                         SEQUENCE LISTING

<110>  Kira Biotech Pty Limited
 
<120>  Combination therapy

<130>  53134173AZD

<150>  2020902090
<151>  2020-06-23

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  205
<212>  PRT
<213>  Human

<400>  1

Met Ser Arg Gly Leu Gln Leu Leu Leu Leu Ser Cys Ala Tyr Ser Leu 
1               5                   10                  15      


Ala Pro Ala Thr Pro Glu Val Lys Val Ala Cys Ser Glu Asp Val Asp 
            20                  25                  30          


Leu Pro Cys Thr Ala Pro Trp Asp Pro Gln Val Pro Tyr Thr Val Ser 
        35                  40                  45              


Trp Val Lys Leu Leu Glu Gly Gly Glu Glu Arg Met Glu Thr Pro Gln 
    50                  55                  60                  


Glu Asp His Leu Arg Gly Gln His Tyr His Gln Lys Gly Gln Asn Gly 
65                  70                  75                  80  


Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser Leu Lys Ile Arg Asn 
                85                  90                  95      


Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys Thr Leu Gln Asp Pro 
            100                 105                 110         


Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile Leu Arg Val Thr Gly 
        115                 120                 125             


Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys Lys Tyr Arg Ala Glu 
    130                 135                 140                 


Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Thr Leu Ile Ile 
145                 150                 155                 160 


Phe Thr Cys Lys Phe Ala Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser 
                165                 170                 175     


Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val Thr Ser Pro Asn Lys 
            180                 185                 190         


His Leu Gly Leu Val Thr Pro His Lys Thr Glu Leu Val 
        195                 200                 205 


<210>  2
<211>  204
<212>  PRT
<213>  Human

<400>  2

Met Ser Arg Gly Leu Gln Leu Leu Leu Leu Ser Cys Ala Tyr Ser Leu 
1               5                   10                  15      


Ala Pro Ala Thr Pro Glu Val Lys Val Ala Cys Ser Glu Asp Val Asp 
            20                  25                  30          


Leu Pro Cys Thr Ala Pro Trp Asp Pro Gln Val Pro Tyr Thr Val Ser 
        35                  40                  45              


Trp Val Lys Leu Leu Glu Gly Gly Glu Glu Arg Met Glu Thr Pro Gln 
    50                  55                  60                  


Glu Asp His Leu Arg Gly Gln His Tyr His Gln Lys Gly Gln Asn Gly 
65                  70                  75                  80  


Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser Leu Lys Ile Arg Asn 
                85                  90                  95      


Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys Thr Leu Gln Asp Pro 
            100                 105                 110         


Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile Leu Arg Val Thr Gly 
        115                 120                 125             


Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys Lys Tyr Arg Ala Glu 
    130                 135                 140                 


Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Thr Leu Ile Ile 
145                 150                 155                 160 


Phe Thr Cys Phe Ala Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser Lys 
                165                 170                 175     


Ala Gly Met Glu Arg Ala Phe Leu Pro Val Thr Ser Pro Asn Lys His 
            180                 185                 190         


Leu Gly Leu Val Thr Pro His Lys Thr Glu Leu Val 
        195                 200                 


<210>  3
<211>  146
<212>  PRT
<213>  Human

<400>  3

Met Glu Thr Pro Gln Glu Asp His Leu Arg Gly Gln His Tyr His Gln 
1               5                   10                  15      


Lys Gly Gln Asn Gly Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser 
            20                  25                  30          


Leu Lys Ile Arg Asn Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys 
        35                  40                  45              


Thr Leu Gln Asp Pro Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile 
    50                  55                  60                  


Leu Arg Val Thr Gly Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys 
65                  70                  75                  80  


Lys Tyr Arg Ala Glu Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr 
                85                  90                  95      


Leu Thr Leu Ile Ile Phe Thr Cys Lys Phe Ala Arg Leu Gln Ser Ile 
            100                 105                 110         


Phe Pro Asp Phe Ser Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val 
        115                 120                 125             


Thr Ser Pro Asn Lys His Leu Gly Leu Val Thr Pro His Lys Thr Glu 
    130                 135                 140                 


Leu Val 
145     


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  4

Ser Tyr Ala Met His 
1               5   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  5

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  6

His Tyr Tyr Tyr Gly Met Asp Val 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  7

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  8

Ala Thr Ser Thr Leu Gln Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  9

Gln Gln Val Asp Arg Phe Pro Tyr Thr 
1               5                   


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  10

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu His Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asp Arg Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  12

Glu Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Lys Asn Tyr 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Gly Ala Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  13

Glu Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Thr Ser Gln Gly Ile Ser Asn His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Leu Lys 
            100                 105         


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  14

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Leu Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  15

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Cys Asn Ser Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  16
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  16

Glu Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Lys Asn Tyr 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Gly Ala Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  17
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  17

Glu Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Thr Ser Gln Gly Ile Ser Asn His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  18
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu His Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asp Arg Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  19
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  19

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Leu Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  20
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Cys Asn Ser Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  21

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  22
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH amino acid sequence of 1F7

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Gly Ala Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Leu Asp Ile Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ala Ala Ala 
    210                 215                 220     


<210>  23
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ligh chain VL amin acid sequence of 1F7

<400>  23

Leu Thr Gln Pro Pro Pro Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
1               5                   10                  15      


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
            20                  25                  30          


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
        35                  40                  45              


Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Ala Ser Lys 
    50                  55                  60                  


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
65                  70                  75                  80  


Glu Ala His Tyr Tyr Cys Ala Ala Trp Asp Gly Ser Leu Asn Gly Gly 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Val Thr Leu Gly 
            100                 105             


<210>  24
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.1

<400>  24

Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
1               5                   10                  15      


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Pro Val Asn 
            20                  25                  30          


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Thr 
        35                  40                  45              


Thr Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Leu 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 


<210>  25
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.2

<400>  25

Met Thr His Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys 
            20                  25                  30          


Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Gln Pro 
        35                  40                  45              


Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser Leu Gln Leu 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  26
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.3

<400>  26

Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile His Ser Asp Gly Asn 
            20                  25                  30          


Thr Tyr Leu Asp Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg 
        35                  40                  45              


Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Ala Thr His Trp 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.4

<400>  27

Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Asp Ser Ala Gly Asn 
            20                  25                  30          


Thr Phe Leu His Trp Phe His Gln Arg Pro Gly Gln Ser Pro Arg Arg 
        35                  40                  45              


Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Thr His Trp 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  28
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.5

<400>  28

Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val Asp Ser Asp Gly Asn 
            20                  25                  30          


Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg 
        35                  40                  45              


Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Thr His Trp 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  29
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.7

<400>  29

Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn 
            20                  25                  30          


Met Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg 
        35                  40                  45              


Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Thr Gln Pro 
                85                  90                  95      


Thr Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110 


<210>  30
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.8

<400>  30

Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
1               5                   10                  15      


Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala 
        35                  40                  45              


Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe 
65                  70                  75                  80  


Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Trp Pro Arg Thr Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105 


<210>  31
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.9

<400>  31

Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly His Pro Val 
1               5                   10                  15      


Thr Ile Thr Cys Arg Ala Ser Gln Ser Leu Ile Ser Tyr Leu Asn Trp 
            20                  25                  30          


Tyr His Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
        35                  40                  45              


Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asn Phe 
65                  70                  75                  80  


Ala Ser Tyr Tyr Cys Gln His Thr Asp Ser Phe Pro Arg Thr Phe Gly 
                85                  90                  95      


His Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105 


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.10

<400>  32

Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Gly Val Thr 
1               5                   10                  15      


Ile Ser Cys Arg Gly Ser Thr Ser Asn Ile Gly Asn Asn Val Val Asn 
            20                  25                  30          


Trp Tyr Gln His Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Trp Ser 
        35                  40                  45              


Asn Ile Gln Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
65                  70                  75                  80  


Glu Ala Val Tyr Tyr Cys Ala Val Trp Asp Asp Gly Leu Ala Gly Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Thr Val Thr Val Leu Ser 
            100                 105             


<210>  33
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.12

<400>  33

Met Thr Gln Ala Pro Val Val Ser Val Ala Leu Glu Gln Thr Val Arg 
1               5                   10                  15      


Ile Thr Cys Gln Gly Asp Ser Leu Ala Ile Tyr Tyr Asp Phe Trp Tyr 
            20                  25                  30          


Gln His Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn 
        35                  40                  45              


Asn Arg Pro Ser Gly Ile Pro His Arg Phe Ser Gly Ser Ser Ser Asn 
    50                  55                  60                  


Thr Asp Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
                85                  90                  95      


Gly Gly Thr Asn Leu Thr Val Leu Gly 
            100                 105 


<210>  34
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain VL amino acid sequence of hFab4.18

<400>  34

Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Lys Ser Asn Gln Ser Leu Val His Ser Asp Gly Asn 
            20                  25                  30          


Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg 
        35                  40                  45              


Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Asn Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly Thr Gln Trp 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys Arg 
            100                 105                 110 


<210>  35
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IF7 heavy chain amino acid sequence

<400>  35

Gln Pro Ala Met Ala Glu Val Gln Leu Val Gln Ser Gly Gly Ala Val 
1               5                   10                  15      


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            20                  25                  30          


Thr Phe Ser Thr Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Gly Leu Glu Trp Val Ala Ala Val Ser Tyr Asp Gly Ser Asn Lys Tyr 
    50                  55                  60                  


Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ala Ala His His His His His His Gly Pro Gln Ile Arg 
225                 230                 235         


<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of IF7 light chain

<400>  36

Leu Thr Gln Pro Pro Pro Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
1               5                   10                  15      


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
            20                  25                  30          


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
        35                  40                  45              


Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Ala Ser Lys 
    50                  55                  60                  


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
65                  70                  75                  80  


Glu Ala His Tyr Tyr Cys Ala Ala Trp Asp Gly Ser Leu Asn Gly Gly 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence of CDR1 of 3C12


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or S or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or H or W

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  F or L

<400>  37

Arg Xaa Ser Gln Gly Ile Xaa Xaa Xaa Xaa Ala 
1               5                   10      


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL consensus sequence of CDR2 of 3C12


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N or S or T

<400>  38

Ala Xaa Ser Xaa Leu Gln Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL consensus sequence of CDR3 of 3C12


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Q or K

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L or V or C

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  G or N or D or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  A or S or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Y or F or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Y or L

<400>  39

Gln Xaa Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL consensus sequence of 3C12


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  V or Q

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  M or L

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  L or F or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  K or S or R

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Y or H or W

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  F or L

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  N or S or T

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  G or R

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  E or D or H

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Q or H

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  F or I or V

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Q or K

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  L or V or C

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  G or N or D or S

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  A or S or R

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Y or F or A

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  L or Y

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  G or Q

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  L or V

<400>  40

Glu Xaa Xaa Xaa Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Xaa Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys Arg Xaa Ser Gln Gly Ile Xaa Xaa Xaa 
            20                  25                  30          


Xaa Ala Trp Tyr Gln Gln Xaa Pro Gly Lys Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Xaa Ser Xaa Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Xaa Ser Gly Thr Xaa Phe Thr Leu Thr Ile Ser Ser Leu Xaa Pro 
65                  70                  75                  80  


Xaa Asp Xaa Ala Thr Tyr Tyr Cys Gln Xaa Xaa Xaa Xaa Xaa Pro Xaa 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Xaa Xaa Glu Leu Lys 
            100                 105         


<210>  41
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C12 heavy chain

<400>  41
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactccgag       60

gtgcagctgc aggagtcggg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcct ctggattcac cttcagtagc tatgctatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tcatatgatg gaagcaataa atactacgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctatgtatt actgtgcgag acactactac      360

tacggtatgg acgtctgggg ccaagggacc acgctcaccg tgtcctccgc ctccaccaag      420

ggcccttccg tgttccctct ggccccttcc tccaagtcca cctccggcgg caccgccgct      480

ctgggctgcc tggtgaagga ctacttccct gagcctgtga ccgtgtcctg gaactctggc      540

gccctgacct ctggcgtgca cacctttcct gctgtcctgc agtcctccgg cctgtactcc      600

ctgtcctccg tggtgaccgt gccttcctcc tccctgggca cccagaccta catctgcaac      660

gtgaaccaca agccttccaa caccaaggtg gacaagaagg tggagcctaa gtcctgcgac      720

aagacccaca cctgccctcc ctgccctgcc cctgagctgc tgggcggacc ctccgtgttc      780

ctgttccctc ctaagcctaa ggacaccctg atgatctccc ggacccctga ggtgacctgc      840

gtggtggtgg acgtgtccca cgaggatcct gaggtgaagt tcaattggta cgtggacggc      900

gtggaggtgc acaacgccaa gaccaagcct cgggaagagc agtacaactc cacctaccgg      960

gtggtgtctg tgctgaccgt gctgcaccag gactggctga acggcaagga atacaagtgc     1020

aaggtgtcca acaaggccct gcctgctccc atcgagaaga ccatctccaa ggccaagggc     1080

cagcctcgcg agcctcaggt gtataccctg cctccctccc gggacgagct gaccaagaac     1140

caggtgtccc tgacctgtct ggtgaagggc ttctaccctt ccgatatcgc cgtggagtgg     1200

gagtccaacg gccagcctga gaacaactac aagaccaccc ctcctgtgct ggactccgac     1260

ggctccttct tcctgtactc caagctgacc gtggacaagt cccggtggca gcagggcaac     1320

gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1380

tccctgtctc ctggcaagtg a                                               1401


<210>  42
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C12 light chain

<400>  42
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcactccgag       60

atcgtgatga cccagtctcc atccctcctg tctgcttctt taggagacag agtcaccatc      120

acttgtcggg ccagtcaggg cattaagaat tattttgcct ggtatcagca aagaccaggg      180

aaagccccta agctcctgat ctatgctaca tccaatttgc aaagtggggt cccatcacga      240

ttcagcggca gtggatctgg gacagaattc actctgacaa tcagcagcct gcagcctgaa      300

gattttgcaa cttactattg tcaacaactt ggcgcttacc cactcacttt cggcgggggg      360

accaagctgg aactcaagcg gaccgtggcc gctccttccg tgttcatctt ccctccctcc      420

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      540

tccgtcaccg agcaggactc caaggactct acctactccc tgtcctccac cctgaccctg      600

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      660

tcctctcccg tgaccaagtc cttcaaccgg ggcgagtgct ga                         702


<210>  43
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C12.B light chain

<400>  43
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcactccgag       60

gttgtgatga cccagtcccc cagcttcctg tccgcctcta tcggcgaccg ggtgtccatc      120

acctgtcgga cctcccaggg catctccaac cacctggcct ggtatcagca gaagcccggc      180

aaggccccca agctgctgat ctacgccgcc tccagcctgc agtccggcgt gccatccaga      240

ttctccggct ccggcagcgg caccgacttc accctgacca tcagctccct gcagcccgag      300

gatatcgcca cctactactg ccagcaggtg aactcctacc cctacacctt cggccagggg      360

acacgactgg agctcaagcg gaccgtggcc gctccttccg tgttcatctt ccctccctcc      420

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      540

tccgtcaccg agcaggactc caaggactct acctactccc tgtcctccac cctgaccctg      600

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      660

tcctctcccg tgaccaagtc cttcaaccgg ggcgagtgct ga                         702


<210>  44
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C12C light chain

<400>  44
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcactccgag       60

attgtgctga ctcagtcccc ctccagcctg tccgcctccg tgggcgacag agtgaccatc      120

acctgtcggg cctcccaggg catccggaac tacctggcct ggtatcagca gaaacccggc      180

aaggtgccca agctgctgat ctacgccacc tccaccctgc agtccggcgt gccctcccgg      240

ttctctggct ccagatccgg caccgagttc accctgacca tctccagcct gcaccccgag      300

gacttcgcca cctactactg ccagcaggtg gaccggttcc cctacacctt cggccagggg      360

accaaggtgg aactcaagcg gaccgtggcc gctccttccg tgttcatctt ccctccctcc      420

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      540

tccgtcaccg agcaggactc caaggactct acctactccc tgtcctccac cctgaccctg      600

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      660

tcctctcccg tgaccaagtc cttcaaccgg ggcgagtgct ga                         702


<210>  45
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C12D light chain

<400>  45
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcactccgag       60

atccagatga cccagtcccc ctccagcctg tccgcctctg tgggcgacag agtgaccatc      120

acctgtcggg cctcccaggg catctccagc tggctggcct ggtatcagca gaagcccggc      180

aaggccccca agctgctgat ctacgccgcc agctccctgc agtccggcgt gccatccaga      240

ttctccggct ccggcagcgg caccgagttc accctgacca tctccagcct gcagcccgac      300

gacttcgcca cctactactg ccagaagctg tcctcctacc cctacacctt cggcggaggg      360

accaaggtgg aactcaagcg gaccgtggcc gctccttccg tgttcatctt ccctccctcc      420

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      540

tccgtcaccg agcaggactc caaggactct acctactccc tgtcctccac cctgaccctg      600

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      660

tcctctcccg tgaccaagtc cttcaaccgg ggcgagtgct ga                         702


<210>  46
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C12E light chain

<400>  46
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcgt gcactccgag       60

attgtgctga ctcagtcccc ctccagcctg tccgcctccg tgggcgacag agtgaccatc      120

acctgtcggg cctcccaggg catctccaac tacctggcct ggtatcagca gaaacccggc      180

aaggtgccca agctgctgat ctacgccgcc tccaccctgc agtccggcgt gccatccaga      240

ttctccggct ccggcagcgg cacccacttc accctgacca tctccagcct gcagcccgag      300

gacgtggcca cctactactg ccagaagtgc aactccgccc cctacacctt cggccagggg      360

accaaggtgg aactcaagcg gaccgtggcc gctccttccg tgttcatctt ccctccctcc      420

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      540

tccgtcaccg agcaggactc caaggactct acctactccc tgtcctccac cctgaccctg      600

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      660

tcctctcccg tgaccaagtc cttcaaccgg ggcgagtgct ga                         702


<210>  47
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain Vh region of 1F7

<400>  47
gaggtccagc tggtacagtc tggtggagcc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct gtatcatatg atggaagtaa taaatactat      180

gcagacttcg tgaaggggcg attcaccatc tccagagaca atcccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgatgac acggccgtat attactgtgc ccgcagaggt      300

ggtcttgata tctggggcca agggaccacg gtcaccgtct caagcgcctc caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtccacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtag tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgcggcc      660

gca                                                                    663


<210>  48
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F7 light chain

<400>  48
ctgactcagc cacccccagc gtctgggacc cccgggcaga gggtcaccat ctcttgttct       60

ggaagcagct ccaacatcgg aagtaatact gtaaactggt accagcaact cccaggaacg      120

gcccccaaac tcctcattta tggtaatgat cagcggccct caggggtccc tgaccgattc      180

tctgcctcca agtctggcac ctcagcctcc ctggccatca gtgggctcca gtctgaggat      240

gaggctcatt attattgtgc agcatgggat ggcagtctga atggtggtgt gatattcggc      300

ggagggacca aggtgaccgt cctgggtcag cccaaggctg ccccctcggt cactctgttc      360

ccaccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccaaaccctc caaacagagc aacaacaagt acgcggccag cagctacctg      540

agcctgacgc ccgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt cataataa                   648


<210>  49
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.1 light chain

<400>  49
gtgacgcagc cgccctcagc gtctgggacc cccgggcaga gggtcaccat ctcttgttct       60

gggagcagct ccaacatcgg aactaatcct gtaaactggt accagcagct cccaggaacg      120

gcccccaaac tcctcatcta tactactgat cagcggccct caggggtccc tgaccgcttc      180

tctggctcca agtctggcac ctcagcctcc ctggccatca gtgggctcca gtctgaggat      240

gaggctgatt attactgtgc agcatgggat gacagcctga gtggccttta tgtcttcggg      300

actgggacca aggtcaccgt cctcggtcag cccaaggcca accccactgt cactctgttc      360

ccgccctcct ctgaggagct ccaagccaac aaggccacac tagtgtgtct gatcagtgac      420

ttctacccgg gagctgtgac agtggcctgg aaggcagatg gcagccccgt caaggcggga      480

gtggagacca ccaaaccctc caaacagagc aacaacaagt acgcggccag cagctacctg      540

agcctgacgc ccgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct gcagaatgct cttaataa                   648


<210>  50
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.2 light chain

<400>  50
atgacccaca ctccattgtc tctgtccgtc acccctggac agccggcctc catctcctgc       60

aagtctagtc agagtctctt gcatagtgat ggaaagacct atttgtattg gtacctgcag      120

aggccaggcc agtctccaca gcccctgatc tatgaagttt ccaaccggtt ctctggagtg      180

ccagataggt tcagtggcag cgggtcaggg acagatttca cactgaaaat cagccgggtg      240

gaggctgagg atgtcggggt ttattactgc atgcaaagtc tacaactctg gacgttcggc      300

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaata a               651


<210>  51
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.3 light chain

<400>  51
atgactcagt ctccactctc cctgcccgtc acccttggac agccggcctc catctcctgc       60

aggtctagtc aaagcctcat acacagtgat ggaaacacgt acttggattg gtttcagcag      120

aggccaggcc aatctccaag gcgcctaatt tataaggttt ctaaccggga ctctggggtc      180

ccagacagat tcagcggcag tgggtccggc actgatttca cactgagaat cagcagggtg      240

gaggctgagg atattggggt gtattactgc atgcaagcta cacactggcc tcggacgttc      300

ggccagggga ccaaggtgga aatcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta ataa            654


<210>  52
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.4 light chain

<400>  52
atgactcagt ctccactctc cctgcccgtc acccttggac agccggcctc catctcctgc       60

aggtctagtc aaagcctcgt agacagtgct ggaaacacct tcttgcattg gtttcaccag      120

aggccaggcc aatctccaag gcgcctaatt tataaggttt ctaaccggga ctctggggtc      180

ccagacagat tcagcggcag tgggtcaggc actgatttca cactgaaaat cagcagggtg      240

gaggctgagg atgttggggt ttattactgt atgcaaggta cacactggcc ccggacgttc      300

ggccaaggga ccaaggtgga aatcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta ataa            654


<210>  53
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.5 light chain

<400>  53
ctgactcagt ctccactctc cctgcccgtc acccttggac agccggcctc catctcctgc       60

aagtctagtc aaagcctcgt agacagtgat ggaaacacct acttgaattg gtttcagcag      120

aggccaggcc aatctccaag gcgcctaatt tataaggttt ctaaccggga ctctggggtc      180

ccagacagat tcagcggcag tgggtcaggc actgatttca cactgaaaat cagcagggtg      240

gaggctgagg atgttggggt ttattactgc atgcaaggta cacactggcc tcggacgttc      300

ggccaaggga ccaaggtgga aatcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta ataa            654


<210>  54
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.7 light chain

<400>  54
atgactcagt ctccactctc cctgcccgtc acccttggac agccggcctc catctcctgc       60

aggtctagtc aaagcctcgt acacagtgat ggaaacatgt acttgaattg gtttcagcag      120

aggccaggcc aatctccaag gcgcctaatt tataaggttt ctaaccggga ctctggggtc      180

ccagacagat tcagcggcag tgggtcaggc acagatttta cactgaaaat cagcagagtg      240

gaggctgagg atgttggggt ttattactgc atgcaagcta cacagcccac gtggacgttc      300

ggccaaggga ccaagctgga gatcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca      600

tcagggcctg agctcgcccg tcacaaagag cttcaacagg ggagagtgtt aataaggcgc      660

gccaattcta tttcaaggag acagtcataa tga                                   693


<210>  55
<211>  677
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.8 light chain

<400>  55
atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc       60

caggcgagtc aggacattag caactattta aattggtatc agcagaaacc agggaaagcc      120

cctaagctcc tgatctacga tgcatccaat ttggaaacag gggtcccatc aaggttcagt      180

ggaagtggat ctgggacaga ttttactttc accatcagca gcctgcaacc tgacgatttt      240

gcaacttact actgtcaaca gacttacagt tggcctcgga cttttggcca ggggaccaag      300

ctggagatca aacgaactgt ggctgcacca tctgtcttca tcttcccgcc atctgatgag      360

cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag      420

gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc      480

acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa      540

gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg      600

cccgtcacaa agagcttcaa caggggagag tgttaataag gcgcgccaat tctatttcaa      660

ggagacagtc ataatga                                                     677


<210>  56
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.9 light chain

<400>  56
atgacccagt ctccatcctc cctgtccgca tctgtaggac acccagtcac catcacttgc       60

cgggcaagtc aaagccttat cagctattta aattggtatc accagaaacc agggaaagcc      120

cctaagctcc tgatctatgc ggcatccatt ttgcaaagtg gggtcccatc aaggttcagt      180

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaaaatttt      240

gcaagttact actgtcaaca taccgacagt ttccctcgga cgttcggcca cgggaccaag      300

gtggaaatca aacgaactgt ggctgcacca tctgtcttca tcttcccgcc atctgatgac      360

cagttgaaat ctggaactgc ctccgttgtg tgcctgctga ataacttcta tcccaaaaag      420

gccaaagtac aatggaaggt ggataacgcc ctcgagtcgg gtaactccca ggagagtgtc      480

acagagcagg acgtcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa      540

gccggactac gagaaaccaa agtctacgcc tgcgaagtca cccatctgcg aactgagctc      600

tcccgtcaca aagagcttca caggggagag tgttaataa                             639


<210>  57
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.10 light chain

<400>  57
ctgactcagc ccccctcagc gtctgggacc cccgggcagg gtgtcaccat ctcctgtcgt       60

ggaagcacct ccaacatcgg aaataatgtt gttaattggt atcaacatgt cccgggatcg      120

gcccccaaac tcctcatctg gagtaatatt cagcggccct cagggattcc tgaccgattc      180

tctggctcca agtctggcac ctcagcctcc ctggccatca gtggacttca gtctgaagat      240

gaggctgttt attactgtgc agtctgggat gacggcctgg ctggttgggt gttcggcgga      300

gggaccacgg tgaccgtcct aagtcagccc aaggctgccc cctcggtcac tctgttcccg      360

ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      420

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctacctgagc      540

ctgacgcctg agcagtggaa gtcccacaaa agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctaca gaatgttcat aataa                      645


<210>  58
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.12 light chain

<400>  58
atgactcagg cccctgttgt gtcggtggcc ttggaacaaa cagtcaggat cacatgccaa       60

ggagacagcc tagcaatcta ttatgatttc tggtaccagc acaagccagg acaggcccct      120

gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccccaccg attctctggc      180

tccagctcat gaaacacaga ttccttgacc atcactgggg ctcaggcgga agatgaggct      240

gactattact gtaactcccg ggacagcagt ggtaaccatt gggtgttcgg cggagggacc      300

aacctgaccg tcctaggtca acccaaggct gccccctcgg ccattctgtt cccgccctcc      360

tctgaggagc ttcaaactaa cacggctaca tgggtgtgtc tcatatttga cttctacccg      420

ggagctgtaa cagtggccgg gaatgcagat ggcaaccccg tcaacgccgg agtggatacc      480

accaaaccct actgccagaa caacaactac tacgcggcca gcacctacct gatcatgacg      540

cctgaccagt ggaaatccca cttcagctac agctaactcg tcacgcatga agggagctcc      600

gtggacaaga aaatggcccc tgcagaatgc tcttaataa                             639


<210>  59
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hFab4.18 light chain

<400>  59
ctgactcagt ctccactctc cctgcccgtc acccttggac agccggcctc catctcctgc       60

aagtctaatc aaagcctcgt acacagtgat ggaaacacct acttgaattg gtttcagcag      120

aggccaggcc aatctccaag gcgcctaatc tataaggttt ctaaccggga ctctggggtc      180

ccagacagat tcagcggcag tgggtcaggc actgatttca cactgaaaat caacagggtg      240

gaggctgagg atgttggggt ttattactgc atgcaaggta cacagtggcc tcggactttt      300

ggccagggga ccaagctgga catcaaacga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca cagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaaa ctacaagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga cctcgcccgt cacaaagagc ttcaacaagg gagagtgtta ataa            654


