                         SEQUENCE LISTING

<110>  Halo-Bio RNAi Therapeutics, Inc.
       Hauser, Todd M
 
<120>  METHODS AND COMPOSITIONS OF RNA NANOSTRUCTURES FOR REPLICATION 
       AND SUBGENOMIC EXPRESSION BY RNA-DIRECTED RNA POLYMERASE

<130>  US63/041,890

<150>  US63/041,890
<151>  2020-06-20

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  29903
<212>  RNA
<213>  SARS-2 coronavirus


<220>
<221>  5'UTR
<222>  (1)..(265)

<220>
<221>  promoter
<222>  (68)..(75)
<223>  Leader TRS or TRS-L

<220>
<221>  CDS
<222>  (11843)..(12091)
<223>  RdRp co-factor gene nsp7, works in complex with nsp12

<220>
<221>  CDS
<222>  (12092)..(12685)
<223>  RdRp co-factor gene nsp8, works in complex with nsp12

<220>
<221>  CDS
<222>  (13442)..(16237)
<223>  RdRp gene nsp12

<220>
<221>  CDS
<222>  (18040)..(19620)
<223>  RdRp proof-reading gene nsp14, works in complex with nsp12

<220>
<221>  promoter
<222>  (21554)..(21561)
<223>  Body TRS (B-TRS)

<220>
<221>  misc_RNA
<222>  (21556)..(21561)
<223>  Conserved Sequence (CS)

<220>
<221>  promoter
<222>  (25385)..(25390)
<223>  Example of other Body TRS (B-TRS)

<220>
<221>  promoter
<222>  (26237)..(26242)
<223>  TRS (B-TRS)

<220>
<221>  promoter
<222>  (26473)..(26478)
<223>  TRS (B-TRS)

<220>
<221>  promoter
<222>  (27041)..(27046)
<223>  TRS (B-TRS)

<220>
<221>  promoter
<222>  (27886)..(27893)
<223>  TRS (B-TRS)

<220>
<221>  3'UTR
<222>  (29675)..(29903)

<400>  1
auuaaagguu uauaccuucc cagguaacaa accaaccaac uuucgaucuc uuguagaucu       60

guucucuaaa cgaacuuuaa aaucugugug gcugucacuc ggcugcaugc uuagugcacu      120

cacgcaguau aauuaauaac uaauuacugu cguugacagg acacgaguaa cucgucuauc      180

uucugcaggc ugcuuacggu uucguccgug uugcagccga ucaucagcac aucuagguuu      240

cguccgggug ugaccgaaag guaagaugga gagccuuguc ccugguuuca acgagaaaac      300

acacguccaa cucaguuugc cuguuuuaca gguucgcgac gugcucguac guggcuuugg      360

agacuccgug gaggaggucu uaucagaggc acgucaacau cuuaaagaug gcacuugugg      420

cuuaguagaa guugaaaaag gcguuuugcc ucaacuugaa cagcccuaug uguucaucaa      480

acguucggau gcucgaacug caccucaugg ucauguuaug guugagcugg uagcagaacu      540

cgaaggcauu caguacgguc guagugguga gacacuuggu guccuugucc cucauguggg      600

cgaaauacca guggcuuacc gcaagguucu ucuucguaag aacgguaaua aaggagcugg      660

uggccauagu uacggcgccg aucuaaaguc auuugacuua ggcgacgagc uuggcacuga      720

uccuuaugaa gauuuucaag aaaacuggaa cacuaaacau agcaguggug uuacccguga      780

acucaugcgu gagcuuaacg gaggggcaua cacucgcuau gucgauaaca acuucugugg      840

cccugauggc uacccucuug agugcauuaa agaccuucua gcacgugcug guaaagcuuc      900

augcacuuug uccgaacaac uggacuuuau ugacacuaag agggguguau acugcugccg      960

ugaacaugag caugaaauug cuugguacac ggaacguucu gaaaagagcu augaauugca     1020

gacaccuuuu gaaauuaaau uggcaaagaa auuugacacc uucaaugggg aauguccaaa     1080

uuuuguauuu cccuuaaauu ccauaaucaa gacuauucaa ccaaggguug aaaagaaaaa     1140

gcuugauggc uuuaugggua gaauucgauc ugucuaucca guugcgucac caaaugaaug     1200

caaccaaaug ugccuuucaa cucucaugaa gugugaucau uguggugaaa cuucauggca     1260

gacgggcgau uuuguuaaag ccacuugcga auuuuguggc acugagaauu ugacuaaaga     1320

aggugccacu acuugugguu acuuacccca aaaugcuguu guuaaaauuu auuguccagc     1380

augucacaau ucagaaguag gaccugagca uagucuugcc gaauaccaua augaaucugg     1440

cuugaaaacc auucuucgua aggguggucg cacuauugcc uuuggaggcu guguguucuc     1500

uuauguuggu ugccauaaca agugugccua uuggguucca cgugcuagcg cuaacauagg     1560

uuguaaccau acagguguug uuggagaagg uuccgaaggu cuuaaugaca accuucuuga     1620

aauacuccaa aaagagaaag ucaacaucaa uauuguuggu gacuuuaaac uuaaugaaga     1680

gaucgccauu auuuuggcau cuuuuucugc uuccacaagu gcuuuugugg aaacugugaa     1740

agguuuggau uauaaagcau ucaaacaaau uguugaaucc ugugguaauu uuaaaguuac     1800

aaaaggaaaa gcuaaaaaag gugccuggaa uauuggugaa cagaaaucaa uacugagucc     1860

ucuuuaugca uuugcaucag aggcugcucg uguuguacga ucaauuuucu cccgcacucu     1920

ugaaacugcu caaaauucug ugcguguuuu acagaaggcc gcuauaacaa uacuagaugg     1980

aauuucacag uauucacuga gacucauuga ugcuaugaug uucacaucug auuuggcuac     2040

uaacaaucua guuguaaugg ccuacauuac aggugguguu guucaguuga cuucgcagug     2100

gcuaacuaac aucuuuggca cuguuuauga aaaacucaaa cccguccuug auuggcuuga     2160

agagaaguuu aaggaaggug uagaguuucu uagagacggu ugggaaauug uuaaauuuau     2220

cucaaccugu gcuugugaaa uugucggugg acaaauuguc accugugcaa aggaaauuaa     2280

ggagaguguu cagacauucu uuaagcuugu aaauaaauuu uuggcuuugu gugcugacuc     2340

uaucauuauu gguggagcua aacuuaaagc cuugaauuua ggugaaacau uugucacgca     2400

cucaaaggga uuguacagaa aguguguuaa auccagagaa gaaacuggcc uacucaugcc     2460

ucuaaaagcc ccaaaagaaa uuaucuucuu agagggagaa acacuuccca cagaaguguu     2520

aacagaggaa guugucuuga aaacugguga uuuacaacca uuagaacaac cuacuaguga     2580

agcuguugaa gcuccauugg uugguacacc aguuuguauu aacgggcuua uguugcucga     2640

aaucaaagac acagaaaagu acugugcccu ugcaccuaau augaugguaa caaacaauac     2700

cuucacacuc aaaggcggug caccaacaaa gguuacuuuu ggugaugaca cugugauaga     2760

agugcaaggu uacaagagug ugaauaucac uuuugaacuu gaugaaagga uugauaaagu     2820

acuuaaugag aagugcucug ccuauacagu ugaacucggu acagaaguaa augaguucgc     2880

cuguguugug gcagaugcug ucauaaaaac uuugcaacca guaucugaau uacuuacacc     2940

acugggcauu gauuuagaug aguggaguau ggcuacauac uacuuauuug augagucugg     3000

ugaguuuaaa uuggcuucac auauguauug uucuuucuac ccuccagaug aggaugaaga     3060

agaaggugau ugugaagaag aagaguuuga gccaucaacu caauaugagu augguacuga     3120

agaugauuac caagguaaac cuuuggaauu uggugccacu ucugcugcuc uucaaccuga     3180

agaagagcaa gaagaagauu gguuagauga ugauagucaa caaacuguug gucaacaaga     3240

cggcagugag gacaaucaga caacuacuau ucaaacaauu guugagguuc aaccucaauu     3300

agagauggaa cuuacaccag uuguucagac uauugaagug aauaguuuua gugguuauuu     3360

aaaacuuacu gacaauguau acauuaaaaa ugcagacauu guggaagaag cuaaaaaggu     3420

aaaaccaaca gugguuguua augcagccaa uguuuaccuu aaacauggag gagguguugc     3480

aggagccuua aauaaggcua cuaacaaugc caugcaaguu gaaucugaug auuacauagc     3540

uacuaaugga ccacuuaaag ugggugguag uuguguuuua agcggacaca aucuugcuaa     3600

acacugucuu cauguugucg gcccaaaugu uaacaaaggu gaagacauuc aacuucuuaa     3660

gagugcuuau gaaaauuuua aucagcacga aguucuacuu gcaccauuau uaucagcugg     3720

uauuuuuggu gcugacccua uacauucuuu aagaguuugu guagauacug uucgcacaaa     3780

ugucuacuua gcugucuuug auaaaaaucu cuaugacaaa cuuguuucaa gcuuuuugga     3840

aaugaagagu gaaaagcaag uugaacaaaa gaucgcugag auuccuaaag aggaaguuaa     3900

gccauuuaua acugaaagua aaccuucagu ugaacagaga aaacaagaug auaagaaaau     3960

caaagcuugu guugaagaag uuacaacaac ucuggaagaa acuaaguucc ucacagaaaa     4020

cuuguuacuu uauauugaca uuaauggcaa ucuucaucca gauucugcca cucuuguuag     4080

ugacauugac aucacuuucu uaaagaaaga ugcuccauau auagugggug auguuguuca     4140

agaggguguu uuaacugcug ugguuauacc uacuaaaaag gcugguggca cuacugaaau     4200

gcuagcgaaa gcuuugagaa aagugccaac agacaauuau auaaccacuu acccggguca     4260

ggguuuaaau gguuacacug uagaggaggc aaagacagug cuuaaaaagu guaaaagugc     4320

cuuuuacauu cuaccaucua uuaucucuaa ugagaagcaa gaaauucuug gaacuguuuc     4380

uuggaauuug cgagaaaugc uugcacaugc agaagaaaca cgcaaauuaa ugccugucug     4440

uguggaaacu aaagccauag uuucaacuau acagcguaaa uauaagggua uuaaaauaca     4500

agagggugug guugauuaug gugcuagauu uuacuuuuac accaguaaaa caacuguagc     4560

gucacuuauc aacacacuua acgaucuaaa ugaaacucuu guuacaaugc cacuuggcua     4620

uguaacacau ggcuuaaauu uggaagaagc ugcucgguau augagaucuc ucaaagugcc     4680

agcuacaguu ucuguuucuu caccugaugc uguuacagcg uauaaugguu aucuuacuuc     4740

uucuucuaaa acaccugaag aacauuuuau ugaaaccauc ucacuugcug guuccuauaa     4800

agauuggucc uauucuggac aaucuacaca acuagguaua gaauuucuua agagagguga     4860

uaaaagugua uauuacacua guaauccuac cacauuccac cuagauggug aaguuaucac     4920

cuuugacaau cuuaagacac uucuuucuuu gagagaagug aggacuauua agguguuuac     4980

aacaguagac aacauuaacc uccacacgca aguuguggac augucaauga cauauggaca     5040

acaguuuggu ccaacuuauu uggauggagc ugauguuacu aaaauaaaac cucauaauuc     5100

acaugaaggu aaaacauuuu auguuuuacc uaaugaugac acucuacgug uugaggcuuu     5160

ugaguacuac cacacaacug auccuaguuu ucuggguagg uacaugucag cauuaaauca     5220

cacuaaaaag uggaaauacc cacaaguuaa ugguuuaacu ucuauuaaau gggcagauaa     5280

caacuguuau cuugccacug cauuguuaac acuccaacaa auagaguuga aguuuaaucc     5340

accugcucua caagaugcuu auuacagagc aagggcuggu gaagcugcua acuuuugugc     5400

acuuaucuua gccuacugua auaagacagu aggugaguua ggugauguua gagaaacaau     5460

gaguuacuug uuucaacaug ccaauuuaga uucuugcaaa agagucuuga acguggugug     5520

uaaaacuugu ggacaacagc agacaacccu uaagggugua gaagcuguua uguacauggg     5580

cacacuuucu uaugaacaau uuaagaaagg uguucagaua ccuuguacgu gugguaaaca     5640

agcuacaaaa uaucuaguac aacaggaguc accuuuuguu augaugucag caccaccugc     5700

ucaguaugaa cuuaagcaug guacauuuac uugugcuagu gaguacacug guaauuacca     5760

guguggucac uauaaacaua uaacuucuaa agaaacuuug uauugcauag acggugcuuu     5820

acuuacaaag uccucagaau acaaaggucc uauuacggau guuuucuaca aagaaaacag     5880

uuacacaaca accauaaaac caguuacuua uaaauuggau gguguuguuu guacagaaau     5940

ugacccuaag uuggacaauu auuauaagaa agacaauucu uauuucacag agcaaccaau     6000

ugaucuugua ccaaaccaac cauauccaaa cgcaagcuuc gauaauuuua aguuuguaug     6060

ugauaauauc aaauuugcug augauuuaaa ccaguuaacu gguuauaaga aaccugcuuc     6120

aagagagcuu aaaguuacau uuuucccuga cuuaaauggu gauguggugg cuauugauua     6180

uaaacacuac acacccucuu uuaagaaagg agcuaaauug uuacauaaac cuauuguuug     6240

gcauguuaac aaugcaacua auaaagccac guauaaacca aauaccuggu guauacguug     6300

ucuuuggagc acaaaaccag uugaaacauc aaauucguuu gauguacuga agucagagga     6360

cgcgcaggga auggauaauc uugccugcga agaucuaaaa ccagucucug aagaaguagu     6420

ggaaaauccu accauacaga aagacguucu ugaguguaau gugaaaacua ccgaaguugu     6480

aggagacauu auacuuaaac cagcaaauaa uaguuuaaaa auuacagaag agguuggcca     6540

cacagaucua auggcugcuu auguagacaa uucuagucuu acuauuaaga aaccuaauga     6600

auuaucuaga guauuagguu ugaaaacccu ugcuacucau gguuuagcug cuguuaauag     6660

ugucccuugg gauacuauag cuaauuaugc uaagccuuuu cuuaacaaag uuguuaguac     6720

aacuacuaac auaguuacac gguguuuaaa ccguguuugu acuaauuaua ugccuuauuu     6780

cuuuacuuua uugcuacaau uguguacuuu uacuagaagu acaaauucua gaauuaaagc     6840

aucuaugccg acuacuauag caaagaauac uguuaagagu gucgguaaau uuugucuaga     6900

ggcuucauuu aauuauuuga agucaccuaa uuuuucuaaa cugauaaaua uuauaauuug     6960

guuuuuacua uuaaguguuu gccuagguuc uuuaaucuac ucaaccgcug cuuuaggugu     7020

uuuaaugucu aauuuaggca ugccuucuua cuguacuggu uacagagaag gcuauuugaa     7080

cucuacuaau gucacuauug caaccuacug uacugguucu auaccuugua guguuugucu     7140

uagugguuua gauucuuuag acaccuaucc uucuuuagaa acuauacaaa uuaccauuuc     7200

aucuuuuaaa ugggauuuaa cugcuuuugg cuuaguugca gagugguuuu uggcauauau     7260

ucuuuucacu agguuuuucu auguacuugg auuggcugca aucaugcaau uguuuuucag     7320

cuauuuugca guacauuuua uuaguaauuc uuggcuuaug ugguuaauaa uuaaucuugu     7380

acaaauggcc ccgauuucag cuaugguuag aauguacauc uucuuugcau cauuuuauua     7440

uguauggaaa aguuaugugc auguuguaga cgguuguaau ucaucaacuu guaugaugug     7500

uuacaaacgu aauagagcaa caagagucga auguacaacu auuguuaaug guguuagaag     7560

guccuuuuau gucuaugcua auggagguaa aggcuuuugc aaacuacaca auuggaauug     7620

uguuaauugu gauacauucu gugcugguag uacauuuauu agugaugaag uugcgagaga     7680

cuugucacua caguuuaaaa gaccaauaaa uccuacugac cagucuucuu acaucguuga     7740

uaguguuaca gugaagaaug guuccaucca ucuuuacuuu gauaaagcug gucaaaagac     7800

uuaugaaaga cauucucucu cucauuuugu uaacuuagac aaccugagag cuaauaacac     7860

uaaagguuca uugccuauua auguuauagu uuuugauggu aaaucaaaau gugaagaauc     7920

aucugcaaaa ucagcgucug uuuacuacag ucagcuuaug ugucaaccua uacuguuacu     7980

agaucaggca uuagugucug auguugguga uagugcggaa guugcaguua aaauguuuga     8040

ugcuuacguu aauacguuuu caucaacuuu uaacguacca auggaaaaac ucaaaacacu     8100

aguugcaacu gcagaagcug aacuugcaaa gaaugugucc uuagacaaug ucuuaucuac     8160

uuuuauuuca gcagcucggc aaggguuugu ugauucagau guagaaacua aagauguugu     8220

ugaaugucuu aaauugucac aucaaucuga cauagaaguu acuggcgaua guuguaauaa     8280

cuauaugcuc accuauaaca aaguugaaaa caugacaccc cgugaccuug gugcuuguau     8340

ugacuguagu gcgcgucaua uuaaugcgca gguagcaaaa agucacaaca uugcuuugau     8400

auggaacguu aaagauuuca ugucauuguc ugaacaacua cgaaaacaaa uacguagugc     8460

ugcuaaaaag aauaacuuac cuuuuaaguu gacaugugca acuacuagac aaguuguuaa     8520

uguuguaaca acaaagauag cacuuaaggg ugguaaaauu guuaauaauu gguugaagca     8580

guuaauuaaa guuacacuug uguuccuuuu uguugcugcu auuuucuauu uaauaacacc     8640

uguucauguc augucuaaac auacugacuu uucaagugaa aucauaggau acaaggcuau     8700

ugaugguggu gucacucgug acauagcauc uacagauacu uguuuugcua acaaacaugc     8760

ugauuuugac acaugguuua gccagcgugg ugguaguuau acuaaugaca aagcuugccc     8820

auugauugcu gcagucauaa caagagaagu ggguuuuguc gugccugguu ugccuggcac     8880

gauauuacgc acaacuaaug gugacuuuuu gcauuucuua ccuagaguuu uuagugcagu     8940

ugguaacauc uguuacacac caucaaaacu uauagaguac acugacuuug caacaucagc     9000

uuguguuuug gcugcugaau guacaauuuu uaaagaugcu ucugguaagc caguaccaua     9060

uuguuaugau accaauguac uagaagguuc uguugcuuau gaaaguuuac gcccugacac     9120

acguuaugug cucauggaug gcucuauuau ucaauuuccu aacaccuacc uugaagguuc     9180

uguuagagug guaacaacuu uugauucuga guacuguagg cacggcacuu gugaaagauc     9240

agaagcuggu guuuguguau cuacuagugg uagaugggua cuuaacaaug auuauuacag     9300

aucuuuacca ggaguuuucu gugguguaga ugcuguaaau uuacuuacua auauguuuac     9360

accacuaauu caaccuauug gugcuuugga cauaucagca ucuauaguag cuggugguau     9420

uguagcuauc guaguaacau gccuugccua cuauuuuaug agguuuagaa gagcuuuugg     9480

ugaauacagu cauguaguug ccuuuaauac uuuacuauuc cuuaugucau ucacuguacu     9540

cuguuuaaca ccaguuuacu cauucuuacc ugguguuuau ucuguuauuu acuuguacuu     9600

gacauuuuau cuuacuaaug auguuucuuu uuuagcacau auucagugga ugguuauguu     9660

cacaccuuua guaccuuucu ggauaacaau ugcuuauauc auuuguauuu ccacaaagca     9720

uuucuauugg uucuuuagua auuaccuaaa gagacgugua gucuuuaaug guguuuccuu     9780

uaguacuuuu gaagaagcug cgcugugcac cuuuuuguua aauaaagaaa uguaucuaaa     9840

guugcguagu gaugugcuau uaccucuuac gcaauauaau agauacuuag cucuuuauaa     9900

uaaguacaag uauuuuagug gagcaaugga uacaacuagc uacagagaag cugcuuguug     9960

ucaucucgca aaggcucuca augacuucag uaacucaggu ucugauguuc uuuaccaacc    10020

accacaaacc ucuaucaccu cagcuguuuu gcagaguggu uuuagaaaaa uggcauuccc    10080

aucugguaaa guugaggguu guaugguaca aguaacuugu gguacaacua cacuuaacgg    10140

ucuuuggcuu gaugacguag uuuacugucc aagacaugug aucugcaccu cugaagacau    10200

gcuuaacccu aauuaugaag auuuacucau ucguaagucu aaucauaauu ucuugguaca    10260

ggcugguaau guucaacuca ggguuauugg acauucuaug caaaauugug uacuuaagcu    10320

uaagguugau acagccaauc cuaagacacc uaaguauaag uuuguucgca uucaaccagg    10380

acagacuuuu ucaguguuag cuuguuacaa ugguucacca ucugguguuu accaaugugc    10440

uaugaggccc aauuucacua uuaaggguuc auuccuuaau gguucaugug guaguguugg    10500

uuuuaacaua gauuaugacu gugucucuuu uuguuacaug caccauaugg aauuaccaac    10560

uggaguucau gcuggcacag acuuagaagg uaacuuuuau ggaccuuuug uugacaggca    10620

aacagcacaa gcagcuggua cggacacaac uauuacaguu aauguuuuag cuugguugua    10680

cgcugcuguu auaaauggag acaggugguu ucucaaucga uuuaccacaa cucuuaauga    10740

cuuuaaccuu guggcuauga aguacaauua ugaaccucua acacaagacc auguugacau    10800

acuaggaccu cuuucugcuc aaacuggaau ugccguuuua gauaugugug cuucauuaaa    10860

agaauuacug caaaauggua ugaauggacg uaccauauug gguagugcuu uauuagaaga    10920

ugaauuuaca ccuuuugaug uuguuagaca augcucaggu guuacuuucc aaagugcagu    10980

gaaaagaaca aucaagggua cacaccacug guuguuacuc acaauuuuga cuucacuuuu    11040

aguuuuaguc cagaguacuc aauggucuuu guucuuuuuu uuguaugaaa augccuuuuu    11100

accuuuugcu auggguauua uugcuauguc ugcuuuugca augauguuug ucaaacauaa    11160

gcaugcauuu cucuguuugu uuuuguuacc uucucuugcc acuguagcuu auuuuaauau    11220

ggucuauaug ccugcuaguu gggugaugcg uauuaugaca ugguuggaua ugguugauac    11280

uaguuugucu gguuuuaagc uaaaagacug uguuauguau gcaucagcug uaguguuacu    11340

aauccuuaug acagcaagaa cuguguauga ugauggugcu aggagagugu ggacacuuau    11400

gaaugucuug acacucguuu auaaaguuua uuaugguaau gcuuuagauc aagccauuuc    11460

caugugggcu cuuauaaucu cuguuacuuc uaacuacuca gguguaguua caacugucau    11520

guuuuuggcc agagguauug uuuuuaugug uguugaguau ugcccuauuu ucuucauaac    11580

ugguaauaca cuucagugua uaaugcuagu uuauuguuuc uuaggcuauu uuuguacuug    11640

uuacuuuggc cucuuuuguu uacucaaccg cuacuuuaga cugacucuug guguuuauga    11700

uuacuuaguu ucuacacagg aguuuagaua uaugaauuca cagggacuac ucccacccaa    11760

gaauagcaua gaugccuuca aacucaacau uaaauuguug gguguuggug gcaaaccuug    11820

uaucaaagua gccacuguac ag ucu aaa aug uca gau gua aag ugc aca uca     11872
                         Ser Lys Met Ser Asp Val Lys Cys Thr Ser          
                         1               5                   10           

gua guc uua cuc uca guu uug caa caa cuc aga gua gaa uca uca ucu      11920
Val Val Leu Leu Ser Val Leu Gln Gln Leu Arg Val Glu Ser Ser Ser           
                15                  20                  25                

aaa uug ugg gcu caa ugu guc cag uua cac aau gac auu cuc uua gcu      11968
Lys Leu Trp Ala Gln Cys Val Gln Leu His Asn Asp Ile Leu Leu Ala           
            30                  35                  40                    

aaa gau acu acu gaa gcc uuu gaa aaa aug guu uca cua cuu ucu guu      12016
Lys Asp Thr Thr Glu Ala Phe Glu Lys Met Val Ser Leu Leu Ser Val           
        45                  50                  55                        

uug cuu ucc aug cag ggu gcu gua gac aua aac aag cuu ugu gaa gaa      12064
Leu Leu Ser Met Gln Gly Ala Val Asp Ile Asn Lys Leu Cys Glu Glu           
    60                  65                  70                            

aug cug gac aac agg gca acc uua caa gcu aua gcc uca gag uuu agu      12112
Met Leu Asp Asn Arg Ala Thr Leu Gln Ala Ile Ala Ser Glu Phe Ser           
75                  80                  85                  90            

ucc cuu cca uca uau gca gcu uuu gcu acu gcu caa gaa gcu uau gag      12160
Ser Leu Pro Ser Tyr Ala Ala Phe Ala Thr Ala Gln Glu Ala Tyr Glu           
                95                  100                 105               

cag gcu guu gcu aau ggu gau ucu gaa guu guu cuu aaa aag uug aag      12208
Gln Ala Val Ala Asn Gly Asp Ser Glu Val Val Leu Lys Lys Leu Lys           
            110                 115                 120                   

aag ucu uug aau gug gcu aaa ucu gaa uuu gac cgu gau gca gcc aug      12256
Lys Ser Leu Asn Val Ala Lys Ser Glu Phe Asp Arg Asp Ala Ala Met           
        125                 130                 135                       

caa cgu aag uug gaa aag aug gcu gau caa gcu aug acc caa aug uau      12304
Gln Arg Lys Leu Glu Lys Met Ala Asp Gln Ala Met Thr Gln Met Tyr           
    140                 145                 150                           

aaa cag gcu aga ucu gag gac aag agg gca aaa guu acu agu gcu aug      12352
Lys Gln Ala Arg Ser Glu Asp Lys Arg Ala Lys Val Thr Ser Ala Met           
155                 160                 165                 170           

cag aca aug cuu uuc acu aug cuu aga aag uug gau aau gau gca cuc      12400
Gln Thr Met Leu Phe Thr Met Leu Arg Lys Leu Asp Asn Asp Ala Leu           
                175                 180                 185               

aac aac auu auc aac aau gca aga gau ggu ugu guu ccc uug aac aua      12448
Asn Asn Ile Ile Asn Asn Ala Arg Asp Gly Cys Val Pro Leu Asn Ile           
            190                 195                 200                   

aua ccu cuu aca aca gca gcc aaa cua aug guu guc aua cca gac uau      12496
Ile Pro Leu Thr Thr Ala Ala Lys Leu Met Val Val Ile Pro Asp Tyr           
        205                 210                 215                       

aac aca uau aaa aau acg ugu gau ggu aca aca uuu acu uau gca uca      12544
Asn Thr Tyr Lys Asn Thr Cys Asp Gly Thr Thr Phe Thr Tyr Ala Ser           
    220                 225                 230                           

gca uug ugg gaa auc caa cag guu gua gau gca gau agu aaa auu guu      12592
Ala Leu Trp Glu Ile Gln Gln Val Val Asp Ala Asp Ser Lys Ile Val           
235                 240                 245                 250           

caa cuu agu gaa auu agu aug gac aau uca ccu aau uua gca ugg ccu      12640
Gln Leu Ser Glu Ile Ser Met Asp Asn Ser Pro Asn Leu Ala Trp Pro           
                255                 260                 265               

cuu auu gua aca gcu uua agg gcc aau ucu gcu guc aaa uua cag          12685
Leu Ile Val Thr Ala Leu Arg Ala Asn Ser Ala Val Lys Leu Gln               
            270                 275                 280                   

aauaaugagc uuaguccugu ugcacuacga cagaugucuu gugcugccgg uacuacacaa    12745

acugcuugca cugaugacaa ugcguuagcu uacuacaaca caacaaaggg agguagguuu    12805

guacuugcac uguuauccga uuuacaggau uugaaauggg cuagauuccc uaagagugau    12865

ggaacuggua cuaucuauac agaacuggaa ccaccuugua gguuuguuac agacacaccu    12925

aaagguccua aagugaagua uuuauacuuu auuaaaggau uaaacaaccu aaauagaggu    12985

augguacuug guaguuuagc ugccacagua cgucuacaag cugguaaugc aacagaagug    13045

ccugccaauu caacuguauu aucuuucugu gcuuuugcug uagaugcugc uaaagcuuac    13105

aaagauuauc uagcuagugg gggacaacca aucacuaauu guguuaagau guuguguaca    13165

cacacuggua cuggucaggc aauaacaguu acaccggaag ccaauaugga ucaagaaucc    13225

uuugguggug caucguguug ucuguacugc cguugccaca uagaucaucc aaauccuaaa    13285

ggauuuugug acuuaaaagg uaaguaugua caaauaccua caacuugugc uaaugacccu    13345

guggguuuua cacuuaaaaa cacagucugu accgucugcg guauguggaa agguuauggc    13405

uguaguugug aucaacuccg cgaacccaug cuucag uca gcu gau gca caa ucg      13459
                                        Ser Ala Asp Ala Gln Ser           
                                                    285                   

uuu uua aac ggg uuu gcg gug uaa gug cag ccc guc uua cac cgu gcg      13507
Phe Leu Asn Gly Phe Ala Val     Val Gln Pro Val Leu His Arg Ala           
        290                     295                 300                   

gca cag gca cua gua cug aug ucg uau aca ggg cuu uug aca ucu aca      13555
Ala Gln Ala Leu Val Leu Met Ser Tyr Thr Gly Leu Leu Thr Ser Thr           
        305                 310                 315                       

aug aua aag uag cug guu uug cua aau ucc uaa aaa cua auu guu guc      13603
Met Ile Lys     Leu Val Leu Leu Asn Ser     Lys Leu Ile Val Val           
    320                     325                     330                   

gcu ucc aag aaa agg acg aag aug aca auu uaa uug auu cuu acu uug      13651
Ala Ser Lys Lys Arg Thr Lys Met Thr Ile     Leu Ile Leu Thr Leu           
        335                 340                     345                   

uag uua aga gac aca cuu ucu cua acu acc aac aug aag aaa caa uuu      13699
    Leu Arg Asp Thr Leu Ser Leu Thr Thr Asn Met Lys Lys Gln Phe           
            350                 355                 360                   

aua auu uac uua agg auu guc cag cug uug cua aac aug acu ucu uua      13747
Ile Ile Tyr Leu Arg Ile Val Gln Leu Leu Leu Asn Met Thr Ser Leu           
        365                 370                 375                       

agu uua gaa uag acg gug aca ugg uac cac aua uau cac guc aac guc      13795
Ser Leu Glu     Thr Val Thr Trp Tyr His Ile Tyr His Val Asn Val           
    380                     385                 390                       

uua cua aau aca caa ugg cag acc ucg ucu aug cuu uaa ggc auu uug      13843
Leu Leu Asn Thr Gln Trp Gln Thr Ser Ser Met Leu     Gly Ile Leu           
    395                 400                 405                           

aug aag gua auu gug aca cau uaa aag aaa uac uug uca cau aca auu      13891
Met Lys Val Ile Val Thr His     Lys Lys Tyr Leu Ser His Thr Ile           
    410                 415                     420                       

guu gug aug aug auu auu uca aua aaa agg acu ggu aug auu uug uag      13939
Val Val Met Met Ile Ile Ser Ile Lys Arg Thr Gly Met Ile Leu               
    425                 430                 435                           

aaa acc cag aua uau uac gcg uau acg cca acu uag gug aac gug uac      13987
Lys Thr Gln Ile Tyr Tyr Ala Tyr Thr Pro Thr     Val Asn Val Tyr           
    440                 445                     450                       

gcc aag cuu ugu uaa aaa cag uac aau ucu gug aug cca ugc gaa aug      14035
Ala Lys Leu Cys     Lys Gln Tyr Asn Ser Val Met Pro Cys Glu Met           
    455                     460                 465                       

cug gua uug uug gug uac uga cau uag aua auc aag auc uca aug gua      14083
Leu Val Leu Leu Val Tyr     His     Ile Ile Lys Ile Ser Met Val           
    470                     475                     480                   

acu ggu aug auu ucg gug auu uca uac aaa cca cgc cag gua gug gag      14131
Thr Gly Met Ile Ser Val Ile Ser Tyr Lys Pro Arg Gln Val Val Glu           
        485                 490                 495                       

uuc cug uug uag auu cuu auu auu cau ugu uaa ugc cua uau uaa ccu      14179
Phe Leu Leu     Ile Leu Ile Ile His Cys     Cys Leu Tyr     Pro           
    500                     505                     510                   

uga cca ggg cuu uaa cug cag agu cac aug uug aca cug acu uaa caa      14227
    Pro Gly Leu     Leu Gln Ser His Met Leu Thr Leu Thr     Gln           
                    515                 520                               

agc cuu aca uua agu ggg auu ugu uaa aau aug acu uca cgg aag aga      14275
Ser Leu Thr Leu Ser Gly Ile Cys     Asn Met Thr Ser Arg Lys Arg           
525                 530                     535                           

ggu uaa aac ucu uug acc guu auu uua aau auu ggg auc aga cau acc      14323
Gly     Asn Ser Leu Thr Val Ile Leu Asn Ile Gly Ile Arg His Thr           
540                     545                 550                           

acc caa auu gug uua acu guu ugg aug aca gau gca uuc ugc auu gug      14371
Thr Gln Ile Val Leu Thr Val Trp Met Thr Asp Ala Phe Cys Ile Val           
555                 560                 565                 570           

caa acu uua aug uuu uau ucu cua cag ugu ucc cac cua caa guu uug      14419
Gln Thr Leu Met Phe Tyr Ser Leu Gln Cys Ser His Leu Gln Val Leu           
                575                 580                 585               

gac cac uag uga gaa aaa uau uug uug aug gug uuc cau uug uag uuu      14467
Asp His         Glu Lys Tyr Leu Leu Met Val Phe His Leu     Phe           
                    590                 595                               

caa cug gau acc acu uca gag agc uag gug uug uac aua auc agg aug      14515
Gln Leu Asp Thr Thr Ser Glu Ser     Val Leu Tyr Ile Ile Arg Met           
600                 605                     610                           

uaa acu uac aua gcu cua gac uua guu uua agg aau uac uug ugu aug      14563
    Thr Tyr Ile Ala Leu Asp Leu Val Leu Arg Asn Tyr Leu Cys Met           
    615                 620                 625                           

cug cug acc cug cua ugc acg cug cuu cug gua auc uau uac uag aua      14611
Leu Leu Thr Leu Leu Cys Thr Leu Leu Leu Val Ile Tyr Tyr     Ile           
630                 635                 640                               

aac gca cua cgu gcu uuu cag uag cug cac uua cua aca aug uug cuu      14659
Asn Ala Leu Arg Ala Phe Gln     Leu His Leu Leu Thr Met Leu Leu           
645                 650                     655                           

uuc aaa cug uca aac ccg gua auu uua aca aag acu ucu aug acu uug      14707
Phe Lys Leu Ser Asn Pro Val Ile Leu Thr Lys Thr Ser Met Thr Leu           
660                 665                 670                 675           

cug ugu cua agg guu ucu uua agg aag gaa guu cug uug aau uaa aac      14755
Leu Cys Leu Arg Val Ser Leu Arg Lys Glu Val Leu Leu Asn     Asn           
                680                 685                     690           

acu ucu ucu uug cuc agg aug gua aug cug cua uca gcg auu aug acu      14803
Thr Ser Ser Leu Leu Arg Met Val Met Leu Leu Ser Ala Ile Met Thr           
                695                 700                 705               

acu auc guu aua auc uac caa caa ugu gug aua uca gac aac uac uau      14851
Thr Ile Val Ile Ile Tyr Gln Gln Cys Val Ile Ser Asp Asn Tyr Tyr           
            710                 715                 720                   

uug uag uug aag uug uug aua agu acu uug auu guu acg aug gug gcu      14899
Leu     Leu Lys Leu Leu Ile Ser Thr Leu Ile Val Thr Met Val Ala           
            725                 730                 735                   

gua uua aug cua acc aag uca ucg uca aca acc uag aca aau cag cug      14947
Val Leu Met Leu Thr Lys Ser Ser Ser Thr Thr     Thr Asn Gln Leu           
        740                 745                     750                   

guu uuc cau uua aua aau ggg gua agg cua gac uuu auu aug auu caa      14995
Val Phe His Leu Ile Asn Gly Val Arg Leu Asp Phe Ile Met Ile Gln           
        755                 760                 765                       

uga guu aug agg auc aag aug cac uuu ucg cau aua caa aac gua aug      15043
    Val Met Arg Ile Lys Met His Phe Ser His Ile Gln Asn Val Met           
        770                 775                 780                       

uca ucc cua cua uaa cuc aaa uga auc uua agu aug cca uua gug caa      15091
Ser Ser Leu Leu     Leu Lys     Ile Leu Ser Met Pro Leu Val Gln           
    785                         790                 795                   

aga aua gag cuc gca ccg uag cug gug ucu cua ucu gua gua cua uga      15139
Arg Ile Glu Leu Ala Pro     Leu Val Ser Leu Ser Val Val Leu               
        800                     805                 810                   

cca aua gac agu uuc auc aaa aau uau uga aau caa uag ccg cca cua      15187
Pro Ile Asp Ser Phe Ile Lys Asn Tyr     Asn Gln     Pro Pro Leu           
            815                 820                         825           

gag gag cua cug uag uaa uug gaa caa gca aau ucu aug gug guu ggc      15235
Glu Glu Leu Leu         Leu Glu Gln Ala Asn Ser Met Val Val Gly           
                        830                 835                           

aca aca ugu uaa aaa cug uuu aua gug aug uag aaa acc cuc acc uua      15283
Thr Thr Cys     Lys Leu Phe Ile Val Met     Lys Thr Leu Thr Leu           
840                     845                     850                       

ugg guu ggg auu auc cua aau gug aua gag cca ugc cua aca ugc uua      15331
Trp Val Gly Ile Ile Leu Asn Val Ile Glu Pro Cys Leu Thr Cys Leu           
    855                 860                 865                           

gaa uua ugg ccu cac uug uuc uug cuc gca aac aua caa cgu guu gua      15379
Glu Leu Trp Pro His Leu Phe Leu Leu Ala Asn Ile Gln Arg Val Val           
870                 875                 880                 885           

gcu ugu cac acc guu ucu aua gau uag cua aug agu gug cuc aag uau      15427
Ala Cys His Thr Val Ser Ile Asp     Leu Met Ser Val Leu Lys Tyr           
                890                     895                 900           

uga gug aaa ugg uca ugu gug gcg guu cac uau aug uua aac cag gug      15475
    Val Lys Trp Ser Cys Val Ala Val His Tyr Met Leu Asn Gln Val           
                    905                 910                 915           

gaa ccu cau cag gag aug cca caa cug cuu aug cua aua gug uuu uua      15523
Glu Pro His Gln Glu Met Pro Gln Leu Leu Met Leu Ile Val Phe Leu           
                920                 925                 930               

aca uuu guc aag cug uca cgg cca aug uua aug cac uuu uau cua cug      15571
Thr Phe Val Lys Leu Ser Arg Pro Met Leu Met His Phe Tyr Leu Leu           
            935                 940                 945                   

aug gua aca aaa uug ccg aua agu aug ucc gca auu uac aac aca gac      15619
Met Val Thr Lys Leu Pro Ile Ser Met Ser Ala Ile Tyr Asn Thr Asp           
        950                 955                 960                       

uuu aug agu guc ucu aua gaa aua gag aug uug aca cag acu uug uga      15667
Phe Met Ser Val Ser Ile Glu Ile Glu Met Leu Thr Gln Thr Leu               
    965                 970                 975                           

aug agu uuu acg cau auu ugc gua aac auu ucu caa uga uga uac ucu      15715
Met Ser Phe Thr His Ile Cys Val Asn Ile Ser Gln         Tyr Ser           
    980                 985                 990                           

cug acg aug cug uug ugu guu uca  aua gca cuu aug cau  cuc aag guc    15763
Leu Thr Met Leu Leu Cys Val Ser  Ile Ala Leu Met His  Leu Lys Val         
        995                 1000                 1005                     

uag ugg cua  gca uaa aga acu uua agu  cag uuc uuu auu auc  aaa       15808
    Trp Leu  Ala     Arg Thr Leu Ser  Gln Phe Phe Ile Ile  Lys            
        1010                     1015                 1020                

aca aug uuu uua  ugu cug aag caa aau  guu gga cug aga cug  acc       15853
Thr Met Phe Leu  Cys Leu Lys Gln Asn  Val Gly Leu Arg Leu  Thr            
            1025                 1030                 1035                

uua cua aag gac  cuc aug aau uuu gcu  cuc aac aua caa ugc  uag       15898
Leu Leu Lys Asp  Leu Met Asn Phe Ala  Leu Asn Ile Gln Cys                 
            1040                 1045                 1050                

uua aac agg gug aug  auu aug ugu acc uuc  cuu acc cag auc cau        15943
Leu Asn Arg Val Met  Ile Met Cys Thr Phe  Leu Thr Gln Ile His             
                1055                 1060                 1065            

caa gaa ucc uag ggg ccg  gcu guu uug uag aug aua  ucg uaa aaa cag    15991
Gln Glu Ser     Gly Pro  Ala Val Leu     Met Ile  Ser     Lys Gln         
                    1070                     1075                         

aug gua  cac uua uga uug aac ggu  ucg ugu cuu uag cua uag aug        16036
Met Val  His Leu     Leu Asn Gly  Ser Cys Leu     Leu     Met             
    1080                     1085                         1090            

cuu acc cac uua cua  aac auc cua auc agg  agu aug cug aug ucu        16081
Leu Thr His Leu Leu  Asn Ile Leu Ile Arg  Ser Met Leu Met Ser             
                1095                 1100                 1105            

uuc auu ugu acu uac  aau aca uaa gaa agc uac  aug aug agu uaa cag    16129
Phe Ile Cys Thr Tyr  Asn Thr     Glu Ser Tyr  Met Met Ser     Gln         
                1110                     1115                             

gac  aca ugu uag aca ugu auu  cug uua ugc uua cua  aug aua aca       16174
Asp  Thr Cys     Thr Cys Ile  Leu Leu Cys Leu Leu  Met Ile Thr            
1120                     1125                 1130                        

cuu caa  ggu auu ggg aac cug  agu uuu aug agg cua  ugu aca cac       16219
Leu Gln  Gly Ile Gly Asn Leu  Ser Phe Met Arg Leu  Cys Thr His            
    1135                 1140                 1145                        

cgc aua  cag ucu uac agg cuguuggggc uuguguucuu ugcaauucac            16267
Arg Ile  Gln Ser Tyr Arg                                                  
    1150                                                                  

agacuucauu aagauguggu gcuugcauac guagaccauu cuuauguugu aaaugcuguu    16327

acgaccaugu cauaucaaca ucacauaaau uagucuuguc uguuaauccg uauguuugca    16387

augcuccagg uugugauguc acagauguga cucaacuuua cuuaggaggu augagcuauu    16447

auuguaaauc acauaaacca cccauuaguu uuccauugug ugcuaaugga caaguuuuug    16507

guuuauauaa aaauacaugu guugguagcg auaauguuac ugacuuuaau gcaauugcaa    16567

caugugacug gacaaaugcu ggugauuaca uuuuagcuaa caccuguacu gaaagacuca    16627

agcuuuuugc agcagaaacg cucaaagcua cugaggagac auuuaaacug ucuuauggua    16687

uugcuacugu acgugaagug cugucugaca gagaauuaca ucuuucaugg gaaguuggua    16747

aaccuagacc accacuuaac cgaaauuaug ucuuuacugg uuaucgugua acuaaaaaca    16807

guaaaguaca aauaggagag uacaccuuug aaaaagguga cuauggugau gcuguuguuu    16867

accgagguac aacaacuuac aaauuaaaug uuggugauua uuuugugcug acaucacaua    16927

caguaaugcc auuaagugca ccuacacuag ugccacaaga gcacuauguu agaauuacug    16987

gcuuauaccc aacacucaau aucucagaug aguuuucuag caauguugca aauuaucaaa    17047

agguugguau gcaaaaguau ucuacacucc agggaccacc ugguacuggu aagagucauu    17107

uugcuauugg ccuagcucuc uacuacccuu cugcucgcau aguguauaca gcuugcucuc    17167

augccgcugu ugaugcacua ugugagaagg cauuaaaaua uuugccuaua gauaaaugua    17227

guagaauuau accugcacgu gcucguguag aguguuuuga uaaauucaaa gugaauucaa    17287

cauuagaaca guaugucuuu uguacuguaa augcauugcc ugagacgaca gcagauauag    17347

uugucuuuga ugaaauuuca auggccacaa auuaugauuu gaguguuguc aaugccagau    17407

uacgugcuaa gcacuaugug uacauuggcg acccugcuca auuaccugca ccacgcacau    17467

ugcuaacuaa gggcacacua gaaccagaau auuucaauuc aguguguaga cuuaugaaaa    17527

cuauaggucc agacauguuc cucggaacuu gucggcguug uccugcugaa auuguugaca    17587

cugugagugc uuugguuuau gauaauaagc uuaaagcaca uaaagacaaa ucagcucaau    17647

gcuuuaaaau guuuuauaag gguguuauca cgcaugaugu uucaucugca auuaacaggc    17707

cacaaauagg cgugguaaga gaauuccuua cacguaaccc ugcuuggaga aaagcugucu    17767

uuauuucacc uuauaauuca cagaaugcug uagccucaaa gauuuuggga cuaccaacuc    17827

aaacuguuga uucaucacag ggcucagaau augacuaugu cauauucacu caaaccacug    17887

aaacagcuca cucuuguaau guaaacagau uuaauguugc uauuaccaga gcaaaaguag    17947

gcauacuuug cauaaugucu gauagagacc uuuaugacaa guugcaauuu acaagucuug    18007

aaauuccacg uaggaaugug gcaacuuuac aa gcu  gaa aau gua aca gga  cuc    18060
                                    Ala  Glu Asn Val Thr Gly  Leu         
                                    1155                 1160             

uuu aaa gau ugu  agu aag gua auc acu  ggg uua cau ccu aca  cag       18105
Phe Lys Asp Cys  Ser Lys Val Ile Thr  Gly Leu His Pro Thr  Gln            
            1165                 1170                 1175                

gca ccu aca cac  cuc agu guu gac acu  aaa uuc aaa acu gaa  ggu       18150
Ala Pro Thr His  Leu Ser Val Asp Thr  Lys Phe Lys Thr Glu  Gly            
            1180                 1185                 1190                

uua ugu guu gac  aua ccu ggc aua ccu  aag gac aug acc uau  aga       18195
Leu Cys Val Asp  Ile Pro Gly Ile Pro  Lys Asp Met Thr Tyr  Arg            
            1195                 1200                 1205                

aga cuc auc ucu  aug aug ggu uuu aaa  aug aau uau caa guu  aau       18240
Arg Leu Ile Ser  Met Met Gly Phe Lys  Met Asn Tyr Gln Val  Asn            
            1210                 1215                 1220                

ggu uac ccu aac  aug uuu auc acc cgc  gaa gaa gcu aua aga  cau       18285
Gly Tyr Pro Asn  Met Phe Ile Thr Arg  Glu Glu Ala Ile Arg  His            
            1225                 1230                 1235                

gua cgu gca ugg  auu ggc uuc gau guc  gag ggg ugu cau gcu  acu       18330
Val Arg Ala Trp  Ile Gly Phe Asp Val  Glu Gly Cys His Ala  Thr            
            1240                 1245                 1250                

aga gaa gcu guu  ggu acc aau uua ccu  uua cag cua ggu uuu  ucu       18375
Arg Glu Ala Val  Gly Thr Asn Leu Pro  Leu Gln Leu Gly Phe  Ser            
            1255                 1260                 1265                

aca ggu guu aac  cua guu gcu gua ccu  aca ggu uau guu gau  aca       18420
Thr Gly Val Asn  Leu Val Ala Val Pro  Thr Gly Tyr Val Asp  Thr            
            1270                 1275                 1280                

ccu aau aau aca  gau uuu ucc aga guu  agu gcu aaa cca ccg  ccu       18465
Pro Asn Asn Thr  Asp Phe Ser Arg Val  Ser Ala Lys Pro Pro  Pro            
            1285                 1290                 1295                

gga gau caa uuu  aaa cac cuc aua cca  cuu aug uac aaa gga  cuu       18510
Gly Asp Gln Phe  Lys His Leu Ile Pro  Leu Met Tyr Lys Gly  Leu            
            1300                 1305                 1310                

ccu ugg aau gua  gug cgu aua aag auu  gua caa aug uua agu  gac       18555
Pro Trp Asn Val  Val Arg Ile Lys Ile  Val Gln Met Leu Ser  Asp            
            1315                 1320                 1325                

aca cuu aaa aau  cuc ucu gac aga guc  gua uuu guc uua ugg  gca       18600
Thr Leu Lys Asn  Leu Ser Asp Arg Val  Val Phe Val Leu Trp  Ala            
            1330                 1335                 1340                

cau ggc uuu gag  uug aca ucu aug aag  uau uuu gug aaa aua  gga       18645
His Gly Phe Glu  Leu Thr Ser Met Lys  Tyr Phe Val Lys Ile  Gly            
            1345                 1350                 1355                

ccu gag cgc acc  ugu ugu cua ugu gau  aga cgu gcc aca ugc  uuu       18690
Pro Glu Arg Thr  Cys Cys Leu Cys Asp  Arg Arg Ala Thr Cys  Phe            
            1360                 1365                 1370                

ucc acu gcu uca  gac acu uau gcc ugu  ugg cau cau ucu auu  gga       18735
Ser Thr Ala Ser  Asp Thr Tyr Ala Cys  Trp His His Ser Ile  Gly            
            1375                 1380                 1385                

uuu gau uac guc  uau aau ccg uuu aug  auu gau guu caa caa  ugg       18780
Phe Asp Tyr Val  Tyr Asn Pro Phe Met  Ile Asp Val Gln Gln  Trp            
            1390                 1395                 1400                

ggu uuu aca ggu  aac cua caa agc aac  cau gau cug uau ugu  caa       18825
Gly Phe Thr Gly  Asn Leu Gln Ser Asn  His Asp Leu Tyr Cys  Gln            
            1405                 1410                 1415                

guc cau ggu aau  gca cau gua gcu agu  ugu gau gca auc aug  acu       18870
Val His Gly Asn  Ala His Val Ala Ser  Cys Asp Ala Ile Met  Thr            
            1420                 1425                 1430                

agg ugu cua gcu  guc cac gag ugc uuu  guu aag cgu guu gac  ugg       18915
Arg Cys Leu Ala  Val His Glu Cys Phe  Val Lys Arg Val Asp  Trp            
            1435                 1440                 1445                

acu auu gaa uau  ccu aua auu ggu gau  gaa cug aag auu aau  gcg       18960
Thr Ile Glu Tyr  Pro Ile Ile Gly Asp  Glu Leu Lys Ile Asn  Ala            
            1450                 1455                 1460                

gcu ugu aga aag  guu caa cac aug guu  guu aaa gcu gca uua  uua       19005
Ala Cys Arg Lys  Val Gln His Met Val  Val Lys Ala Ala Leu  Leu            
            1465                 1470                 1475                

gca gac aaa uuc  cca guu cuu cac gac  auu ggu aac ccu aaa  gcu       19050
Ala Asp Lys Phe  Pro Val Leu His Asp  Ile Gly Asn Pro Lys  Ala            
            1480                 1485                 1490                

auu aag ugu gua  ccu caa gcu gau gua  gaa ugg aag uuc uau  gau       19095
Ile Lys Cys Val  Pro Gln Ala Asp Val  Glu Trp Lys Phe Tyr  Asp            
            1495                 1500                 1505                

gca cag ccu ugu  agu gac aaa gcu uau  aaa aua gaa gaa uua  uuc       19140
Ala Gln Pro Cys  Ser Asp Lys Ala Tyr  Lys Ile Glu Glu Leu  Phe            
            1510                 1515                 1520                

uau ucu uau gcc  aca cau ucu gac aaa  uuc aca gau ggu gua  ugc       19185
Tyr Ser Tyr Ala  Thr His Ser Asp Lys  Phe Thr Asp Gly Val  Cys            
            1525                 1530                 1535                

cua uuu ugg aau  ugc aau guc gau aga  uau ccu gcu aau ucc  auu       19230
Leu Phe Trp Asn  Cys Asn Val Asp Arg  Tyr Pro Ala Asn Ser  Ile            
            1540                 1545                 1550                

guu ugu aga uuu  gac acu aga gug cua  ucu aac cuu aac uug  ccu       19275
Val Cys Arg Phe  Asp Thr Arg Val Leu  Ser Asn Leu Asn Leu  Pro            
            1555                 1560                 1565                

ggu ugu gau ggu  ggc agu uug uau gua  aau aaa cau gca uuc  cac       19320
Gly Cys Asp Gly  Gly Ser Leu Tyr Val  Asn Lys His Ala Phe  His            
            1570                 1575                 1580                

aca cca gcu uuu  gau aaa agu gcu uuu  guu aau uua aaa caa  uua       19365
Thr Pro Ala Phe  Asp Lys Ser Ala Phe  Val Asn Leu Lys Gln  Leu            
            1585                 1590                 1595                

cca uuu uuc uau  uac ucu gac agu cca  ugu gag ucu cau gga  aaa       19410
Pro Phe Phe Tyr  Tyr Ser Asp Ser Pro  Cys Glu Ser His Gly  Lys            
            1600                 1605                 1610                

caa gua gug uca  gau aua gau uau gua  cca cua aag ucu gcu  acg       19455
Gln Val Val Ser  Asp Ile Asp Tyr Val  Pro Leu Lys Ser Ala  Thr            
            1615                 1620                 1625                

ugu aua aca cgu  ugc aau uua ggu ggu  gcu guc ugu aga cau  cau       19500
Cys Ile Thr Arg  Cys Asn Leu Gly Gly  Ala Val Cys Arg His  His            
            1630                 1635                 1640                

gcu aau gag uac  aga uug uau cuc gau  gcu uau aac aug aug  auc       19545
Ala Asn Glu Tyr  Arg Leu Tyr Leu Asp  Ala Tyr Asn Met Met  Ile            
            1645                 1650                 1655                

uca gcu ggc uuu  agc uug ugg guu uac  aaa caa uuu gau acu  uau       19590
Ser Ala Gly Phe  Ser Leu Trp Val Tyr  Lys Gln Phe Asp Thr  Tyr            
            1660                 1665                 1670                

aac cuc ugg aac  acu uuu aca aga cuu  cag aguuuagaaa auguggcuuu      19640
Asn Leu Trp Asn  Thr Phe Thr Arg Leu  Gln                                 
            1675                 1680                                     

uaauguugua aauaagggac acuuugaugg acaacagggu gaaguaccag uuucuaucau    19700

uaauaacacu guuuacacaa aaguugaugg uguugaugua gaauuguuug aaaauaaaac    19760

aacauuaccu guuaauguag cauuugagcu uugggcuaag cgcaacauua aaccaguacc    19820

agaggugaaa auacucaaua auuugggugu ggacauugcu gcuaauacug ugaucuggga    19880

cuacaaaaga gaugcuccag cacauauauc uacuauuggu guuuguucua ugacugacau    19940

agccaagaaa ccaacugaaa cgauuugugc accacucacu gucuuuuuug augguagagu    20000

ugauggucaa guagacuuau uuagaaaugc ccguaauggu guucuuauua cagaagguag    20060

uguuaaaggu uuacaaccau cuguaggucc caaacaagcu agucuuaaug gagucacauu    20120

aauuggagaa gccguaaaaa cacaguucaa uuauuauaag aaaguugaug guguugucca    20180

acaauuaccu gaaacuuacu uuacucagag uagaaauuua caagaauuua aacccaggag    20240

ucaaauggaa auugauuucu uagaauuagc uauggaugaa uucauugaac gguauaaauu    20300

agaaggcuau gccuucgaac auaucguuua uggagauuuu agucauaguc aguuaggugg    20360

uuuacaucua cugauuggac uagcuaaacg uuuuaaggaa ucaccuuuug aauuagaaga    20420

uuuuauuccu auggacagua caguuaaaaa cuauuucaua acagaugcgc aaacagguuc    20480

aucuaagugu guguguucug uuauugauuu auuacuugau gauuuuguug aaauaauaaa    20540

aucccaagau uuaucuguag uuucuaaggu ugucaaagug acuauugacu auacagaaau    20600

uucauuuaug cuuuggugua aagauggcca uguagaaaca uuuuacccaa aauuacaauc    20660

uagucaagcg uggcaaccgg guguugcuau gccuaaucuu uacaaaaugc aaagaaugcu    20720

auuagaaaag ugugaccuuc aaaauuaugg ugauagugca acauuaccua aaggcauaau    20780

gaugaauguc gcaaaauaua cucaacugug ucaauauuua aacacauuaa cauuagcugu    20840

acccuauaau augagaguua uacauuuugg ugcugguucu gauaaaggag uugcaccagg    20900

uacagcuguu uuaagacagu gguugccuac ggguacgcug cuugucgauu cagaucuuaa    20960

ugacuuuguc ucugaugcag auucaacuuu gauuggugau ugugcaacug uacauacagc    21020

uaauaaaugg gaucucauua uuagugauau guacgacccu aagacuaaaa auguuacaaa    21080

agaaaaugac ucuaaagagg guuuuuucac uuacauuugu ggguuuauac aacaaaagcu    21140

agcucuugga gguuccgugg cuauaaagau aacagaacau ucuuggaaug cugaucuuua    21200

uaagcucaug ggacacuucg caugguggac agccuuuguu acuaauguga augcgucauc    21260

aucugaagca uuuuuaauug gauguaauua ucuuggcaaa ccacgcgaac aaauagaugg    21320

uuaugucaug caugcaaauu acauauuuug gaggaauaca aauccaauuc aguugucuuc    21380

cuauucuuua uuugacauga guaaauuucc ccuuaaauua agggguacug cuguuauguc    21440

uuuaaaagaa ggucaaauca augauaugau uuuaucucuu cuuaguaaag guagacuuau    21500

aauuagagaa aacaacagag uuguuauuuc uagugauguu cuuguuaaca acuaaacgaa    21560

caauguuugu uuuucuuguu uuauugccac uagucucuag ucaguguguu aaucuuacaa    21620

ccagaacuca auuacccccu gcauacacua auucuuucac acgugguguu uauuacccug    21680

acaaaguuuu cagauccuca guuuuacauu caacucagga cuuguucuua ccuuucuuuu    21740

ccaauguuac uugguuccau gcuauacaug ucucugggac caaugguacu aagagguuug    21800

auaacccugu ccuaccauuu aaugauggug uuuauuuugc uuccacugag aagucuaaca    21860

uaauaagagg cuggauuuuu gguacuacuu uagauucgaa gacccagucc cuacuuauug    21920

uuaauaacgc uacuaauguu guuauuaaag ucugugaauu ucaauuuugu aaugauccau    21980

uuuugggugu uuauuaccac aaaaacaaca aaaguuggau ggaaagugag uucagaguuu    22040

auucuagugc gaauaauugc acuuuugaau augucucuca gccuuuucuu auggaccuug    22100

aaggaaaaca ggguaauuuc aaaaaucuua gggaauuugu guuuaagaau auugaugguu    22160

auuuuaaaau auauucuaag cacacgccua uuaauuuagu gcgugaucuc ccucaggguu    22220

uuucggcuuu agaaccauug guagauuugc caauagguau uaacaucacu agguuucaaa    22280

cuuuacuugc uuuacauaga aguuauuuga cuccugguga uucuucuuca gguuggacag    22340

cuggugcugc agcuuauuau guggguuauc uucaaccuag gacuuuucua uuaaaauaua    22400

augaaaaugg aaccauuaca gaugcuguag acugugcacu ugacccucuc ucagaaacaa    22460

aguguacguu gaaauccuuc acuguagaaa aaggaaucua ucaaacuucu aacuuuagag    22520

uccaaccaac agaaucuauu guuagauuuc cuaauauuac aaacuugugc ccuuuuggug    22580

aaguuuuuaa cgccaccaga uuugcaucug uuuaugcuug gaacaggaag agaaucagca    22640

acuguguugc ugauuauucu guccuauaua auuccgcauc auuuuccacu uuuaaguguu    22700

auggaguguc uccuacuaaa uuaaaugauc ucugcuuuac uaaugucuau gcagauucau    22760

uuguaauuag aggugaugaa gucagacaaa ucgcuccagg gcaaacugga aagauugcug    22820

auuauaauua uaaauuacca gaugauuuua caggcugcgu uauagcuugg aauucuaaca    22880

aucuugauuc uaagguuggu gguaauuaua auuaccugua uagauuguuu aggaagucua    22940

aucucaaacc uuuugagaga gauauuucaa cugaaaucua ucaggccggu agcacaccuu    23000

guaauggugu ugaagguuuu aauuguuacu uuccuuuaca aucauauggu uuccaaccca    23060

cuaauggugu ugguuaccaa ccauacagag uaguaguacu uucuuuugaa cuucuacaug    23120

caccagcaac uguuugugga ccuaaaaagu cuacuaauuu gguuaaaaac aaauguguca    23180

auuucaacuu caaugguuua acaggcacag guguucuuac ugagucuaac aaaaaguuuc    23240

ugccuuucca acaauuuggc agagacauug cugacacuac ugaugcuguc cgugauccac    23300

agacacuuga gauucuugac auuacaccau guucuuuugg uggugucagu guuauaacac    23360

caggaacaaa uacuucuaac cagguugcug uucuuuauca ggauguuaac ugcacagaag    23420

ucccuguugc uauucaugca gaucaacuua cuccuacuug gcguguuuau ucuacagguu    23480

cuaauguuuu ucaaacacgu gcaggcuguu uaauaggggc ugaacauguc aacaacucau    23540

augaguguga cauacccauu ggugcaggua uaugcgcuag uuaucagacu cagacuaauu    23600

cuccucggcg ggcacguagu guagcuaguc aauccaucau ugccuacacu augucacuug    23660

gugcagaaaa uucaguugcu uacucuaaua acucuauugc cauacccaca aauuuuacua    23720

uuaguguuac cacagaaauu cuaccagugu cuaugaccaa gacaucagua gauuguacaa    23780

uguacauuug uggugauuca acugaaugca gcaaucuuuu guugcaauau ggcaguuuuu    23840

guacacaauu aaaccgugcu uuaacuggaa uagcuguuga acaagacaaa aacacccaag    23900

aaguuuuugc acaagucaaa caaauuuaca aaacaccacc aauuaaagau uuuggugguu    23960

uuaauuuuuc acaaauauua ccagauccau caaaaccaag caagagguca uuuauugaag    24020

aucuacuuuu caacaaagug acacuugcag augcuggcuu caucaaacaa uauggugauu    24080

gccuugguga uauugcugcu agagaccuca uuugugcaca aaaguuuaac ggccuuacug    24140

uuuugccacc uuugcucaca gaugaaauga uugcucaaua cacuucugca cuguuagcgg    24200

guacaaucac uucugguugg accuuuggug caggugcugc auuacaaaua ccauuugcua    24260

ugcaaauggc uuauagguuu aaugguauug gaguuacaca gaauguucuc uaugagaacc    24320

aaaaauugau ugccaaccaa uuuaauagug cuauuggcaa aauucaagac ucacuuucuu    24380

ccacagcaag ugcacuugga aaacuucaag auguggucaa ccaaaaugca caagcuuuaa    24440

acacgcuugu uaaacaacuu agcuccaauu uuggugcaau uucaaguguu uuaaaugaua    24500

uccuuucacg ucuugacaaa guugaggcug aagugcaaau ugauagguug aucacaggca    24560

gacuucaaag uuugcagaca uaugugacuc aacaauuaau uagagcugca gaaaucagag    24620

cuucugcuaa ucuugcugcu acuaaaaugu cagagugugu acuuggacaa ucaaaaagag    24680

uugauuuuug uggaaagggc uaucaucuua uguccuuccc ucagucagca ccucauggug    24740

uagucuucuu gcaugugacu uaugucccug cacaagaaaa gaacuucaca acugcuccug    24800

ccauuuguca ugauggaaaa gcacacuuuc cucgugaagg ugucuuuguu ucaaauggca    24860

cacacugguu uguaacacaa aggaauuuuu augaaccaca aaucauuacu acagacaaca    24920

cauuuguguc ugguaacugu gauguuguaa uaggaauugu caacaacaca guuuaugauc    24980

cuuugcaacc ugaauuagac ucauucaagg aggaguuaga uaaauauuuu aagaaucaua    25040

caucaccaga uguugauuua ggugacaucu cuggcauuaa ugcuucaguu guaaacauuc    25100

aaaaagaaau ugaccgccuc aaugagguug ccaagaauuu aaaugaaucu cucaucgauc    25160

uccaagaacu uggaaaguau gagcaguaua uaaaauggcc augguacauu uggcuagguu    25220

uuauagcugg cuugauugcc auaguaaugg ugacaauuau gcuuugcugu augaccaguu    25280

gcuguaguug ucucaagggc uguuguucuu guggauccug cugcaaauuu gaugaagacg    25340

acucugagcc agugcucaaa ggagucaaau uacauuacac auaaacgaac uuauggauuu    25400

guuuaugaga aucuucacaa uuggaacugu aacuuugaag caaggugaaa ucaaggaugc    25460

uacuccuuca gauuuuguuc gcgcuacugc aacgauaccg auacaagccu cacucccuuu    25520

cggauggcuu auuguuggcg uugcacuucu ugcuguuuuu cagagcgcuu ccaaaaucau    25580

aacccucaaa aagagauggc aacuagcacu cuccaagggu guucacuuug uuugcaacuu    25640

gcuguuguug uuuguaacag uuuacucaca ccuuuugcuc guugcugcug gccuugaagc    25700

cccuuuucuc uaucuuuaug cuuuagucua cuucuugcag aguauaaacu uuguaagaau    25760

aauaaugagg cuuuggcuuu gcuggaaaug ccguuccaaa aacccauuac uuuaugaugc    25820

caacuauuuu cuuugcuggc auacuaauug uuacgacuau uguauaccuu acaauagugu    25880

aacuucuuca auugucauua cuucagguga uggcacaaca aguccuauuu cugaacauga    25940

cuaccagauu ggugguuaua cugaaaaaug ggaaucugga guaaaagacu guguuguauu    26000

acacaguuac uucacuucag acuauuacca gcuguacuca acucaauuga guacagacac    26060

ugguguugaa cauguuaccu ucuucaucua caauaaaauu guugaugagc cugaagaaca    26120

uguccaaauu cacacaaucg acgguucauc cggaguuguu aauccaguaa uggaaccaau    26180

uuaugaugaa ccgacgacga cuacuagcgu gccuuuguaa gcacaagcug augaguacga    26240

acuuauguac ucauucguuu cggaagagac agguacguua auaguuaaua gcguacuucu    26300

uuuucuugcu uucgugguau ucuugcuagu uacacuagcc auccuuacug cgcuucgauu    26360

gugugcguac ugcugcaaua uuguuaacgu gagucuugua aaaccuucuu uuuacguuua    26420

cucucguguu aaaaaucuga auucuucuag aguuccugau cuucuggucu aaacgaacua    26480

aauauuauau uaguuuuucu guuuggaacu uuaauuuuag ccauggcaga uuccaacggu    26540

acuauuaccg uugaagagcu uaaaaagcuc cuugaacaau ggaaccuagu aauagguuuc    26600

cuauuccuua cauggauuug ucuucuacaa uuugccuaug ccaacaggaa uagguuuuug    26660

uauauaauua aguuaauuuu ccucuggcug uuauggccag uaacuuuagc uuguuuugug    26720

cuugcugcug uuuacagaau aaauuggauc accgguggaa uugcuaucgc aauggcuugu    26780

cuuguaggcu ugauguggcu cagcuacuuc auugcuucuu ucagacuguu ugcgcguacg    26840

cguuccaugu ggucauucaa uccagaaacu aacauucuuc ucaacgugcc acuccauggc    26900

acuauucuga ccagaccgcu ucuagaaagu gaacucguaa ucggagcugu gauccuucgu    26960

ggacaucuuc guauugcugg acaccaucua ggacgcugug acaucaagga ccugccuaaa    27020

gaaaucacug uugcuacauc acgaacgcuu ucuuauuaca aauugggagc uucgcagcgu    27080

guagcaggug acucagguuu ugcugcauac agucgcuaca ggauuggcaa cuauaaauua    27140

aacacagacc auuccaguag cagugacaau auugcuuugc uuguacagua agugacaaca    27200

gauguuucau cucguugacu uucagguuac uauagcagag auauuacuaa uuauuaugag    27260

gacuuuuaaa guuuccauuu ggaaucuuga uuacaucaua aaccucauaa uuaaaaauuu    27320

aucuaaguca cuaacugaga auaaauauuc ucaauuagau gaagagcaac caauggagau    27380

ugauuaaacg aacaugaaaa uuauucuuuu cuuggcacug auaacacucg cuacuuguga    27440

gcuuuaucac uaccaagagu guguuagagg uacaacagua cuuuuaaaag aaccuugcuc    27500

uucuggaaca uacgagggca auucaccauu ucauccucua gcugauaaca aauuugcacu    27560

gacuugcuuu agcacucaau uugcuuuugc uuguccugac ggcguaaaac acgucuauca    27620

guuacgugcc agaucaguuu caccuaaacu guucaucaga caagaggaag uucaagaacu    27680

uuacucucca auuuuucuua uuguugcggc aauaguguuu auaacacuuu gcuucacacu    27740

caaaagaaag acagaaugau ugaacuuuca uuaauugacu ucuauuugug cuuuuuagcc    27800

uuucugcuau uccuuguuuu aauuaugcuu auuaucuuuu gguucucacu ugaacugcaa    27860

gaucauaaug aaacuuguca cgccuaaacg aacaugaaau uucuuguuuu cuuaggaauc    27920

aucacaacug uagcugcauu ucaccaagaa uguaguuuac agucauguac ucaacaucaa    27980

ccauauguag uugaugaccc guguccuauu cacuucuauu cuaaauggua uauuagagua    28040

ggagcuagaa aaucagcacc uuuaauugaa uugugcgugg augaggcugg uucuaaauca    28100

cccauucagu acaucgauau cgguaauuau acaguuuccu guuuaccuuu uacaauuaau    28160

ugccaggaac cuaaauuggg uagucuugua gugcguuguu cguucuauga agacuuuuua    28220

gaguaucaug acguucgugu uguuuuagau uucaucuaaa cgaacaaacu aaaaugucug    28280

auaauggacc ccaaaaucag cgaaaugcac cccgcauuac guuuggugga cccucagauu    28340

caacuggcag uaaccagaau ggagaacgca guggggcgcg aucaaaacaa cgucggcccc    28400

aagguuuacc caauaauacu gcgucuuggu ucaccgcucu cacucaacau ggcaaggaag    28460

accuuaaauu cccucgagga caaggcguuc caauuaacac caauagcagu ccagaugacc    28520

aaauuggcua cuaccgaaga gcuaccagac gaauucgugg uggugacggu aaaaugaaag    28580

aucucagucc aagaugguau uucuacuacc uaggaacugg gccagaagcu ggacuucccu    28640

auggugcuaa caaagacggc aucauauggg uugcaacuga gggagccuug aauacaccaa    28700

aagaucacau uggcacccgc aauccugcua acaaugcugc aaucgugcua caacuuccuc    28760

aaggaacaac auugccaaaa ggcuucuacg cagaagggag cagaggcggc agucaagccu    28820

cuucucguuc cucaucacgu agucgcaaca guucaagaaa uucaacucca ggcagcagua    28880

ggggaacuuc uccugcuaga auggcuggca auggcgguga ugcugcucuu gcuuugcugc    28940

ugcuugacag auugaaccag cuugagagca aaaugucugg uaaaggccaa caacaacaag    29000

gccaaacugu cacuaagaaa ucugcugcug aggcuucuaa gaagccucgg caaaaacgua    29060

cugccacuaa agcauacaau guaacacaag cuuucggcag acguggucca gaacaaaccc    29120

aaggaaauuu uggggaccag gaacuaauca gacaaggaac ugauuacaaa cauuggccgc    29180

aaauugcaca auuugccccc agcgcuucag cguucuucgg aaugucgcgc auuggcaugg    29240

aagucacacc uucgggaacg ugguugaccu acacaggugc caucaaauug gaugacaaag    29300

auccaaauuu caaagaucaa gucauuuugc ugaauaagca uauugacgca uacaaaacau    29360

ucccaccaac agagccuaaa aaggacaaaa agaagaaggc ugaugaaacu caagccuuac    29420

cgcagagaca gaagaaacag caaacuguga cucuucuucc ugcugcagau uuggaugauu    29480

ucuccaaaca auugcaacaa uccaugagca gugcugacuc aacucaggcc uaaacucaug    29540

cagaccacac aaggcagaug ggcuauauaa acguuuucgc uuuuccguuu acgauauaua    29600

gucuacucuu gugcagaaug aauucucgua acuacauagc acaaguagau guaguuaacu    29660

uuaaucucac auagcaaucu uuaaucagug uguaacauua gggaggacuu gaaagagcca    29720

ccacauuuuc accgaggcca cgcggaguac gaucgagugu acagugaaca augcuaggga    29780

gagcugccua uauggaagag cccuaaugug uaaaauuaau uuuaguagug cuauccccau    29840

gugauuuuaa uagcuucuua ggagaaugac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    29900

aaa                                                                  29903


<210>  2
<211>  83
<212>  PRT
<213>  SARS-2 coronavirus

<400>  2

Ser Lys Met Ser Asp Val Lys Cys Thr Ser Val Val Leu Leu Ser Val 
1               5                   10                  15      


Leu Gln Gln Leu Arg Val Glu Ser Ser Ser Lys Leu Trp Ala Gln Cys 
            20                  25                  30          


Val Gln Leu His Asn Asp Ile Leu Leu Ala Lys Asp Thr Thr Glu Ala 
        35                  40                  45              


Phe Glu Lys Met Val Ser Leu Leu Ser Val Leu Leu Ser Met Gln Gly 
    50                  55                  60                  


Ala Val Asp Ile Asn Lys Leu Cys Glu Glu Met Leu Asp Asn Arg Ala 
65                  70                  75                  80  


Thr Leu Gln 
            


<210>  3
<211>  198
<212>  PRT
<213>  SARS-2 coronavirus

<400>  3

Ala Ile Ala Ser Glu Phe Ser Ser Leu Pro Ser Tyr Ala Ala Phe Ala 
1               5                   10                  15      


Thr Ala Gln Glu Ala Tyr Glu Gln Ala Val Ala Asn Gly Asp Ser Glu 
            20                  25                  30          


Val Val Leu Lys Lys Leu Lys Lys Ser Leu Asn Val Ala Lys Ser Glu 
        35                  40                  45              


Phe Asp Arg Asp Ala Ala Met Gln Arg Lys Leu Glu Lys Met Ala Asp 
    50                  55                  60                  


Gln Ala Met Thr Gln Met Tyr Lys Gln Ala Arg Ser Glu Asp Lys Arg 
65                  70                  75                  80  


Ala Lys Val Thr Ser Ala Met Gln Thr Met Leu Phe Thr Met Leu Arg 
                85                  90                  95      


Lys Leu Asp Asn Asp Ala Leu Asn Asn Ile Ile Asn Asn Ala Arg Asp 
            100                 105                 110         


Gly Cys Val Pro Leu Asn Ile Ile Pro Leu Thr Thr Ala Ala Lys Leu 
        115                 120                 125             


Met Val Val Ile Pro Asp Tyr Asn Thr Tyr Lys Asn Thr Cys Asp Gly 
    130                 135                 140                 


Thr Thr Phe Thr Tyr Ala Ser Ala Leu Trp Glu Ile Gln Gln Val Val 
145                 150                 155                 160 


Asp Ala Asp Ser Lys Ile Val Gln Leu Ser Glu Ile Ser Met Asp Asn 
                165                 170                 175     


Ser Pro Asn Leu Ala Trp Pro Leu Ile Val Thr Ala Leu Arg Ala Asn 
            180                 185                 190         


Ser Ala Val Lys Leu Gln 
        195             


<210>  4
<211>  13
<212>  PRT
<213>  SARS-2 coronavirus

<400>  4

Ser Ala Asp Ala Gln Ser Phe Leu Asn Gly Phe Ala Val 
1               5                   10              


<210>  5
<211>  27
<212>  PRT
<213>  SARS-2 coronavirus

<400>  5

Val Gln Pro Val Leu His Arg Ala Ala Gln Ala Leu Val Leu Met Ser 
1               5                   10                  15      


Tyr Thr Gly Leu Leu Thr Ser Thr Met Ile Lys 
            20                  25          


<210>  6
<211>  6
<212>  PRT
<213>  SARS-2 coronavirus

<400>  6

Leu Val Leu Leu Asn Ser 
1               5       


<210>  7
<211>  15
<212>  PRT
<213>  SARS-2 coronavirus

<400>  7

Lys Leu Ile Val Val Ala Ser Lys Lys Arg Thr Lys Met Thr Ile 
1               5                   10                  15  


<210>  8
<211>  5
<212>  PRT
<213>  SARS-2 coronavirus

<400>  8

Leu Ile Leu Thr Leu 
1               5   


<210>  9
<211>  34
<212>  PRT
<213>  SARS-2 coronavirus

<400>  9

Leu Arg Asp Thr Leu Ser Leu Thr Thr Asn Met Lys Lys Gln Phe Ile 
1               5                   10                  15      


Ile Tyr Leu Arg Ile Val Gln Leu Leu Leu Asn Met Thr Ser Leu Ser 
            20                  25                  30          


Leu Glu 
        


<210>  10
<211>  24
<212>  PRT
<213>  SARS-2 coronavirus

<400>  10

Thr Val Thr Trp Tyr His Ile Tyr His Val Asn Val Leu Leu Asn Thr 
1               5                   10                  15      


Gln Trp Gln Thr Ser Ser Met Leu 
            20                  


<210>  11
<211>  10
<212>  PRT
<213>  SARS-2 coronavirus

<400>  11

Gly Ile Leu Met Lys Val Ile Val Thr His 
1               5                   10  


<210>  12
<211>  23
<212>  PRT
<213>  SARS-2 coronavirus

<400>  12

Lys Lys Tyr Leu Ser His Thr Ile Val Val Met Met Ile Ile Ser Ile 
1               5                   10                  15      


Lys Arg Thr Gly Met Ile Leu 
            20              


<210>  13
<211>  11
<212>  PRT
<213>  SARS-2 coronavirus

<400>  13

Lys Thr Gln Ile Tyr Tyr Ala Tyr Thr Pro Thr 
1               5                   10      


<210>  14
<211>  8
<212>  PRT
<213>  SARS-2 coronavirus

<400>  14

Val Asn Val Tyr Ala Lys Leu Cys 
1               5               


<210>  15
<211>  17
<212>  PRT
<213>  SARS-2 coronavirus

<400>  15

Lys Gln Tyr Asn Ser Val Met Pro Cys Glu Met Leu Val Leu Leu Val 
1               5                   10                  15      


Tyr 
    


<210>  16
<211>  26
<212>  PRT
<213>  SARS-2 coronavirus

<400>  16

Ile Ile Lys Ile Ser Met Val Thr Gly Met Ile Ser Val Ile Ser Tyr 
1               5                   10                  15      


Lys Pro Arg Gln Val Val Glu Phe Leu Leu 
            20                  25      


<210>  17
<211>  6
<212>  PRT
<213>  SARS-2 coronavirus

<400>  17

Ile Leu Ile Ile His Cys 
1               5       


<210>  18
<211>  9
<212>  PRT
<213>  SARS-2 coronavirus

<400>  18

Leu Gln Ser His Met Leu Thr Leu Thr 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  SARS-2 coronavirus

<400>  19

Gln Ser Leu Thr Leu Ser Gly Ile Cys 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  SARS-2 coronavirus

<400>  20

Asn Met Thr Ser Arg Lys Arg Gly 
1               5               


<210>  21
<211>  48
<212>  PRT
<213>  SARS-2 coronavirus

<400>  21

Asn Ser Leu Thr Val Ile Leu Asn Ile Gly Ile Arg His Thr Thr Gln 
1               5                   10                  15      


Ile Val Leu Thr Val Trp Met Thr Asp Ala Phe Cys Ile Val Gln Thr 
            20                  25                  30          


Leu Met Phe Tyr Ser Leu Gln Cys Ser His Leu Gln Val Leu Asp His 
        35                  40                  45              


<210>  22
<211>  10
<212>  PRT
<213>  SARS-2 coronavirus

<400>  22

Glu Lys Tyr Leu Leu Met Val Phe His Leu 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  SARS-2 coronavirus

<400>  23

Phe Gln Leu Asp Thr Thr Ser Glu Ser 
1               5                   


<210>  24
<211>  7
<212>  PRT
<213>  SARS-2 coronavirus

<400>  24

Val Leu Tyr Ile Ile Arg Met 
1               5           


<210>  25
<211>  29
<212>  PRT
<213>  SARS-2 coronavirus

<400>  25

Thr Tyr Ile Ala Leu Asp Leu Val Leu Arg Asn Tyr Leu Cys Met Leu 
1               5                   10                  15      


Leu Thr Leu Leu Cys Thr Leu Leu Leu Val Ile Tyr Tyr 
            20                  25                  


<210>  26
<211>  8
<212>  PRT
<213>  SARS-2 coronavirus

<400>  26

Ile Asn Ala Leu Arg Ala Phe Gln 
1               5               


<210>  27
<211>  38
<212>  PRT
<213>  SARS-2 coronavirus

<400>  27

Leu His Leu Leu Thr Met Leu Leu Phe Lys Leu Ser Asn Pro Val Ile 
1               5                   10                  15      


Leu Thr Lys Thr Ser Met Thr Leu Leu Cys Leu Arg Val Ser Leu Arg 
            20                  25                  30          


Lys Glu Val Leu Leu Asn 
        35              


<210>  28
<211>  34
<212>  PRT
<213>  SARS-2 coronavirus

<400>  28

Asn Thr Ser Ser Leu Leu Arg Met Val Met Leu Leu Ser Ala Ile Met 
1               5                   10                  15      


Thr Thr Ile Val Ile Ile Tyr Gln Gln Cys Val Ile Ser Asp Asn Tyr 
            20                  25                  30          


Tyr Leu 
        


<210>  29
<211>  25
<212>  PRT
<213>  SARS-2 coronavirus

<400>  29

Leu Lys Leu Leu Ile Ser Thr Leu Ile Val Thr Met Val Ala Val Leu 
1               5                   10                  15      


Met Leu Thr Lys Ser Ser Ser Thr Thr 
            20                  25  


<210>  30
<211>  20
<212>  PRT
<213>  SARS-2 coronavirus

<400>  30

Thr Asn Gln Leu Val Phe His Leu Ile Asn Gly Val Arg Leu Asp Phe 
1               5                   10                  15      


Ile Met Ile Gln 
            20  


<210>  31
<211>  19
<212>  PRT
<213>  SARS-2 coronavirus

<400>  31

Val Met Arg Ile Lys Met His Phe Ser His Ile Gln Asn Val Met Ser 
1               5                   10                  15      


Ser Leu Leu 
            


<210>  32
<211>  14
<212>  PRT
<213>  SARS-2 coronavirus

<400>  32

Ile Leu Ser Met Pro Leu Val Gln Arg Ile Glu Leu Ala Pro 
1               5                   10                  


<210>  33
<211>  8
<212>  PRT
<213>  SARS-2 coronavirus

<400>  33

Leu Val Ser Leu Ser Val Val Leu 
1               5               


<210>  34
<211>  9
<212>  PRT
<213>  SARS-2 coronavirus

<400>  34

Pro Ile Asp Ser Phe Ile Lys Asn Tyr 
1               5                   


<210>  35
<211>  7
<212>  PRT
<213>  SARS-2 coronavirus

<400>  35

Pro Pro Leu Glu Glu Leu Leu 
1               5           


<210>  36
<211>  13
<212>  PRT
<213>  SARS-2 coronavirus

<400>  36

Leu Glu Gln Ala Asn Ser Met Val Val Gly Thr Thr Cys 
1               5                   10              


<210>  37
<211>  6
<212>  PRT
<213>  SARS-2 coronavirus

<400>  37

Lys Leu Phe Ile Val Met 
1               5       


<210>  38
<211>  45
<212>  PRT
<213>  SARS-2 coronavirus

<400>  38

Lys Thr Leu Thr Leu Trp Val Gly Ile Ile Leu Asn Val Ile Glu Pro 
1               5                   10                  15      


Cys Leu Thr Cys Leu Glu Leu Trp Pro His Leu Phe Leu Leu Ala Asn 
            20                  25                  30          


Ile Gln Arg Val Val Ala Cys His Thr Val Ser Ile Asp 
        35                  40                  45  


<210>  39
<211>  7
<212>  PRT
<213>  SARS-2 coronavirus

<400>  39

Leu Met Ser Val Leu Lys Tyr 
1               5           


<210>  40
<211>  78
<212>  PRT
<213>  SARS-2 coronavirus

<400>  40

Val Lys Trp Ser Cys Val Ala Val His Tyr Met Leu Asn Gln Val Glu 
1               5                   10                  15      


Pro His Gln Glu Met Pro Gln Leu Leu Met Leu Ile Val Phe Leu Thr 
            20                  25                  30          


Phe Val Lys Leu Ser Arg Pro Met Leu Met His Phe Tyr Leu Leu Met 
        35                  40                  45              


Val Thr Lys Leu Pro Ile Ser Met Ser Ala Ile Tyr Asn Thr Asp Phe 
    50                  55                  60                  


Met Ser Val Ser Ile Glu Ile Glu Met Leu Thr Gln Thr Leu 
65                  70                  75              


<210>  41
<211>  12
<212>  PRT
<213>  SARS-2 coronavirus

<400>  41

Met Ser Phe Thr His Ile Cys Val Asn Ile Ser Gln 
1               5                   10          


<210>  42
<211>  18
<212>  PRT
<213>  SARS-2 coronavirus

<400>  42

Tyr Ser Leu Thr Met Leu Leu Cys Val Ser Ile Ala Leu Met His Leu 
1               5                   10                  15      


Lys Val 
        


<210>  43
<211>  39
<212>  PRT
<213>  SARS-2 coronavirus

<400>  43

Arg Thr Leu Ser Gln Phe Phe Ile Ile Lys Thr Met Phe Leu Cys Leu 
1               5                   10                  15      


Lys Gln Asn Val Gly Leu Arg Leu Thr Leu Leu Lys Asp Leu Met Asn 
            20                  25                  30          


Phe Ala Leu Asn Ile Gln Cys 
        35                  


<210>  44
<211>  18
<212>  PRT
<213>  SARS-2 coronavirus

<400>  44

Leu Asn Arg Val Met Ile Met Cys Thr Phe Leu Thr Gln Ile His Gln 
1               5                   10                  15      


Glu Ser 
        


<210>  45
<211>  5
<212>  PRT
<213>  SARS-2 coronavirus

<400>  45

Gly Pro Ala Val Leu 
1               5   


<210>  46
<211>  6
<212>  PRT
<213>  SARS-2 coronavirus

<400>  46

Lys Gln Met Val His Leu 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  SARS-2 coronavirus

<400>  47

Leu Asn Gly Ser Cys Leu 
1               5       


<210>  48
<211>  23
<212>  PRT
<213>  SARS-2 coronavirus

<400>  48

Met Leu Thr His Leu Leu Asn Ile Leu Ile Arg Ser Met Leu Met Ser 
1               5                   10                  15      


Phe Ile Cys Thr Tyr Asn Thr 
            20              


<210>  49
<211>  6
<212>  PRT
<213>  SARS-2 coronavirus

<400>  49

Glu Ser Tyr Met Met Ser 
1               5       


<210>  50
<211>  4
<212>  PRT
<213>  SARS-2 coronavirus

<400>  50

Gln Asp Thr Cys 
1               


<210>  51
<211>  32
<212>  PRT
<213>  SARS-2 coronavirus

<400>  51

Thr Cys Ile Leu Leu Cys Leu Leu Met Ile Thr Leu Gln Gly Ile Gly 
1               5                   10                  15      


Asn Leu Ser Phe Met Arg Leu Cys Thr His Arg Ile Gln Ser Tyr Arg 
            20                  25                  30          


<210>  52
<211>  527
<212>  PRT
<213>  SARS-2 coronavirus

<400>  52

Ala Glu Asn Val Thr Gly Leu Phe Lys Asp Cys Ser Lys Val Ile Thr 
1               5                   10                  15      


Gly Leu His Pro Thr Gln Ala Pro Thr His Leu Ser Val Asp Thr Lys 
            20                  25                  30          


Phe Lys Thr Glu Gly Leu Cys Val Asp Ile Pro Gly Ile Pro Lys Asp 
        35                  40                  45              


Met Thr Tyr Arg Arg Leu Ile Ser Met Met Gly Phe Lys Met Asn Tyr 
    50                  55                  60                  


Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr Arg Glu Glu Ala Ile 
65                  70                  75                  80  


Arg His Val Arg Ala Trp Ile Gly Phe Asp Val Glu Gly Cys His Ala 
                85                  90                  95      


Thr Arg Glu Ala Val Gly Thr Asn Leu Pro Leu Gln Leu Gly Phe Ser 
            100                 105                 110         


Thr Gly Val Asn Leu Val Ala Val Pro Thr Gly Tyr Val Asp Thr Pro 
        115                 120                 125             


Asn Asn Thr Asp Phe Ser Arg Val Ser Ala Lys Pro Pro Pro Gly Asp 
    130                 135                 140                 


Gln Phe Lys His Leu Ile Pro Leu Met Tyr Lys Gly Leu Pro Trp Asn 
145                 150                 155                 160 


Val Val Arg Ile Lys Ile Val Gln Met Leu Ser Asp Thr Leu Lys Asn 
                165                 170                 175     


Leu Ser Asp Arg Val Val Phe Val Leu Trp Ala His Gly Phe Glu Leu 
            180                 185                 190         


Thr Ser Met Lys Tyr Phe Val Lys Ile Gly Pro Glu Arg Thr Cys Cys 
        195                 200                 205             


Leu Cys Asp Arg Arg Ala Thr Cys Phe Ser Thr Ala Ser Asp Thr Tyr 
    210                 215                 220                 


Ala Cys Trp His His Ser Ile Gly Phe Asp Tyr Val Tyr Asn Pro Phe 
225                 230                 235                 240 


Met Ile Asp Val Gln Gln Trp Gly Phe Thr Gly Asn Leu Gln Ser Asn 
                245                 250                 255     


His Asp Leu Tyr Cys Gln Val His Gly Asn Ala His Val Ala Ser Cys 
            260                 265                 270         


Asp Ala Ile Met Thr Arg Cys Leu Ala Val His Glu Cys Phe Val Lys 
        275                 280                 285             


Arg Val Asp Trp Thr Ile Glu Tyr Pro Ile Ile Gly Asp Glu Leu Lys 
    290                 295                 300                 


Ile Asn Ala Ala Cys Arg Lys Val Gln His Met Val Val Lys Ala Ala 
305                 310                 315                 320 


Leu Leu Ala Asp Lys Phe Pro Val Leu His Asp Ile Gly Asn Pro Lys 
                325                 330                 335     


Ala Ile Lys Cys Val Pro Gln Ala Asp Val Glu Trp Lys Phe Tyr Asp 
            340                 345                 350         


Ala Gln Pro Cys Ser Asp Lys Ala Tyr Lys Ile Glu Glu Leu Phe Tyr 
        355                 360                 365             


Ser Tyr Ala Thr His Ser Asp Lys Phe Thr Asp Gly Val Cys Leu Phe 
    370                 375                 380                 


Trp Asn Cys Asn Val Asp Arg Tyr Pro Ala Asn Ser Ile Val Cys Arg 
385                 390                 395                 400 


Phe Asp Thr Arg Val Leu Ser Asn Leu Asn Leu Pro Gly Cys Asp Gly 
                405                 410                 415     


Gly Ser Leu Tyr Val Asn Lys His Ala Phe His Thr Pro Ala Phe Asp 
            420                 425                 430         


Lys Ser Ala Phe Val Asn Leu Lys Gln Leu Pro Phe Phe Tyr Tyr Ser 
        435                 440                 445             


Asp Ser Pro Cys Glu Ser His Gly Lys Gln Val Val Ser Asp Ile Asp 
    450                 455                 460                 


Tyr Val Pro Leu Lys Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly 
465                 470                 475                 480 


Gly Ala Val Cys Arg His His Ala Asn Glu Tyr Arg Leu Tyr Leu Asp 
                485                 490                 495     


Ala Tyr Asn Met Met Ile Ser Ala Gly Phe Ser Leu Trp Val Tyr Lys 
            500                 505                 510         


Gln Phe Asp Thr Tyr Asn Leu Trp Asn Thr Phe Thr Arg Leu Gln 
        515                 520                 525         


<210>  53
<211>  302
<212>  RNA
<213>  SARS-2 coronavirus


<220>
<221>  misc_RNA
<222>  (266)..(301)
<223>  5' portion of ORF1a, nsp1

<400>  53
auuaaagguu uauaccuucc cagguaacaa accaaccaac uuucgaucuc uuguagaucu       60

gcgacucuaa uggucgcuuu aaaaucugug uggcugucac ucggcugcau gcuuagugca      120

cucacgcagu auaauuaaua acuaauuacu gucguugaca ggacacgagu aacucgucua      180

ucuucugcag gcugcuuacg guuucguccg uguugcagcc gaucaucagc acaucuaggu      240

uucguccggg ugugaccgaa agguaagaua gagagccuug ucccugguuu caacgagaaa      300

ac                                                                     302


<210>  54
<211>  229
<212>  RNA
<213>  SARS-2 coronavirus

<400>  54
caaucuuuaa ucagugugua acauuaggga ggacuugaaa gagccaccac auuuucaccg       60

aggccacgcg gaguacgauc gaguguacag ugaacaaugc uagggagagc ugccuauaug      120

gaagagcccu aauguguaaa auuaauuuua guagugcuau ccccauguga uuuuaauagc      180

uucuuaggag aaugacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                  229


<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57
<211>  544
<212>  RNA
<213>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(301)
<223>  5' leader

<220>
<221>  promoter
<222>  (68)..(76)
<223>  Replace endogenous leader TRS with eTRS to prevent recombination 
       with native SARS-2 virus.

<220>
<221>  part of nsp1
<222>  (267)..(301)
<223>  Sequences appended to 5' UTR to match conserved secondary 
       structure of 5' end of coronaviruses

<220>
<221>  misc_feature
<222>  (269)..(269)

<220>
<221>  misc_feature
<222>  (269)..(269)

<220>
<221>  misc_feature
<222>  (302)..(302)
<223>  n

<220>
<221>  promoter
<222>  (306)..(314)
<223>  eTRS

<220>
<221>  misc_RNA
<222>  (315)..(315)
<223>  sgTranscript (subrviral transcript)

<220>
<221>  repeat_region
<222>  (315)..(315)
<223>  Paired subviral promter and the transcript motif can be repeated 
       multiple times here.

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  n

<220>
<221>  3'UTR
<222>  (315)..(544)

<400>  57
auuaaagguu uauaccuucc cagguaacaa accaaccaac uuucgaucuc uuguagaucu       60

guucucuaau ggucgcuuua aaaucugugu ggcugucacu cggcugcaug cuuagugcac      120

ucacgcagua uaauuaauaa cuaauuacug ucguugacag gacacgagua acucgucuau      180

cuucugcagg cugcuuacgg uuucguccgu guugcagccg aucaucagca caucuagguu      240

ucguccgggu gugaccgaaa gguaagauag agagccuugu cccugguuuc aacgagaaaa      300

cnaugaaugg ucgcncaauc uuuaaucagu guguaacauu agggaggacu ugaaagagcc      360

accacauuuu caccgaggcc acgcggagua cgaucgagug uacagugaac aaugcuaggg      420

agagcugccu auauggaaga gcccuaaugu guaaaauuaa uuuuaguagu gcuaucccca      480

ugugauuuua auagcuucuu aggagaauga caaaaaaaaa aaaaaaaaaa aaaaaaaaaa      540

aaaa                                                                   544


<210>  58
<211>  83
<212>  RNA
<213>  synthetic construct

<400>  58
ccccaaaauu uccuuggguu cccaaggaac agcgaaaucg aaggagagga gaggaagagg       60

agaguauuuc gcugauuuug ggg                                               83


<210>  59
<211>  84
<212>  RNA
<213>  synthetic construct

<400>  59
agccuuuugg caauguuguu uacaacauug cguuccucac gaaggagagg agaggaagag       60

gagagugagg aacgagaaga ggcu                                              84


<210>  60
<211>  91
<212>  RNA
<213>  synthetic construct

<400>  60
cguuuagaga acagaucuac uuguagaucu guuuugggac uauucgaagg agaggagagg       60

aagaggagag uagucccaaa aucuuugagc g                                      91


<210>  61
<211>  122
<212>  RNA
<213>  synthetic construct

<400>  61
acacuugcug uggaagaaau uucaaguagu ucuuuucuug ugcagguugg gagacggucg       60

gguccagaua uucguaucug ucgaguagag ugugggcucc caaucugcau gaauagcaag      120

ug                                                                     122


<210>  62
<211>  118
<212>  RNA
<213>  synthetic construct

<400>  62
ucccagagac auguauaggu ucaagucuug ugcauuuugg uugaccggga gacggucggg       60

uccagauauu cguaucuguc gaguagagug ugggcucccg gucaauuucu uuuuggga        118


<210>  63
<211>  109
<212>  RNA
<213>  synthetic construct

<400>  63
agauucauuu aaauucuugg uuccaagaau uaaaaccaag ggagacgguc ggguccagau       60

auucguaucu gucgaguaga gugugggcuc ccuugguuuu gauggaucu                  109


<210>  64
<211>  115
<212>  RNA
<213>  synthetic construct

<400>  64
guuuugaugg aucugguaau uuuaccagau auuggaguuc gggagacggu cggguccaga       60

uauucguauc ugucgaguag agugugggcu cccguaacuc caauaccauu aaacc           115


<210>  65
<211>  118
<212>  RNA
<213>  synthetic construct

<400>  65
ucugagucug auaacuagau ucaaguucug guuguaagau uaacauggag acggucgggu       60

ccagauauuc guaucugucg aguagagugu gggcuccaug uuaguuucug gauugaga        118


<210>  66
<211>  114
<212>  RNA
<213>  synthetic construct

<400>  66
cguuuagaga acagaucuac uuguagaucu guuuugggac uaggagacgg ucggguccag       60

auauucguau cugucgagua gagugugggc uccuaguccc aaaaucuuug agcg            114


<210>  67
<211>  134
<212>  RNA
<213>  synthetic construct

<400>  67
gcacguacga aggagaggag aggaagagga gaguacgugc uuauuggaca ugccgaagga       60

gaggagagga agaggagagg cauguccuua uugggugcau cgaaggagag gagaggaaga      120

ggagagaugc accc                                                        134


<210>  68
<211>  51
<212>  RNA
<213>  synthetic construct

<400>  68
ggagacgguc ggguccagau auucguaucu gucgaguaga gugugggcuc c                51


<210>  69
<211>  26
<212>  RNA
<213>  synthetic construct

<400>  69
cgaaggagag gagaggaaga ggagag                                            26


<210>  70
<211>  146
<212>  RNA
<213>  synthetic construct

<400>  70
uuucggcacg uacgaaggag aggagaggaa gaggagagua cgugcuuauu ggacaugccg       60

aaggagagga gaggaagagg agaggcaugu ccuuauuggg ugcaucgaag gagaggagag      120

gaagaggaga gaugcacccu uuuuaa                                           146


<210>  71
<211>  2758
<212>  RNA
<213>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(302)
<223>  5' leader contains 5' UTR and part of nsp1 needed to maintain 
       conserved secondary structure.

<220>
<221>  promoter
<222>  (69)..(77)
<223>  eTRS

<220>
<221>  misc_feature
<222>  (303)..(1199)
<223>  mCherry proteins cds marker, nucleocapsid aptamer and SARS-2 
       packaging signal.

<220>
<221>  CDS
<222>  (303)..(1013)
<223>  mCherry marker protein

<220>
<221>  misc_binding
<222>  (1030)..(1117)
<223>  SARS-2 Nucleocapsid Aptamer

<220>
<221>  misc_binding
<222>  (1120)..(1199)
<223>  Predicted SARS-2 Packaging Signal. Alignment derived from SARS-1,
       Qin L et al/ Acta Pharmacol Sin 2003 Jun; 24 (6) 489-496

<220>
<221>  misc_RNA
<222>  (1120)..(1199)
<223>  This subviral transcript of 3 MV-RNA is tagged for Mango 
       fluorescence with Mango aptamers embedded within each MV-RNA as 
       well as the (3x) Mango motif.

<220>
<221>  misc_feature
<222>  (1200)..(2368)
<223>  Central RNA region's subviral transcript containing 9 MV-RNA as 
       example.

<220>
<221>  promoter
<222>  (1200)..(1208)
<223>  eTRS

<220>
<221>  promoter
<222>  (1628)..(1636)
<223>  eTRS

<220>
<221>  misc_RNA
<222>  (1628)..(2370)
<223>  This subviral transcript of 5 MV-RNA is tagged for DFHBI 
       fluorescence with Broccoli aptamers embedded within each MV-RNA.

<220>
<221>  3'UTR
<222>  (2530)..(2758)

<400>  71
auuaaagguu uauaccuucc cagguaacaa accaaccaac uuucgaucuc uuguagaucu       60

gcgacucuaa uggucgcuuu aaaaucugug uggcugucac ucggcugcau gcuuagugca      120

cucacgcagu auaauuaaua acuaauuacu gucguugaca ggacacgagu aacucgucua      180

ucuucugcag gcugcuuacg guuucguccg uguugcagcc gaucaucagc acaucuaggu      240

uucguccggg ugugaccgaa agguaagaua gagagccuug ucccugguuu caacgagaaa      300

ac aug gug agc aag ggc gag gag gau aac aug gcc auc auc aag gag         347
   Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu            
   1               5                   10                  15             

uuc aug cgc uuc aag gug cac aug gag ggc ucc gug aac ggc cac gag        395
Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu           
                20                  25                  30                

uuc gag auc gag ggc gag ggc gag ggc cgc ccc uac gag ggc acc cag        443
Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln           
            35                  40                  45                    

acc gcc aag cug aag gug acc aag ggu ggc ccc cug ccc uuc gcc ugg        491
Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp           
        50                  55                  60                        

gac auc cug ucc ccu cag uuc aug uac ggc ucc aag gcc uac gug aag        539
Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys           
    65                  70                  75                            

cac ccc gcc gac auc ccc gac uac uug aag cug ucc uuc ccc gag ggc        587
His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly           
80                  85                  90                  95            

uuc aag ugg gag cgc gug aug aac uuc gag gac ggc ggc gug gug acc        635
Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr           
                100                 105                 110               

gug acc cag gac ucc ucc cua cag gac ggc gag uuc auc uac aag gug        683
Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val           
            115                 120                 125                   

aag cug cgc ggc acc aac uuc ccc ucc gac ggc ccc gua aug cag aag        731
Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys           
        130                 135                 140                       

aag acc aug ggc ugg gag gcc ucc ucc gag cgg aug uac ccc gag gac        779
Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp           
    145                 150                 155                           

ggc gcc cug aag ggc gag auc aag cag agg cug aag cug aag gac ggc        827
Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly           
160                 165                 170                 175           

ggc cac uac gac gcu gag guc aag acc acc uac aag gcc aag aag ccc        875
Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro           
                180                 185                 190               

gug cag cug ccc ggc gcc uac aac guc aac auc aag uug gac auc acc        923
Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr           
            195                 200                 205                   

ucc cac aac gag gac uac acc auc gug gaa cag uac gaa cgc gcc gag        971
Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu           
        210                 215                 220                       

ggc cgc cac ucc acc ggc ggc aug gac gag cug uac aag uag               1013
Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys                       
    225                 230                 235                           

gggcugccgc cggacggcaa ugguacggua cuuccggaug cggaaacugg cuaauuggug     1073

aggcuggggc ggucgugcag caaaagugca cgcuacuuug cuaacuaaaa cuauuucaua     1133

acagaugcgc aaacagguuc aucuaagugu guguguucug uuauugauuu auuacuugau     1193

gauuuuaaug gucgcccuag gaccccaaaa uuuccuuggg uucccaagga acagcgaaau     1253

cgaaggagag gagaggaaga ggagaguauu ucgcugauuu ugggguuuca gccuuuuggc     1313

aauguuguuu acaacauugc guuccucacg aaggagagga gaggaagagg agagugagga     1373

acgagaagag gcuuuuccgu uuagagaaca gaucuacuug uagaucuguu uugggacuau     1433

ucgaaggaga ggagaggaag aggagaguag ucccaaaauc uuugagcguu ucggcacgua     1493

cgaaggagag gagaggaaga ggagaguacg ugcuuauugg acaugccgaa ggagaggaga     1553

ggaagaggag aggcaugucc uuauugggug caucgaagga gaggagagga agaggagaga     1613

ugcacccuuu uuaaaauggu cgcaaacuaa aaacacuugc uguggaagaa auuucaagua     1673

guucuuuucu ugugcagguu gggagacggu cggguccaga uauucguauc ugucgaguag     1733

agugugggcu cccaaucugc augaauagca aguguuucuc ccagagacau guauagguuc     1793

aagucuugug cauuuugguu gaccgggaga cggucggguc cagauauucg uaucugucga     1853

guagagugug ggcucccggu caauuucuuu uugggauuuc agauucauuu aaauucuugg     1913

uuccaagaau uaaaaccaag ggagacgguc ggguccagau auucguaucu gucgaguaga     1973

gugugggcuc ccuugguuuu gauggaucuu uucguuuuga uggaucuggu aauuuuacca     2033

gauauuggag uucgggagac ggucgggucc agauauucgu aucugucgag uagagugugg     2093

gcucccguaa cuccaauacc auuaaaccuu ucucugaguc ugauaacuag auucaaguuc     2153

ugguuguaag auuaacaugg agacggucgg guccagauau ucguaucugu cgaguagagu     2213

gugggcucca uguuaguuuc uggauugaga uuuccguuua gagaacagau cuacuuguag     2273

aucuguuuug ggacuaggag acggucgggu ccagauauuc guaucugucg aguagagugu     2333

gggcuccuag ucccaaaauc uuugagcguu gguaccuaaa cucaugcaga ccacacaagg     2393

cagaugggcu auauaaacgu uuucgcuuuu ccguuuacga uauauagucu acucuugugc     2453

agaaugaauu cucguaacua cauagcacaa guagauguag uuaacuuuaa ucucacauag     2513

cguccggcgg cagccccaau cuuuaaucag uguguaacau uagggaggac uugaaagagc     2573

caccacauuu ucaccgaggc cacgcggagu acgaucgagu guacagugaa caaugcuagg     2633

gagagcugcc uauauggaag agcccuaaug uguaaaauua auuuuaguag ugcuaucccc     2693

augugauuuu aauagcuucu uaggagaaug acaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2753

aaaaa                                                                 2758


<210>  72
<211>  236
<212>  PRT
<213>  synthetic construct

<400>  72

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  73
<211>  10735
<212>  RNA
<213>  Dengue virus


<220>
<221>  5'UTR
<222>  (1)..(94)

<220>
<221>  misc_feature
<222>  (132)..(142)
<223>  Conserved 5' Cyclization motif

<220>
<221>  CDS
<222>  (7574)..(10270)
<223>  RdRp

<220>
<221>  3'UTR
<222>  (10275)..(10735)

<220>
<221>  misc_feature
<222>  (10630)..(10640)
<223>  Conserved 3' Cyclization motif

<400>  73
aguuguuagu cuacguggac cgacaagaac aguuucgaau cggaagcuug cuuaacguag       60

uucuaacagu uuuuuauuag agagcagauc ucugaugaac aaccaacgga aaaagacggg      120

ucgaccgucu uucaauaugc ugaaacgcgc gagaaaccgc gugucaacug uuucacaguu      180

ggcgaagaga uucucaaaag gauugcuuuc aggccaagga cccaugaaau uggugauggc      240

uuuuauagca uuccuaagau uucuagccau accuccaaca gcaggaauuu uggcuagaug      300

gggcucauuc aagaagaaug gagcgaucaa aguguuacgg gguuucaaga aagaaaucuc      360

aaacauguug aacauaauga acaggaggaa aagaucugug accaugcucc ucaugcugcu      420

gcccacagcc cuggcguucc aucugaccac ccgaggggga gagccgcaca ugauaguuag      480

caagcaggaa agaggaaaau cacuuuuguu uaagaccucu gcagguguca acaugugcac      540

ccuuauugca auggauuugg gagaguuaug ugaggacaca augaccuaca aaugcccccg      600

gaucacugag acggaaccag augacguuga cuguuggugc aaugccacgg agacaugggu      660

gaccuaugga acauguucuc aaacugguga acaccgacga gacaaacguu ccgucgcacu      720

ggcaccacac guagggcuug gucuagaaac aagaaccgaa acguggaugu ccucugaagg      780

cgcuuggaaa caaauacaaa aaguggagac cugggcucug agacacccag gauucacggu      840

gauagcccuu uuucuagcac augccauagg aacauccauc acccagaaag ggaucauuuu      900

uauuuugcug augcugguaa cuccauccau ggccaugcgg ugcgugggaa uaggcaacag      960

agacuucgug gaaggacugu caggagcuac guggguggau gugguacugg agcauggaag     1020

uugcgucacu accauggcaa aagacaaacc aacacuggac auugaacucu ugaagacgga     1080

ggucacaaac ccugccgucc ugcgcaaacu gugcauugaa gcuaaaauau caaacaccac     1140

caccgauucg agauguccaa cacaaggaga agccacgcug guggaagaac aggacacgaa     1200

cuuugugugu cgacgaacgu ucguggacag aggcuggggc aaugguugug ggcuauucgg     1260

aaaagguagc uuaauaacgu gugcuaaguu uaagugugug acaaaacugg aaggaaagau     1320

aguccaauau gaaaacuuaa aauauucagu gauagucacc guacacacug gagaccagca     1380

ccaaguugga aaugagacca cagaacaugg aacaacugca accauaacac cucaagcucc     1440

cacgucggaa auacagcuga cagacuacgg agcucuaaca uuggauuguu caccuagaac     1500

agggcuagac uuuaaugaga ugguguuguu gacaaugaaa aaaaaaucau ggcucgucca     1560

caaacaaugg uuucuagacu uaccacugcc uuggaccucg ggggcuucaa caucccaaga     1620

gacuuggaau agacaagacu ugcuggucac auuuaagaca gcucaugcaa aaaagcagga     1680

aguagucgua cuaggaucac aagaaggagc aaugcacacu gcguugacug gagcgacaga     1740

aauccaaacg ucuggaacga caacaauuuu ugcaggacac cugaaaugca gauuaaaaau     1800

ggauaaacug auuuuaaaag ggaugucaua uguaaugugc acagggucau ucaaguuaga     1860

gaaggaagug gcugagaccc agcauggaac uguucuagug cagguuaaau acgaaggaac     1920

agaugcacca ugcaagaucc ccuucucguc ccaagaugag aagggaguaa cccagaaugg     1980

gagauugaua acagccaacc ccauagucac ugacaaagaa aaaccaguca acauugaagc     2040

ggagccaccu uuuggugaga gcuacauugu gguaggagca ggugaaaaag cuuugaaacu     2100

aagcugguuc aagaagggaa gcaguauagg gaaaauguuu gaagcaacug cccguggagc     2160

acgaaggaug gccauccugg gagacacugc augggacuuc gguucuauag gagggguguu     2220

cacgucugug ggaaaacuga uacaccagau uuuugggacu gcguauggag uuuuguucag     2280

cgguguuucu uggaccauga agauaggaau agggauucug cugacauggc uaggauuaaa     2340

cucaaggagc acgucccuuu caaugacgug uaucgcaguu ggcaugguca cacuguaccu     2400

aggagucaug guucaggcgg acucgggaug uguaaucaac uggaaaggca gagaacucaa     2460

auguggaagc ggcauuuuug ucaccaauga aguccacacc uggacagagc aauauaaauu     2520

ccaggccgac uccccuaaga gacuaucagc ggccauuggg aaggcauggg aggagggugu     2580

guguggaauu cgaucagcca cucgucucga gaacaucaug uggaagcaaa uaucaaauga     2640

auuaaaccac aucuuacuug aaaaugacau gaaauuuaca guggucguag gagacguuag     2700

uggaaucuug gcccaaggaa agaaaaugau uaggccacaa cccauggaac acaaauacuc     2760

guggaaaagc uggggaaaag ccaaaaucau aggagcagau guacagaaua ccaccuucau     2820

caucgacggc ccaaacaccc cagaaugccc ugauaaccaa agagcaugga acauuuggga     2880

aguugaagac uauggauuug gaauuuucac gacaaacaua ugguugaaau ugcgugacuc     2940

cuacacucaa gugugugacc accggcuaau gucagcugcc aucaaggaua gcaaagcagu     3000

ccaugcugac augggguacu ggauagaaag ugaaaagaac gagacuugga aguuggcaag     3060

agccuccuuc auagaaguua agacaugcau cuggccaaaa ucccacacuc uauggagcaa     3120

uggaguccug gaaagugaga ugauaauccc aaagauauau ggaggaccaa uaucucagca     3180

caacuacaga ccaggauauu ucacacaaac agcagggccg uggcacuugg gcaaguuaga     3240

acuagauuuu gauuuaugug aagguaccac uguuguugug gaugaacauu guggaaaucg     3300

aggaccaucu cuuagaacca caacagucac aggaaagaca auccaugaau ggugcuguag     3360

aucuugcacg uuaccccccc uacguuucaa aggagaagac gggugcuggu acggcaugga     3420

aaucagacca gucaaggaga aggaagagaa ccuaguuaag ucaauggucu cugcaggguc     3480

aggagaagug gacaguuuuu cacuaggacu gcuaugcaua ucaauaauga ucgaagaggu     3540

aaugagaucc agauggagca gaaaaaugcu gaugacugga acauuggcug uguuccuccu     3600

ucucacaaug ggacaauuga cauggaauga ucugaucagg cuauguauca ugguuggagc     3660

caacgcuuca gacaagaugg ggaugggaac aacguaccua gcuuugaugg ccacuuucag     3720

aaugagacca auguucgcag ucgggcuacu guuucgcaga uuaacaucua gagaaguucu     3780

ucuucuuaca guuggauuga gucugguggc aucuguagaa cuaccaaauu ccuuagagga     3840

gcuaggggau ggacuugcaa ugggcaucau gauguugaaa uuacugacug auuuucaguc     3900

acaucagcua ugggcuaccu ugcugucuuu aacauuuguc aaaacaacuu uuucauugca     3960

cuaugcaugg aagacaaugg cuaugauacu gucaauugua ucucucuucc cuuuaugccu     4020

guccacgacu ucucaaaaaa caacauggcu uccgguguug cugggaucuc uuggaugcaa     4080

accacuaacc auguuucuua uaacagaaaa caaaaucugg ggaaggaaaa gcuggccucu     4140

caaugaagga auuauggcug uuggaauagu uagcauucuu cuaaguucac uucucaagaa     4200

ugaugugcca cuagcuggcc cacuaauagc uggaggcaug cuaauagcau guuaugucau     4260

aucuggaagc ucggccgauu uaucacugga gaaagcggcu gaggucuccu gggaagaaga     4320

agcagaacac ucuggugccu cacacaacau acuaguggag guccaagaug auggaaccau     4380

gaagauaaag gaugaagaga gagaugacac acucaccauu cuccucaaag caacucugcu     4440

agcaaucuca gggguauacc caaugucaau accggcgacc cucuuugugu gguauuuuug     4500

gcagaaaaag aaacagagau caggagugcu augggacaca cccagcccuc cagaagugga     4560

aagagcaguc cuugaugaug gcauuuauag aauucuccaa agaggauugu ugggcagguc     4620

ucaaguagga guaggaguuu uucaagaagg cguguuccac acaauguggc acgucaccag     4680

gggagcuguc cucauguacc aagggaagag acuggaacca aguugggcca gugucaaaaa     4740

agacuugauc ucauauggag gagguuggag guuucaagga uccuggaacg cgggagaaga     4800

agugcaggug auugcuguug aaccggggaa gaaccccaaa aauguacaga cagcgccggg     4860

uaccuucaag accccugaag gcgaaguugg agccauagcu cuagacuuua aacccggcac     4920

aucuggaucu ccuaucguga acagagaggg aaaaauagua ggucuuuaug gaaauggagu     4980

ggugacaaca agugguaccu acgucagugc cauagcucaa gcuaaagcau cacaagaagg     5040

gccucuacca gagauugagg acgagguguu uaggaaaaga aacuuaacaa uaauggaccu     5100

acauccagga ucgggaaaaa caagaagaua ccuuccagcc auaguccgug aggccauaaa     5160

aagaaagcug cgcacgcuag ucuuagcucc cacaagaguu gucgcuucug aaauggcaga     5220

ggcgcucaag ggaaugccaa uaagguauca gacaacagca gugaagagug aacacacggg     5280

aaaggagaua guugaccuua ugugucacgc cacuuucacu augcgucucc ugucuccugu     5340

gagaguuccc aauuauaaua ugauuaucau ggaugaagca cauuuuaccg auccagccag     5400

cauagcagcc agaggguaua ucucaacccg aguggguaug ggugaagcag cugcgauuuu     5460

caugacagcc acuccccccg gaucggugga ggccuuucca cagagcaaug caguuaucca     5520

agaugaggaa agagacauuc cugaaagauc auggaacuca ggcuaugacu ggaucacuga     5580

uuucccaggu aaaacagucu gguuuguucc aagcaucaaa ucaggaaaug acauugccaa     5640

cuguuuaaga aagaauggga aacggguggu ccaauugagc agaaaaacuu uugacacuga     5700

guaccagaaa acaaaaaaua acgacuggga cuauguuguc acaacagaca uauccgaaau     5760

gggagcaaac uuccgagccg acaggguaau agacccgagg cggugccuga aaccgguaau     5820

acuaaaagau ggcccagagc gugucauucu agccggaccg augccaguga cuguggcuag     5880

cgccgcccag aggagaggaa gaauuggaag gaaccaaaau aaggaaggcg aucaguauau     5940

uuacauggga cagccucuaa acaaugauga ggaccacgcc cauuggacag aagcaaaaau     6000

gcuccuugac aacauaaaca caccagaagg gauuauccca gcccucuuug agccggagag     6060

agaaaagagu gcagcaauag acggggaaua cagacuacgg ggugaagcga ggaaaacguu     6120

cguggagcuc augagaagag gagaucuacc ugucuggcua uccuacaaag uugccucaga     6180

aggcuuccag uacuccgaca gaagguggug cuuugauggg gaaaggaaca accagguguu     6240

ggaggagaac auggacgugg agaucuggac aaaagaagga gaaagaaaga aacuacgacc     6300

ccgcuggcug gaugccagaa cauacucuga cccacuggcu cugcgcgaau ucaaagaguu     6360

cgcagcagga agaagaagcg ucucagguga ccuaauauua gaaauaggga aacuuccaca     6420

acauuuaacg caaagggccc agaacgccuu ggacaaucug guuauguugc acaacucuga     6480

acaaggagga aaagccuaua gacacgccau ggaagaacua ccagacacca uagaaacguu     6540

aaugcuccua gcuuugauag cugugcugac ugguggagug acguuguucu uccuaucagg     6600

aaggggucua ggaaaaacau ccauuggccu acucugcgug auugccucaa gugcacuguu     6660

auggauggcc aguguggaac cccauuggau agcggccucu aucauacugg aguucuuucu     6720

gaugguguug cuuauuccag agccggacag acagcgcacu ccacaagaca accagcuagc     6780

auacguggug auaggucugu uauucaugau auugacagug gcagccaaug agaugggauu     6840

acuggaaacc acaaagaagg accuggggau uggucaugca gcugcugaaa accaccauca     6900

ugcugcaaug cuggacguag accuacaucc agcuucagcc uggacucucu augcaguggc     6960

cacaacaauu aucacuccca ugaugagaca cacaauugaa aacacaacgg caaauauuuc     7020

ccugacagcu auugcaaacc aggcagcuau auugauggga cuugacaagg gauggccaau     7080

aucaaagaug gacauaggag uuccacuucu cgccuugggg ugcuauucuc aggugaaccc     7140

gcugacgcug acagcggcgg uauugaugcu aguggcucau uaugccauaa uuggacccgg     7200

acugcaagca aaagcuacua gagaagcuca aaaaaggaca gcagccggaa uaaugaaaaa     7260

cccaacuguc gacgggaucg uugcaauaga uuuggacccu gugguuuacg augcaaaauu     7320

ugaaaaacag cuaggccaaa uaauguuguu gauacuuugc acaucacaga uccuccugau     7380

gcggaccaca ugggccuugu gugaauccau cacacuagcc acuggaccuc ugacuacgcu     7440

uugggaggga ucuccaggaa aauucuggaa caccacgaua gcggugucca uggcaaacau     7500

uuuuagggga aguuaucuag caggagcagg ucuggccuuu ucauuaauga aaucucuagg     7560

aggagguagg aga ggc acg gga gcc caa ggg gaa aca cug gga gaa aaa        7609
               Gly Thr Gly Ala Gln Gly Glu Thr Leu Gly Glu Lys            
               1               5                   10                     

ugg aaa aga cag cua aac caa uug agc aag uca gaa uuc aac acu uac       7657
Trp Lys Arg Gln Leu Asn Gln Leu Ser Lys Ser Glu Phe Asn Thr Tyr           
        15                  20                  25                        

aaa agg agu ggg auu aua gag gug gau aga ucu gaa gcc aaa gag ggg       7705
Lys Arg Ser Gly Ile Ile Glu Val Asp Arg Ser Glu Ala Lys Glu Gly           
    30                  35                  40                            

uua aaa aga gga gaa acg acu aaa cac gca gug ucg aga gga acg gcc       7753
Leu Lys Arg Gly Glu Thr Thr Lys His Ala Val Ser Arg Gly Thr Ala           
45                  50                  55                  60            

aaa cug agg ugg uuu gug gag agg aac cuu gug aaa cca gaa ggg aaa       7801
Lys Leu Arg Trp Phe Val Glu Arg Asn Leu Val Lys Pro Glu Gly Lys           
                65                  70                  75                

guc aua gac cuc ggu ugu gga aga ggu ggc ugg uca uau uau ugc gcu       7849
Val Ile Asp Leu Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr Cys Ala           
            80                  85                  90                    

ggg cug aag aaa guc aca gaa gug aaa gga uac acg aaa gga gga ccu       7897
Gly Leu Lys Lys Val Thr Glu Val Lys Gly Tyr Thr Lys Gly Gly Pro           
        95                  100                 105                       

gga cau gag gaa cca auc cca aug gca acc uau gga ugg aac cua gua       7945
Gly His Glu Glu Pro Ile Pro Met Ala Thr Tyr Gly Trp Asn Leu Val           
    110                 115                 120                           

aag cua uac ucc ggg aaa gau gua uuc uuu aca cca ccu gag aaa ugu       7993
Lys Leu Tyr Ser Gly Lys Asp Val Phe Phe Thr Pro Pro Glu Lys Cys           
125                 130                 135                 140           

gac acc cuc uug ugu gau auu ggu gag ucc ucu ccg aac cca acu aua       8041
Asp Thr Leu Leu Cys Asp Ile Gly Glu Ser Ser Pro Asn Pro Thr Ile           
                145                 150                 155               

gaa gaa gga aga acg uua cgu guu cua aag aug gug gaa cca ugg cuc       8089
Glu Glu Gly Arg Thr Leu Arg Val Leu Lys Met Val Glu Pro Trp Leu           
            160                 165                 170                   

aga gga aac caa uuu ugc aua aaa auu cua aau ccc uau aug ccg agu       8137
Arg Gly Asn Gln Phe Cys Ile Lys Ile Leu Asn Pro Tyr Met Pro Ser           
        175                 180                 185                       

gug gua gaa acu uug gag caa aug caa aga aaa cau gga gga aug cua       8185
Val Val Glu Thr Leu Glu Gln Met Gln Arg Lys His Gly Gly Met Leu           
    190                 195                 200                           

gug cga aau cca cuc uca aga aac ucc acu cau gaa aug uac ugg guu       8233
Val Arg Asn Pro Leu Ser Arg Asn Ser Thr His Glu Met Tyr Trp Val           
205                 210                 215                 220           

uca ugu gga aca gga aac auu gug uca gca gua aac aug aca ucu aga       8281
Ser Cys Gly Thr Gly Asn Ile Val Ser Ala Val Asn Met Thr Ser Arg           
                225                 230                 235               

aug cug cua aau cga uuc aca aug gcu cac agg aag cca aca uau gaa       8329
Met Leu Leu Asn Arg Phe Thr Met Ala His Arg Lys Pro Thr Tyr Glu           
            240                 245                 250                   

aga gac gug gac uua ggc gcu gga aca aga cau gug gca gua gaa cca       8377
Arg Asp Val Asp Leu Gly Ala Gly Thr Arg His Val Ala Val Glu Pro           
        255                 260                 265                       

gag gug gcc aac cua gau auc auu ggc cag agg aua gag aau aua aaa       8425
Glu Val Ala Asn Leu Asp Ile Ile Gly Gln Arg Ile Glu Asn Ile Lys           
    270                 275                 280                           

aau gaa cac aaa uca aca ugg cau uau gau gag gac aau cca uac aaa       8473
Asn Glu His Lys Ser Thr Trp His Tyr Asp Glu Asp Asn Pro Tyr Lys           
285                 290                 295                 300           

aca ugg gcc uau cau gga uca uau gag guc aag cca uca gga uca gcc       8521
Thr Trp Ala Tyr His Gly Ser Tyr Glu Val Lys Pro Ser Gly Ser Ala           
                305                 310                 315               

uca ucc aug guc aau ggu gug gug aga cug cua acc aaa cca ugg gau       8569
Ser Ser Met Val Asn Gly Val Val Arg Leu Leu Thr Lys Pro Trp Asp           
            320                 325                 330                   

guc auu ccc aug guc aca caa aua gcc aug acu gac acc aca ccc uuu       8617
Val Ile Pro Met Val Thr Gln Ile Ala Met Thr Asp Thr Thr Pro Phe           
        335                 340                 345                       

gga caa cag agg gug uuu aaa gag aaa guu gac acg cgu aca cca aaa       8665
Gly Gln Gln Arg Val Phe Lys Glu Lys Val Asp Thr Arg Thr Pro Lys           
    350                 355                 360                           

gcg aaa cga ggc aca gca caa auu aug gag gug aca gcc agg ugg uua       8713
Ala Lys Arg Gly Thr Ala Gln Ile Met Glu Val Thr Ala Arg Trp Leu           
365                 370                 375                 380           

ugg ggu uuu cuc ucu aga aac aaa aaa ccc aga auc ugc aca aga gag       8761
Trp Gly Phe Leu Ser Arg Asn Lys Lys Pro Arg Ile Cys Thr Arg Glu           
                385                 390                 395               

gag uuc aca aga aaa guc agg uca aac gca gcu auu gga gca gug uuc       8809
Glu Phe Thr Arg Lys Val Arg Ser Asn Ala Ala Ile Gly Ala Val Phe           
            400                 405                 410                   

guu gau gaa aau caa ugg aac uca gca aaa gag gca gug gaa gau gaa       8857
Val Asp Glu Asn Gln Trp Asn Ser Ala Lys Glu Ala Val Glu Asp Glu           
        415                 420                 425                       

cgg uuc ugg gac cuu gug cac aga gag agg gag cuu cau aaa caa gga       8905
Arg Phe Trp Asp Leu Val His Arg Glu Arg Glu Leu His Lys Gln Gly           
    430                 435                 440                           

aaa ugu gcc acg ugu guc uac aac aug aug gga aag aga gag aaa aaa       8953
Lys Cys Ala Thr Cys Val Tyr Asn Met Met Gly Lys Arg Glu Lys Lys           
445                 450                 455                 460           

uua gga gag uuc gga aag gca aaa gga agu cgc gca aua ugg uac aug       9001
Leu Gly Glu Phe Gly Lys Ala Lys Gly Ser Arg Ala Ile Trp Tyr Met           
                465                 470                 475               

ugg uug gga gcg cgc uuu uua gag uuu gaa gcc cuu ggu uuc aug aau       9049
Trp Leu Gly Ala Arg Phe Leu Glu Phe Glu Ala Leu Gly Phe Met Asn           
            480                 485                 490                   

gaa gau cac ugg uuc agc aga gag aau uca cuc agu gga gug gaa gga       9097
Glu Asp His Trp Phe Ser Arg Glu Asn Ser Leu Ser Gly Val Glu Gly           
        495                 500                 505                       

gaa gga cuc cac aaa cuu gga uac aua cuc aga gac aua uca aag auu       9145
Glu Gly Leu His Lys Leu Gly Tyr Ile Leu Arg Asp Ile Ser Lys Ile           
    510                 515                 520                           

cca ggg gga aau aug uau gca gau gac aca gcc gga ugg gac aca aga       9193
Pro Gly Gly Asn Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg           
525                 530                 535                 540           

aua aca gag gau gau cuu cag aau gag gcc aaa auc acu gac auc aug       9241
Ile Thr Glu Asp Asp Leu Gln Asn Glu Ala Lys Ile Thr Asp Ile Met           
                545                 550                 555               

gaa ccu gaa cau gcc cua uug gcc acg uca auc uuu aag cua acc uac       9289
Glu Pro Glu His Ala Leu Leu Ala Thr Ser Ile Phe Lys Leu Thr Tyr           
            560                 565                 570                   

caa aac aag gua gua agg gug cag aga cca gcg aaa aau gga acc gug       9337
Gln Asn Lys Val Val Arg Val Gln Arg Pro Ala Lys Asn Gly Thr Val           
        575                 580                 585                       

aug gau guc aua ucc aga cgu gac cag aga gga agu gga cag guu gga       9385
Met Asp Val Ile Ser Arg Arg Asp Gln Arg Gly Ser Gly Gln Val Gly           
    590                 595                 600                           

acc uau ggc uua aac acc uuc acc aac aug gag gcc caa cua aua aga       9433
Thr Tyr Gly Leu Asn Thr Phe Thr Asn Met Glu Ala Gln Leu Ile Arg           
605                 610                 615                 620           

caa aug gag ucu gag gga auc uuu uca ccc agc gaa uug gaa acc cca       9481
Gln Met Glu Ser Glu Gly Ile Phe Ser Pro Ser Glu Leu Glu Thr Pro           
                625                 630                 635               

aau cua gcc gaa aga guc cuc gac ugg uug aaa aaa cau ggc acc gag       9529
Asn Leu Ala Glu Arg Val Leu Asp Trp Leu Lys Lys His Gly Thr Glu           
            640                 645                 650                   

agg cug aaa aga aug gca auc agu gga gau gac ugu gug gug aaa cca       9577
Arg Leu Lys Arg Met Ala Ile Ser Gly Asp Asp Cys Val Val Lys Pro           
        655                 660                 665                       

auc gau gac aga uuu gca aca gcc uua aca gcu uug aau gac aug gga       9625
Ile Asp Asp Arg Phe Ala Thr Ala Leu Thr Ala Leu Asn Asp Met Gly           
    670                 675                 680                           

aag gua aga aaa gac aua ccg caa ugg gaa ccu uca aaa gga ugg aau       9673
Lys Val Arg Lys Asp Ile Pro Gln Trp Glu Pro Ser Lys Gly Trp Asn           
685                 690                 695                 700           

gau ugg caa caa gug ccu uuc ugu uca cac cau uuc cac cag cug auu       9721
Asp Trp Gln Gln Val Pro Phe Cys Ser His His Phe His Gln Leu Ile           
                705                 710                 715               

aug aag gau ggg agg gag aua gug gug cca ugc cgc aac caa gau gaa       9769
Met Lys Asp Gly Arg Glu Ile Val Val Pro Cys Arg Asn Gln Asp Glu           
            720                 725                 730                   

cuu gua ggu agg gcc aga gua uca caa ggc gcc gga ugg agc uug aga       9817
Leu Val Gly Arg Ala Arg Val Ser Gln Gly Ala Gly Trp Ser Leu Arg           
        735                 740                 745                       

gaa acu gca ugc cua ggc aag uca uau gca caa aug ugg cag cug aug       9865
Glu Thr Ala Cys Leu Gly Lys Ser Tyr Ala Gln Met Trp Gln Leu Met           
    750                 755                 760                           

uac uuc cac agg aga gac uug aga uua gcg gcu aau gcu auc ugu uca       9913
Tyr Phe His Arg Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys Ser           
765                 770                 775                 780           

gcc guu cca guu gau ugg guc cca acc agc cgc acc acc ugg ucg auc       9961
Ala Val Pro Val Asp Trp Val Pro Thr Ser Arg Thr Thr Trp Ser Ile           
                785                 790                 795               

cau gcc cac cau caa ugg aug aca aca gaa gac aug uug uca gug ugg      10009
His Ala His His Gln Trp Met Thr Thr Glu Asp Met Leu Ser Val Trp           
            800                 805                 810                   

aau agg guu ugg aua gag gaa aac cca ugg aug gag gac aag acu cau      10057
Asn Arg Val Trp Ile Glu Glu Asn Pro Trp Met Glu Asp Lys Thr His           
        815                 820                 825                       

gug ucc agu ugg gaa gac guu cca uac cua gga aaa agg gaa gau caa      10105
Val Ser Ser Trp Glu Asp Val Pro Tyr Leu Gly Lys Arg Glu Asp Gln           
    830                 835                 840                           

ugg ugu ggu ucc cua aua ggc uua aca gca cga gcc acc ugg gcc acc      10153
Trp Cys Gly Ser Leu Ile Gly Leu Thr Ala Arg Ala Thr Trp Ala Thr           
845                 850                 855                 860           

aac aua caa gug gcc aua aac caa gug aga agg cuc auu ggg aau gag      10201
Asn Ile Gln Val Ala Ile Asn Gln Val Arg Arg Leu Ile Gly Asn Glu           
                865                 870                 875               

aau uau cua gac uuc aug aca uca aug aag aga uuc aaa aac gag agu      10249
Asn Tyr Leu Asp Phe Met Thr Ser Met Lys Arg Phe Lys Asn Glu Ser           
            880                 885                 890                   

gau ccc gaa ggg gca cuc ugg uaagccaacu cauucacaaa auaaaggaaa         10300
Asp Pro Glu Gly Ala Leu Trp                                               
        895                                                               

auaaaaaauc aaacaaggca agaagucagg ccggauuaag ccauagcacg guaagagcua    10360

ugcugccugu gagccccguc caaggacgua aaaugaaguc aggccgaaag ccacgguucg    10420

agcaagccgu gcugccugua gcuccaucgu ggggauguaa aaacccggga ggcugcaaac    10480

cauggaagcu guacgcaugg gguagcagac uagugguuag aggagacccc ucccaagaca    10540

caacgcagca gcggggccca acaccagggg aagcuguacc cuggugguaa ggacuagagg    10600

uuagaggaga ccccccgcac aacaacaaac agcauauuga cgcugggaga gaccagagau    10660

ccugcugucu cuacagcauc auuccaggca cagaacgcca aaaaauggaa uggugcuguu    10720

gaaucaacag guucu                                                     10735


<210>  74
<211>  899
<212>  PRT
<213>  Dengue virus

<400>  74

Gly Thr Gly Ala Gln Gly Glu Thr Leu Gly Glu Lys Trp Lys Arg Gln 
1               5                   10                  15      


Leu Asn Gln Leu Ser Lys Ser Glu Phe Asn Thr Tyr Lys Arg Ser Gly 
            20                  25                  30          


Ile Ile Glu Val Asp Arg Ser Glu Ala Lys Glu Gly Leu Lys Arg Gly 
        35                  40                  45              


Glu Thr Thr Lys His Ala Val Ser Arg Gly Thr Ala Lys Leu Arg Trp 
    50                  55                  60                  


Phe Val Glu Arg Asn Leu Val Lys Pro Glu Gly Lys Val Ile Asp Leu 
65                  70                  75                  80  


Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr Cys Ala Gly Leu Lys Lys 
                85                  90                  95      


Val Thr Glu Val Lys Gly Tyr Thr Lys Gly Gly Pro Gly His Glu Glu 
            100                 105                 110         


Pro Ile Pro Met Ala Thr Tyr Gly Trp Asn Leu Val Lys Leu Tyr Ser 
        115                 120                 125             


Gly Lys Asp Val Phe Phe Thr Pro Pro Glu Lys Cys Asp Thr Leu Leu 
    130                 135                 140                 


Cys Asp Ile Gly Glu Ser Ser Pro Asn Pro Thr Ile Glu Glu Gly Arg 
145                 150                 155                 160 


Thr Leu Arg Val Leu Lys Met Val Glu Pro Trp Leu Arg Gly Asn Gln 
                165                 170                 175     


Phe Cys Ile Lys Ile Leu Asn Pro Tyr Met Pro Ser Val Val Glu Thr 
            180                 185                 190         


Leu Glu Gln Met Gln Arg Lys His Gly Gly Met Leu Val Arg Asn Pro 
        195                 200                 205             


Leu Ser Arg Asn Ser Thr His Glu Met Tyr Trp Val Ser Cys Gly Thr 
    210                 215                 220                 


Gly Asn Ile Val Ser Ala Val Asn Met Thr Ser Arg Met Leu Leu Asn 
225                 230                 235                 240 


Arg Phe Thr Met Ala His Arg Lys Pro Thr Tyr Glu Arg Asp Val Asp 
                245                 250                 255     


Leu Gly Ala Gly Thr Arg His Val Ala Val Glu Pro Glu Val Ala Asn 
            260                 265                 270         


Leu Asp Ile Ile Gly Gln Arg Ile Glu Asn Ile Lys Asn Glu His Lys 
        275                 280                 285             


Ser Thr Trp His Tyr Asp Glu Asp Asn Pro Tyr Lys Thr Trp Ala Tyr 
    290                 295                 300                 


His Gly Ser Tyr Glu Val Lys Pro Ser Gly Ser Ala Ser Ser Met Val 
305                 310                 315                 320 


Asn Gly Val Val Arg Leu Leu Thr Lys Pro Trp Asp Val Ile Pro Met 
                325                 330                 335     


Val Thr Gln Ile Ala Met Thr Asp Thr Thr Pro Phe Gly Gln Gln Arg 
            340                 345                 350         


Val Phe Lys Glu Lys Val Asp Thr Arg Thr Pro Lys Ala Lys Arg Gly 
        355                 360                 365             


Thr Ala Gln Ile Met Glu Val Thr Ala Arg Trp Leu Trp Gly Phe Leu 
    370                 375                 380                 


Ser Arg Asn Lys Lys Pro Arg Ile Cys Thr Arg Glu Glu Phe Thr Arg 
385                 390                 395                 400 


Lys Val Arg Ser Asn Ala Ala Ile Gly Ala Val Phe Val Asp Glu Asn 
                405                 410                 415     


Gln Trp Asn Ser Ala Lys Glu Ala Val Glu Asp Glu Arg Phe Trp Asp 
            420                 425                 430         


Leu Val His Arg Glu Arg Glu Leu His Lys Gln Gly Lys Cys Ala Thr 
        435                 440                 445             


Cys Val Tyr Asn Met Met Gly Lys Arg Glu Lys Lys Leu Gly Glu Phe 
    450                 455                 460                 


Gly Lys Ala Lys Gly Ser Arg Ala Ile Trp Tyr Met Trp Leu Gly Ala 
465                 470                 475                 480 


Arg Phe Leu Glu Phe Glu Ala Leu Gly Phe Met Asn Glu Asp His Trp 
                485                 490                 495     


Phe Ser Arg Glu Asn Ser Leu Ser Gly Val Glu Gly Glu Gly Leu His 
            500                 505                 510         


Lys Leu Gly Tyr Ile Leu Arg Asp Ile Ser Lys Ile Pro Gly Gly Asn 
        515                 520                 525             


Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile Thr Glu Asp 
    530                 535                 540                 


Asp Leu Gln Asn Glu Ala Lys Ile Thr Asp Ile Met Glu Pro Glu His 
545                 550                 555                 560 


Ala Leu Leu Ala Thr Ser Ile Phe Lys Leu Thr Tyr Gln Asn Lys Val 
                565                 570                 575     


Val Arg Val Gln Arg Pro Ala Lys Asn Gly Thr Val Met Asp Val Ile 
            580                 585                 590         


Ser Arg Arg Asp Gln Arg Gly Ser Gly Gln Val Gly Thr Tyr Gly Leu 
        595                 600                 605             


Asn Thr Phe Thr Asn Met Glu Ala Gln Leu Ile Arg Gln Met Glu Ser 
    610                 615                 620                 


Glu Gly Ile Phe Ser Pro Ser Glu Leu Glu Thr Pro Asn Leu Ala Glu 
625                 630                 635                 640 


Arg Val Leu Asp Trp Leu Lys Lys His Gly Thr Glu Arg Leu Lys Arg 
                645                 650                 655     


Met Ala Ile Ser Gly Asp Asp Cys Val Val Lys Pro Ile Asp Asp Arg 
            660                 665                 670         


Phe Ala Thr Ala Leu Thr Ala Leu Asn Asp Met Gly Lys Val Arg Lys 
        675                 680                 685             


Asp Ile Pro Gln Trp Glu Pro Ser Lys Gly Trp Asn Asp Trp Gln Gln 
    690                 695                 700                 


Val Pro Phe Cys Ser His His Phe His Gln Leu Ile Met Lys Asp Gly 
705                 710                 715                 720 


Arg Glu Ile Val Val Pro Cys Arg Asn Gln Asp Glu Leu Val Gly Arg 
                725                 730                 735     


Ala Arg Val Ser Gln Gly Ala Gly Trp Ser Leu Arg Glu Thr Ala Cys 
            740                 745                 750         


Leu Gly Lys Ser Tyr Ala Gln Met Trp Gln Leu Met Tyr Phe His Arg 
        755                 760                 765             


Arg Asp Leu Arg Leu Ala Ala Asn Ala Ile Cys Ser Ala Val Pro Val 
    770                 775                 780                 


Asp Trp Val Pro Thr Ser Arg Thr Thr Trp Ser Ile His Ala His His 
785                 790                 795                 800 


Gln Trp Met Thr Thr Glu Asp Met Leu Ser Val Trp Asn Arg Val Trp 
                805                 810                 815     


Ile Glu Glu Asn Pro Trp Met Glu Asp Lys Thr His Val Ser Ser Trp 
            820                 825                 830         


Glu Asp Val Pro Tyr Leu Gly Lys Arg Glu Asp Gln Trp Cys Gly Ser 
        835                 840                 845             


Leu Ile Gly Leu Thr Ala Arg Ala Thr Trp Ala Thr Asn Ile Gln Val 
    850                 855                 860                 


Ala Ile Asn Gln Val Arg Arg Leu Ile Gly Asn Glu Asn Tyr Leu Asp 
865                 870                 875                 880 


Phe Met Thr Ser Met Lys Arg Phe Lys Asn Glu Ser Asp Pro Glu Gly 
                885                 890                 895     


Ala Leu Trp 
            


<210>  75
<211>  147
<212>  RNA
<213>  Dengue virus


<220>
<221>  promoter
<222>  (132)..(142)
<223>  Conserved Sequence (CS), aka 5' cyclization sequence

<400>  75
aguuguuagu cuacguggac cgacaagaac aguuucgaau cggaagcuug cuuaacguag       60

uucuaacagu uuuuuauuag agagcagauc ucugaugaac aaccaacgga aaaagacggg      120

ucgaccgucu uucaauaugc ugaaacg                                          147


<210>  76
<211>  461
<212>  RNA
<213>  Dengue virus


<220>
<221>  promoter
<222>  (355)..(365)
<223>  Conserved Sequence (CS), aka 3' cyclization sequence

<400>  76
ccaacucauu cacaaaauaa aggaaaauaa aaaaucaaac aaggcaagaa gucaggccgg       60

auuaagccau agcacgguaa gagcuaugcu gccugugagc cccguccaag gacguaaaau      120

gaagucaggc cgaaagccac gguucgagca agccgugcug ccuguagcuc caucgugggg      180

auguaaaaac ccgggaggcu gcaaaccaug gaagcuguac gcauggggua gcagacuagu      240

gguuagagga gaccccuccc aagacacaac gcagcagcgg ggcccaacac caggggaagc      300

uguacccugg ugguaaggac uagagguuag aggagacccc ccgcacaaca acaaacagca      360

uauugacgcu gggagagacc agagauccug cugucucuac agcaucauuc caggcacaga      420

acgccaaaaa auggaauggu gcuguugaau caacagguuc u                          461


<210>  77
<211>  11
<212>  RNA
<213>  Dengue virus

<400>  77
ucaauaugcu g                                                            11


<210>  78
<211>  11
<212>  RNA
<213>  Dengue virus

<400>  78
cagcauauug a                                                            11


<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81
<211>  87
<212>  RNA
<213>  synthetic construct

<400>  81
guguuacacu uggcguucgc gaaggagagg agaggaagag gagagcgaac gccaucagua       60

aauuuauuua cugaaaaugu aacauuu                                           87


<210>  82
<211>  88
<212>  RNA
<213>  synthetic construct

<400>  82
gcugauggug uucuucgcgu cgaaggagag gagaggaaga ggagagacgc gaagacucgu       60

uacauuugua acgaguuucc gucagcuu                                          88


<210>  83
<211>  85
<212>  RNA
<213>  synthetic construct

<400>  83
acaguuuggu guccugcugc gaaggagagg agaggaagag gagagcagca ggacggccau       60

cauuuaugau ggccucgaac uguuu                                             85


<210>  84
<211>  88
<212>  RNA
<213>  synthetic construct

<400>  84
gaauuuuccu uuguucggcc cgaaggagag gagaggaaga ggagagggcc gaacaguugu       60

gguuuuaacc acaaccagga aaauucuu                                          88


<210>  85
<211>  84
<212>  RNA
<213>  synthetic construct

<400>  85
ugaucgucuu ccagaucucg aaggagagga gaggaagagg agagagaucu ggaagaacac       60

cuuuaggugu ucugggcgau cauu                                              84


<210>  86
<211>  449
<212>  RNA
<213>  synthetic construct


<220>
<221>  misc_RNA
<222>  (1)..(449)

<400>  86
guguuacacu uggcguucgc gaaggagagg agaggaagag gagagcgaac gccaucagua       60

aauuuauuua cugaaaaugu aacauuucuu uugcugaugg uguucuucgc gucgaaggag      120

aggagaggaa gaggagagac gcgaagacuc guuacauuug uaacgaguuu ccgucagcuu      180

uuacaguuug guguccugcu gcgaaggaga ggagaggaag aggagagcag caggacggcc      240

aucaucuuuu augauggccu cgaacuguuu uugaauuuuc cuuuguucgg cccgaaggag      300

aggagaggaa gaggagaggg ccgaacaguu gugguucuuu uaaccacaac caggaaaauu      360

cuuuuugauc gucuuccaga ucucgaagga gaggagagga agaggagaga gaucuggaag      420

aacaccuuua gguguucugg gcgaucauu                                        449


<210>  87
<211>  1052
<212>  RNA
<213>  synthetic construct


<220>
<221>  5'UTR
<222>  (1)..(94)

<220>
<221>  misc_RNA
<222>  (1)..(140)
<223>  5' leader

<220>
<221>  promoter
<222>  (132)..(140)
<223>  Engineered 5' cyclization motif

<220>
<221>  misc_RNA
<222>  (144)..(592)
<223>  Contains and example series of MV-RNA

<220>
<221>  3'UTR
<222>  (594)..(1052)

<220>
<221>  promoter
<222>  (949)..(957)
<223>  Engineered 3' cyclization motif

<400>  87
aguuguuagu cuacguggac cgacaagaac aguuucgaau cggaagcuug cuuaacguag       60

uucuaacagu uuuuuauuag agagcagauc ucugaugaac aaccaacgga aaaagacggg      120

ucgaccgucu uaauggucgc ugaguguuac acuuggcguu cgcgaaggag aggagaggaa      180

gaggagagcg aacgccauca guaaauuuau uuacugaaaa uguaacauuu cuuuugcuga      240

ugguguucuu cgcgucgaag gagaggagag gaagaggaga gacgcgaaga cucguuacau      300

uuguaacgag uuuccgucag cuuuuacagu uugguguccu gcugcgaagg agaggagagg      360

aagaggagag cagcaggacg gccaucaucu uuuaugaugg ccucgaacug uuuuugaauu      420

uuccuuuguu cggcccgaag gagaggagag gaagaggaga gggccgaaca guugugguuc      480

uuuuaaccac aaccaggaaa auucuuuuug aucgucuucc agaucucgaa ggagaggaga      540

ggaagaggag agagaucugg aagaacaccu uuagguguuc ugggcgauca uugccaacuc      600

auucacaaaa uaaaggaaaa uaaaaaauca aacaaggcaa gaagucaggc cggauuaagc      660

cauagcacgg uaagagcuau gcugccugug agccccgucc aaggacguaa aaugaaguca      720

ggccgaaagc cacgguucga gcaagccgug cugccuguag cuccaucgug gggauguaaa      780

aacccgggag gcugcaaacc auggaagcug uacgcauggg guagcagacu agugguuaga      840

ggagaccccu cccaagacac aacgcagcag cggggcccaa caccagggga agcuguaccc      900

uggugguaag gacuagaggu uagaggagac cccccgcaca acaacaaagc gaccauucgc      960

ugggagagac cagagauccu gcugucucua cagcaucauu ccaggcacag aacgccaaaa     1020

aauggaaugg ugcuguugaa ucaacagguu cu                                   1052


<210>  88
<211>  13202
<212>  RNA
<213>  Dicistrovirus DVVv3


<220>
<221>  5' UTR
<222>  (1)..(675)

<220>
<221>  CDS
<222>  (7420)..(9066)
<223>  ORF1 protein, RdRp

<220>
<221>  promoter
<222>  (9193)..(9234)
<223>  IGR intergenic region

<220>
<221>  CDS
<222>  (9235)..(12456)
<223>  ORF2, structural protein. Replaced with a Central Region of 
       tandem MV-RNA as in FIG. 1.

<220>
<221>  3' UTR
<222>  (12454)..(13202)

<400>  88
ccauuacggc cgggggaaaa uaagggcuau ggcgucaugc cauaguuuau auacaccacg       60

gauuacguga accuuguuag uaauaacggg ugcccuuugu uagggaugug uuuuaugaau      120

uauuaauuau guuauaacuc uuauuuucaa cuacgggauu aaaaccccac uuuaaaacua      180

uauagggaaa uuuaguuuaa accuguauag gaaauuaagg auugauaauu uuauugaacg      240

agccuacucg uugaauauuu auaguuaguu gugauaacua gccuuguauu uagacaugga      300

uaaucuccag cccauguucg acauaccuua ggaaguuuau augcggcacg uauucaauua      360

aaugaagaug cuauaagugc uugauuagac auuaaaacua gaacaaguuc ucuaguuguc      420

gcugguagag cauaacuuau aguaggugga uuuuauuuga ugacccaagu auuuaugaaa      480

uuugucggcc uccaaguuga ucagcuaauu auuuauauuu ugcgaguaau aguaguucag      540

acugugcuau ccccuugaca ugcauuuuuu gguuacucca gauugugaua uuagggcucu      600

aauauugcaa gacugcccac caaguaagga acuuauguaa acuugcuugg gaaacacauu      660

acucaaaaaa uuauuaugga aaguucaaau aagaauaugu guacuggauu cccccaaacc      720

cuuaaaaucu caacggaaau uaguaucaua aaccaaucau cucaaacccc cagagauugg      780

ucuuauguac aagaaaauau gcaacaguuu aaaaauuauu uacaauuagc auggauugaa      840

guuccgaaua acauuacaau aggaaauuuu gacguuuuug aagauaauau gccaauugcu      900

cacgcuauuu caucggauuu gcaucaaaca gcagguauug cugguguuuu aagacaaaau      960

uauuuuaaaa aucuaccuaa aguuaacgua aauaaaagua auauuggaac cuuauauuug     1020

uauccaaaua aaaauuuaac ucgacaaauu auuggauuga uuacuaaaga uauuuauuau     1080

uuaaaaccaa cuuaugcuuc acuuuuuaca acuuuaauug aauugcguaa auaucuuauu     1140

aauaauaaaa uaaaaaauau uugccuaccu augguagguu guaauaaaga uaaauuaaau     1200

ccucuugcag uuuuacccau gcuaauguau ugccucggca auauugaaac ucaaguaaaa     1260

auaacuaaua aaggaguuua uuuuaauuau caaccaauuc cuguugcucc aaaaauuaau     1320

aaaauuaaau uuaguaaaca aauggaaaaa guuaauuaug aucaaacugu agauacuuuu     1380

gaaacaaauu auguuaaacc uaagaaauuc aaagcuaaag uaacauuuga acccucucuu     1440

uuaaaucuug auucuaauag uauuauaauu aaugaaagua agacaguaaa acaaauuuau     1500

aaagcuaaau uagaaaaagu aauauaucaa agaucuacag uuuaugaacc acaaaagaag     1560

acauaugugg uagaagcuuu uucuuguaaa caaccuaaac caauugucaa aauuuuuaaa     1620

augaaacaag caauuuuaac ucaaacugac uuaaaagaaa auaauaauga acuaauuaaa     1680

gaaagaaaua guauugauua uuauaaauuu guuacaccua acaccguuaa agcuauuauc     1740

ggauacgaca aaguagaauc aguuuugaca uuugauuugg aucguaaacg uagaugugga     1800

gaaaaagcuu uuguacaugg aaaaucuuua aaaucaauag cuaaacgaca acuguguuau     1860

aguuauguac caucucuaaa cucagugcaa guauauauua aaauguuaca auuaacggcg     1920

cagaaacaag uauuugguca uguaguaacg aaaauucaag aaaguauugc caauauggau     1980

guucauggaa ugcaaauuaa caauauaccu gaagaauuaa ugaaaucauu auccagaaca     2040

auuuuagaac aauuacaauu agacacuaaa guaauaaaac caguuuuguu agcaaauaua     2100

uuaaauuguu ucguaaaugu uguuugugcc uuaauaauaa uauucacugc caaaaguaaa     2160

guugcaucug gagcagcuau uguucaaaua auuucaaaua uuuuaaccuu aauguuggau     2220

auaggcauuu auuauucacu uaaacauaug accgaagaaa gaauuaaagc aauaacuacg     2280

acuauaacac aggaugcugu ccaaaaagua augaaacaac auggcguaac uaugauggca     2340

ucugauaaag uaauaacagc caugcaaaau gucgauuuaa augaugcuaa aucaauaaag     2400

cauuuuauaa aagaauucga aaaagaagaa gauaccgaca uuucagaaau uucacccgau     2460

uguguaccaa acuauucuga uauguuaccu auuggauuac aaaugaaaaa gaagaacagg     2520

cuugauaugg auuuuguuuu gauggacaaa auagcaguug uugauccaac ggguaaguua     2580

augaagauag uuagugacug uccauacgac acaccuagua aaaauaauca guguuugcuc     2640

cacucccuuc ugggugcacu agaucauaga gauagaaaag uuuuagugga ugaaaguaau     2700

auugaaaaau ucuuccaaug gauguccgau aauauuagug auccagaugu gauugaagca     2760

auuaauguuu auaaaaugga guaugcuucu gauuucccac cagaagcaac uaauuuagau     2820

guuuuacaag gaauuaaaac ucauaagaaa auguuaccag uugaccuuug uaaauuacuc     2880

ucaaaauauu uggaccguac uauaauugua aaacauguaa auaaaguuuu gacuuaugga     2940

ccggaaagau gggauaacaa uauaccaaaa auacuccaau uagaaaauca acauuuuagc     3000

uauauugacc gaguacuagu ggauaauauu uugccauuaa aagcagcagu ugaguguaug     3060

guucaauuua cuuuaacacg agccgcacaa uuuaauacac ccgauacacu uaaacaaaaa     3120

gaguauuauu uagcgauggc agcagcauac guuuuuacau auaauucuag aauugcugug     3180

uguuguauga augugaaauc uaauaagcuu gaugcgaaau caauuauugg uauuugcaca     3240

gauauucugu cuacaauugc uuucguaguu gguaugggag uaucuagugg ugauuuugca     3300

ucacgcaugg uaaaggcuga gaaauuuuca acaucuaugg auacauuugc aucuaggaca     3360

acuaauaagu uagauucgau uuuaucgaaa gcuuucggua uuuauauguc ggaagauggc     3420

gaaacgguug caaguuuauc caaagauauu gauauacuag agaaauauaa agcacauacu     3480

guagccgauu auaugaauaa uaugucaaaa uaucaagaag uuaaaacaua uguagaagga     3540

guuacaaaac guaugacauc acuacaccua uuaaauagag auaccacuaa ugcuauucaa     3600

aauacgcaaa auauuauaag aaagaguugu gaugccauaa uggcaguuuu gaaugacguu     3660

gauaaguuga auagaaugga aucauugaga caggaauuug ugggccuuaa gggagcuggu     3720

aaaaccucaa cauugaacaa uuaucuaaua ccaaauauug cuaagcgcuu ggcguugaau     3780

ccaagcaccu augcagcaga aauugacgcg aauggacauu ggaaacccua uagauaugaa     3840

gauuuugcuu uaauagauga uuuguuuaau caggguagua acgaccccuu uauaccacau     3900

auuguaagga uggcuuccuc ucuuaacuuu gauuuaccug gagcugacuu gagcaauaaa     3960

gagaaaacuu uaagggcuag auucuuguuu gcgacagcaa acguugcaua uguaagaaug     4020

aaggaagaaa ugcccgcuag ugcucaggaa ggauuuuaug guagauuuaa guguauucaa     4080

uuuauuaaug ccaaacaagg uauuaaucag gcaagagauu caguggaaua caucgacuau     4140

gaagaucaug auacauauga auugagaaug uaugaagaac aaauuaauga acaauucuca     4200

cagauugaaa gaaaugacca uauaacuggu gaacguauac aacauuuuga uccuucuacu     4260

aagacuuaug augaccauau uuacaaaaua ggacauuuac auuauaaaau uguaaccuuu     4320

aaacaguuag aaacaauuug uauagaucag uuuaauaaaa aguaucaaca uuacaaaaug     4380

gcuagagauc guaaaugugu aguggacuuu gaauauuuua gaaauauuga uaugaaauca     4440

gacgcaauag uagaaaauau gguacguaag gguuaucucc cagcagaaau ugaagcagca     4500

agacaaacug uaggacuuac agcuggacca gaugaagugc augccaaauc ugaaucuaua     4560

auuaaucauu acguuguauc aguuuuuggc gauacuggaa cuggaaaauc uguuuuugcu     4620

acacagcugg cguuagaucu gucagacuuu cugaauuuga aaguauauuc uguggaagau     4680

auaaaugaua cggcccauuu agacuacuua aauccaagua uaauuguuuu ccaugauagc     4740

auuuaugaug aauugaaaua uguugcauua uaugauaaau uaccaaaacc auguuuaaua     4800

auaacuacaa guaaucauac auuaaaaugg cauagagaga aauuauguaa uauuguugau     4860

aauaguacuu cagcagcaga gcgcucuucu agugcuuugu uggaacaugg uuucuuuaac     4920

aaaaugaaaa auaaaauugg cggacuuguu ucuuauuuua auuugucaag uauuagagaa     4980

gguuauuugg uucaaacauu cccaggauac caaccaacac cugguuauug uagaagacua     5040

gguuugaaca cugcauucca cccgauaucg acagaagauu ugacaucuaa uuuaguauau     5100

ucacagcguc cuaauaaaga aacuacaacc auuuuugcaa cuucaggaua ccauuuccau     5160

caggauaaua aagaagugca auuaaacgaa gucguuaaag aaguuuuaau gaaauauaga     5220

ggagcuaaga aauucauuca gccugauauu aucaaauuag gaguaucaga auuugaggaa     5280

caauuuaaga aauuaacaac uauugaugua gaaauucagu cuaaaaauau ugagucauug     5340

auuaaauuaa cgaacgauag agcuauacua guaaacucug uaacugcagc uagauuuguu     5400

ggugguucua auauuguuaa aguuuccagu agagucagau caaauaauua uucuuuuaau     5460

ccucuagauu uugcuauucc uauuaaugcu acuguaucug augcacuaga uauagcaaug     5520

aaaucuuaua ggcuauuauu gagugcaaau guagauuaua caguauuuau caaaugugaa     5580

gaauuuucuu guauagguau uaacggcaau auuuacuaua cuucaguacc uuuuaaugua     5640

acuucuuauu cacauauugc aacuaaagua auaacauuuu auaaaguaga uacuaauuca     5700

gauggaauaa caaauaauuc agaauuaauc aaauuuacac cggaugaaua ugcuaaauua     5760

auuauuacag gagaaggaga acaaaaacuu uuugauaagu ugccuuaugc agcuuguaaa     5820

uauauuuaug gcgcuagagc agagauugaa ccacauuuug cgacaacauu uacuaaauac     5880

gaaguuagaa cagaaguuua ugauaaucau acuagagaga aaauggcuuu cuuuguaauu     5940

uauucagaau uuaagaaaac aauuugguau aaaauagcua uagguauuuu ggcuauaacu     6000

gcaucaguuu uaauaauuga auuaauaaca caaauuugga auauguuuau ugguuuaaaa     6060

gaaguuuuua caaguaccgu ucaaaaagau aauguuaaag uaguuuauca aguuuuauca     6120

guuaauccua aagagcaauc agcagaaguu aaaguuuaug guuuuaaaga ugauuuagau     6180

ucauucucua auaaagaguu auccaauuua auuauagaug auauugaugu ugcgaaauua     6240

gaugauucaa uccccgcaga uacuguaauu aaagccuugg auaugucgca aaugacugug     6300

cauagugauu ggaauaagaa agacuuugcu aaaaacaaag uaccuacauu gguccauaga     6360

auguuggaua ugcgcguuca uagcgauaaa ucccaggaua auaagaaaau uucuaggaag     6420

gcuaaccgug uggagagaau uuuagaaaau augacaguua aaggugaauu cgauuuuauu     6480

aaacauaaaa uuacaaacuc ucucggcaag guuguuguuu ccgcaagcgg uguaguuaag     6540

acggucguag guaugaacau uaaaggacau uauguaauuu guccagcaca uguuuaucca     6600

guugauacag cguuccauua ugcaaauuuu accccguuua auacggguaa aaauuacaca     6660

augguaccaa uggucuguag uagaguagau gauuuggcuu uguuuuacau aacugauaaa     6720

uuacauccau uagcgaaaga uauuacacau cauuuugaug aucaggaacg uuuauauacu     6780

cgaccauucg aguugccuua uaugcauuua cgaacuggua auguaguauc uuggaaaggu     6840

ggagaugcua uuggauugcg aucauugguu acaaaaguuc aucaagacau guuauuaaca     6900

gaaggaaaac cuaugguagc aggucaauuu uggaguacgg uuacucgccu uacuaaaggc     6960

gauuguggau ucccaauaau agauacuaac ucucauaaaa uauuuucuau uuauugugga     7020

gauaauaaug gcguuaaugc uauuuaugga aauaugguaa caucaacauu gguuaagaaa     7080

augauugacu uugcugaagg uguaucugaa guacacgcuu uuacucguua uaguccaccc     7140

auggaagagu ucuuugaugc agaagauacu gguguuauga aguuuuccua uccaucugga     7200

gaacaacaua uuguuaugcc uguugaaacu ugugauuaua ucucaaaagc auaugaaacu     7260

gaaaacuauu acccuugcau ggauggagaa uuuacgagga auaucgcgua caguagugau     7320

ugucaaaaga acgcauuuau gaaaccuaaa uaucaacgaa caccuuuugc ugaagaaauu     7380

uuaacucaau auccacaaau uaaagaugau uguagaaau gcc gcu acu gac cca        7434
                                           Ala Ala Thr Asp Pro            
                                           1               5              

agg uua gua gaa gau aaa uca aaa uua gua aau uca guu aaa gga gac       7482
Arg Leu Val Glu Asp Lys Ser Lys Leu Val Asn Ser Val Lys Gly Asp           
                10                  15                  20                

cca uca auu guu aug aca caa cug gca aag auu aau gac ccc aua gau       7530
Pro Ser Ile Val Met Thr Gln Leu Ala Lys Ile Asn Asp Pro Ile Asp           
            25                  30                  35                    

gca gcu ggu gga cuu aug ggu gag aag uuu aug gaa gaa gca gcu gaa       7578
Ala Ala Gly Gly Leu Met Gly Glu Lys Phe Met Glu Glu Ala Ala Glu           
        40                  45                  50                        

aug uua aca gaa gag uau auu gac uug uau agc ggu uuu gac cau aga       7626
Met Leu Thr Glu Glu Tyr Ile Asp Leu Tyr Ser Gly Phe Asp His Arg           
    55                  60                  65                            

uuu uug acu aca gaa gaa acg aua aau ggu auu gca agu ccu caa ucg       7674
Phe Leu Thr Thr Glu Glu Thr Ile Asn Gly Ile Ala Ser Pro Gln Ser           
70                  75                  80                  85            

gau uua caa ggu cau uua gaa gcu gua aau aga gau gcg ucu gca ggu       7722
Asp Leu Gln Gly His Leu Glu Ala Val Asn Arg Asp Ala Ser Ala Gly           
                90                  95                  100               

cau ugg ugu aug cua aau gga uau cau aaa auu ucu gau uua uua gaa       7770
His Trp Cys Met Leu Asn Gly Tyr His Lys Ile Ser Asp Leu Leu Glu           
            105                 110                 115                   

gaa ggu ggu agu uac ccu uca ggu caa cua cgg uau cau uuu aag aaa       7818
Glu Gly Gly Ser Tyr Pro Ser Gly Gln Leu Arg Tyr His Phe Lys Lys           
        120                 125                 130                       

gag aau aaa gua auu gcu aaa uua gaa aaa cau aua uca caa caa aag       7866
Glu Asn Lys Val Ile Ala Lys Leu Glu Lys His Ile Ser Gln Gln Lys           
    135                 140                 145                           

aag aug ugg gca aaa ggu auu cgu uac gaa ggu uua acu aaa gau aau       7914
Lys Met Trp Ala Lys Gly Ile Arg Tyr Glu Gly Leu Thr Lys Asp Asn           
150                 155                 160                 165           

uua aaa gcc gaa uua aga cca uuu gaa aaa gug aga auu gga aaa acg       7962
Leu Lys Ala Glu Leu Arg Pro Phe Glu Lys Val Arg Ile Gly Lys Thr           
                170                 175                 180               

cgu gua uuu gaa agu uuu gac uuc uuu aca acc uuu aac cau aga caa       8010
Arg Val Phe Glu Ser Phe Asp Phe Phe Thr Thr Phe Asn His Arg Gln           
            185                 190                 195                   

cua uuu gga acg aua caa gcu gca aug aag aag cag aga gcu cgg gga       8058
Leu Phe Gly Thr Ile Gln Ala Ala Met Lys Lys Gln Arg Ala Arg Gly           
        200                 205                 210                       

aca ugu caa auu gga uua gcu caa uau gau uuu acg cac uug uau aau       8106
Thr Cys Gln Ile Gly Leu Ala Gln Tyr Asp Phe Thr His Leu Tyr Asn           
    215                 220                 225                           

aga uug cug cag acc ucu cca uuu gcu guu cac ggg gac uuc gag gcc       8154
Arg Leu Leu Gln Thr Ser Pro Phe Ala Val His Gly Asp Phe Glu Ala           
230                 235                 240                 245           

ugg gau aag cau aug gau ugg uuu uca gua cag uug gcu ugu aag aug       8202
Trp Asp Lys His Met Asp Trp Phe Ser Val Gln Leu Ala Cys Lys Met           
                250                 255                 260               

ugg acg aag guu uua ugg aaa uca cca caa uuc caa cau ugg aau gau       8250
Trp Thr Lys Val Leu Trp Lys Ser Pro Gln Phe Gln His Trp Asn Asp           
            265                 270                 275                   

aaa aua aau gca cac aaa uuu gaa ugu gaa gaa aau uua uac cug aug       8298
Lys Ile Asn Ala His Lys Phe Glu Cys Glu Glu Asn Leu Tyr Leu Met           
        280                 285                 290                       

uug gaa acu gca aug uuu ucu aau gug uau gcu guu acu uug gca gau       8346
Leu Glu Thr Ala Met Phe Ser Asn Val Tyr Ala Val Thr Leu Ala Asp           
    295                 300                 305                           

gga cau aua aua guu aaa gaa aga ucu caa ugu uca gga gua gua gaa       8394
Gly His Ile Ile Val Lys Glu Arg Ser Gln Cys Ser Gly Val Val Glu           
310                 315                 320                 325           

acg aca acu uua aau ucu acu guu aau gac auu aag ugu gug gcu guu       8442
Thr Thr Thr Leu Asn Ser Thr Val Asn Asp Ile Lys Cys Val Ala Val           
                330                 335                 340               

aua uug uau cug aua aag aaa cau aac gug gug cuu aga acu cua ggu       8490
Ile Leu Tyr Leu Ile Lys Lys His Asn Val Val Leu Arg Thr Leu Gly           
            345                 350                 355                   

gcu ucg gaa gca gau gca agg aag uac uau gaa gau uac uug gaa aca       8538
Ala Ser Glu Ala Asp Ala Arg Lys Tyr Tyr Glu Asp Tyr Leu Glu Thr           
        360                 365                 370                       

uug gag cuu uca aag aag agu aga aaa gcu uua uua aca ucg aaa cau       8586
Leu Glu Leu Ser Lys Lys Ser Arg Lys Ala Leu Leu Thr Ser Lys His           
    375                 380                 385                           

auu uau uca ccg auu aua cca gau aga aga acg auu aaa caa aac uuu       8634
Ile Tyr Ser Pro Ile Ile Pro Asp Arg Arg Thr Ile Lys Gln Asn Phe           
390                 395                 400                 405           

gau aug aua uau uau ggc gau gau auu ggu auu gua gua aau uua gaa       8682
Asp Met Ile Tyr Tyr Gly Asp Asp Ile Gly Ile Val Val Asn Leu Glu           
                410                 415                 420               

uuu cug uuu auu gua aau uuu guu uca auu aaa aau gcu uau aaa uac       8730
Phe Leu Phe Ile Val Asn Phe Val Ser Ile Lys Asn Ala Tyr Lys Tyr           
            425                 430                 435                   

uug uuc ggu auu aau uug gac uca ccu cau aaa gau ggg uca uua gua       8778
Leu Phe Gly Ile Asn Leu Asp Ser Pro His Lys Asp Gly Ser Leu Val           
        440                 445                 450                       

ccu uuu gug ccu uua aau gaa uug gaa uuu guu agu aga acu uuu gau       8826
Pro Phe Val Pro Leu Asn Glu Leu Glu Phe Val Ser Arg Thr Phe Asp           
    455                 460                 465                           

uau cau ucu gau acu aga acc guu uau ccu aaa uua aaa gaa caa uca       8874
Tyr His Ser Asp Thr Arg Thr Val Tyr Pro Lys Leu Lys Glu Gln Ser           
470                 475                 480                 485           

auu ugg aga cuu uug uuc ugg ugu acu aau uua cgu cca gag cag aua       8922
Ile Trp Arg Leu Leu Phe Trp Cys Thr Asn Leu Arg Pro Glu Gln Ile           
                490                 495                 500               

gaa ucc aau aug auu gca aug gcu aac gaa uug uuc cuu uau gaa gaa       8970
Glu Ser Asn Met Ile Ala Met Ala Asn Glu Leu Phe Leu Tyr Glu Glu           
            505                 510                 515                   

agu aaa uac aga uug uuu agu uca auu guc aac gca aua aua uca cca       9018
Ser Lys Tyr Arg Leu Phe Ser Ser Ile Val Asn Ala Ile Ile Ser Pro           
        520                 525                 530                       

uau cug aaa cgc caa uau aau ugg aau uug aua uua cca agu uau aga       9066
Tyr Leu Lys Arg Gln Tyr Asn Trp Asn Leu Ile Leu Pro Ser Tyr Arg           
    535                 540                 545                           

cuuggaaggg uagcauuuga ggagaugucg caugaacuga aggaggugcc ucacucgagc     9126

accuguuuua cugaauugga gauucauuca auuuuacaga aagcgcaaaa uauaggaagc     9186

aacugacuaa ggacacuucc ucuuuuguaa uccguaaaga ucgaacaa aug auu aua      9243
                                                     Met Ile Ile          
                                                     550                  

aug gcg uca cca aaa acu uua caa aaa aug uuu aac acc uuu aua gug       9291
Met Ala Ser Pro Lys Thr Leu Gln Lys Met Phe Asn Thr Phe Ile Val           
        555                 560                 565                       

cgg aau ggg uua cca cua gaa uua ucu ggu acc ccu gcu uuc uua acc       9339
Arg Asn Gly Leu Pro Leu Glu Leu Ser Gly Thr Pro Ala Phe Leu Thr           
    570                 575                 580                           

gca gau gag cag aau gua gac ucc auu ugg agu guu uca uuc aaa ccg       9387
Ala Asp Glu Gln Asn Val Asp Ser Ile Trp Ser Val Ser Phe Lys Pro           
585                 590                 595                 600           

cuu auu gaa gcg ccu cuu gcu gug uac aag guu guc cuc cag aga gcu       9435
Leu Ile Glu Ala Pro Leu Ala Val Tyr Lys Val Val Leu Gln Arg Ala           
                605                 610                 615               

ugc uca aag gag gaa aac auu gua uac aaa aag gca uau agu guu ucu       9483
Cys Ser Lys Glu Glu Asn Ile Val Tyr Lys Lys Ala Tyr Ser Val Ser           
            620                 625                 630                   

gua agc auu gau uca aac acu ugg auu gac aga aua caa cug caa ugu       9531
Val Ser Ile Asp Ser Asn Thr Trp Ile Asp Arg Ile Gln Leu Gln Cys           
        635                 640                 645                       

guu uug ccc ggc aua gaa cca ccu gug ucg agu aau caa aua aua caa       9579
Val Leu Pro Gly Ile Glu Pro Pro Val Ser Ser Asn Gln Ile Ile Gln           
    650                 655                 660                           

aaa caa caa aua gau uua uca cag ugg agu ggc auu uuc caa gag gga       9627
Lys Gln Gln Ile Asp Leu Ser Gln Trp Ser Gly Ile Phe Gln Glu Gly           
665                 670                 675                 680           

cuu uca aau uug gaa guc cau ucu aaa gcu gug aca aca aag aca ucc       9675
Leu Ser Asn Leu Glu Val His Ser Lys Ala Val Thr Thr Lys Thr Ser           
                685                 690                 695               

gcu gca acc uca uuu aau aua aua uca aau cca acg gag cau ggu aca       9723
Ala Ala Thr Ser Phe Asn Ile Ile Ser Asn Pro Thr Glu His Gly Thr           
            700                 705                 710                   

cca aua ccc auu acu ggu agu gac gca cca ggc gua ccu uug gau uua       9771
Pro Ile Pro Ile Thr Gly Ser Asp Ala Pro Gly Val Pro Leu Asp Leu           
        715                 720                 725                       

uua ucu ggu aug guc uau gca cag aaa aac cca acu auu uau gcu cau       9819
Leu Ser Gly Met Val Tyr Ala Gln Lys Asn Pro Thr Ile Tyr Ala His           
    730                 735                 740                           

gaa cca caa aua gua uau aga ggu acc auc uca ucu aaa gcc gcu aga       9867
Glu Pro Gln Ile Val Tyr Arg Gly Thr Ile Ser Ser Lys Ala Ala Arg           
745                 750                 755                 760           

ggu gau guu uua uua gac uug gau cug ggu aaa uua auu aac cag aau       9915
Gly Asp Val Leu Leu Asp Leu Asp Leu Gly Lys Leu Ile Asn Gln Asn           
                765                 770                 775               

aug gug ucu gca acu aag gau ugu uca aca uuc aag ggu ucu aua auu       9963
Met Val Ser Ala Thr Lys Asp Cys Ser Thr Phe Lys Gly Ser Ile Ile           
            780                 785                 790                   

gga acu guu gaa aug uug gcu aau cca gug guu gca ggu gca auu aug      10011
Gly Thr Val Glu Met Leu Ala Asn Pro Val Val Ala Gly Ala Ile Met           
        795                 800                 805                       

guu ggu uau gua ccg ccu gga aca acu aau aua aca gaa gaa guu aug      10059
Val Gly Tyr Val Pro Pro Gly Thr Thr Asn Ile Thr Glu Glu Val Met           
    810                 815                 820                           

aug ggu acu gaa ugu ggc guu guu agu gcu acg gac agu caa uuu uuc      10107
Met Gly Thr Glu Cys Gly Val Val Ser Ala Thr Asp Ser Gln Phe Phe           
825                 830                 835                 840           

ucu uuu gua uua aaa cca uau auu aaa agu acu ggu uca cca caa ggu      10155
Ser Phe Val Leu Lys Pro Tyr Ile Lys Ser Thr Gly Ser Pro Gln Gly           
                845                 850                 855               

aga uau gga ugg cua aau uuu gau acu aca aca gga gaa uau acg cuc      10203
Arg Tyr Gly Trp Leu Asn Phe Asp Thr Thr Thr Gly Glu Tyr Thr Leu           
            860                 865                 870                   

cca aag acg aca aag gau gcu uau cca cau uua gug auc aua gca aga      10251
Pro Lys Thr Thr Lys Asp Ala Tyr Pro His Leu Val Ile Ile Ala Arg           
        875                 880                 885                       

aau gcg uuu guu gcc uuu aau acg gca aca gaa gca gua guu aau guc      10299
Asn Ala Phe Val Ala Phe Asn Thr Ala Thr Glu Ala Val Val Asn Val           
    890                 895                 900                           

acu gua aug ucu ucu uuu gga ccg gau uuc uuc gca uuu uca gaa gga      10347
Thr Val Met Ser Ser Phe Gly Pro Asp Phe Phe Ala Phe Ser Glu Gly           
905                 910                 915                 920           

cca gaa aua aca gga cug aaa uua aca gau agu gca ugg guc gca cca      10395
Pro Glu Ile Thr Gly Leu Lys Leu Thr Asp Ser Ala Trp Val Ala Pro           
                925                 930                 935               

aaa agu gau guc uuu gga gca ucu aga uca gua uua acc agu uau ggu      10443
Lys Ser Asp Val Phe Gly Ala Ser Arg Ser Val Leu Thr Ser Tyr Gly           
            940                 945                 950                   

uug gaa cca aau gca gua auu gcu auu gau ggc agg gca acg cca aaa      10491
Leu Glu Pro Asn Ala Val Ile Ala Ile Asp Gly Arg Ala Thr Pro Lys           
        955                 960                 965                       

gaa aga auu guc uau cca uca gug auc uug cac uuu gca agc ugu gac      10539
Glu Arg Ile Val Tyr Pro Ser Val Ile Leu His Phe Ala Ser Cys Asp           
    970                 975                 980                           

acg uuc aau gaa gga gcg acg auu aag aau guu ggu aug ugg aca uau      10587
Thr Phe Asn Glu Gly Ala Thr Ile Lys Asn Val Gly Met Trp Thr Tyr           
985                 990                 995                 1000          

gga gca aau acu gua  guu ggu ucu cca gga  gug aga agc uau gga        10632
Gly Ala Asn Thr Val  Val Gly Ser Pro Gly  Val Arg Ser Tyr Gly             
                1005                 1010                 1015            

aca ugu uuu cuu gaa  auu aca acu aga gag  gau acu ggg aau gaa        10677
Thr Cys Phe Leu Glu  Ile Thr Thr Arg Glu  Asp Thr Gly Asn Glu             
                1020                 1025                 1030            

aca ucu uug acu aug  caa cua cac uug ggc  aca gca aca gau ccu        10722
Thr Ser Leu Thr Met  Gln Leu His Leu Gly  Thr Ala Thr Asp Pro             
                1035                 1040                 1045            

uau aau uca uuu ggc  gaa gcu aau acu caa  uau aug caa gcu gaa        10767
Tyr Asn Ser Phe Gly  Glu Ala Asn Thr Gln  Tyr Met Gln Ala Glu             
                1050                 1055                 1060            

aga uau uau gga gau  uuu aaa gca aga gcu  guu ggu guu guc gag        10812
Arg Tyr Tyr Gly Asp  Phe Lys Ala Arg Ala  Val Gly Val Val Glu             
                1065                 1070                 1075            

gug uau uug acg gcc  acu gau aua gaa ccu  ucu cuu aaa uca uau        10857
Val Tyr Leu Thr Ala  Thr Asp Ile Glu Pro  Ser Leu Lys Ser Tyr             
                1080                 1085                 1090            

gaa uuu gau guu gag  cuu gau uca auu aga  aaa gca acu gua aca        10902
Glu Phe Asp Val Glu  Leu Asp Ser Ile Arg  Lys Ala Thr Val Thr             
                1095                 1100                 1105            

aga cau guu ggu aau  uua ucu ucu gau ggg  aca auu aau aau uau        10947
Arg His Val Gly Asn  Leu Ser Ser Asp Gly  Thr Ile Asn Asn Tyr             
                1110                 1115                 1120            

uau aug gua uuu gau  aac uau gaa uca gua  gug aaa guu uug gac        10992
Tyr Met Val Phe Asp  Asn Tyr Glu Ser Val  Val Lys Val Leu Asp             
                1125                 1130                 1135            

auu ccu uua cca ggc  uuu aaa agu aug aca  uac guu gug aag agu        11037
Ile Pro Leu Pro Gly  Phe Lys Ser Met Thr  Tyr Val Val Lys Ser             
                1140                 1145                 1150            

uau gca guc aau gua  aca uuc gau uuu uca  ucu aca uca cuu auu        11082
Tyr Ala Val Asn Val  Thr Phe Asp Phe Ser  Ser Thr Ser Leu Ile             
                1155                 1160                 1165            

aga gga auc acu aau  caa gau auc acc auu  uua ccu gga aau agu        11127
Arg Gly Ile Thr Asn  Gln Asp Ile Thr Ile  Leu Pro Gly Asn Ser             
                1170                 1175                 1180            

ugc gau guu ugu gug  aua gaa ccu aag gau  ggu guu cug ccu aau        11172
Cys Asp Val Cys Val  Ile Glu Pro Lys Asp  Gly Val Leu Pro Asn             
                1185                 1190                 1195            

auu ccg cag acu ggc  auc cuu acg gau aau  uau aau acu gga ccu        11217
Ile Pro Gln Thr Gly  Ile Leu Thr Asp Asn  Tyr Asn Thr Gly Pro             
                1200                 1205                 1210            

uca uug uua gau ugc  cca agu cuu uau cau  uau uug uau ccu gca        11262
Ser Leu Leu Asp Cys  Pro Ser Leu Tyr His  Tyr Leu Tyr Pro Ala             
                1215                 1220                 1225            

uuu aau gag aau uua  guu aga uuu gac uug  guu gaa cuu gua acg        11307
Phe Asn Glu Asn Leu  Val Arg Phe Asp Leu  Val Glu Leu Val Thr             
                1230                 1235                 1240            

aau aca guc aug gca  acu aug guu uau cau  ccu aaa auu aaa acc        11352
Asn Thr Val Met Ala  Thr Met Val Tyr His  Pro Lys Ile Lys Thr             
                1245                 1250                 1255            

gua uuc aca acu cau  aga acg gcu gga agu  aau gau uca caa ugc        11397
Val Phe Thr Thr His  Arg Thr Ala Gly Ser  Asn Asp Ser Gln Cys             
                1260                 1265                 1270            

uau aug guc uca cga  uac uyu gca gga caa  aug gyu cug ucu aau        11442
Tyr Met Val Ser Arg  Tyr Xaa Ala Gly Gln  Met Xaa Leu Ser Asn             
                1275                 1280                 1285            

guu cag uug cuc gug  gau aau ggu aac uau  ccc agc acg caa gac        11487
Val Gln Leu Leu Val  Asp Asn Gly Asn Tyr  Pro Ser Thr Gln Asp             
                1290                 1295                 1300            

guu guu ggu uuc guu  acc agg cuc uug ggc  gau ucu aca gca uug        11532
Val Val Gly Phe Val  Thr Arg Leu Leu Gly  Asp Ser Thr Ala Leu             
                1305                 1310                 1315            

guu aga ggc auu gaa  agu aug aau guu cac  ggu aau gcu gaa gcu        11577
Val Arg Gly Ile Glu  Ser Met Asn Val His  Gly Asn Ala Glu Ala             
                1320                 1325                 1330            

cuu uug ggc gcc agc  acu gcc guu aau gcu  cua caa ccu cuu gca        11622
Leu Leu Gly Ala Ser  Thr Ala Val Asn Ala  Leu Gln Pro Leu Ala             
                1335                 1340                 1345            

aau uau uau cag aac  aaa gcg aau caa gau  ugg uau ugg aaa caa        11667
Asn Tyr Tyr Gln Asn  Lys Ala Asn Gln Asp  Trp Tyr Trp Lys Gln             
                1350                 1355                 1360            

aag caa gca gaa uau  gaa caa gaa caa gcc  cuu uug gca gca aaa        11712
Lys Gln Ala Glu Tyr  Glu Gln Glu Gln Ala  Leu Leu Ala Ala Lys             
                1365                 1370                 1375            

aau aaa aac gcu uua  gau auu gca aau guu  caa gcu caa aau caa        11757
Asn Lys Asn Ala Leu  Asp Ile Ala Asn Val  Gln Ala Gln Asn Gln             
                1380                 1385                 1390            

cuu gac uua caa aga  gcc aaa cuu gac ucc  caa uac ggg uug gca        11802
Leu Asp Leu Gln Arg  Ala Lys Leu Asp Ser  Gln Tyr Gly Leu Ala             
                1395                 1400                 1405            

ccc agc aau ggu gug  ucg acu agu guc aau  ucu uca ucg aca guu        11847
Pro Ser Asn Gly Val  Ser Thr Ser Val Asn  Ser Ser Ser Thr Val             
                1410                 1415                 1420            

ccu uau gua uau cau  ucg aca cuu ggu agu  aau guu cca ucc aau        11892
Pro Tyr Val Tyr His  Ser Thr Leu Gly Ser  Asn Val Pro Ser Asn             
                1425                 1430                 1435            

ccu agu gac ucu gau  gag aau gau guu ucu  cgu cga gcc auu agu        11937
Pro Ser Asp Ser Asp  Glu Asn Asp Val Ser  Arg Arg Ala Ile Ser             
                1440                 1445                 1450            

aug cgu gau ggu aag  aua aac aua agu gaa  ggc aau aga gua caa        11982
Met Arg Asp Gly Lys  Ile Asn Ile Ser Glu  Gly Asn Arg Val Gln             
                1455                 1460                 1465            

ccu ggu cca ucu aca  aca ucc agu guu uca  acc ucu gau gag aau        12027
Pro Gly Pro Ser Thr  Thr Ser Ser Val Ser  Thr Ser Asp Glu Asn             
                1470                 1475                 1480            

acg gga ggu aga gua  auu uac ccg acu ucg  acg aac ccu gau uug        12072
Thr Gly Gly Arg Val  Ile Tyr Pro Thr Ser  Thr Asn Pro Asp Leu             
                1485                 1490                 1495            

aca aca aug aua cag  cag acu gca aau aag  guu aaa gga ggg aau        12117
Thr Thr Met Ile Gln  Gln Thr Ala Asn Lys  Val Lys Gly Gly Asn             
                1500                 1505                 1510            

guu gau gca aau gga  gac cuu gug ccu uca  ggc aau cug gcu uca        12162
Val Asp Ala Asn Gly  Asp Leu Val Pro Ser  Gly Asn Leu Ala Ser             
                1515                 1520                 1525            

uua uug aaa gag gau  gaa uac aga aug ccc  aau uug gau gca cag        12207
Leu Leu Lys Glu Asp  Glu Tyr Arg Met Pro  Asn Leu Asp Ala Gln             
                1530                 1535                 1540            

gac cuc auu gau gcu  aaa gcu gac ccu gca  caa aau uug gcu uuu        12252
Asp Leu Ile Asp Ala  Lys Ala Asp Pro Ala  Gln Asn Leu Ala Phe             
                1545                 1550                 1555            

cag agu gau uac ucu  uau uac aau ucu ccu  gau acu uca aca gau        12297
Gln Ser Asp Tyr Ser  Tyr Tyr Asn Ser Pro  Asp Thr Ser Thr Asp             
                1560                 1565                 1570            

ggu cuu ggc gua aca  cca caa gga ccu cau  uau caa gua gag gau        12342
Gly Leu Gly Val Thr  Pro Gln Gly Pro His  Tyr Gln Val Glu Asp             
                1575                 1580                 1585            

cca caa gaa aac ccg  ccg cca guu cca aaa  aca ugg aug gag aag        12387
Pro Gln Glu Asn Pro  Pro Pro Val Pro Lys  Thr Trp Met Glu Lys             
                1590                 1595                 1600            

ugg aau uug agu aaa  cac gcu aaa uca agu  ggu uua cag ucu gcu        12432
Trp Asn Leu Ser Lys  His Ala Lys Ser Ser  Gly Leu Gln Ser Ala             
                1605                 1610                 1615            

gua caa aaa uua caa  ccc aaa uag gguaaccuau uuggggaccu cacuuuuagu    12486
Val Gln Lys Leu Gln  Pro Lys                                              
                1620                                                      

ugcuagcuaa caaugggggc cuuaaaauua ucuuauuacc uuaauugguu guaagugcug    12546

aauuuuaagg gggccgcgca uauugcguag uaagaccugg gccuugcaug uagcauuaua    12606

agucccacuc guuauagcuu aaaucguacc uuagcccgua cgagacaaga agugaauuau    12666

auuuaaccac cauauauuaa ucauuuagua uauaagguag auauuagaaa uuaaauaaua    12726

uagaaaugau gaauaaccua ucagcuuggu aauugccuaa augcgucugu uuucuguguc    12786

aauuuuagcg uaagcuggcc uugacacuuu uaaccggugc augaauagau uauuuuuaaa    12846

auuuguauuu uuacguaagu uugccuacaa aauuuuacau uucgaaacaa ucaugaauag    12906

aauaacagua aaagugcguu agucacgugg cgcaccuaua uuaacuuuuu uaacguuuau    12966

uucauuagua uagguuauuc auuauaauau auuguacaua uacuauaauu cccaaauuua    13026

uguuuguuau uguacacccc cgauuagucg guuuauauuu auauauuugg cucugcgaau    13086

gcaguuaaac gcuaccacuu uucggggacu aucuaaucuu uauauaaaau uaguuagucg    13146

gauuuuaggg ccuucagccc ucuaaucuuu uuauugaaaa aaaaaaaaaa aaaaaa        13202


<210>  89
<211>  549
<212>  PRT
<213>  Dicistrovirus DVVv3

<400>  89

Ala Ala Thr Asp Pro Arg Leu Val Glu Asp Lys Ser Lys Leu Val Asn 
1               5                   10                  15      


Ser Val Lys Gly Asp Pro Ser Ile Val Met Thr Gln Leu Ala Lys Ile 
            20                  25                  30          


Asn Asp Pro Ile Asp Ala Ala Gly Gly Leu Met Gly Glu Lys Phe Met 
        35                  40                  45              


Glu Glu Ala Ala Glu Met Leu Thr Glu Glu Tyr Ile Asp Leu Tyr Ser 
    50                  55                  60                  


Gly Phe Asp His Arg Phe Leu Thr Thr Glu Glu Thr Ile Asn Gly Ile 
65                  70                  75                  80  


Ala Ser Pro Gln Ser Asp Leu Gln Gly His Leu Glu Ala Val Asn Arg 
                85                  90                  95      


Asp Ala Ser Ala Gly His Trp Cys Met Leu Asn Gly Tyr His Lys Ile 
            100                 105                 110         


Ser Asp Leu Leu Glu Glu Gly Gly Ser Tyr Pro Ser Gly Gln Leu Arg 
        115                 120                 125             


Tyr His Phe Lys Lys Glu Asn Lys Val Ile Ala Lys Leu Glu Lys His 
    130                 135                 140                 


Ile Ser Gln Gln Lys Lys Met Trp Ala Lys Gly Ile Arg Tyr Glu Gly 
145                 150                 155                 160 


Leu Thr Lys Asp Asn Leu Lys Ala Glu Leu Arg Pro Phe Glu Lys Val 
                165                 170                 175     


Arg Ile Gly Lys Thr Arg Val Phe Glu Ser Phe Asp Phe Phe Thr Thr 
            180                 185                 190         


Phe Asn His Arg Gln Leu Phe Gly Thr Ile Gln Ala Ala Met Lys Lys 
        195                 200                 205             


Gln Arg Ala Arg Gly Thr Cys Gln Ile Gly Leu Ala Gln Tyr Asp Phe 
    210                 215                 220                 


Thr His Leu Tyr Asn Arg Leu Leu Gln Thr Ser Pro Phe Ala Val His 
225                 230                 235                 240 


Gly Asp Phe Glu Ala Trp Asp Lys His Met Asp Trp Phe Ser Val Gln 
                245                 250                 255     


Leu Ala Cys Lys Met Trp Thr Lys Val Leu Trp Lys Ser Pro Gln Phe 
            260                 265                 270         


Gln His Trp Asn Asp Lys Ile Asn Ala His Lys Phe Glu Cys Glu Glu 
        275                 280                 285             


Asn Leu Tyr Leu Met Leu Glu Thr Ala Met Phe Ser Asn Val Tyr Ala 
    290                 295                 300                 


Val Thr Leu Ala Asp Gly His Ile Ile Val Lys Glu Arg Ser Gln Cys 
305                 310                 315                 320 


Ser Gly Val Val Glu Thr Thr Thr Leu Asn Ser Thr Val Asn Asp Ile 
                325                 330                 335     


Lys Cys Val Ala Val Ile Leu Tyr Leu Ile Lys Lys His Asn Val Val 
            340                 345                 350         


Leu Arg Thr Leu Gly Ala Ser Glu Ala Asp Ala Arg Lys Tyr Tyr Glu 
        355                 360                 365             


Asp Tyr Leu Glu Thr Leu Glu Leu Ser Lys Lys Ser Arg Lys Ala Leu 
    370                 375                 380                 


Leu Thr Ser Lys His Ile Tyr Ser Pro Ile Ile Pro Asp Arg Arg Thr 
385                 390                 395                 400 


Ile Lys Gln Asn Phe Asp Met Ile Tyr Tyr Gly Asp Asp Ile Gly Ile 
                405                 410                 415     


Val Val Asn Leu Glu Phe Leu Phe Ile Val Asn Phe Val Ser Ile Lys 
            420                 425                 430         


Asn Ala Tyr Lys Tyr Leu Phe Gly Ile Asn Leu Asp Ser Pro His Lys 
        435                 440                 445             


Asp Gly Ser Leu Val Pro Phe Val Pro Leu Asn Glu Leu Glu Phe Val 
    450                 455                 460                 


Ser Arg Thr Phe Asp Tyr His Ser Asp Thr Arg Thr Val Tyr Pro Lys 
465                 470                 475                 480 


Leu Lys Glu Gln Ser Ile Trp Arg Leu Leu Phe Trp Cys Thr Asn Leu 
                485                 490                 495     


Arg Pro Glu Gln Ile Glu Ser Asn Met Ile Ala Met Ala Asn Glu Leu 
            500                 505                 510         


Phe Leu Tyr Glu Glu Ser Lys Tyr Arg Leu Phe Ser Ser Ile Val Asn 
        515                 520                 525             


Ala Ile Ile Ser Pro Tyr Leu Lys Arg Gln Tyr Asn Trp Asn Leu Ile 
    530                 535                 540                 


Leu Pro Ser Tyr Arg 
545                 


<210>  90
<211>  1073
<212>  PRT
<213>  Dicistrovirus DVVv3

<220>
<221>  misc_feature
<222>  (728)..(728)
<223>  The 'Xaa' at location 728 stands for Ser, or Phe.

<220>
<221>  misc_feature
<222>  (733)..(733)
<223>  The 'Xaa' at location 733 stands for Ala, or Val.

<400>  90

Met Ile Ile Met Ala Ser Pro Lys Thr Leu Gln Lys Met Phe Asn Thr 
1               5                   10                  15      


Phe Ile Val Arg Asn Gly Leu Pro Leu Glu Leu Ser Gly Thr Pro Ala 
            20                  25                  30          


Phe Leu Thr Ala Asp Glu Gln Asn Val Asp Ser Ile Trp Ser Val Ser 
        35                  40                  45              


Phe Lys Pro Leu Ile Glu Ala Pro Leu Ala Val Tyr Lys Val Val Leu 
    50                  55                  60                  


Gln Arg Ala Cys Ser Lys Glu Glu Asn Ile Val Tyr Lys Lys Ala Tyr 
65                  70                  75                  80  


Ser Val Ser Val Ser Ile Asp Ser Asn Thr Trp Ile Asp Arg Ile Gln 
                85                  90                  95      


Leu Gln Cys Val Leu Pro Gly Ile Glu Pro Pro Val Ser Ser Asn Gln 
            100                 105                 110         


Ile Ile Gln Lys Gln Gln Ile Asp Leu Ser Gln Trp Ser Gly Ile Phe 
        115                 120                 125             


Gln Glu Gly Leu Ser Asn Leu Glu Val His Ser Lys Ala Val Thr Thr 
    130                 135                 140                 


Lys Thr Ser Ala Ala Thr Ser Phe Asn Ile Ile Ser Asn Pro Thr Glu 
145                 150                 155                 160 


His Gly Thr Pro Ile Pro Ile Thr Gly Ser Asp Ala Pro Gly Val Pro 
                165                 170                 175     


Leu Asp Leu Leu Ser Gly Met Val Tyr Ala Gln Lys Asn Pro Thr Ile 
            180                 185                 190         


Tyr Ala His Glu Pro Gln Ile Val Tyr Arg Gly Thr Ile Ser Ser Lys 
        195                 200                 205             


Ala Ala Arg Gly Asp Val Leu Leu Asp Leu Asp Leu Gly Lys Leu Ile 
    210                 215                 220                 


Asn Gln Asn Met Val Ser Ala Thr Lys Asp Cys Ser Thr Phe Lys Gly 
225                 230                 235                 240 


Ser Ile Ile Gly Thr Val Glu Met Leu Ala Asn Pro Val Val Ala Gly 
                245                 250                 255     


Ala Ile Met Val Gly Tyr Val Pro Pro Gly Thr Thr Asn Ile Thr Glu 
            260                 265                 270         


Glu Val Met Met Gly Thr Glu Cys Gly Val Val Ser Ala Thr Asp Ser 
        275                 280                 285             


Gln Phe Phe Ser Phe Val Leu Lys Pro Tyr Ile Lys Ser Thr Gly Ser 
    290                 295                 300                 


Pro Gln Gly Arg Tyr Gly Trp Leu Asn Phe Asp Thr Thr Thr Gly Glu 
305                 310                 315                 320 


Tyr Thr Leu Pro Lys Thr Thr Lys Asp Ala Tyr Pro His Leu Val Ile 
                325                 330                 335     


Ile Ala Arg Asn Ala Phe Val Ala Phe Asn Thr Ala Thr Glu Ala Val 
            340                 345                 350         


Val Asn Val Thr Val Met Ser Ser Phe Gly Pro Asp Phe Phe Ala Phe 
        355                 360                 365             


Ser Glu Gly Pro Glu Ile Thr Gly Leu Lys Leu Thr Asp Ser Ala Trp 
    370                 375                 380                 


Val Ala Pro Lys Ser Asp Val Phe Gly Ala Ser Arg Ser Val Leu Thr 
385                 390                 395                 400 


Ser Tyr Gly Leu Glu Pro Asn Ala Val Ile Ala Ile Asp Gly Arg Ala 
                405                 410                 415     


Thr Pro Lys Glu Arg Ile Val Tyr Pro Ser Val Ile Leu His Phe Ala 
            420                 425                 430         


Ser Cys Asp Thr Phe Asn Glu Gly Ala Thr Ile Lys Asn Val Gly Met 
        435                 440                 445             


Trp Thr Tyr Gly Ala Asn Thr Val Val Gly Ser Pro Gly Val Arg Ser 
    450                 455                 460                 


Tyr Gly Thr Cys Phe Leu Glu Ile Thr Thr Arg Glu Asp Thr Gly Asn 
465                 470                 475                 480 


Glu Thr Ser Leu Thr Met Gln Leu His Leu Gly Thr Ala Thr Asp Pro 
                485                 490                 495     


Tyr Asn Ser Phe Gly Glu Ala Asn Thr Gln Tyr Met Gln Ala Glu Arg 
            500                 505                 510         


Tyr Tyr Gly Asp Phe Lys Ala Arg Ala Val Gly Val Val Glu Val Tyr 
        515                 520                 525             


Leu Thr Ala Thr Asp Ile Glu Pro Ser Leu Lys Ser Tyr Glu Phe Asp 
    530                 535                 540                 


Val Glu Leu Asp Ser Ile Arg Lys Ala Thr Val Thr Arg His Val Gly 
545                 550                 555                 560 


Asn Leu Ser Ser Asp Gly Thr Ile Asn Asn Tyr Tyr Met Val Phe Asp 
                565                 570                 575     


Asn Tyr Glu Ser Val Val Lys Val Leu Asp Ile Pro Leu Pro Gly Phe 
            580                 585                 590         


Lys Ser Met Thr Tyr Val Val Lys Ser Tyr Ala Val Asn Val Thr Phe 
        595                 600                 605             


Asp Phe Ser Ser Thr Ser Leu Ile Arg Gly Ile Thr Asn Gln Asp Ile 
    610                 615                 620                 


Thr Ile Leu Pro Gly Asn Ser Cys Asp Val Cys Val Ile Glu Pro Lys 
625                 630                 635                 640 


Asp Gly Val Leu Pro Asn Ile Pro Gln Thr Gly Ile Leu Thr Asp Asn 
                645                 650                 655     


Tyr Asn Thr Gly Pro Ser Leu Leu Asp Cys Pro Ser Leu Tyr His Tyr 
            660                 665                 670         


Leu Tyr Pro Ala Phe Asn Glu Asn Leu Val Arg Phe Asp Leu Val Glu 
        675                 680                 685             


Leu Val Thr Asn Thr Val Met Ala Thr Met Val Tyr His Pro Lys Ile 
    690                 695                 700                 


Lys Thr Val Phe Thr Thr His Arg Thr Ala Gly Ser Asn Asp Ser Gln 
705                 710                 715                 720 


Cys Tyr Met Val Ser Arg Tyr Xaa Ala Gly Gln Met Xaa Leu Ser Asn 
                725                 730                 735     


Val Gln Leu Leu Val Asp Asn Gly Asn Tyr Pro Ser Thr Gln Asp Val 
            740                 745                 750         


Val Gly Phe Val Thr Arg Leu Leu Gly Asp Ser Thr Ala Leu Val Arg 
        755                 760                 765             


Gly Ile Glu Ser Met Asn Val His Gly Asn Ala Glu Ala Leu Leu Gly 
    770                 775                 780                 


Ala Ser Thr Ala Val Asn Ala Leu Gln Pro Leu Ala Asn Tyr Tyr Gln 
785                 790                 795                 800 


Asn Lys Ala Asn Gln Asp Trp Tyr Trp Lys Gln Lys Gln Ala Glu Tyr 
                805                 810                 815     


Glu Gln Glu Gln Ala Leu Leu Ala Ala Lys Asn Lys Asn Ala Leu Asp 
            820                 825                 830         


Ile Ala Asn Val Gln Ala Gln Asn Gln Leu Asp Leu Gln Arg Ala Lys 
        835                 840                 845             


Leu Asp Ser Gln Tyr Gly Leu Ala Pro Ser Asn Gly Val Ser Thr Ser 
    850                 855                 860                 


Val Asn Ser Ser Ser Thr Val Pro Tyr Val Tyr His Ser Thr Leu Gly 
865                 870                 875                 880 


Ser Asn Val Pro Ser Asn Pro Ser Asp Ser Asp Glu Asn Asp Val Ser 
                885                 890                 895     


Arg Arg Ala Ile Ser Met Arg Asp Gly Lys Ile Asn Ile Ser Glu Gly 
            900                 905                 910         


Asn Arg Val Gln Pro Gly Pro Ser Thr Thr Ser Ser Val Ser Thr Ser 
        915                 920                 925             


Asp Glu Asn Thr Gly Gly Arg Val Ile Tyr Pro Thr Ser Thr Asn Pro 
    930                 935                 940                 


Asp Leu Thr Thr Met Ile Gln Gln Thr Ala Asn Lys Val Lys Gly Gly 
945                 950                 955                 960 


Asn Val Asp Ala Asn Gly Asp Leu Val Pro Ser Gly Asn Leu Ala Ser 
                965                 970                 975     


Leu Leu Lys Glu Asp Glu Tyr Arg Met Pro Asn Leu Asp Ala Gln Asp 
            980                 985                 990         


Leu Ile Asp Ala Lys Ala Asp Pro  Ala Gln Asn Leu Ala  Phe Gln Ser 
        995                 1000                 1005             


Asp Tyr  Ser Tyr Tyr Asn Ser  Pro Asp Thr Ser Thr  Asp Gly Leu 
    1010                 1015                 1020             


Gly Val  Thr Pro Gln Gly Pro  His Tyr Gln Val Glu  Asp Pro Gln 
    1025                 1030                 1035             


Glu Asn  Pro Pro Pro Val Pro  Lys Thr Trp Met Glu  Lys Trp Asn 
    1040                 1045                 1050             


Leu Ser  Lys His Ala Lys Ser  Ser Gly Leu Gln Ser  Ala Val Gln 
    1055                 1060                 1065             


Lys Leu  Gln Pro Lys 
    1070             


<210>  91
<211>  675
<212>  RNA
<213>  Dicistrovirus DVVv3

<400>  91
ccauuacggc cgggggaaaa uaagggcuau ggcgucaugc cauaguuuau auacaccacg       60

gauuacguga accuuguuag uaauaacggg ugcccuuugu uagggaugug uuuuaugaau      120

uauuaauuau guuauaacuc uuauuuucaa cuacgggauu aaaaccccac uuuaaaacua      180

uauagggaaa uuuaguuuaa accuguauag gaaauuaagg auugauaauu uuauugaacg      240

agccuacucg uugaauauuu auaguuaguu gugauaacua gccuuguauu uagacaugga      300

uaaucuccag cccauguucg acauaccuua ggaaguuuau augcggcacg uauucaauua      360

aaugaagaug cuauaagugc uugauuagac auuaaaacua gaacaaguuc ucuaguuguc      420

gcugguagag cauaacuuau aguaggugga uuuuauuuga ugacccaagu auuuaugaaa      480

uuugucggcc uccaaguuga ucagcuaauu auuuauauuu ugcgaguaau aguaguucag      540

acugugcuau ccccuugaca ugcauuuuuu gguuacucca gauugugaua uuagggcucu      600

aauauugcaa gacugcccac caaguaagga acuuauguaa acuugcuugg gaaacacauu      660

acucaaaaaa uuauu                                                       675


<210>  92
<211>  746
<212>  RNA
<213>  Dicistrovirus DVVv3

<400>  92
gguaaccuau uuggggaccu cacuuuuagu ugcuagcuaa caaugggggc cuuaaaauua       60

ucuuauuacc uuaauugguu guaagugcug aauuuuaagg gggccgcgca uauugcguag      120

uaagaccugg gccuugcaug uagcauuaua agucccacuc guuauagcuu aaaucguacc      180

uuagcccgua cgagacaaga agugaauuau auuuaaccac cauauauuaa ucauuuagua      240

uauaagguag auauuagaaa uuaaauaaua uagaaaugau gaauaaccua ucagcuuggu      300

aauugccuaa augcgucugu uuucuguguc aauuuuagcg uaagcuggcc uugacacuuu      360

uaaccggugc augaauagau uauuuuuaaa auuuguauuu uuacguaagu uugccuacaa      420

aauuuuacau uucgaaacaa ucaugaauag aauaacagua aaagugcguu agucacgugg      480

cgcaccuaua uuaacuuuuu uaacguuuau uucauuagua uagguuauuc auuauaauau      540

auuguacaua uacuauaauu cccaaauuua uguuuguuau uguacacccc cgauuagucg      600

guuuauauuu auauauuugg cucugcgaau gcaguuaaac gcuaccacuu uucggggacu      660

aucuaaucuu uauauaaaau uaguuagucg gauuuuaggg ccuucagccc ucuaaucuuu      720

uuauugaaaa aaaaaaaaaa aaaaaa                                           746


<210>  93
<211>  42
<212>  RNA
<213>  Dicistrovirus DVVv3


<220>
<221>  misc_RNA
<222>  (1)..(42)
<223>  IGR

<400>  93
cuaaggacac uuccucuuuu guaauccgua aagaucgaac aa                          42


<210>  94
<211>  10396
<212>  RNA
<213>  synthetic construct


<220>
<221>  5'UTR
<222>  (1)..(675)

<220>
<221>  CDS
<222>  (676)..(9192)
<223>  non-structural polyprotein, ORF1

<220>
<221>  promoter
<222>  (9193)..(9234)
<223>  intergenic region (IGR)

<220>
<221>  misc_RNA
<222>  (9235)..(9649)
<223>  Central region

<220>
<221>  3'UTR
<222>  (9651)..(10396)

<400>  94
ccauuacggc cgggggaaaa uaagggcuau ggcgucaugc cauaguuuau auacaccacg       60

gauuacguga accuuguuag uaauaacggg ugcccuuugu uagggaugug uuuuaugaau      120

uauuaauuau guuauaacuc uuauuuucaa cuacgggauu aaaaccccac uuuaaaacua      180

uauagggaaa uuuaguuuaa accuguauag gaaauuaagg auugauaauu uuauugaacg      240

agccuacucg uugaauauuu auaguuaguu gugauaacua gccuuguauu uagacaugga      300

uaaucuccag cccauguucg acauaccuua ggaaguuuau augcggcacg uauucaauua      360

aaugaagaug cuauaagugc uugauuagac auuaaaacua gaacaaguuc ucuaguuguc      420

gcugguagag cauaacuuau aguaggugga uuuuauuuga ugacccaagu auuuaugaaa      480

uuugucggcc uccaaguuga ucagcuaauu auuuauauuu ugcgaguaau aguaguucag      540

acugugcuau ccccuugaca ugcauuuuuu gguuacucca gauugugaua uuagggcucu      600

aauauugcaa gacugcccac caaguaagga acuuauguaa acuugcuugg gaaacacauu      660

acucaaaaaa uuauu aug gaa agu uca aau aag aau aug ugu acu gga uuc       711
                 Met Glu Ser Ser Asn Lys Asn Met Cys Thr Gly Phe          
                 1               5                   10                   

ccc caa acc cuu aaa auc uca acg gaa auu agu auc aua aac caa uca        759
Pro Gln Thr Leu Lys Ile Ser Thr Glu Ile Ser Ile Ile Asn Gln Ser           
        15                  20                  25                        

ucu caa acc ccc aga gau ugg ucu uau gua caa gaa aau aug caa cag        807
Ser Gln Thr Pro Arg Asp Trp Ser Tyr Val Gln Glu Asn Met Gln Gln           
    30                  35                  40                            

uuu aaa aau uau uua caa uua gca ugg auu gaa guu ccg aau aac auu        855
Phe Lys Asn Tyr Leu Gln Leu Ala Trp Ile Glu Val Pro Asn Asn Ile           
45                  50                  55                  60            

aca aua gga aau uuu gac guu uuu gaa gau aau aug cca auu gcu cac        903
Thr Ile Gly Asn Phe Asp Val Phe Glu Asp Asn Met Pro Ile Ala His           
                65                  70                  75                

gcu auu uca ucg gau uug cau caa aca gca ggu auu gcu ggu guu uua        951
Ala Ile Ser Ser Asp Leu His Gln Thr Ala Gly Ile Ala Gly Val Leu           
            80                  85                  90                    

aga caa aau uau uuu aaa aau cua ccu aaa guu aac gua aau aaa agu        999
Arg Gln Asn Tyr Phe Lys Asn Leu Pro Lys Val Asn Val Asn Lys Ser           
        95                  100                 105                       

aau auu gga acc uua uau uug uau cca aau aaa aau uua acu cga caa       1047
Asn Ile Gly Thr Leu Tyr Leu Tyr Pro Asn Lys Asn Leu Thr Arg Gln           
    110                 115                 120                           

auu auu gga uug auu acu aaa gau auu uau uau uua aaa cca acu uau       1095
Ile Ile Gly Leu Ile Thr Lys Asp Ile Tyr Tyr Leu Lys Pro Thr Tyr           
125                 130                 135                 140           

gcu uca cuu uuu aca acu uua auu gaa uug cgu aaa uau cuu auu aau       1143
Ala Ser Leu Phe Thr Thr Leu Ile Glu Leu Arg Lys Tyr Leu Ile Asn           
                145                 150                 155               

aau aaa aua aaa aau auu ugc cua ccu aug gua ggu ugu aau aaa gau       1191
Asn Lys Ile Lys Asn Ile Cys Leu Pro Met Val Gly Cys Asn Lys Asp           
            160                 165                 170                   

aaa uua aau ccu cuu gca guu uua ccc aug cua aug uau ugc cuc ggc       1239
Lys Leu Asn Pro Leu Ala Val Leu Pro Met Leu Met Tyr Cys Leu Gly           
        175                 180                 185                       

aau auu gaa acu caa gua aaa aua acu aau aaa gga guu uau uuu aau       1287
Asn Ile Glu Thr Gln Val Lys Ile Thr Asn Lys Gly Val Tyr Phe Asn           
    190                 195                 200                           

uau caa cca auu ccu guu gcu cca aaa auu aau aaa auu aaa uuu agu       1335
Tyr Gln Pro Ile Pro Val Ala Pro Lys Ile Asn Lys Ile Lys Phe Ser           
205                 210                 215                 220           

aaa caa aug gaa aaa guu aau uau gau caa acu gua gau acu uuu gaa       1383
Lys Gln Met Glu Lys Val Asn Tyr Asp Gln Thr Val Asp Thr Phe Glu           
                225                 230                 235               

aca aau uau guu aaa ccu aag aaa uuc aaa gcu aaa gua aca uuu gaa       1431
Thr Asn Tyr Val Lys Pro Lys Lys Phe Lys Ala Lys Val Thr Phe Glu           
            240                 245                 250                   

ccc ucu cuu uua aau cuu gau ucu aau agu auu aua auu aau gaa agu       1479
Pro Ser Leu Leu Asn Leu Asp Ser Asn Ser Ile Ile Ile Asn Glu Ser           
        255                 260                 265                       

aag aca gua aaa caa auu uau aaa gcu aaa uua gaa aaa gua aua uau       1527
Lys Thr Val Lys Gln Ile Tyr Lys Ala Lys Leu Glu Lys Val Ile Tyr           
    270                 275                 280                           

caa aga ucu aca guu uau gaa cca caa aag aag aca uau gug gua gaa       1575
Gln Arg Ser Thr Val Tyr Glu Pro Gln Lys Lys Thr Tyr Val Val Glu           
285                 290                 295                 300           

gcu uuu ucu ugu aaa caa ccu aaa cca auu guc aaa auu uuu aaa aug       1623
Ala Phe Ser Cys Lys Gln Pro Lys Pro Ile Val Lys Ile Phe Lys Met           
                305                 310                 315               

aaa caa gca auu uua acu caa acu gac uua aaa gaa aau aau aau gaa       1671
Lys Gln Ala Ile Leu Thr Gln Thr Asp Leu Lys Glu Asn Asn Asn Glu           
            320                 325                 330                   

cua auu aaa gaa aga aau agu auu gau uau uau aaa uuu guu aca ccu       1719
Leu Ile Lys Glu Arg Asn Ser Ile Asp Tyr Tyr Lys Phe Val Thr Pro           
        335                 340                 345                       

aac acc guu aaa gcu auu auc gga uac gac aaa gua gaa uca guu uug       1767
Asn Thr Val Lys Ala Ile Ile Gly Tyr Asp Lys Val Glu Ser Val Leu           
    350                 355                 360                           

aca uuu gau uug gau cgu aaa cgu aga ugu gga gaa aaa gcu uuu gua       1815
Thr Phe Asp Leu Asp Arg Lys Arg Arg Cys Gly Glu Lys Ala Phe Val           
365                 370                 375                 380           

cau gga aaa ucu uua aaa uca aua gcu aaa cga caa cug ugu uau agu       1863
His Gly Lys Ser Leu Lys Ser Ile Ala Lys Arg Gln Leu Cys Tyr Ser           
                385                 390                 395               

uau gua cca ucu cua aac uca gug caa gua uau auu aaa aug uua caa       1911
Tyr Val Pro Ser Leu Asn Ser Val Gln Val Tyr Ile Lys Met Leu Gln           
            400                 405                 410                   

uua acg gcg cag aaa caa gua uuu ggu cau gua gua acg aaa auu caa       1959
Leu Thr Ala Gln Lys Gln Val Phe Gly His Val Val Thr Lys Ile Gln           
        415                 420                 425                       

gaa agu auu gcc aau aug gau guu cau gga aug caa auu aac aau aua       2007
Glu Ser Ile Ala Asn Met Asp Val His Gly Met Gln Ile Asn Asn Ile           
    430                 435                 440                           

ccu gaa gaa uua aug aaa uca uua ucc aga aca auu uua gaa caa uua       2055
Pro Glu Glu Leu Met Lys Ser Leu Ser Arg Thr Ile Leu Glu Gln Leu           
445                 450                 455                 460           

caa uua gac acu aaa gua aua aaa cca guu uug uua gca aau aua uua       2103
Gln Leu Asp Thr Lys Val Ile Lys Pro Val Leu Leu Ala Asn Ile Leu           
                465                 470                 475               

aau ugu uuc gua aau guu guu ugu gcc uua aua aua aua uuc acu gcc       2151
Asn Cys Phe Val Asn Val Val Cys Ala Leu Ile Ile Ile Phe Thr Ala           
            480                 485                 490                   

aaa agu aaa guu gca ucu gga gca gcu auu guu caa aua auu uca aau       2199
Lys Ser Lys Val Ala Ser Gly Ala Ala Ile Val Gln Ile Ile Ser Asn           
        495                 500                 505                       

auu uua acc uua aug uug gau aua ggc auu uau uau uca cuu aaa cau       2247
Ile Leu Thr Leu Met Leu Asp Ile Gly Ile Tyr Tyr Ser Leu Lys His           
    510                 515                 520                           

aug acc gaa gaa aga auu aaa gca aua acu acg acu aua aca cag gau       2295
Met Thr Glu Glu Arg Ile Lys Ala Ile Thr Thr Thr Ile Thr Gln Asp           
525                 530                 535                 540           

gcu guc caa aaa gua aug aaa caa cau ggc gua acu aug aug gca ucu       2343
Ala Val Gln Lys Val Met Lys Gln His Gly Val Thr Met Met Ala Ser           
                545                 550                 555               

gau aaa gua aua aca gcc aug caa aau guc gau uua aau gau gcu aaa       2391
Asp Lys Val Ile Thr Ala Met Gln Asn Val Asp Leu Asn Asp Ala Lys           
            560                 565                 570                   

uca aua aag cau uuu aua aaa gaa uuc gaa aaa gaa gaa gau acc gac       2439
Ser Ile Lys His Phe Ile Lys Glu Phe Glu Lys Glu Glu Asp Thr Asp           
        575                 580                 585                       

auu uca gaa auu uca ccc gau ugu gua cca aac uau ucu gau aug uua       2487
Ile Ser Glu Ile Ser Pro Asp Cys Val Pro Asn Tyr Ser Asp Met Leu           
    590                 595                 600                           

ccu auu gga uua caa aug aaa aag aag aac agg cuu gau aug gau uuu       2535
Pro Ile Gly Leu Gln Met Lys Lys Lys Asn Arg Leu Asp Met Asp Phe           
605                 610                 615                 620           

guu uug aug gac aaa aua gca guu guu gau cca acg ggu aag uua aug       2583
Val Leu Met Asp Lys Ile Ala Val Val Asp Pro Thr Gly Lys Leu Met           
                625                 630                 635               

aag aua guu agu gac ugu cca uac gac aca ccu agu aaa aau aau cag       2631
Lys Ile Val Ser Asp Cys Pro Tyr Asp Thr Pro Ser Lys Asn Asn Gln           
            640                 645                 650                   

ugu uug cuc cac ucc cuu cug ggu gca cua gau cau aga gau aga aaa       2679
Cys Leu Leu His Ser Leu Leu Gly Ala Leu Asp His Arg Asp Arg Lys           
        655                 660                 665                       

guu uua gug gau gaa agu aau auu gaa aaa uuc uuc caa ugg aug ucc       2727
Val Leu Val Asp Glu Ser Asn Ile Glu Lys Phe Phe Gln Trp Met Ser           
    670                 675                 680                           

gau aau auu agu gau cca gau gug auu gaa gca auu aau guu uau aaa       2775
Asp Asn Ile Ser Asp Pro Asp Val Ile Glu Ala Ile Asn Val Tyr Lys           
685                 690                 695                 700           

aug gag uau gcu ucu gau uuc cca cca gaa gca acu aau uua gau guu       2823
Met Glu Tyr Ala Ser Asp Phe Pro Pro Glu Ala Thr Asn Leu Asp Val           
                705                 710                 715               

uua caa gga auu aaa acu cau aag aaa aug uua cca guu gac cuu ugu       2871
Leu Gln Gly Ile Lys Thr His Lys Lys Met Leu Pro Val Asp Leu Cys           
            720                 725                 730                   

aaa uua cuc uca aaa uau uug gac cgu acu aua auu gua aaa cau gua       2919
Lys Leu Leu Ser Lys Tyr Leu Asp Arg Thr Ile Ile Val Lys His Val           
        735                 740                 745                       

aau aaa guu uug acu uau gga ccg gaa aga ugg gau aac aau aua cca       2967
Asn Lys Val Leu Thr Tyr Gly Pro Glu Arg Trp Asp Asn Asn Ile Pro           
    750                 755                 760                           

aaa aua cuc caa uua gaa aau caa cau uuu agc uau auu gac cga gua       3015
Lys Ile Leu Gln Leu Glu Asn Gln His Phe Ser Tyr Ile Asp Arg Val           
765                 770                 775                 780           

cua gug gau aau auu uug cca uua aaa gca gca guu gag ugu aug guu       3063
Leu Val Asp Asn Ile Leu Pro Leu Lys Ala Ala Val Glu Cys Met Val           
                785                 790                 795               

caa uuu acu uua aca cga gcc gca caa uuu aau aca ccc gau aca cuu       3111
Gln Phe Thr Leu Thr Arg Ala Ala Gln Phe Asn Thr Pro Asp Thr Leu           
            800                 805                 810                   

aaa caa aaa gag uau uau uua gcg aug gca gca gca uac guu uuu aca       3159
Lys Gln Lys Glu Tyr Tyr Leu Ala Met Ala Ala Ala Tyr Val Phe Thr           
        815                 820                 825                       

uau aau ucu aga auu gcu gug ugu ugu aug aau gug aaa ucu aau aag       3207
Tyr Asn Ser Arg Ile Ala Val Cys Cys Met Asn Val Lys Ser Asn Lys           
    830                 835                 840                           

cuu gau gcg aaa uca auu auu ggu auu ugc aca gau auu cug ucu aca       3255
Leu Asp Ala Lys Ser Ile Ile Gly Ile Cys Thr Asp Ile Leu Ser Thr           
845                 850                 855                 860           

auu gcu uuc gua guu ggu aug gga gua ucu agu ggu gau uuu gca uca       3303
Ile Ala Phe Val Val Gly Met Gly Val Ser Ser Gly Asp Phe Ala Ser           
                865                 870                 875               

cgc aug gua aag gcu gag aaa uuu uca aca ucu aug gau aca uuu gca       3351
Arg Met Val Lys Ala Glu Lys Phe Ser Thr Ser Met Asp Thr Phe Ala           
            880                 885                 890                   

ucu agg aca acu aau aag uua gau ucg auu uua ucg aaa gcu uuc ggu       3399
Ser Arg Thr Thr Asn Lys Leu Asp Ser Ile Leu Ser Lys Ala Phe Gly           
        895                 900                 905                       

auu uau aug ucg gaa gau ggc gaa acg guu gca agu uua ucc aaa gau       3447
Ile Tyr Met Ser Glu Asp Gly Glu Thr Val Ala Ser Leu Ser Lys Asp           
    910                 915                 920                           

auu gau aua cua gag aaa uau aaa gca cau acu gua gcc gau uau aug       3495
Ile Asp Ile Leu Glu Lys Tyr Lys Ala His Thr Val Ala Asp Tyr Met           
925                 930                 935                 940           

aau aau aug uca aaa uau caa gaa guu aaa aca uau gua gaa gga guu       3543
Asn Asn Met Ser Lys Tyr Gln Glu Val Lys Thr Tyr Val Glu Gly Val           
                945                 950                 955               

aca aaa cgu aug aca uca cua cac cua uua aau aga gau acc acu aau       3591
Thr Lys Arg Met Thr Ser Leu His Leu Leu Asn Arg Asp Thr Thr Asn           
            960                 965                 970                   

gcu auu caa aau acg caa aau auu aua aga aag agu ugu gau gcc aua       3639
Ala Ile Gln Asn Thr Gln Asn Ile Ile Arg Lys Ser Cys Asp Ala Ile           
        975                 980                 985                       

aug gca guu uug aau gac guu gau aag uug aau aga  aug gaa uca uug      3687
Met Ala Val Leu Asn Asp Val Asp Lys Leu Asn Arg  Met Glu Ser Leu          
    990                 995                 1000                          

aga  cag gaa uuu gug ggc  cuu aag gga gcu ggu  aaa acc uca aca        3732
Arg  Gln Glu Phe Val Gly  Leu Lys Gly Ala Gly  Lys Thr Ser Thr            
1005                 1010                 1015                            

uug  aac aau uau cua aua  cca aau auu gcu aag  cgc uug gcg uug        3777
Leu  Asn Asn Tyr Leu Ile  Pro Asn Ile Ala Lys  Arg Leu Ala Leu            
1020                 1025                 1030                            

aau  cca agc acc uau gca  gca gaa auu gac gcg  aau gga cau ugg        3822
Asn  Pro Ser Thr Tyr Ala  Ala Glu Ile Asp Ala  Asn Gly His Trp            
1035                 1040                 1045                            

aaa  ccc uau aga uau gaa  gau uuu gcu uua aua  gau gau uug uuu        3867
Lys  Pro Tyr Arg Tyr Glu  Asp Phe Ala Leu Ile  Asp Asp Leu Phe            
1050                 1055                 1060                            

aau  cag ggu agu aac gac  ccc uuu aua cca cau  auu gua agg aug        3912
Asn  Gln Gly Ser Asn Asp  Pro Phe Ile Pro His  Ile Val Arg Met            
1065                 1070                 1075                            

gcu  ucc ucu cuu aac uuu  gau uua ccu gga gcu  gac uug agc aau        3957
Ala  Ser Ser Leu Asn Phe  Asp Leu Pro Gly Ala  Asp Leu Ser Asn            
1080                 1085                 1090                            

aaa  gag aaa acu uua agg  gcu aga uuc uug uuu  gcg aca gca aac        4002
Lys  Glu Lys Thr Leu Arg  Ala Arg Phe Leu Phe  Ala Thr Ala Asn            
1095                 1100                 1105                            

guu  gca uau gua aga aug  aag gaa gaa aug ccc  gcu agu gcu cag        4047
Val  Ala Tyr Val Arg Met  Lys Glu Glu Met Pro  Ala Ser Ala Gln            
1110                 1115                 1120                            

gaa  gga uuu uau ggu aga  uuu aag ugu auu caa  uuu auu aau gcc        4092
Glu  Gly Phe Tyr Gly Arg  Phe Lys Cys Ile Gln  Phe Ile Asn Ala            
1125                 1130                 1135                            

aaa  caa ggu auu aau cag  gca aga gau uca gug  gaa uac auc gac        4137
Lys  Gln Gly Ile Asn Gln  Ala Arg Asp Ser Val  Glu Tyr Ile Asp            
1140                 1145                 1150                            

uau  gaa gau cau gau aca  uau gaa uug aga aug  uau gaa gaa caa        4182
Tyr  Glu Asp His Asp Thr  Tyr Glu Leu Arg Met  Tyr Glu Glu Gln            
1155                 1160                 1165                            

auu  aau gaa caa uuc uca  cag auu gaa aga aau  gac cau aua acu        4227
Ile  Asn Glu Gln Phe Ser  Gln Ile Glu Arg Asn  Asp His Ile Thr            
1170                 1175                 1180                            

ggu  gaa cgu aua caa cau  uuu gau ccu ucu acu  aag acu uau gau        4272
Gly  Glu Arg Ile Gln His  Phe Asp Pro Ser Thr  Lys Thr Tyr Asp            
1185                 1190                 1195                            

gac  cau auu uac aaa aua  gga cau uua cau uau  aaa auu gua acc        4317
Asp  His Ile Tyr Lys Ile  Gly His Leu His Tyr  Lys Ile Val Thr            
1200                 1205                 1210                            

uuu  aaa cag uua gaa aca  auu ugu aua gau cag  uuu aau aaa aag        4362
Phe  Lys Gln Leu Glu Thr  Ile Cys Ile Asp Gln  Phe Asn Lys Lys            
1215                 1220                 1225                            

uau  caa cau uac aaa aug  gcu aga gau cgu aaa  ugu gua gug gac        4407
Tyr  Gln His Tyr Lys Met  Ala Arg Asp Arg Lys  Cys Val Val Asp            
1230                 1235                 1240                            

uuu  gaa uau uuu aga aau  auu gau aug aaa uca  gac gca aua gua        4452
Phe  Glu Tyr Phe Arg Asn  Ile Asp Met Lys Ser  Asp Ala Ile Val            
1245                 1250                 1255                            

gaa  aau aug gua cgu aag  ggu uau cuc cca gca  gaa auu gaa gca        4497
Glu  Asn Met Val Arg Lys  Gly Tyr Leu Pro Ala  Glu Ile Glu Ala            
1260                 1265                 1270                            

gca  aga caa acu gua gga  cuu aca gcu gga cca  gau gaa gug cau        4542
Ala  Arg Gln Thr Val Gly  Leu Thr Ala Gly Pro  Asp Glu Val His            
1275                 1280                 1285                            

gcc  aaa ucu gaa ucu aua  auu aau cau uac guu  gua uca guu uuu        4587
Ala  Lys Ser Glu Ser Ile  Ile Asn His Tyr Val  Val Ser Val Phe            
1290                 1295                 1300                            

ggc  gau acu gga acu gga  aaa ucu guu uuu gcu  aca cag cug gcg        4632
Gly  Asp Thr Gly Thr Gly  Lys Ser Val Phe Ala  Thr Gln Leu Ala            
1305                 1310                 1315                            

uua  gau cug uca gac uuu  cug aau uug aaa gua  uau ucu gug gaa        4677
Leu  Asp Leu Ser Asp Phe  Leu Asn Leu Lys Val  Tyr Ser Val Glu            
1320                 1325                 1330                            

gau  aua aau gau acg gcc  cau uua gac uac uua  aau cca agu aua        4722
Asp  Ile Asn Asp Thr Ala  His Leu Asp Tyr Leu  Asn Pro Ser Ile            
1335                 1340                 1345                            

auu  guu uuc cau gau agc  auu uau gau gaa uug  aaa uau guu gca        4767
Ile  Val Phe His Asp Ser  Ile Tyr Asp Glu Leu  Lys Tyr Val Ala            
1350                 1355                 1360                            

uua  uau gau aaa uua cca  aaa cca ugu uua aua  aua acu aca agu        4812
Leu  Tyr Asp Lys Leu Pro  Lys Pro Cys Leu Ile  Ile Thr Thr Ser            
1365                 1370                 1375                            

aau  cau aca uua aaa ugg  cau aga gag aaa uua  ugu aau auu guu        4857
Asn  His Thr Leu Lys Trp  His Arg Glu Lys Leu  Cys Asn Ile Val            
1380                 1385                 1390                            

gau  aau agu acu uca gca  gca gag cgc ucu ucu  agu gcu uug uug        4902
Asp  Asn Ser Thr Ser Ala  Ala Glu Arg Ser Ser  Ser Ala Leu Leu            
1395                 1400                 1405                            

gaa  cau ggu uuc uuu aac  aaa aug aaa aau aaa  auu ggc gga cuu        4947
Glu  His Gly Phe Phe Asn  Lys Met Lys Asn Lys  Ile Gly Gly Leu            
1410                 1415                 1420                            

guu  ucu uau uuu aau uug  uca agu auu aga gaa  ggu uau uug guu        4992
Val  Ser Tyr Phe Asn Leu  Ser Ser Ile Arg Glu  Gly Tyr Leu Val            
1425                 1430                 1435                            

caa  aca uuc cca gga uac  caa cca aca ccu ggu  uau ugu aga aga        5037
Gln  Thr Phe Pro Gly Tyr  Gln Pro Thr Pro Gly  Tyr Cys Arg Arg            
1440                 1445                 1450                            

cua  ggu uug aac acu gca  uuc cac ccg aua ucg  aca gaa gau uug        5082
Leu  Gly Leu Asn Thr Ala  Phe His Pro Ile Ser  Thr Glu Asp Leu            
1455                 1460                 1465                            

aca  ucu aau uua gua uau  uca cag cgu ccu aau  aaa gaa acu aca        5127
Thr  Ser Asn Leu Val Tyr  Ser Gln Arg Pro Asn  Lys Glu Thr Thr            
1470                 1475                 1480                            

acc  auu uuu gca acu uca  gga uac cau uuc cau  cag gau aau aaa        5172
Thr  Ile Phe Ala Thr Ser  Gly Tyr His Phe His  Gln Asp Asn Lys            
1485                 1490                 1495                            

gaa  gug caa uua aac gaa  guc guu aaa gaa guu  uua aug aaa uau        5217
Glu  Val Gln Leu Asn Glu  Val Val Lys Glu Val  Leu Met Lys Tyr            
1500                 1505                 1510                            

aga  gga gcu aag aaa uuc  auu cag ccu gau auu  auc aaa uua gga        5262
Arg  Gly Ala Lys Lys Phe  Ile Gln Pro Asp Ile  Ile Lys Leu Gly            
1515                 1520                 1525                            

gua  uca gaa uuu gag gaa  caa uuu aag aaa uua  aca acu auu gau        5307
Val  Ser Glu Phe Glu Glu  Gln Phe Lys Lys Leu  Thr Thr Ile Asp            
1530                 1535                 1540                            

gua  gaa auu cag ucu aaa  aau auu gag uca uug  auu aaa uua acg        5352
Val  Glu Ile Gln Ser Lys  Asn Ile Glu Ser Leu  Ile Lys Leu Thr            
1545                 1550                 1555                            

aac  gau aga gcu aua cua  gua aac ucu gua acu  gca gcu aga uuu        5397
Asn  Asp Arg Ala Ile Leu  Val Asn Ser Val Thr  Ala Ala Arg Phe            
1560                 1565                 1570                            

guu  ggu ggu ucu aau auu  guu aaa guu ucc agu  aga guc aga uca        5442
Val  Gly Gly Ser Asn Ile  Val Lys Val Ser Ser  Arg Val Arg Ser            
1575                 1580                 1585                            

aau  aau uau ucu uuu aau  ccu cua gau uuu gcu  auu ccu auu aau        5487
Asn  Asn Tyr Ser Phe Asn  Pro Leu Asp Phe Ala  Ile Pro Ile Asn            
1590                 1595                 1600                            

gcu  acu gua ucu gau gca  cua gau aua gca aug  aaa ucu uau agg        5532
Ala  Thr Val Ser Asp Ala  Leu Asp Ile Ala Met  Lys Ser Tyr Arg            
1605                 1610                 1615                            

cua  uua uug agu gca aau  gua gau uau aca gua  uuu auc aaa ugu        5577
Leu  Leu Leu Ser Ala Asn  Val Asp Tyr Thr Val  Phe Ile Lys Cys            
1620                 1625                 1630                            

gaa  gaa uuu ucu ugu aua  ggu auu aac ggc aau  auu uac uau acu        5622
Glu  Glu Phe Ser Cys Ile  Gly Ile Asn Gly Asn  Ile Tyr Tyr Thr            
1635                 1640                 1645                            

uca  gua ccu uuu aau gua  acu ucu uau uca cau  auu gca acu aaa        5667
Ser  Val Pro Phe Asn Val  Thr Ser Tyr Ser His  Ile Ala Thr Lys            
1650                 1655                 1660                            

gua  aua aca uuu uau aaa  gua gau acu aau uca  gau gga aua aca        5712
Val  Ile Thr Phe Tyr Lys  Val Asp Thr Asn Ser  Asp Gly Ile Thr            
1665                 1670                 1675                            

aau  aau uca gaa uua auc  aaa uuu aca ccg gau  gaa uau gcu aaa        5757
Asn  Asn Ser Glu Leu Ile  Lys Phe Thr Pro Asp  Glu Tyr Ala Lys            
1680                 1685                 1690                            

uua  auu auu aca gga gaa  gga gaa caa aaa cuu  uuu gau aag uug        5802
Leu  Ile Ile Thr Gly Glu  Gly Glu Gln Lys Leu  Phe Asp Lys Leu            
1695                 1700                 1705                            

ccu  uau gca gcu ugu aaa  uau auu uau ggc gcu  aga gca gag auu        5847
Pro  Tyr Ala Ala Cys Lys  Tyr Ile Tyr Gly Ala  Arg Ala Glu Ile            
1710                 1715                 1720                            

gaa  cca cau uuu gcg aca  aca uuu acu aaa uac  gaa guu aga aca        5892
Glu  Pro His Phe Ala Thr  Thr Phe Thr Lys Tyr  Glu Val Arg Thr            
1725                 1730                 1735                            

gaa  guu uau gau aau cau  acu aga gag aaa aug  gcu uuc uuu gua        5937
Glu  Val Tyr Asp Asn His  Thr Arg Glu Lys Met  Ala Phe Phe Val            
1740                 1745                 1750                            

auu  uau uca gaa uuu aag  aaa aca auu ugg uau  aaa aua gcu aua        5982
Ile  Tyr Ser Glu Phe Lys  Lys Thr Ile Trp Tyr  Lys Ile Ala Ile            
1755                 1760                 1765                            

ggu  auu uug gcu aua acu  gca uca guu uua aua  auu gaa uua aua        6027
Gly  Ile Leu Ala Ile Thr  Ala Ser Val Leu Ile  Ile Glu Leu Ile            
1770                 1775                 1780                            

aca  caa auu ugg aau aug  uuu auu ggu uua aaa  gaa guu uuu aca        6072
Thr  Gln Ile Trp Asn Met  Phe Ile Gly Leu Lys  Glu Val Phe Thr            
1785                 1790                 1795                            

agu  acc guu caa aaa gau  aau guu aaa gua guu  uau caa guu uua        6117
Ser  Thr Val Gln Lys Asp  Asn Val Lys Val Val  Tyr Gln Val Leu            
1800                 1805                 1810                            

uca  guu aau ccu aaa gag  caa uca gca gaa guu  aaa guu uau ggu        6162
Ser  Val Asn Pro Lys Glu  Gln Ser Ala Glu Val  Lys Val Tyr Gly            
1815                 1820                 1825                            

uuu  aaa gau gau uua gau  uca uuc ucu aau aaa  gag uua ucc aau        6207
Phe  Lys Asp Asp Leu Asp  Ser Phe Ser Asn Lys  Glu Leu Ser Asn            
1830                 1835                 1840                            

uua  auu aua gau gau auu  gau guu gcg aaa uua  gau gau uca auc        6252
Leu  Ile Ile Asp Asp Ile  Asp Val Ala Lys Leu  Asp Asp Ser Ile            
1845                 1850                 1855                            

ccc  gca gau acu gua auu  aaa gcc uug gau aug  ucg caa aug acu        6297
Pro  Ala Asp Thr Val Ile  Lys Ala Leu Asp Met  Ser Gln Met Thr            
1860                 1865                 1870                            

gug  cau agu gau ugg aau  aag aaa gac uuu gcu  aaa aac aaa gua        6342
Val  His Ser Asp Trp Asn  Lys Lys Asp Phe Ala  Lys Asn Lys Val            
1875                 1880                 1885                            

ccu  aca uug guc cau aga  aug uug gau aug cgc  guu cau agc gau        6387
Pro  Thr Leu Val His Arg  Met Leu Asp Met Arg  Val His Ser Asp            
1890                 1895                 1900                            

aaa  ucc cag gau aau aag  aaa auu ucu agg aag  gcu aac cgu gug        6432
Lys  Ser Gln Asp Asn Lys  Lys Ile Ser Arg Lys  Ala Asn Arg Val            
1905                 1910                 1915                            

gag  aga auu uua gaa aau  aug aca guu aaa ggu  gaa uuc gau uuu        6477
Glu  Arg Ile Leu Glu Asn  Met Thr Val Lys Gly  Glu Phe Asp Phe            
1920                 1925                 1930                            

auu  aaa cau aaa auu aca  aac ucu cuc ggc aag  guu guu guu ucc        6522
Ile  Lys His Lys Ile Thr  Asn Ser Leu Gly Lys  Val Val Val Ser            
1935                 1940                 1945                            

gca  agc ggu gua guu aag  acg guc gua ggu aug  aac auu aaa gga        6567
Ala  Ser Gly Val Val Lys  Thr Val Val Gly Met  Asn Ile Lys Gly            
1950                 1955                 1960                            

cau  uau gua auu ugu cca  gca cau guu uau cca  guu gau aca gcg        6612
His  Tyr Val Ile Cys Pro  Ala His Val Tyr Pro  Val Asp Thr Ala            
1965                 1970                 1975                            

uuc  cau uau gca aau uuu  acc ccg uuu aau acg  ggu aaa aau uac        6657
Phe  His Tyr Ala Asn Phe  Thr Pro Phe Asn Thr  Gly Lys Asn Tyr            
1980                 1985                 1990                            

aca  aug guc cca aug guc  ugu agu aga gua gau  gau uug gcu uug        6702
Thr  Met Val Pro Met Val  Cys Ser Arg Val Asp  Asp Leu Ala Leu            
1995                 2000                 2005                            

uuu  uac aua acu gau aaa  uua cau cca uua gcg  aaa gau auu aca        6747
Phe  Tyr Ile Thr Asp Lys  Leu His Pro Leu Ala  Lys Asp Ile Thr            
2010                 2015                 2020                            

cau  cau uuu gau gau cag  gaa cgu uua uau acu  cga cca uuc gag        6792
His  His Phe Asp Asp Gln  Glu Arg Leu Tyr Thr  Arg Pro Phe Glu            
2025                 2030                 2035                            

uug  ccu uau aug cau uua  cga acu ggu aau gua  gua ucu ugg aaa        6837
Leu  Pro Tyr Met His Leu  Arg Thr Gly Asn Val  Val Ser Trp Lys            
2040                 2045                 2050                            

ggu  gga gau gcu auu gga  uug cga uca uug guu  aca aaa guu cau        6882
Gly  Gly Asp Ala Ile Gly  Leu Arg Ser Leu Val  Thr Lys Val His            
2055                 2060                 2065                            

caa  gac aug uua uua aca  gaa gga aaa ccu aug  gua gca ggu caa        6927
Gln  Asp Met Leu Leu Thr  Glu Gly Lys Pro Met  Val Ala Gly Gln            
2070                 2075                 2080                            

uuu  ugg agu acg guu acu  cgc cuu acu aaa ggc  gau ugu gga uuc        6972
Phe  Trp Ser Thr Val Thr  Arg Leu Thr Lys Gly  Asp Cys Gly Phe            
2085                 2090                 2095                            

cca  aua aua gau acu aac  ucu cau aaa aua uuu  ucu auu uau ugu        7017
Pro  Ile Ile Asp Thr Asn  Ser His Lys Ile Phe  Ser Ile Tyr Cys            
2100                 2105                 2110                            

gga  gau aau aau ggc guu  aau gcu auu uau gga  aau aug gua aca        7062
Gly  Asp Asn Asn Gly Val  Asn Ala Ile Tyr Gly  Asn Met Val Thr            
2115                 2120                 2125                            

uca  aca uug guu aag aaa  aug auu gac uuu gcu  gaa ggu gua ucu        7107
Ser  Thr Leu Val Lys Lys  Met Ile Asp Phe Ala  Glu Gly Val Ser            
2130                 2135                 2140                            

gaa  gua cac gcu uuu acu  cgu uau agu cca ccc  aug gaa gag uuc        7152
Glu  Val His Ala Phe Thr  Arg Tyr Ser Pro Pro  Met Glu Glu Phe            
2145                 2150                 2155                            

uuu  gau gca gaa gau acu  ggu guu aug aag uuu  ucc uau cca ucu        7197
Phe  Asp Ala Glu Asp Thr  Gly Val Met Lys Phe  Ser Tyr Pro Ser            
2160                 2165                 2170                            

gga  gaa caa cau auu guu  aug ccu guu gaa acu  ugu gau uau auc        7242
Gly  Glu Gln His Ile Val  Met Pro Val Glu Thr  Cys Asp Tyr Ile            
2175                 2180                 2185                            

uca  aaa gca uau gaa acu  gaa aac uau uac ccu  ugc aug gau gga        7287
Ser  Lys Ala Tyr Glu Thr  Glu Asn Tyr Tyr Pro  Cys Met Asp Gly            
2190                 2195                 2200                            

gaa  uuu acg agg aau auc  gcg uac agu agu gau  ugu caa aag aac        7332
Glu  Phe Thr Arg Asn Ile  Ala Tyr Ser Ser Asp  Cys Gln Lys Asn            
2205                 2210                 2215                            

gca  uuu aug aaa ccu aaa  uau caa cga aca ccu  uuu gcu gaa gaa        7377
Ala  Phe Met Lys Pro Lys  Tyr Gln Arg Thr Pro  Phe Ala Glu Glu            
2220                 2225                 2230                            

auu  uua acu caa uau cca  caa auu aaa gau gau  ugu aga aau gcc        7422
Ile  Leu Thr Gln Tyr Pro  Gln Ile Lys Asp Asp  Cys Arg Asn Ala            
2235                 2240                 2245                            

gcu  acu gac cca agg uua  gua gaa gau aaa uca  aaa uua gua aau        7467
Ala  Thr Asp Pro Arg Leu  Val Glu Asp Lys Ser  Lys Leu Val Asn            
2250                 2255                 2260                            

uca  guu aaa gga gac cca  uca auu guu aug aca  caa cug gca aag        7512
Ser  Val Lys Gly Asp Pro  Ser Ile Val Met Thr  Gln Leu Ala Lys            
2265                 2270                 2275                            

auu  aau gac ccc aua gau  gca gcu ggu gga cuu  aug ggu gag aag        7557
Ile  Asn Asp Pro Ile Asp  Ala Ala Gly Gly Leu  Met Gly Glu Lys            
2280                 2285                 2290                            

uuu  aug gaa gaa gca gcu  gaa aug uua aca gaa  gag uau auu gac        7602
Phe  Met Glu Glu Ala Ala  Glu Met Leu Thr Glu  Glu Tyr Ile Asp            
2295                 2300                 2305                            

uug  uau agc ggu uuu gac  cau aga uuu uug acu  aca gaa gaa acg        7647
Leu  Tyr Ser Gly Phe Asp  His Arg Phe Leu Thr  Thr Glu Glu Thr            
2310                 2315                 2320                            

aua  aau ggu auu gca agu  ccu caa ucg gau uua  caa ggu cau uua        7692
Ile  Asn Gly Ile Ala Ser  Pro Gln Ser Asp Leu  Gln Gly His Leu            
2325                 2330                 2335                            

gaa  gcu gua aau aga gau  gcg ucu gca ggu cau  ugg ugu aug cua        7737
Glu  Ala Val Asn Arg Asp  Ala Ser Ala Gly His  Trp Cys Met Leu            
2340                 2345                 2350                            

aau  gga uau cau aaa auu  ucu gau uua uua gaa  gaa ggu ggu agu        7782
Asn  Gly Tyr His Lys Ile  Ser Asp Leu Leu Glu  Glu Gly Gly Ser            
2355                 2360                 2365                            

uac  ccu uca ggu caa cua  cgg uau cau uuu aag  aaa gag aau aaa        7827
Tyr  Pro Ser Gly Gln Leu  Arg Tyr His Phe Lys  Lys Glu Asn Lys            
2370                 2375                 2380                            

gua  auu gcu aaa uua gaa  aaa cau aua uca caa  caa aag aag aug        7872
Val  Ile Ala Lys Leu Glu  Lys His Ile Ser Gln  Gln Lys Lys Met            
2385                 2390                 2395                            

ugg  gca aaa ggu auu cgu  uac gaa ggu uua acu  aaa gau aau uua        7917
Trp  Ala Lys Gly Ile Arg  Tyr Glu Gly Leu Thr  Lys Asp Asn Leu            
2400                 2405                 2410                            

aaa  gcc gaa uua aga cca  uuu gaa aaa gug aga  auu gga aaa acg        7962
Lys  Ala Glu Leu Arg Pro  Phe Glu Lys Val Arg  Ile Gly Lys Thr            
2415                 2420                 2425                            

cgu  gua uuu gaa agu uuu  gac uuc uuu aca acc  uuu aac cau aga        8007
Arg  Val Phe Glu Ser Phe  Asp Phe Phe Thr Thr  Phe Asn His Arg            
2430                 2435                 2440                            

caa  cua uuu gga acg aua  caa gcu gca aug aag  aag cag aga gcu        8052
Gln  Leu Phe Gly Thr Ile  Gln Ala Ala Met Lys  Lys Gln Arg Ala            
2445                 2450                 2455                            

cgg  gga aca ugu caa auu  gga uua gcu caa uau  gau uuu acg cac        8097
Arg  Gly Thr Cys Gln Ile  Gly Leu Ala Gln Tyr  Asp Phe Thr His            
2460                 2465                 2470                            

uug  uau aau aga uug cug  cag acc ucu cca uuu  gcu guu cac ggg        8142
Leu  Tyr Asn Arg Leu Leu  Gln Thr Ser Pro Phe  Ala Val His Gly            
2475                 2480                 2485                            

gac  uuc gag gcc ugg gau  aag cau aug gau ugg  uuu uca gua cag        8187
Asp  Phe Glu Ala Trp Asp  Lys His Met Asp Trp  Phe Ser Val Gln            
2490                 2495                 2500                            

uug  gcu ugu aag aug ugg  acg aag guu uua ugg  aaa uca cca caa        8232
Leu  Ala Cys Lys Met Trp  Thr Lys Val Leu Trp  Lys Ser Pro Gln            
2505                 2510                 2515                            

uuc  caa cau ugg aau gau  aaa aua aau gca cac  aaa uuu gaa ugu        8277
Phe  Gln His Trp Asn Asp  Lys Ile Asn Ala His  Lys Phe Glu Cys            
2520                 2525                 2530                            

gaa  gaa aau uua uac cug  aug uug gaa acu gca  aug uuu ucu aau        8322
Glu  Glu Asn Leu Tyr Leu  Met Leu Glu Thr Ala  Met Phe Ser Asn            
2535                 2540                 2545                            

gug  uau gcu guu acu uug  gca gau gga cau aua  aua guu aaa gaa        8367
Val  Tyr Ala Val Thr Leu  Ala Asp Gly His Ile  Ile Val Lys Glu            
2550                 2555                 2560                            

aga  ucu caa ugu uca gga  gua gua gaa acg aca  acu uua aau ucu        8412
Arg  Ser Gln Cys Ser Gly  Val Val Glu Thr Thr  Thr Leu Asn Ser            
2565                 2570                 2575                            

acu  guu aau gac auu aag  ugu gug gcu guu aua  uug uau cug aua        8457
Thr  Val Asn Asp Ile Lys  Cys Val Ala Val Ile  Leu Tyr Leu Ile            
2580                 2585                 2590                            

aag  aaa cau aac gug gug  cuu aga acu cua ggu  gcu ucg gaa gca        8502
Lys  Lys His Asn Val Val  Leu Arg Thr Leu Gly  Ala Ser Glu Ala            
2595                 2600                 2605                            

gau  gca agg aag uac uau  gaa gau uac uug gaa  aca uug gag cuu        8547
Asp  Ala Arg Lys Tyr Tyr  Glu Asp Tyr Leu Glu  Thr Leu Glu Leu            
2610                 2615                 2620                            

uca  aag aag agu aga aaa  gcu uua uua aca ucg  aaa cau auu uau        8592
Ser  Lys Lys Ser Arg Lys  Ala Leu Leu Thr Ser  Lys His Ile Tyr            
2625                 2630                 2635                            

uca  ccg auu aua cca gau  aga aga acg auu aaa  caa aac uuu gau        8637
Ser  Pro Ile Ile Pro Asp  Arg Arg Thr Ile Lys  Gln Asn Phe Asp            
2640                 2645                 2650                            

aug  aua uau uau ggc gau  gau auu ggu auu gua  gua aau uua gaa        8682
Met  Ile Tyr Tyr Gly Asp  Asp Ile Gly Ile Val  Val Asn Leu Glu            
2655                 2660                 2665                            

uuu  cug uuu auu gua aau  uuu guu uca auu aaa  aau gcu uau aaa        8727
Phe  Leu Phe Ile Val Asn  Phe Val Ser Ile Lys  Asn Ala Tyr Lys            
2670                 2675                 2680                            

uac  uug uuc ggu auu aau  uug gac uca ccu cau  aaa gau ggg uca        8772
Tyr  Leu Phe Gly Ile Asn  Leu Asp Ser Pro His  Lys Asp Gly Ser            
2685                 2690                 2695                            

uua  gua ccu uuu gug ccu  uua aau gaa uug gaa  uuu guu agu aga        8817
Leu  Val Pro Phe Val Pro  Leu Asn Glu Leu Glu  Phe Val Ser Arg            
2700                 2705                 2710                            

acu  uuu gau uau cau ucu  gau acu aga acc guu  uau ccu aaa uua        8862
Thr  Phe Asp Tyr His Ser  Asp Thr Arg Thr Val  Tyr Pro Lys Leu            
2715                 2720                 2725                            

aaa  gaa caa uca auu ugg  aga cuu uug uuc ugg  ugu acu aau uua        8907
Lys  Glu Gln Ser Ile Trp  Arg Leu Leu Phe Trp  Cys Thr Asn Leu            
2730                 2735                 2740                            

cgu  cca gag cag aua gaa  ucc aau aug auu gca  aug gcu aac gaa        8952
Arg  Pro Glu Gln Ile Glu  Ser Asn Met Ile Ala  Met Ala Asn Glu            
2745                 2750                 2755                            

uug  uuc cuu uau gaa gaa  agu aaa uac aga uug  uuu agu uca auu        8997
Leu  Phe Leu Tyr Glu Glu  Ser Lys Tyr Arg Leu  Phe Ser Ser Ile            
2760                 2765                 2770                            

guc  aac gca aua aua uca  cca uau cug aaa cgc  caa uau aau ugg        9042
Val  Asn Ala Ile Ile Ser  Pro Tyr Leu Lys Arg  Gln Tyr Asn Trp            
2775                 2780                 2785                            

aau  uug aua uua cca agu  uau aga cuu gga agg  gua gca uuu gag        9087
Asn  Leu Ile Leu Pro Ser  Tyr Arg Leu Gly Arg  Val Ala Phe Glu            
2790                 2795                 2800                            

gag  aug ucg cau gaa cug  aag gag gug ccu cac  ucc agc acc ugu        9132
Glu  Met Ser His Glu Leu  Lys Glu Val Pro His  Ser Ser Thr Cys            
2805                 2810                 2815                            

uuu  acu gaa uug gag auu  cau uca auu uua cag  aaa gcg caa aau        9177
Phe  Thr Glu Leu Glu Ile  His Ser Ile Leu Gln  Lys Ala Gln Asn            
2820                 2825                 2830                            

aua  gga agc aac uga cuaaggacac uuccucuuuu guaauccgua aagaucgaac      9232
Ile  Gly Ser Asn                                                          
2835                                                                      

aaccuaggca uaaucaaggu accccggagc gacggugaag gacgggucca guaguucgcu     9292

acuguugagu agagugugag cuccgucgca ccggaacaag gcacguagga gacggucggg     9352

uccagauauu cguaucuguc gaguagagug ugggcuccua cgugcuuauu ggacaugcgg     9412

agacggucgg guccagauau ucguaucugu cgaguagagu gugggcuccg cauguccuua     9472

uugggugcau ggagacgguc ggguccagau auucguaucu gucgaguaga gugugggcuc     9532

caugcacccu uauugacgcc aacugaauga aauggugaag gacgggucca gguguggcug     9592

cuucggcagu gcagcuuguu gaguagagug ugagcuccgu aacuagucgc gucuuauugg     9652

uaaccuauuu ggggaccuca cuuuuaguug cuagcuaaca augggggccu uaaaauuauc     9712

uuauuaccuu aauugguugu aagugcugaa uuuuaagggg gccgcgcaua uugcguagua     9772

agaccugggc cuugcaugua gcauuauaag ucccacucgu uauagcuuaa aucguaccuu     9832

agcccguacg agacaagaag ugaauuauau uuaaccacca uauauuaauc auuuaguaua     9892

uaagguagau auuagaaauu aaauaauaua gaaaugauga auaaccuauc agcuugguaa     9952

uugccuaaau gcgucuguuu ucugugucaa uuuuagcgua agcuggccuu gacacuuuua    10012

accggugcau gaauagauua uuuuuaaaau uuguauuuuu acguaaguuu gccuacaaaa    10072

uuuuacauuu cgaaacaauc augaauagaa uaacaguaaa agugcguuag ucacguggcg    10132

caccuauauu aacuuuuuua acguuuauuu cauuaguaua gguuauucau uauaauauau    10192

uguacauaua cuauaauucc caaauuuaug uuuguuauug uacacccccg auuagucggu    10252

uuauauuuau auauuuggcu cugcgaaugc aguuaaacgc uaccacuuuu cggggacuau    10312

cuaaucuuua uauaaaauua guuagucgga uuuuagggcc uucagcccuc uaaucuuuuu    10372

auugaaaaaa aaaaaaaaaa aaaa                                           10396


<210>  95
<211>  2838
<212>  PRT
<213>  synthetic construct

<400>  95

Met Glu Ser Ser Asn Lys Asn Met Cys Thr Gly Phe Pro Gln Thr Leu 
1               5                   10                  15      


Lys Ile Ser Thr Glu Ile Ser Ile Ile Asn Gln Ser Ser Gln Thr Pro 
            20                  25                  30          


Arg Asp Trp Ser Tyr Val Gln Glu Asn Met Gln Gln Phe Lys Asn Tyr 
        35                  40                  45              


Leu Gln Leu Ala Trp Ile Glu Val Pro Asn Asn Ile Thr Ile Gly Asn 
    50                  55                  60                  


Phe Asp Val Phe Glu Asp Asn Met Pro Ile Ala His Ala Ile Ser Ser 
65                  70                  75                  80  


Asp Leu His Gln Thr Ala Gly Ile Ala Gly Val Leu Arg Gln Asn Tyr 
                85                  90                  95      


Phe Lys Asn Leu Pro Lys Val Asn Val Asn Lys Ser Asn Ile Gly Thr 
            100                 105                 110         


Leu Tyr Leu Tyr Pro Asn Lys Asn Leu Thr Arg Gln Ile Ile Gly Leu 
        115                 120                 125             


Ile Thr Lys Asp Ile Tyr Tyr Leu Lys Pro Thr Tyr Ala Ser Leu Phe 
    130                 135                 140                 


Thr Thr Leu Ile Glu Leu Arg Lys Tyr Leu Ile Asn Asn Lys Ile Lys 
145                 150                 155                 160 


Asn Ile Cys Leu Pro Met Val Gly Cys Asn Lys Asp Lys Leu Asn Pro 
                165                 170                 175     


Leu Ala Val Leu Pro Met Leu Met Tyr Cys Leu Gly Asn Ile Glu Thr 
            180                 185                 190         


Gln Val Lys Ile Thr Asn Lys Gly Val Tyr Phe Asn Tyr Gln Pro Ile 
        195                 200                 205             


Pro Val Ala Pro Lys Ile Asn Lys Ile Lys Phe Ser Lys Gln Met Glu 
    210                 215                 220                 


Lys Val Asn Tyr Asp Gln Thr Val Asp Thr Phe Glu Thr Asn Tyr Val 
225                 230                 235                 240 


Lys Pro Lys Lys Phe Lys Ala Lys Val Thr Phe Glu Pro Ser Leu Leu 
                245                 250                 255     


Asn Leu Asp Ser Asn Ser Ile Ile Ile Asn Glu Ser Lys Thr Val Lys 
            260                 265                 270         


Gln Ile Tyr Lys Ala Lys Leu Glu Lys Val Ile Tyr Gln Arg Ser Thr 
        275                 280                 285             


Val Tyr Glu Pro Gln Lys Lys Thr Tyr Val Val Glu Ala Phe Ser Cys 
    290                 295                 300                 


Lys Gln Pro Lys Pro Ile Val Lys Ile Phe Lys Met Lys Gln Ala Ile 
305                 310                 315                 320 


Leu Thr Gln Thr Asp Leu Lys Glu Asn Asn Asn Glu Leu Ile Lys Glu 
                325                 330                 335     


Arg Asn Ser Ile Asp Tyr Tyr Lys Phe Val Thr Pro Asn Thr Val Lys 
            340                 345                 350         


Ala Ile Ile Gly Tyr Asp Lys Val Glu Ser Val Leu Thr Phe Asp Leu 
        355                 360                 365             


Asp Arg Lys Arg Arg Cys Gly Glu Lys Ala Phe Val His Gly Lys Ser 
    370                 375                 380                 


Leu Lys Ser Ile Ala Lys Arg Gln Leu Cys Tyr Ser Tyr Val Pro Ser 
385                 390                 395                 400 


Leu Asn Ser Val Gln Val Tyr Ile Lys Met Leu Gln Leu Thr Ala Gln 
                405                 410                 415     


Lys Gln Val Phe Gly His Val Val Thr Lys Ile Gln Glu Ser Ile Ala 
            420                 425                 430         


Asn Met Asp Val His Gly Met Gln Ile Asn Asn Ile Pro Glu Glu Leu 
        435                 440                 445             


Met Lys Ser Leu Ser Arg Thr Ile Leu Glu Gln Leu Gln Leu Asp Thr 
    450                 455                 460                 


Lys Val Ile Lys Pro Val Leu Leu Ala Asn Ile Leu Asn Cys Phe Val 
465                 470                 475                 480 


Asn Val Val Cys Ala Leu Ile Ile Ile Phe Thr Ala Lys Ser Lys Val 
                485                 490                 495     


Ala Ser Gly Ala Ala Ile Val Gln Ile Ile Ser Asn Ile Leu Thr Leu 
            500                 505                 510         


Met Leu Asp Ile Gly Ile Tyr Tyr Ser Leu Lys His Met Thr Glu Glu 
        515                 520                 525             


Arg Ile Lys Ala Ile Thr Thr Thr Ile Thr Gln Asp Ala Val Gln Lys 
    530                 535                 540                 


Val Met Lys Gln His Gly Val Thr Met Met Ala Ser Asp Lys Val Ile 
545                 550                 555                 560 


Thr Ala Met Gln Asn Val Asp Leu Asn Asp Ala Lys Ser Ile Lys His 
                565                 570                 575     


Phe Ile Lys Glu Phe Glu Lys Glu Glu Asp Thr Asp Ile Ser Glu Ile 
            580                 585                 590         


Ser Pro Asp Cys Val Pro Asn Tyr Ser Asp Met Leu Pro Ile Gly Leu 
        595                 600                 605             


Gln Met Lys Lys Lys Asn Arg Leu Asp Met Asp Phe Val Leu Met Asp 
    610                 615                 620                 


Lys Ile Ala Val Val Asp Pro Thr Gly Lys Leu Met Lys Ile Val Ser 
625                 630                 635                 640 


Asp Cys Pro Tyr Asp Thr Pro Ser Lys Asn Asn Gln Cys Leu Leu His 
                645                 650                 655     


Ser Leu Leu Gly Ala Leu Asp His Arg Asp Arg Lys Val Leu Val Asp 
            660                 665                 670         


Glu Ser Asn Ile Glu Lys Phe Phe Gln Trp Met Ser Asp Asn Ile Ser 
        675                 680                 685             


Asp Pro Asp Val Ile Glu Ala Ile Asn Val Tyr Lys Met Glu Tyr Ala 
    690                 695                 700                 


Ser Asp Phe Pro Pro Glu Ala Thr Asn Leu Asp Val Leu Gln Gly Ile 
705                 710                 715                 720 


Lys Thr His Lys Lys Met Leu Pro Val Asp Leu Cys Lys Leu Leu Ser 
                725                 730                 735     


Lys Tyr Leu Asp Arg Thr Ile Ile Val Lys His Val Asn Lys Val Leu 
            740                 745                 750         


Thr Tyr Gly Pro Glu Arg Trp Asp Asn Asn Ile Pro Lys Ile Leu Gln 
        755                 760                 765             


Leu Glu Asn Gln His Phe Ser Tyr Ile Asp Arg Val Leu Val Asp Asn 
    770                 775                 780                 


Ile Leu Pro Leu Lys Ala Ala Val Glu Cys Met Val Gln Phe Thr Leu 
785                 790                 795                 800 


Thr Arg Ala Ala Gln Phe Asn Thr Pro Asp Thr Leu Lys Gln Lys Glu 
                805                 810                 815     


Tyr Tyr Leu Ala Met Ala Ala Ala Tyr Val Phe Thr Tyr Asn Ser Arg 
            820                 825                 830         


Ile Ala Val Cys Cys Met Asn Val Lys Ser Asn Lys Leu Asp Ala Lys 
        835                 840                 845             


Ser Ile Ile Gly Ile Cys Thr Asp Ile Leu Ser Thr Ile Ala Phe Val 
    850                 855                 860                 


Val Gly Met Gly Val Ser Ser Gly Asp Phe Ala Ser Arg Met Val Lys 
865                 870                 875                 880 


Ala Glu Lys Phe Ser Thr Ser Met Asp Thr Phe Ala Ser Arg Thr Thr 
                885                 890                 895     


Asn Lys Leu Asp Ser Ile Leu Ser Lys Ala Phe Gly Ile Tyr Met Ser 
            900                 905                 910         


Glu Asp Gly Glu Thr Val Ala Ser Leu Ser Lys Asp Ile Asp Ile Leu 
        915                 920                 925             


Glu Lys Tyr Lys Ala His Thr Val Ala Asp Tyr Met Asn Asn Met Ser 
    930                 935                 940                 


Lys Tyr Gln Glu Val Lys Thr Tyr Val Glu Gly Val Thr Lys Arg Met 
945                 950                 955                 960 


Thr Ser Leu His Leu Leu Asn Arg Asp Thr Thr Asn Ala Ile Gln Asn 
                965                 970                 975     


Thr Gln Asn Ile Ile Arg Lys Ser Cys Asp Ala Ile Met Ala Val Leu 
            980                 985                 990         


Asn Asp Val Asp Lys Leu Asn Arg  Met Glu Ser Leu Arg  Gln Glu Phe 
        995                 1000                 1005             


Val Gly  Leu Lys Gly Ala Gly  Lys Thr Ser Thr Leu  Asn Asn Tyr 
    1010                 1015                 1020             


Leu Ile  Pro Asn Ile Ala Lys  Arg Leu Ala Leu Asn  Pro Ser Thr 
    1025                 1030                 1035             


Tyr Ala  Ala Glu Ile Asp Ala  Asn Gly His Trp Lys  Pro Tyr Arg 
    1040                 1045                 1050             


Tyr Glu  Asp Phe Ala Leu Ile  Asp Asp Leu Phe Asn  Gln Gly Ser 
    1055                 1060                 1065             


Asn Asp  Pro Phe Ile Pro His  Ile Val Arg Met Ala  Ser Ser Leu 
    1070                 1075                 1080             


Asn Phe  Asp Leu Pro Gly Ala  Asp Leu Ser Asn Lys  Glu Lys Thr 
    1085                 1090                 1095             


Leu Arg  Ala Arg Phe Leu Phe  Ala Thr Ala Asn Val  Ala Tyr Val 
    1100                 1105                 1110             


Arg Met  Lys Glu Glu Met Pro  Ala Ser Ala Gln Glu  Gly Phe Tyr 
    1115                 1120                 1125             


Gly Arg  Phe Lys Cys Ile Gln  Phe Ile Asn Ala Lys  Gln Gly Ile 
    1130                 1135                 1140             


Asn Gln  Ala Arg Asp Ser Val  Glu Tyr Ile Asp Tyr  Glu Asp His 
    1145                 1150                 1155             


Asp Thr  Tyr Glu Leu Arg Met  Tyr Glu Glu Gln Ile  Asn Glu Gln 
    1160                 1165                 1170             


Phe Ser  Gln Ile Glu Arg Asn  Asp His Ile Thr Gly  Glu Arg Ile 
    1175                 1180                 1185             


Gln His  Phe Asp Pro Ser Thr  Lys Thr Tyr Asp Asp  His Ile Tyr 
    1190                 1195                 1200             


Lys Ile  Gly His Leu His Tyr  Lys Ile Val Thr Phe  Lys Gln Leu 
    1205                 1210                 1215             


Glu Thr  Ile Cys Ile Asp Gln  Phe Asn Lys Lys Tyr  Gln His Tyr 
    1220                 1225                 1230             


Lys Met  Ala Arg Asp Arg Lys  Cys Val Val Asp Phe  Glu Tyr Phe 
    1235                 1240                 1245             


Arg Asn  Ile Asp Met Lys Ser  Asp Ala Ile Val Glu  Asn Met Val 
    1250                 1255                 1260             


Arg Lys  Gly Tyr Leu Pro Ala  Glu Ile Glu Ala Ala  Arg Gln Thr 
    1265                 1270                 1275             


Val Gly  Leu Thr Ala Gly Pro  Asp Glu Val His Ala  Lys Ser Glu 
    1280                 1285                 1290             


Ser Ile  Ile Asn His Tyr Val  Val Ser Val Phe Gly  Asp Thr Gly 
    1295                 1300                 1305             


Thr Gly  Lys Ser Val Phe Ala  Thr Gln Leu Ala Leu  Asp Leu Ser 
    1310                 1315                 1320             


Asp Phe  Leu Asn Leu Lys Val  Tyr Ser Val Glu Asp  Ile Asn Asp 
    1325                 1330                 1335             


Thr Ala  His Leu Asp Tyr Leu  Asn Pro Ser Ile Ile  Val Phe His 
    1340                 1345                 1350             


Asp Ser  Ile Tyr Asp Glu Leu  Lys Tyr Val Ala Leu  Tyr Asp Lys 
    1355                 1360                 1365             


Leu Pro  Lys Pro Cys Leu Ile  Ile Thr Thr Ser Asn  His Thr Leu 
    1370                 1375                 1380             


Lys Trp  His Arg Glu Lys Leu  Cys Asn Ile Val Asp  Asn Ser Thr 
    1385                 1390                 1395             


Ser Ala  Ala Glu Arg Ser Ser  Ser Ala Leu Leu Glu  His Gly Phe 
    1400                 1405                 1410             


Phe Asn  Lys Met Lys Asn Lys  Ile Gly Gly Leu Val  Ser Tyr Phe 
    1415                 1420                 1425             


Asn Leu  Ser Ser Ile Arg Glu  Gly Tyr Leu Val Gln  Thr Phe Pro 
    1430                 1435                 1440             


Gly Tyr  Gln Pro Thr Pro Gly  Tyr Cys Arg Arg Leu  Gly Leu Asn 
    1445                 1450                 1455             


Thr Ala  Phe His Pro Ile Ser  Thr Glu Asp Leu Thr  Ser Asn Leu 
    1460                 1465                 1470             


Val Tyr  Ser Gln Arg Pro Asn  Lys Glu Thr Thr Thr  Ile Phe Ala 
    1475                 1480                 1485             


Thr Ser  Gly Tyr His Phe His  Gln Asp Asn Lys Glu  Val Gln Leu 
    1490                 1495                 1500             


Asn Glu  Val Val Lys Glu Val  Leu Met Lys Tyr Arg  Gly Ala Lys 
    1505                 1510                 1515             


Lys Phe  Ile Gln Pro Asp Ile  Ile Lys Leu Gly Val  Ser Glu Phe 
    1520                 1525                 1530             


Glu Glu  Gln Phe Lys Lys Leu  Thr Thr Ile Asp Val  Glu Ile Gln 
    1535                 1540                 1545             


Ser Lys  Asn Ile Glu Ser Leu  Ile Lys Leu Thr Asn  Asp Arg Ala 
    1550                 1555                 1560             


Ile Leu  Val Asn Ser Val Thr  Ala Ala Arg Phe Val  Gly Gly Ser 
    1565                 1570                 1575             


Asn Ile  Val Lys Val Ser Ser  Arg Val Arg Ser Asn  Asn Tyr Ser 
    1580                 1585                 1590             


Phe Asn  Pro Leu Asp Phe Ala  Ile Pro Ile Asn Ala  Thr Val Ser 
    1595                 1600                 1605             


Asp Ala  Leu Asp Ile Ala Met  Lys Ser Tyr Arg Leu  Leu Leu Ser 
    1610                 1615                 1620             


Ala Asn  Val Asp Tyr Thr Val  Phe Ile Lys Cys Glu  Glu Phe Ser 
    1625                 1630                 1635             


Cys Ile  Gly Ile Asn Gly Asn  Ile Tyr Tyr Thr Ser  Val Pro Phe 
    1640                 1645                 1650             


Asn Val  Thr Ser Tyr Ser His  Ile Ala Thr Lys Val  Ile Thr Phe 
    1655                 1660                 1665             


Tyr Lys  Val Asp Thr Asn Ser  Asp Gly Ile Thr Asn  Asn Ser Glu 
    1670                 1675                 1680             


Leu Ile  Lys Phe Thr Pro Asp  Glu Tyr Ala Lys Leu  Ile Ile Thr 
    1685                 1690                 1695             


Gly Glu  Gly Glu Gln Lys Leu  Phe Asp Lys Leu Pro  Tyr Ala Ala 
    1700                 1705                 1710             


Cys Lys  Tyr Ile Tyr Gly Ala  Arg Ala Glu Ile Glu  Pro His Phe 
    1715                 1720                 1725             


Ala Thr  Thr Phe Thr Lys Tyr  Glu Val Arg Thr Glu  Val Tyr Asp 
    1730                 1735                 1740             


Asn His  Thr Arg Glu Lys Met  Ala Phe Phe Val Ile  Tyr Ser Glu 
    1745                 1750                 1755             


Phe Lys  Lys Thr Ile Trp Tyr  Lys Ile Ala Ile Gly  Ile Leu Ala 
    1760                 1765                 1770             


Ile Thr  Ala Ser Val Leu Ile  Ile Glu Leu Ile Thr  Gln Ile Trp 
    1775                 1780                 1785             


Asn Met  Phe Ile Gly Leu Lys  Glu Val Phe Thr Ser  Thr Val Gln 
    1790                 1795                 1800             


Lys Asp  Asn Val Lys Val Val  Tyr Gln Val Leu Ser  Val Asn Pro 
    1805                 1810                 1815             


Lys Glu  Gln Ser Ala Glu Val  Lys Val Tyr Gly Phe  Lys Asp Asp 
    1820                 1825                 1830             


Leu Asp  Ser Phe Ser Asn Lys  Glu Leu Ser Asn Leu  Ile Ile Asp 
    1835                 1840                 1845             


Asp Ile  Asp Val Ala Lys Leu  Asp Asp Ser Ile Pro  Ala Asp Thr 
    1850                 1855                 1860             


Val Ile  Lys Ala Leu Asp Met  Ser Gln Met Thr Val  His Ser Asp 
    1865                 1870                 1875             


Trp Asn  Lys Lys Asp Phe Ala  Lys Asn Lys Val Pro  Thr Leu Val 
    1880                 1885                 1890             


His Arg  Met Leu Asp Met Arg  Val His Ser Asp Lys  Ser Gln Asp 
    1895                 1900                 1905             


Asn Lys  Lys Ile Ser Arg Lys  Ala Asn Arg Val Glu  Arg Ile Leu 
    1910                 1915                 1920             


Glu Asn  Met Thr Val Lys Gly  Glu Phe Asp Phe Ile  Lys His Lys 
    1925                 1930                 1935             


Ile Thr  Asn Ser Leu Gly Lys  Val Val Val Ser Ala  Ser Gly Val 
    1940                 1945                 1950             


Val Lys  Thr Val Val Gly Met  Asn Ile Lys Gly His  Tyr Val Ile 
    1955                 1960                 1965             


Cys Pro  Ala His Val Tyr Pro  Val Asp Thr Ala Phe  His Tyr Ala 
    1970                 1975                 1980             


Asn Phe  Thr Pro Phe Asn Thr  Gly Lys Asn Tyr Thr  Met Val Pro 
    1985                 1990                 1995             


Met Val  Cys Ser Arg Val Asp  Asp Leu Ala Leu Phe  Tyr Ile Thr 
    2000                 2005                 2010             


Asp Lys  Leu His Pro Leu Ala  Lys Asp Ile Thr His  His Phe Asp 
    2015                 2020                 2025             


Asp Gln  Glu Arg Leu Tyr Thr  Arg Pro Phe Glu Leu  Pro Tyr Met 
    2030                 2035                 2040             


His Leu  Arg Thr Gly Asn Val  Val Ser Trp Lys Gly  Gly Asp Ala 
    2045                 2050                 2055             


Ile Gly  Leu Arg Ser Leu Val  Thr Lys Val His Gln  Asp Met Leu 
    2060                 2065                 2070             


Leu Thr  Glu Gly Lys Pro Met  Val Ala Gly Gln Phe  Trp Ser Thr 
    2075                 2080                 2085             


Val Thr  Arg Leu Thr Lys Gly  Asp Cys Gly Phe Pro  Ile Ile Asp 
    2090                 2095                 2100             


Thr Asn  Ser His Lys Ile Phe  Ser Ile Tyr Cys Gly  Asp Asn Asn 
    2105                 2110                 2115             


Gly Val  Asn Ala Ile Tyr Gly  Asn Met Val Thr Ser  Thr Leu Val 
    2120                 2125                 2130             


Lys Lys  Met Ile Asp Phe Ala  Glu Gly Val Ser Glu  Val His Ala 
    2135                 2140                 2145             


Phe Thr  Arg Tyr Ser Pro Pro  Met Glu Glu Phe Phe  Asp Ala Glu 
    2150                 2155                 2160             


Asp Thr  Gly Val Met Lys Phe  Ser Tyr Pro Ser Gly  Glu Gln His 
    2165                 2170                 2175             


Ile Val  Met Pro Val Glu Thr  Cys Asp Tyr Ile Ser  Lys Ala Tyr 
    2180                 2185                 2190             


Glu Thr  Glu Asn Tyr Tyr Pro  Cys Met Asp Gly Glu  Phe Thr Arg 
    2195                 2200                 2205             


Asn Ile  Ala Tyr Ser Ser Asp  Cys Gln Lys Asn Ala  Phe Met Lys 
    2210                 2215                 2220             


Pro Lys  Tyr Gln Arg Thr Pro  Phe Ala Glu Glu Ile  Leu Thr Gln 
    2225                 2230                 2235             


Tyr Pro  Gln Ile Lys Asp Asp  Cys Arg Asn Ala Ala  Thr Asp Pro 
    2240                 2245                 2250             


Arg Leu  Val Glu Asp Lys Ser  Lys Leu Val Asn Ser  Val Lys Gly 
    2255                 2260                 2265             


Asp Pro  Ser Ile Val Met Thr  Gln Leu Ala Lys Ile  Asn Asp Pro 
    2270                 2275                 2280             


Ile Asp  Ala Ala Gly Gly Leu  Met Gly Glu Lys Phe  Met Glu Glu 
    2285                 2290                 2295             


Ala Ala  Glu Met Leu Thr Glu  Glu Tyr Ile Asp Leu  Tyr Ser Gly 
    2300                 2305                 2310             


Phe Asp  His Arg Phe Leu Thr  Thr Glu Glu Thr Ile  Asn Gly Ile 
    2315                 2320                 2325             


Ala Ser  Pro Gln Ser Asp Leu  Gln Gly His Leu Glu  Ala Val Asn 
    2330                 2335                 2340             


Arg Asp  Ala Ser Ala Gly His  Trp Cys Met Leu Asn  Gly Tyr His 
    2345                 2350                 2355             


Lys Ile  Ser Asp Leu Leu Glu  Glu Gly Gly Ser Tyr  Pro Ser Gly 
    2360                 2365                 2370             


Gln Leu  Arg Tyr His Phe Lys  Lys Glu Asn Lys Val  Ile Ala Lys 
    2375                 2380                 2385             


Leu Glu  Lys His Ile Ser Gln  Gln Lys Lys Met Trp  Ala Lys Gly 
    2390                 2395                 2400             


Ile Arg  Tyr Glu Gly Leu Thr  Lys Asp Asn Leu Lys  Ala Glu Leu 
    2405                 2410                 2415             


Arg Pro  Phe Glu Lys Val Arg  Ile Gly Lys Thr Arg  Val Phe Glu 
    2420                 2425                 2430             


Ser Phe  Asp Phe Phe Thr Thr  Phe Asn His Arg Gln  Leu Phe Gly 
    2435                 2440                 2445             


Thr Ile  Gln Ala Ala Met Lys  Lys Gln Arg Ala Arg  Gly Thr Cys 
    2450                 2455                 2460             


Gln Ile  Gly Leu Ala Gln Tyr  Asp Phe Thr His Leu  Tyr Asn Arg 
    2465                 2470                 2475             


Leu Leu  Gln Thr Ser Pro Phe  Ala Val His Gly Asp  Phe Glu Ala 
    2480                 2485                 2490             


Trp Asp  Lys His Met Asp Trp  Phe Ser Val Gln Leu  Ala Cys Lys 
    2495                 2500                 2505             


Met Trp  Thr Lys Val Leu Trp  Lys Ser Pro Gln Phe  Gln His Trp 
    2510                 2515                 2520             


Asn Asp  Lys Ile Asn Ala His  Lys Phe Glu Cys Glu  Glu Asn Leu 
    2525                 2530                 2535             


Tyr Leu  Met Leu Glu Thr Ala  Met Phe Ser Asn Val  Tyr Ala Val 
    2540                 2545                 2550             


Thr Leu  Ala Asp Gly His Ile  Ile Val Lys Glu Arg  Ser Gln Cys 
    2555                 2560                 2565             


Ser Gly  Val Val Glu Thr Thr  Thr Leu Asn Ser Thr  Val Asn Asp 
    2570                 2575                 2580             


Ile Lys  Cys Val Ala Val Ile  Leu Tyr Leu Ile Lys  Lys His Asn 
    2585                 2590                 2595             


Val Val  Leu Arg Thr Leu Gly  Ala Ser Glu Ala Asp  Ala Arg Lys 
    2600                 2605                 2610             


Tyr Tyr  Glu Asp Tyr Leu Glu  Thr Leu Glu Leu Ser  Lys Lys Ser 
    2615                 2620                 2625             


Arg Lys  Ala Leu Leu Thr Ser  Lys His Ile Tyr Ser  Pro Ile Ile 
    2630                 2635                 2640             


Pro Asp  Arg Arg Thr Ile Lys  Gln Asn Phe Asp Met  Ile Tyr Tyr 
    2645                 2650                 2655             


Gly Asp  Asp Ile Gly Ile Val  Val Asn Leu Glu Phe  Leu Phe Ile 
    2660                 2665                 2670             


Val Asn  Phe Val Ser Ile Lys  Asn Ala Tyr Lys Tyr  Leu Phe Gly 
    2675                 2680                 2685             


Ile Asn  Leu Asp Ser Pro His  Lys Asp Gly Ser Leu  Val Pro Phe 
    2690                 2695                 2700             


Val Pro  Leu Asn Glu Leu Glu  Phe Val Ser Arg Thr  Phe Asp Tyr 
    2705                 2710                 2715             


His Ser  Asp Thr Arg Thr Val  Tyr Pro Lys Leu Lys  Glu Gln Ser 
    2720                 2725                 2730             


Ile Trp  Arg Leu Leu Phe Trp  Cys Thr Asn Leu Arg  Pro Glu Gln 
    2735                 2740                 2745             


Ile Glu  Ser Asn Met Ile Ala  Met Ala Asn Glu Leu  Phe Leu Tyr 
    2750                 2755                 2760             


Glu Glu  Ser Lys Tyr Arg Leu  Phe Ser Ser Ile Val  Asn Ala Ile 
    2765                 2770                 2775             


Ile Ser  Pro Tyr Leu Lys Arg  Gln Tyr Asn Trp Asn  Leu Ile Leu 
    2780                 2785                 2790             


Pro Ser  Tyr Arg Leu Gly Arg  Val Ala Phe Glu Glu  Met Ser His 
    2795                 2800                 2805             


Glu Leu  Lys Glu Val Pro His  Ser Ser Thr Cys Phe  Thr Glu Leu 
    2810                 2815                 2820             


Glu Ile  His Ser Ile Leu Gln  Lys Ala Gln Asn Ile  Gly Ser Asn 
    2825                 2830                 2835             


<210>  96
<211>  416
<212>  RNA
<213>  synthetic construct


<220>
<221>  misc_RNA
<222>  (1)..(416)
<223>  Contains an AvrII/KpnI MCS and 3 broccoli fluorescence aptamers.

<400>  96
ccuaggcaua aucaagguac cccggagcga cggugaagga cggguccagu aguucgcuac       60

uguugaguag agugugagcu ccgucgcucc gguuauuggc acguaggaga cggucggguc      120

cagauauucg uaucugucga guagagugug ggcuccuacg ugcuuauugg acaugcggag      180

acggucgggu ccagauauuc guaucugucg aguagagugu gggcuccgca uguccuuauu      240

gggugcaugg agacggucgg guccagauau ucguaucugu cgaguagagu gugggcucca      300

ugcacccuua uugacgccaa cugaaugaaa uggugaagga cggguccagg uguggcugcu      360

ucggcagugc agcuuguuga guagagugug agcuccguaa cuagucgcgu cuuauu          416


<210>  97
<211>  2245
<212>  RNA
<213>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(2245)
<223>  Central region

<220>
<221>  misc_feature
<222>  (25)..(129)
<223>  MV-RNA Mango I

<220>
<221>  misc_feature
<222>  (135)..(563)
<223>  (4) MV-RNA targeting WCR vATPase gene

<220>
<221>  misc_feature
<222>  (569)..(678)
<223>  MV-RNA Mango II

<220>
<221>  misc_feature
<222>  (684)..(1109)
<223>  (4) MV-RNA targeting WCR Sec23 gene

<220>
<221>  misc_feature
<222>  (1115)..(1218)
<223>  MV-RNA Mango III

<220>
<221>  misc_feature
<222>  (1224)..(1674)
<223>  (4) MV-RNA targeting WCR Snakeskin gene

<220>
<221>  misc_feature
<222>  (1680)..(1789)
<223>  MV-RNA Mango IV

<220>
<221>  misc_feature
<222>  (1795)..(2215)
<223>  (4) MV-RNA targeting WCR DVsnf7 gene

<400>  97
cuagggcaac gccggucuua uuauacgcca aacaagcuuu gccgaucuga gccugggagc       60

ucucggcaaa gcagcuugag aucgaaggag aggagaggaa gaggagagua ucucaagcau      120

guuuggcgua uuauaccagc acguucguag aagggaucug agccugggag cucucccuuc      180

uacgucuaac augcccucgu guagcucauu agcuccgagg gcauguuaga uguguuggua      240

uuauaaauuu cucucaaagc uucgggaucu gagccuggga gcucucccga agcuuaauug      300

acugcucgug uagcucauua gcuccgagca gucaauucag ggaaauuuau uaucuuacgu      360

ugggcaaguu ucgaucugag ccugggagcu cucgaaauuu gcgccgaagc uucucgugua      420

gcucauuagc uccgagaagc uucggcccaa cgugagauua ucuuguccaa accccagaac      480

gaucugagcc ugggagcucu cguucugggg cguaagcacu cucguguagc ucauuagcuc      540

cgagagugcu uacguugggc aagauuaucg gccacacgga uccugcgcuc guguagcuca      600

uuagcuccga gcgcaggaua auccgagaua ccgagggagu ggugaggaug aggcgaguau      660

cucggaugcg uguggccgau uauuuugcaa aauuucuugu gcagaucuga gccugggagc      720

ucucugcaua agagguuccc aacucgugua gcucauuagc uccgaguugg gaaccuaguu      780

ugcaaaauua uacuugaagg gauacaucau cgaucugagc cugggagcuc ucgaugaugu      840

accccuuggu cucguguagc ucauuagcuc cgagaccaag gggcucuuca cguauuauug      900

uguauucaau gguggaaaga ucugagccug ggagcucucu uuccaccaac gccaagucuc      960

guguagcuca uuagcuccga gacuuggcgu uaaaguacac aauuauccua guuugcaaaa     1020

uuucuugauc ugagccuggg agcucucaag aaauuuauau caagacucgu guagcucauu     1080

agcuccgagu cuugauauuu uaaacuacga uuauacgcca gccacuaguu gcggaucuga     1140

gccugggagc ucuccgcaac uaauagugag cucgaaggag aggagaggaa gaggagagag     1200

cucacuaaug gcuggcguau uauugcugaa guucuuugcu ucagaucuga gccugggagc     1260

ucucugaagc aaaggcugau caguuucucg uguagcucau uagcuccgag aaauugauca     1320

ccaacuucag caauuauugg aaucuaauua uauuuaugau cugagccugg gagcucucau     1380

aaauauaaua ugaagagaac ucguguagcu cauuagcucc gaguuuucuu cguuuagauu     1440

ccaauuauaa gccaaaaugg auucaauuga ucugagccug ggagcucucg auugaauccg     1500

guuaauagcu ucucguguag cucauuagcu ccgagaaguu auugcauuuu ggcuuauuau     1560

guuauauacu aaaugcaaua gaucugagcc ugggagcucu cuauugcauu uuggcuuuga     1620

gcacucgugu agcucauuag cuccgagugc uuaaaguaaa guauauaaca uuauauuauc     1680

ggccacgcuc uagaugcgcu cguguagcuc auuagcuccg agcgcaucua uuagagagag     1740

accgagggag uggugaggau gaggcgaguc ucucucuaaa gcguggccga uuauuccaug     1800

auaucgugaa caugaucuga gccugggagc ucucauguuc acgucaugga ugcucgugua     1860

gcucauuagc uccgagcauc caugauaucg ugaaauuaua ggggcuaucu cuuccuuuga     1920

ucugagccug ggagcucuca aaggaagaca caaauaccuc guguagcuca uuagcuccga     1980

gguauuugug cuagcuccua uuauaccaug guaaauucuu cuaugaucug agccugggag     2040

cucucauaga agaacaaaga aaacucgugu agcucauuag cuccgaguuu ucuuugcuac     2100

caugguauua uuguaguugg gucuuuucca ggaucugagc cugggagcuc uccuggaaaa     2160

gacuaaacca acucguguag cucauuagcu ccgaguuggu uuaguagcaa cugcaauuau     2220

gaccggcguu gccuuaggcc gguac                                           2245


<210>  98
<211>  1879
<212>  RNA
<213>  synthetic construct


<220>
<221>  5'UTR
<222>  (1)..(675)

<220>
<221>  misc_signal
<222>  (676)..(717)

<220>
<221>  misc_feature
<222>  (719)..(737)
<223>  AvrII/KpnI MCS site

<220>
<221>  misc_feature
<222>  (719)..(1128)
<223>  Central region

<220>
<221>  3'UTR
<222>  (1134)..(1879)

<400>  98
ccauuacggc cgggggaaaa uaagggcuau ggcgucaugc cauaguuuau auacaccacg       60

gauuacguga accuuguuag uaauaacggg ugcccuuugu uagggaugug uuuuaugaau      120

uauuaauuau guuauaacuc uuauuuucaa cuacgggauu aaaaccccac uuuaaaacua      180

uauagggaaa uuuaguuuaa accuguauag gaaauuaagg auugauaauu uuauugaacg      240

agccuacucg uugaauauuu auaguuaguu gugauaacua gccuuguauu uagacaugga      300

uaaucuccag cccauguucg acauaccuua ggaaguuuau augcggcacg uauucaauua      360

aaugaagaug cuauaagugc uugauuagac auuaaaacua gaacaaguuc ucuaguuguc      420

gcugguagag cauaacuuau aguaggugga uuuuauuuga ugacccaagu auuuaugaaa      480

uuugucggcc uccaaguuga ucagcuaauu auuuauauuu ugcgaguaau aguaguucag      540

acugugcuau ccccuugaca ugcauuuuuu gguuacucca gauugugaua uuagggcucu      600

aauauugcaa gacugcccac caaguaagga acuuauguaa acuugcuugg gaaacacauu      660

acucaaaaaa uuauucuaag gacacuuccu cuuuuguaau ccguaaagau cgaacaaccu      720

aggcauaauc aagguacccc ggagcgacgg ugaaggacgg guccaguagu ucgcuacugu      780

ugaguagagu gugagcuccg ucgcuccggu uauuggcacg uaggagacgg ucggguccag      840

auauucguau cugucgagua gagugugggc uccuacgugc uuauuggaca ugcggagacg      900

gucgggucca gauauucgua ucugucgagu agaguguggg cuccgcaugu ccuuauuggg      960

ugcauggaga cggucggguc cagauauucg uaucugucga guagagugug ggcuccaugc     1020

acccuuauug acgccaacug aaugaaaugg ugaaggacgg guccaggugu ggcugcuucg     1080

gcagugcagc uuguugagua gagugugagc uccguaacua gucgcgucuu auugguaacc     1140

uauuugggga ccucacuuuu aguugcuagc uaacaauggg ggccuuaaaa uuaucuuauu     1200

accuuaauug guuguaagug cugaauuuua agggggccgc gcauauugcg uaguaagacc     1260

ugggccuugc auguagcauu auaaguccca cucguuauag cuuaaaucgu accuuagccc     1320

guacgagaca agaagugaau uauauuuaac caccauauau uaaucauuua guauauaagg     1380

uagauauuag aaauuaaaua auauagaaau gaugaauaac cuaucagcuu gguaauugcc     1440

uaaaugcguc uguuuucugu gucaauuuua gcguaagcug gccuugacac uuuuaaccgg     1500

ugcaugaaua gauuauuuuu aaaauuugua uuuuuacgua aguuugccua caaaauuuua     1560

cauuucgaaa caaucaugaa uagaauaaca guaaaagugc guuagucacg uggcgcaccu     1620

auauuaacuu uuuuaacguu uauuucauua guauagguua uucauuauaa uauauuguac     1680

auauacuaua auucccaaau uuauguuugu uauuguacac ccccgauuag ucgguuuaua     1740

uuuauauauu uggcucugcg aaugcaguua aacgcuacca cuuuucgggg acuaucuaau     1800

cuuuauauaa aauuaguuag ucggauuuua gggccuucag cccucuaauc uuuuuauuga     1860

aaaaaaaaaa aaaaaaaaa                                                  1879


<210>  99
<211>  4105
<212>  RNA
<213>  synthetic construct


<220>
<221>  misc_feature
<222>  (719)..(2910)
<223>  WCR MV-RNA sequence group ligated into AvrII/KpnI sites of 
       DVVv3-min.

<400>  99
ccauuacggc cgggggaaaa uaagggcuau ggcgucaugc cauaguuuau auacaccacg       60

gauuacguga accuuguuag uaauaacggg ugcccuuugu uagggaugug uuuuaugaau      120

uauuaauuau guuauaacuc uuauuuucaa cuacgggauu aaaaccccac uuuaaaacua      180

uauagggaaa uuuaguuuaa accuguauag gaaauuaagg auugauaauu uuauugaacg      240

agccuacucg uugaauauuu auaguuaguu gugauaacua gccuuguauu uagacaugga      300

uaaucuccag cccauguucg acauaccuua ggaaguuuau augcggcacg uauucaauua      360

aaugaagaug cuauaagugc uugauuagac auuaaaacua gaacaaguuc ucuaguuguc      420

gcugguagag cauaacuuau aguaggugga uuuuauuuga ugacccaagu auuuaugaaa      480

uuugucggcc uccaaguuga ucagcuaauu auuuauauuu ugcgaguaau aguaguucag      540

acugugcuau ccccuugaca ugcauuuuuu gguuacucca gauugugaua uuagggcucu      600

aauauugcaa gacugcccac caaguaagga acuuauguaa acuugcuugg gaaacacauu      660

acucaaaaaa uuauucuaag gacacuuccu cuuuuguaau ccguaaagau cgaacaaccu      720

agggcaacgc cggucuuauu auacgccaaa caagcuuugc cgaucugagc cugggagcuc      780

ucggcaaagc agcuugagau cgaaggagag gagaggaaga ggagaguauc ucaagcaugu      840

uuggcguauu auaccagcac guucguagaa gggaucugag ccugggagcu cucccuucua      900

cgucuaacau gcccucgugu agcucauuag cuccgagggc auguuagaug uguugguauu      960

auaaauuucu cucaaagcuu cgggaucuga gccugggagc ucucccgaag cuuaauugac     1020

ugcucgugua gcucauuagc uccgagcagu caauucaggg aaauuuauua ucuuacguug     1080

ggcaaguuuc gaucugagcc ugggagcucu cgaaauuugc gccgaagcuu cucguguagc     1140

ucauuagcuc cgagaagcuu cggcccaacg ugagauuauc uuguccaaac cccagaacga     1200

ucugagccug ggagcucucg uucuggggcg uaagcacucu cguguagcuc auuagcuccg     1260

agagugcuua cguugggcaa gauuaucggc cacacggauc cugcgcucgu guagcucauu     1320

agcuccgagc gcaggauaau ccgagauacc gagggagugg ugaggaugag gcgaguaucu     1380

cggaugcgug uggccgauua uuuugcaaaa uuucuugugc agaucugagc cugggagcuc     1440

ucugcauaag agguucccaa cucguguagc ucauuagcuc cgaguuggga accuaguuug     1500

caaaauuaua cuugaaggga uacaucaucg aucugagccu gggagcucuc gaugauguac     1560

cccuuggucu cguguagcuc auuagcuccg agaccaaggg gcucuucacg uauuauugug     1620

uauucaaugg uggaaagauc ugagccuggg agcucucuuu ccaccaacgc caagucucgu     1680

guagcucauu agcuccgaga cuuggcguua aaguacacaa uuauccuagu uugcaaaauu     1740

ucuugaucug agccugggag cucucaagaa auuuauauca agacucgugu agcucauuag     1800

cuccgagucu ugauauuuua aacuacgauu auacgccagc cacuaguugc ggaucugagc     1860

cugggagcuc uccgcaacua auagugagcu cgaaggagag gagaggaaga ggagagagcu     1920

cacuaauggc uggcguauua uugcugaagu ucuuugcuuc agaucugagc cugggagcuc     1980

ucugaagcaa aggcugauca guuucucgug uagcucauua gcuccgagaa auugaucacc     2040

aacuucagca auuauuggaa ucuaauuaua uuuaugaucu gagccuggga gcucucauaa     2100

auauaauaug aagagaacuc guguagcuca uuagcuccga guuuucuucg uuuagauucc     2160

aauuauaagc caaaauggau ucaauugauc ugagccuggg agcucucgau ugaauccggu     2220

uaauagcuuc ucguguagcu cauuagcucc gagaaguuau ugcauuuugg cuuauuaugu     2280

uauauacuaa augcaauaga ucugagccug ggagcucucu auugcauuuu ggcuuugagc     2340

acucguguag cucauuagcu ccgagugcuu aaaguaaagu auauaacauu auauuaucgg     2400

ccacgcucua gaugcgcucg uguagcucau uagcuccgag cgcaucuauu agagagagac     2460

cgagggagug gugaggauga ggcgagucuc ucucuaaagc guggccgauu auuccaugau     2520

aucgugaaca ugaucugagc cugggagcuc ucauguucac gucauggaug cucguguagc     2580

ucauuagcuc cgagcaucca ugauaucgug aaauuauagg ggcuaucucu uccuuugauc     2640

ugagccuggg agcucucaaa ggaagacaca aauaccucgu guagcucauu agcuccgagg     2700

uauuugugcu agcuccuauu auaccauggu aaauucuucu augaucugag ccugggagcu     2760

cucauagaag aacaaagaaa acucguguag cucauuagcu ccgaguuuuc uuugcuacca     2820

ugguauuauu guaguugggu cuuuuccagg aucugagccu gggagcucuc cuggaaaaga     2880

cuaaaccaac ucguguagcu cauuagcucc gaguugguuu aguagcaacu gcaauuauga     2940

ccggcguugc cuuaggccgg uaccccggag cgacggugaa ggacgggucc aguaguucgc     3000

uacuguugag uagaguguga gcuccgucgc uccgguuauu ggcacguagg agacggucgg     3060

guccagauau ucguaucugu cgaguagagu gugggcuccu acgugcuuau uggacaugcg     3120

gagacggucg gguccagaua uucguaucug ucgaguagag ugugggcucc gcauguccuu     3180

auugggugca uggagacggu cggguccaga uauucguauc ugucgaguag agugugggcu     3240

ccaugcaccc uuauugacgc caacugaaug aaauggugaa ggacgggucc agguguggcu     3300

gcuucggcag ugcagcuugu ugaguagagu gugagcuccg uaacuagucg cgucuuauug     3360

guaaccuauu uggggaccuc acuuuuaguu gcuagcuaac aaugggggcc uuaaaauuau     3420

cuuauuaccu uaauugguug uaagugcuga auuuuaaggg ggccgcgcau auugcguagu     3480

aagaccuggg ccuugcaugu agcauuauaa gucccacucg uuauagcuua aaucguaccu     3540

uagcccguac gagacaagaa gugaauuaua uuuaaccacc auauauuaau cauuuaguau     3600

auaagguaga uauuagaaau uaaauaauau agaaaugaug aauaaccuau cagcuuggua     3660

auugccuaaa ugcgucuguu uucuguguca auuuuagcgu aagcuggccu ugacacuuuu     3720

aaccggugca ugaauagauu auuuuuaaaa uuuguauuuu uacguaaguu ugccuacaaa     3780

auuuuacauu ucgaaacaau caugaauaga auaacaguaa aagugcguua gucacguggc     3840

gcaccuauau uaacuuuuuu aacguuuauu ucauuaguau agguuauuca uuauaauaua     3900

uuguacauau acuauaauuc ccaaauuuau guuuguuauu guacaccccc gauuagucgg     3960

uuuauauuua uauauuuggc ucugcgaaug caguuaaacg cuaccacuuu ucggggacua     4020

ucuaaucuuu auauaaaauu aguuagucgg auuuuagggc cuucagcccu cuaaucuuuu     4080

uauugaaaaa aaaaaaaaaa aaaaa                                           4105


<210>  100
<211>  12622
<212>  RNA
<213>  synthetic construct


<220>
<221>  5'UTR
<222>  (1)..(675)

<220>
<221>  CDS
<222>  (676)..(9192)
<223>  ORF1 polyprotein

<220>
<221>  misc_feature
<222>  (7453)..(9066)
<223>  RdRp

<220>
<221>  misc_feature
<222>  (7453)..(9066)

<220>
<221>  misc_feature
<222>  (9193)..(11480)
<223>  Subvrial RNA. WCR MV-RNA group in place of subviral ORF2 
       structural protein.

<220>
<221>  promoter
<222>  (9193)..(9234)
<223>  Intergenic region IGR

<220>
<221>  3'UTR
<222>  (11877)..(12622)

<400>  100
ccauuacggc cgggggaaaa uaagggcuau ggcgucaugc cauaguuuau auacaccacg       60

gauuacguga accuuguuag uaauaacggg ugcccuuugu uagggaugug uuuuaugaau      120

uauuaauuau guuauaacuc uuauuuucaa cuacgggauu aaaaccccac uuuaaaacua      180

uauagggaaa uuuaguuuaa accuguauag gaaauuaagg auugauaauu uuauugaacg      240

agccuacucg uugaauauuu auaguuaguu gugauaacua gccuuguauu uagacaugga      300

uaaucuccag cccauguucg acauaccuua ggaaguuuau augcggcacg uauucaauua      360

aaugaagaug cuauaagugc uugauuagac auuaaaacua gaacaaguuc ucuaguuguc      420

gcugguagag cauaacuuau aguaggugga uuuuauuuga ugacccaagu auuuaugaaa      480

uuugucggcc uccaaguuga ucagcuaauu auuuauauuu ugcgaguaau aguaguucag      540

acugugcuau ccccuugaca ugcauuuuuu gguuacucca gauugugaua uuagggcucu      600

aauauugcaa gacugcccac caaguaagga acuuauguaa acuugcuugg gaaacacauu      660

acucaaaaaa uuauu aug gaa agu uca aau aag aau aug ugu acu gga uuc       711
                 Met Glu Ser Ser Asn Lys Asn Met Cys Thr Gly Phe          
                 1               5                   10                   

ccc caa acc cuu aaa auc uca acg gaa auu agu auc aua aac caa uca        759
Pro Gln Thr Leu Lys Ile Ser Thr Glu Ile Ser Ile Ile Asn Gln Ser           
        15                  20                  25                        

ucu caa acc ccc aga gau ugg ucu uau gua caa gaa aau aug caa cag        807
Ser Gln Thr Pro Arg Asp Trp Ser Tyr Val Gln Glu Asn Met Gln Gln           
    30                  35                  40                            

uuu aaa aau uau uua caa uua gca ugg auu gaa guu ccg aau aac auu        855
Phe Lys Asn Tyr Leu Gln Leu Ala Trp Ile Glu Val Pro Asn Asn Ile           
45                  50                  55                  60            

aca aua gga aau uuu gac guu uuu gaa gau aau aug cca auu gcu cac        903
Thr Ile Gly Asn Phe Asp Val Phe Glu Asp Asn Met Pro Ile Ala His           
                65                  70                  75                

gcu auu uca ucg gau uug cau caa aca gca ggu auu gcu ggu guu uua        951
Ala Ile Ser Ser Asp Leu His Gln Thr Ala Gly Ile Ala Gly Val Leu           
            80                  85                  90                    

aga caa aau uau uuu aaa aau cua ccu aaa guu aac gua aau aaa agu        999
Arg Gln Asn Tyr Phe Lys Asn Leu Pro Lys Val Asn Val Asn Lys Ser           
        95                  100                 105                       

aau auu gga acc uua uau uug uau cca aau aaa aau uua acu cga caa       1047
Asn Ile Gly Thr Leu Tyr Leu Tyr Pro Asn Lys Asn Leu Thr Arg Gln           
    110                 115                 120                           

auu auu gga uug auu acu aaa gau auu uau uau uua aaa cca acu uau       1095
Ile Ile Gly Leu Ile Thr Lys Asp Ile Tyr Tyr Leu Lys Pro Thr Tyr           
125                 130                 135                 140           

gcu uca cuu uuu aca acu uua auu gaa uug cgu aaa uau cuu auu aau       1143
Ala Ser Leu Phe Thr Thr Leu Ile Glu Leu Arg Lys Tyr Leu Ile Asn           
                145                 150                 155               

aau aaa aua aaa aau auu ugc cua ccu aug gua ggu ugu aau aaa gau       1191
Asn Lys Ile Lys Asn Ile Cys Leu Pro Met Val Gly Cys Asn Lys Asp           
            160                 165                 170                   

aaa uua aau ccu cuu gca guu uua ccc aug cua aug uau ugc cuc ggc       1239
Lys Leu Asn Pro Leu Ala Val Leu Pro Met Leu Met Tyr Cys Leu Gly           
        175                 180                 185                       

aau auu gaa acu caa gua aaa aua acu aau aaa gga guu uau uuu aau       1287
Asn Ile Glu Thr Gln Val Lys Ile Thr Asn Lys Gly Val Tyr Phe Asn           
    190                 195                 200                           

uau caa cca auu ccu guu gcu cca aaa auu aau aaa auu aaa uuu agu       1335
Tyr Gln Pro Ile Pro Val Ala Pro Lys Ile Asn Lys Ile Lys Phe Ser           
205                 210                 215                 220           

aaa caa aug gaa aaa guu aau uau gau caa acu gua gau acu uuu gaa       1383
Lys Gln Met Glu Lys Val Asn Tyr Asp Gln Thr Val Asp Thr Phe Glu           
                225                 230                 235               

aca aau uau guu aaa ccu aag aaa uuc aaa gcu aaa gua aca uuu gaa       1431
Thr Asn Tyr Val Lys Pro Lys Lys Phe Lys Ala Lys Val Thr Phe Glu           
            240                 245                 250                   

ccc ucu cuu uua aau cuu gau ucu aau agu auu aua auu aau gaa agu       1479
Pro Ser Leu Leu Asn Leu Asp Ser Asn Ser Ile Ile Ile Asn Glu Ser           
        255                 260                 265                       

aag aca gua aaa caa auu uau aaa gcu aaa uua gaa aaa gua aua uau       1527
Lys Thr Val Lys Gln Ile Tyr Lys Ala Lys Leu Glu Lys Val Ile Tyr           
    270                 275                 280                           

caa aga ucu aca guu uau gaa cca caa aag aag aca uau gug gua gaa       1575
Gln Arg Ser Thr Val Tyr Glu Pro Gln Lys Lys Thr Tyr Val Val Glu           
285                 290                 295                 300           

gcu uuu ucu ugu aaa caa ccu aaa cca auu guc aaa auu uuu aaa aug       1623
Ala Phe Ser Cys Lys Gln Pro Lys Pro Ile Val Lys Ile Phe Lys Met           
                305                 310                 315               

aaa caa gca auu uua acu caa acu gac uua aaa gaa aau aau aau gaa       1671
Lys Gln Ala Ile Leu Thr Gln Thr Asp Leu Lys Glu Asn Asn Asn Glu           
            320                 325                 330                   

cua auu aaa gaa aga aau agu auu gau uau uau aaa uuu guu aca ccu       1719
Leu Ile Lys Glu Arg Asn Ser Ile Asp Tyr Tyr Lys Phe Val Thr Pro           
        335                 340                 345                       

aac acc guu aaa gcu auu auc gga uac gac aaa gua gaa uca guu uug       1767
Asn Thr Val Lys Ala Ile Ile Gly Tyr Asp Lys Val Glu Ser Val Leu           
    350                 355                 360                           

aca uuu gau uug gau cgu aaa cgu aga ugu gga gaa aaa gcu uuu gua       1815
Thr Phe Asp Leu Asp Arg Lys Arg Arg Cys Gly Glu Lys Ala Phe Val           
365                 370                 375                 380           

cau gga aaa ucu uua aaa uca aua gcu aaa cga caa cug ugu uau agu       1863
His Gly Lys Ser Leu Lys Ser Ile Ala Lys Arg Gln Leu Cys Tyr Ser           
                385                 390                 395               

uau gua cca ucu cua aac uca gug caa gua uau auu aaa aug uua caa       1911
Tyr Val Pro Ser Leu Asn Ser Val Gln Val Tyr Ile Lys Met Leu Gln           
            400                 405                 410                   

uua acg gcg cag aaa caa gua uuu ggu cau gua gua acg aaa auu caa       1959
Leu Thr Ala Gln Lys Gln Val Phe Gly His Val Val Thr Lys Ile Gln           
        415                 420                 425                       

gaa agu auu gcc aau aug gau guu cau gga aug caa auu aac aau aua       2007
Glu Ser Ile Ala Asn Met Asp Val His Gly Met Gln Ile Asn Asn Ile           
    430                 435                 440                           

ccu gaa gaa uua aug aaa uca uua ucc aga aca auu uua gaa caa uua       2055
Pro Glu Glu Leu Met Lys Ser Leu Ser Arg Thr Ile Leu Glu Gln Leu           
445                 450                 455                 460           

caa uua gac acu aaa gua aua aaa cca guu uug uua gca aau aua uua       2103
Gln Leu Asp Thr Lys Val Ile Lys Pro Val Leu Leu Ala Asn Ile Leu           
                465                 470                 475               

aau ugu uuc gua aau guu guu ugu gcc uua aua aua aua uuc acu gcc       2151
Asn Cys Phe Val Asn Val Val Cys Ala Leu Ile Ile Ile Phe Thr Ala           
            480                 485                 490                   

aaa agu aaa guu gca ucu gga gca gcu auu guu caa aua auu uca aau       2199
Lys Ser Lys Val Ala Ser Gly Ala Ala Ile Val Gln Ile Ile Ser Asn           
        495                 500                 505                       

auu uua acc uua aug uug gau aua ggc auu uau uau uca cuu aaa cau       2247
Ile Leu Thr Leu Met Leu Asp Ile Gly Ile Tyr Tyr Ser Leu Lys His           
    510                 515                 520                           

aug acc gaa gaa aga auu aaa gca aua acu acg acu aua aca cag gau       2295
Met Thr Glu Glu Arg Ile Lys Ala Ile Thr Thr Thr Ile Thr Gln Asp           
525                 530                 535                 540           

gcu guc caa aaa gua aug aaa caa cau ggc gua acu aug aug gca ucu       2343
Ala Val Gln Lys Val Met Lys Gln His Gly Val Thr Met Met Ala Ser           
                545                 550                 555               

gau aaa gua aua aca gcc aug caa aau guc gau uua aau gau gcu aaa       2391
Asp Lys Val Ile Thr Ala Met Gln Asn Val Asp Leu Asn Asp Ala Lys           
            560                 565                 570                   

uca aua aag cau uuu aua aaa gaa uuc gaa aaa gaa gaa gau acc gac       2439
Ser Ile Lys His Phe Ile Lys Glu Phe Glu Lys Glu Glu Asp Thr Asp           
        575                 580                 585                       

auu uca gaa auu uca ccc gau ugu gua cca aac uau ucu gau aug uua       2487
Ile Ser Glu Ile Ser Pro Asp Cys Val Pro Asn Tyr Ser Asp Met Leu           
    590                 595                 600                           

ccu auu gga uua caa aug aaa aag aag aac agg cuu gau aug gau uuu       2535
Pro Ile Gly Leu Gln Met Lys Lys Lys Asn Arg Leu Asp Met Asp Phe           
605                 610                 615                 620           

guu uug aug gac aaa aua gca guu guu gau cca acg ggu aag uua aug       2583
Val Leu Met Asp Lys Ile Ala Val Val Asp Pro Thr Gly Lys Leu Met           
                625                 630                 635               

aag aua guu agu gac ugu cca uac gac aca ccu agu aaa aau aau cag       2631
Lys Ile Val Ser Asp Cys Pro Tyr Asp Thr Pro Ser Lys Asn Asn Gln           
            640                 645                 650                   

ugu uug cuc cac ucc cuu cug ggu gca cua gau cau aga gau aga aaa       2679
Cys Leu Leu His Ser Leu Leu Gly Ala Leu Asp His Arg Asp Arg Lys           
        655                 660                 665                       

guu uua gug gau gaa agu aau auu gaa aaa uuc uuc caa ugg aug ucc       2727
Val Leu Val Asp Glu Ser Asn Ile Glu Lys Phe Phe Gln Trp Met Ser           
    670                 675                 680                           

gau aau auu agu gau cca gau gug auu gaa gca auu aau guu uau aaa       2775
Asp Asn Ile Ser Asp Pro Asp Val Ile Glu Ala Ile Asn Val Tyr Lys           
685                 690                 695                 700           

aug gag uau gcu ucu gau uuc cca cca gaa gca acu aau uua gau guu       2823
Met Glu Tyr Ala Ser Asp Phe Pro Pro Glu Ala Thr Asn Leu Asp Val           
                705                 710                 715               

uua caa gga auu aaa acu cau aag aaa aug uua cca guu gac cuu ugu       2871
Leu Gln Gly Ile Lys Thr His Lys Lys Met Leu Pro Val Asp Leu Cys           
            720                 725                 730                   

aaa uua cuc uca aaa uau uug gac cgu acu aua auu gua aaa cau gua       2919
Lys Leu Leu Ser Lys Tyr Leu Asp Arg Thr Ile Ile Val Lys His Val           
        735                 740                 745                       

aau aaa guu uug acu uau gga ccg gaa aga ugg gau aac aau aua cca       2967
Asn Lys Val Leu Thr Tyr Gly Pro Glu Arg Trp Asp Asn Asn Ile Pro           
    750                 755                 760                           

aaa aua cuc caa uua gaa aau caa cau uuu agc uau auu gac cga gua       3015
Lys Ile Leu Gln Leu Glu Asn Gln His Phe Ser Tyr Ile Asp Arg Val           
765                 770                 775                 780           

cua gug gau aau auu uug cca uua aaa gca gca guu gag ugu aug guu       3063
Leu Val Asp Asn Ile Leu Pro Leu Lys Ala Ala Val Glu Cys Met Val           
                785                 790                 795               

caa uuu acu uua aca cga gcc gca caa uuu aau aca ccc gau aca cuu       3111
Gln Phe Thr Leu Thr Arg Ala Ala Gln Phe Asn Thr Pro Asp Thr Leu           
            800                 805                 810                   

aaa caa aaa gag uau uau uua gcg aug gca gca gca uac guu uuu aca       3159
Lys Gln Lys Glu Tyr Tyr Leu Ala Met Ala Ala Ala Tyr Val Phe Thr           
        815                 820                 825                       

uau aau ucu aga auu gcu gug ugu ugu aug aau gug aaa ucu aau aag       3207
Tyr Asn Ser Arg Ile Ala Val Cys Cys Met Asn Val Lys Ser Asn Lys           
    830                 835                 840                           

cuu gau gcg aaa uca auu auu ggu auu ugc aca gau auu cug ucu aca       3255
Leu Asp Ala Lys Ser Ile Ile Gly Ile Cys Thr Asp Ile Leu Ser Thr           
845                 850                 855                 860           

auu gcu uuc gua guu ggu aug gga gua ucu agu ggu gau uuu gca uca       3303
Ile Ala Phe Val Val Gly Met Gly Val Ser Ser Gly Asp Phe Ala Ser           
                865                 870                 875               

cgc aug gua aag gcu gag aaa uuu uca aca ucu aug gau aca uuu gca       3351
Arg Met Val Lys Ala Glu Lys Phe Ser Thr Ser Met Asp Thr Phe Ala           
            880                 885                 890                   

ucu agg aca acu aau aag uua gau ucg auu uua ucg aaa gcu uuc ggu       3399
Ser Arg Thr Thr Asn Lys Leu Asp Ser Ile Leu Ser Lys Ala Phe Gly           
        895                 900                 905                       

auu uau aug ucg gaa gau ggc gaa acg guu gca agu uua ucc aaa gau       3447
Ile Tyr Met Ser Glu Asp Gly Glu Thr Val Ala Ser Leu Ser Lys Asp           
    910                 915                 920                           

auu gau aua cua gag aaa uau aaa gca cau acu gua gcc gau uau aug       3495
Ile Asp Ile Leu Glu Lys Tyr Lys Ala His Thr Val Ala Asp Tyr Met           
925                 930                 935                 940           

aau aau aug uca aaa uau caa gaa guu aaa aca uau gua gaa gga guu       3543
Asn Asn Met Ser Lys Tyr Gln Glu Val Lys Thr Tyr Val Glu Gly Val           
                945                 950                 955               

aca aaa cgu aug aca uca cua cac cua uua aau aga gau acc acu aau       3591
Thr Lys Arg Met Thr Ser Leu His Leu Leu Asn Arg Asp Thr Thr Asn           
            960                 965                 970                   

gcu auu caa aau acg caa aau auu aua aga aag agu ugu gau gcc aua       3639
Ala Ile Gln Asn Thr Gln Asn Ile Ile Arg Lys Ser Cys Asp Ala Ile           
        975                 980                 985                       

aug gca guu uug aau gac guu gau aag uug aau aga  aug gaa uca uug      3687
Met Ala Val Leu Asn Asp Val Asp Lys Leu Asn Arg  Met Glu Ser Leu          
    990                 995                 1000                          

aga  cag gaa uuu gug ggc  cuu aag gga gcu ggu  aaa acc uca aca        3732
Arg  Gln Glu Phe Val Gly  Leu Lys Gly Ala Gly  Lys Thr Ser Thr            
1005                 1010                 1015                            

uug  aac aau uau cua aua  cca aau auu gcu aag  cgc uug gcg uug        3777
Leu  Asn Asn Tyr Leu Ile  Pro Asn Ile Ala Lys  Arg Leu Ala Leu            
1020                 1025                 1030                            

aau  cca agc acc uau gca  gca gaa auu gac gcg  aau gga cau ugg        3822
Asn  Pro Ser Thr Tyr Ala  Ala Glu Ile Asp Ala  Asn Gly His Trp            
1035                 1040                 1045                            

aaa  ccc uau aga uau gaa  gau uuu gcu uua aua  gau gau uug uuu        3867
Lys  Pro Tyr Arg Tyr Glu  Asp Phe Ala Leu Ile  Asp Asp Leu Phe            
1050                 1055                 1060                            

aau  cag ggu agu aac gac  ccc uuu aua cca cau  auu gua agg aug        3912
Asn  Gln Gly Ser Asn Asp  Pro Phe Ile Pro His  Ile Val Arg Met            
1065                 1070                 1075                            

gcu  ucc ucu cuu aac uuu  gau uua ccu gga gcu  gac uug agc aau        3957
Ala  Ser Ser Leu Asn Phe  Asp Leu Pro Gly Ala  Asp Leu Ser Asn            
1080                 1085                 1090                            

aaa  gag aaa acu uua agg  gcu aga uuc uug uuu  gcg aca gca aac        4002
Lys  Glu Lys Thr Leu Arg  Ala Arg Phe Leu Phe  Ala Thr Ala Asn            
1095                 1100                 1105                            

guu  gca uau gua aga aug  aag gaa gaa aug ccc  gcu agu gcu cag        4047
Val  Ala Tyr Val Arg Met  Lys Glu Glu Met Pro  Ala Ser Ala Gln            
1110                 1115                 1120                            

gaa  gga uuu uau ggu aga  uuu aag ugu auu caa  uuu auu aau gcc        4092
Glu  Gly Phe Tyr Gly Arg  Phe Lys Cys Ile Gln  Phe Ile Asn Ala            
1125                 1130                 1135                            

aaa  caa ggu auu aau cag  gca aga gau uca gug  gaa uac auc gac        4137
Lys  Gln Gly Ile Asn Gln  Ala Arg Asp Ser Val  Glu Tyr Ile Asp            
1140                 1145                 1150                            

uau  gaa gau cau gau aca  uau gaa uug aga aug  uau gaa gaa caa        4182
Tyr  Glu Asp His Asp Thr  Tyr Glu Leu Arg Met  Tyr Glu Glu Gln            
1155                 1160                 1165                            

auu  aau gaa caa uuc uca  cag auu gaa aga aau  gac cau aua acu        4227
Ile  Asn Glu Gln Phe Ser  Gln Ile Glu Arg Asn  Asp His Ile Thr            
1170                 1175                 1180                            

ggu  gaa cgu aua caa cau  uuu gau ccu ucu acu  aag acu uau gau        4272
Gly  Glu Arg Ile Gln His  Phe Asp Pro Ser Thr  Lys Thr Tyr Asp            
1185                 1190                 1195                            

gac  cau auu uac aaa aua  gga cau uua cau uau  aaa auu gua acc        4317
Asp  His Ile Tyr Lys Ile  Gly His Leu His Tyr  Lys Ile Val Thr            
1200                 1205                 1210                            

uuu  aaa cag uua gaa aca  auu ugu aua gau cag  uuu aau aaa aag        4362
Phe  Lys Gln Leu Glu Thr  Ile Cys Ile Asp Gln  Phe Asn Lys Lys            
1215                 1220                 1225                            

uau  caa cau uac aaa aug  gcu aga gau cgu aaa  ugu gua gug gac        4407
Tyr  Gln His Tyr Lys Met  Ala Arg Asp Arg Lys  Cys Val Val Asp            
1230                 1235                 1240                            

uuu  gaa uau uuu aga aau  auu gau aug aaa uca  gac gca aua gua        4452
Phe  Glu Tyr Phe Arg Asn  Ile Asp Met Lys Ser  Asp Ala Ile Val            
1245                 1250                 1255                            

gaa  aau aug gua cgu aag  ggu uau cuc cca gca  gaa auu gaa gca        4497
Glu  Asn Met Val Arg Lys  Gly Tyr Leu Pro Ala  Glu Ile Glu Ala            
1260                 1265                 1270                            

gca  aga caa acu gua gga  cuu aca gcu gga cca  gau gaa gug cau        4542
Ala  Arg Gln Thr Val Gly  Leu Thr Ala Gly Pro  Asp Glu Val His            
1275                 1280                 1285                            

gcc  aaa ucu gaa ucu aua  auu aau cau uac guu  gua uca guu uuu        4587
Ala  Lys Ser Glu Ser Ile  Ile Asn His Tyr Val  Val Ser Val Phe            
1290                 1295                 1300                            

ggc  gau acu gga acu gga  aaa ucu guu uuu gcu  aca cag cug gcg        4632
Gly  Asp Thr Gly Thr Gly  Lys Ser Val Phe Ala  Thr Gln Leu Ala            
1305                 1310                 1315                            

uua  gau cug uca gac uuu  cug aau uug aaa gua  uau ucu gug gaa        4677
Leu  Asp Leu Ser Asp Phe  Leu Asn Leu Lys Val  Tyr Ser Val Glu            
1320                 1325                 1330                            

gau  aua aau gau acg gcc  cau uua gac uac uua  aau cca agu aua        4722
Asp  Ile Asn Asp Thr Ala  His Leu Asp Tyr Leu  Asn Pro Ser Ile            
1335                 1340                 1345                            

auu  guu uuc cau gau agc  auu uau gau gaa uug  aaa uau guu gca        4767
Ile  Val Phe His Asp Ser  Ile Tyr Asp Glu Leu  Lys Tyr Val Ala            
1350                 1355                 1360                            

uua  uau gau aaa uua cca  aaa cca ugu uua aua  aua acu aca agu        4812
Leu  Tyr Asp Lys Leu Pro  Lys Pro Cys Leu Ile  Ile Thr Thr Ser            
1365                 1370                 1375                            

aau  cau aca uua aaa ugg  cau aga gag aaa uua  ugu aau auu guu        4857
Asn  His Thr Leu Lys Trp  His Arg Glu Lys Leu  Cys Asn Ile Val            
1380                 1385                 1390                            

gau  aau agu acu uca gca  gca gag cgc ucu ucu  agu gcu uug uug        4902
Asp  Asn Ser Thr Ser Ala  Ala Glu Arg Ser Ser  Ser Ala Leu Leu            
1395                 1400                 1405                            

gaa  cau ggu uuc uuu aac  aaa aug aaa aau aaa  auu ggc gga cuu        4947
Glu  His Gly Phe Phe Asn  Lys Met Lys Asn Lys  Ile Gly Gly Leu            
1410                 1415                 1420                            

guu  ucu uau uuu aau uug  uca agu auu aga gaa  ggu uau uug guu        4992
Val  Ser Tyr Phe Asn Leu  Ser Ser Ile Arg Glu  Gly Tyr Leu Val            
1425                 1430                 1435                            

caa  aca uuc cca gga uac  caa cca aca ccu ggu  uau ugu aga aga        5037
Gln  Thr Phe Pro Gly Tyr  Gln Pro Thr Pro Gly  Tyr Cys Arg Arg            
1440                 1445                 1450                            

cua  ggu uug aac acu gca  uuc cac ccg aua ucg  aca gaa gau uug        5082
Leu  Gly Leu Asn Thr Ala  Phe His Pro Ile Ser  Thr Glu Asp Leu            
1455                 1460                 1465                            

aca  ucu aau uua gua uau  uca cag cgu ccu aau  aaa gaa acu aca        5127
Thr  Ser Asn Leu Val Tyr  Ser Gln Arg Pro Asn  Lys Glu Thr Thr            
1470                 1475                 1480                            

acc  auu uuu gca acu uca  gga uac cau uuc cau  cag gau aau aaa        5172
Thr  Ile Phe Ala Thr Ser  Gly Tyr His Phe His  Gln Asp Asn Lys            
1485                 1490                 1495                            

gaa  gug caa uua aac gaa  guc guu aaa gaa guu  uua aug aaa uau        5217
Glu  Val Gln Leu Asn Glu  Val Val Lys Glu Val  Leu Met Lys Tyr            
1500                 1505                 1510                            

aga  gga gcu aag aaa uuc  auu cag ccu gau auu  auc aaa uua gga        5262
Arg  Gly Ala Lys Lys Phe  Ile Gln Pro Asp Ile  Ile Lys Leu Gly            
1515                 1520                 1525                            

gua  uca gaa uuu gag gaa  caa uuu aag aaa uua  aca acu auu gau        5307
Val  Ser Glu Phe Glu Glu  Gln Phe Lys Lys Leu  Thr Thr Ile Asp            
1530                 1535                 1540                            

gua  gaa auu cag ucu aaa  aau auu gag uca uug  auu aaa uua acg        5352
Val  Glu Ile Gln Ser Lys  Asn Ile Glu Ser Leu  Ile Lys Leu Thr            
1545                 1550                 1555                            

aac  gau aga gcu aua cua  gua aac ucu gua acu  gca gcu aga uuu        5397
Asn  Asp Arg Ala Ile Leu  Val Asn Ser Val Thr  Ala Ala Arg Phe            
1560                 1565                 1570                            

guu  ggu ggu ucu aau auu  guu aaa guu ucc agu  aga guc aga uca        5442
Val  Gly Gly Ser Asn Ile  Val Lys Val Ser Ser  Arg Val Arg Ser            
1575                 1580                 1585                            

aau  aau uau ucu uuu aau  ccu cua gau uuu gcu  auu ccu auu aau        5487
Asn  Asn Tyr Ser Phe Asn  Pro Leu Asp Phe Ala  Ile Pro Ile Asn            
1590                 1595                 1600                            

gcu  acu gua ucu gau gca  cua gau aua gca aug  aaa ucu uau agg        5532
Ala  Thr Val Ser Asp Ala  Leu Asp Ile Ala Met  Lys Ser Tyr Arg            
1605                 1610                 1615                            

cua  uua uug agu gca aau  gua gau uau aca gua  uuu auc aaa ugu        5577
Leu  Leu Leu Ser Ala Asn  Val Asp Tyr Thr Val  Phe Ile Lys Cys            
1620                 1625                 1630                            

gaa  gaa uuu ucu ugu aua  ggu auu aac ggc aau  auu uac uau acu        5622
Glu  Glu Phe Ser Cys Ile  Gly Ile Asn Gly Asn  Ile Tyr Tyr Thr            
1635                 1640                 1645                            

uca  gua ccu uuu aau gua  acu ucu uau uca cau  auu gca acu aaa        5667
Ser  Val Pro Phe Asn Val  Thr Ser Tyr Ser His  Ile Ala Thr Lys            
1650                 1655                 1660                            

gua  aua aca uuu uau aaa  gua gau acu aau uca  gau gga aua aca        5712
Val  Ile Thr Phe Tyr Lys  Val Asp Thr Asn Ser  Asp Gly Ile Thr            
1665                 1670                 1675                            

aau  aau uca gaa uua auc  aaa uuu aca ccg gau  gaa uau gcu aaa        5757
Asn  Asn Ser Glu Leu Ile  Lys Phe Thr Pro Asp  Glu Tyr Ala Lys            
1680                 1685                 1690                            

uua  auu auu aca gga gaa  gga gaa caa aaa cuu  uuu gau aag uug        5802
Leu  Ile Ile Thr Gly Glu  Gly Glu Gln Lys Leu  Phe Asp Lys Leu            
1695                 1700                 1705                            

ccu  uau gca gcu ugu aaa  uau auu uau ggc gcu  aga gca gag auu        5847
Pro  Tyr Ala Ala Cys Lys  Tyr Ile Tyr Gly Ala  Arg Ala Glu Ile            
1710                 1715                 1720                            

gaa  cca cau uuu gcg aca  aca uuu acu aaa uac  gaa guu aga aca        5892
Glu  Pro His Phe Ala Thr  Thr Phe Thr Lys Tyr  Glu Val Arg Thr            
1725                 1730                 1735                            

gaa  guu uau gau aau cau  acu aga gag aaa aug  gcu uuc uuu gua        5937
Glu  Val Tyr Asp Asn His  Thr Arg Glu Lys Met  Ala Phe Phe Val            
1740                 1745                 1750                            

auu  uau uca gaa uuu aag  aaa aca auu ugg uau  aaa aua gcu aua        5982
Ile  Tyr Ser Glu Phe Lys  Lys Thr Ile Trp Tyr  Lys Ile Ala Ile            
1755                 1760                 1765                            

ggu  auu uug gcu aua acu  gca uca guu uua aua  auu gaa uua aua        6027
Gly  Ile Leu Ala Ile Thr  Ala Ser Val Leu Ile  Ile Glu Leu Ile            
1770                 1775                 1780                            

aca  caa auu ugg aau aug  uuu auu ggu uua aaa  gaa guu uuu aca        6072
Thr  Gln Ile Trp Asn Met  Phe Ile Gly Leu Lys  Glu Val Phe Thr            
1785                 1790                 1795                            

agu  acc guu caa aaa gau  aau guu aaa gua guu  uau caa guu uua        6117
Ser  Thr Val Gln Lys Asp  Asn Val Lys Val Val  Tyr Gln Val Leu            
1800                 1805                 1810                            

uca  guu aau ccu aaa gag  caa uca gca gaa guu  aaa guu uau ggu        6162
Ser  Val Asn Pro Lys Glu  Gln Ser Ala Glu Val  Lys Val Tyr Gly            
1815                 1820                 1825                            

uuu  aaa gau gau uua gau  uca uuc ucu aau aaa  gag uua ucc aau        6207
Phe  Lys Asp Asp Leu Asp  Ser Phe Ser Asn Lys  Glu Leu Ser Asn            
1830                 1835                 1840                            

uua  auu aua gau gau auu  gau guu gcg aaa uua  gau gau uca auc        6252
Leu  Ile Ile Asp Asp Ile  Asp Val Ala Lys Leu  Asp Asp Ser Ile            
1845                 1850                 1855                            

ccc  gca gau acu gua auu  aaa gcc uug gau aug  ucg caa aug acu        6297
Pro  Ala Asp Thr Val Ile  Lys Ala Leu Asp Met  Ser Gln Met Thr            
1860                 1865                 1870                            

gug  cau agu gau ugg aau  aag aaa gac uuu gcu  aaa aac aaa gua        6342
Val  His Ser Asp Trp Asn  Lys Lys Asp Phe Ala  Lys Asn Lys Val            
1875                 1880                 1885                            

ccu  aca uug guc cau aga  aug uug gau aug cgc  guu cau agc gau        6387
Pro  Thr Leu Val His Arg  Met Leu Asp Met Arg  Val His Ser Asp            
1890                 1895                 1900                            

aaa  ucc cag gau aau aag  aaa auu ucu agg aag  gcu aac cgu gug        6432
Lys  Ser Gln Asp Asn Lys  Lys Ile Ser Arg Lys  Ala Asn Arg Val            
1905                 1910                 1915                            

gag  aga auu uua gaa aau  aug aca guu aaa ggu  gaa uuc gau uuu        6477
Glu  Arg Ile Leu Glu Asn  Met Thr Val Lys Gly  Glu Phe Asp Phe            
1920                 1925                 1930                            

auu  aaa cau aaa auu aca  aac ucu cuc ggc aag  guu guu guu ucc        6522
Ile  Lys His Lys Ile Thr  Asn Ser Leu Gly Lys  Val Val Val Ser            
1935                 1940                 1945                            

gca  agc ggu gua guu aag  acg guc gua ggu aug  aac auu aaa gga        6567
Ala  Ser Gly Val Val Lys  Thr Val Val Gly Met  Asn Ile Lys Gly            
1950                 1955                 1960                            

cau  uau gua auu ugu cca  gca cau guu uau cca  guu gau aca gcg        6612
His  Tyr Val Ile Cys Pro  Ala His Val Tyr Pro  Val Asp Thr Ala            
1965                 1970                 1975                            

uuc  cau uau gca aau uuu  acc ccg uuu aau acg  ggu aaa aau uac        6657
Phe  His Tyr Ala Asn Phe  Thr Pro Phe Asn Thr  Gly Lys Asn Tyr            
1980                 1985                 1990                            

aca  aug guc cca aug guc  ugu agu aga gua gau  gau uug gcu uug        6702
Thr  Met Val Pro Met Val  Cys Ser Arg Val Asp  Asp Leu Ala Leu            
1995                 2000                 2005                            

uuu  uac aua acu gau aaa  uua cau cca uua gcg  aaa gau auu aca        6747
Phe  Tyr Ile Thr Asp Lys  Leu His Pro Leu Ala  Lys Asp Ile Thr            
2010                 2015                 2020                            

cau  cau uuu gau gau cag  gaa cgu uua uau acu  cga cca uuc gag        6792
His  His Phe Asp Asp Gln  Glu Arg Leu Tyr Thr  Arg Pro Phe Glu            
2025                 2030                 2035                            

uug  ccu uau aug cau uua  cga acu ggu aau gua  gua ucu ugg aaa        6837
Leu  Pro Tyr Met His Leu  Arg Thr Gly Asn Val  Val Ser Trp Lys            
2040                 2045                 2050                            

ggu  gga gau gcu auu gga  uug cga uca uug guu  aca aaa guu cau        6882
Gly  Gly Asp Ala Ile Gly  Leu Arg Ser Leu Val  Thr Lys Val His            
2055                 2060                 2065                            

caa  gac aug uua uua aca  gaa gga aaa ccu aug  gua gca ggu caa        6927
Gln  Asp Met Leu Leu Thr  Glu Gly Lys Pro Met  Val Ala Gly Gln            
2070                 2075                 2080                            

uuu  ugg agu acg guu acu  cgc cuu acu aaa ggc  gau ugu gga uuc        6972
Phe  Trp Ser Thr Val Thr  Arg Leu Thr Lys Gly  Asp Cys Gly Phe            
2085                 2090                 2095                            

cca  aua aua gau acu aac  ucu cau aaa aua uuu  ucu auu uau ugu        7017
Pro  Ile Ile Asp Thr Asn  Ser His Lys Ile Phe  Ser Ile Tyr Cys            
2100                 2105                 2110                            

gga  gau aau aau ggc guu  aau gcu auu uau gga  aau aug gua aca        7062
Gly  Asp Asn Asn Gly Val  Asn Ala Ile Tyr Gly  Asn Met Val Thr            
2115                 2120                 2125                            

uca  aca uug guu aag aaa  aug auu gac uuu gcu  gaa ggu gua ucu        7107
Ser  Thr Leu Val Lys Lys  Met Ile Asp Phe Ala  Glu Gly Val Ser            
2130                 2135                 2140                            

gaa  gua cac gcu uuu acu  cgu uau agu cca ccc  aug gaa gag uuc        7152
Glu  Val His Ala Phe Thr  Arg Tyr Ser Pro Pro  Met Glu Glu Phe            
2145                 2150                 2155                            

uuu  gau gca gaa gau acu  ggu guu aug aag uuu  ucc uau cca ucu        7197
Phe  Asp Ala Glu Asp Thr  Gly Val Met Lys Phe  Ser Tyr Pro Ser            
2160                 2165                 2170                            

gga  gaa caa cau auu guu  aug ccu guu gaa acu  ugu gau uau auc        7242
Gly  Glu Gln His Ile Val  Met Pro Val Glu Thr  Cys Asp Tyr Ile            
2175                 2180                 2185                            

uca  aaa gca uau gaa acu  gaa aac uau uac ccu  ugc aug gau gga        7287
Ser  Lys Ala Tyr Glu Thr  Glu Asn Tyr Tyr Pro  Cys Met Asp Gly            
2190                 2195                 2200                            

gaa  uuu acg agg aau auc  gcg uac agu agu gau  ugu caa aag aac        7332
Glu  Phe Thr Arg Asn Ile  Ala Tyr Ser Ser Asp  Cys Gln Lys Asn            
2205                 2210                 2215                            

gca  uuu aug aaa ccu aaa  uau caa cga aca ccu  uuu gcu gaa gaa        7377
Ala  Phe Met Lys Pro Lys  Tyr Gln Arg Thr Pro  Phe Ala Glu Glu            
2220                 2225                 2230                            

auu  uua acu caa uau cca  caa auu aaa gau gau  ugu aga aau gcc        7422
Ile  Leu Thr Gln Tyr Pro  Gln Ile Lys Asp Asp  Cys Arg Asn Ala            
2235                 2240                 2245                            

gcu  acu gac cca agg uua  gua gaa gau aaa uca  aaa uua gua aau        7467
Ala  Thr Asp Pro Arg Leu  Val Glu Asp Lys Ser  Lys Leu Val Asn            
2250                 2255                 2260                            

uca  guu aaa gga gac cca  uca auu guu aug aca  caa cug gca aag        7512
Ser  Val Lys Gly Asp Pro  Ser Ile Val Met Thr  Gln Leu Ala Lys            
2265                 2270                 2275                            

auu  aau gac ccc aua gau  gca gcu ggu gga cuu  aug ggu gag aag        7557
Ile  Asn Asp Pro Ile Asp  Ala Ala Gly Gly Leu  Met Gly Glu Lys            
2280                 2285                 2290                            

uuu  aug gaa gaa gca gcu  gaa aug uua aca gaa  gag uau auu gac        7602
Phe  Met Glu Glu Ala Ala  Glu Met Leu Thr Glu  Glu Tyr Ile Asp            
2295                 2300                 2305                            

uug  uau agc ggu uuu gac  cau aga uuu uug acu  aca gaa gaa acg        7647
Leu  Tyr Ser Gly Phe Asp  His Arg Phe Leu Thr  Thr Glu Glu Thr            
2310                 2315                 2320                            

aua  aau ggu auu gca agu  ccu caa ucg gau uua  caa ggu cau uua        7692
Ile  Asn Gly Ile Ala Ser  Pro Gln Ser Asp Leu  Gln Gly His Leu            
2325                 2330                 2335                            

gaa  gcu gua aau aga gau  gcg ucu gca ggu cau  ugg ugu aug cua        7737
Glu  Ala Val Asn Arg Asp  Ala Ser Ala Gly His  Trp Cys Met Leu            
2340                 2345                 2350                            

aau  gga uau cau aaa auu  ucu gau uua uua gaa  gaa ggu ggu agu        7782
Asn  Gly Tyr His Lys Ile  Ser Asp Leu Leu Glu  Glu Gly Gly Ser            
2355                 2360                 2365                            

uac  ccu uca ggu caa cua  cgg uau cau uuu aag  aaa gag aau aaa        7827
Tyr  Pro Ser Gly Gln Leu  Arg Tyr His Phe Lys  Lys Glu Asn Lys            
2370                 2375                 2380                            

gua  auu gcu aaa uua gaa  aaa cau aua uca caa  caa aag aag aug        7872
Val  Ile Ala Lys Leu Glu  Lys His Ile Ser Gln  Gln Lys Lys Met            
2385                 2390                 2395                            

ugg  gca aaa ggu auu cgu  uac gaa ggu uua acu  aaa gau aau uua        7917
Trp  Ala Lys Gly Ile Arg  Tyr Glu Gly Leu Thr  Lys Asp Asn Leu            
2400                 2405                 2410                            

aaa  gcc gaa uua aga cca  uuu gaa aaa gug aga  auu gga aaa acg        7962
Lys  Ala Glu Leu Arg Pro  Phe Glu Lys Val Arg  Ile Gly Lys Thr            
2415                 2420                 2425                            

cgu  gua uuu gaa agu uuu  gac uuc uuu aca acc  uuu aac cau aga        8007
Arg  Val Phe Glu Ser Phe  Asp Phe Phe Thr Thr  Phe Asn His Arg            
2430                 2435                 2440                            

caa  cua uuu gga acg aua  caa gcu gca aug aag  aag cag aga gcu        8052
Gln  Leu Phe Gly Thr Ile  Gln Ala Ala Met Lys  Lys Gln Arg Ala            
2445                 2450                 2455                            

cgg  gga aca ugu caa auu  gga uua gcu caa uau  gau uuu acg cac        8097
Arg  Gly Thr Cys Gln Ile  Gly Leu Ala Gln Tyr  Asp Phe Thr His            
2460                 2465                 2470                            

uug  uau aau aga uug cug  cag acc ucu cca uuu  gcu guu cac ggg        8142
Leu  Tyr Asn Arg Leu Leu  Gln Thr Ser Pro Phe  Ala Val His Gly            
2475                 2480                 2485                            

gac  uuc gag gcc ugg gau  aag cau aug gau ugg  uuu uca gua cag        8187
Asp  Phe Glu Ala Trp Asp  Lys His Met Asp Trp  Phe Ser Val Gln            
2490                 2495                 2500                            

uug  gcu ugu aag aug ugg  acg aag guu uua ugg  aaa uca cca caa        8232
Leu  Ala Cys Lys Met Trp  Thr Lys Val Leu Trp  Lys Ser Pro Gln            
2505                 2510                 2515                            

uuc  caa cau ugg aau gau  aaa aua aau gca cac  aaa uuu gaa ugu        8277
Phe  Gln His Trp Asn Asp  Lys Ile Asn Ala His  Lys Phe Glu Cys            
2520                 2525                 2530                            

gaa  gaa aau uua uac cug  aug uug gaa acu gca  aug uuu ucu aau        8322
Glu  Glu Asn Leu Tyr Leu  Met Leu Glu Thr Ala  Met Phe Ser Asn            
2535                 2540                 2545                            

gug  uau gcu guu acu uug  gca gau gga cau aua  aua guu aaa gaa        8367
Val  Tyr Ala Val Thr Leu  Ala Asp Gly His Ile  Ile Val Lys Glu            
2550                 2555                 2560                            

aga  ucu caa ugu uca gga  gua gua gaa acg aca  acu uua aau ucu        8412
Arg  Ser Gln Cys Ser Gly  Val Val Glu Thr Thr  Thr Leu Asn Ser            
2565                 2570                 2575                            

acu  guu aau gac auu aag  ugu gug gcu guu aua  uug uau cug aua        8457
Thr  Val Asn Asp Ile Lys  Cys Val Ala Val Ile  Leu Tyr Leu Ile            
2580                 2585                 2590                            

aag  aaa cau aac gug gug  cuu aga acu cua ggu  gcu ucg gaa gca        8502
Lys  Lys His Asn Val Val  Leu Arg Thr Leu Gly  Ala Ser Glu Ala            
2595                 2600                 2605                            

gau  gca agg aag uac uau  gaa gau uac uug gaa  aca uug gag cuu        8547
Asp  Ala Arg Lys Tyr Tyr  Glu Asp Tyr Leu Glu  Thr Leu Glu Leu            
2610                 2615                 2620                            

uca  aag aag agu aga aaa  gcu uua uua aca ucg  aaa cau auu uau        8592
Ser  Lys Lys Ser Arg Lys  Ala Leu Leu Thr Ser  Lys His Ile Tyr            
2625                 2630                 2635                            

uca  ccg auu aua cca gau  aga aga acg auu aaa  caa aac uuu gau        8637
Ser  Pro Ile Ile Pro Asp  Arg Arg Thr Ile Lys  Gln Asn Phe Asp            
2640                 2645                 2650                            

aug  aua uau uau ggc gau  gau auu ggu auu gua  gua aau uua gaa        8682
Met  Ile Tyr Tyr Gly Asp  Asp Ile Gly Ile Val  Val Asn Leu Glu            
2655                 2660                 2665                            

uuu  cug uuu auu gua aau  uuu guu uca auu aaa  aau gcu uau aaa        8727
Phe  Leu Phe Ile Val Asn  Phe Val Ser Ile Lys  Asn Ala Tyr Lys            
2670                 2675                 2680                            

uac  uug uuc ggu auu aau  uug gac uca ccu cau  aaa gau ggg uca        8772
Tyr  Leu Phe Gly Ile Asn  Leu Asp Ser Pro His  Lys Asp Gly Ser            
2685                 2690                 2695                            

uua  gua ccu uuu gug ccu  uua aau gaa uug gaa  uuu guu agu aga        8817
Leu  Val Pro Phe Val Pro  Leu Asn Glu Leu Glu  Phe Val Ser Arg            
2700                 2705                 2710                            

acu  uuu gau uau cau ucu  gau acu aga acc guu  uau ccu aaa uua        8862
Thr  Phe Asp Tyr His Ser  Asp Thr Arg Thr Val  Tyr Pro Lys Leu            
2715                 2720                 2725                            

aaa  gaa caa uca auu ugg  aga cuu uug uuc ugg  ugu acu aau uua        8907
Lys  Glu Gln Ser Ile Trp  Arg Leu Leu Phe Trp  Cys Thr Asn Leu            
2730                 2735                 2740                            

cgu  cca gag cag aua gaa  ucc aau aug auu gca  aug gcu aac gaa        8952
Arg  Pro Glu Gln Ile Glu  Ser Asn Met Ile Ala  Met Ala Asn Glu            
2745                 2750                 2755                            

uug  uuc cuu uau gaa gaa  agu aaa uac aga uug  uuu agu uca auu        8997
Leu  Phe Leu Tyr Glu Glu  Ser Lys Tyr Arg Leu  Phe Ser Ser Ile            
2760                 2765                 2770                            

guc  aac gca aua aua uca  cca uau cug aaa cgc  caa uau aau ugg        9042
Val  Asn Ala Ile Ile Ser  Pro Tyr Leu Lys Arg  Gln Tyr Asn Trp            
2775                 2780                 2785                            

aau  uug aua uua cca agu  uau aga cuu gga agg  gua gca uuu gag        9087
Asn  Leu Ile Leu Pro Ser  Tyr Arg Leu Gly Arg  Val Ala Phe Glu            
2790                 2795                 2800                            

gag  aug ucg cau gaa cug  aag gag gug ccu cac  ucc agc acc ugu        9132
Glu  Met Ser His Glu Leu  Lys Glu Val Pro His  Ser Ser Thr Cys            
2805                 2810                 2815                            

uuu  acu gaa uug gag auu  cau uca auu uua cag  aaa gcg caa aau        9177
Phe  Thr Glu Leu Glu Ile  His Ser Ile Leu Gln  Lys Ala Gln Asn            
2820                 2825                 2830                            

aua  gga agc aac uga cuaaggacac uuccucuuuu guaauccgua aagaucgaac      9232
Ile  Gly Ser Asn                                                          
2835                                                                      

aaccuagggc aacgccgguc uuauuauacg ccaaacaagc uuugccgauc ugagccuggg     9292

agcucucggc aaagcagcuu gagaucgaag gagaggagag gaagaggaga guaucucaag     9352

cauguuuggc guauuauacc agcacguucg uagaagggau cugagccugg gagcucuccc     9412

uucuacgucu aacaugcccu cguguagcuc auuagcuccg agggcauguu agauguguug     9472

guauuauaaa uuucucucaa agcuucggga ucugagccug ggagcucucc cgaagcuuaa     9532

uugacugcuc guguagcuca uuagcuccga gcagucaauu cagggaaauu uauuaucuua     9592

cguugggcaa guuucgaucu gagccuggga gcucucgaaa uuugcgccga agcuucucgu     9652

guagcucauu agcuccgaga agcuucggcc caacgugaga uuaucuuguc caaaccccag     9712

aacgaucuga gccugggagc ucucguucug gggcguaagc acucucgugu agcucauuag     9772

cuccgagagu gcuuacguug ggcaagauua ucggccacac ggauccugcg cucguguagc     9832

ucauuagcuc cgagcgcagg auaauccgag auaccgaggg aguggugagg augaggcgag     9892

uaucucggau gcguguggcc gauuauuuug caaaauuucu ugugcagauc ugagccuggg     9952

agcucucugc auaagagguu cccaacucgu guagcucauu agcuccgagu ugggaaccua    10012

guuugcaaaa uuauacuuga agggauacau caucgaucug agccugggag cucucgauga    10072

uguaccccuu ggucucgugu agcucauuag cuccgagacc aaggggcucu ucacguauua    10132

uuguguauuc aaugguggaa agaucugagc cugggagcuc ucuuuccacc aacgccaagu    10192

cucguguagc ucauuagcuc cgagacuugg cguuaaagua cacaauuauc cuaguuugca    10252

aaauuucuug aucugagccu gggagcucuc aagaaauuua uaucaagacu cguguagcuc    10312

auuagcuccg agucuugaua uuuuaaacua cgauuauacg ccagccacua guugcggauc    10372

ugagccuggg agcucuccgc aacuaauagu gagcucgaag gagaggagag gaagaggaga    10432

gagcucacua auggcuggcg uauuauugcu gaaguucuuu gcuucagauc ugagccuggg    10492

agcucucuga agcaaaggcu gaucaguuuc ucguguagcu cauuagcucc gagaaauuga    10552

ucaccaacuu cagcaauuau uggaaucuaa uuauauuuau gaucugagcc ugggagcucu    10612

cauaaauaua auaugaagag aacucgugua gcucauuagc uccgaguuuu cuucguuuag    10672

auuccaauua uaagccaaaa uggauucaau ugaucugagc cugggagcuc ucgauugaau    10732

ccgguuaaua gcuucucgug uagcucauua gcuccgagaa guuauugcau uuuggcuuau    10792

uauguuauau acuaaaugca auagaucuga gccugggagc ucucuauugc auuuuggcuu    10852

ugagcacucg uguagcucau uagcuccgag ugcuuaaagu aaaguauaua acauuauauu    10912

aucggccacg cucuagaugc gcucguguag cucauuagcu ccgagcgcau cuauuagaga    10972

gagaccgagg gaguggugag gaugaggcga gucucucucu aaagcguggc cgauuauucc    11032

augauaucgu gaacaugauc ugagccuggg agcucucaug uucacgucau ggaugcucgu    11092

guagcucauu agcuccgagc auccaugaua ucgugaaauu auaggggcua ucucuuccuu    11152

ugaucugagc cugggagcuc ucaaaggaag acacaaauac cucguguagc ucauuagcuc    11212

cgagguauuu gugcuagcuc cuauuauacc augguaaauu cuucuaugau cugagccugg    11272

gagcucucau agaagaacaa agaaaacucg uguagcucau uagcuccgag uuuucuuugc    11332

uaccauggua uuauuguagu ugggucuuuu ccaggaucug agccugggag cucuccugga    11392

aaagacuaaa ccaacucgug uagcucauua gcuccgaguu gguuuaguag caacugcaau    11452

uaugaccggc guugccuuag gccgguaccc cggagcgacg gugaaggacg gguccaguag    11512

uucgcuacug uugaguagag ugugagcucc gucgcaccgg aacaaggcac guaggagacg    11572

gucgggucca gauauucgua ucugucgagu agaguguggg cuccuacgug cuuauuggac    11632

augcggagac ggucgggucc agauauucgu aucugucgag uagagugugg gcuccgcaug    11692

uccuuauugg gugcauggag acggucgggu ccagauauuc guaucugucg aguagagugu    11752

gggcuccaug cacccuuauu gacgccaacu gaaugaaaug gugaaggacg gguccaggug    11812

uggcugcuuc ggcagugcag cuuguugagu agagugugag cuccguaacu agucgcgucu    11872

uauugguaac cuauuugggg accucacuuu uaguugcuag cuaacaaugg gggccuuaaa    11932

auuaucuuau uaccuuaauu gguuguaagu gcugaauuuu aagggggccg cgcauauugc    11992

guaguaagac cugggccuug cauguagcau uauaaguccc acucguuaua gcuuaaaucg    12052

uaccuuagcc cguacgagac aagaagugaa uuauauuuaa ccaccauaua uuaaucauuu    12112

aguauauaag guagauauua gaaauuaaau aauauagaaa ugaugaauaa ccuaucagcu    12172

ugguaauugc cuaaaugcgu cuguuuucug ugucaauuuu agcguaagcu ggccuugaca    12232

cuuuuaaccg gugcaugaau agauuauuuu uaaaauuugu auuuuuacgu aaguuugccu    12292

acaaaauuuu acauuucgaa acaaucauga auagaauaac aguaaaagug cguuagucac    12352

guggcgcacc uauauuaacu uuuuuaacgu uuauuucauu aguauagguu auucauuaua    12412

auauauugua cauauacuau aauucccaaa uuuauguuug uuauuguaca cccccgauua    12472

gucgguuuau auuuauauau uuggcucugc gaaugcaguu aaacgcuacc acuuuucggg    12532

gacuaucuaa ucuuuauaua aaauuaguua gucggauuuu agggccuuca gcccucuaau    12592

cuuuuuauug aaaaaaaaaa aaaaaaaaaa                                     12622


<210>  101
<211>  2838
<212>  PRT
<213>  synthetic construct

<400>  101

Met Glu Ser Ser Asn Lys Asn Met Cys Thr Gly Phe Pro Gln Thr Leu 
1               5                   10                  15      


Lys Ile Ser Thr Glu Ile Ser Ile Ile Asn Gln Ser Ser Gln Thr Pro 
            20                  25                  30          


Arg Asp Trp Ser Tyr Val Gln Glu Asn Met Gln Gln Phe Lys Asn Tyr 
        35                  40                  45              


Leu Gln Leu Ala Trp Ile Glu Val Pro Asn Asn Ile Thr Ile Gly Asn 
    50                  55                  60                  


Phe Asp Val Phe Glu Asp Asn Met Pro Ile Ala His Ala Ile Ser Ser 
65                  70                  75                  80  


Asp Leu His Gln Thr Ala Gly Ile Ala Gly Val Leu Arg Gln Asn Tyr 
                85                  90                  95      


Phe Lys Asn Leu Pro Lys Val Asn Val Asn Lys Ser Asn Ile Gly Thr 
            100                 105                 110         


Leu Tyr Leu Tyr Pro Asn Lys Asn Leu Thr Arg Gln Ile Ile Gly Leu 
        115                 120                 125             


Ile Thr Lys Asp Ile Tyr Tyr Leu Lys Pro Thr Tyr Ala Ser Leu Phe 
    130                 135                 140                 


Thr Thr Leu Ile Glu Leu Arg Lys Tyr Leu Ile Asn Asn Lys Ile Lys 
145                 150                 155                 160 


Asn Ile Cys Leu Pro Met Val Gly Cys Asn Lys Asp Lys Leu Asn Pro 
                165                 170                 175     


Leu Ala Val Leu Pro Met Leu Met Tyr Cys Leu Gly Asn Ile Glu Thr 
            180                 185                 190         


Gln Val Lys Ile Thr Asn Lys Gly Val Tyr Phe Asn Tyr Gln Pro Ile 
        195                 200                 205             


Pro Val Ala Pro Lys Ile Asn Lys Ile Lys Phe Ser Lys Gln Met Glu 
    210                 215                 220                 


Lys Val Asn Tyr Asp Gln Thr Val Asp Thr Phe Glu Thr Asn Tyr Val 
225                 230                 235                 240 


Lys Pro Lys Lys Phe Lys Ala Lys Val Thr Phe Glu Pro Ser Leu Leu 
                245                 250                 255     


Asn Leu Asp Ser Asn Ser Ile Ile Ile Asn Glu Ser Lys Thr Val Lys 
            260                 265                 270         


Gln Ile Tyr Lys Ala Lys Leu Glu Lys Val Ile Tyr Gln Arg Ser Thr 
        275                 280                 285             


Val Tyr Glu Pro Gln Lys Lys Thr Tyr Val Val Glu Ala Phe Ser Cys 
    290                 295                 300                 


Lys Gln Pro Lys Pro Ile Val Lys Ile Phe Lys Met Lys Gln Ala Ile 
305                 310                 315                 320 


Leu Thr Gln Thr Asp Leu Lys Glu Asn Asn Asn Glu Leu Ile Lys Glu 
                325                 330                 335     


Arg Asn Ser Ile Asp Tyr Tyr Lys Phe Val Thr Pro Asn Thr Val Lys 
            340                 345                 350         


Ala Ile Ile Gly Tyr Asp Lys Val Glu Ser Val Leu Thr Phe Asp Leu 
        355                 360                 365             


Asp Arg Lys Arg Arg Cys Gly Glu Lys Ala Phe Val His Gly Lys Ser 
    370                 375                 380                 


Leu Lys Ser Ile Ala Lys Arg Gln Leu Cys Tyr Ser Tyr Val Pro Ser 
385                 390                 395                 400 


Leu Asn Ser Val Gln Val Tyr Ile Lys Met Leu Gln Leu Thr Ala Gln 
                405                 410                 415     


Lys Gln Val Phe Gly His Val Val Thr Lys Ile Gln Glu Ser Ile Ala 
            420                 425                 430         


Asn Met Asp Val His Gly Met Gln Ile Asn Asn Ile Pro Glu Glu Leu 
        435                 440                 445             


Met Lys Ser Leu Ser Arg Thr Ile Leu Glu Gln Leu Gln Leu Asp Thr 
    450                 455                 460                 


Lys Val Ile Lys Pro Val Leu Leu Ala Asn Ile Leu Asn Cys Phe Val 
465                 470                 475                 480 


Asn Val Val Cys Ala Leu Ile Ile Ile Phe Thr Ala Lys Ser Lys Val 
                485                 490                 495     


Ala Ser Gly Ala Ala Ile Val Gln Ile Ile Ser Asn Ile Leu Thr Leu 
            500                 505                 510         


Met Leu Asp Ile Gly Ile Tyr Tyr Ser Leu Lys His Met Thr Glu Glu 
        515                 520                 525             


Arg Ile Lys Ala Ile Thr Thr Thr Ile Thr Gln Asp Ala Val Gln Lys 
    530                 535                 540                 


Val Met Lys Gln His Gly Val Thr Met Met Ala Ser Asp Lys Val Ile 
545                 550                 555                 560 


Thr Ala Met Gln Asn Val Asp Leu Asn Asp Ala Lys Ser Ile Lys His 
                565                 570                 575     


Phe Ile Lys Glu Phe Glu Lys Glu Glu Asp Thr Asp Ile Ser Glu Ile 
            580                 585                 590         


Ser Pro Asp Cys Val Pro Asn Tyr Ser Asp Met Leu Pro Ile Gly Leu 
        595                 600                 605             


Gln Met Lys Lys Lys Asn Arg Leu Asp Met Asp Phe Val Leu Met Asp 
    610                 615                 620                 


Lys Ile Ala Val Val Asp Pro Thr Gly Lys Leu Met Lys Ile Val Ser 
625                 630                 635                 640 


Asp Cys Pro Tyr Asp Thr Pro Ser Lys Asn Asn Gln Cys Leu Leu His 
                645                 650                 655     


Ser Leu Leu Gly Ala Leu Asp His Arg Asp Arg Lys Val Leu Val Asp 
            660                 665                 670         


Glu Ser Asn Ile Glu Lys Phe Phe Gln Trp Met Ser Asp Asn Ile Ser 
        675                 680                 685             


Asp Pro Asp Val Ile Glu Ala Ile Asn Val Tyr Lys Met Glu Tyr Ala 
    690                 695                 700                 


Ser Asp Phe Pro Pro Glu Ala Thr Asn Leu Asp Val Leu Gln Gly Ile 
705                 710                 715                 720 


Lys Thr His Lys Lys Met Leu Pro Val Asp Leu Cys Lys Leu Leu Ser 
                725                 730                 735     


Lys Tyr Leu Asp Arg Thr Ile Ile Val Lys His Val Asn Lys Val Leu 
            740                 745                 750         


Thr Tyr Gly Pro Glu Arg Trp Asp Asn Asn Ile Pro Lys Ile Leu Gln 
        755                 760                 765             


Leu Glu Asn Gln His Phe Ser Tyr Ile Asp Arg Val Leu Val Asp Asn 
    770                 775                 780                 


Ile Leu Pro Leu Lys Ala Ala Val Glu Cys Met Val Gln Phe Thr Leu 
785                 790                 795                 800 


Thr Arg Ala Ala Gln Phe Asn Thr Pro Asp Thr Leu Lys Gln Lys Glu 
                805                 810                 815     


Tyr Tyr Leu Ala Met Ala Ala Ala Tyr Val Phe Thr Tyr Asn Ser Arg 
            820                 825                 830         


Ile Ala Val Cys Cys Met Asn Val Lys Ser Asn Lys Leu Asp Ala Lys 
        835                 840                 845             


Ser Ile Ile Gly Ile Cys Thr Asp Ile Leu Ser Thr Ile Ala Phe Val 
    850                 855                 860                 


Val Gly Met Gly Val Ser Ser Gly Asp Phe Ala Ser Arg Met Val Lys 
865                 870                 875                 880 


Ala Glu Lys Phe Ser Thr Ser Met Asp Thr Phe Ala Ser Arg Thr Thr 
                885                 890                 895     


Asn Lys Leu Asp Ser Ile Leu Ser Lys Ala Phe Gly Ile Tyr Met Ser 
            900                 905                 910         


Glu Asp Gly Glu Thr Val Ala Ser Leu Ser Lys Asp Ile Asp Ile Leu 
        915                 920                 925             


Glu Lys Tyr Lys Ala His Thr Val Ala Asp Tyr Met Asn Asn Met Ser 
    930                 935                 940                 


Lys Tyr Gln Glu Val Lys Thr Tyr Val Glu Gly Val Thr Lys Arg Met 
945                 950                 955                 960 


Thr Ser Leu His Leu Leu Asn Arg Asp Thr Thr Asn Ala Ile Gln Asn 
                965                 970                 975     


Thr Gln Asn Ile Ile Arg Lys Ser Cys Asp Ala Ile Met Ala Val Leu 
            980                 985                 990         


Asn Asp Val Asp Lys Leu Asn Arg  Met Glu Ser Leu Arg  Gln Glu Phe 
        995                 1000                 1005             


Val Gly  Leu Lys Gly Ala Gly  Lys Thr Ser Thr Leu  Asn Asn Tyr 
    1010                 1015                 1020             


Leu Ile  Pro Asn Ile Ala Lys  Arg Leu Ala Leu Asn  Pro Ser Thr 
    1025                 1030                 1035             


Tyr Ala  Ala Glu Ile Asp Ala  Asn Gly His Trp Lys  Pro Tyr Arg 
    1040                 1045                 1050             


Tyr Glu  Asp Phe Ala Leu Ile  Asp Asp Leu Phe Asn  Gln Gly Ser 
    1055                 1060                 1065             


Asn Asp  Pro Phe Ile Pro His  Ile Val Arg Met Ala  Ser Ser Leu 
    1070                 1075                 1080             


Asn Phe  Asp Leu Pro Gly Ala  Asp Leu Ser Asn Lys  Glu Lys Thr 
    1085                 1090                 1095             


Leu Arg  Ala Arg Phe Leu Phe  Ala Thr Ala Asn Val  Ala Tyr Val 
    1100                 1105                 1110             


Arg Met  Lys Glu Glu Met Pro  Ala Ser Ala Gln Glu  Gly Phe Tyr 
    1115                 1120                 1125             


Gly Arg  Phe Lys Cys Ile Gln  Phe Ile Asn Ala Lys  Gln Gly Ile 
    1130                 1135                 1140             


Asn Gln  Ala Arg Asp Ser Val  Glu Tyr Ile Asp Tyr  Glu Asp His 
    1145                 1150                 1155             


Asp Thr  Tyr Glu Leu Arg Met  Tyr Glu Glu Gln Ile  Asn Glu Gln 
    1160                 1165                 1170             


Phe Ser  Gln Ile Glu Arg Asn  Asp His Ile Thr Gly  Glu Arg Ile 
    1175                 1180                 1185             


Gln His  Phe Asp Pro Ser Thr  Lys Thr Tyr Asp Asp  His Ile Tyr 
    1190                 1195                 1200             


Lys Ile  Gly His Leu His Tyr  Lys Ile Val Thr Phe  Lys Gln Leu 
    1205                 1210                 1215             


Glu Thr  Ile Cys Ile Asp Gln  Phe Asn Lys Lys Tyr  Gln His Tyr 
    1220                 1225                 1230             


Lys Met  Ala Arg Asp Arg Lys  Cys Val Val Asp Phe  Glu Tyr Phe 
    1235                 1240                 1245             


Arg Asn  Ile Asp Met Lys Ser  Asp Ala Ile Val Glu  Asn Met Val 
    1250                 1255                 1260             


Arg Lys  Gly Tyr Leu Pro Ala  Glu Ile Glu Ala Ala  Arg Gln Thr 
    1265                 1270                 1275             


Val Gly  Leu Thr Ala Gly Pro  Asp Glu Val His Ala  Lys Ser Glu 
    1280                 1285                 1290             


Ser Ile  Ile Asn His Tyr Val  Val Ser Val Phe Gly  Asp Thr Gly 
    1295                 1300                 1305             


Thr Gly  Lys Ser Val Phe Ala  Thr Gln Leu Ala Leu  Asp Leu Ser 
    1310                 1315                 1320             


Asp Phe  Leu Asn Leu Lys Val  Tyr Ser Val Glu Asp  Ile Asn Asp 
    1325                 1330                 1335             


Thr Ala  His Leu Asp Tyr Leu  Asn Pro Ser Ile Ile  Val Phe His 
    1340                 1345                 1350             


Asp Ser  Ile Tyr Asp Glu Leu  Lys Tyr Val Ala Leu  Tyr Asp Lys 
    1355                 1360                 1365             


Leu Pro  Lys Pro Cys Leu Ile  Ile Thr Thr Ser Asn  His Thr Leu 
    1370                 1375                 1380             


Lys Trp  His Arg Glu Lys Leu  Cys Asn Ile Val Asp  Asn Ser Thr 
    1385                 1390                 1395             


Ser Ala  Ala Glu Arg Ser Ser  Ser Ala Leu Leu Glu  His Gly Phe 
    1400                 1405                 1410             


Phe Asn  Lys Met Lys Asn Lys  Ile Gly Gly Leu Val  Ser Tyr Phe 
    1415                 1420                 1425             


Asn Leu  Ser Ser Ile Arg Glu  Gly Tyr Leu Val Gln  Thr Phe Pro 
    1430                 1435                 1440             


Gly Tyr  Gln Pro Thr Pro Gly  Tyr Cys Arg Arg Leu  Gly Leu Asn 
    1445                 1450                 1455             


Thr Ala  Phe His Pro Ile Ser  Thr Glu Asp Leu Thr  Ser Asn Leu 
    1460                 1465                 1470             


Val Tyr  Ser Gln Arg Pro Asn  Lys Glu Thr Thr Thr  Ile Phe Ala 
    1475                 1480                 1485             


Thr Ser  Gly Tyr His Phe His  Gln Asp Asn Lys Glu  Val Gln Leu 
    1490                 1495                 1500             


Asn Glu  Val Val Lys Glu Val  Leu Met Lys Tyr Arg  Gly Ala Lys 
    1505                 1510                 1515             


Lys Phe  Ile Gln Pro Asp Ile  Ile Lys Leu Gly Val  Ser Glu Phe 
    1520                 1525                 1530             


Glu Glu  Gln Phe Lys Lys Leu  Thr Thr Ile Asp Val  Glu Ile Gln 
    1535                 1540                 1545             


Ser Lys  Asn Ile Glu Ser Leu  Ile Lys Leu Thr Asn  Asp Arg Ala 
    1550                 1555                 1560             


Ile Leu  Val Asn Ser Val Thr  Ala Ala Arg Phe Val  Gly Gly Ser 
    1565                 1570                 1575             


Asn Ile  Val Lys Val Ser Ser  Arg Val Arg Ser Asn  Asn Tyr Ser 
    1580                 1585                 1590             


Phe Asn  Pro Leu Asp Phe Ala  Ile Pro Ile Asn Ala  Thr Val Ser 
    1595                 1600                 1605             


Asp Ala  Leu Asp Ile Ala Met  Lys Ser Tyr Arg Leu  Leu Leu Ser 
    1610                 1615                 1620             


Ala Asn  Val Asp Tyr Thr Val  Phe Ile Lys Cys Glu  Glu Phe Ser 
    1625                 1630                 1635             


Cys Ile  Gly Ile Asn Gly Asn  Ile Tyr Tyr Thr Ser  Val Pro Phe 
    1640                 1645                 1650             


Asn Val  Thr Ser Tyr Ser His  Ile Ala Thr Lys Val  Ile Thr Phe 
    1655                 1660                 1665             


Tyr Lys  Val Asp Thr Asn Ser  Asp Gly Ile Thr Asn  Asn Ser Glu 
    1670                 1675                 1680             


Leu Ile  Lys Phe Thr Pro Asp  Glu Tyr Ala Lys Leu  Ile Ile Thr 
    1685                 1690                 1695             


Gly Glu  Gly Glu Gln Lys Leu  Phe Asp Lys Leu Pro  Tyr Ala Ala 
    1700                 1705                 1710             


Cys Lys  Tyr Ile Tyr Gly Ala  Arg Ala Glu Ile Glu  Pro His Phe 
    1715                 1720                 1725             


Ala Thr  Thr Phe Thr Lys Tyr  Glu Val Arg Thr Glu  Val Tyr Asp 
    1730                 1735                 1740             


Asn His  Thr Arg Glu Lys Met  Ala Phe Phe Val Ile  Tyr Ser Glu 
    1745                 1750                 1755             


Phe Lys  Lys Thr Ile Trp Tyr  Lys Ile Ala Ile Gly  Ile Leu Ala 
    1760                 1765                 1770             


Ile Thr  Ala Ser Val Leu Ile  Ile Glu Leu Ile Thr  Gln Ile Trp 
    1775                 1780                 1785             


Asn Met  Phe Ile Gly Leu Lys  Glu Val Phe Thr Ser  Thr Val Gln 
    1790                 1795                 1800             


Lys Asp  Asn Val Lys Val Val  Tyr Gln Val Leu Ser  Val Asn Pro 
    1805                 1810                 1815             


Lys Glu  Gln Ser Ala Glu Val  Lys Val Tyr Gly Phe  Lys Asp Asp 
    1820                 1825                 1830             


Leu Asp  Ser Phe Ser Asn Lys  Glu Leu Ser Asn Leu  Ile Ile Asp 
    1835                 1840                 1845             


Asp Ile  Asp Val Ala Lys Leu  Asp Asp Ser Ile Pro  Ala Asp Thr 
    1850                 1855                 1860             


Val Ile  Lys Ala Leu Asp Met  Ser Gln Met Thr Val  His Ser Asp 
    1865                 1870                 1875             


Trp Asn  Lys Lys Asp Phe Ala  Lys Asn Lys Val Pro  Thr Leu Val 
    1880                 1885                 1890             


His Arg  Met Leu Asp Met Arg  Val His Ser Asp Lys  Ser Gln Asp 
    1895                 1900                 1905             


Asn Lys  Lys Ile Ser Arg Lys  Ala Asn Arg Val Glu  Arg Ile Leu 
    1910                 1915                 1920             


Glu Asn  Met Thr Val Lys Gly  Glu Phe Asp Phe Ile  Lys His Lys 
    1925                 1930                 1935             


Ile Thr  Asn Ser Leu Gly Lys  Val Val Val Ser Ala  Ser Gly Val 
    1940                 1945                 1950             


Val Lys  Thr Val Val Gly Met  Asn Ile Lys Gly His  Tyr Val Ile 
    1955                 1960                 1965             


Cys Pro  Ala His Val Tyr Pro  Val Asp Thr Ala Phe  His Tyr Ala 
    1970                 1975                 1980             


Asn Phe  Thr Pro Phe Asn Thr  Gly Lys Asn Tyr Thr  Met Val Pro 
    1985                 1990                 1995             


Met Val  Cys Ser Arg Val Asp  Asp Leu Ala Leu Phe  Tyr Ile Thr 
    2000                 2005                 2010             


Asp Lys  Leu His Pro Leu Ala  Lys Asp Ile Thr His  His Phe Asp 
    2015                 2020                 2025             


Asp Gln  Glu Arg Leu Tyr Thr  Arg Pro Phe Glu Leu  Pro Tyr Met 
    2030                 2035                 2040             


His Leu  Arg Thr Gly Asn Val  Val Ser Trp Lys Gly  Gly Asp Ala 
    2045                 2050                 2055             


Ile Gly  Leu Arg Ser Leu Val  Thr Lys Val His Gln  Asp Met Leu 
    2060                 2065                 2070             


Leu Thr  Glu Gly Lys Pro Met  Val Ala Gly Gln Phe  Trp Ser Thr 
    2075                 2080                 2085             


Val Thr  Arg Leu Thr Lys Gly  Asp Cys Gly Phe Pro  Ile Ile Asp 
    2090                 2095                 2100             


Thr Asn  Ser His Lys Ile Phe  Ser Ile Tyr Cys Gly  Asp Asn Asn 
    2105                 2110                 2115             


Gly Val  Asn Ala Ile Tyr Gly  Asn Met Val Thr Ser  Thr Leu Val 
    2120                 2125                 2130             


Lys Lys  Met Ile Asp Phe Ala  Glu Gly Val Ser Glu  Val His Ala 
    2135                 2140                 2145             


Phe Thr  Arg Tyr Ser Pro Pro  Met Glu Glu Phe Phe  Asp Ala Glu 
    2150                 2155                 2160             


Asp Thr  Gly Val Met Lys Phe  Ser Tyr Pro Ser Gly  Glu Gln His 
    2165                 2170                 2175             


Ile Val  Met Pro Val Glu Thr  Cys Asp Tyr Ile Ser  Lys Ala Tyr 
    2180                 2185                 2190             


Glu Thr  Glu Asn Tyr Tyr Pro  Cys Met Asp Gly Glu  Phe Thr Arg 
    2195                 2200                 2205             


Asn Ile  Ala Tyr Ser Ser Asp  Cys Gln Lys Asn Ala  Phe Met Lys 
    2210                 2215                 2220             


Pro Lys  Tyr Gln Arg Thr Pro  Phe Ala Glu Glu Ile  Leu Thr Gln 
    2225                 2230                 2235             


Tyr Pro  Gln Ile Lys Asp Asp  Cys Arg Asn Ala Ala  Thr Asp Pro 
    2240                 2245                 2250             


Arg Leu  Val Glu Asp Lys Ser  Lys Leu Val Asn Ser  Val Lys Gly 
    2255                 2260                 2265             


Asp Pro  Ser Ile Val Met Thr  Gln Leu Ala Lys Ile  Asn Asp Pro 
    2270                 2275                 2280             


Ile Asp  Ala Ala Gly Gly Leu  Met Gly Glu Lys Phe  Met Glu Glu 
    2285                 2290                 2295             


Ala Ala  Glu Met Leu Thr Glu  Glu Tyr Ile Asp Leu  Tyr Ser Gly 
    2300                 2305                 2310             


Phe Asp  His Arg Phe Leu Thr  Thr Glu Glu Thr Ile  Asn Gly Ile 
    2315                 2320                 2325             


Ala Ser  Pro Gln Ser Asp Leu  Gln Gly His Leu Glu  Ala Val Asn 
    2330                 2335                 2340             


Arg Asp  Ala Ser Ala Gly His  Trp Cys Met Leu Asn  Gly Tyr His 
    2345                 2350                 2355             


Lys Ile  Ser Asp Leu Leu Glu  Glu Gly Gly Ser Tyr  Pro Ser Gly 
    2360                 2365                 2370             


Gln Leu  Arg Tyr His Phe Lys  Lys Glu Asn Lys Val  Ile Ala Lys 
    2375                 2380                 2385             


Leu Glu  Lys His Ile Ser Gln  Gln Lys Lys Met Trp  Ala Lys Gly 
    2390                 2395                 2400             


Ile Arg  Tyr Glu Gly Leu Thr  Lys Asp Asn Leu Lys  Ala Glu Leu 
    2405                 2410                 2415             


Arg Pro  Phe Glu Lys Val Arg  Ile Gly Lys Thr Arg  Val Phe Glu 
    2420                 2425                 2430             


Ser Phe  Asp Phe Phe Thr Thr  Phe Asn His Arg Gln  Leu Phe Gly 
    2435                 2440                 2445             


Thr Ile  Gln Ala Ala Met Lys  Lys Gln Arg Ala Arg  Gly Thr Cys 
    2450                 2455                 2460             


Gln Ile  Gly Leu Ala Gln Tyr  Asp Phe Thr His Leu  Tyr Asn Arg 
    2465                 2470                 2475             


Leu Leu  Gln Thr Ser Pro Phe  Ala Val His Gly Asp  Phe Glu Ala 
    2480                 2485                 2490             


Trp Asp  Lys His Met Asp Trp  Phe Ser Val Gln Leu  Ala Cys Lys 
    2495                 2500                 2505             


Met Trp  Thr Lys Val Leu Trp  Lys Ser Pro Gln Phe  Gln His Trp 
    2510                 2515                 2520             


Asn Asp  Lys Ile Asn Ala His  Lys Phe Glu Cys Glu  Glu Asn Leu 
    2525                 2530                 2535             


Tyr Leu  Met Leu Glu Thr Ala  Met Phe Ser Asn Val  Tyr Ala Val 
    2540                 2545                 2550             


Thr Leu  Ala Asp Gly His Ile  Ile Val Lys Glu Arg  Ser Gln Cys 
    2555                 2560                 2565             


Ser Gly  Val Val Glu Thr Thr  Thr Leu Asn Ser Thr  Val Asn Asp 
    2570                 2575                 2580             


Ile Lys  Cys Val Ala Val Ile  Leu Tyr Leu Ile Lys  Lys His Asn 
    2585                 2590                 2595             


Val Val  Leu Arg Thr Leu Gly  Ala Ser Glu Ala Asp  Ala Arg Lys 
    2600                 2605                 2610             


Tyr Tyr  Glu Asp Tyr Leu Glu  Thr Leu Glu Leu Ser  Lys Lys Ser 
    2615                 2620                 2625             


Arg Lys  Ala Leu Leu Thr Ser  Lys His Ile Tyr Ser  Pro Ile Ile 
    2630                 2635                 2640             


Pro Asp  Arg Arg Thr Ile Lys  Gln Asn Phe Asp Met  Ile Tyr Tyr 
    2645                 2650                 2655             


Gly Asp  Asp Ile Gly Ile Val  Val Asn Leu Glu Phe  Leu Phe Ile 
    2660                 2665                 2670             


Val Asn  Phe Val Ser Ile Lys  Asn Ala Tyr Lys Tyr  Leu Phe Gly 
    2675                 2680                 2685             


Ile Asn  Leu Asp Ser Pro His  Lys Asp Gly Ser Leu  Val Pro Phe 
    2690                 2695                 2700             


Val Pro  Leu Asn Glu Leu Glu  Phe Val Ser Arg Thr  Phe Asp Tyr 
    2705                 2710                 2715             


His Ser  Asp Thr Arg Thr Val  Tyr Pro Lys Leu Lys  Glu Gln Ser 
    2720                 2725                 2730             


Ile Trp  Arg Leu Leu Phe Trp  Cys Thr Asn Leu Arg  Pro Glu Gln 
    2735                 2740                 2745             


Ile Glu  Ser Asn Met Ile Ala  Met Ala Asn Glu Leu  Phe Leu Tyr 
    2750                 2755                 2760             


Glu Glu  Ser Lys Tyr Arg Leu  Phe Ser Ser Ile Val  Asn Ala Ile 
    2765                 2770                 2775             


Ile Ser  Pro Tyr Leu Lys Arg  Gln Tyr Asn Trp Asn  Leu Ile Leu 
    2780                 2785                 2790             


Pro Ser  Tyr Arg Leu Gly Arg  Val Ala Phe Glu Glu  Met Ser His 
    2795                 2800                 2805             


Glu Leu  Lys Glu Val Pro His  Ser Ser Thr Cys Phe  Thr Glu Leu 
    2810                 2815                 2820             


Glu Ile  His Ser Ile Leu Gln  Lys Ala Gln Asn Ile  Gly Ser Asn 
    2825                 2830                 2835             


<210>  102

<400>  102
000

<210>  103
<211>  663
<212>  RNA
<213>  Western Corn Rootworm

<400>  103
augagcuuuu uuggaaaauu guucgggggg aaaaaggaag agauagcccc uaguccuggg       60

gaggcuauuc aaaaacucag agagacugaa gaaauguuaa uaaaaaaaca ggauuuuuua      120

gaaaagaaga uagaagaauu uaccauggua gcaaagaaaa augcgucgaa aaauaaaaga      180

guugcacucc aagcccucaa aaagaagaaa cgauuggaaa agacccaacu acaaauagau      240

ggaacccuua caacuauuga aaugcagagg gaagcccucg aaggagcuag cacaaauacu      300

gcuguauuag auucuaugaa aaaugcugca gaugcccuua agaaagcuca uaagaauuug      360

aauguagaug auguucacga uaucauggau gacauagccg aacaacacga cauagccaac      420

gaaaucacaa acgcuauuag caauccuguc ggauucaccg acgaucugga ugacgaugaa      480

uuagaaaaag aauuagaaga gcucgaacaa gaaggauugg aagaagaccu gcuccaagug      540

ccagguccaa cucaacugcc ggcugugccu gcugaugcag uugcuacuaa accaaucaaa      600

ccagcagcua aaaaaguuga agaugaugac gauaugaaag aauuggaagc cugggccucg      660

uaa                                                                    663


<210>  104
<211>  2258
<212>  RNA
<213>  Western Corn Rootworm

<400>  104
ggccuucaag cagaauugaa gcuacccguc ucguaguacc cuuagcuugu cuguaccagc       60

cuauaaagga acgucuggau cuuccaccaa uacaauauga cccuguuuua uguacuagaa      120

auacuuguag agcaauauua aacccacugu gucagguaga uuaucgagca aaacucuggg      180

uaugcaacuu uuguuuccag agaaauccau uuccaccuca auaugcugcu auuucagaac      240

aacaucaacc agcggaauug augccuaugu uuuccaccau ugaauacaca auaacuagag      300

cucaauguuu accaccaaua uuuuuguaug uuguugacac cugcauggau gaugaagaac      360

uggguucccu gaaagacuca uugcaaaugu cccuuaguuu guugccaccu aaugcguuaa      420

uaggacuaau aacauuuggg aaaaugguuc aaguucauga acuuggcacu gaagguugua      480

guaagucaua uguguucaga gguacaaaag aucuuagugc uaaacagguu caagaaaugc      540

ugggaauagg caaaguggcu uuaggucagc aagccccuca acagccaggg cagccucuaa      600

gaccugggca aaugcaaccu acuguuguug caccaggaag cagguuucua caaccuguau      660

ccaaaugcga uaugaaucua acagaccuaa uaggagaaca acagaaagau ccuuggccug      720

uucaucaggg uaaaagguau uuaagaucua cagguguagc uuuaucgauu gccauugguu      780

uguuagaaug uacauauucc aauacuggcg cccgaguuau gcuauuuguu ggaggaccuu      840

gcucacaagg accuggucag guaguuaaug augauuuaaa acagccuauu agaucacauc      900

augauauuca gaaagauaau gcaaaauaua ugaagaaagg uauuaaacau uaugaugcgu      960

uagcaaugag agccgcaacu aauggucacu cuguugauau uuauucuugu gcuuuggauc     1020

agacaggucu gauggaaaug aagcaaugcu guaauucuac ugggggacac augguaaugg     1080

gggauucauu uaauucuucc uuguuuaagc aaacuuucca acguguguuu accagagauc     1140

aaaaaaguga ucugaaaaug gcauuuaacg guacuuugga agugaagugu ucccgagaau     1200

uaaaaguuca aggagguauc gguucgugug uaucacuuaa cgugaagagc cccuugguuu     1260

ccgacacaga aauaggaaug gguaauacug ugcaauggaa aauguguacu uuaacgccaa     1320

guacuaccau gucuuuauuc uuugaggucg uaaaucaaca uucugcuccc auaccucaag     1380

gugguagagg uuguauacaa uuuauuacgc aguaccagca uucaaguggu caaagaaaaa     1440

ucagaguaac aacaguggcu cgaaauuggg cugacgcaac ugcuaauaua caccauauca     1500

gugccggauu cgaucaagaa gcugcugcug uaauaauggc uaggauggcc guuuauaggg     1560

cagaaucuga ugauagucca gauguucuua gauggguuga cagaaugcug auuagauugu     1620

gucaaaaauu cggagaauac aauaaggacg accccaauuc auucagacuu ggucaaaacu     1680

ucagucuuua cccacaguuc auguaucacu uaagaagauc ucaauuucuu caaguauuca     1740

auaauucucc ggacgagacu ucauucuaca gacacauguu gaugagggaa gaucuuacuc     1800

aaucuuugau aaugauucaa ccuauuuugu auaguuauag uuucaauggu ccaccagagc     1860

cuguauuacu agauacuagc uccauucaac cugacagaau auuacuuaug gauacuuucu     1920

uccaaauauu aauuuuccau ggagagacua ucgcccaaug gcguaguuua aaauaucaag     1980

acaugccaga auaugaaaac uuuagacagc uacuacaggc uccaguagau gaugcacaag     2040

aaauuuugca aacuagguuc ccaaugccga gauauauuga uaccgaacaa ggcggauccc     2100

aagccagauu uuuguugucg aaaguaaauc caagucaaac ucauaacaac auguauuccu     2160

acggagguga uucuggagcu ccaguuuuga cagaugaugu aucccuucaa guauucaugg     2220

accaucuaaa gaaauuggca guuucgucca cagcauaa                             2258


<210>  105
<211>  1323
<212>  RNA
<213>  Western Corn Rootworm

<400>  105
auaauaaguu cgauuuuuua cgaaaaugac aaguaucgag acugugggga ccauuguccu       60

gaaauugcug aaguugguga ucaauuugau augucucauc uuguaccgaa ccggauauca      120

aggcuacuuc uugggaguag gaggaaccug gaaucuaaac gaagaaaaaa aucccgaugc      180

agaaauugug gcuuccggcg uauucguagg auuuaugauu uacacauucg ucucgcugau      240

cagccuuugc uucgcuagug gagaucacaa aacgacauuc acugauauuc ugaugaauau      300

aguagggauu uuuaugugga uagcugcugg agcuacagcu cuucauuauu ggcuugggua      360

cuuguccgaa uacaaauaca cgacaauaga uucugaacga caaguugguu uggcguuagg      420

agcgaugugu auaauaaaug gagcggucua ucuuguagac ggaguacuuu ccgcaaucuu      480

uauccucaaa gccaaaaugc aauaacuuuc aucguaauau aaauauauuu auuuagguua      540

uauacuuuac uuuaagcagc ucaaguauac cgugacaucc cacucauaca ucaaugucua      600

uaauuguuuc augacaaauc auuuaauagu auuuuaaagc auucauucgu ucaacaccuu      660

uuuuacauuu uucaaguauu auaucaaucu uuuuaaagaa uuguuuggcu auuaaccgga      720

uucaauccau auaguuccgu aaaauaauua ugcguuuuaa uaauuaaugu aauuaaaaau      780

aguuaguaua uuuuugaaau aaaacaacug ccgcaacaaa uuagggagaa uacuuuuguc      840

uccuguaguu uuaucuguua uccaaaguuc gauuaaauug uuucaauuua auguauuuuu      900

ccauauaacg caccaaauag ucuuaaaaaa auagugccug uuacuaccua auacuuucua      960

cguaugccuu augguuagua guggcuccaa uaggugcauu uuacauuuuu caugaaaauu     1020

caauucacau uauuuuccuc ccguucucuu cauauuauau uuauuuauuc uuuaauauag     1080

uuuugggcgu gaagcccagu aaauaccuau augaaguaua uugauggaac ugccaugcuu     1140

gauggguuuu gucugcaauu aaaauaaaac caaaacaaac auuuguacag uauuguaaaa     1200

uucacaauau uuagguagau guuuaaaauu uaauauuuuu uaagaguuug cauuuauguu     1260

aaucguaguu aaguuuuuau aaaaauuuag uaguugugag aaauaaaaua aguaaaagag     1320

aaa                                                                   1323


<210>  106
<211>  34
<212>  RNA
<213>  Human

<400>  106
gggaucaugu ggguccuauu acauuuuaaa ccca                                   34


<210>  107
<211>  5063
<212>  RNA
<213>  Aedes aegypti

<400>  107
ggccauuacg gccggggaau uuguugcgag cacuuguccg aacgccaagu guaacaucgg       60

uuauugaaag gaagugaaaa uauuugcauu uuauuuucgu ugugauaggg gguuuaucgg      120

agaaggauug uuccuuucga gcuuggagug gaaaugaugc aagaaaauag uuucgauuag      180

aagagagcug uuuaacaugu gcuuuagugu ucuuaagaua gaagugauau auugcuagaa      240

aaaaaauccc gaagucagau uccuacaaaa aaaaugaaga acaacgguaa caacuugcaa      300

uacuuuacgg aaucgucuga cgacgaugac gaagaaacgc ugaugaucaa aaaaguucag      360

caggacacca aacuguggga cucguuccga gauccgccgg ugcagcagac guccgguucg      420

gcagccagcc aggauuaucu gagcguguuc aucaaauguc ucaaaguguu uacguacauu      480

uucguguucc ugguaacgcu ggccgccgcg ugccucucca agauguccuu ccugcugaug      540

acgucgaacg ugaaggaggg agucaaaaau agauacugcg augugcgaca accggacaaa      600

caguucgagg ccaucauucc gacagagcaa cgaaucgggu ggaugugggc caucauuauc      660

ucguucacca uuccggaggu uggaacacug auucgagcag cucgcauuug cuucuucaag      720

aacauuccac guccaacguu cggccaguug gcggucguug cccucaugga gggcuuccac      780

gugacggguu uggcuauguu ggcguuccua aucuuuccca auauggacgc uguuaaggcg      840

guaauguuga ccaacugugu cuguuuggug ccggcuauuc ucgggcugcu uucaagauca      900

ucagcggagu cgaagcugcc uuucaaguac accguggaug uguuggccau cagugcccag      960

gugacaggau ucguuguuug gccuuugcug agcaauucgu uugaacugug guuuauuccg     1020

gccgcuguuu uccugguauc augccacugg ugggaaaacu accucucacu uaaaagcuau     1080

uuucgaccau uugccacgcu ggccaccauc cgggagaagc ugacggaaac ucguuacagu     1140

accuaucugu ucguaucacc guucaaagug uugcucuuca uggcagccgg aguguaucua     1200

ucgggccaag cgguuccgga uuuuuucgcc auguucagca acggcugggg aaaccacaca     1260

aucguggucc gugagaugga ggccauccuc aaugagaagu uucccgauuu gagcucgaua     1320

acauccgacc uggaaguguu ggaaauauuc ccggucaaga augcuguucu uuggauuacg     1380

gugacacacg uucugugcuc guacguuugu uacauuuuca guaaauuuuc gugcaaaauc     1440

cacauccaaa gcuuuucgau ggcguuucca aucaaucuga ccguuccggu gacgguuacu     1500

cuccuguugg uguuuugcgg ucuucgagaa gcggacguuu gcguuuucaa cggaauucua     1560

ccggauuauc uauucuuccg gaugccucca auauacuauc uguucgauua ugucgucaac     1620

gaauuuuccu gguugugguu gcuguggcug cugucgcaga ccuggauaac uaggcaucuu     1680

uggaugccga aaagcgaucg caaugcguca acggagaagc ucuucguuac uccaauguac     1740

aauagcuugc ugguggauca gagcgucgcg augaaccgua gacgagaaga ucaagaggau     1800

uucgugaaaa agauagacau ggucaaagug aaggauacgg agaaagcgaa cgaaaucgac     1860

gccaaggcga acgagcgaaa gaacgacacg aucaagccgu acgacaggau uccgcagauc     1920

uucaucugcg ccaccaugug gcacgaaacc aaggaagagu ugauggaauu cuuaaaaucg     1980

auccugcggu uggacgagga ccaaugcgcu cgccggaugg ccaugaagca cauucaggcg     2040

accaaggagg acaucgaucc ggauuauuac gaucuugaga cucacaucuu cuucgacgau     2100

gccuucguca acgacaaauc caagugugaa agcgcuaacg auucuccacu caacuccuau     2160

guaaagacgc uuaucaacaa ccuggaagaa gcggccuugg aaguuuacaa aacuaaaaug     2220

cguaucuauc ccccaaccaa gaucguaacg ccauacggug gccggcucau auggacccuu     2280

cccggacgaa cgaaaaugau agcccaucuc aaggauaaga acaaaauucg ucauaagaaa     2340

cguugguccc agguaaugua cauguacuac cucuugggcu acaggaucau gcagcugaac     2400

accacucccg agcgcaaaau ggugaucgcc cagaacaccu aucuucuggc ccuggauggc     2460

gacaucgauu uucaaccaaa agccgucucc cuucuugugg aucguaugaa aguugauccg     2520

gauuugggug cugccugugg ucguauucau ccgguuggaa ccgguccuau gguuugguac     2580

cagaucuucg aguaugcaau cggucauugg cuucagaaag cuacggagca cgugaucgga     2640

ugcguacuuu guuccccagg augcuucucg cuguuccgag gacgagcucu cauggagaac     2700

uccgucauga agaaguacac caccaagucu gaccaggccc gccacuacgu ccaguacgau     2760

cagggugaag accgauggcu cuguacguug cuucucaagc agaaauuccg aguagaauac     2820

ucggcugccu cggacgcgua uacccaugcu ccggaggggu ucaacgaguu cuacaaccaa     2880

cgucgacguu ggguuccauc uaccauugcc aacaucuucg accuucuugg agaugccaag     2940

cgaguuguca aaaccaacaa uaguauuucg augcccuaua ucgucuacca gagcauguug     3000

auguucggua cgauccucgg cccuggaacg aucuuccuca ugaugguugg ugcuuuaguu     3060

gcuguguuuc guaucgauau cuggacaucg uuccuuugga acggagugcc ccucgcggua     3120

uucauggcca uuugcuucug gaugaagcag aaguaccaac ucauggcggc cuuuuucauc     3180

ucggcuagcu auucgcuggu gaugauggcu gugcugguug guauuguuau ccaggucaug     3240

gaagacggca uccuugcucc aucaucggug uucuucaugg cuguagcguu gcagauuguu     3300

gucacagguc ugcuucaucc ucaggaaaug gaagcccuuc cggcggggcu agucuacuac     3360

aucaccaucc cauccaugua caugauguug gugaucuacu cgguguucaa caugaacgac     3420

guaucguggg gaacccguga gaacccuacg gaagcuccga aggcugcccc agugcaacag     3480

guaccgcagg gcaagaugca caaacugcug ggcuauuugc gaucugggga ccaagaggac     3540

gaaggaucga uuaacuuuuc ugugaguggg cuguucagcu gucuguucug uacucauccg     3600

aaguccagcg cugagaagga gcagauggug caggucgcau ccucgcuggc cgagaucaac     3660

uccaaaauga aggaucugga acugaaauua accggcaccg ucaccguaau gagauccucc     3720

gacgacgacg augacgugga ugagaugagc ugucucgaca ugcaaggcgg aucuccgaac     3780

ggaguguccu ccccgauuca gaccgugaag aacuccgaac uggaagagcc ggaaaagcaa     3840

aucaacuauc uuccggauug gcuuuacgac guagaucugc gaaauggcga caccgaaacc     3900

aucuccgcuu cggaagaaca guucuggauc gaguugaucg aaaaguccuc aaacccugga     3960

ucugacagag aagcagaaag ugagaugcaa ucccagcuga aaaaccuucg ugaucuggcc     4020

guauuugcuu ucgugauggc gaacgcccua uucgugcugg ucaucuuccu gcugcaguug     4080

aacaaaaagg accugcacau ccaguggugg uucaacgcga agaacaccau cagcuucgac     4140

gagagcaccg uggagauuau cguucgccgg gaguucuuaa agaucgaacc uaucggauug     4200

guguucgugu ucuucuucgg guugauccuc gucauccagu ucguugcgau gcugaugcac     4260

cgcuucggga cgaucucgca gaucuuggcg uccacgcagc ugaauuggua cuguucgaag     4320

aaggcgaagg acaugucccu ggaugcggag uugagggaga augccgugga aaucgcaagg     4380

agauugcagc gaccgaagcc acagugggau gaagaagauc uggaagacga ucagaaagcg     4440

auugggagga gagacacgau ccauagaauc cuauaccaac acaagaacaa acaggauugg     4500

agcaaucugg aggcgaacuu caagcgcaac uacuacaagg acggcgaucu gaacuuggga     4560

ggaagauuaa cgcucagucg aaagacacug aauguccugg acacgagaag aaagucgaug     4620

gccgaacaaa ggaaaauucg gaagucgauu cuucgaggac agaaccccua cgacacggcu     4680

ggagauuugu gguaccaggg uagcccagac aguggacuca aucaacggaa aacuucuucu     4740

ccuccagguu acaacggagc ggcaaggggu ccgccuucca aucaaucgcc aaacuucgaa     4800

ggaaacaauc gcgguagggu gaacuacgcu uaucaaaucg acgaagaacu agaggacuac     4860

ucggaggaag aagacacgau ggaguucgaa cguccgacgc ugcaaaugga gaugaccgaa     4920

cgaccgacgc ccaaauccaa aaggaagagu cgaguugcuu uugccuaaac ugaaacauau     4980

cuuguaguua aagauucauu auucccccaa cacaauaaaa aguaacucaa cgaaaaaaaa     5040

aaaaaaaaaa aaaaaaaaaa aaa                                             5063


