                         SEQUENCE LISTING

<110>  Tan, Joshua H.Y.
       Dobbs Crompton, Peter
       Seder, Robert
       Cho, Hyeseon
 
<120>  HUMAN MONOCLONAL ANTIBODY THAT TARGETS A CONSERVED SITE ON THE 
       PLASMODIUM FALCIPARUM CIRCUMSPOROZOITE PROTEIN

<130>  4239-104602-02

<150>  63/041,439
<151>  2020-06-19

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Glu Ser Ile Ser Asn Ser 
            20                  25                  30          


Ala Tyr Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Ile Ala Thr Val Tyr Tyr Thr Gly Arg Thr Tyr His Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ala Ile Ser Met Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Ile Val Val Thr Thr Pro Asp Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Pro Gly Ala Leu Val Thr Val Ser Ala 
        115                 120             


<210>  2
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Glu Leu Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Asn Val Gln Met Lys 
            100                 105     


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Glu Ser Ile Ser Asn Ser Ala Tyr Tyr 
1               5                   10  


<210>  4
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Tyr Tyr Thr Gly Arg Thr 
1               5           


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Arg Thr Gly Ile Val Val Thr Thr Pro Asp Trp Phe Asp Pro 
1               5                   10                  15  


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Asp Ile Arg Asn Tyr 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ala Ser 
1           


<210>  8
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Tyr Gly Glu Leu Ile Thr 
1               5               


<210>  9
<211>  370
<212>  DNA
<213>  Homo sapiens

<400>  9
cagctgcagt tgcaggagtc gggcccagga ctggtgaagc cctcggagac cctgtccctc       60

acttgctctg tctctggtga atccatcagc aatagcgctt actactgggc ctggatccgc      120

cagcccccag ggaaggccct ggaatggatc gcgactgtct attatactgg acgcacctac      180

cacaatccgt ccctcaagag tcgagtcgcc atatcaatgg acacgtccaa gaaccagttt      240

tctttgaagc tgaggtctgt gacggccgcg gacacggccg tgtattactg tgcgaggacg      300

gggatcgttg ttacgacccc agactggttc gacccctggg gcccgggagc cctggtcacc      360

gtctccgcgg                                                             370


<210>  10
<211>  319
<212>  DNA
<213>  Homo sapiens

<400>  10
gacatccaga tgacccagtc tccatcctcc ctgtctgcgt ctgtgggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagg aactatttaa attggtatca gcagagacca      120

gggaaagccc ctaaactcct gatcttcgat gcatccaact tggaaacagg ggtcccatcc      180

aggttcagtg gaagtggatc tgggacacat tttaccttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatggtgagc tcatcacttt cggcggaggg      300

accaatgtgc agatgaaac                                                   319


<210>  11
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  11

Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn Glu Asp Asn 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  12

Gly Glu Asn Asp Asp Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  13

Asp Gly Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  14

Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys Leu Lys 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  15

Lys Leu Arg Lys Pro Lys His Lys Lys Leu Lys Gln Pro Ala Asp 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  16

Pro Lys His Lys Lys Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  17

Lys Leu Lys Gln Pro Ala Asp Gly Asn Pro Asp Pro Asn Ala Asn 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  18

Pro Ala Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn Val Asp 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  19

Asn Pro Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  20

Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp 
1               5                   10                  15  


<210>  21
<211>  397
<212>  PRT
<213>  Plasmodium falciparum

<400>  21

Met Met Arg Lys Leu Ala Ile Leu Ser Val Ser Ser Phe Leu Phe Val 
1               5                   10                  15      


Glu Ala Leu Phe Gln Glu Tyr Gln Cys Tyr Gly Ser Ser Ser Asn Thr 
            20                  25                  30          


Arg Val Leu Asn Glu Leu Asn Tyr Asp Asn Ala Gly Thr Asn Leu Tyr 
        35                  40                  45              


Asn Glu Leu Glu Met Asn Tyr Tyr Gly Lys Gln Glu Asn Trp Tyr Ser 
    50                  55                  60                  


Leu Lys Lys Asn Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn 
65                  70                  75                  80  


Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys Leu Lys Gln 
                85                  90                  95      


Pro Ala Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
            100                 105                 110         


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
        115                 120                 125             


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    130                 135                 140                 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
145                 150                 155                 160 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
                165                 170                 175     


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            180                 185                 190         


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro 
        195                 200                 205             


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    210                 215                 220                 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
225                 230                 235                 240 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
                245                 250                 255     


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            260                 265                 270         


Asn Lys Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp 
        275                 280                 285             


Pro Asn Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Ser Ala Val Lys 
    290                 295                 300                 


Asn Asn Asn Asn Glu Glu Pro Ser Asp Lys His Ile Lys Glu Tyr Leu 
305                 310                 315                 320 


Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val 
                325                 330                 335     


Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn 
            340                 345                 350         


Lys Pro Lys Asp Glu Leu Asp Tyr Ala Asn Asp Ile Glu Lys Lys Ile 
        355                 360                 365             


Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser 
    370                 375                 380                 


Ile Gly Leu Ile Met Val Leu Ser Phe Leu Phe Leu Asn 
385                 390                 395         


<210>  22
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Lys Ala Gly Asn Gly Asn Thr Arg Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Leu Leu Thr Val Leu Thr Pro Asp Asp Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  23
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val 
        35                  40                  45              


Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Asn Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys His Gln Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  24
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ile Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Phe Asp Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Met Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Arg Asn Phe Tyr Asp Gly Ser Gly Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  25
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Phe Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Val Ala Thr Tyr Tyr Cys Gln Glu Tyr Thr Ser Tyr Gly Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  4
<212>  PRT
<213>  Plasmodium falciparum

<400>  26

Asn Pro Asn Val 
1               


<210>  27
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  27

Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Plasmodium falciparum

<400>  28

Asn Pro Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn 
1               5                   10                  15  


<210>  29
<211>  5
<212>  PRT
<213>  Plasmodium falciparum

<400>  29

Lys Leu Lys Gln Pro 
1               5   


