                         б

<110>  ϴѧҽҩ＼о޹˾
 
<120>  һϸʽṹ׵Ʊ

<130>  IP200733

<150>  CN202010594000.4
<151>  2020-06-24

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  240
<212>  PRT
<213>  human

<400>  1

Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser Gly Val 
1               5                   10                  15      


Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly Pro Gln 
            20                  25                  30          


Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg Thr Thr 
        35                  40                  45              


Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly Pro Pro 
    50                  55                  60                  


Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr Leu His 
65                  70                  75                  80  


Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly Pro Lys 
                85                  90                  95      


Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe Cys Ala 
            100                 105                 110         


Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro Gly Pro 
        115                 120                 125             


Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly Ala Arg 
    130                 135                 140                 


Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala Pro Gly 
145                 150                 155                 160 


Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys Gly Glu 
                165                 170                 175     


Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly Asp Ser 
            180                 185                 190         


Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys Asp Gly 
        195                 200                 205             


Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly Gly Gln 
    210                 215                 220                 


Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly 
225                 230                 235                 240 


<210>  2
<211>  119
<212>  PRT
<213>  human

<400>  2

Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met Met Ser Cys 
1               5                   10                  15      


Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp Pro His Glu 
            20                  25                  30          


Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly Glu Gln Trp 
        35                  40                  45              


Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly 
    50                  55                  60                  


Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Gly Glu Pro 
65                  70                  75                  80  


Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr Ser Gln Arg 
                85                  90                  95      


Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile Glu Cys Phe 
            100                 105                 110         


Met Pro Leu Asp Val Gln Ala 
        115                 


<210>  3
<211>  210
<212>  PRT
<213>  human

<400>  3

Ala Val Gly Val Trp Val Gly Asn Lys Gln Leu Gly His Leu Pro Arg 
1               5                   10                  15      


Asp Glu Ala Ala Arg Tyr Val Pro Val Leu Ala Ser Leu Thr Ala Gln 
            20                  25                  30          


Gly Trp Leu Pro Gln Val Ser Ala Arg Val Trp Gly Thr Glu Trp Ser 
        35                  40                  45              


Asp Tyr Glu Glu Arg Arg Ala Ser Phe Arg Gly Ser Val Arg Leu Asp 
    50                  55                  60                  


Leu Ala Glu Pro His Met Leu Val Pro Val Asn Leu Pro Pro Ser Gly 
65                  70                  75                  80  


Gln His Arg Leu Leu Pro Thr Gly Ala Ala Ile Gln Val Thr Gly Glu 
                85                  90                  95      


Glu Lys His Leu Asp Ala Leu Ala Pro Leu Leu Arg Pro Glu Gly Glu 
            100                 105                 110         


Cys Trp Ala Tyr Val Ser Leu His Glu Met Val Glu Gln Thr Ala Arg 
        115                 120                 125             


Thr Ser Arg Thr Val Val Glu Val Arg Val Asp Gly Ser Arg Val Gly 
    130                 135                 140                 


Gln Leu Thr Pro Lys Met Ser Gly Glu Leu Leu Pro Ala Ile Arg His 
145                 150                 155                 160 


Leu Ala Gln Gly Asp Val Thr Thr Thr Ala Arg Ala Ile Ile Lys Gly 
                165                 170                 175     


Asn Arg Ile Lys Ser Glu Val Val Leu Tyr Val Ala Arg Ala His Glu 
            180                 185                 190         


Leu Pro Asp Thr Trp Leu Gly Pro Ala Ala Pro Ala Ala Pro Ala Gln 
        195                 200                 205             


Met Gln 
    210 


<210>  4
<211>  102
<212>  PRT
<213>  human

<400>  4

Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu Trp Cys 
1               5                   10                  15      


Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe Cys Thr 
            20                  25                  30          


Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn Gly Ala 
        35                  40                  45              


Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr Asp Cys 
    50                  55                  60                  


Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr Thr Gln 
65                  70                  75                  80  


Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala Ala His 
                85                  90                  95      


Glu Glu Ile Cys Thr Thr 
            100         


<210>  5
<211>  90
<212>  PRT
<213>  human

<400>  5

Leu Gly Phe Gly Ser Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys 
1               5                   10                  15      


His Asp Asn Gly Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln 
            20                  25                  30          


Gly Glu Asn Gly Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys 
        35                  40                  45              


Gly Glu Phe Lys Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly 
    50                  55                  60                  


Lys Thr Tyr His Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala 
65                  70                  75                  80  


Ile Cys Ser Cys Thr Cys Phe Gly Gly Gln 
                85                  90  


<210>  6
<211>  119
<212>  PRT
<213>  human

<400>  6

Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met Met Ser Cys 
1               5                   10                  15      


Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp Pro His Glu 
            20                  25                  30          


Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly Glu Gln Trp 
        35                  40                  45              


Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly 
    50                  55                  60                  


Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Gly Glu Pro 
65                  70                  75                  80  


Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr Ser Gln Arg 
                85                  90                  95      


Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile Glu Cys Phe 
            100                 105                 110         


Met Pro Leu Asp Val Gln Ala 
        115                 


<210>  7
<211>  396
<212>  PRT
<213>  human

<400>  7

Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser Gly Val 
1               5                   10                  15      


Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly Pro Gln 
            20                  25                  30          


Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg Thr Thr 
        35                  40                  45              


Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly Pro Pro 
    50                  55                  60                  


Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr Leu His 
65                  70                  75                  80  


Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly Pro Lys 
                85                  90                  95      


Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe Cys Ala 
            100                 105                 110         


Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro Gly Pro 
        115                 120                 125             


Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly Ala Arg 
    130                 135                 140                 


Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala Pro Gly 
145                 150                 155                 160 


Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys Gly Glu 
                165                 170                 175     


Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly Asp Ser 
            180                 185                 190         


Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys Asp Gly 
        195                 200                 205             


Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly Gly Gln 
    210                 215                 220                 


Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly 
225                 230                 235                 240 


Gly Gly Thr Thr Cys Thr Gly Ala Ala Gly Gly Thr Thr Cys Thr Gly 
                245                 250                 255     


Ala Ala Gly Gly Thr Gly Ala Ala Gly Gly Thr Gly Gly Thr Thr Cys 
            260                 265                 270         


Thr Gly Ala Ala Gly Gly Thr Thr Cys Thr Gly Ala Ala Gly Gly Thr 
        275                 280                 285             


Gly Ala Ala Gly Gly Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln 
    290                 295                 300                 


Asp Gly His Leu Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln 
305                 310                 315                 320 


Lys Tyr Ser Phe Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly 
                325                 330                 335     


Gly Asn Ser Asn Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn 
            340                 345                 350         


His Asn Tyr Thr Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys 
        355                 360                 365             


Trp Cys Gly Thr Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe 
    370                 375                 380                 


Cys Pro Met Ala Ala His Glu Glu Ile Cys Thr Thr 
385                 390                 395     


<210>  8
<211>  378
<212>  PRT
<213>  human

<400>  8

His His His His His His Ala Val Gly Val Trp Val Gly Asn Lys Gln 
1               5                   10                  15      


Leu Gly His Leu Pro Arg Asp Glu Ala Ala Arg Tyr Val Pro Val Leu 
            20                  25                  30          


Ala Ser Leu Thr Ala Gln Gly Trp Leu Pro Gln Val Ser Ala Arg Val 
        35                  40                  45              


Trp Gly Thr Glu Trp Ser Asp Tyr Glu Glu Arg Arg Ala Ser Phe Arg 
    50                  55                  60                  


Gly Ser Val Arg Leu Asp Leu Ala Glu Pro His Met Leu Val Pro Val 
65                  70                  75                  80  


Asn Leu Pro Pro Ser Gly Gln His Arg Leu Leu Pro Thr Gly Ala Ala 
                85                  90                  95      


Ile Gln Val Thr Gly Glu Glu Lys His Leu Asp Ala Leu Ala Pro Leu 
            100                 105                 110         


Leu Arg Pro Glu Gly Glu Cys Trp Ala Tyr Val Ser Leu His Glu Met 
        115                 120                 125             


Val Glu Gln Thr Ala Arg Thr Ser Arg Thr Val Val Glu Val Arg Val 
    130                 135                 140                 


Asp Gly Ser Arg Val Gly Gln Leu Thr Pro Lys Met Ser Gly Glu Leu 
145                 150                 155                 160 


Leu Pro Ala Ile Arg His Leu Ala Gln Gly Asp Val Thr Thr Thr Ala 
                165                 170                 175     


Arg Ala Ile Ile Lys Gly Asn Arg Ile Lys Ser Glu Val Val Leu Tyr 
            180                 185                 190         


Val Ala Arg Ala His Glu Leu Pro Asp Thr Trp Leu Gly Pro Ala Ala 
        195                 200                 205             


Pro Ala Ala Pro Ala Gln Met Gln Gly Gly Thr Thr Cys Thr Gly Ala 
    210                 215                 220                 


Ala Gly Gly Thr Thr Cys Thr Gly Ala Ala Gly Gly Thr Gly Ala Ala 
225                 230                 235                 240 


Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Ala Ala Gly Gly Thr Thr 
                245                 250                 255     


Cys Thr Gly Ala Ala Gly Gly Thr Gly Ala Ala Gly Gly Thr Phe Tyr 
            260                 265                 270         


Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu Trp Cys Ser Thr 
        275                 280                 285             


Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe Cys Thr Asp His 
    290                 295                 300                 


Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn Gly Ala Leu Cys 
305                 310                 315                 320 


His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr Asp Cys Thr Ser 
                325                 330                 335     


Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr Thr Gln Asn Tyr 
            340                 345                 350         


Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala Ala His Glu Glu 
        355                 360                 365             


Ile Cys Thr Thr His His His His His His 
    370                 375             


<210>  9
<211>  366
<212>  PRT
<213>  human

<400>  9

His His His His His His Ala Val Gly Val Trp Val Gly Asn Lys Gln 
1               5                   10                  15      


Leu Gly His Leu Pro Arg Asp Glu Ala Ala Arg Tyr Val Pro Val Leu 
            20                  25                  30          


Ala Ser Leu Thr Ala Gln Gly Trp Leu Pro Gln Val Ser Ala Arg Val 
        35                  40                  45              


Trp Gly Thr Glu Trp Ser Asp Tyr Glu Glu Arg Arg Ala Ser Phe Arg 
    50                  55                  60                  


Gly Ser Val Arg Leu Asp Leu Ala Glu Pro His Met Leu Val Pro Val 
65                  70                  75                  80  


Asn Leu Pro Pro Ser Gly Gln His Arg Leu Leu Pro Thr Gly Ala Ala 
                85                  90                  95      


Ile Gln Val Thr Gly Glu Glu Lys His Leu Asp Ala Leu Ala Pro Leu 
            100                 105                 110         


Leu Arg Pro Glu Gly Glu Cys Trp Ala Tyr Val Ser Leu His Glu Met 
        115                 120                 125             


Val Glu Gln Thr Ala Arg Thr Ser Arg Thr Val Val Glu Val Arg Val 
    130                 135                 140                 


Asp Gly Ser Arg Val Gly Gln Leu Thr Pro Lys Met Ser Gly Glu Leu 
145                 150                 155                 160 


Leu Pro Ala Ile Arg His Leu Ala Gln Gly Asp Val Thr Thr Thr Ala 
                165                 170                 175     


Arg Ala Ile Ile Lys Gly Asn Arg Ile Lys Ser Glu Val Val Leu Tyr 
            180                 185                 190         


Val Ala Arg Ala His Glu Leu Pro Asp Thr Trp Leu Gly Pro Ala Ala 
        195                 200                 205             


Pro Ala Ala Pro Ala Gln Met Gln Gly Gly Thr Thr Cys Thr Gly Ala 
    210                 215                 220                 


Ala Gly Gly Thr Thr Cys Thr Gly Ala Ala Gly Gly Thr Gly Ala Ala 
225                 230                 235                 240 


Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Ala Ala Gly Gly Thr Thr 
                245                 250                 255     


Cys Thr Gly Ala Ala Gly Gly Thr Gly Ala Ala Gly Gly Thr Leu Gly 
            260                 265                 270         


Phe Gly Ser Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp 
        275                 280                 285             


Asn Gly Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu 
    290                 295                 300                 


Asn Gly Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu 
305                 310                 315                 320 


Phe Lys Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr 
                325                 330                 335     


Tyr His Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys 
            340                 345                 350         


Ser Cys Thr Cys Phe Gly Gly Gln His His His His His His 
        355                 360                 365     


<210>  10
<211>  720
<212>  DNA
<213>  human

<400>  10
ttaaagggag atgagggaat hcagggatta mgaggaccaw saggagtacc aggattacca     60

gcattawsag gagtaccagg agcattagga ccacagggat ttccaggatt aaagggagat    120

cagggaaatc caggamgaac aacaathgga gcagcaggat taccaggamg agatggatta    180

ccaggaccac caggaccacc aggaccacca wsaccagagt ttgagacaga gacattacat    240

aataaggagw saggatttcc aggattamga ggagagcagg gaccaaaggg aaatttagga    300

ttaaagggaa thaagggaga twsaggattt tgtgcatgtg atggaggagt accaaataca    360

ggaccaccag gagagccagg accaccagga ccatggggat taathggatt accaggatta    420

aagggagcam gaggagatmg aggawsagga ggagcacagg gaccagcagg agcaccagga    480

ttagtaggac cattaggacc awsaggacca aagggaaaga agggagagcc aathttawsa    540

acaathcagg gaatgccagg agatmgagga gatwsaggaw sacagggatt tmgaggagta    600

athggagagc caggaaagga tggagtacca ggattaccag gattaccagg attaccagga    660

gatggaggac agggatttcc aggagagaag ggattaccag gattaccagg agagaaggga    720


<210>  11
<211>  306
<212>  DNA
<213>  human

<400>  11
ttttattcat gtacaacaga gggamgacag gatggacatt tatggtgttc aacaacatca     60

aattatgagc aggatcagaa gtattcattt tgtacagatc atacagtatt agtacagaca    120

mgaggaggaa attcaaatgg agcattatgt cattttccat ttttatataa taatcataat    180

tatacagatt gtacatcaga gggamgamga gataatatga agtggtgtgg aacaacacag    240

aattatgatg cagatcagaa gtttggattt tgtccaatgg cagcacatga ggagathtgt    300

acaaca                                                               306


<210>  12
<211>  1149
<212>  DNA
<213>  human

<400>  12
ctcgagaaaa gagaggctga agctcatcat catcatcatc atttaaaggg agatgaggga     60

attcagggat tacgaggacc atgaggagta ccaggattac cagcattatg aggagtacca    120

ggagcattag gaccacaggg atttccagga ttaaagggag atcagggaaa tccaggacga    180

acaacaattg gagcagcagg attaccagga cgagatggat taccaggacc accaggacca    240

ccaggaccac catgaccaga gtttgagaca gagacattac ataataagga gtgaggattt    300

ccaggattac gaggagagca gggaccaaag ggaaatttag gattaaaggg aattaaggga    360

gattgaggat tttgtgcatg tgatggagga gtaccaaata caggaccacc aggagagcca    420

ggaccaccag gaccatgggg attaattgga ttaccaggat taaagggagc acgaggagat    480

cgaggatgag gaggagcaca gggaccagca ggagcaccag gattagtagg accattagga    540

ccatgaggac caaagggaaa gaagggagag ccaattttat gaacaattca gggaatgcca    600

ggagatcgag gagattgagg atgacaggga tttcgaggag taattggaga gccaggaaag    660

gatggagtac caggattacc aggattacca ggattaccag gagatggagg acagggattt    720

ccaggagaga agggattacc aggattacca ggagagaagg gaggttctga aggttctgaa    780

ggtgaaggtg gttctgaagg ttctgaaggt gaaggttttt attcatgtac aacagaggga    840

mgacaggatg gacatttatg gtgttcaaca acatcaaatt atgagcagga tcagaagtat    900

tcattttgta cagatcatac agtattagta cagacamgag gaggaaattc aaatggagca    960

ttatgtcatt ttccattttt atataataat cataattata cagattgtac atcagaggga   1020

mgamgagata atatgaagtg gtgtggaaca acacagaatt atgatgcaga tcagaagttt   1080

ggattttgtc caatggcagc acatgaggag athtgtacaa cacatcatca tcatcatcat   1140

taatctaga                                                           1149


<210>  13
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  rhCol-rhFN-F

<400>  13
ctcgagaaaa gagag                                                      15


<210>  14
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  rhCol-rhFN-R

<400>  14
catcattaat ctaga                                                      15


<210>  15
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  rhCol-F

<400>  15
gaattcttaa agggagat                                                   18


<210>  16
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  rhCol-R

<400>  16
tgtacaacag cggccgc                                                    17


<210>  17
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  rhFN-F

<400>  17
ctcgagtttt attca                                                      15


<210>  18
<211>  14
<212>  DNA
<213>  artificial sequence

<220>
<223>  rhFN- R

<400>  18
acaacagcgg ccgc                                                       14


