                         SEQUENCE LISTING

<110>  Monash University
       Baker Heart and Diabetes Institute
 
<120>  Anti-VWF antibodies and uses thereof

<130>  53135941AZD

<150>  AU 2020902148
<151>  2020-06-26

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Mouse

<400>  1

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10          


<210>  2
<211>  7
<212>  PRT
<213>  Mouse

<400>  2

Leu Val Ser Asn Leu Glu Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Mouse

<400>  3

Gln His Ile Arg Glu Leu Thr Arg Ser 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Mouse

<400>  4

Asn Tyr Trp Met Ser 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Mouse

<400>  5

Met Ile His Pro Ser Asp Ser Asp Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  6
<211>  7
<212>  PRT
<213>  Mouse

<400>  6

Phe Glu Gly Trp Leu Pro Val 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Mouse

<400>  7

Gly Tyr Ser Phe Thr Asn Tyr Trp Met 
1               5                   


<210>  8
<211>  6
<212>  PRT
<213>  Mouse

<400>  8

His Pro Ser Asp Ser Asp 
1               5       


<210>  9
<211>  7
<212>  PRT
<213>  Mouse

<400>  9

Phe Glu Gly Trp Leu Pro Val 
1               5           


<210>  10
<211>  107
<212>  PRT
<213>  Mouse

<400>  10

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Ser Tyr Arg Ala Ser Cys Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu 
65                  70                  75                  80  


Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg Glu Leu Thr 
                85                  90                  95      


Arg Ser Glu Gly Asp Gln Ala Glu Ile Asn Arg 
            100                 105         


<210>  11
<211>  119
<212>  PRT
<213>  Mouse

<400>  11

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Asp Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Gly Leu Leu Leu 
                85                  90                  95      


Cys Lys Lys Phe Glu Gly Trp Leu Pro Val Leu Leu Gly Pro Arg His 
            100                 105                 110         


His Ser His Ser Leu Leu Ser 
        115                 


<210>  12
<211>  36
<212>  DNA
<213>  Mouse

<400>  12
aagagcgtgt ccacctccgg ctactcttac atgcac                                 36


<210>  13
<211>  21
<212>  DNA
<213>  Mouse

<400>  13
ctggtgtcca acctggaaag c                                                 21


<210>  14
<211>  27
<212>  DNA
<213>  Mouse

<400>  14
cagcacatca gagagctgac cagaagc                                           27


<210>  15
<211>  15
<212>  DNA
<213>  Mouse

<400>  15
aactactgga tgagc                                                        15


<210>  16
<211>  51
<212>  DNA
<213>  Mouse

<400>  16
atgatccacc ccagcgacag cgacacccgg ctgaaccaga agttcaagga c                51


<210>  17
<211>  21
<212>  DNA
<213>  Mouse

<400>  17
ttcgagggct ggctgcccgt g                                                 21


<210>  18
<211>  27
<212>  DNA
<213>  Mouse

<400>  18
ggctacagct tcaccaacta ctggatg                                           27


<210>  19
<211>  18
<212>  DNA
<213>  Mouse

<400>  19
caccccagcg acagcgac                                                     18


<210>  20
<211>  21
<212>  DNA
<213>  Mouse

<400>  20
ttcgagggct ggctgcccgt g                                                 21


<210>  21
<211>  321
<212>  DNA
<213>  Mouse

<400>  21
gatatcgagc tgacacagag ccctgccagc ctggccgtgt ctctgggcca gagctataga       60

gccagctgca agagcgtgtc cacctccggc tactcttaca tgcactggaa ccagcagaag      120

cccggccagc cccctagact gctgatctac ctggtgtcca acctggaaag cggcgtgccc      180

gccagatttt ctggctctgg cagcggcacc gacttcaccc tgaacatcca ccccgtggaa      240

gaagaggacg ccgccaccta ctactgccag cacatcagag agctgaccag aagcgagggc      300

gaccaggccg agatcaatag a                                                321


<210>  22
<211>  357
<212>  DNA
<213>  Mouse

<400>  22
caggtgcagc tgcagcagcc tggcgctgaa ctcgtgcggc caggcgcttc tgtgaagctg       60

agctgtaaag ccagcggcta cagcttcacc aactactgga tgagctgggt caagcagagg      120

ccaggccagg gcctggaatg gatcggcatg atccacccca gcgacagcga cacccggctg      180

aaccagaagt tcaaggacaa ggccaccctg accgtggaca agagcagcag caccgcctac      240

atgcagctgt ccagccccac cagcgaggat tctgctggac tgctgctgtg caagaagttc      300

gagggctggc tgcccgtgct gctgggacct agacaccact ctcacagcct gctgtct         357


<210>  23
<211>  23
<212>  PRT
<213>  Mouse

<400>  23

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Ser Tyr Arg Ala Ser Cys 
            20              


<210>  24
<211>  15
<212>  PRT
<213>  Mouse

<400>  24

Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  25
<211>  32
<212>  PRT
<213>  Mouse

<400>  25

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  26
<211>  9
<212>  PRT
<213>  Mouse

<400>  26

Glu Gly Asp Gln Ala Glu Ile Asn Arg 
1               5                   


<210>  27
<211>  30
<212>  PRT
<213>  Mouse

<400>  27

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  


<210>  28
<211>  14
<212>  PRT
<213>  Mouse

<400>  28

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  29
<211>  33
<212>  PRT
<213>  Mouse

<400>  29

Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Gly Leu Leu Leu Cys Lys 
            20                  25                  30          


Lys 
    


<210>  30
<211>  13
<212>  PRT
<213>  Mouse

<400>  30

Leu Leu Gly Pro Arg His His Ser His Ser Leu Leu Ser 
1               5                   10              


<210>  31
<211>  25
<212>  PRT
<213>  Mouse

<400>  31

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  32
<211>  17
<212>  PRT
<213>  Mouse

<400>  32

Ser Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met 
1               5                   10                  15      


Ile 
    


<210>  33
<211>  42
<212>  PRT
<213>  Mouse

<400>  33

Thr Arg Leu Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp 
1               5                   10                  15      


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu 
            20                  25                  30          


Asp Ser Ala Gly Leu Leu Leu Cys Lys Lys 
        35                  40          


<210>  34
<211>  13
<212>  PRT
<213>  Mouse

<400>  34

Leu Leu Gly Pro Arg His His Ser His Ser Leu Leu Ser 
1               5                   10              


<210>  35
<211>  69
<212>  DNA
<213>  Mouse

<400>  35
gatatcgagc tgacacagag ccctgccagc ctggccgtgt ctctgggcca gagctataga       60

gccagctgc                                                               69


<210>  36
<211>  45
<212>  DNA
<213>  Mouse

<400>  36
tggaaccagc agaagcccgg ccagccccct agactgctga tctac                       45


<210>  37
<211>  96
<212>  DNA
<213>  Mouse

<400>  37
ggcgtgcccg ccagattttc tggctctggc agcggcaccg acttcaccct gaacatccac       60

cccgtggaag aagaggacgc cgccacctac tactgc                                 96


<210>  38
<211>  27
<212>  DNA
<213>  Mouse

<400>  38
gagggcgacc aggccgagat caataga                                           27


<210>  39
<211>  90
<212>  DNA
<213>  Mouse

<400>  39
caggtgcagc tgcagcagcc tggcgctgaa ctcgtgcggc caggcgcttc tgtgaagctg       60

agctgtaaag ccagcggcta cagcttcacc                                        90


<210>  40
<211>  42
<212>  DNA
<213>  Mouse

<400>  40
tgggtcaagc agaggccagg ccagggcctg gaatggatcg gc                          42


<210>  41
<211>  99
<212>  DNA
<213>  Mouse

<400>  41
aaggccaccc tgaccgtgga caagagcagc agcaccgcct acatgcagct gtccagcccc       60

accagcgagg attctgctgg actgctgctg tgcaagaag                              99


<210>  42
<211>  39
<212>  DNA
<213>  Mouse

<400>  42
ctgctgggac ctagacacca ctctcacagc ctgctgtct                              39


<210>  43
<211>  75
<212>  DNA
<213>  Mouse

<400>  43
caggtgcagc tgcagcagcc tggcgctgaa ctcgtgcggc caggcgcttc tgtgaagctg       60

agctgtaaag ccagc                                                        75


<210>  44
<211>  51
<212>  DNA
<213>  Mouse

<400>  44
agctgggtca agcagaggcc aggccagggc ctggaatgga tcggcatgat c                51


<210>  45
<211>  126
<212>  DNA
<213>  Mouse

<400>  45
acccggctga accagaagtt caaggacaag gccaccctga ccgtggacaa gagcagcagc       60

accgcctaca tgcagctgtc cagccccacc agcgaggatt ctgctggact gctgctgtgc      120

aagaag                                                                 126


<210>  46
<211>  39
<212>  DNA
<213>  Mouse

<400>  46
ctgctgggac ctagacacca ctctcacagc ctgctgtct                              39


<210>  47
<211>  208
<212>  PRT
<213>  Human

<400>  47

Asp Ile Ser Glu Pro Pro Leu His Asp Phe Tyr Cys Ser Arg Leu Leu 
1               5                   10                  15      


Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu Ala Glu 
            20                  25                  30          


Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg Leu Arg 
        35                  40                  45              


Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His Asp Gly 
    50                  55                  60                  


Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu Leu 
65                  70                  75                  80  


Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala Ser 
                85                  90                  95      


Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys Ile 
            100                 105                 110         


Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu Leu Leu Met Ala Ser Gln 
        115                 120                 125             


Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln Gly Leu 
    130                 135                 140                 


Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro His Ala 
145                 150                 155                 160 


Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu Asn Lys 
                165                 170                 175     


Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg Asp Glu 
            180                 185                 190         


Ile Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro Pro Thr 
        195                 200                 205             


