                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       The University of Manchester
       Petri, William A. Jr.
       Donlan, Alexandra N.
       Young, Mary Katherine
       Abhyankar, Mayuresh M.
       Mann, Barbara
 
<120>  TYPE 2 CYTOKINES AS PREDICTORS OF DISEASE SEVERITY AND/OR AS 
       THERAPEUTIC TARGETS FOR COVID-19

<130>  3062/131 PCT

<150>  US 63/040,254
<151>  2020-06-17

<150>  US 63/073,234
<151>  2020-09-01

<150>  US 63/129,145
<151>  2020-12-22

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  2
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
1               5                   10                  15      


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
            20                  25                  30          


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
        35                  40                  45              


Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val 
    50                  55                  60                  


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln Phe 
65                  70                  75                  80  


Asn 
    


<210>  3
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  4
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  5
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  6
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu 
1               5                   10                  15      


Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu 
            20                  25                  30          


Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val 
        35                  40                  45              


Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala 
    50                  55                  60                  


Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys 
65                  70                  75                  80  


Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn 
                85                  90                  95      


Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp 
            100                 105                 110         


Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Ser Leu Arg Ala Leu Arg Gln Met 
    130                 135     


<210>  7
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asn Ser Phe Ser Thr Ile Pro Pro Gly Glu Asp Ser Lys Asp Val 
1               5                   10                  15      


Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys 
            20                  25                  30          


Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr 
        35                  40                  45              


Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu 
    50                  55                  60                  


Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln 
65                  70                  75                  80  


Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu 
                85                  90                  95      


Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser 
            100                 105                 110         


Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile 
        115                 120                 125             


Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro 
    130                 135                 140                 


Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn 
145                 150                 155                 160 


Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys 
                165                 170                 175     


Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met 
            180                 185                 


<210>  8
<211>  1283
<212>  DNA
<213>  Homo sapiens

<400>  8
aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg       60

cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc      120

ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac atcacccaga      180

accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca      240

tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga      300

cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct      360

tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt      420

taaagaaact ttttcgcgag ggacagttca actgaaactt cgaaagcatc attatttgca      480

gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc      540

ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct      600

gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg      660

tgggcctcct ctgtccaggg ccctgagctc ggtggaccca gggatgacat gtccctacac      720

ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg      780

tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca      840

cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg      900

gggattgggg aagactgtgg ctgctagcac ttggagccaa gggttcagag actcagggcc      960

ccagcactaa agcagtggac accaggagtc cctggtaata agtactgtgt acagaattct     1020

gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg     1080

cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt     1140

gtttttcctt gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac     1200

cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc     1260

agaaataaag ttggtgacag ata                                             1283


<210>  9
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  9
acgcgcgggg gcgcccctgc ccaccgctcc cggcagggct tttggtggcc atgggggata       60

aggggcgttg actcacccgg gcggggctcc gggagttgca cagaccaagg ccctgtgcct      120

ccctctacag ccctcaggga gctcattgag gagctggtca acatcaccca gaaccagaag      180

gctccgctct gcaatggcag catggtatgg agcatcaacc tgacagctgg catgtactgt      240

gcagccctgg aatccctgat caacgtgtca ggctgcagtg ccatcgagaa gacccagagg      300

atgctgagcg gattctgccc gcacaaggtc tcagctgggc agttttccag cttgcatgtc      360

cgagacacca aaatcgaggt ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa      420

ctttttcgcg agggacagtt caactgaaac ttcgaaagca tcattatttg cagagacagg      480

acctgactat tgaagttgca gattcatttt tctttctgat gtcaaaaatg tcttgggtag      540

gcgggaagga gggttaggga ggggtaaaat tccttagctt agacctcagc ctgtgctgcc      600

cgtcttcagc ctagccgacc tcagccttcc ccttgcccag ggctcagcct ggtgggcctc      660

ctctgtccag ggccctgagc tcggtggacc cagggatgac atgtccctac acccctcccc      720

tgccctagag cacactgtag cattacagtg ggtgcccccc ttgccagaca tgtggtggga      780

cagggaccca cttcacacac aggcaactga ggcagacagc agctcaggca cacttcttct      840

tggtcttatt tattattgtg tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg      900

ggaagactgt ggctgctagc acttggagcc aagggttcag agactcaggg ccccagcact      960

aaagcagtgg acaccaggag tccctggtaa taagtactgt gtacagaatt ctgctacctc     1020

actggggtcc tggggcctcg gagcctcatc cgaggcaggg tcaggagagg ggcagaacag     1080

ccgctcctgt ctgccagcca gcagccagct ctcagccaac gagtaattta ttgtttttcc     1140

ttgtatttaa atattaaata tgttagcaaa gagttaatat atagaagggt accttgaaca     1200

ctgggggagg ggacattgaa caagttgttt cattgactat caaactgaag ccagaaataa     1260

agttggtgac agata                                                      1275


<210>  10
<211>  1454
<212>  DNA
<213>  Homo sapiens

<400>  10
acgcgcgggg gcgcccctgc ccaccgctcc cggcagggct tttggtggcc atgggggata       60

aggggcgttg actcacccgg gcggggctcc gggagttgca cagaccaagg caaatgccgt      120

ggcctctgct gtgggggttt ctggaggact tctaggaaaa cgagggaaga gcaggaaaag      180

gcgacatggc tgcaggggcc aagcccagga gccgccctcc acagcactca ttctgcagaa      240

gggaaatttg aggcccccag acggcagggg ttgatcctgc agagactggc cctgtgcctc      300

cctctacagc cctcagggag ctcattgagg agctggtcaa catcacccag aaccagaagg      360

ctccgctctg caatggcagc atggtatgga gcatcaacct gacagctggc atgtactgtg      420

cagccctgga atccctgatc aacgtgtcag gctgcagtgc catcgagaag acccagagga      480

tgctgagcgg attctgcccg cacaaggtct cagctgggca gttttccagc ttgcatgtcc      540

gagacaccaa aatcgaggtg gcccagtttg taaaggacct gctcttacat ttaaagaaac      600

tttttcgcga gggacagttc aactgaaact tcgaaagcat cattatttgc agagacagga      660

cctgactatt gaagttgcag attcattttt ctttctgatg tcaaaaatgt cttgggtagg      720

cgggaaggag ggttagggag gggtaaaatt ccttagctta gacctcagcc tgtgctgccc      780

gtcttcagcc tagccgacct cagccttccc cttgcccagg gctcagcctg gtgggcctcc      840

tctgtccagg gccctgagct cggtggaccc agggatgaca tgtccctaca cccctcccct      900

gccctagagc acactgtagc attacagtgg gtgcccccct tgccagacat gtggtgggac      960

agggacccac ttcacacaca ggcaactgag gcagacagca gctcaggcac acttcttctt     1020

ggtcttattt attattgtgt gttatttaaa tgagtgtgtt tgtcaccgtt ggggattggg     1080

gaagactgtg gctgctagca cttggagcca agggttcaga gactcagggc cccagcacta     1140

aagcagtgga caccaggagt ccctggtaat aagtactgtg tacagaattc tgctacctca     1200

ctggggtcct ggggcctcgg agcctcatcc gaggcagggt caggagaggg gcagaacagc     1260

cgctcctgtc tgccagccag cagccagctc tcagccaacg agtaatttat tgtttttcct     1320

tgtatttaaa tattaaatat gttagcaaag agttaatata tagaagggta ccttgaacac     1380

tgggggaggg gacattgaac aagttgtttc attgactatc aaactgaagc cagaaataaa     1440

gttggtgaca gata                                                       1454


<210>  11
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  11
acgcgcgggg gcgcccctgc ccaccgctcc cggcagggct tttggtggcc atgggggata       60

aggggcgttg actcacccgg gcggggctcc gggagttgca cagaccaagg caaatgccgt      120

ggcctctgct gtgggggttt ctggaggact tctaggaaaa cgagggaaga gcaggaaaag      180

gcgacatggc tgcaggggcc aagcccagga gccgccctcc acagcactca ttctgcagaa      240

gggaaatttg aggcccccag acggcagggg ttgatcctgc agagactggc tccgctctgc      300

aatggcagca tggtatggag catcaacctg acagctggca tgtactgtgc agccctggaa      360

tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga cccagaggat gctgagcgga      420

ttctgcccgc acaaggtctc agctgggcag ttttccagct tgcatgtccg agacaccaaa      480

atcgaggtgg cccagtttgt aaaggacctg ctcttacatt taaagaaact ttttcgcgag      540

ggacagttca actgaaactt cgaaagcatc attatttgca gagacaggac ctgactattg      600

aagttgcaga ttcatttttc tttctgatgt caaaaatgtc ttgggtaggc gggaaggagg      660

gttagggagg ggtaaaattc cttagcttag acctcagcct gtgctgcccg tcttcagcct      720

agccgacctc agccttcccc ttgcccaggg ctcagcctgg tgggcctcct ctgtccaggg      780

ccctgagctc ggtggaccca gggatgacat gtccctacac ccctcccctg ccctagagca      840

cactgtagca ttacagtggg tgcccccctt gccagacatg tggtgggaca gggacccact      900

tcacacacag gcaactgagg cagacagcag ctcaggcaca cttcttcttg gtcttattta      960

ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg gggattgggg aagactgtgg     1020

ctgctagcac ttggagccaa gggttcagag actcagggcc ccagcactaa agcagtggac     1080

accaggagtc cctggtaata agtactgtgt acagaattct gctacctcac tggggtcctg     1140

gggcctcgga gcctcatccg aggcagggtc aggagagggg cagaacagcc gctcctgtct     1200

gccagccagc agccagctct cagccaacga gtaatttatt gtttttcctt gtatttaaat     1260

attaaatatg ttagcaaaga gttaatatat agaagggtac cttgaacact gggggagggg     1320

acattgaaca agttgtttca ttgactatca aactgaagcc agaaataaag ttggtgacag     1380

ata                                                                   1383


<210>  12
<211>  3996
<212>  DNA
<213>  Homo sapiens

<400>  12
ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg gctctgcggg       60

ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc cgcgcctacg      120

gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg cacagtaata      180

tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta ttttagtcat      240

tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat agaagtaccc      300

ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga gagtgagaag      360

cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga gtctgctgtg      420

actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg gctccctgga      480

aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag cctggaaaaa      540

attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc ctttgatctg      600

accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt caaggataat      660

gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt gaaacctgat      720

cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca atgggagaat      780

ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa cagccaaact      840

gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga atttgagaga      900

aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac tttgaacaca      960

gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact ctggagtaat     1020

tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat aaccatgtta     1080

ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta cctaaaaagg     1140

ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa agaaatgttt     1200

ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga gaagcaaacc     1260

aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc tcagtgatgg     1320

agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt ctccatttgt     1380

tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa caggcagctc     1440

ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat aatgggcgct     1500

ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc ttcaaactag     1560

gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt tgtgacaact     1620

tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa ttttatttgt     1680

aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa gaacatgtag     1740

aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac catgtttgtg     1800

gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct gtaatcccag     1860

caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga ccagcctgac     1920

caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg tggtggcgcg     1980

tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa cctgggaggt     2040

ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac agagcaagac     2100

tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat attctggagt     2160

catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc agtgttggcc     2220

atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt caaagccatt     2280

ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt ttcaaccatg     2340

aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta ctgtgtcttt     2400

ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt acagtctatt     2460

tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt tttcagacct     2520

tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct tcccttcctt     2580

gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga cctggaggag     2640

cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat gactaattct     2700

tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc attttctaaa     2760

cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa aaaagaatag     2820

ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc tctgccataa     2880

atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa ggctctgttt     2940

atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac atatccgtat     3000

atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg agaggcattt     3060

cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa cttgagaact     3120

ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc tatttgcaat     3180

tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt gggtacaagt     3240

ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg aggaagctgg     3300

ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc tgggagacag     3360

ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg gttttcctgt     3420

ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca aaacccatgc     3480

ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg atgctgtgaa     3540

attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa gtgatctttt     3600

gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg aaaaggaagt     3660

tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg aggtgtctgt     3720

atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt tttaggtcta     3780

gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat ggtaattctt     3840

attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata tgtgaaacaa     3900

tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc ttataggaaa     3960

gcttgagtaa aataaatatt gtctttttgt atgtca                               3996


<210>  13
<211>  3624
<212>  DNA
<213>  Homo sapiens

<400>  13
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcagata attaaagatt       60

tacacacagc tggaagaaat catagagaag ccgggcgtgg tggctcatgc ctataatccc      120

agcacttttg gaggctgagg cgggcagatc acttgagatc aggagttcga gaccagcctg      180

gtgccttggc atctcccaat ggggtggctt tgctctgggc tcctgttccc tgtgagctgc      240

ctggtcctgc tgcaggtggc aagctctggg aacatgaagg tcttgcagga gcccacctgc      300

gtctccgact acatgagcat ctctacttgc gagtggaaga tgaatggtcc caccaattgc      360

agcaccgagc tccgcctgtt gtaccagctg gtttttctgc tctccgaagc ccacacgtgt      420

atccctgaga acaacggagg cgcggggtgc gtgtgccacc tgctcatgga tgacgtggtc      480

agtgcggata actatacact ggacctgtgg gctgggcagc agctgctgtg gaagggctcc      540

ttcaagccca gcgagcatgt gaaacccagg gccccaggaa acctgacagt tcacaccaat      600

gtctccgaca ctctgctgct gacctggagc aacccgtatc cccctgacaa ttacctgtat      660

aatcatctca cctatgcagt caacatttgg agtgaaaacg acccggcaga tttcagaatc      720

tataacgtga cctacctaga accctccctc cgcatcgcag ccagcaccct gaagtctggg      780

atttcctaca gggcacgggt gagggcctgg gctcagtgct ataacaccac ctggagtgag      840

tggagcccca gcaccaagtg gcacaactcc tacagggagc ccttcgagca gcacctcctg      900

ctgggcgtca gcgtttcctg cattgtcatc ctggccgtct gcctgttgtg ctatgtcagc      960

atcaccaaga ttaagaaaga atggtgggat cagattccca acccagcccg cagccgcctc     1020

gtggctataa taatccagga tgctcagggg tcacagtggg agaagcggtc ccgaggccag     1080

gaaccagcca agtgcccaca ctggaagaat tgtcttacca agctcttgcc ctgttttctg     1140

gagcacaaca tgaaaaggga tgaagatcct cacaaggctg ccaaagagat gcctttccag     1200

ggctctggaa aatcagcatg gtgcccagtg gagatcagca agacagtcct ctggccagag     1260

agcatcagcg tggtgcgatg tgtggagttg tttgaggccc cggtggagtg tgaggaggag     1320

gaggaggtag aggaagaaaa agggagcttc tgtgcatcgc ctgagagcag cagggatgac     1380

ttccaggagg gaagggaggg cattgtggcc cggctaacag agagcctgtt cctggacctg     1440

ctcggagagg agaatggggg cttttgccag caggacatgg gggagtcatg ccttcttcca     1500

ccttcgggaa gtacgagtgc tcacatgccc tgggatgagt tcccaagtgc agggcccaag     1560

gaggcacctc cctggggcaa ggagcagcct ctccacctgg agccaagtcc tcctgccagc     1620

ccgacccaga gtccagacaa cctgacttgc acagagacgc ccctcgtcat cgcaggcaac     1680

cctgcttacc gcagcttcag caactccctg agccagtcac cgtgtcccag agagctgggt     1740

ccagacccac tgctggccag acacctggag gaagtagaac ccgagatgcc ctgtgtcccc     1800

cagctctctg agccaaccac tgtgccccaa cctgagccag aaacctggga gcagatcctc     1860

cgccgaaatg tcctccagca tggggcagct gcagcccccg tctcggcccc caccagtggc     1920

tatcaggagt ttgtacatgc ggtggagcag ggtggcaccc aggccagtgc ggtggtgggc     1980

ttgggtcccc caggagaggc tggttacaag gccttctcaa gcctgcttgc cagcagtgct     2040

gtgtccccag agaaatgtgg gtttggggct agcagtgggg aagaggggta taagcctttc     2100

caagacctca ttcctggctg ccctggggac cctgccccag tccctgtccc cttgttcacc     2160

tttggactgg acagggagcc acctcgcagt ccgcagagct cacatctccc aagcagctcc     2220

ccagagcacc tgggtctgga gccgggggaa aaggtagagg acatgccaaa gcccccactt     2280

ccccaggagc aggccacaga cccccttgtg gacagcctgg gcagtggcat tgtctactca     2340

gcccttacct gccacctgtg cggccacctg aaacagtgtc atggccagga ggatggtggc     2400

cagacccctg tcatggccag tccttgctgt ggctgctgct gtggagacag gtcctcgccc     2460

cctacaaccc ccctgagggc cccagacccc tctccaggtg gggttccact ggaggccagt     2520

ctgtgtccgg cctccctggc accctcgggc atctcagaga agagtaaatc ctcatcatcc     2580

ttccatcctg cccctggcaa tgctcagagc tcaagccaga cccccaaaat cgtgaacttt     2640

gtctccgtgg gacccacata catgagggtc tcttaggtgc atgtcctctt gttgctgagt     2700

ctgcagatga ggactagggc ttatccatgc ctgggaaatg ccacctcctg gaaggcagcc     2760

aggctggcag atttccaaaa gacttgaaga accatggtat gaaggtgatt ggccccactg     2820

acgttggcct aacactgggc tgcagagact ggaccccgcc cagcattggg ctgggctcgc     2880

cacatcccat gagagtagag ggcactgggt cgccgtgccc cacggcaggc ccctgcagga     2940

aaactgaggc ccttgggcac ctcgacttgt gaacgagttg ttggctgctc cctccacagc     3000

ttctgcagca gactgtccct gttgtaactg cccaaggcat gttttgccca ccagatcatg     3060

gcccacgtgg aggcccacct gcctctgtct cactgaacta gaagccgagc ctagaaacta     3120

acacagccat caagggaatg acttgggcgg ccttgggaaa tcgatgagaa attgaacttc     3180

agggagggtg gtcattgcct agaggtgctc attcatttaa cagagcttcc ttaggttgat     3240

gctggaggca gaatcccggc tgtcaagggg tgttcagtta aggggagcaa cagaggacat     3300

gaaaaattgc tatgactaaa gcagggacaa tttgctgcca aacacccatg cccagctgta     3360

tggctggggg ctcctcgtat gcatggaacc cccagaataa atatgctcag ccaccctgtg     3420

ggccgggcaa tccagacagc aggcataagg caccagttac cctgcatgtt ggcccagacc     3480

tcaggtgcta gggaaggcgg gaaccttggg ttgagtaatg ctcgtctgtg tgttttagtt     3540

tcatcacctg ttatctgtgt ttgctgagga gagtggaaca gaaggggtgg agttttgtat     3600

aaataaagtt tctttgtctc ttta                                            3624


<210>  14
<211>  3491
<212>  DNA
<213>  Homo sapiens

<400>  14
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcaggtg ccttggcatc       60

tcccaatggg gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc      120

aggtggcaag ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca      180

tgagcatctc tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc      240

gcctgttgta ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca      300

acggaggcgc ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact      360

atacactgga cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg      420

agcatgtgaa acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc      480

tgctgctgac ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct      540

atgcagtcaa catttggagt gaaaacgacc cggcagattt cagaatctat aacgtgacct      600

acctagaacc ctccctccgc atcgcagcca gcaccctgaa gtctgggatt tcctacaggg      660

cacgggtgag ggcctgggct cagtgctata acaccacctg gagtgagtgg agccccagca      720

ccaagtggca caactcctac agggagccct tcgagcagca cctcctgctg ggcgtcagcg      780

tttcctgcat tgtcatcctg gccgtctgcc tgttgtgcta tgtcagcatc accaagatta      840

agaaagaatg gtgggatcag attcccaacc cagcccgcag ccgcctcgtg gctataataa      900

tccaggatgc tcaggggtca cagtgggaga agcggtcccg aggccaggaa ccagccaagt      960

gcccacactg gaagaattgt cttaccaagc tcttgccctg ttttctggag cacaacatga     1020

aaagggatga agatcctcac aaggctgcca aagagatgcc tttccagggc tctggaaaat     1080

cagcatggtg cccagtggag atcagcaaga cagtcctctg gccagagagc atcagcgtgg     1140

tgcgatgtgt ggagttgttt gaggccccgg tggagtgtga ggaggaggag gaggtagagg     1200

aagaaaaagg gagcttctgt gcatcgcctg agagcagcag ggatgacttc caggagggaa     1260

gggagggcat tgtggcccgg ctaacagaga gcctgttcct ggacctgctc ggagaggaga     1320

atgggggctt ttgccagcag gacatggggg agtcatgcct tcttccacct tcgggaagta     1380

cgagtgctca catgccctgg gatgagttcc caagtgcagg gcccaaggag gcacctccct     1440

ggggcaagga gcagcctctc cacctggagc caagtcctcc tgccagcccg acccagagtc     1500

cagacaacct gacttgcaca gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca     1560

gcttcagcaa ctccctgagc cagtcaccgt gtcccagaga gctgggtcca gacccactgc     1620

tggccagaca cctggaggaa gtagaacccg agatgccctg tgtcccccag ctctctgagc     1680

caaccactgt gccccaacct gagccagaaa cctgggagca gatcctccgc cgaaatgtcc     1740

tccagcatgg ggcagctgca gcccccgtct cggcccccac cagtggctat caggagtttg     1800

tacatgcggt ggagcagggt ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag     1860

gagaggctgg ttacaaggcc ttctcaagcc tgcttgccag cagtgctgtg tccccagaga     1920

aatgtgggtt tggggctagc agtggggaag aggggtataa gcctttccaa gacctcattc     1980

ctggctgccc tggggaccct gccccagtcc ctgtcccctt gttcaccttt ggactggaca     2040

gggagccacc tcgcagtccg cagagctcac atctcccaag cagctcccca gagcacctgg     2100

gtctggagcc gggggaaaag gtagaggaca tgccaaagcc cccacttccc caggagcagg     2160

ccacagaccc ccttgtggac agcctgggca gtggcattgt ctactcagcc cttacctgcc     2220

acctgtgcgg ccacctgaaa cagtgtcatg gccaggagga tggtggccag acccctgtca     2280

tggccagtcc ttgctgtggc tgctgctgtg gagacaggtc ctcgccccct acaacccccc     2340

tgagggcccc agacccctct ccaggtgggg ttccactgga ggccagtctg tgtccggcct     2400

ccctggcacc ctcgggcatc tcagagaaga gtaaatcctc atcatccttc catcctgccc     2460

ctggcaatgc tcagagctca agccagaccc ccaaaatcgt gaactttgtc tccgtgggac     2520

ccacatacat gagggtctct taggtgcatg tcctcttgtt gctgagtctg cagatgagga     2580

ctagggctta tccatgcctg ggaaatgcca cctcctggaa ggcagccagg ctggcagatt     2640

tccaaaagac ttgaagaacc atggtatgaa ggtgattggc cccactgacg ttggcctaac     2700

actgggctgc agagactgga ccccgcccag cattgggctg ggctcgccac atcccatgag     2760

agtagagggc actgggtcgc cgtgccccac ggcaggcccc tgcaggaaaa ctgaggccct     2820

tgggcacctc gacttgtgaa cgagttgttg gctgctccct ccacagcttc tgcagcagac     2880

tgtccctgtt gtaactgccc aaggcatgtt ttgcccacca gatcatggcc cacgtggagg     2940

cccacctgcc tctgtctcac tgaactagaa gccgagccta gaaactaaca cagccatcaa     3000

gggaatgact tgggcggcct tgggaaatcg atgagaaatt gaacttcagg gagggtggtc     3060

attgcctaga ggtgctcatt catttaacag agcttcctta ggttgatgct ggaggcagaa     3120

tcccggctgt caaggggtgt tcagttaagg ggagcaacag aggacatgaa aaattgctat     3180

gactaaagca gggacaattt gctgccaaac acccatgccc agctgtatgg ctgggggctc     3240

ctcgtatgca tggaaccccc agaataaata tgctcagcca ccctgtgggc cgggcaatcc     3300

agacagcagg cataaggcac cagttaccct gcatgttggc ccagacctca ggtgctaggg     3360

aaggcgggaa ccttgggttg agtaatgctc gtctgtgtgt tttagtttca tcacctgtta     3420

tctgtgtttg ctgaggagag tggaacagaa ggggtggagt tttgtataaa taaagtttct     3480

ttgtctcttt a                                                          3491


<210>  15
<211>  3735
<212>  DNA
<213>  Homo sapiens

<400>  15
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcaggtg ccttggcatc       60

tcccaatggg gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc      120

aggtggcaag ctctggactc ttcaggatgc cgtgtggaga aaggaagagg gtggaagcca      180

ggaggtctgg agggaggtct ggagtggagg agatgagagg ctccggatcc ctctgggagg      240

tagatttgag gacagattgg aattgaggtg aaagacagag aaagagaagt ggccaggatg      300

actccaagat ttctgaccta aactactggg aaggacgcgg ttgtcatttc tgaaatgcag      360

aaggatgcca gaagagaagg gaacatgaag gtcttgcagg agcccacctg cgtctccgac      420

tacatgagca tctctacttg cgagtggaag atgaatggtc ccaccaattg cagcaccgag      480

ctccgcctgt tgtaccagct ggtttttctg ctctccgaag cccacacgtg tatccctgag      540

aacaacggag gcgcggggtg cgtgtgccac ctgctcatgg atgacgtggt cagtgcggat      600

aactatacac tggacctgtg ggctgggcag cagctgctgt ggaagggctc cttcaagccc      660

agcgagcatg tgaaacccag ggccccagga aacctgacag ttcacaccaa tgtctccgac      720

actctgctgc tgacctggag caacccgtat ccccctgaca attacctgta taatcatctc      780

acctatgcag tcaacatttg gagtgaaaac gacccggcag atttcagaat ctataacgtg      840

acctacctag aaccctccct ccgcatcgca gccagcaccc tgaagtctgg gatttcctac      900

agggcacggg tgagggcctg ggctcagtgc tataacacca cctggagtga gtggagcccc      960

agcaccaagt ggcacaactc ctacagggag cccttcgagc agcacctcct gctgggcgtc     1020

agcgtttcct gcattgtcat cctggccgtc tgcctgttgt gctatgtcag catcaccaag     1080

attaagaaag aatggtggga tcagattccc aacccagccc gcagccgcct cgtggctata     1140

ataatccagg atgctcaggg gtcacagtgg gagaagcggt cccgaggcca ggaaccagcc     1200

aagtgcccac actggaagaa ttgtcttacc aagctcttgc cctgttttct ggagcacaac     1260

atgaaaaggg atgaagatcc tcacaaggct gccaaagaga tgcctttcca gggctctgga     1320

aaatcagcat ggtgcccagt ggagatcagc aagacagtcc tctggccaga gagcatcagc     1380

gtggtgcgat gtgtggagtt gtttgaggcc ccggtggagt gtgaggagga ggaggaggta     1440

gaggaagaaa aagggagctt ctgtgcatcg cctgagagca gcagggatga cttccaggag     1500

ggaagggagg gcattgtggc ccggctaaca gagagcctgt tcctggacct gctcggagag     1560

gagaatgggg gcttttgcca gcaggacatg ggggagtcat gccttcttcc accttcggga     1620

agtacgagtg ctcacatgcc ctgggatgag ttcccaagtg cagggcccaa ggaggcacct     1680

ccctggggca aggagcagcc tctccacctg gagccaagtc ctcctgccag cccgacccag     1740

agtccagaca acctgacttg cacagagacg cccctcgtca tcgcaggcaa ccctgcttac     1800

cgcagcttca gcaactccct gagccagtca ccgtgtccca gagagctggg tccagaccca     1860

ctgctggcca gacacctgga ggaagtagaa cccgagatgc cctgtgtccc ccagctctct     1920

gagccaacca ctgtgcccca acctgagcca gaaacctggg agcagatcct ccgccgaaat     1980

gtcctccagc atggggcagc tgcagccccc gtctcggccc ccaccagtgg ctatcaggag     2040

tttgtacatg cggtggagca gggtggcacc caggccagtg cggtggtggg cttgggtccc     2100

ccaggagagg ctggttacaa ggccttctca agcctgcttg ccagcagtgc tgtgtcccca     2160

gagaaatgtg ggtttggggc tagcagtggg gaagaggggt ataagccttt ccaagacctc     2220

attcctggct gccctgggga ccctgcccca gtccctgtcc ccttgttcac ctttggactg     2280

gacagggagc cacctcgcag tccgcagagc tcacatctcc caagcagctc cccagagcac     2340

ctgggtctgg agccggggga aaaggtagag gacatgccaa agcccccact tccccaggag     2400

caggccacag acccccttgt ggacagcctg ggcagtggca ttgtctactc agcccttacc     2460

tgccacctgt gcggccacct gaaacagtgt catggccagg aggatggtgg ccagacccct     2520

gtcatggcca gtccttgctg tggctgctgc tgtggagaca ggtcctcgcc ccctacaacc     2580

cccctgaggg ccccagaccc ctctccaggt ggggttccac tggaggccag tctgtgtccg     2640

gcctccctgg caccctcggg catctcagag aagagtaaat cctcatcatc cttccatcct     2700

gcccctggca atgctcagag ctcaagccag acccccaaaa tcgtgaactt tgtctccgtg     2760

ggacccacat acatgagggt ctcttaggtg catgtcctct tgttgctgag tctgcagatg     2820

aggactaggg cttatccatg cctgggaaat gccacctcct ggaaggcagc caggctggca     2880

gatttccaaa agacttgaag aaccatggta tgaaggtgat tggccccact gacgttggcc     2940

taacactggg ctgcagagac tggaccccgc ccagcattgg gctgggctcg ccacatccca     3000

tgagagtaga gggcactggg tcgccgtgcc ccacggcagg cccctgcagg aaaactgagg     3060

cccttgggca cctcgacttg tgaacgagtt gttggctgct ccctccacag cttctgcagc     3120

agactgtccc tgttgtaact gcccaaggca tgttttgccc accagatcat ggcccacgtg     3180

gaggcccacc tgcctctgtc tcactgaact agaagccgag cctagaaact aacacagcca     3240

tcaagggaat gacttgggcg gccttgggaa atcgatgaga aattgaactt cagggagggt     3300

ggtcattgcc tagaggtgct cattcattta acagagcttc cttaggttga tgctggaggc     3360

agaatcccgg ctgtcaaggg gtgttcagtt aaggggagca acagaggaca tgaaaaattg     3420

ctatgactaa agcagggaca atttgctgcc aaacacccat gcccagctgt atggctgggg     3480

gctcctcgta tgcatggaac ccccagaata aatatgctca gccaccctgt gggccgggca     3540

atccagacag caggcataag gcaccagtta ccctgcatgt tggcccagac ctcaggtgct     3600

agggaaggcg ggaaccttgg gttgagtaat gctcgtctgt gtgttttagt ttcatcacct     3660

gttatctgtg tttgctgagg agagtggaac agaaggggtg gagttttgta taaataaagt     3720

ttctttgtct cttta                                                      3735


<210>  16
<211>  3486
<212>  DNA
<213>  Homo sapiens

<400>  16
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcaggtg ccttggcatc       60

tcccaatggg gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc      120

aggtggcaag ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca      180

tgagcatctc tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc      240

gcctgttgta ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca      300

acggaggcgc ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact      360

atacactgga cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg      420

agcatgtgaa acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc      480

tgctgctgac ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct      540

atgcagtcaa catttggagt gaaaacgacc cggcagataa tctataacgt gacctaccta      600

gaaccctccc tccgcatcgc agccagcacc ctgaagtctg ggatttccta cagggcacgg      660

gtgagggcct gggctcagtg ctataacacc acctggagtg agtggagccc cagcaccaag      720

tggcacaact cctacaggga gcccttcgag cagcacctcc tgctgggcgt cagcgtttcc      780

tgcattgtca tcctggccgt ctgcctgttg tgctatgtca gcatcaccaa gattaagaaa      840

gaatggtggg atcagattcc caacccagcc cgcagccgcc tcgtggctat aataatccag      900

gatgctcagg ggtcacagtg ggagaagcgg tcccgaggcc aggaaccagc caagtgccca      960

cactggaaga attgtcttac caagctcttg ccctgttttc tggagcacaa catgaaaagg     1020

gatgaagatc ctcacaaggc tgccaaagag atgcctttcc agggctctgg aaaatcagca     1080

tggtgcccag tggagatcag caagacagtc ctctggccag agagcatcag cgtggtgcga     1140

tgtgtggagt tgtttgaggc cccggtggag tgtgaggagg aggaggaggt agaggaagaa     1200

aaagggagct tctgtgcatc gcctgagagc agcagggatg acttccagga gggaagggag     1260

ggcattgtgg cccggctaac agagagcctg ttcctggacc tgctcggaga ggagaatggg     1320

ggcttttgcc agcaggacat gggggagtca tgccttcttc caccttcggg aagtacgagt     1380

gctcacatgc cctgggatga gttcccaagt gcagggccca aggaggcacc tccctggggc     1440

aaggagcagc ctctccacct ggagccaagt cctcctgcca gcccgaccca gagtccagac     1500

aacctgactt gcacagagac gcccctcgtc atcgcaggca accctgctta ccgcagcttc     1560

agcaactccc tgagccagtc accgtgtccc agagagctgg gtccagaccc actgctggcc     1620

agacacctgg aggaagtaga acccgagatg ccctgtgtcc cccagctctc tgagccaacc     1680

actgtgcccc aacctgagcc agaaacctgg gagcagatcc tccgccgaaa tgtcctccag     1740

catggggcag ctgcagcccc cgtctcggcc cccaccagtg gctatcagga gtttgtacat     1800

gcggtggagc agggtggcac ccaggccagt gcggtggtgg gcttgggtcc cccaggagag     1860

gctggttaca aggccttctc aagcctgctt gccagcagtg ctgtgtcccc agagaaatgt     1920

gggtttgggg ctagcagtgg ggaagagggg tataagcctt tccaagacct cattcctggc     1980

tgccctgggg accctgcccc agtccctgtc cccttgttca cctttggact ggacagggag     2040

ccacctcgca gtccgcagag ctcacatctc ccaagcagct ccccagagca cctgggtctg     2100

gagccggggg aaaaggtaga ggacatgcca aagcccccac ttccccagga gcaggccaca     2160

gacccccttg tggacagcct gggcagtggc attgtctact cagcccttac ctgccacctg     2220

tgcggccacc tgaaacagtg tcatggccag gaggatggtg gccagacccc tgtcatggcc     2280

agtccttgct gtggctgctg ctgtggagac aggtcctcgc cccctacaac ccccctgagg     2340

gccccagacc cctctccagg tggggttcca ctggaggcca gtctgtgtcc ggcctccctg     2400

gcaccctcgg gcatctcaga gaagagtaaa tcctcatcat ccttccatcc tgcccctggc     2460

aatgctcaga gctcaagcca gacccccaaa atcgtgaact ttgtctccgt gggacccaca     2520

tacatgaggg tctcttaggt gcatgtcctc ttgttgctga gtctgcagat gaggactagg     2580

gcttatccat gcctgggaaa tgccacctcc tggaaggcag ccaggctggc agatttccaa     2640

aagacttgaa gaaccatggt atgaaggtga ttggccccac tgacgttggc ctaacactgg     2700

gctgcagaga ctggaccccg cccagcattg ggctgggctc gccacatccc atgagagtag     2760

agggcactgg gtcgccgtgc cccacggcag gcccctgcag gaaaactgag gcccttgggc     2820

acctcgactt gtgaacgagt tgttggctgc tccctccaca gcttctgcag cagactgtcc     2880

ctgttgtaac tgcccaaggc atgttttgcc caccagatca tggcccacgt ggaggcccac     2940

ctgcctctgt ctcactgaac tagaagccga gcctagaaac taacacagcc atcaagggaa     3000

tgacttgggc ggccttggga aatcgatgag aaattgaact tcagggaggg tggtcattgc     3060

ctagaggtgc tcattcattt aacagagctt ccttaggttg atgctggagg cagaatcccg     3120

gctgtcaagg ggtgttcagt taaggggagc aacagaggac atgaaaaatt gctatgacta     3180

aagcagggac aatttgctgc caaacaccca tgcccagctg tatggctggg ggctcctcgt     3240

atgcatggaa cccccagaat aaatatgctc agccaccctg tgggccgggc aatccagaca     3300

gcaggcataa ggcaccagtt accctgcatg ttggcccaga cctcaggtgc tagggaaggc     3360

gggaaccttg ggttgagtaa tgctcgtctg tgtgttttag tttcatcacc tgttatctgt     3420

gtttgctgag gagagtggaa cagaaggggt ggagttttgt ataaataaag tttctttgtc     3480

tcttta                                                                3486


<210>  17
<211>  1127
<212>  DNA
<213>  Homo sapiens

<400>  17
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca       60

gctatgaact ccttctccac aagcgccttc ggtccagttg ccttctccct ggggctgctc      120

ctggtgttgc ctgctgcctt ccctgcccca gtacccccag gagaagattc caaagatgta      180

gccgccccac acagacagcc actcacctct tcagaacgaa ttgacaaaca aattcggtac      240

atcctcgacg gcatctcagc cctgagaaag gagacatgta acaagagtaa catgtgtgaa      300

agcagcaaag aggcactggc agaaaacaac ctgaaccttc caaagatggc tgaaaaagat      360

ggatgcttcc aatctggatt caatgaggag acttgcctgg tgaaaatcat cactggtctt      420

ttggagtttg aggtatacct agagtacctc cagaacagat ttgagagtag tgaggaacaa      480

gccagagctg tgcagatgag tacaaaagtc ctgatccagt tcctgcagaa aaaggcaaag      540

aatctagatg caataaccac ccctgaccca accacaaatg ccagcctgct gacgaagctg      600

caggcacaga accagtggct gcaggacatg acaactcatc tcattctgcg cagctttaag      660

gagttcctgc agtccagcct gagggctctt cggcaaatgt agcatgggca cctcagattg      720

ttgttgttaa tgggcattcc ttcttctggt cagaaacctg tccactgggc acagaactta      780

tgttgttctc tatggagaac taaaagtatg agcgttagga cactatttta attattttta      840

atttattaat atttaaatat gtgaagctga gttaatttat gtaagtcata tttatatttt      900

taagaagtac cacttgaaac attttatgta ttagttttga aataataatg gaaagtggct      960

atgcagtttg aatatccttt gtttcagagc cagatcattt cttggaaagt gtaggcttac     1020

ctcaaataaa tggctaactt atacatattt ttaaagaaat atttatattg tatttatata     1080

atgtataaat ggtttttata ccaataaatg gcattttaaa aaattca                   1127


<210>  18
<211>  936
<212>  DNA
<213>  Homo sapiens

<400>  18
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca       60

gctatgaact ccttctccac aaacatgtaa caagagtaac atgtgtgaaa gcagcaaaga      120

ggcactggca gaaaacaacc tgaaccttcc aaagatggct gaaaaagatg gatgcttcca      180

atctggattc aatgaggaga cttgcctggt gaaaatcatc actggtcttt tggagtttga      240

ggtataccta gagtacctcc agaacagatt tgagagtagt gaggaacaag ccagagctgt      300

gcagatgagt acaaaagtcc tgatccagtt cctgcagaaa aaggcaaaga atctagatgc      360

aataaccacc cctgacccaa ccacaaatgc cagcctgctg acgaagctgc aggcacagaa      420

ccagtggctg caggacatga caactcatct cattctgcgc agctttaagg agttcctgca      480

gtccagcctg agggctcttc ggcaaatgta gcatgggcac ctcagattgt tgttgttaat      540

gggcattcct tcttctggtc agaaacctgt ccactgggca cagaacttat gttgttctct      600

atggagaact aaaagtatga gcgttaggac actattttaa ttatttttaa tttattaata      660

tttaaatatg tgaagctgag ttaatttatg taagtcatat ttatattttt aagaagtacc      720

acttgaaaca ttttatgtat tagttttgaa ataataatgg aaagtggcta tgcagtttga      780

atatcctttg tttcagagcc agatcatttc ttggaaagtg taggcttacc tcaaataaat      840

ggctaactta tacatatttt taaagaaata tttatattgt atttatataa tgtataaatg      900

gtttttatac caataaatgg cattttaaaa aattca                                936


<210>  19
<211>  1058
<212>  DNA
<213>  Homo sapiens

<400>  19
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca       60

gctatgaact ccttctccac aataccccca ggagaagatt ccaaagatgt agccgcccca      120

cacagacagc cactcacctc ttcagaacga attgacaaac aaattcggta catcctcgac      180

ggcatctcag ccctgagaaa ggagacatgt aacaagagta acatgtgtga aagcagcaaa      240

gaggcactgg cagaaaacaa cctgaacctt ccaaagatgg ctgaaaaaga tggatgcttc      300

caatctggat tcaatgagga gacttgcctg gtgaaaatca tcactggtct tttggagttt      360

gaggtatacc tagagtacct ccagaacaga tttgagagta gtgaggaaca agccagagct      420

gtgcagatga gtacaaaagt cctgatccag ttcctgcaga aaaaggcaaa gaatctagat      480

gcaataacca cccctgaccc aaccacaaat gccagcctgc tgacgaagct gcaggcacag      540

aaccagtggc tgcaggacat gacaactcat ctcattctgc gcagctttaa ggagttcctg      600

cagtccagcc tgagggctct tcggcaaatg tagcatgggc acctcagatt gttgttgtta      660

atgggcattc cttcttctgg tcagaaacct gtccactggg cacagaactt atgttgttct      720

ctatggagaa ctaaaagtat gagcgttagg acactatttt aattattttt aatttattaa      780

tatttaaata tgtgaagctg agttaattta tgtaagtcat atttatattt ttaagaagta      840

ccacttgaaa cattttatgt attagttttg aaataataat ggaaagtggc tatgcagttt      900

gaatatcctt tgtttcagag ccagatcatt tcttggaaag tgtaggctta cctcaaataa      960

atggctaact tatacatatt tttaaagaaa tatttatatt gtatttatat aatgtataaa     1020

tggtttttat accaataaat ggcattttaa aaaattca                             1058


