                         SEQUENCE LISTING

<110>  KIROMIC BIOPHARMA INC.
 
<120>  TRISWITCH TECHNOLOGY FOR MULTI-DIMENSIONAL CONTROL OF CELL 
       THERAPY

<130>  6787.141616PCT

<140>  PCT/US2021/037444
<141>  2021-06-15

<150>  US 63/039,364
<151>  2020-06-15

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hFKBP12-V36

<400>  1

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  2
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hFKBP12-V36

<400>  2
atgggggttc aggtcgaaac aatcagcccg ggagacggca ggacttttcc aaaaaggggg       60

caaacctgcg tcgtacacta tactggtatg ttggaggacg gcaagaaagt cgatagctca      120

agggaccgca acaagccctt taaatttatg ttggggaaac aggaagtgat cagaggatgg      180

gaagaaggag tggcccagat gtcagtgggg cagcgagcga aactcactat ttcccccgat      240

tacgcttatg gtgctaccgg ccaccctggc ataatccctc cgcatgcaac gttggtattc      300

gatgtggaac tgcttaaact tgag                                             324


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  3

Ser Gly Gly Gly Ser Gly 
1               5       


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  4
agcggaggag gtagcggt                                                     18


<210>  5
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Delta - Caspase-9 (w deleted CARD domain)

<400>  5

Val Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn 
1               5                   10                  15      


Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu 
            20                  25                  30          


Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg 
        35                  40                  45              


Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser 
    50                  55                  60                  


Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met 
65                  70                  75                  80  


Val Leu Ala Leu Leu Glu Leu Ala Arg Gln Asp His Gly Ala Leu Asp 
                85                  90                  95      


Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu 
            100                 105                 110         


Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val 
        115                 120                 125             


Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly 
    130                 135                 140                 


Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys 
145                 150                 155                 160 


Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro 
                165                 170                 175     


Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg 
            180                 185                 190         


Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp 
        195                 200                 205             


Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp 
    210                 215                 220                 


Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu 
225                 230                 235                 240 


Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala 
                245                 250                 255     


Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe 
            260                 265                 270         


Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser Ala Ser Arg Ala 
        275                 280                 285             


<210>  6
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Delta-Caspase-9 (w deleted CARD domain)

<400>  6
gtagatggtt tcggggatgt gggagctctt gaaagtttgc gaggtaatgc ggacctcgcg       60

tatatcctgt caatggaacc ttgtggccac tgtcttatca ttaacaacgt aaacttttgt      120

agggagtctg gtctcagaac ccgaacagga tctaacattg actgtgaaaa actgcggaga      180

cgattctcct ctcttcactt tatggttgaa gtaaagggcg atttgactgc aaagaagatg      240

gttctcgcat tgttggaact cgcgcggcaa gaccatggtg cgcttgactg ttgcgtggtg      300

gtcatactgt ctcatggttg ccaagcgtcc catctccaat ttcctggagc tgtttatgga      360

acggatgggt gccctgtgtc agtcgaaaag atagttaaca tcttcaatgg caccagctgt      420

ccttctctgg gagggaagcc aaaactcttc tttatccagg catgcggagg agagcagaaa      480

gaccatggtt tcgaggtggc ctcaacaagt cctgaggatg agagtcctgg tagcaaccct      540

gagccagacg ctactccgtt ccaagaaggc ctgagaacct tcgaccagct ggatgccatt      600

agtagcttgc ctaccccatc cgatatattt gtttcctatt caacctttcc agggtttgtc      660

tcatggcgcg acccaaagag cggcagctgg tatgtggaga cgctcgacga cattttcgag      720

caatgggcgc actctgaaga cctccagtca ctcctgcttc gcgtagccaa cgccgtaagt      780

gtcaagggga tttacaagca gatgcctggg tgctttaact ttcttagaaa aaaacttttt      840

tttaaaacgt ccgcgtcaag ggct                                             864


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: GSG-T2A

<400>  7

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  8
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: GSG-T2A

<400>  8
ggcagtggtg aggggagggg ttcccttctg acgtgtggtg atgtggagga aaacccaggg       60

cct                                                                     63


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a Signal Peptide

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  10
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a Signal Peptide

<400>  10
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

cca                                                                     63


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD34 epitope

<400>  11

Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210>  12
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD34 epitope

<400>  12
gaattgccta cgcaggggac tttttcaaat gtaagcacga atgtgagc                    48


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FMC63 scFv-VL

<400>  13

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FMC63 scFv-VL

<400>  14
gacattcaga tgacgcaaac gaccagctcc ctgtcagcat ccctgggaga tagggttaca       60

atctcttgcc gggccagcca ggatatatcc aaatatctta attggtatca acaaaagccc      120

gatgggaccg taaaactgct tatataccat acatcaagac tgcattctgg cgtaccgagt      180

aggttttccg gtagtggatc agggaccgac tatagcctga ctatatccaa cttggaacaa      240

gaggacattg ctacgtattt ttgtcagcaa gggaatacgc tcccatatac attcggcggg      300

ggaacaaaac ttgaaatcac t                                                321


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: GS linker

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: GS linker

<400>  16
ggagggggag gctcaggagg tgggggttcc ggtggtggcg gtagc                       45


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FMC63 scFv-VH

<400>  17

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FMC63 scFv-VH

<400>  18
gaggtcaaac tccaggaaag tggtccgggc ctcgtagctc cgagtcaatc cttgagcgtg       60

acctgtaccg taagcggtgt tagtctccct gactatggtg tcagttggat acgacaaccg      120

ccacgcaagg gcctggaatg gttgggtgtt atttggggtt cagaaactac gtactataac      180

agcgccctca aatcacggct gacgatcata aaagacaatt ccaaatctca ggtctttttg      240

aagatgaata gccttcaaac cgacgatacc gccatatact attgtgctaa gcattactat      300

tacggggggt cctacgctat ggattactgg ggacaaggaa caagcgtgac cgtttcatca      360


<210>  19
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a stalk

<400>  19

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  20
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a stalk

<400>  20
acgacgacac cagccccaag acccccaact cccgctccta ccatagcttc ccaacccctg       60

tcactgaggc cagaggcatg caggcccgct gcgggtggcg cggtacatac gcggggactg      120

gactttgcat gtgac                                                       135


<210>  21
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a TM

<400>  21

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
            20                  25                  30          


Cys Lys Cys Pro Arg 
        35          


<210>  22
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8a TM

<400>  22
atttacatat gggcgccact ggcgggaaca tgtggagttt tgttgcttag cctggtcata       60

acactgtatt gcaatcatcg caacagacgc cgcgtctgca agtgtcccag g               111


<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD28 cyt

<400>  23

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  24
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD28 cyt

<400>  24
agatctaaga gaagtagact tcttcacagt gattatatga atatgacgcc tcgaagaccc       60

ggcccgacac gcaaacacta tcagccgtat gccccccctc gggattttgc tgcctaccgc      120

agc                                                                    123


<210>  25
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD3z cyt

<400>  25

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  26
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD3z cyt

<400>  26
cgcgttaagt tctctaggtc cgctgacgcc cctgcctacc agcagggtca aaaccaactg       60

tacaatgaat tgaatcttgg gagacgggag gagtatgacg tactcgacaa gcggaggggg      120

agagatcctg agatgggtgg aaagcctcga cgaaaaaacc cacaagaagg gttgtataat      180

gaactgcaga aagacaagat ggctgaggca tatagtgaaa tcgggatgaa gggagaacgc      240

cggcgcggga aagggcacga tggtctgtat caagggctta gtacggctac gaaggacaca      300

tatgacgctt tgcacatgca ggcccttcct cctagg                                336


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hFKBP12

<400>  27

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  28
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hFKBP12

<400>  28
ggagtgcagg tggagactat ctccccagga gacgggcgca ccttccccaa gcgcggccag       60

acctgcgtgg tgcactacac cgggatgctt gaagatggaa agaaattcga ttcctcccgg      120

gacagaaaca agccctttaa gtttatgcta ggcaagcagg aggtgatccg aggctgggaa      180

gaaggggttg cccagatgag tgtgggtcag agagccaaac tgactatatc tccagattat      240

gcctatggtg ccactgggca cccaggcatc atcccaccac atgccactct cgtcttcgat      300

gtggagcttc taaaactgga a                                                321


<210>  29
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FRB (hMTOR (E2021-K2109)

<400>  29

Met Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
1               5                   10                  15      


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
            20                  25                  30          


Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
        35                  40                  45              


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
    50                  55                  60                  


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu 
65                  70                  75                  80  


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90  


<210>  30
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FRB (hMTOR (E2021-K2109)

<400>  30
gagatgtggc acgaaggact ggaagaagca tctcgactct acttcggaga aagaaacgtc       60

aagggaatgt tcgaggtctt ggaaccactc cacgctatga tggagagagg accacaaact      120

cttaaagaaa cctcctttaa tcaagcttac ggccgagacc ttatggaagc tcaagagtgg      180

tgcaggaaat acatgaagag cggaaacgtg aaggacctga ctcaagcctg ggacctgtac      240

tatcatgtct ttaggcggat cagtaaa                                          267


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  31

Ser Gly Gly Gly Ser Gly 
1               5       


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Linker

<400>  32
tctgggggag gatctggc                                                     18


<210>  33
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FRB (hMTOR (E2021-K2109)

<400>  33

Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
1               5                   10                  15      


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
            20                  25                  30          


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
        35                  40                  45              


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
    50                  55                  60                  


Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp Leu Tyr 
65                  70                  75                  80  


Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  


<210>  34
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FRB (hMTOR (E2021-K2109)

<400>  34
gaaatgtggc acgagggtct tgaagaggca tcccgattgt atttcggaga gagaaacgtt       60

aaagggatgt tcgaggtgtt ggagccctta catgcaatga tggaacgggg cccccaaaca      120

ctcaaagaga caagctttaa tcaagcatat gggagggacc ttatggaggc gcaggaatgg      180

tgccgaaagt acatgaaatc cggtaacgtg aaggatctca cccaggcttg ggatctgtat      240

tatcatgtct tcagaaggat tagtaag                                          267


<210>  35
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hPD1 cyt (ITIM, ITSM)

<400>  35

Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
1               5                   10                  15      


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
            20                  25                  30          


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
        35                  40                  45              


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
    50                  55                  60                  


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
65                  70                  75                  80  


Cys Ser Trp Pro Leu 
                85  


<210>  36
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hPD1 cyt (ITIM, ITSM)

<400>  36
cgcaccgggc agccgctgaa ggaggaccca tctgccgttc cagttttctc agtagactac       60

ggcgaacttg acttccagtg gcgggaaaag acacccgaac ccccagttcc gtgtgtcccg      120

gagcagaccg agtatgctac gatcgtattc ccttctggaa tggggacttc aagccctgca      180

cgccgaggct cagccgacgg gccaagaagc gcacagcctc tgaggccgga agatggtcat      240

tgcagctggc cgctc                                                       255


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: GSG-T2A

<400>  37

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  38
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: GSG-T2A

<400>  38
ggatccggtg aggggagggg ttcccttctg acgtgtggtg atgtggagga aaacccaggg       60

cct                                                                     63


<210>  39
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Delta -hNGFR (SP, Ext, TM, Cyt)

<400>  39

Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys Pro 
            20                  25                  30          


Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn Leu 
        35                  40                  45              


Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys Glu 
    50                  55                  60                  


Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr Glu 
65                  70                  75                  80  


Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser Ala 
                85                  90                  95      


Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly Tyr 
            100                 105                 110         


Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys Glu 
        115                 120                 125             


Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr Val 
    130                 135                 140                 


Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His Val 
145                 150                 155                 160 


Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln Leu 
                165                 170                 175     


Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro Gly 
            180                 185                 190         


Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr Ala 
        195                 200                 205             


Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile Ala 
    210                 215                 220                 


Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln Pro 
225                 230                 235                 240 


Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys Ser 
                245                 250                 255     


Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe Lys 
            260                 265                 270         


Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
        275                 280                 285         


<210>  40
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Delta-hNGFR (SP, Ext, TM, Cyt)

<400>  40
ggggctggcg caaccggcag agctatggat ggacccagac tgctgctgct cctgcttctc       60

ggtgtgtcac ttggtggtgc aaaagaagcg tgccctactg gactctacac gcattctgga      120

gaatgctgta aagcgtgcaa ccttggagaa ggggtggccc aaccatgtgg tgctaatcag      180

actgtctgcg agccttgctt ggattcagta acattttctg atgttgtttc tgcaacggaa      240

ccttgtaagc cttgcaccga gtgtgttggg ctccaaagca tgtctgcacc gtgcgtcgaa      300

gcggatgatg ctgtctgccg gtgtgcttat ggctactatc aggatgaaac gacgggtagg      360

tgcgaagcct gccgcgtttg cgaggcgggt agtggcctgg tgtttagttg tcaagacaag      420

caaaacaccg tttgtgagga gtgcccagat gggacgtaca gcgatgaagc taatcatgtt      480

gatccctgtc tcccctgtac ggtttgcgaa gacacggaac gacaactgcg agaatgtact      540

cgctgggcgg acgccgaatg tgaggagatc cctggtagat ggatcactcg ctcaacaccg      600

cctgaagggt cagactcaac cgcaccaagt acgcaagagc ctgaagcacc tcctgagcag      660

gaccttatcg cttctacagt agctggggta gtgaccaccg ttatgggctc ttcccaacct      720

gttgtgacaa ggggcacaac tgataatttg attcctgttt actgttctat tctcgccgcc      780

gtagtagtag gtcttgtagc atatattgcg tttaagcggt ggaatagttg caaacagaac      840

aaacagggtg cgaacagccg c                                                861


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: GSG-P2A

<400>  41

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  42
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: GSG-P2A

<400>  42
gggagcggcg ctacaaattt tagcctgctc aagcaggccg gtgacgtaga ggaaaacccc       60

ggtccg                                                                  66


<210>  43
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FRB-T2094

<400>  43

Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly 
1               5                   10                  15      


Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala 
            20                  25                  30          


Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln 
        35                  40                  45              


Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr 
    50                  55                  60                  


Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr 
65                  70                  75                  80  


Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  


<210>  44
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FRB-T2094

<400>  44
gaaatgtggc atgagggtct ggaagaggct agtcgccttt actttggcga acggaatgtc       60

aaagggatgt ttgaagtact tgaacctctt cacgcgatga tggaaagggg gccacaaaca      120

ctcaaggaaa ctagcttcaa tcaagcgtat ggtcgcgatc ttatggaggc tcaggagtgg      180

tgccgaaagt acatgaagag tggtaacgtt aaggacctcc tccaagcatg ggatttgtac      240

taccatgtct ttcgacgcat ttcgaag                                          267


<210>  45
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: dSH3.hLck-F505

<400>  45

Glu Pro Glu Pro Trp Phe Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu 
1               5                   10                  15      


Arg Gln Leu Leu Ala Pro Gly Asn Thr His Gly Ser Phe Leu Ile Arg 
            20                  25                  30          


Glu Ser Glu Ser Thr Ala Gly Ser Phe Ser Leu Ser Val Arg Asp Phe 
        35                  40                  45              


Asp Gln Asn Gln Gly Glu Val Val Lys His Tyr Lys Ile Arg Asn Leu 
    50                  55                  60                  


Asp Asn Gly Gly Phe Tyr Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu 
65                  70                  75                  80  


His Glu Leu Val Arg His Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr 
                85                  90                  95      


Arg Leu Ser Arg Pro Cys Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp 
            100                 105                 110         


Glu Asp Glu Trp Glu Val Pro Arg Glu Thr Leu Lys Leu Val Glu Arg 
        115                 120                 125             


Leu Gly Ala Gly Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly 
    130                 135                 140                 


His Thr Lys Val Ala Val Lys Ser Leu Lys Gln Gly Ser Met Ser Pro 
145                 150                 155                 160 


Asp Ala Phe Leu Ala Glu Ala Asn Leu Met Lys Gln Leu Gln His Gln 
                165                 170                 175     


Arg Leu Val Arg Leu Tyr Ala Val Val Thr Gln Glu Pro Ile Tyr Ile 
            180                 185                 190         


Ile Thr Glu Tyr Met Glu Asn Gly Ser Leu Val Asp Phe Leu Lys Thr 
        195                 200                 205             


Pro Ser Gly Ile Lys Leu Thr Ile Asn Lys Leu Leu Asp Met Ala Ala 
    210                 215                 220                 


Gln Ile Ala Glu Gly Met Ala Phe Ile Glu Glu Arg Asn Tyr Ile His 
225                 230                 235                 240 


Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Ser Asp Thr Leu Ser Cys 
                245                 250                 255     


Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr 
            260                 265                 270         


Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu 
        275                 280                 285             


Ala Ile Asn Tyr Gly Thr Phe Thr Ile Lys Ser Asp Val Trp Ser Phe 
    290                 295                 300                 


Gly Ile Leu Leu Thr Glu Ile Val Thr His Gly Arg Ile Pro Tyr Pro 
305                 310                 315                 320 


Gly Met Thr Asn Pro Glu Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg 
                325                 330                 335     


Met Val Arg Pro Asp Asn Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg 
            340                 345                 350         


Leu Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu 
        355                 360                 365             


Arg Ser Val Leu Glu Asp Phe Phe Thr Ala Thr Glu Gly Gln Phe Gln 
    370                 375                 380                 


Pro Gln Pro 
385         


<210>  46
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: dSH3.hLck-F505

<400>  46
gagcccgaac cctggttctt caagaacctg agccgcaagg acgcggagcg gcagctcctg       60

gcgcccggga acactcacgg ctccttcctc atccgggaga gcgagagcac cgcaggatcg      120

ttttcactgt cagtccggga cttcgaccag aaccagggag aggtggtgaa acattacaag      180

atccgtaatc tggacaacgg tggcttctac atctcccctc gaatcacttt tcccggcctg      240

catgaactgg tccgccatta caccaatgct tcagatgggc tgtgcacacg gttgagccgc      300

ccctgccaga cccagaagcc ccagaagccg tggtgggagg acgagtggga ggttcccagg      360

gagacgctga agctggtgga gcggctgggg gctggacagt tcggggaggt gtggatgggg      420

tactacaacg ggcacacgaa ggtcgcggtg aagagcctga agcagggcag catgtccccg      480

gacgccttcc tggccgaggc caacctcatg aagcagctgc aacaccagcg gctggttcgg      540

ctctacgctg tggtcaccca ggagcccatc tacatcatca ctgaatacat ggagaatggg      600

agtctagtgg attttctcaa gaccccttca ggcatcaagt tgaccatcaa caaactcctg      660

gacatggcag cccaaattgc agaaggcatg gcattcattg aagagcggaa ttatattcat      720

cgtgaccttc gggctgccaa cattctggtg tctgacaccc tgagctgcaa gattgcagac      780

tttggcctag cacgcctcat tgaggacaac gagtacacag ccagggaggg ggccaagttt      840

cccattaagt ggacagcgcc agaagccatt aactacggga cattcaccat caagtcagat      900

gtgtggtctt ttggaatcct gctgacggaa attgtcaccc acggccgcat cccttaccca      960

gggatgacca acccggaggt gattcagaac ctggagcgag gctaccgcat ggtgcgccct     1020

gacaactgtc cagaggagct gtaccaactc atgaggctgt gctggaagga gcgcccagag     1080

gaccggccca cctttgacta cctgcgcagt gtgctggagg acttcttcac ggccacagag     1140

ggccagttcc agcctcagcc ttga                                            1164


