                         SEQUENCE LISTING

<110>  Gossamer Bio Services, Inc.
 
<120>  OXIME COMPOUNDS USEFUL AS T-CELL ACTIVATORS

<130>  360474.401WO

<150>  US 63/041,771
<151>  2020-06-19

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  735
<212>  PRT
<213>  Homo sapiens

<300>
<308>  RefSeq | NP_958852.1
<309>  2004-09-14
<313>  (1)..(735)

<400>  1

Met Ala Lys Glu Arg Gly Leu Ile Ser Pro Ser Asp Phe Ala Gln Leu 
1               5                   10                  15      


Gln Lys Tyr Met Glu Tyr Ser Thr Lys Lys Val Ser Asp Val Leu Lys 
            20                  25                  30          


Leu Phe Glu Asp Gly Glu Met Ala Lys Tyr Val Gln Gly Asp Ala Ile 
        35                  40                  45              


Gly Tyr Glu Gly Phe Gln Gln Phe Leu Lys Ile Tyr Leu Glu Val Asp 
    50                  55                  60                  


Asn Val Pro Arg His Leu Ser Leu Ala Leu Phe Gln Ser Phe Glu Thr 
65                  70                  75                  80  


Gly His Cys Leu Asn Glu Thr Asn Val Thr Lys Asp Val Val Cys Leu 
                85                  90                  95      


Asn Asp Val Ser Cys Tyr Phe Ser Leu Leu Glu Gly Gly Arg Pro Glu 
            100                 105                 110         


Asp Lys Leu Glu Phe Thr Phe Lys Leu Tyr Asp Thr Asp Arg Asn Gly 
        115                 120                 125             


Ile Leu Asp Ser Ser Glu Val Asp Lys Ile Ile Leu Gln Met Met Arg 
    130                 135                 140                 


Val Ala Glu Tyr Leu Asp Trp Asp Val Ser Glu Leu Arg Pro Ile Leu 
145                 150                 155                 160 


Gln Glu Met Met Lys Glu Ile Asp Tyr Asp Gly Ser Gly Ser Val Ser 
                165                 170                 175     


Gln Ala Glu Trp Val Arg Ala Gly Ala Thr Thr Val Pro Leu Leu Val 
            180                 185                 190         


Leu Leu Gly Leu Glu Met Thr Leu Lys Asp Asp Gly Gln His Met Trp 
        195                 200                 205             


Arg Pro Lys Arg Phe Pro Arg Pro Val Tyr Cys Asn Leu Cys Glu Ser 
    210                 215                 220                 


Ser Ile Gly Leu Gly Lys Gln Gly Leu Ser Cys Asn Leu Cys Lys Tyr 
225                 230                 235                 240 


Thr Val His Asp Gln Cys Ala Met Lys Ala Leu Pro Cys Glu Val Ser 
                245                 250                 255     


Thr Tyr Ala Lys Ser Arg Lys Asp Ile Gly Val Gln Ser His Val Trp 
            260                 265                 270         


Val Arg Gly Gly Cys Glu Ser Gly Arg Cys Asp Arg Cys Gln Lys Lys 
        275                 280                 285             


Ile Arg Ile Tyr His Ser Leu Thr Gly Leu His Cys Val Trp Cys His 
    290                 295                 300                 


Leu Glu Ile His Asp Asp Cys Leu Gln Ala Val Gly His Glu Cys Asp 
305                 310                 315                 320 


Cys Gly Leu Leu Arg Asp His Ile Leu Pro Pro Ser Ser Ile Tyr Pro 
                325                 330                 335     


Ser Val Leu Ala Ser Gly Pro Asp Arg Lys Asn Ser Lys Thr Ser Gln 
            340                 345                 350         


Lys Thr Met Asp Asp Leu Asn Leu Ser Thr Ser Glu Ala Leu Arg Ile 
        355                 360                 365             


Asp Pro Val Pro Asn Thr His Pro Leu Leu Val Phe Val Asn Pro Lys 
    370                 375                 380                 


Ser Gly Gly Lys Gln Gly Gln Arg Val Leu Trp Lys Phe Gln Tyr Ile 
385                 390                 395                 400 


Leu Asn Pro Arg Gln Val Phe Asn Leu Leu Lys Asp Gly Pro Glu Ile 
                405                 410                 415     


Gly Leu Arg Leu Phe Lys Asp Val Pro Asp Ser Arg Ile Leu Val Cys 
            420                 425                 430         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Glu Thr Ile Asp Lys Ala 
        435                 440                 445             


Asn Leu Pro Val Leu Pro Pro Val Ala Val Leu Pro Leu Gly Thr Gly 
    450                 455                 460                 


Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gln 
465                 470                 475                 480 


Asn Leu Ala Lys Ile Leu Lys Asp Leu Glu Met Ser Lys Val Val His 
                485                 490                 495     


Met Asp Arg Trp Ser Val Glu Val Ile Pro Gln Gln Thr Glu Glu Lys 
            500                 505                 510         


Ser Asp Pro Val Pro Phe Gln Ile Ile Asn Asn Tyr Phe Ser Ile Gly 
        515                 520                 525             


Val Asp Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys Tyr 
    530                 535                 540                 


Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu 
545                 550                 555                 560 


Phe Ala Thr Ser Glu Ser Ile Phe Ser Thr Cys Lys Lys Leu Glu Glu 
                565                 570                 575     


Ser Leu Thr Val Glu Ile Cys Gly Lys Pro Leu Asp Leu Ser Asn Leu 
            580                 585                 590         


Ser Leu Glu Gly Ile Ala Val Leu Asn Ile Pro Ser Met His Gly Gly 
        595                 600                 605             


Ser Asn Leu Trp Gly Asp Thr Arg Arg Pro His Gly Asp Ile Tyr Gly 
    610                 615                 620                 


Ile Asn Gln Ala Leu Gly Ala Thr Ala Lys Val Ile Thr Asp Pro Asp 
625                 630                 635                 640 


Ile Leu Lys Thr Cys Val Pro Asp Leu Ser Asp Lys Arg Leu Glu Val 
                645                 650                 655     


Val Gly Leu Glu Gly Ala Ile Glu Met Gly Gln Ile Tyr Thr Lys Leu 
            660                 665                 670         


Lys Asn Ala Gly Arg Arg Leu Ala Lys Cys Ser Glu Ile Thr Phe His 
        675                 680                 685             


Thr Thr Lys Thr Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln 
    690                 695                 700                 


Thr Pro Cys Thr Ile Lys Ile Thr His Lys Asn Gln Met Pro Met Leu 
705                 710                 715                 720 


Met Gly Pro Pro Pro Arg Ser Thr Asn Phe Phe Gly Phe Leu Ser 
                725                 730                 735 


<210>  2
<211>  929
<212>  PRT
<213>  Homo sapiens

<300>
<308>  RefSeq | NP_003637.2
<309>  2004-09-14
<313>  (1)..(929)

<400>  2

Met Glu Pro Arg Asp Gly Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu 
1               5                   10                  15      


Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Gly Pro Glu 
            20                  25                  30          


Pro Asp Lys Ala Pro Arg Arg Leu Asn Lys Arg Arg Phe Pro Gly Leu 
        35                  40                  45              


Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His 
    50                  55                  60                  


Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu 
65                  70                  75                  80  


Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly 
                85                  90                  95      


Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val 
            100                 105                 110         


Gly Glu Gln Tyr Cys Val Ala Arg Met Leu Gln Lys Ser Val Ser Arg 
        115                 120                 125             


Arg Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu 
    130                 135                 140                 


Gln Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser 
145                 150                 155                 160 


Gly Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val 
                165                 170                 175     


His Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe 
            180                 185                 190         


Gln Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys 
        195                 200                 205             


Ser Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu 
    210                 215                 220                 


Gln Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val 
225                 230                 235                 240 


Ile Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu 
                245                 250                 255     


Lys Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser 
            260                 265                 270         


Lys Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro 
        275                 280                 285             


Thr Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys 
    290                 295                 300                 


Ser Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr 
305                 310                 315                 320 


Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu 
                325                 330                 335     


Ala Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys 
            340                 345                 350         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu 
        355                 360                 365             


Arg Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly 
    370                 375                 380                 


Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu 
385                 390                 395                 400 


Pro Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln 
                405                 410                 415     


Leu Asp Arg Trp Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro 
            420                 425                 430         


Glu Asp Arg Asp Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe 
        435                 440                 445             


Asn Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe 
    450                 455                 460                 


His Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg 
465                 470                 475                 480 


Asn Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly 
                485                 490                 495     


Ser Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met 
            500                 505                 510         


Asp Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe 
        515                 520                 525             


Leu Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro 
    530                 535                 540                 


Gly Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu 
545                 550                 555                 560 


Glu Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly 
                565                 570                 575     


Gly His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr 
            580                 585                 590         


Ser Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala 
        595                 600                 605             


Ala Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln 
    610                 615                 620                 


Lys Ala Lys Arg Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro 
625                 630                 635                 640 


Val Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp 
                645                 650                 655     


Tyr Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val 
            660                 665                 670         


Pro Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys 
        675                 680                 685             


Arg Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala 
    690                 695                 700                 


Lys Ser Pro Thr Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp 
705                 710                 715                 720 


Ala Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His 
                725                 730                 735     


Leu Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp 
            740                 745                 750         


Pro Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr 
        755                 760                 765             


Ser Pro Leu Pro Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln 
    770                 775                 780                 


Gly Asp Ala Ala Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys 
785                 790                 795                 800 


Arg Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp 
                805                 810                 815     


Leu Met His Arg Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val 
            820                 825                 830         


Ser Thr Gly Ser Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro 
        835                 840                 845             


Pro Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His 
    850                 855                 860                 


Gln Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu 
865                 870                 875                 880 


Ala Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg 
                885                 890                 895     


Gln Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu 
            900                 905                 910         


Asn Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala 
        915                 920                 925             


Val 
    


<210>  3
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-DGKA fusion protein


<220>
<221>  GST-DGKA
<222>  (1)..(977)
<223>  Full length human DGKA expressed as N-terminal GST-fusion protein

<400>  3

Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ala Met Gly Ser Gly Ile Gln Arg Pro Thr 
225                 230                 235                 240 


Ser Thr Met Ala Lys Glu Arg Gly Leu Ile Ser Pro Ser Asp Phe Ala 
                245                 250                 255     


Gln Leu Gln Lys Tyr Met Glu Tyr Ser Thr Lys Lys Val Ser Asp Val 
            260                 265                 270         


Leu Lys Leu Phe Glu Asp Gly Glu Met Ala Lys Tyr Val Gln Gly Asp 
        275                 280                 285             


Ala Ile Gly Tyr Glu Gly Phe Gln Gln Phe Leu Lys Ile Tyr Leu Glu 
    290                 295                 300                 


Val Asp Asn Val Pro Arg His Leu Ser Leu Ala Leu Phe Gln Ser Phe 
305                 310                 315                 320 


Glu Thr Gly His Cys Leu Asn Glu Thr Asn Val Thr Lys Asp Val Val 
                325                 330                 335     


Cys Leu Asn Asp Val Ser Cys Tyr Phe Ser Leu Leu Glu Gly Gly Arg 
            340                 345                 350         


Pro Glu Asp Lys Leu Glu Phe Thr Phe Lys Leu Tyr Asp Thr Asp Arg 
        355                 360                 365             


Asn Gly Ile Leu Asp Ser Ser Glu Val Asp Lys Ile Ile Leu Gln Met 
    370                 375                 380                 


Met Arg Val Ala Glu Tyr Leu Asp Trp Asp Val Ser Glu Leu Arg Pro 
385                 390                 395                 400 


Ile Leu Gln Glu Met Met Lys Glu Ile Asp Tyr Asp Gly Ser Gly Ser 
                405                 410                 415     


Val Ser Gln Ala Glu Trp Val Arg Ala Gly Ala Thr Thr Val Pro Leu 
            420                 425                 430         


Leu Val Leu Leu Gly Leu Glu Met Thr Leu Lys Asp Asp Gly Gln His 
        435                 440                 445             


Met Trp Arg Pro Lys Arg Phe Pro Arg Pro Val Tyr Cys Asn Leu Cys 
    450                 455                 460                 


Glu Ser Ser Ile Gly Leu Gly Lys Gln Gly Leu Ser Cys Asn Leu Cys 
465                 470                 475                 480 


Lys Tyr Thr Val His Asp Gln Cys Ala Met Lys Ala Leu Pro Cys Glu 
                485                 490                 495     


Val Ser Thr Tyr Ala Lys Ser Arg Lys Asp Ile Gly Val Gln Ser His 
            500                 505                 510         


Val Trp Val Arg Gly Gly Cys Glu Ser Gly Arg Cys Asp Arg Cys Gln 
        515                 520                 525             


Lys Lys Ile Arg Ile Tyr His Ser Leu Thr Gly Leu His Cys Val Trp 
    530                 535                 540                 


Cys His Leu Glu Ile His Asp Asp Cys Leu Gln Ala Val Gly His Glu 
545                 550                 555                 560 


Cys Asp Cys Gly Leu Leu Arg Asp His Ile Leu Pro Pro Ser Ser Ile 
                565                 570                 575     


Tyr Pro Ser Val Leu Ala Ser Gly Pro Asp Arg Lys Asn Ser Lys Thr 
            580                 585                 590         


Ser Gln Lys Thr Met Asp Asp Leu Asn Leu Ser Thr Ser Glu Ala Leu 
        595                 600                 605             


Arg Ile Asp Pro Val Pro Asn Thr His Pro Leu Leu Val Phe Val Asn 
    610                 615                 620                 


Pro Lys Ser Gly Gly Lys Gln Gly Gln Arg Val Leu Trp Lys Phe Gln 
625                 630                 635                 640 


Tyr Ile Leu Asn Pro Arg Gln Val Phe Asn Leu Leu Lys Asp Gly Pro 
                645                 650                 655     


Glu Ile Gly Leu Arg Leu Phe Lys Asp Val Pro Asp Ser Arg Ile Leu 
            660                 665                 670         


Val Cys Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Glu Thr Ile Asp 
        675                 680                 685             


Lys Ala Asn Leu Pro Val Leu Pro Pro Val Ala Val Leu Pro Leu Gly 
    690                 695                 700                 


Thr Gly Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu 
705                 710                 715                 720 


Gly Gln Asn Leu Ala Lys Ile Leu Lys Asp Leu Glu Met Ser Lys Val 
                725                 730                 735     


Val His Met Asp Arg Trp Ser Val Glu Val Ile Pro Gln Gln Thr Glu 
            740                 745                 750         


Glu Lys Ser Asp Pro Val Pro Phe Gln Ile Ile Asn Asn Tyr Phe Ser 
        755                 760                 765             


Ile Gly Val Asp Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu 
    770                 775                 780                 


Lys Tyr Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr 
785                 790                 795                 800 


Phe Glu Phe Ala Thr Ser Glu Ser Ile Phe Ser Thr Cys Lys Lys Leu 
                805                 810                 815     


Glu Glu Ser Leu Thr Val Glu Ile Cys Gly Lys Pro Leu Asp Leu Ser 
            820                 825                 830         


Asn Leu Ser Leu Glu Gly Ile Ala Val Leu Asn Ile Pro Ser Met His 
        835                 840                 845             


Gly Gly Ser Asn Leu Trp Gly Asp Thr Arg Arg Pro His Gly Asp Ile 
    850                 855                 860                 


Tyr Gly Ile Asn Gln Ala Leu Gly Ala Thr Ala Lys Val Ile Thr Asp 
865                 870                 875                 880 


Pro Asp Ile Leu Lys Thr Cys Val Pro Asp Leu Ser Asp Lys Arg Leu 
                885                 890                 895     


Glu Val Val Gly Leu Glu Gly Ala Ile Glu Met Gly Gln Ile Tyr Thr 
            900                 905                 910         


Lys Leu Lys Asn Ala Gly Arg Arg Leu Ala Lys Cys Ser Glu Ile Thr 
        915                 920                 925             


Phe His Thr Thr Lys Thr Leu Pro Met Gln Ile Asp Gly Glu Pro Trp 
    930                 935                 940                 


Met Gln Thr Pro Cys Thr Ile Lys Ile Thr His Lys Asn Gln Met Pro 
945                 950                 955                 960 


Met Leu Met Gly Pro Pro Pro Arg Ser Thr Asn Phe Phe Gly Phe Leu 
                965                 970                 975     


Ser 
    


<210>  4
<211>  1171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST-DGKZ fusion protien


<220>
<221>  GST-DKGZ
<222>  (1)..(1171)
<223>  Full length human DGKZ expressed as N-terminal GST-fusion protein

<400>  4

Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Leu Gly Ala Met Gly Ser Gly Ile Gln Arg Pro Thr 
225                 230                 235                 240 


Ser Thr Met Glu Pro Arg Asp Gly Ser Pro Glu Ala Arg Ser Ser Asp 
                245                 250                 255     


Ser Glu Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Gly 
            260                 265                 270         


Pro Glu Pro Asp Lys Ala Pro Arg Arg Leu Asn Lys Arg Arg Phe Pro 
        275                 280                 285             


Gly Leu Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu 
    290                 295                 300                 


Gln His Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu 
305                 310                 315                 320 


Ser Glu Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr 
                325                 330                 335     


Tyr Gly Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys 
            340                 345                 350         


Tyr Val Gly Glu Gln Tyr Cys Val Ala Arg Met Leu Gln Lys Ser Val 
        355                 360                 365             


Ser Arg Arg Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys 
    370                 375                 380                 


Ile Glu Gln Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg 
385                 390                 395                 400 


Glu Ser Gly Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His 
                405                 410                 415     


Trp Val His Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys 
            420                 425                 430         


Gly Phe Gln Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile 
        435                 440                 445             


Ser Cys Ser Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe 
    450                 455                 460                 


Met Leu Gln Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala 
465                 470                 475                 480 


Val Val Ile Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn 
                485                 490                 495     


Thr Leu Lys Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys 
            500                 505                 510         


Ser Ser Lys Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile 
        515                 520                 525             


Arg Pro Thr Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn 
    530                 535                 540                 


Pro Lys Ser Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu 
545                 550                 555                 560 


Trp Tyr Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro 
                565                 570                 575     


Lys Glu Ala Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu 
            580                 585                 590         


Ala Cys Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp 
        595                 600                 605             


Gln Leu Arg Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly 
    610                 615                 620                 


Thr Gly Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr 
625                 630                 635                 640 


Asp Glu Pro Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val 
                645                 650                 655     


Val Gln Leu Asp Arg Trp Asp Leu His Ala Glu Pro Asn Pro Glu Ala 
            660                 665                 670         


Gly Pro Glu Asp Arg Asp Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp 
        675                 680                 685             


Val Phe Asn Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu 
    690                 695                 700                 


Glu Phe His Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg 
705                 710                 715                 720 


Phe Arg Asn Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu 
                725                 730                 735     


Met Gly Ser Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp 
            740                 745                 750         


Gly Met Asp Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Val 
        755                 760                 765             


Val Phe Leu Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly 
    770                 775                 780                 


His Pro Gly Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly 
785                 790                 795                 800 


Tyr Leu Glu Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln 
                805                 810                 815     


Val Gly Gly His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Val Leu 
            820                 825                 830         


Thr Thr Ser Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys 
        835                 840                 845             


Leu Ala Ala Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met 
    850                 855                 860                 


Val Gln Lys Ala Lys Arg Arg Ser Ala Ala Pro Leu His Ser Asp Gln 
865                 870                 875                 880 


Gln Pro Val Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met 
                885                 890                 895     


His Asp Tyr Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala 
            900                 905                 910         


Ser Val Pro Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu 
        915                 920                 925             


Leu Cys Arg Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala 
    930                 935                 940                 


Gly Ala Lys Ser Pro Thr Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe 
945                 950                 955                 960 


Leu Asp Ala Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln 
                965                 970                 975     


Glu His Leu Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile 
            980                 985                 990         


Leu Asp Pro Glu Leu Leu Gly Ala  Ser Ala Arg Pro Asp  Leu Pro Thr 
        995                 1000                 1005             


Pro Thr  Ser Pro Leu Pro Thr  Ser Pro Cys Ser Pro  Thr Pro Arg 
    1010                 1015                 1020             


Ser Leu  Gln Gly Asp Ala Ala  Pro Pro Gln Gly Glu  Glu Leu Ile 
    1025                 1030                 1035             


Glu Ala  Ala Lys Arg Asn Asp  Phe Cys Lys Leu Gln  Glu Leu His 
    1040                 1045                 1050             


Arg Ala  Gly Gly Asp Leu Met  His Arg Asp Glu Gln  Ser Arg Thr 
    1055                 1060                 1065             


Leu Leu  His His Ala Val Ser  Thr Gly Ser Lys Asp  Val Val Arg 
    1070                 1075                 1080             


Tyr Leu  Leu Asp His Ala Pro  Pro Glu Ile Leu Asp  Ala Val Glu 
    1085                 1090                 1095             


Glu Asn  Gly Glu Thr Cys Leu  His Gln Ala Ala Ala  Leu Gly Gln 
    1100                 1105                 1110             


Arg Thr  Ile Cys His Tyr Ile  Val Glu Ala Gly Ala  Ser Leu Met 
    1115                 1120                 1125             


Lys Thr  Asp Gln Gln Gly Asp  Thr Pro Arg Gln Arg  Ala Glu Lys 
    1130                 1135                 1140             


Ala Gln  Asp Thr Glu Leu Ala  Ala Tyr Leu Glu Asn  Arg Gln His 
    1145                 1150                 1155             


Tyr Gln  Met Ile Gln Arg Glu  Asp Gln Glu Thr Ala  Val 
    1160                 1165                 1170     


