser His Pro Pro Thr Leu Pro Tyr Trp Gly Leu Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  46
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CD123 VHH 57B04

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asn Phe Arg Phe Asn 
            20                  25                  30          


Ser Met Gly Trp Trp Arg Arg Arg Ala Pro Gly Lys Glu Arg Glu Trp 
        35                  40                  45              


Val Ala Ala Ile Thr Ser Gly Asp Ile Thr Asn Tyr Arg Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Thr Phe Pro Pro Ile Ala Asp Tyr Trp Gly Leu Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  47
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CD123 VHH 51D09

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Ala Ile Leu Leu Tyr Arg Leu Tyr Gly Tyr Glu Glu Gly Asp Tyr 
            100                 105                 110         


Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  48
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CD123 VHH 55C05

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Pro Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Ser Leu Asn Thr Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Cys Glu Glu Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Asn Gly Val Tyr Arg Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Glu Thr Ala Ser Arg Asp Asn Ala Met Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Ala Thr Gln Gly Trp Asp Arg His Thr Glu Pro Ser Asp Phe 
            100                 105                 110         


Gly Ser Trp Gly Leu Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CD123 VHH 50F07

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Ser Thr Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Arg Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Ile Ser Ala Gly Thr Ala Phe Trp Leu Trp Ser Asp Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  50
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CD123 VHH 55F03

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Tyr Trp Ser Asn Gly Lys Thr Gln Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ala Asp Lys Asp Glu Thr Gly Phe Arg Thr Leu Pro Ile Ala Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Leu Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  51
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-CD123 VHH 55A01

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Arg Ala Leu Asn Met Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Ser Ser Ser Gly Gly Ser Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Arg Cys 
                85                  90                  95      


Ala Ala Ser Pro Tyr Val Ser Thr Pro Thr Met Asn Ile Leu Glu Glu 
            100                 105                 110         


Tyr Arg Tyr Trp Gly Leu Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  52
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-c-MET VHH 04E09

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Asp Ala Ser Asp Asp Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Ile Gly Leu Ser Ser Ser Cys Leu Leu Glu Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  53
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-c-MET VHH 06B08

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser Arg Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Asp Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Pro Asn Thr Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Tyr Arg Ser Gly Ser Tyr Tyr Gln Ala Ser Glu Trp Thr 
            100                 105                 110         


Arg Pro Ser Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  54
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-c-MET VHH 06C12

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Tyr Phe 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Ile 
        35                  40                  45              


Ser Cys Ile Ser Asn Ser Asp Gly Ser Thr Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ile Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Val Gly Leu Gly Pro Phe Cys Lys Thr Thr Asn Asp Tyr 
            100                 105                 110         


Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  55
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-c-MET VHH 06F10

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Asn Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Gly Gly Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Leu Gly Leu Ser Ser Ser Cys His Gly Asp Gly Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  56
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-Her3 VHH 21F6

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Tyr Leu Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Trp Ser Asp Gly Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Pro Pro Trp Gly Pro Met Ile Tyr Ile Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-Her3 VHH 4C7

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Ala Trp Val 
        35                  40                  45              


Ser Thr Val Ser Pro Gly Gly Ile Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Asp Leu Asn Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  58
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-Her3 VHH 17B5

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gly Leu Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Phe Gly Val Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Met Ser Ser Val Thr Arg Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  59
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-Her3 VHH 18G11

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Leu Phe Lys Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Ser Ser Asp Thr Thr Asp Tyr Ala Glu Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Trp Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ser Asp His Tyr Ser Met Gly Val Pro Glu Lys Arg Val Ile Met Tyr 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  60
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino-acid sequence of Anti-Her3 VHH 34C7

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Thr Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Trp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Asp His Tyr Thr Thr Trp Asp Arg Arg Ser Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  119
<212>  PRT
<213>  Lama glama

<400>  61

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Gly Phe Asn 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Ser Arg Val Gly Val Thr Ser Ser Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Val Asn Ala Lys Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Met Asp Gln Arg Leu Asp Gly Ser Thr Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  62
<211>  124
<212>  PRT
<213>  Lama glama

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Trp Arg Asp Ala Gly Thr Thr Trp Phe Glu Lys Ser Gly 
            100                 105                 110         


Ser Ala Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  63
<211>  118
<212>  PRT
<213>  Lama glama

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Arg Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  64
<211>  118
<212>  PRT
<213>  Lama glama

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Ser Leu Asp Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Gln Gly Trp Lys Ile Val Pro Thr Asn Pro Arg Gly His Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  65
<211>  118
<212>  PRT
<213>  Lama glama

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Ser Leu Asp Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Gln Gly Trp Lys Ile Arg Pro Thr Ile Pro Met Gly His Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  66
<211>  118
<212>  PRT
<213>  Lama glama

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu Asp Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Asp Tyr Thr Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Arg Gly Trp Lys Ile Val Pro Thr Asp Leu Gly Gly His Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  67
<211>  122
<212>  PRT
<213>  Lama glama

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Ser Asn 
            20                  25                  30          


Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Thr Ile Asn Trp Ser Gly Ser His Ser Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Pro Gly Trp Gly Thr Ala Pro Leu Ser Thr Ser Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  68
<211>  119
<212>  PRT
<213>  Lama glama

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Ser Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Tyr Asp Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Trp Gly Thr Gly Arg Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  119
<212>  PRT
<213>  Lama glama

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Ser Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Tyr Asp Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Trp Gly Thr Gly Arg Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  120
<212>  PRT
<213>  Lama glama

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Ala Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Ile Ser Arg Ser Pro Gly Val Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Asp Phe Tyr Leu Ala Thr Leu Ala His Glu Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  71
<211>  122
<212>  PRT
<213>  Lama glama

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Thr Glu Arg Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Arg Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Tyr Val Ser Thr Leu Ala His Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  72
<211>  122
<212>  PRT
<213>  Lama glama

<400>  72

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Thr Glu Arg Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Arg Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ala Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Tyr Val Ser Thr Leu Ala His Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  73
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalent VHHEGFR-dianthin-Cys

<400>  73

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Val Ala Ile Asn Trp Ser Ser Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn 
225                 230                 235                 240 


Tyr Asn Phe Lys Asp Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            260                 265                 270         


Ala Ala Thr Ala Tyr Thr Leu Asn Leu Ala Asn Pro Ser Ala Ser Gln 
        275                 280                 285             


Tyr Ser Ser Phe Leu Asp Gln Ile Arg Asn Asn Val Arg Asp Thr Ser 
    290                 295                 300                 


Leu Ile Tyr Gly Gly Thr Asp Val Ala Val Ile Gly Ala Pro Ser Thr 
305                 310                 315                 320 


Thr Asp Lys Phe Leu Arg Leu Asn Phe Gln Gly Pro Arg Gly Thr Val 
                325                 330                 335     


Ser Leu Gly Leu Arg Arg Glu Asn Leu Tyr Val Val Ala Tyr Leu Ala 
            340                 345                 350         


Met Asp Asn Ala Asn Val Asn Arg Ala Tyr Tyr Phe Lys Asn Gln Ile 
        355                 360                 365             


Thr Ser Ala Glu Leu Thr Ala Leu Phe Pro Glu Val Val Val Ala Asn 
    370                 375                 380                 


Gln Lys Gln Leu Glu Tyr Gly Glu Asp Tyr Gln Ala Ile Glu Lys Asn 
385                 390                 395                 400 


Ala Lys Ile Thr Thr Gly Asp Gln Ser Arg Lys Glu Leu Gly Leu Gly 
                405                 410                 415     


Ile Asn Leu Leu Ile Thr Met Ile Asp Gly Val Asn Lys Lys Val Arg 
            420                 425                 430         


Val Val Lys Asp Glu Ala Arg Phe Leu Leu Ile Ala Ile Gln Met Thr 
        435                 440                 445             


Ala Glu Ala Ala Arg Phe Arg Tyr Ile Gln Asn Leu Val Thr Lys Asn 
    450                 455                 460                 


Phe Pro Asn Lys Phe Asp Ser Glu Asn Lys Val Ile Gln Phe Gln Val 
465                 470                 475                 480 


Ser Trp Ser Lys Ile Ser Thr Ala Ile Phe Gly Asp Cys Lys Asn Gly 
                485                 490                 495     


Val Phe Asn Lys Asp Tyr Asp Phe Gly Phe Gly Lys Val Arg Gln Ala 
            500                 505                 510         


Lys Asp Leu Gln Met Gly Leu Leu Lys Tyr Leu Gly Arg Pro Lys Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Arg Trp Cys Cys Pro Gly 
    530                 535                 540                 


Cys Cys Lys Thr Phe Gly Gly Gly Gly Ser His His His His His His 
545                 550                 555                 560 


His His His His His Arg Trp Cys Cys Pro Gly Cys Cys Lys Thr Phe 
                565                 570                 575     


<210>  74
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalent VHHEGFR-Cys

<400>  74

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Val Ala Ile Asn Trp Ser Ser Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn 
225                 230                 235                 240 


Tyr Asn Phe Lys Asp Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser His His His His His His His His His His His 
            260                 265                 270         


Arg Trp Cys Cys Pro Gly Cys Cys Lys Thr Phe 
        275                 280             


<210>  75
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH 7D12

<400>  75

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  76
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH 9G8

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         
