                         SEQUENCE LISTING

<110>  Arbor Biotechnologies, Inc.
 
<120>  Cells Modified by a Cas12i Polypeptide

<130>  51451-018WO4

<150>  US 63/134,271
<151>  2021-01-06

<150>  US 63/085,687
<151>  2020-09-30

<150>  US 63/063,821
<151>  2020-08-10

<150>  US 63/039,933
<151>  2020-06-16

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  3162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
atgagcagcg cgatcaaaag ctacaagagc gttctgcgtc cgaacgagcg taagaaccaa       60

ctgctgaaaa gcaccattca gtgcctggaa gacggtagcg cgttcttttt caagatgctg      120

caaggcctgt ttggtggcat caccccggag attgttcgtt tcagcaccga acaggagaaa      180

cagcaacagg atatcgcgct gtggtgcgcg gttaactggt tccgtccggt gagccaagac      240

agcctgaccc acaccattgc gagcgataac ctggtggaga agtttgagga atactatggt      300

ggcaccgcga gcgacgcgat caaacagtac ttcagcgcga gcattggcga aagctactat      360

tggaacgact gccgtcaaca gtactatgat ctgtgccgtg agctgggtgt tgaggtgagc      420

gacctgaccc atgatctgga gatcctgtgc cgtgaaaagt gcctggcggt tgcgaccgag      480

agcaaccaga acaacagcat cattagcgtt ctgtttggca ccggcgaaaa agaggaccgt      540

agcgtgaaac tgcgtatcac caagaaaatt ctggaggcga tcagcaacct gaaagaaatc      600

ccgaagaacg ttgcgccgat tcaagagatc attctgaacg tggcgaaagc gaccaaggaa      660

accttccgtc aggtgtatgc gggtaacctg ggtgcgccga gcaccctgga gaaatttatc      720

gcgaaggacg gccaaaaaga gttcgatctg aagaaactgc agaccgacct gaagaaagtt      780

attcgtggta aaagcaagga gcgtgattgg tgctgccagg aagagctgcg tagctacgtg      840

gagcaaaaca ccatccagta tgacctgtgg gcgtggggcg aaatgttcaa caaagcgcac      900

accgcgctga aaatcaagag cacccgtaac tacaactttg cgaagcaacg tctggaacag      960

ttcaaagaga ttcagagcct gaacaacctg ctggttgtga agaagctgaa cgactttttc     1020

gatagcgaat ttttcagcgg cgaggaaacc tacaccatct gcgttcacca tctgggtggc     1080

aaggacctga gcaaactgta taaggcgtgg gaggatgatc cggcggaccc ggaaaacgcg     1140

attgtggttc tgtgcgacga tctgaaaaac aactttaaga aagagccgat ccgtaacatt     1200

ctgcgttaca tcttcaccat tcgtcaagaa tgcagcgcgc aggacatcct ggcggcggcg     1260

aagtacaacc aacagctgga tcgttataaa agccaaaagg cgaacccgag cgttctgggt     1320

aaccagggct ttacctggac caacgcggtg atcctgccgg agaaggcgca gcgtaacgac     1380

cgtccgaaca gcctggatct gcgtatttgg ctgtacctga aactgcgtca cccggacggt     1440

cgttggaaga aacaccatat cccgttctac gatacccgtt tcttccaaga aatttatgcg     1500

gcgggcaaca gcccggttga cacctgccag tttcgtaccc cgcgtttcgg ttatcacctg     1560

ccgaaactga ccgatcagac cgcgatccgt gttaacaaga aacatgtgaa agcggcgaag     1620

accgaggcgc gtattcgtct ggcgatccaa cagggcaccc tgccggtgag caacctgaag     1680

atcaccgaaa ttagcgcgac catcaacagc aaaggtcaag tgcgtattcc ggttaagttt     1740

gacgtgggtc gtcaaaaagg caccctgcag atcggtgacc gtttctgcgg ctacgatcaa     1800

aaccagaccg cgagccacgc gtatagcctg tgggaagtgg ttaaagaggg tcaataccat     1860

aaagagctgg gctgctttgt tcgtttcatc agcagcggtg acatcgtgag cattaccgag     1920

aaccgtggca accaatttga tcagctgagc tatgaaggtc tggcgtaccc gcaatatgcg     1980

gactggcgta agaaagcgag caagttcgtg agcctgtggc agatcaccaa gaaaaacaag     2040

aaaaaggaaa tcgtgaccgt tgaagcgaaa gagaagtttg acgcgatctg caagtaccag     2100

ccgcgtctgt ataaattcaa caaggagtac gcgtatctgc tgcgtgatat tgttcgtggc     2160

aaaagcctgg tggaactgca acagattcgt caagagatct ttcgtttcat tgaacaggac     2220

tgcggtgtta cccgtctggg cagcctgagc ctgagcaccc tggaaaccgt gaaagcggtt     2280

aagggtatca tttacagcta ttttagcacc gcgctgaacg cgagcaagaa caacccgatc     2340

agcgacgaac agcgtaaaga gtttgatccg gaactgttcg cgctgctgga aaagctggag     2400

ctgattcgta cccgtaaaaa gaaacaaaaa gtggaacgta tcgcgaacag cctgattcag     2460

acctgcctgg agaacaacat caagttcatt cgtggtgaag gcgacctgag caccaccaac     2520

aacgcgacca agaaaaaggc gaacagccgt agcatggatt ggttggcgcg tggtgttttt     2580

aacaaaatcc gtcaactggc gccgatgcac aacattaccc tgttcggttg cggcagcctg     2640

tacaccagcc accaggaccc gctggtgcat cgtaacccgg ataaagcgat gaagtgccgt     2700

tgggcggcga tcccggttaa ggacattggc gattgggtgc tgcgtaagct gagccaaaac     2760

ctgcgtgcga aaaacatcgg caccggcgag tactatcacc aaggtgttaa agagttcctg     2820

agccattatg aactgcagga cctggaggaa gagctgctga agtggcgtag cgatcgtaaa     2880

agcaacattc cgtgctgggt gctgcagaac cgtctggcgg agaagctggg caacaaagaa     2940

gcggtggttt acatcccggt tcgtggtggc cgtatttatt ttgcgaccca caaggtggcg     3000

accggtgcgg tgagcatcgt tttcgaccaa aaacaagtgt gggtttgcaa cgcggatcat     3060

gttgcggcgg cgaacatcgc gctgaccgtg aagggtattg gcgaacaaag cagcgacgaa     3120

gagaacccgg atggtagccg tatcaaactg cagctgacca gc                        3162


<210>  2
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  3
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Arg Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  4
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  5
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
tgtcccccca agttttggac                                                   20


<210>  7
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
agaaauccgu cuuucauuga cggugucccc ccaaguuuug gac                         43


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
gcttttgtcc ccccaagttt                                                   20


<210>  9
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
gcuuuugucc ccccaaguuu gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
ggagaggtga gggacttggg                                                   20


<210>  11
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
agaaauccgu cuuucauuga cggggagagg ugagggacuu ggg                         43


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
ggagaggtga gggacttggg                                                   20


<210>  13
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
ggagagguga gggacuuggg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
gtgagaatgg tgcgtcctag                                                   20


<210>  15
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
agaaauccgu cuuucauuga cgggugagaa uggugcgucc uag                         43


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
ttgtgagaat ggtgcgtcct                                                   20


<210>  17
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
uugugagaau ggugcguccu gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
aactggccct ggctttggca                                                   20


<210>  19
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
agaaauccgu cuuucauuga cggaacuggc ccuggcuuug gca                         43


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
gctttaactg gccctggctt                                                   20


<210>  21
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
gcuuuaacug gcccuggcuu gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
ggatggcgac ttcaggcaca                                                   20


<210>  23
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
agaaauccgu cuuucauuga cggggauggc gacuucaggc aca                         43


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
tggatggcga cttcaggcac                                                   20


<210>  25
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
uggauggcga cuucaggcac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
atgtgattga tgcccaaagg                                                   20


<210>  27
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
agaaauccgu cuuucauuga cggaugugau ugaugcccaa agg                         43


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
tttatgtgat tgatgcccaa                                                   20


<210>  29
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
uuuaugugau ugaugcccaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
ggggaggcct ggagtcatgg                                                   20


<210>  31
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
agaaauccgu cuuucauuga cggggggagg ccuggaguca ugg                         43


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
tttggggagg cctggagtca                                                   20


<210>  33
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
uuuggggagg ccuggaguca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
tgggggtgac cgccggagcg                                                   20


<210>  35
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
agaaauccgu cuuucauuga cggugggggu gaccgccgga gcg                         43


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
tgggggtgac cgccggagcg                                                   20


<210>  37
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
ugggggugac cgccggagcg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
gttgacattg tccacacctg                                                   20


<210>  39
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
agaaauccgu cuuucauuga cggguugaca uuguccacac cug                         43


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
ttgttgacat tgtccacacc                                                   20


<210>  41
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
uuguugacau uguccacacc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
ggaaatctat tgaggctctg                                                   20


<210>  43
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
agaaauccgu cuuucauuga cggggaaauc uauugaggcu cug                         43


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
ttggaaatct attgaggctc                                                   20


<210>  45
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
uuggaaaucu auugaggcuc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcuuuu uu                         102


<210>  46
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  47
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg 
    610                 615                 620                 


Cys Arg Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Arg  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  48
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg 
    610                 615                 620                 


Cys Arg Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Thr Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Arg  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  49
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
agaaauccgu cuuucauuga cggaaugucg gauggaugaa acc                         43


<210>  50
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
agaaauccgu cuuucauuga cggcuaucuc uuguacuaca cug                         43


<210>  51
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
agaaauccgu cuuucauuga cggacacggc aggcauacuc auc                         43


<210>  52
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
agaaauccgu cuuucauuga cgggucacag cccaagauag uua                         43


<210>  53
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  gm

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  The linkage between nucleotides at positions 1, 2, 3, and 4 are 
       phosphorothioate linkages

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  um

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  The linkage between nucleotides at positions 97, 98, 99, and 100 
       are phosphorothioate linkages

<400>  53
ggccgagaug ucucgcuccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  54
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
agaaauccgu cuuucauuga cggaagagca acagugcugu ggc                         43


<210>  55
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55
agaaauccgu cuuucauuga cggaacaaca gcauuauucc aga                         43


<210>  56
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
agaaauccgu cuuucauuga cgggaaacag guaagacagg ggu                         43


<210>  57
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57
agaaauccgu cuuucauuga cggcaggagg aggauucgga acc                         43


<210>  58
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  The linkage between nucleotides at positions 1, 2, 3, and 4 are 
       phosphorothioate linkages

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  um

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  The linkage between nucleotides at positions 97, 98, 99, and 100 
       are phosphorothioate linkages

<400>  58
aaguuccugu gaugucaagc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  59
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59
agaaauccgu cuuucauuga cgguuaggua gguggggucg gcg                         43


<210>  60
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
agaaauccgu cuuucauuga cggcccgagg accgcagcca gcc                         43


<210>  61
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
agaaauccgu cuuucauuga cggcguguca cacaacugcc caa                         43


<210>  62
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
agaaauccgu cuuucauuga cggcacauga gcguggucag ggc                         43


<210>  63
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  The linkage between nucleotides at positions 1, 2, 3, and 4 are 
       phosphorothioate linkages

<220>
<221>  modified_base
<222>  (2)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  um

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  The linkage between nucleotides at positions 97, 98, 99, and 100 
       are phosphorothioate linkages

<400>  63
uccaggcaug cagaucccac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  64
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64
agaaauccgu cuuucauuga cgggaagcua gucuagugca agc                         43


<210>  65
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65
agaaauccgu cuuucauuga cggcuggagc cugugauaaa agc                         43


<210>  66
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66
agaaauccgu cuuucauuga cgguacccca cccacgcccc cac                         43


<210>  67
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  cm

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  The linkage between nucleotides at positions 1, 2, 3, and 4 are 
       phosphorothioate linkages

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (97)..(99)
<223>  um

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  The linkage between nucleotides at positions 97, 98, 99, and 100 
       are phosphorothioate linkages

<400>  67
cuaacaguug cuuuuaucac guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


