                         SEQUENCE LISTING

<110>  Nanjing Legend Biotech Co., Ltd.
 
<120>  GENETIC ENGINEERING OF æ T CELLS FOR IMMUNOTHERAPY

<130>  P10828-PCT

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR amino acid sequence

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  2
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with soluble IL-18 amino acid 
       sequence

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile 
            500                 505                 510         


Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu 
        515                 520                 525             


Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile 
    530                 535                 540                 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Tyr Phe Gly 
545                 550                 555                 560 


Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp Gln Val 
                565                 570                 575     


Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met Thr Asp 
            580                 585                 590         


Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile Ser Met 
        595                 600                 605             


Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser Val Lys 
    610                 615                 620                 


Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile Ser Phe 
625                 630                 635                 640 


Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser Asp Ile 
                645                 650                 655     


Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met Gln Phe 
            660                 665                 670         


Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys Glu Arg 
        675                 680                 685             


Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly Asp Arg 
    690                 695                 700                 


Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
705                 710                 


<210>  3
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with soluble IL-15 CAR amino acid 
       sequence

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile 
            500                 505                 510         


Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu 
        515                 520                 525             


Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile 
    530                 535                 540                 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val 
545                 550                 555                 560 


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
                565                 570                 575     


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
            580                 585                 590         


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
        595                 600                 605             


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
    610                 615                 620                 


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
625                 630                 635                 640 


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
                645                 650                 655     


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670     


<210>  4
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CD28 CAR armored with soluble IL-15 amino acid sequence

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile Ser 
            500                 505                 510         


Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu 
        515                 520                 525             


Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu 
    530                 535                 540                 


Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn 
545                 550                 555                 560 


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
                565                 570                 575     


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
            580                 585                 590         


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
        595                 600                 605             


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
    610                 615                 620                 


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
625                 630                 635                 640 


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
                645                 650                 655     


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670 


<210>  5
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with membrane-bound IL-18 amino acid 
       sequence

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile 
            500                 505                 510         


Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu 
        515                 520                 525             


Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile 
    530                 535                 540                 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Tyr Phe Gly 
545                 550                 555                 560 


Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp Gln Val 
                565                 570                 575     


Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met Thr Asp 
            580                 585                 590         


Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile Ser Met 
        595                 600                 605             


Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser Val Lys 
    610                 615                 620                 


Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile Ser Phe 
625                 630                 635                 640 


Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser Asp Ile 
                645                 650                 655     


Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met Gln Phe 
            660                 665                 670         


Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys Glu Arg 
        675                 680                 685             


Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly Asp Arg 
    690                 695                 700                 


Ser Ile Met Phe Thr Val Gln Asn Glu Asp Pro Thr Asn Gly Pro Lys 
705                 710                 715                 720 


Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu 
                725                 730                 735     


Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg 
            740                 745             


<210>  6
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 4-1BB CAR amino acid sequence

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  7
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 4-1BB CAR armored with soluble IL-18 amino acid 
       sequence

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile Ser 
            500                 505                 510         


Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu 
        515                 520                 525             


Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu 
    530                 535                 540                 


Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Tyr Phe Gly Lys 
545                 550                 555                 560 


Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp Gln Val Leu 
                565                 570                 575     


Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met Thr Asp Ser 
            580                 585                 590         


Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile Ser Met Tyr 
        595                 600                 605             


Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser Val Lys Cys 
    610                 615                 620                 


Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile Ser Phe Lys 
625                 630                 635                 640 


Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser Asp Ile Ile 
                645                 650                 655     


Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met Gln Phe Glu 
            660                 665                 670         


Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys Glu Arg Asp 
        675                 680                 685             


Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly Asp Arg Ser 
    690                 695                 700                 


Ile Met Phe Thr Val Gln Asn Glu Asp 
705                 710             


<210>  8
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 4-1BB CAR armored with membrane-bound IL-18 amino acid 
       sequence

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile Ser 
            500                 505                 510         


Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu 
        515                 520                 525             


Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu 
    530                 535                 540                 


Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Tyr Phe Gly Lys 
545                 550                 555                 560 


Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp Gln Val Leu 
                565                 570                 575     


Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met Thr Asp Ser 
            580                 585                 590         


Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile Ser Met Tyr 
        595                 600                 605             


Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser Val Lys Cys 
    610                 615                 620                 


Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile Ser Phe Lys 
625                 630                 635                 640 


Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser Asp Ile Ile 
                645                 650                 655     


Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met Gln Phe Glu 
            660                 665                 670         


Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys Glu Arg Asp 
        675                 680                 685             


Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly Asp Arg Ser 
    690                 695                 700                 


Ile Met Phe Thr Val Gln Asn Glu Asp Pro Thr Asn Gly Pro Lys Ile 
705                 710                 715                 720 


Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val 
                725                 730                 735     


Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg 
            740                 745         


<210>  9
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-GPC3 4-1BB CAR amino acid sequence

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Ala Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
        195                 200                 205             


Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser 
    210                 215                 220                 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  10
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-GPC3 4-1BB CAR armored with soluble IL-18 amino acid 
       sequence

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Ala Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
        195                 200                 205             


Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser 
    210                 215                 220                 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile 
            500                 505                 510         


Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu 
        515                 520                 525             


Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile 
    530                 535                 540                 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Tyr Phe Gly 
545                 550                 555                 560 


Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp Gln Val 
                565                 570                 575     


Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met Thr Asp 
            580                 585                 590         


Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile Ser Met 
        595                 600                 605             


Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser Val Lys 
    610                 615                 620                 


Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile Ser Phe 
625                 630                 635                 640 


Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser Asp Ile 
                645                 650                 655     


Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met Gln Phe 
            660                 665                 670         


Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys Glu Arg 
        675                 680                 685             


Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly Asp Arg 
    690                 695                 700                 


Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
705                 710                 


<210>  11
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with 5xNFkb 5xAP-inducible IL-15 
       nucleic acid sequence

<400>  11
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagg atgtattgat gaacatctgc acgatgtgca caaagctctg     1560

caggaactcc ttgatgttct tctcctccag ctcctcacac tccttgcagc cgctctctgt     1620

cacattgccg ttggagctca gagaattgtt ggccaggatg atcagattct ccacggtatc     1680

gtggatagag gcgtcgccag actccaggga gatgacctgc agctccagca gaaaacactt     1740

catggcggtc accttgcagg aagggtgcac atcgctctct gtatacaggg tggcgtcgat     1800

gtgcatagac tggatcagat cctcgatctt cttcaggtcg gagatcacat tcacccagtt     1860

ggcctctgtc ttgggcaggc cggcgctaaa gcagcccagg atgaacacgt ggatgccggc     1920

ctcggtcagg aagtgagagt tcagcagcag acacaggtag cactggatgc tgatagatct     1980

caggtggggc ttggagatcc gcatggctct gtctcaggtc agtatagaag ctttgatgtg     2040

aagtcagcca agaacagctg aacactactt ctgctgaggc ccttttatag gagggattgc     2100

ttcctgtgaa taataggagg atattgtcca catccagtaa agaggaaatc cccaactgca     2160

tccaaaaagt tttctgggaa tatccactgc tgcaggtgac tcactgagtc agtgactcaa     2220

gtggaaagtc cccagtggaa agtccccagt ggaaagtccc cagtggaaag tccccagtgg     2280

aaagtcccc                                                             2289


<210>  12
<211>  2261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with 3xNFkb 3xAP-inducible IL-15 
       nucleic acid sequence

<400>  12
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagg atgtattgat gaacatctgc acgatgtgca caaagctctg     1560

caggaactcc ttgatgttct tctcctccag ctcctcacac tccttgcagc cgctctctgt     1620

cacattgccg ttggagctca gagaattgtt ggccaggatg atcagattct ccacggtatc     1680

gtggatagag gcgtcgccag actccaggga gatgacctgc agctccagca gaaaacactt     1740

catggcggtc accttgcagg aagggtgcac atcgctctct gtatacaggg tggcgtcgat     1800

gtgcatagac tggatcagat cctcgatctt cttcaggtcg gagatcacat tcacccagtt     1860

ggcctctgtc ttgggcaggc cggcgctaaa gcagcccagg atgaacacgt ggatgccggc     1920

ctcggtcagg aagtgagagt tcagcagcag acacaggtag cactggatgc tgatagatct     1980

caggtggggc ttggagatcc gcatggctct gtctcaggtc agtatagaag ctttgatgtg     2040

aagtcagcca agaacagctg aacactactt ctgctgaggc ccttttatag gagggattgc     2100

ttcctgtgaa taataggagg atattgtcca catccagtaa agaggaaatc cccaactgca     2160

tccaaaaagt tttctgggaa tatccactgc tgcaggtgac tcactgagtc agtgactcaa     2220

gtggaaagtc cccagtggaa agtccccagt ggaaagtccc c                         2261


<210>  13
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR nucleic acid sequence

<400>  13
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgccgtgc agctggtgga gagcggcggc ggcctggtgc aggccggcga cagcctgagg      120

ctgacctgca ccgccagcgg cagggccttc agcacctact tcatggcctg gttcaggcag      180

gcccccggca aggagaggga gttcgtggcc ggcatcgcct ggagcggcgg cagcaccgcc      240

tacgccgaca gcgtgaaggg caggttcacc atcagcaggg acaacgccaa gaacaccgtg      300

tacctgcaga tgaacagcct gaagagcgag gacaccgccg tgtactactg cgccagcagg      360

ggcatcgagg tggaggagtt cggcgcctgg ggccagggca cccaggtgac cgtgagcagc      420

ggcggcggcg gcagccaggt gcagctggag gagagcggcg gcggcagcgt gcaggccggc      480

ggcagcctga ggctgagctg cgcctacacc tacagcacct acagcaacta ctacatgggc      540

tggttcaggg aggcccccgg caaggccagg accagcgtgg ccatcatcag cagcgacacc      600

accatcacct acaaggacgc cgtgaagggc aggttcacca tcagcaagga caacgccaag      660

aacaccctgt acctgcagat gaacagcctg aagcccgagg acagcgccat gtacaggtgc      720

gccgcctgga ccagcgactg gagcgtggcc tactggggcc agggcaccca ggtgaccgtg      780

agcagcacca gcaccaccac ccccgccccc aggcccccca cccccgcccc caccatcgcc      840

agccagcccc tgagcctgag gcccgaggcc tgcaggcccg ccgccggcgg cgccgtgcac      900

accaggggcc tggacttcgc ctgcgacatc tacatctggg cccccctggc cggcacctgc      960

ggcgtgctgc tgctgagcct ggtgatcacc ctgtactgca agaggggcag gaagaagctg     1020

ctgtacatct tcaagcagcc cttcatgagg cccgtgcaga ccacccagga ggaggacggc     1080

tgcagctgca ggttccccga ggaggaggag ggcggctgcg agctgagggt gaagttcagc     1140

aggagcgccg acgcccccgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac     1200

ctgggcagga gggaggagta cgacgtgctg gacaagagga ggggcaggga ccccgagatg     1260

ggcggcaagc ccaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc     1380

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac     1440

atgcaggccc tgccccccag g                                               1461


<210>  14
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with soluble IL-18 nucleic acid 
       sequence

<400>  14
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgccgtgc agctggtgga gagcggcggc ggcctggtgc aggccggcga cagcctgagg      120

ctgacctgca ccgccagcgg cagggccttc agcacctact tcatggcctg gttcaggcag      180

gcccccggca aggagaggga gttcgtggcc ggcatcgcct ggagcggcgg cagcaccgcc      240

tacgccgaca gcgtgaaggg caggttcacc atcagcaggg acaacgccaa gaacaccgtg      300

tacctgcaga tgaacagcct gaagagcgag gacaccgccg tgtactactg cgccagcagg      360

ggcatcgagg tggaggagtt cggcgcctgg ggccagggca cccaggtgac cgtgagcagc      420

ggcggcggcg gcagccaggt gcagctggag gagagcggcg gcggcagcgt gcaggccggc      480

ggcagcctga ggctgagctg cgcctacacc tacagcacct acagcaacta ctacatgggc      540

tggttcaggg aggcccccgg caaggccagg accagcgtgg ccatcatcag cagcgacacc      600

accatcacct acaaggacgc cgtgaagggc aggttcacca tcagcaagga caacgccaag      660

aacaccctgt acctgcagat gaacagcctg aagcccgagg acagcgccat gtacaggtgc      720

gccgcctgga ccagcgactg gagcgtggcc tactggggcc agggcaccca ggtgaccgtg      780

agcagcacca gcaccaccac ccccgccccc aggcccccca cccccgcccc caccatcgcc      840

agccagcccc tgagcctgag gcccgaggcc tgcaggcccg ccgccggcgg cgccgtgcac      900

accaggggcc tggacttcgc ctgcgacatc tacatctggg cccccctggc cggcacctgc      960

ggcgtgctgc tgctgagcct ggtgatcacc ctgtactgca agaggggcag gaagaagctg     1020

ctgtacatct tcaagcagcc cttcatgagg cccgtgcaga ccacccagga ggaggacggc     1080

tgcagctgca ggttccccga ggaggaggag ggcggctgcg agctgagggt gaagttcagc     1140

aggagcgccg acgcccccgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac     1200

ctgggcagga gggaggagta cgacgtgctg gacaagagga ggggcaggga ccccgagatg     1260

ggcggcaagc ccaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc     1380

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac     1440

atgcaggccc tgccccccag gggcagcggc gccaccaact tcagcctgct gaagcaggcc     1500

ggcgacgtgg aggagaaccc cggccccatg aggatcagca agccccacct gaggagcatc     1560

agcatccagt gctacctgtg cctgctgctg aacagccact tcctgaccga ggccggcatc     1620

cacgtgttca tcctgggctg cttcagcgcc ggcctgccca agaccgaggc ctacttcggc     1680

aagctggaga gcaagctgag cgtgatcagg aacctgaacg accaggtgct gttcatcgac     1740

cagggcaaca ggcccctgtt cgaggacatg accgacagcg actgcaggga caacgccccc     1800

aggaccatct tcatcatcag catgtacaag gacagccagc ccaggggcat ggccgtgacc     1860

atcagcgtga agtgcgagaa gatcagcacc ctgagctgcg agaacaagat catcagcttc     1920

aaggagatga acccccccga caacatcaag gacaccaaga gcgacatcat cttcttccag     1980

aggagcgtgc ccggccacga caacaagatg cagttcgaga gcagcagcta cgagggctac     2040

ttcctggcct gcgagaagga gagggacctg ttcaagctga tcctgaagaa ggaggacgag     2100

ctgggcgaca ggagcatcat gttcaccgtg cagaacgagg ac                        2142


<210>  15
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with soluble IL-15 CAR nucleic acid 
       sequence

<400>  15
atggcactgc ctgtcacggc ccttctgctc ccgctggctc tgctcctgca cgccgcacgt       60

ccagcggtgc agttggtgga gagcggaggt ggcctcgtgc aggccggcga ttctttgcgg      120

ctgacctgta cagcatcggg ccgtgcgttc tctacctatt tcatggcatg gttccgccag      180

gcgcctggca aagagcgcga gttcgttgct ggcatagcct ggtctggagg cagtaccgct      240

tacgcggaca gcgtgaaggg ccggttcacc atctctcgcg acaacgccaa gaacaccgtg      300

tacctgcaga tgaactccct caagtcggag gacaccgctg tctactactg cgcctccagg      360

ggcatcgagg tagaggagtt cggtgcttgg ggccaaggca cccaggtgac ggtctcctcc      420

ggcggtggag gtagccaggt ccagctggag gagagtggcg gcggctccgt gcaggccggc      480

ggttcgctgc gcctgtcctg tgcctacacc tactccacgt actcaaacta ctacatgggc      540

tggttccggg aggccccagg caaggcccgc acctccgtgg ccatcatcag ctccgacacc      600

accatcactt acaaggacgc cgtgaaaggt cgtttcacca tctccaagga caacgcgaag      660

aacaccctgt acctgcagat gaattccctg aagcccgaag actcggctat gtataggtgt      720

gctgcttgga ccagcgattg gtctgtggct tattggggcc agggcaccca ggtcacagtg      780

agctctacat caactacaac ccccgccccg cgccccccaa ccccggctcc gactatcgct      840

tcccagccat tgtctctccg ccctgaagct tgtagacctg cagccggcgg cgccgtccat      900

actcgcggtt tggacttcgc ctgcgacatc tatatctggg cgcccctggc cggtacctgc      960

ggggtgctgc tgctgagtct ggtcatcacc ctttactgta agcgtggccg caagaagctg     1020

ttgtacatct tcaagcagcc cttcatgcgt ccggtgcaga cgacccagga ggaagacgga     1080

tgctcttgcc gattccctga ggaagaggag ggcgggtgtg aactcagagt aaaatttagc     1140

cgctcggctg acgcacccgc ctaccagcag ggacagaacc agctgtacaa cgagctcaac     1200

ctgggccgcc gcgaagagta cgatgttttg gataaacgcc gcggtcgaga cccggagatg     1260

ggaggtaagc ccaggcgcaa aaaccctcag gagggcctgt acaacgagct acagaaagac     1320

aagatggccg aggcgtattc cgagatcggt atgaagggcg agcggcgcag agggaaaggc     1380

cacgacggcc tttatcaggg cctctccact gccaccaagg atacttacga cgcacttcac     1440

atgcaggccc tgcccccgcg tgggagcggg gctaccaact ttagcctgct gaagcaggcg     1500

ggagatgtgg aggagaatcc agggcccatg cgcatctcta aacctcattt gcgctcgatc     1560

tcgattcagt gctacctgtg cctgctactc aactcccact ttctgaccga agcaggcatc     1620

catgttttca tcttagggtg ctttagcgcc gggctaccca agactgaggc caactgggtc     1680

aacgtgattt ccgaccttaa gaagattgag gacctgatcc agtcgatgca cattgacgcc     1740

actctgtaca cggagtccga tgtgcacccc agctgtaagg tgacggctat gaagtgcttt     1800

ctgctggaat tgcaggtgat ttccctggag tctggagacg cgtcaatcca cgacacggta     1860

gagaacctga tcatcctggc gaacaactcc ctctcgagca atggcaacgt gactgagagc     1920

gggtgtaagg agtgcgagga gctcgaggag aagaatatca aggagttcct gcaatccttc     1980

gtccacatcg tgcagatgtt tattaatact agc                                  2013


<210>  16
<211>  2010
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA CD28 CAR armored with soluble IL-15 nucleic acid 
       sequence

<400>  16
atggctttgc cggtgaccgc tctgctgctg cccctggctt tgctgcttca cgccgctcgc       60

cctgccgtgc aactcgtgga atctggcggc ggactggtcc aggcgggtga ttctctccgg      120

ttgacatgca ctgcttccgg gagggcgttc tccacctatt tcatggcgtg gttccgccag      180

gcgccgggca aggaacgcga gttcgtggcg ggcatcgcgt ggtctggggg ttcgactgcc      240

tacgcggaca gtgtcaaggg acggttcacc atcagccgcg acaacgcgaa gaacacggta      300

tacctgcaga tgaatagcct gaaatccgaa gatactgcag tgtattactg tgcctcccgc      360

ggtatcgagg tggaggagtt cggcgcctgg ggccagggca cccaggtcac cgtgtcgtcc      420

ggcggcggtg gctcccaagt gcagttggaa gagagcggcg ggggctccgt acaggctggg      480

ggctcccttc gcctgagctg cgcctacacc tactctacct acagcaacta ctacatgggt      540

tggttcagag aggctcccgg gaaggcgcgc acttccgtgg ccatcatctc ttccgacacg      600

actatcacct acaaggacgc tgtgaaggga agattcacga tctcaaaaga caatgccaag      660

aacactctct acctccagat gaactccctg aagcctgaag acagcgcaat gtataggtgt      720

gccgcttgga cgagcgattg gtctgtcgca tattggggcc aggggaccca ggtgacagtg      780

tcctcgacga gcaccaccac acctgctcct aggcccccaa ctccggcgcc caccattgct      840

tcacagccac tgtctctgcg cccggaggcc tgccgaccgg ccgctggagg cgctgtgcat      900

acacgtggtt tggatttcgc ctgtgacatc tacatctggg cccccctggc cgggacctgc      960

ggggtgctgc tgctttcgct ggtgatcacc ctatactgtc gctccaagcg cagtcgccta     1020

cttcacagtg attacatgaa catgactccc cgccgtcccg gccctacccg caagcactac     1080

cagccctatg cccccccgcg tgacttcgct gcttaccgga gccgcgtcaa attttcacgc     1140

agtgcggacg cgcctgccta tcagcaggga cagaaccagc tttacaacga gctcaacctg     1200

ggccggcgcg aggagtacga cgtgctggac aagcgccgtg gacgtgatcc ggagatgggc     1260

ggaaaacctc ggcgcaaaaa tcctcaggag ggcctttaca acgagcttca gaaggacaaa     1320

atggccgagg cttactcgga gatcggtatg aagggcgagc gccgtcgcgg caaagggcac     1380

gacggcctgt accagggatt atcgactgct accaaggata catacgacgc gctccacatg     1440

caggccctgc ctccccgtgg ctccggtgca accaacttct ccctcctcaa gcaggccggt     1500

gacgtggagg agaatccagg ccccatgcgc atctccaagc cgcacctgag gtccatttcc     1560

atacaatgtt acctgtgcct gttgctcaac agccactttc tgaccgaggc cggcatccac     1620

gtgttcatcc tgggttgctt ttcggccggc ctgccgaaga ccgaggctaa ctgggttaac     1680

gtgatctctg atctaaagaa gattgaggac ctgatccagt ccatgcatat tgacgccacc     1740

ctgtacacgg agagtgacgt gcacccctct tgtaaggtga ccgccatgaa gtgctttctg     1800

ctggagctgc aggtcatcag cttggagtct ggggacgcat ccattcatga caccgtggag     1860

aacctgatta tcctggccaa caactctctg tcctcaaatg gcaacgtcac cgagagcggc     1920

tgtaaggaat gcgaggagct ggaggagaag aacatcaagg agttcctgca gtccttcgtc     1980

cacatcgtcc agatgtttat taacacgtct                                      2010


<210>  17
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-BCMA 4-1BB CAR armored with membrane-bound IL-18 nucleic 
       acid sequence

<400>  17
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgccgtgc agctggtgga gagcggcggc ggcctggtgc aggccggcga cagcctgagg      120

ctgacctgca ccgccagcgg cagggccttc agcacctact tcatggcctg gttcaggcag      180

gcccccggca aggagaggga gttcgtggcc ggcatcgcct ggagcggcgg cagcaccgcc      240

tacgccgaca gcgtgaaggg caggttcacc atcagcaggg acaacgccaa gaacaccgtg      300

tacctgcaga tgaacagcct gaagagcgag gacaccgccg tgtactactg cgccagcagg      360

ggcatcgagg tggaggagtt cggcgcctgg ggccagggca cccaggtgac cgtgagcagc      420

ggcggcggcg gcagccaggt gcagctggag gagagcggcg gcggcagcgt gcaggccggc      480

ggcagcctga ggctgagctg cgcctacacc tacagcacct acagcaacta ctacatgggc      540

tggttcaggg aggcccccgg caaggccagg accagcgtgg ccatcatcag cagcgacacc      600

accatcacct acaaggacgc cgtgaagggc aggttcacca tcagcaagga caacgccaag      660

aacaccctgt acctgcagat gaacagcctg aagcccgagg acagcgccat gtacaggtgc      720

gccgcctgga ccagcgactg gagcgtggcc tactggggcc agggcaccca ggtgaccgtg      780

agcagcacca gcaccaccac ccccgccccc aggcccccca cccccgcccc caccatcgcc      840

agccagcccc tgagcctgag gcccgaggcc tgcaggcccg ccgccggcgg cgccgtgcac      900

accaggggcc tggacttcgc ctgcgacatc tacatctggg cccccctggc cggcacctgc      960

ggcgtgctgc tgctgagcct ggtgatcacc ctgtactgca agaggggcag gaagaagctg     1020

ctgtacatct tcaagcagcc cttcatgagg cccgtgcaga ccacccagga ggaggacggc     1080

tgcagctgca ggttccccga ggaggaggag ggcggctgcg agctgagggt gaagttcagc     1140

aggagcgccg acgcccccgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac     1200

ctgggcagga gggaggagta cgacgtgctg gacaagagga ggggcaggga ccccgagatg     1260

ggcggcaagc ccaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc     1380

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac     1440

atgcaggccc tgccccccag gggcagcggc gccaccaact tcagcctgct gaagcaggcc     1500

ggcgacgtgg aggagaaccc cggccccatg aggatcagca agccccacct gaggagcatc     1560

agcatccagt gctacctgtg cctgctgctg aacagccact tcctgaccga ggccggcatc     1620

cacgtgttca tcctgggctg cttcagcgcc ggcctgccca agaccgaggc ctacttcggc     1680

aagctggaga gcaagctgag cgtgatcagg aacctgaacg accaggtgct gttcatcgac     1740

cagggcaaca ggcccctgtt cgaggacatg accgacagcg actgcaggga caacgccccc     1800

aggaccatct tcatcatcag catgtacaag gacagccagc ccaggggcat ggccgtgacc     1860

atcagcgtga agtgcgagaa gatcagcacc ctgagctgcg agaacaagat catcagcttc     1920

aaggagatga acccccccga caacatcaag gacaccaaga gcgacatcat cttcttccag     1980

aggagcgtgc ccggccacga caacaagatg cagttcgaga gcagcagcta cgagggctac     2040

ttcctggcct gcgagaagga gagggacctg ttcaagctga tcctgaagaa ggaggacgag     2100

ctgggcgaca ggagcatcat gttcaccgtg cagaacgagg accccaccaa cggccccaag     2160

atccccagca tcgccaccgg catggtgggc gccctgctgc tgctgctggt ggtggccctg     2220

ggcatcggcc tgttcatgag gagg                                            2244


<210>  18
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 4-1BB CAR nucleic acid sequence

<400>  18
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg      120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag      180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc      240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag      300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc      360

ggcggcacca agctggagat caccggcggc ggcggcagcg gcggcggcgg cagcggcggc      420

ggcggcagcg aggtgaagct gcaggagagc ggccccggcc tggtggcccc cagccagagc      480

ctgagcgtga cctgcaccgt gagcggcgtg agcctgcccg actacggcgt gagctggatc      540

aggcagcccc ccaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagaccacc      600

tactacaaca gcgccctgaa gagcaggctg accatcatca aggacaacag caagagccag      660

gtgttcctga agatgaacag cctgcagacc gacgacaccg ccatctacta ctgcgccaag      720

cactactact acggcggcag ctacgccatg gactactggg gccagggcac cagcgtgacc      780

gtgagcagca ccaccacccc cgcccccagg ccccccaccc ccgcccccac catcgccagc      840

cagcccctga gcctgaggcc cgaggcctgc aggcccgccg ccggcggcgc cgtgcacacc      900

aggggcctgg acttcgcctg cgacatctac atctgggccc ccctggccgg cacctgcggc      960

gtgctgctgc tgagcctggt gatcaccctg tactgcaaga ggggcaggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacca cccaggagga ggacggctgc     1080

agctgcaggt tccccgagga ggaggagggc ggctgcgagc tgagggtgaa gttcagcagg     1140

agcgccgacg cccccgccta caagcagggc cagaaccagc tgtacaacga gctgaacctg     1200

ggcaggaggg aggagtacga cgtgctggac aagaggaggg gcagggaccc cgagatgggc     1260

ggcaagccca ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag     1320

atggccgagg cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac     1380

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     1440

caggccctgc cccccagg                                                   1458


<210>  19
<211>  2139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 4-1BB CAR armored with soluble IL-18 nucleic acid 
       sequence

<400>  19
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg      120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag      180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc      240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag      300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc      360

ggcggcacca agctggagat caccggcggc ggcggcagcg gcggcggcgg cagcggcggc      420

ggcggcagcg aggtgaagct gcaggagagc ggccccggcc tggtggcccc cagccagagc      480

ctgagcgtga cctgcaccgt gagcggcgtg agcctgcccg actacggcgt gagctggatc      540

aggcagcccc ccaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagaccacc      600

tactacaaca gcgccctgaa gagcaggctg accatcatca aggacaacag caagagccag      660

gtgttcctga agatgaacag cctgcagacc gacgacaccg ccatctacta ctgcgccaag      720

cactactact acggcggcag ctacgccatg gactactggg gccagggcac cagcgtgacc      780

gtgagcagca ccaccacccc cgcccccagg ccccccaccc ccgcccccac catcgccagc      840

cagcccctga gcctgaggcc cgaggcctgc aggcccgccg ccggcggcgc cgtgcacacc      900

aggggcctgg acttcgcctg cgacatctac atctgggccc ccctggccgg cacctgcggc      960

gtgctgctgc tgagcctggt gatcaccctg tactgcaaga ggggcaggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacca cccaggagga ggacggctgc     1080

agctgcaggt tccccgagga ggaggagggc ggctgcgagc tgagggtgaa gttcagcagg     1140

agcgccgacg cccccgccta caagcagggc cagaaccagc tgtacaacga gctgaacctg     1200

ggcaggaggg aggagtacga cgtgctggac aagaggaggg gcagggaccc cgagatgggc     1260

ggcaagccca ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag     1320

atggccgagg cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac     1380

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     1440

caggccctgc cccccagggg cagcggcgcc accaacttca gcctgctgaa gcaggccggc     1500

gacgtggagg agaaccccgg ccccatgagg atcagcaagc cccacctgag gagcatcagc     1560

atccagtgct acctgtgcct gctgctgaac agccacttcc tgaccgaggc cggcatccac     1620

gtgttcatcc tgggctgctt cagcgccggc ctgcccaaga ccgaggccta cttcggcaag     1680

ctggagagca agctgagcgt gatcaggaac ctgaacgacc aggtgctgtt catcgaccag     1740

ggcaacaggc ccctgttcga ggacatgacc gacagcgact gcagggacaa cgcccccagg     1800

accatcttca tcatcagcat gtacaaggac agccagccca ggggcatggc cgtgaccatc     1860

agcgtgaagt gcgagaagat cagcaccctg agctgcgaga acaagatcat cagcttcaag     1920

gagatgaacc cccccgacaa catcaaggac accaagagcg acatcatctt cttccagagg     1980

agcgtgcccg gccacgacaa caagatgcag ttcgagagca gcagctacga gggctacttc     2040

ctggcctgcg agaaggagag ggacctgttc aagctgatcc tgaagaagga ggacgagctg     2100

ggcgacagga gcatcatgtt caccgtgcag aacgaggac                            2139


<210>  20
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 4-1BB CAR armored with membrane-bound IL-18 nucleic 
       acid sequence

<400>  20
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgacagggtg      120

accatcagct gcagggccag ccaggacatc agcaagtacc tgaactggta ccagcagaag      180

cccgacggca ccgtgaagct gctgatctac cacaccagca ggctgcacag cggcgtgccc      240

agcaggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag      300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcggc      360

ggcggcacca agctggagat caccggcggc ggcggcagcg gcggcggcgg cagcggcggc      420

ggcggcagcg aggtgaagct gcaggagagc ggccccggcc tggtggcccc cagccagagc      480

ctgagcgtga cctgcaccgt gagcggcgtg agcctgcccg actacggcgt gagctggatc      540

aggcagcccc ccaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagaccacc      600

tactacaaca gcgccctgaa gagcaggctg accatcatca aggacaacag caagagccag      660

gtgttcctga agatgaacag cctgcagacc gacgacaccg ccatctacta ctgcgccaag      720

cactactact acggcggcag ctacgccatg gactactggg gccagggcac cagcgtgacc      780

gtgagcagca ccaccacccc cgcccccagg ccccccaccc ccgcccccac catcgccagc      840

cagcccctga gcctgaggcc cgaggcctgc aggcccgccg ccggcggcgc cgtgcacacc      900

aggggcctgg acttcgcctg cgacatctac atctgggccc ccctggccgg cacctgcggc      960

gtgctgctgc tgagcctggt gatcaccctg tactgcaaga ggggcaggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacca cccaggagga ggacggctgc     1080

agctgcaggt tccccgagga ggaggagggc ggctgcgagc tgagggtgaa gttcagcagg     1140

agcgccgacg cccccgccta caagcagggc cagaaccagc tgtacaacga gctgaacctg     1200

ggcaggaggg aggagtacga cgtgctggac aagaggaggg gcagggaccc cgagatgggc     1260

ggcaagccca ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag     1320

atggccgagg cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac     1380

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     1440

caggccctgc cccccagggg cagcggcgcc accaacttca gcctgctgaa gcaggccggc     1500

gacgtggagg agaaccccgg ccccatgagg atcagcaagc cccacctgag gagcatcagc     1560

atccagtgct acctgtgcct gctgctgaac agccacttcc tgaccgaggc cggcatccac     1620

gtgttcatcc tgggctgctt cagcgccggc ctgcccaaga ccgaggccta cttcggcaag     1680

ctggagagca agctgagcgt gatcaggaac ctgaacgacc aggtgctgtt catcgaccag     1740

ggcaacaggc ccctgttcga ggacatgacc gacagcgact gcagggacaa cgcccccagg     1800

accatcttca tcatcagcat gtacaaggac agccagccca ggggcatggc cgtgaccatc     1860

agcgtgaagt gcgagaagat cagcaccctg agctgcgaga acaagatcat cagcttcaag     1920

gagatgaacc cccccgacaa catcaaggac accaagagcg acatcatctt cttccagagg     1980

agcgtgcccg gccacgacaa caagatgcag ttcgagagca gcagctacga gggctacttc     2040

ctggcctgcg agaaggagag ggacctgttc aagctgatcc tgaagaagga ggacgagctg     2100

ggcgacagga gcatcatgtt caccgtgcag aacgaggacc ccaccaacgg ccccaagatc     2160

cccagcatcg ccaccggcat ggtgggcgcc ctgctgctgc tgctggtggt ggccctgggc     2220

atcggcctgt tcatgaggag g                                               2241


<210>  21
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-GPC3 4-1BB CAR nucleic acid sequence

<400>  21
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacgtgg tgatgaccca gagccccctg agcctgcccg tgacccccgg cgagcccgcc      120

agcatcagct gcaggagcag ccagagcctg gtgcacagca acgccaacac ctacctgcac      180

tggtacctgc agaagcccgg ccagagcccc cagctgctga tctacaaggt gagcaacagg      240

ttcagcggcg tgcccgacag gttcagcggc agcggcagcg gcaccgactt caccctgaag      300

atcagcaggg tggaggccga ggacgtgggc gtgtactact gcagccagaa cacccacgtg      360

ccccccacct tcggccaggg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagccag gtgcagctgg tgcagagcgg cgccgaggtg      480

aagaagcccg gcgccagcgt gaaggtgagc tgcaaggcca gcggctacac cttcaccgac      540

tacgagatgc actgggtgag gcaggccccc ggccagggcc tggagtggat gggcgccctg      600

gaccccaaga ccggcgacac cgcctacagc cagaagttca agggcagggt gaccctgacc      660

gccgacgaga gcaccagcac cgcctacatg gagctgagca gcctgaggag cgaggacacc      720

gccgtgtact actgcaccag gttctacagc tacacctact ggggccaggg caccctggtg      780

accgtgagca gcaccaccac ccccgccccc aggcccccca cccccgcccc caccatcgcc      840

agccagcccc tgagcctgag gcccgaggcc tgcaggcccg ccgccggcgg cgccgtgcac      900

accaggggcc tggacttcgc ctgcgacatc tacatctggg cccccctggc cggcacctgc      960

ggcgtgctgc tgctgagcct ggtgatcacc ctgtactgca agaggggcag gaagaagctg     1020

ctgtacatct tcaagcagcc cttcatgagg cccgtgcaga ccacccagga ggaggacggc     1080

tgcagctgca ggttccccga ggaggaggag ggcggctgcg agctgagggt gaagttcagc     1140

aggagcgccg acgcccccgc ctacaagcag ggccagaacc agctgtacaa cgagctgaac     1200

ctgggcagga gggaggagta cgacgtgctg gacaagagga ggggcaggga ccccgagatg     1260

ggcggcaagc ccaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc     1380

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac     1440

atgcaggccc tgccccccag g                                               1461


<210>  22
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-GPC3 4-1BB CAR armored with soluble IL-18 nucleic acid 
       sequence

<400>  22
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccagg       60

cccgacgtgg tgatgaccca gagccccctg agcctgcccg tgacccccgg cgagcccgcc      120

agcatcagct gcaggagcag ccagagcctg gtgcacagca acgccaacac ctacctgcac      180

tggtacctgc agaagcccgg ccagagcccc cagctgctga tctacaaggt gagcaacagg      240

ttcagcggcg tgcccgacag gttcagcggc agcggcagcg gcaccgactt caccctgaag      300

atcagcaggg tggaggccga ggacgtgggc gtgtactact gcagccagaa cacccacgtg      360

ccccccacct tcggccaggg caccaagctg gagatcaaga ggggcggcgg cggcagcggc      420

ggcggcggca gcggcggcgg cggcagccag gtgcagctgg tgcagagcgg cgccgaggtg      480

aagaagcccg gcgccagcgt gaaggtgagc tgcaaggcca gcggctacac cttcaccgac      540

tacgagatgc actgggtgag gcaggccccc ggccagggcc tggagtggat gggcgccctg      600

gaccccaaga ccggcgacac cgcctacagc cagaagttca agggcagggt gaccctgacc      660

gccgacgaga gcaccagcac cgcctacatg gagctgagca gcctgaggag cgaggacacc      720

gccgtgtact actgcaccag gttctacagc tacacctact ggggccaggg caccctggtg      780

accgtgagca gcaccaccac ccccgccccc aggcccccca cccccgcccc caccatcgcc      840

agccagcccc tgagcctgag gcccgaggcc tgcaggcccg ccgccggcgg cgccgtgcac      900

accaggggcc tggacttcgc ctgcgacatc tacatctggg cccccctggc cggcacctgc      960

ggcgtgctgc tgctgagcct ggtgatcacc ctgtactgca agaggggcag gaagaagctg     1020

ctgtacatct tcaagcagcc cttcatgagg cccgtgcaga ccacccagga ggaggacggc     1080

tgcagctgca ggttccccga ggaggaggag ggcggctgcg agctgagggt gaagttcagc     1140

aggagcgccg acgcccccgc ctacaagcag ggccagaacc agctgtacaa cgagctgaac     1200

ctgggcagga gggaggagta cgacgtgctg gacaagagga ggggcaggga ccccgagatg     1260

ggcggcaagc ccaggaggaa gaacccccag gagggcctgt acaacgagct gcagaaggac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc     1380

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac     1440

atgcaggccc tgccccccag gggcagcggc gccaccaact tcagcctgct gaagcaggcc     1500

ggcgacgtgg aggagaaccc cggccccatg aggatcagca agccccacct gaggagcatc     1560

agcatccagt gctacctgtg cctgctgctg aacagccact tcctgaccga ggccggcatc     1620

cacgtgttca tcctgggctg cttcagcgcc ggcctgccca agaccgaggc ctacttcggc     1680

aagctggaga gcaagctgag cgtgatcagg aacctgaacg accaggtgct gttcatcgac     1740

cagggcaaca ggcccctgtt cgaggacatg accgacagcg actgcaggga caacgccccc     1800

aggaccatct tcatcatcag catgtacaag gacagccagc ccaggggcat ggccgtgacc     1860

atcagcgtga agtgcgagaa gatcagcacc ctgagctgcg agaacaagat catcagcttc     1920

aaggagatga acccccccga caacatcaag gacaccaaga gcgacatcat cttcttccag     1980

aggagcgtgc ccggccacga caacaagatg cagttcgaga gcagcagcta cgagggctac     2040

ttcctggcct gcgagaagga gagggacctg ttcaagctga tcctgaagaa ggaggacgag     2100

ctgggcgaca ggagcatcat gttcaccgtg cagaacgagg ac                        2142


