                         SEQUENCE LISTING

<110>  The Trutees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF GENE THERAPY PATIENTS

<130>  UPN-20-9394.PCT

<150>  US 63/040,381
<151>  2020-06-17

<150>  US 63/152,085
<151>  2021-02-22

<150>  US 63/135,998
<151>  2021-01-11

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  6742
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M281-LC expression plasmid


<220>
<221>  promoter
<222>  (47)..(726)
<223>  CMV Promoter

<220>
<221>  CDS
<222>  (754)..(1467)
<223>  M281_LC

<220>
<221>  misc_feature
<222>  (1514)..(2111)
<223>  WRPE

<220>
<221>  misc_feature
<222>  (2115)..(2386)
<223>  TK pA signal

<220>
<221>  promoter
<222>  (2855)..(3224)
<223>  SV40 early promoter

<220>
<221>  misc_feature
<222>  (3260)..(4054)
<223>  Neo-R

<220>
<221>  polyA_signal
<222>  (4230)..(4360)
<223>  SV40 pA signal

<220>
<221>  rep_origin
<222>  (4743)..(5416)
<223>  pUC ori

<220>
<221>  misc_feature
<222>  (5561)..(6421)
<223>  Amp-R

<220>
<221>  promoter
<222>  (6422)..(6520)
<223>  bla promoter

<400>  1
gttaggcgtt ttgcgctgct tcgcgatgta cgggccagat atacgcgttg acattgatta       60

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag      120

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc      180

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga      240

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      300

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      360

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      420

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca      480

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat      540

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg      600

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg      660

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctccgg      720

actctagagg atcgaaccct tggatccgcc acc atg gaa acc gat aca ctg ctg       774
                                     Met Glu Thr Asp Thr Leu Leu          
                                     1               5                    

ctg tgg gtg ctg ttg ctc tgg gtg cca gga tct aca ggc cag tct gct        822
Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Gln Ser Ala           
        10                  15                  20                        

ctg act cag cct gcc tct gtt tct ggc tcc cct ggc cag tct atc acc        870
Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr           
    25                  30                  35                            

atc tct tgt acc ggc acc ggc tcc gac gtg ggc tct tat aac ctg gtg        918
Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr Asn Leu Val           
40                  45                  50                  55            

tcc tgg tat cag cag cac ccc gga aag gcc cct aag ctg atg atc tac        966
Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr           
                60                  65                  70                

ggc gac tct gaa cgg cct tcc ggc gtg tcc aat aga ttc tcc ggc tcc       1014
Gly Asp Ser Glu Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser           
            75                  80                  85                    

aag tcc ggc aat acc gcc tct ctg aca atc agt gga ctg cag gcc gag       1062
Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu           
        90                  95                  100                       

gac gag gcc gac tac tac tgt tct tct tac gcc ggc tcc ggc atc tac       1110
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Gly Ile Tyr           
    105                 110                 115                           

gtg ttc ggc acc gga aca aaa gtg acc gtg ctg gga cag cct aag gcc       1158
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala           
120                 125                 130                 135           

gct cct tct gtg acc ctg ttt cct cca tcc tcc gag gaa ctg cag gct       1206
Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala           
                140                 145                 150               

aac aag gct acc ctc gtg tgc ctg atc tcc gat ttt tac cct ggc gct       1254
Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala           
            155                 160                 165                   

gtg acc gtg gcc tgg aag gct gat agt tct cct gtg aag gcc ggc gtg       1302
Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val           
        170                 175                 180                       

gaa acc acc aca cct tcc aag cag tcc aac aac aaa tac gcc gcc tcc       1350
Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser           
    185                 190                 195                           

tcc tac ctg tct ctg acc cct gaa cag tgg aag tcc cac aag tcc tac       1398
Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr           
200                 205                 210                 215           

agc tgc caa gtg acc cat gag ggc tcc acc gtg gaa aag aca gtg gcc       1446
Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala           
                220                 225                 230               

cct acc gag tgc tcc tga tga ctcgagaagg gttcgatccc taccggttag          1497
Pro Thr Glu Cys Ser                                                       
            235                                                           

taatgagttt gatatctcga caatcaacct ctggattaca aaatttgtga aagattgact     1557

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     1617

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg     1677

ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg     1737

tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg     1797

actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc     1857

tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg     1917

acgtcctttc catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc     1977

tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct     2037

ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc     2097

gcctccccgc ctggaacggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg     2157

aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg     2217

ttcataaacg cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagacccc     2277

attggggcca atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg     2337

aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc tgccatagca gatctgcgca     2397

gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg     2457

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg     2517

ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg     2577

ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt     2637

agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt     2697

tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta     2757

tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa     2817

atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg     2877

gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta     2937

gtcagcaacc aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat     2997

gcatctcaat tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac     3057

tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga     3117

ggccgaggcc gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg     3177

cctaggcttt tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcaaga     3237

gacaggatga ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc     3297

cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga     3357

tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct     3417

gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac     3477

gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct     3537

attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt     3597

atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt     3657

cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt     3717

cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag     3777

gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt     3837

gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg     3897

tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg     3957

cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg     4017

catcgccttc tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgcgaaa     4077

tgaccgacca agcgacgccc aacctgccat cacgagattt cgattccacc gccgccttct     4137

atgaaaggtt gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg     4197

gggatctcat gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt     4257

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     4317

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta     4377

gctagagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca     4437

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag     4497

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt     4557

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     4617

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     4677

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     4737

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     4797

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     4857

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     4917

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     4977

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     5037

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     5097

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     5157

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     5217

ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag     5277

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     5337

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     5397

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     5457

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     5517

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca     5577

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg     5637

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac     5697

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg     5757

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc     5817

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta     5877

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac     5937

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc     5997

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac     6057

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact     6117

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa     6177

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt     6237

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca     6297

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa     6357

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac     6417

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     6477

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     6537

gaaaagtgcc acctgacgtc gacggatcgg gagatctccc gatcccctat ggtcgactct     6597

cagtacaatc tgctctgatg ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt     6657

ggaggtcgct gagtagtgcg cgagcaaaat ttaagctaca acaaggcaag gcttgaccga     6717

caattgcatg aagaatctgc ttagg                                           6742


<210>  2
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp 
        35                  40                  45              


Val Gly Ser Tyr Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Met Ile Tyr Gly Asp Ser Glu Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Ala Gly Ser Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  3
<211>  7429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M281-HC expression plasmid


<220>
<221>  promoter
<222>  (47)..(726)
<223>  CMV promoter

<220>
<221>  CDS
<222>  (754)..(2154)
<223>  M281_HC

<220>
<221>  misc_feature
<222>  (2201)..(2798)
<223>  WRPE

<220>
<221>  misc_feature
<222>  (2802)..(3073)
<223>  TK pA signal

<220>
<221>  promoter
<222>  (3542)..(3911)
<223>  SV40 ealry promoter

<220>
<221>  misc_feature
<222>  (3947)..(4741)
<223>  Neo-R

<220>
<221>  polyA_signal
<222>  (4917)..(5047)
<223>  SV40 pA signal

<220>
<221>  rep_origin
<222>  (5430)..(6103)
<223>  pUC ori

<220>
<221>  misc_feature
<222>  (6248)..(7108)
<223>  Amp-R

<220>
<221>  promoter
<222>  (7109)..(7207)
<223>  bla promoter

<400>  3
gttaggcgtt ttgcgctgct tcgcgatgta cgggccagat atacgcgttg acattgatta       60

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag      120

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc      180

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga      240

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      300

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      360

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      420

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca      480

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat      540

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg      600

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg      660

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctccgg      720

actctagagg atcgaaccct tggatccgcc acc atg gaa acc gat aca ctg ctg       774
                                     Met Glu Thr Asp Thr Leu Leu          
                                     1               5                    

ctg tgg gtg ctg ttg ctc tgg gtt cca gga tct aca ggc gag gtg cag        822
Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln           
        10                  15                  20                        

ctg ttg gaa tct ggc gga gga ttg gtt cag cct ggc ggc tct ctg aga        870
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg           
    25                  30                  35                            

ctg tct tgt gct gcc tct ggc ttc acc ttc tct acc tac gct atg ggc        918
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Ala Met Gly           
40                  45                  50                  55            

tgg gtc cga cag gct cct gga aaa gga ctg gaa tgg gtg tcc tct atc        966
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile           
                60                  65                  70                

ggc gcc tct ggc agc cag acc aga tac gct gat tcc gtg aag ggc aga       1014
Gly Ala Ser Gly Ser Gln Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg           
            75                  80                  85                    

ttc acc atc agc cgg gac aac tcc aag aac acc ctg tac ctg cag atg       1062
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met           
        90                  95                  100                       

aac tcc ctg aga gcc gag gac acc gcc gtg tac tat tgt gct aga ctg       1110
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu           
    105                 110                 115                           

gcc atc ggc gac tct tat tgg ggc cag gga aca atg gtc acc gtg tcc       1158
Ala Ile Gly Asp Ser Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser           
120                 125                 130                 135           

tct gct tcc acc aag gga cct tcc gtg ttt cct ctg gct cct tcc agc       1206
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser           
                140                 145                 150               

aag tct acc tct ggt gga acc gct gct ctg ggc tgc ctg gtc aag gat       1254
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp           
            155                 160                 165                   

tac ttt cct gag cct gtg acc gtg tct tgg aac tcc ggt gct ctg aca       1302
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr           
        170                 175                 180                       

tcc ggc gtg cac aca ttt cca gct gtg ctg cag tcc tcc ggc ctg tac       1350
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr           
    185                 190                 195                           

tct ctg tcc tct gtc gtg acc gtg cct tct agc tct ctg ggc acc cag       1398
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln           
200                 205                 210                 215           

acc tac atc tgc aac gtg aac cac aag cct tcc aac acc aag gtg gac       1446
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp           
                220                 225                 230               

aag aag gtg gaa ccc aag tcc tgc gac aag acc cac acc tgt cct cca       1494
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro           
            235                 240                 245                   

tgt cct gct cca gaa ctg ctc ggc gga ccc tct gtg ttc ctg ttt cca       1542
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro           
        250                 255                 260                       

cct aag cct aag gac acc ctg atg atc tct cgg acc cct gaa gtg acc       1590
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr           
    265                 270                 275                           

tgc gtg gtg gtg gat gtg tct cac gag gac cca gaa gtg aag ttc aat       1638
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn           
280                 285                 290                 295           

tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga       1686
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg           
                300                 305                 310               

gag gaa cag tac gcc tcc acc tac aga gtg gtg tct gtg ctg acc gtg       1734
Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val           
            315                 320                 325                   

ctg cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc       1782
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser           
        330                 335                 340                       

aac aag gcc ctg cct gct cct atc gaa aag acc atc tcc aag gct aag       1830
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys           
    345                 350                 355                           

ggc cag cct cgg gaa cct cag gtt tac acc ctg cct cca tct cgg gaa       1878
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu           
360                 365                 370                 375           

gag atg acc aag aac cag gtg tcc ctg acc tgc ctc gtg aag gga ttc       1926
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe           
                380                 385                 390               

tac cct tcc gat atc gcc gtg gaa tgg gag tct aac ggc cag cca gag       1974
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
            395                 400                 405                   

aac aac tac aag aca acc cct cct gtg ctg gac tcc gac ggc tca ttc       2022
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
        410                 415                 420                       

ttc ctg tac tcc aag ctg aca gtg gac aag tct cgg tgg cag cag ggc       2070
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
    425                 430                 435                           

aac gtg ttc tcc tgt tct gtg atg cac gag gcc ctg cac aac cac tac       2118
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
440                 445                 450                 455           

aca cag aag tcc ctg tct ctg tcc cct ggc tga tga ctcgagaagg            2164
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                                   
                460                 465                                   

gttcgatccc taccggttag taatgagttt gatatctcga caatcaacct ctggattaca     2224

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     2284

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     2344

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     2404

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     2464

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     2524

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     2584

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga     2644

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     2704

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     2764

gtcggatctc cctttgggcc gcctccccgc ctggaacggg ggaggctaac tgaaacacgg     2824

aaggagacaa taccggaagg aacccgcgct atgacggcaa taaaaagaca gaataaaacg     2884

cacgggtgtt gggtcgtttg ttcataaacg cggggttcgg tcccagggct ggcactctgt     2944

cgatacccca ccgagacccc attggggcca atacgcccgc gtttcttcct tttccccacc     3004

ccacccccca agttcgggtg aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc     3064

tgccatagca gatctgcgca gctggggctc tagggggtat ccccacgcgc cctgtagcgg     3124

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     3184

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     3244

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     3304

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac     3364

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     3424

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat     3484

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attaattctg     3544

tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg cagaagtatg     3604

caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg ctccccagca     3664

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc gcccctaact     3724

ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta     3784

atttttttta tttatgcaga ggccgaggcc gcctctgcct ctgagctatt ccagaagtag     3844

tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tcccgggagc ttgtatatcc     3904

attttcggat ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga     3964

ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa     4024

cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt     4084

ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg     4144

ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa     4204

gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac     4264

cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt     4324

gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact     4384

cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg     4444

ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg     4504

acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc     4564

atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt     4624

gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc     4684

gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagcg     4744

ggactctggg gttcgcgaaa tgaccgacca agcgacgccc aacctgccat cacgagattt     4804

cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc gggacgccgg     4864

ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc ccaacttgtt     4924

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc     4984

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt     5044

ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc tgtttcctgt     5104

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     5164

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     5224

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     5284

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     5344

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     5404

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     5464

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     5524

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     5584

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     5644

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     5704

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     5764

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     5824

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     5884

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     5944

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     6004

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     6064

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     6124

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     6184

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     6244

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     6304

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     6364

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     6424

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     6484

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     6544

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     6604

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     6664

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     6724

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     6784

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     6844

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     6904

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     6964

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     7024

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     7084

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     7144

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     7204

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc gacggatcgg gagatctccc     7264

gatcccctat ggtcgactct cagtacaatc tgctctgatg ccgcatagtt aagccagtat     7324

ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg cgagcaaaat ttaagctaca     7384

acaaggcaag gcttgaccga caattgcatg aagaatctgc ttagg                     7429


<210>  4
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Thr Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ser Ile Gly Ala Ser Gly Ser Gln Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Leu Ala Ile Gly Asp Ser Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  5
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M281_LC nucleic acid sequence

<400>  5
atggaaaccg atacactgct gctgtgggtg ctgttgctct gggtgccagg atctacaggc       60

cagtctgctc tgactcagcc tgcctctgtt tctggctccc ctggccagtc tatcaccatc      120

tcttgtaccg gcaccggctc cgacgtgggc tcttataacc tggtgtcctg gtatcagcag      180

caccccggaa aggcccctaa gctgatgatc tacggcgact ctgaacggcc ttccggcgtg      240

tccaatagat tctccggctc caagtccggc aataccgcct ctctgacaat cagtggactg      300

caggccgagg acgaggccga ctactactgt tcttcttacg ccggctccgg catctacgtg      360

ttcggcaccg gaacaaaagt gaccgtgctg ggacagccta aggccgctcc ttctgtgacc      420

ctgtttcctc catcctccga ggaactgcag gctaacaagg ctaccctcgt gtgcctgatc      480

tccgattttt accctggcgc tgtgaccgtg gcctggaagg ctgatagttc tcctgtgaag      540

gccggcgtgg aaaccaccac accttccaag cagtccaaca acaaatacgc cgcctcctcc      600

tacctgtctc tgacccctga acagtggaag tcccacaagt cctacagctg ccaagtgacc      660

catgagggct ccaccgtgga aaagacagtg gcccctaccg agtgctcctg atgactcgag      720


<210>  6
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M281_HC nucleic acid sequence

<400>  6
atggaaaccg atacactgct gctgtgggtg ctgttgctct gggttccagg atctacaggc       60

gaggtgcagc tgttggaatc tggcggagga ttggttcagc ctggcggctc tctgagactg      120

tcttgtgctg cctctggctt caccttctct acctacgcta tgggctgggt ccgacaggct      180

cctggaaaag gactggaatg ggtgtcctct atcggcgcct ctggcagcca gaccagatac      240

gctgattccg tgaagggcag attcaccatc agccgggaca actccaagaa caccctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc tagactggcc      360

atcggcgact cttattgggg ccagggaaca atggtcaccg tgtcctctgc ttccaccaag      420

ggaccttccg tgtttcctct ggctccttcc agcaagtcta cctctggtgg aaccgctgct      480

ctgggctgcc tggtcaagga ttactttcct gagcctgtga ccgtgtcttg gaactccggt      540

gctctgacat ccggcgtgca cacatttcca gctgtgctgc agtcctccgg cctgtactct      600

ctgtcctctg tcgtgaccgt gccttctagc tctctgggca cccagaccta catctgcaac      660

gtgaaccaca agccttccaa caccaaggtg gacaagaagg tggaacccaa gtcctgcgac      720

aagacccaca cctgtcctcc atgtcctgct ccagaactgc tcggcggacc ctctgtgttc      780

ctgtttccac ctaagcctaa ggacaccctg atgatctctc ggacccctga agtgacctgc      840

gtggtggtgg atgtgtctca cgaggaccca gaagtgaagt tcaattggta cgtggacggc      900

gtggaagtgc acaacgccaa gaccaagcct agagaggaac agtacgcctc cacctacaga      960

gtggtgtctg tgctgaccgt gctgcaccag gattggctga acggcaaaga gtacaagtgc     1020

aaggtgtcca acaaggccct gcctgctcct atcgaaaaga ccatctccaa ggctaagggc     1080

cagcctcggg aacctcaggt ttacaccctg cctccatctc gggaagagat gaccaagaac     1140

caggtgtccc tgacctgcct cgtgaaggga ttctaccctt ccgatatcgc cgtggaatgg     1200

gagtctaacg gccagccaga gaacaactac aagacaaccc ctcctgtgct ggactccgac     1260

ggctcattct tcctgtactc caagctgaca gtggacaagt ctcggtggca gcagggcaac     1320

gtgttctcct gttctgtgat gcacgaggcc ctgcacaacc actacacaca gaagtccctg     1380

tctctgtccc ctggctgatg actcgag                                         1407


<210>  7
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M281_LC amino acid sequence

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp 
        35                  40                  45              


Val Gly Ser Tyr Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Met Ile Tyr Gly Asp Ser Glu Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         


Tyr Ala Gly Ser Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  8
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M281_HC amino acid sequence

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Thr Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ser Ile Gly Ala Ser Gly Ser Gln Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Leu Ala Ile Gly Asp Ser Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  9
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L1 nucleic acid sequence

<400>  9
accggcaccg gctccgacgt gggctcttat aacctggtgt cc                          42


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 amino acid sequence

<400>  10

Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 
1               5                   10                  


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L2 nucleic acid sequence

<400>  11
ggcgactctg aacggccttc c                                                 21


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 amino acid sequence

<400>  12

Gly Asp Ser Glu Arg Pro Ser 
1               5           


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-L3 nucleic acid sequence

<400>  13
tcttcttacg ccggctccgg catctacgtg                                        30


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 amino acid sequence

<400>  14

Ser Ser Tyr Ala Gly Ser Gly Ile Tyr Val 
1               5                   10  


<210>  15
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H1 nucleic acid sequence

<400>  15
acctacgcta tgggc                                                        15


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 amino acid sequence

<400>  16

Thr Tyr Ala Met Gly 
1               5   


<210>  17
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H2 nucleic acid sequence

<400>  17
tctatcggcg cctctggcag ccagaccaga tacgctgatt cc                          42


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 amino acid sequence

<400>  18

Ser Ile Gly Ala Ser Gly Ser Gln Thr Arg Tyr Ala Asp Ser 
1               5                   10                  


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR-H3 nucleic acid sequence

<400>  19
ctggccatcg gcgactctta t                                                 21


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 amino acid sequence

<400>  20

Leu Ala Ile Gly Asp Ser Tyr 
1               5           


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1variant 1

<400>  21

Asp Tyr Ala Met Gly 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 variant 2

<400>  22

Asn Tyr Ala Met Gly 
1               5   


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 variant 1

<400>  23

Ser Ile Gly Ala Ser Gly Ala Gln Thr Arg Tyr Ala Asp Ser 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 variant 2

<400>  24

Ser Ile Gly Ala Ser Gly Gly Gln Thr Arg Tyr Ala Asp Ser 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 variant 3

<400>  25

Ser Ile Gly Ser Ser Gly Ala Gln Thr Arg Tyr Ala Asp Ser 
1               5                   10                  


<210>  26
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z_FcRn-2

<400>  26

Val Asp Ala Lys Tyr Ala Lys Glu Gln Asp Ala Ala Ala His Glu Ile 
1               5                   10                  15      


Arg Trp Leu Pro Asn Leu Thr Phe Asp Gln Arg Val Ala Phe Ile His 
            20                  25                  30          


Lys Leu Ala Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  27
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z_FcRn-4

<400>  27

Val Asp Ala Lys Tyr Ala Lys Glu Trp Met Arg Ala Ala His Glu Ile 
1               5                   10                  15      


Arg Trp Leu Pro Asn Leu Thr Phe Asp Gln Arg Val Ala Phe Ile His 
            20                  25                  30          


Lys Leu Glu Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  28
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Z_FcRn-16

<400>  28

Val Asp Ala Lys Tyr Ala Lys Glu Phe Glu Ser Ala Ala His Glu Ile 
1               5                   10                  15      


Arg Trp Leu Pro Asn Leu Thr Tyr Asp Gln Arg Val Ala Phe Ile His 
            20                  25                  30          


Lys Leu Ser Asp Asp Pro Ser Gln Ser Ser Glu Leu Leu Ser Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYN746

<400>  29

Arg Phe Thr Gly His Phe Gly Leu Tyr Pro Cys 
1               5                   10      


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYN1327

<400>  30

Arg Phe Cys Thr Gly His Phe Gly Gly Leu Tyr Pro Cys 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYN1327-modified


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Pen

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Sar

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  NMeLeu

<400>  31

Arg Phe Xaa Thr Gly His Phe Gly Xaa Leu Tyr Pro Cys 
1               5                   10              


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  98420-1 amino acid sequence

<400>  32

Gln Arg Phe Cys Thr Gly His Phe Gly Gly Leu Tyr Pro Cys Asn Gly 
1               5                   10                  15      


Pro 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  98420-2

<400>  33

Gly Gly Gly Cys Val Thr Gly His Phe Gly Gly Ile Tyr Cys Asn Tyr 
1               5                   10                  15      


Gln 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  98420-3

<400>  34

Lys Ile Ile Cys Ser Pro Gly His Phe Gly Gly Met Tyr Cys Gln Gly 
1               5                   10                  15      


Lys 
    


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  98420-4

<400>  35

Pro Ser Tyr Cys Ile Glu Gly His Ile Asp Gly Ile Tyr Cys Phe Asn 
1               5                   10                  15      


Ala 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  98420-5

<400>  36

Asn Ser Phe Cys Arg Gly Arg Pro Gly His Phe Gly Gly Cys Tyr Leu 
1               5                   10                  15      


Phe 
    


<210>  37
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX2504LC

<400>  37

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  38
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX2504HC

<400>  38

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Gly Gln Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Ile Gly Asp Ser Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  39
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX2507LC

<400>  39

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Asp Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Ile Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  40
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX2507HC

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Gly Gln Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Ile Gly Asp Ser Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX-CDR-L3

<400>  41

Ala Ser Tyr Ala Gly Ser Gly Ile Val Tyr 
1               5                   10  


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX-CDR-L2

<400>  42

Gly Asp Ser Gln Arg Pro Ser 
1               5           


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX-CDR-H1

<400>  43

Glu Tyr Ala Met Gly 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX-CDR-H2

<400>  44

Ser Ile Gly Ser Ser Gly Gly Gln Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFcRN amino acid sequence

<400>  45

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


