                         SEQUENCE LISTING

<110>  Sarepta Therapeutics, Inc.
 
<120>  ADENO-ASSOCIATED VIRUS ANTIBODIES AND FRAGMENTS THEREOF

<130>  8176.WO00

<150>  63/038,957
<151>  2020-06-15

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Heavy chain variable region

<400>  1

Met Asp Trp Leu Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Thr Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Arg Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Thr Pro Gly Lys Asp Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Ala Ser Ala Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Met Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Val Ala His Tyr Ser Asp Ser Arg Phe Ala 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Pro Ser 
    130                 135                 140         


<210>  2
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Light chain variable region

<400>  2

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210>  3
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10D2-1 Heavy chain variable region full nucleotide

<400>  3
atggattggc tgtggaactt gctattcctg atggcagctg cccaaagtgc ccaaacacag       60

atccagttgg tgcagtctgg acctgagttg aggaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctggatattc cttcacaaac tatggaatga actgggtgaa gcagactcca      180

ggaaaggatt taaagtggat gggctggata aacacctaca ctggagagcc aacatatgct      240

gatgacttca agggacggtt cgccttctct ctggaagcct ctgccaacac tgcctatttg      300

cagatcaacg acctcaaaaa tgaggacatg gctacatatt tctgtgcaag gggtgtggct      360

cattactccg atagtaggtt cgcctttgac tactggggcc aaggaaccac tctcacagtc      420

ccctcc                                                                 426


<210>  4
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10D2-1 Light chain variable region full nucleotide sequence

<400>  4
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttctcac ccagtcacca gcaatcatgt ctgcatctcc aggggagaag      120

gtcaccataa cctgcagtgt cagctcaagt gttagttaca tgcactggtt ccagcagaag      180

ccaggcactt ctcccaaact ctggatttat tacacatcca acctggcttc tggagtccct      240

ggtcgcttca gtggcagtgg atctgggacc tcttactccc tcacaatcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccatt cacgttcggc      360

tcggggacaa agttggaaat aaaa                                             384


<210>  5
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Heavy chain variable region full amino acid sequence

<400>  5

Met Asp Trp Leu Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Thr Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ala Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Glu Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Gly 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Ala Ser Ala Ser 
                85                  90                  95      


Thr Ala His Leu Gln Ile Asn Asn Leu Lys Asn Asp Asp Met Ala Ile 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Asn Ala His Pro Gly Gly Ser Ala Phe Val 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140 


<210>  6
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Light chain variable region full amino acid sequence

<400>  6

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Ser Val Thr Ile Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Gly Val Thr Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Asn Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210>  7
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28D8-1 Heavy chain variable region full nucleotide sequence

<400>  7
atggattggc tgtggaactt gctattcctg atggcagcag cccaaagcgc ccaaacacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctg ctgggtatac cttcacagac tatggaatga actgggtgaa gcaggctcca      180

ggagagggtt taaagtggat gggctggata aacaccaata ctggagagcc aacatatggt      240

gatgacttca agggacggtt tgccttctct ttggaagcct ctgccagcac tgcccatttg      300

cagatcaaca acctcaaaaa tgacgacatg gcaatatatt tctgtgcaag agggaacgct      360

catcccggtg gtagtgcgtt tgtttactgg ggccaaggga ctctggtcac tgtctctgca      420


<210>  8
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28D8-1 Light chain variable region full nucleotide sequence

<400>  8
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagagt      120

gtcaccataa cctgcagtgc cagctcaggt gtcacttaca tgcactggtt ccagcagaag      180

ccaggcactt ctcccaaaaa ctggatttat agaacatcca atctggcttc tggagtccct      240

gctcgcttca gtggcagtgg atctgggacc tcttactctc tcacaatcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccatt cacattcggc      360

tcggggacaa agttggaaat aaaa                                             384


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 Heavy chain variable region full amino acid sequence

<400>  9

Gln Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Glu Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Lys Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Gly Thr Thr Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Asp Ser Ser Gly Tyr Gly Ala Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 Light chain variable region full amino acid sequence

<400>  10

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Phe Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  11
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6E10B5 Heavy chain variable region full nucleotide sequence

<400>  11
caagttaagc tgcaggagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aagtatggaa tgaactgggt gaagcaggct      120

ccaggagagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttgaaaa cctctgccag tactgcctat      240

ttgcagatca acaacctcaa aaatgagggc acgactacat atttctgtgc aagaggggta      300

gacagctcgg gctacggcgc ctttgcttac tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  12
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6E10B5 Light chain variable region full nucleotide sequence

<400>  12
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagctc aagtgtaagt tacatgcact ggttccagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgcagcca cttattactg ccagcaaagg agtttttacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaacg g                                                321


<210>  13
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 Heavy chain variable region full amino acid sequence

<400>  13

Gln Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Arg Lys Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Tyr Asp Ser Ser Pro Ala Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 Heavy chain variable region full nucleotide sequence

<400>  14

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Thr Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  15
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1C4F4 Heavy chain variable region full nucleotide sequence

<400>  15
caggtgaagc tggaggagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag gaaagtctat      240

ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aaggggttct      300

tattactacg acagtagccc tgcctggttt gcttactggg gccaagggac tctggtcact      360

gtctctgca                                                              369


<210>  16
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1C4F4 Light chain variable region full nucleotide sequence

<400>  16
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagttc aagtgtaagt tacatgcact ggttccagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgag      240

gatgctgcca cttattactg ccagcaaagg agtacttacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaacg g                                                321


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 Heavy chain variable region full amino acid sequence

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Ser Asp Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Thr Ser Thr Met Ile Ser Thr Phe Ala Phe Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 Light chain variable region full amino acid sequence

<400>  18

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Val Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Tyr Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  19
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D4B9 Heavy chain variable region full nucleotide sequence

<400>  19
gaagttcagc tgcaggagtc tggatctgac ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgccttt      240

ttgcaaatca acaacctcaa atatgaggac acgggtacat atttctgtac aagagggact      300

tctactatga tttcgacgtt cgcgtttgtt tactggggcc aagggactct ggtcaccgtc      360

tctgcg                                                                 366


<210>  20
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D4B9 Light chain variable region full nucleotide sequence

<400>  20
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagctc aagtgtacgt tacatgcact ggttccagca gaagccaggc      120

acttctccca aagtctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg acttattacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaacg g                                                321


<210>  21
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 IgG1 Heavy chain variable region full amino acid sequence

<400>  21

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Arg Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Thr Pro Gly Lys Asp Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Ala Ser Ala Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Met Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Val Ala His Tyr Ser Asp Ser Arg Phe Ala 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Pro Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  22
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 IgG1 Light chain variable region full amino acid sequence

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val 
        35                  40                  45              


Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu 
    50                  55                  60                  


Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr 
            100                 105                 110         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  23
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 IgA Heavy chain variable region full amino acid sequence

<400>  23

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Arg Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Thr Pro Gly Lys Asp Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Ala Ser Ala Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Met Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Val Ala His Tyr Ser Asp Ser Arg Phe Ala 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Pro Ser Ala Ser 
    130                 135                 140                 


Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr Gln Pro 
145                 150                 155                 160 


Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro Gln 
                165                 170                 175     


Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr Ala 
            180                 185                 190         


Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr 
        195                 200                 205             


Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys Ser 
    210                 215                 220                 


Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val Thr 
225                 230                 235                 240 


Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu His 
            260                 265                 270         


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
        275                 280                 285             


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr Trp 
    290                 295                 300                 


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
305                 310                 315                 320 


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu 
                325                 330                 335     


Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu 
            340                 345                 350         


Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
        355                 360                 365             


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
    370                 375                 380                 


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
385                 390                 395                 400 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
                405                 410                 415     


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
            420                 425                 430         


Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
        435                 440                 445             


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
    450                 455                 460                 


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His 
465                 470                 475                 480 


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
                485                 490                 495 


<210>  24
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 IgA  Light chain variable region full amino acid sequence

<400>  24

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val 
        35                  40                  45              


Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu 
    50                  55                  60                  


Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Gly Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr 
            100                 105                 110         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  25
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 IgG1 Heavy chain variable region full amino acid sequence

<400>  25

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ala Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Glu Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Gly 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Ala Ser Ala Ser 
                85                  90                  95      


Thr Ala His Leu Gln Ile Asn Asn Leu Lys Asn Asp Asp Met Ala Ile 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Asn Ala His Pro Gly Gly Ser Ala Phe Val 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  26
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 IgG1 Light chain variable region full amino acid sequence

<400>  26

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Ser Val Thr Ile Thr Cys Ser Ala Ser Ser Gly Val 
        35                  40                  45              


Thr Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Asn 
    50                  55                  60                  


Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr 
            100                 105                 110         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  27
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 IgA Heavy chain variable region full amino acid sequence

<400>  27

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ala Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Glu Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Gly 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Ala Ser Ala Ser 
                85                  90                  95      


Thr Ala His Leu Gln Ile Asn Asn Leu Lys Asn Asp Asp Met Ala Ile 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Asn Ala His Pro Gly Gly Ser Ala Phe Val 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Pro Thr 
    130                 135                 140                 


Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr Gln Pro Asp Gly 
145                 150                 155                 160 


Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro Gln Glu Pro 
                165                 170                 175     


Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr Ala Arg Asn 
            180                 185                 190         


Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser 
        195                 200                 205             


Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys Ser Val Thr 
    210                 215                 220                 


Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val Thr Val Pro 
225                 230                 235                 240 


Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro 
                245                 250                 255     


Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu His Arg Pro 
            260                 265                 270         


Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr 
        275                 280                 285             


Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro 
    290                 295                 300                 


Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys 
305                 310                 315                 320 


Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp 
                325                 330                 335     


Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys 
            340                 345                 350         


Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro 
        355                 360                 365             


Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu 
    370                 375                 380                 


Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val 
385                 390                 395                 400 


Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr 
                405                 410                 415     


Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe 
            420                 425                 430         


Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly 
        435                 440                 445             


Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe 
    450                 455                 460                 


Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn 
465                 470                 475                 480 


Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
                485                 490             


<210>  28
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 IgA Light chain variable region full amino acid sequence

<400>  28

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Ser Val Thr Ile Thr Cys Ser Ala Ser Ser Gly Val 
        35                  40                  45              


Thr Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Asn 
    50                  55                  60                  


Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr 
            100                 105                 110         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  29
<211>  1433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28D8-1_mIgG2b-pcDNA3.1(+)

<400>  29
atggattggc tgtggaactt gctattcctg atggcagcag cccaaagcgc ccaaacacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctg ctgggtatac cttcacagac tatggaatga actgggtgaa gcaggctcca      180

ggagagggtt taaagtggat gggctggata aacaccaata ctggagagcc aacatatggt      240

gatgacttca agggacggtt tgccttctct ttggaagcct ctgccagcac tgcccatttg      300

cagatcaaca acctcaaaaa tgacgacatg gcaatatatt tctgtgcaag agggaacgct      360

catcccggtg gtagtgcgtt tgtttactgg ggccaaggga ctctggtcac tgtctctgca      420

gccaaaacaa cacccccatc agtctatcca ctggcccctg ggtgtggaga tacaactggt      480

tcctctgtga ctctgggatg cctggtcaag ggctacttcc ctgagtcagt gactgtgact      540

tggaactctg gatccctgtc cagcagtgtg cacaccttcc cagctctcct gcagtctgga      600

ctctacacta tgagcagctc agtgactgtc ccctccagca cctggccaag tcagaccgtc      660

acctgcagcg ttgctcaccc agccagcagc accacggtgg acaaaaaact tgagcccagc      720

gggcccattt caacaatcaa cccctgtcct ccatgcaagg agtgtcacaa atgcccagct      780

cctaacctcg agggtggacc atccgtcttc atcttccctc caaatatcaa ggatgtactc      840

atgatctccc tgacacccaa ggtcacgtgt gtggtggtgg atgtgagcga ggatgaccca      900

gacgtccgga tcagctggtt tgtgaacaac gtggaagtac acacagctca gacacaaacc      960

catagagagg attacaacag tactatccgg gtggtcagtg ccctccccat ccagcaccag     1020

gactggatga gtggcaagga gttcaaatgc aaggtcaaca acaaagacct cccatcaccc     1080

atcgagagaa ccatctcaaa aattaaaggg ctagtcagag ctccacaagt atacatcttg     1140

ccgccaccag cagagcagtt gtccaggaaa gatgtcagtc tcacttgcct ggtcgtgggc     1200

ttcaaccctg gagacatcag tgtggagtgg accagcaatg ggcatacaga ggagaactac     1260

aaggacaccg caccagtcct ggactctgac ggttcttact tcatatacag caagctcgat     1320

ataaaaacaa gcaagtggga gaaaacagat tccttctcat gcaacgtgag acacgagggt     1380

ctgaaaaatt actacctgaa gaagaccatc tcccggtctc cgggtaaatg agc            1433


<210>  30
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28D8-1_mKappa-pcDNA3.1(+)

<400>  30
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagagt      120

gtcaccataa cctgcagtgc cagctcaggt gtcacttaca tgcactggtt ccagcagaag      180

ccaggcactt ctcccaaaaa ctggatttat agaacatcca atctggcttc tggagtccct      240

gctcgcttca gtggcagtgg atctgggacc tcttactctc tcacaatcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccatt cacattcggc      360

tcggggacaa agttggaaat aaaa                                             384


<210>  31
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10D2-1_mIgG1-pcDNA3.1(+)

<400>  31
atggattggc tgtggaactt gctattcctg atggcagctg cccaaagtgc ccaaacacag       60

atccagttgg tgcagtctgg acctgagttg aggaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctggatattc cttcacaaac tatggaatga actgggtgaa gcagactcca      180

ggaaaggatt taaagtggat gggctggata aacacctaca ctggagagcc aacatatgct      240

gatgacttca agggacggtt cgccttctct ctggaagcct ctgccaacac tgcctatttg      300

cagatcaacg acctcaaaaa tgaggacatg gctacatatt tctgtgcaag gggtgtggct      360

cattactccg atagtaggtt cgcctttgac tactggggcc aaggaaccac tctcacagtc      420

ccctcc                                                                 426


<210>  32
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10D2-1_mKappa-pcDNA3.1(+)

<400>  32
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttctcac ccagtcacca gcaatcatgt ctgcatctcc aggggagaag      120

gtcaccataa cctgcagtgt cagctcaagt gttagttaca tgcactggtt ccagcagaag      180

ccaggcactt ctcccaaact ctggatttat tacacatcca acctggcttc tggagtccct      240

ggtcgcttca gtggcagtgg atctgggacc tcttactccc tcacaatcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccatt cacgttcggc      360

tcggggacaa agttggaaat aaaa                                             384


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Heavy chain variable region CDR1

<400>  33

Asn Tyr Gly Met Asn 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Heavy chain variable region CDR2

<400>  34

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Heavy chain variable region CDR3

<400>  35

Gly Val Ala His Tyr Ser Asp Ser Arg Phe Ala Phe Asp Tyr 
1               5                   10                  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Light chain variable region CDR1

<400>  36

Ser Val Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Light chain variable region CDR2

<400>  37

Tyr Thr Ser Asn Leu Ala Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10D2-1 Light chain variable region CDR3

<400>  38

Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Heavy chain variable region CDR1

<400>  39

Asp Tyr Gly Met Asn 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Heavy chain variable region CDR2

<400>  40

Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Gly Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Heavy chain variable region CDR3

<400>  41

Gly Asn Ala His Pro Gly Gly Ser Ala Phe Val Tyr 
1               5                   10          


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Light chain variable region CDR1

<400>  42

Ser Ala Ser Ser Gly Val Thr Tyr Met His 
1               5                   10  


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Light chain variable region CDR2

<400>  43

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28D8-1 Light chain variable region CDR3 amino acid sequence

<400>  44

Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser 
1               5                   10          


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 HC ARB1

<400>  46

Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 HC ARB2

<400>  47

Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
1               5                   10                  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 HC ARB3

<400>  48

Arg Gly Ser Tyr Tyr Tyr Asp Ser Ser Pro Ala Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 LC ARB1

<400>  49

Ser Ser Val Ser Tyr Met His 
1               5           


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 LC  ARB2

<400>  50

Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C4F4 LC  ARB3

<400>  51

Gln Gln Arg Ser Thr Tyr Pro Phe 
1               5               


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 HC ARB1

<400>  52

Tyr Thr Phe Thr Lys Tyr Gly Met Asn 
1               5                   


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 HC ARB2

<400>  53

Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
1               5                   10                  


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 HC ARB3

<400>  54

Arg Gly Val Asp Ser Ser Gly Tyr Gly Ala Phe Ala Tyr 
1               5                   10              


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 LC ARB1

<400>  55

Ser Ser Val Ser Tyr Met His 
1               5           


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 LC ARB2

<400>  56

Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E10B5 LC ARB3

<400>  57

Gln Gln Arg Ser Phe Tyr Pro Phe 
1               5               


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 HC ARB1

<400>  58

Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 HC ARB2

<400>  59

Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
1               5                   10                  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 HC ARB3

<400>  60

Thr Arg Gly Thr Ser Thr Met Ile Ser Thr Phe Ala Phe Val Tyr 
1               5                   10                  15  


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 LC ARB1

<400>  61

Ser Ser Val Arg Tyr Met His 
1               5           


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 LC ARB2

<400>  62

Val Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D4B9 LC ARB3

<400>  63

Gln Gln Arg Thr Tyr Tyr Pro Phe 
1               5               


