                         SEQUENCE LISTING

<110>  Huahui Health Ltd.
 
<120>  Human monoclonal antibodies against TIGIT for immune related 
       diseases

<130>  CR12807HHH33CN

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 consensus sequence LCDR1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S, I or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is S, K, N, or T

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is S, K, N, or R

<400>  1

Arg Ala Ser Gln Xaa Ile Xaa Xaa Tyr Leu Asn 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 consensus sequence LCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A, L, S, or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is A, or T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is S, or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, I, or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Q, P, or E

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is S, N, or R

<400>  2

Xaa Xaa Xaa Xaa Leu Xaa Xaa 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 consensus sequence LCDR3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Q, or H

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Y, or H

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S, A, T, or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is T, P, or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is P, or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is T, S, or I

<400>  3

Gln Xaa Ser Xaa Xaa Xaa Xaa Ile Xaa 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 HCDR1

<400>  4

Asp Tyr Tyr Trp Thr 
1               5   


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 HCDR2

<400>  5

Glu Ile Thr His Ser Gly Ser Ala Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 HCDR3

<400>  6

Gly Leu Lys Leu Phe Arg Trp Lys Lys Thr Thr Val Thr Thr Phe Pro 
1               5                   10                  15      


Pro Tyr Tyr Tyr Gly Met Asp Val 
            20                  


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 VL consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Q, or V

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is M, or L

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is V, I, or L

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is R, or T

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is V, or I

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is T, or A

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is T, or S

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is S, I, or N

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is S, K, N, or T

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is S, K, N, or R

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X is K, or R

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is R, or S

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is K, E, or T

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is I, or V

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X is Y, or S

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  X is A, L, S, or T

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is A, or T

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  X is S, or Y

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is S, I, or T

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is Q, P, or E

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is S, N, or R

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  X is S, or R

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  X is G, or R

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is G, or E

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is S, or N

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is Q, or E

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is A, or G

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is Y, or F

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  X is Q, or H

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is Y, or H

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is S, A, T, or N

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  X is T, P, or V

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  X is P, or S

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X is T, S, or I

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  X is Q, G, or P

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X is G, or R

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X is R, or K

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  X is E, or D

<400>  7

Asp Ile Xaa Xaa Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Xaa Gly 
1               5                   10                  15      


Asp Xaa Xaa Xaa Ile Xaa Cys Arg Ala Ser Gln Xaa Ile Xaa Xaa Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Xaa Pro Gly Lys Xaa Pro Xaa Leu Leu Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Gly Val Pro Ser Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Xaa Ser Xaa Thr Asp Phe Thr Leu Thr Ile Xaa Ser Leu Xaa Pro 
65                  70                  75                  80  


Glu Asp Phe Xaa Thr Tyr Xaa Cys Gln Xaa Ser Xaa Xaa Xaa Xaa Ile 
                85                  90                  95      


Xaa Phe Gly Xaa Xaa Thr Xaa Leu Xaa Ile Lys 
            100                 105         


<210>  8
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 VH

<400>  8

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Thr His Ser Gly Ser Ala Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Lys Leu Phe Arg Trp Lys Lys Thr Thr Val Thr Thr Phe 
            100                 105                 110         


Pro Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4M LCDR1

<400>  9

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4M LCDR2

<400>  10

Ser Ala Tyr Ser Leu Gln Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4M LCDR3

<400>  11

Gln Gln Ser Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4M VL

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Tyr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T4M VL nucleotide


<220>
<221>  misc_feature
<222>  (70)..(102)

<220>
<221>  misc_feature
<222>  (148)..(168)

<220>
<221>  misc_feature
<222>  (265)..(291)

<400>  13
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct gcatacagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccccgatcac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210>  14
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T4 VH nucleotide


<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  HCDR1 coding sequence

<220>
<221>  misc_feature
<222>  (148)..(195)
<223>  HCDR2 coding sequence

<220>
<221>  misc_feature
<222>  (292)..(363)
<223>  HCDR3 coding sequence

<400>  14
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtcattcaat gattactact ggacctggat ccgccaggcc      120

ccagggaagg ggctggagtg gattggggaa atcactcaca gtggaagcgc cgactacaat      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgaggt ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agggctcaaa      300

ctttttcgtt ggaaaaagac tacggtgact acgttccccc cttactacta cggtatggac      360

gtctggggcc aagggaccac ggtcaccgtc tcctca                                396


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 LCDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T, or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, I, G, or N

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S, or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is G, R, S, or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is Y, or H

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is N, P, D, or S

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is F, or Y

<400>  15

Thr Gly Xaa Xaa Xaa Asp Val Gly Xaa Xaa Xaa Xaa Val Ser 
1               5                   10                  


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 cons LCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is E, D, Y, A, or G

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is V, A, or G

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is S, T, N, H, G, I, or R

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is K, or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is P, or A

<400>  16

Xaa Xaa Xaa Xaa Arg Xaa Ser 
1               5           


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 cons LCDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, R, A, T, or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S, G, R, or absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is S, M, P, or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is G, S, P, T, N, or E

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is S, H, G, T, N, or P

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is T, Q, A, P, G, V, K, or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is R, S, T, G, L, K, N, H, A, or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is L, or V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is V, L, or I

<400>  17

Ser Ser Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 cons HCDR1

<400>  18

Ser Tyr Ala Met His 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 cons HCDR2

<400>  19

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 cons HCDR3

<400>  20

Leu Glu Gly Gly Gly Arg Tyr Tyr Asp Phe Trp Ser Ala Asp Tyr 
1               5                   10                  15  


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 cons VL


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is S, A or P

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is A, G, or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is R, A, or P

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is V, or A

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is G, A, or E

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is V, or I

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is I, or V

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is T, or S

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is S, I, G, or N

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is S, or R

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is G, R, S, or absent

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is Y, or H

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is N, P, D, or S

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is F, or Y

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is Q, or H

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X is H, D, Y, or N

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is G, or D

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is A, or V

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  X is K, or R

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X is M, I, or L

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  X is I, or L

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is Y, or F

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  X is E, D, Y, A, or G

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is V, A, or G

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  X is S, T, N, H, G, I, or R

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is K, or N

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X is P, or A

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is P, S, or T

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is D, N, A, or S

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  X is G, or A

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  X is S, or A

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is G, or D

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  X is N, S, or T

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is S, or F

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  X is I, or V

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  X is S, or T

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is Q, or L

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  X is A, T, S, or P

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is E, or D

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is A, or S

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is D, H, Q, or I

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  X is Y, or H

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  X is S, R, A, T, or G

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  X is S, G, R, or absent

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  X is S, M, P, or absent

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X is G, S, P, T, N, or E

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  X is S, H, G, T, N, or P

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  X is T, Q, A, P, G, V, K, or absent

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  X is R, S, T, G, L, K, N, H, A, or absent

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X is L, or V

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  X is V, L, or I

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  X is K, or Q

<400>  21

Gln Xaa Xaa Leu Thr Gln Pro Xaa Ser Xaa Ser Xaa Ser Pro Gly Gln 
1               5                   10                  15      


Ser Xaa Thr Xaa Ser Cys Thr Gly Xaa Xaa Xaa Asp Val Gly Xaa Xaa 
            20                  25                  30          


Xaa Xaa Val Ser Trp Tyr Gln Xaa Xaa Pro Xaa Lys Xaa Pro Xaa Leu 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Ser Gly Val Xaa Xaa Arg Phe 
    50                  55                  60                  


Ser Xaa Xaa Lys Ser Xaa Xaa Thr Ala Xaa Leu Thr Xaa Xaa Gly Leu 
65                  70                  75                  80  


Xaa Xaa Xaa Asp Glu Xaa Xaa Tyr Xaa Cys Ser Ser Tyr Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Phe Gly Gly Gly Thr Xaa Leu Thr Val Leu 
            100                 105                 110         


<210>  22
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hm7 cons VH

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Glu Gly Gly Gly Arg Tyr Tyr Asp Phe Trp Ser Ala Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME LCDR1 AA

<400>  23

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser 
1               5                   10                  


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME LCDR2

<400>  24

Ala Val Ser Lys Arg Pro Ser 
1               5           


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME LCDR3

<400>  25

Ser Ser Tyr Ser Ser Glu Ser Thr Arg Val Val 
1               5                   10      


<210>  26
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME VL

<400>  26

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Ser Glu 
                85                  90                  95      


Ser Thr Arg Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  27
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME3-23 VH

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Glu Gly Gly Gly Arg Tyr Tyr Asp Phe Trp Ser Ala Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  28
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS19ME VL NA


<220>
<221>  misc_feature
<222>  (67)..(108)
<223>  LCDR1 coding sequence

<220>
<221>  misc_feature
<222>  (154)..(174)
<223>  LCDR2 coding sequence

<220>
<221>  misc_feature
<222>  (271)..(303)
<223>  LCDR3 coding sequence

<400>  28
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttataact ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcctgatt tatgctgtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatatt caagcgagag cactagggtg      300

gttttcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  29
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS19ME3-23 VH NA


<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  HCDR1 coding sequence

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  HCDR2 coding sequence

<220>
<221>  misc_feature
<222>  (295)..(339)
<223>  HCDR3 coding sequence

<400>  29
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gactctcgag      300

ggagggggac ggtattacga tttttggagc gctgactact ggggccaggg aaccctggtc      360

accgtctctt ca                                                          372


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME-N LCDR1

<400>  30

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser 
1               5                   10                  


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME-N LCDR2

<400>  31

Ala Val Ser Asn Arg Pro Ser 
1               5           


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME-N LCDR3

<400>  32

Ser Ser Tyr Ser Ser Glu Ser Thr Arg Val Val 
1               5                   10      


<210>  33
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME-N VL

<400>  33

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Val Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Ser Glu 
                85                  90                  95      


Ser Thr Arg Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  34
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS19ME3-30-N VH

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Glu Gly Gly Gly Arg Tyr Tyr Asp Phe Trp Ser Ala Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  35
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS19ME-N VL NA


<220>
<221>  misc_feature
<222>  (67)..(108)
<223>  LCDR1 coding sequence

<220>
<221>  misc_feature
<222>  (154)..(174)
<223>  LCDR2 coding sequence

<220>
<221>  misc_feature
<222>  (271)..(303)
<223>  LCDR3 coding sequence

<400>  35
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttataact ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcctgatt tatgctgtca gtaaccggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatatt caagcgagag cactagggtg      300

gttttcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  36
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS19ME3-30-N VH NA


<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  HCDR1 coding sequence

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  HCDR2 coding sequence

<220>
<221>  misc_feature
<222>  (295)..(339)
<223>  HCDR3 coding sequence

<400>  36
caggtgcagc tggtggagtc tgggggaggc gtggtacagc ctgggcggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gactctcgag      300

ggagggggac ggtattacga tttttggagc gctgactact ggggccaggg aaccctggtc      360

accgtctctt ca                                                          372


