                         SEQUENCE LISTING

<110>  Catalyst Biosciences, Inc.
 
<120>  COMPLEMENT FACTOR I-RELATED COMPOSITIONS AND METHODS

<130>  CTBI-001/04WO 338308-2109

<150>  63/122,437
<151>  2020-12-07

<150>  63/179,160
<151>  2021-04-23

<150>  63/124,698
<151>  2020-12-11

<150>  63/038,874
<151>  2020-06-14

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  583
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  2
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  3
<211>  18
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys 
        


<210>  4
<211>  1231
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  5
<211>  565
<212>  PRT
<213>  Homo Sapiens

<400>  5

Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys Cys Leu 
1               5                   10                  15      


Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys Gln Pro 
            20                  25                  30          


Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro Tyr Gln 
        35                  40                  45              


Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg Ser Phe 
    50                  55                  60                  


Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro Gly Thr 
65                  70                  75                  80  


Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe Ser Val 
                85                  90                  95      


Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu Val Lys 
            100                 105                 110         


Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser Trp Ser 
        115                 120                 125             


Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln Gln Gly 
    130                 135                 140                 


Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile Asn Ser 
145                 150                 155                 160 


Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser Leu Ala 
                165                 170                 175     


Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp Phe Ala 
            180                 185                 190         


Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp Asp Phe 
        195                 200                 205             


Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala Cys Asp 
    210                 215                 220                 


Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys Lys Ala 
225                 230                 235                 240 


Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile Pro Ser 
                245                 250                 255     


Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu Asp Glu 
            260                 265                 270         


Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr Glu Ile 
        275                 280                 285             


Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu 
    290                 295                 300                 


Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg Arg Lys 
305                 310                 315                 320 


Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln 
                325                 330                 335     


Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile 
            340                 345                 350         


Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys 
        355                 360                 365             


Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro 
    370                 375                 380                 


Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His 
385                 390                 395                 400 


Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu 
                405                 410                 415     


Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile 
            420                 425                 430         


Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr 
        435                 440                 445             


Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe 
    450                 455                 460                 


Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe 
465                 470                 475                 480 


Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr 
                485                 490                 495     


Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val 
            500                 505                 510         


Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp 
        515                 520                 525             


Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val 
    530                 535                 540                 


Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile 
545                 550                 555                 560 


Ser Gln Tyr Asn Val 
                565 


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  6

Gly Gly Ser Ser Gly Gly 
1               5       


<210>  7
<211>  585
<212>  PRT
<213>  Homo Sapiens

<400>  7

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  8
<211>  415
<212>  PRT
<213>  Homo Sapiens

<400>  8

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Ala Gly Gly Gly Gly Gly Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn 
        275                 280                 285             


Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser 
    290                 295                 300                 


Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg 
305                 310                 315                 320 


Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His 
                325                 330                 335     


Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu 
            340                 345                 350         


Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val 
        355                 360                 365             


Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr 
    370                 375                 380                 


Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala 
385                 390                 395                 400 


Lys Arg Glu Asn Leu Tyr Phe Gln Gly His His His His His His 
                405                 410                 415 


<210>  9
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  9

Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
1               5                   10  


<210>  10
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  10

Asn Thr Ala Ser Ser Gly Ala Asp Tyr Pro Asp Glu 
1               5                   10          


<210>  11
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  11

Arg Gly Lys Asp Asn Gln Lys Val Tyr Ser 
1               5                   10  


<210>  12
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  12

Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg Arg Lys Arg 
1               5                   10                  15      


Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
            20                  25                  30          


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
        35                  40                  45              


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
    50                  55                  60                  


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
65                  70                  75                  80  


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
                85                  90                  95      


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
            100                 105                 110         


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
        115                 120                 125             


Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys 
    130                 135                 140                 


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
145                 150                 155                 160 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr 
                165                 170                 175     


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
            180                 185                 190         


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
        195                 200                 205             


Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
    210                 215                 220                 


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
225                 230                 235                 240 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser 
                245                 250                 255     


Gln Tyr Asn Val 
            260 


<210>  13
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  13

Met Asp Ala Asn Asn Val Thr 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  14

Pro Phe Ile Ser Gln Tyr Asn Val 
1               5               


<210>  15
<211>  4
<212>  PRT
<213>  Homo Sapiens

<400>  15

Asp Gly Asn Lys 
1               


<210>  16
<211>  1135
<212>  PRT
<213>  Homo Sapiens

<400>  16

Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys Cys Leu 
1               5                   10                  15      


Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys Gln Pro 
            20                  25                  30          


Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro Tyr Gln 
        35                  40                  45              


Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg Ser Phe 
    50                  55                  60                  


Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro Gly Thr 
65                  70                  75                  80  


Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe Ser Val 
                85                  90                  95      


Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu Val Lys 
            100                 105                 110         


Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser Trp Ser 
        115                 120                 125             


Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln Gln Gly 
    130                 135                 140                 


Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile Asn Ser 
145                 150                 155                 160 


Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser Leu Ala 
                165                 170                 175     


Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp Phe Ala 
            180                 185                 190         


Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp Asp Phe 
        195                 200                 205             


Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala Cys Asp 
    210                 215                 220                 


Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys Lys Ala 
225                 230                 235                 240 


Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile Pro Ser 
                245                 250                 255     


Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu Asp Glu 
            260                 265                 270         


Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr Glu Ile 
        275                 280                 285             


Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu 
    290                 295                 300                 


Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg Arg Lys 
305                 310                 315                 320 


Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln 
                325                 330                 335     


Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile 
            340                 345                 350         


Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys 
        355                 360                 365             


Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro 
    370                 375                 380                 


Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His 
385                 390                 395                 400 


Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu 
                405                 410                 415     


Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile 
            420                 425                 430         


Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr 
        435                 440                 445             


Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe 
    450                 455                 460                 


Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe 
465                 470                 475                 480 


Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr 
                485                 490                 495     


Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val 
            500                 505                 510         


Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp 
        515                 520                 525             


Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val 
    530                 535                 540                 


Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile 
545                 550                 555                 560 


Ser Gln Tyr Asn Val Gly Ser Ser Gly Gly Lys Val Thr Tyr Thr Ser 
                565                 570                 575     


Gln Glu Asp Leu Val Glu Lys Lys Cys Leu Ala Lys Lys Tyr Thr His 
            580                 585                 590         


Leu Ser Cys Asp Lys Val Phe Cys Gln Pro Trp Gln Arg Cys Ile Glu 
        595                 600                 605             


Gly Thr Cys Val Cys Lys Leu Pro Tyr Gln Cys Pro Lys Asn Gly Thr 
    610                 615                 620                 


Ala Val Cys Ala Thr Asn Arg Arg Ser Phe Pro Thr Tyr Cys Gln Gln 
625                 630                 635                 640 


Lys Ser Leu Glu Cys Leu His Pro Gly Thr Lys Phe Leu Asn Asn Gly 
                645                 650                 655     


Thr Cys Thr Ala Glu Gly Lys Phe Ser Val Ser Leu Lys His Gly Asn 
            660                 665                 670         


Thr Asp Ser Glu Gly Ile Val Glu Val Lys Leu Val Asp Gln Asp Lys 
        675                 680                 685             


Thr Met Phe Ile Cys Lys Ser Ser Trp Ser Met Arg Glu Ala Asn Val 
    690                 695                 700                 


Ala Cys Leu Asp Leu Gly Phe Gln Gln Gly Ala Asp Thr Gln Arg Arg 
705                 710                 715                 720 


Phe Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr Glu Cys Leu His Val 
                725                 730                 735     


His Cys Arg Gly Leu Glu Thr Ser Leu Ala Glu Cys Thr Phe Thr Lys 
            740                 745                 750         


Arg Arg Thr Met Gly Tyr Gln Asp Phe Ala Asp Val Val Cys Tyr Thr 
        755                 760                 765             


Gln Lys Ala Asp Ser Pro Met Asp Asp Phe Phe Gln Cys Val Asn Gly 
    770                 775                 780                 


Lys Tyr Ile Ser Gln Met Lys Ala Cys Asp Gly Ile Asn Asp Cys Gly 
785                 790                 795                 800 


Asp Gln Ser Asp Glu Leu Cys Cys Lys Ala Cys Gln Gly Lys Gly Phe 
                805                 810                 815     


His Cys Lys Ser Gly Val Cys Ile Pro Ser Gln Tyr Gln Cys Asn Gly 
            820                 825                 830         


Glu Val Asp Cys Ile Thr Gly Glu Asp Glu Val Gly Cys Ala Gly Phe 
        835                 840                 845             


Ala Ser Val Thr Gln Glu Glu Thr Glu Ile Leu Thr Ala Asp Met Asp 
    850                 855                 860                 


Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Cys Gly 
865                 870                 875                 880 


Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly Lys 
                885                 890                 895     


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
            900                 905                 910         


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
        915                 920                 925             


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
    930                 935                 940                 


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
945                 950                 955                 960 


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
                965                 970                 975     


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
            980                 985                 990         


Lys Lys Asp Cys Glu Leu Pro Arg  Ser Ile Pro Ala Cys  Val Pro Trp 
        995                 1000                 1005             


Ser Pro  Tyr Leu Phe Gln Pro  Asn Asp Thr Cys Ile  Val Ser Gly 
    1010                 1015                 1020             


Trp Gly  Arg Glu Lys Asp Asn  Glu Arg Val Phe Ser  Leu Gln Trp 
    1025                 1030                 1035             


Gly Glu  Val Lys Leu Ile Ser  Asn Cys Ser Lys Phe  Tyr Gly Asn 
    1040                 1045                 1050             


Arg Phe  Tyr Glu Lys Glu Met  Glu Cys Ala Gly Thr  Tyr Asp Gly 
    1055                 1060                 1065             


Ser Ile  Asp Ala Cys Lys Gly  Asp Ser Gly Gly Pro  Leu Val Cys 
    1070                 1075                 1080             


Met Asp  Ala Asn Asn Val Thr  Tyr Val Trp Gly Val  Val Ser Trp 
    1085                 1090                 1095             


Gly Glu  Asn Cys Gly Lys Pro  Glu Phe Pro Gly Val  Tyr Thr Lys 
    1100                 1105                 1110             


Val Ala  Asn Tyr Phe Asp Trp  Ile Ser Tyr His Val  Gly Arg Pro 
    1115                 1120                 1125             


Phe Ile  Ser Gln Tyr Asn Val  
    1130                 1135 


<210>  17
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  17

Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly Lys 
1               5                   10                  15      


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
            20                  25                  30          


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
        35                  40                  45              


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
    50                  55                  60                  


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
65                  70                  75                  80  


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
                85                  90                  95      


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
            100                 105                 110         


Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Cys Val Pro Trp 
        115                 120                 125             


Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp 
    130                 135                 140                 


Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu 
145                 150                 155                 160 


Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
                165                 170                 175     


Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala 
            180                 185                 190         


Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn 
        195                 200                 205             


Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys 
    210                 215                 220                 


Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp 
225                 230                 235                 240 


Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Val Thr Tyr Thr Ser Gln 
            260                 265                 270         


Glu Asp Leu Val Glu Lys Lys Cys Leu Ala Lys Lys Tyr Thr His Leu 
        275                 280                 285             


Ser Cys Asp Lys Val Phe Cys Gln Pro Trp Gln Arg Cys Ile Glu Gly 
    290                 295                 300                 


Thr Cys Val Cys Lys Leu Pro Tyr Gln Cys Pro Lys Asn Gly Thr Ala 
305                 310                 315                 320 


Val Cys Ala Thr Asn Arg Arg Ser Phe Pro Thr Tyr Cys Gln Gln Lys 
                325                 330                 335     


Ser Leu Glu Cys Leu His Pro Gly Thr Lys Phe Leu Asn Asn Gly Thr 
            340                 345                 350         


Cys Thr Ala Glu Gly Lys Phe Ser Val Ser Leu Lys His Gly Asn Thr 
        355                 360                 365             


Asp Ser Glu Gly Ile Val Glu Val Lys Leu Val Asp Gln Asp Lys Thr 
    370                 375                 380                 


Met Phe Ile Cys Lys Ser Ser Trp Ser Met Arg Glu Ala Asn Val Ala 
385                 390                 395                 400 


Cys Leu Asp Leu Gly Phe Gln Gln Gly Ala Asp Thr Gln Arg Arg Phe 
                405                 410                 415     


Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr Glu Cys Leu His Val His 
            420                 425                 430         


Cys Arg Gly Leu Glu Thr Ser Leu Ala Glu Cys Thr Phe Thr Lys Arg 
        435                 440                 445             


Arg Thr Met Gly Tyr Gln Asp Phe Ala Asp Val Val Cys Tyr Thr Gln 
    450                 455                 460                 


Lys Ala Asp Ser Pro Met Asp Asp Phe Phe Gln Cys Val Asn Gly Lys 
465                 470                 475                 480 


Tyr Ile Ser Gln Met Lys Ala Cys Asp Gly Ile Asn Asp Cys Gly Asp 
                485                 490                 495     


Gln Ser Asp Glu Leu Cys Cys Lys Ala Cys Gln Gly Lys Gly Phe His 
            500                 505                 510         


Cys Lys Ser Gly Val Cys Ile Pro Ser Gln Tyr Gln Cys Asn Gly Glu 
        515                 520                 525             


Val Asp Cys Ile Thr Gly Glu Asp Glu Val Gly Cys Ala Gly Phe Ala 
    530                 535                 540                 


Ser Val Thr Gln Glu Glu Thr Glu Ile Leu Thr Ala Asp Met Asp Ala 
545                 550                 555                 560 


Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Cys Gly 
                565                 570                 575 


<210>  18
<211>  578
<212>  PRT
<213>  Homo Sapiens

<400>  18

Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly Lys 
1               5                   10                  15      


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
            20                  25                  30          


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
        35                  40                  45              


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
    50                  55                  60                  


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
65                  70                  75                  80  


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
                85                  90                  95      


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
            100                 105                 110         


Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Cys Val Pro Trp 
        115                 120                 125             


Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp 
    130                 135                 140                 


Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu 
145                 150                 155                 160 


Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
                165                 170                 175     


Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala 
            180                 185                 190         


Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn 
        195                 200                 205             


Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys 
    210                 215                 220                 


Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp 
225                 230                 235                 240 


Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Val Thr Tyr 
            260                 265                 270         


Thr Ser Gln Glu Asp Leu Val Glu Lys Lys Cys Leu Ala Lys Lys Tyr 
        275                 280                 285             


Thr His Leu Ser Cys Asp Lys Val Phe Cys Gln Pro Trp Gln Arg Cys 
    290                 295                 300                 


Ile Glu Gly Thr Cys Val Cys Lys Leu Pro Tyr Gln Cys Pro Lys Asn 
305                 310                 315                 320 


Gly Thr Ala Val Cys Ala Thr Asn Arg Arg Ser Phe Pro Thr Tyr Cys 
                325                 330                 335     


Gln Gln Lys Ser Leu Glu Cys Leu His Pro Gly Thr Lys Phe Leu Asn 
            340                 345                 350         


Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe Ser Val Ser Leu Lys His 
        355                 360                 365             


Gly Asn Thr Asp Ser Glu Gly Ile Val Glu Val Lys Leu Val Asp Gln 
    370                 375                 380                 


Asp Lys Thr Met Phe Ile Cys Lys Ser Ser Trp Ser Met Arg Glu Ala 
385                 390                 395                 400 


Asn Val Ala Cys Leu Asp Leu Gly Phe Gln Gln Gly Ala Asp Thr Gln 
                405                 410                 415     


Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr Glu Cys Leu 
            420                 425                 430         


His Val His Cys Arg Gly Leu Glu Thr Ser Leu Ala Glu Cys Thr Phe 
        435                 440                 445             


Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp Phe Ala Asp Val Val Cys 
    450                 455                 460                 


Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp Asp Phe Phe Gln Cys Val 
465                 470                 475                 480 


Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala Cys Asp Gly Ile Asn Asp 
                485                 490                 495     


Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys Lys Ala Cys Gln Gly Lys 
            500                 505                 510         


Gly Phe His Cys Lys Ser Gly Val Cys Ile Pro Ser Gln Tyr Gln Cys 
        515                 520                 525             


Asn Gly Glu Val Asp Cys Ile Thr Gly Glu Asp Glu Val Gly Cys Ala 
    530                 535                 540                 


Gly Phe Ala Ser Val Thr Gln Glu Glu Thr Glu Ile Leu Thr Ala Asp 
545                 550                 555                 560 


Met Asp Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser 
                565                 570                 575     


Cys Gly 
        


<210>  19
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  19

Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly Lys 
1               5                   10                  15      


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
            20                  25                  30          


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
        35                  40                  45              


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
    50                  55                  60                  


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
65                  70                  75                  80  


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
                85                  90                  95      


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
            100                 105                 110         


Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ser Val Pro Trp 
        115                 120                 125             


Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp 
    130                 135                 140                 


Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu 
145                 150                 155                 160 


Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
                165                 170                 175     


Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala 
            180                 185                 190         


Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn 
        195                 200                 205             


Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys 
    210                 215                 220                 


Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp 
225                 230                 235                 240 


Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Val Thr Tyr Thr Ser Gln 
            260                 265                 270         


Glu Asp Leu Val Glu Lys Lys Cys Leu Ala Lys Lys Tyr Thr His Leu 
        275                 280                 285             


Ser Cys Asp Lys Val Phe Cys Gln Pro Trp Gln Arg Cys Ile Glu Gly 
    290                 295                 300                 


Thr Cys Val Cys Lys Leu Pro Tyr Gln Cys Pro Lys Asn Gly Thr Ala 
305                 310                 315                 320 


Val Cys Ala Thr Asn Arg Arg Ser Phe Pro Thr Tyr Cys Gln Gln Lys 
                325                 330                 335     


Ser Leu Glu Cys Leu His Pro Gly Thr Lys Phe Leu Asn Asn Gly Thr 
            340                 345                 350         


Cys Thr Ala Glu Gly Lys Phe Ser Val Ser Leu Lys His Gly Asn Thr 
        355                 360                 365             


Asp Ser Glu Gly Ile Val Glu Val Lys Leu Val Asp Gln Asp Lys Thr 
    370                 375                 380                 


Met Phe Ile Cys Lys Ser Ser Trp Ser Met Arg Glu Ala Asn Val Ala 
385                 390                 395                 400 


Cys Leu Asp Leu Gly Phe Gln Gln Gly Ala Asp Thr Gln Arg Arg Phe 
                405                 410                 415     


Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr Glu Cys Leu His Val His 
            420                 425                 430         


Cys Arg Gly Leu Glu Thr Ser Leu Ala Glu Cys Thr Phe Thr Lys Arg 
        435                 440                 445             


Arg Thr Met Gly Tyr Gln Asp Phe Ala Asp Val Val Cys Tyr Thr Gln 
    450                 455                 460                 


Lys Ala Asp Ser Pro Met Asp Asp Phe Phe Gln Cys Val Asn Gly Lys 
465                 470                 475                 480 


Tyr Ile Ser Gln Met Lys Ala Cys Asp Gly Ile Asn Asp Cys Gly Asp 
                485                 490                 495     


Gln Ser Asp Glu Leu Cys Cys Lys Ala Cys Gln Gly Lys Gly Phe His 
            500                 505                 510         


Cys Lys Ser Gly Val Cys Ile Pro Ser Gln Tyr Gln Cys Asn Gly Glu 
        515                 520                 525             


Val Asp Cys Ile Thr Gly Glu Asp Glu Val Gly Cys Ala Gly Phe Ala 
    530                 535                 540                 


Ser Val Thr Gln Glu Glu Thr Glu Ile Leu Thr Ala Asp Met Asp Ala 
545                 550                 555                 560 


Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Ser Gly 
                565                 570                 575 


<210>  20
<211>  578
<212>  PRT
<213>  Homo Sapiens

<400>  20

Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly Lys 
1               5                   10                  15      


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
            20                  25                  30          


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
        35                  40                  45              


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
    50                  55                  60                  


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
65                  70                  75                  80  


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
                85                  90                  95      


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
            100                 105                 110         


Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Ser Val Pro Trp 
        115                 120                 125             


Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp 
    130                 135                 140                 


Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu 
145                 150                 155                 160 


Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
                165                 170                 175     


Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala 
            180                 185                 190         


Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn 
        195                 200                 205             


Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys 
    210                 215                 220                 


Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp 
225                 230                 235                 240 


Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Val Thr Tyr 
            260                 265                 270         


Thr Ser Gln Glu Asp Leu Val Glu Lys Lys Cys Leu Ala Lys Lys Tyr 
        275                 280                 285             


Thr His Leu Ser Cys Asp Lys Val Phe Cys Gln Pro Trp Gln Arg Cys 
    290                 295                 300                 


Ile Glu Gly Thr Cys Val Cys Lys Leu Pro Tyr Gln Cys Pro Lys Asn 
305                 310                 315                 320 


Gly Thr Ala Val Cys Ala Thr Asn Arg Arg Ser Phe Pro Thr Tyr Cys 
                325                 330                 335     


Gln Gln Lys Ser Leu Glu Cys Leu His Pro Gly Thr Lys Phe Leu Asn 
            340                 345                 350         


Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe Ser Val Ser Leu Lys His 
        355                 360                 365             


Gly Asn Thr Asp Ser Glu Gly Ile Val Glu Val Lys Leu Val Asp Gln 
    370                 375                 380                 


Asp Lys Thr Met Phe Ile Cys Lys Ser Ser Trp Ser Met Arg Glu Ala 
385                 390                 395                 400 


Asn Val Ala Cys Leu Asp Leu Gly Phe Gln Gln Gly Ala Asp Thr Gln 
                405                 410                 415     


Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr Glu Cys Leu 
            420                 425                 430         


His Val His Cys Arg Gly Leu Glu Thr Ser Leu Ala Glu Cys Thr Phe 
        435                 440                 445             


Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp Phe Ala Asp Val Val Cys 
    450                 455                 460                 


Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp Asp Phe Phe Gln Cys Val 
465                 470                 475                 480 


Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala Cys Asp Gly Ile Asn Asp 
                485                 490                 495     


Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys Lys Ala Cys Gln Gly Lys 
            500                 505                 510         


Gly Phe His Cys Lys Ser Gly Val Cys Ile Pro Ser Gln Tyr Gln Cys 
        515                 520                 525             


Asn Gly Glu Val Asp Cys Ile Thr Gly Glu Asp Glu Val Gly Cys Ala 
    530                 535                 540                 


Gly Phe Ala Ser Val Thr Gln Glu Glu Thr Glu Ile Leu Thr Ala Asp 
545                 550                 555                 560 


Met Asp Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser 
                565                 570                 575     


Ser Gly 
        


<210>  21
<211>  1156
<212>  PRT
<213>  Homo Sapiens

<400>  21

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Ser Gly Gly Lys 
            580                 585                 590         


Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys Cys Leu Ala 
        595                 600                 605             


Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys Gln Pro Trp 
    610                 615                 620                 


Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro Tyr Gln Cys 
625                 630                 635                 640 


Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg Ser Phe Pro 
                645                 650                 655     


Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro Gly Thr Lys 
            660                 665                 670         


Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe Ser Val Ser 
        675                 680                 685             


Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu Val Lys Leu 
    690                 695                 700                 


Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser Trp Ser Met 
705                 710                 715                 720 


Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln Gln Gly Ala 
                725                 730                 735     


Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr 
            740                 745                 750         


Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser Leu Ala Glu 
        755                 760                 765             


Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp Phe Ala Asp 
    770                 775                 780                 


Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp Asp Phe Phe 
785                 790                 795                 800 


Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala Cys Asp Gly 
                805                 810                 815     


Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys Lys Ala Cys 
            820                 825                 830         


Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile Pro Ser Gln 
        835                 840                 845             


Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu Asp Glu Val 
    850                 855                 860                 


Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr Glu Ile Leu 
865                 870                 875                 880 


Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro 
                885                 890                 895     


Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg Arg Lys Arg 
            900                 905                 910         


Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
        915                 920                 925             


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
    930                 935                 940                 


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
945                 950                 955                 960 


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
                965                 970                 975     


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
            980                 985                 990         


Asn Tyr Asn Ala Gly Thr Tyr Gln  Asn Asp Ile Ala Leu  Ile Glu Met 
        995                 1000                 1005             


Lys Lys  Asp Gly Asn Lys Lys  Asp Cys Glu Leu Pro  Arg Ser Ile 
    1010                 1015                 1020             


Pro Ala  Cys Val Pro Trp Ser  Pro Tyr Leu Phe Gln  Pro Asn Asp 
    1025                 1030                 1035             


Thr Cys  Ile Val Ser Gly Trp  Gly Arg Glu Lys Asp  Asn Glu Arg 
    1040                 1045                 1050             


Val Phe  Ser Leu Gln Trp Gly  Glu Val Lys Leu Ile  Ser Asn Cys 
    1055                 1060                 1065             


Ser Lys  Phe Tyr Gly Asn Arg  Phe Tyr Glu Lys Glu  Met Glu Cys 
    1070                 1075                 1080             


Ala Gly  Thr Tyr Asp Gly Ser  Ile Asp Ala Cys Lys  Gly Asp Ser 
    1085                 1090                 1095             


Gly Gly  Pro Leu Val Cys Met  Asp Ala Asn Asn Val  Thr Tyr Val 
    1100                 1105                 1110             


Trp Gly  Val Val Ser Trp Gly  Glu Asn Cys Gly Lys  Pro Glu Phe 
    1115                 1120                 1125             


Pro Gly  Val Tyr Thr Lys Val  Ala Asn Tyr Phe Asp  Trp Ile Ser 
    1130                 1135                 1140             


Tyr His  Val Gly Arg Pro Phe  Ile Ser Gln Tyr Asn  Val 
    1145                 1150                 1155     


<210>  22
<211>  1376
<212>  PRT
<213>  Homo Sapiens

<400>  22

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
            20                  25                  30          


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
        35                  40                  45              


Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn 
    50                  55                  60                  


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
65                  70                  75                  80  


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
                85                  90                  95      


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
            100                 105                 110         


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
        115                 120                 125             


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
    130                 135                 140                 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
145                 150                 155                 160 


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
                165                 170                 175     


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
            180                 185                 190         


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
        195                 200                 205             


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
    210                 215                 220                 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
225                 230                 235                 240 


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
                245                 250                 255     


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
            260                 265                 270         


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
        275                 280                 285             


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
305                 310                 315                 320 


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
                325                 330                 335     


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
            340                 345                 350         


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
        355                 360                 365             


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
    370                 375                 380                 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
385                 390                 395                 400 


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
                405                 410                 415     


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            420                 425                 430         


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        435                 440                 445             


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    450                 455                 460                 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
465                 470                 475                 480 


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                485                 490                 495     


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            500                 505                 510         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        515                 520                 525             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    530                 535                 540                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
545                 550                 555                 560 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                565                 570                 575     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            580                 585                 590         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser 
        595                 600                 605             


Ser Gly Gly Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys 
    610                 615                 620                 


Lys Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe 
625                 630                 635                 640 


Cys Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu 
                645                 650                 655     


Pro Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg 
            660                 665                 670         


Arg Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His 
        675                 680                 685             


Pro Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys 
    690                 695                 700                 


Phe Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val 
705                 710                 715                 720 


Glu Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser 
                725                 730                 735     


Ser Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe 
            740                 745                 750         


Gln Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser 
        755                 760                 765             


Ile Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr 
    770                 775                 780                 


Ser Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln 
785                 790                 795                 800 


Asp Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met 
                805                 810                 815     


Asp Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys 
            820                 825                 830         


Ala Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys 
        835                 840                 845             


Cys Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys 
    850                 855                 860                 


Ile Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly 
865                 870                 875                 880 


Glu Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu 
                885                 890                 895     


Thr Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys 
            900                 905                 910         


Ser Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile 
        915                 920                 925             


Arg Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu 
    930                 935                 940                 


Pro Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly 
945                 950                 955                 960 


Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg 
                965                 970                 975     


Ala Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp 
            980                 985                 990         


Ile His Pro Asp Leu Lys Arg Ile  Val Ile Glu Tyr Val  Asp Arg Ile 
        995                 1000                 1005             


Ile Phe  His Glu Asn Tyr Asn  Ala Gly Thr Tyr Gln  Asn Asp Ile 
    1010                 1015                 1020             


Ala Leu  Ile Glu Met Lys Lys  Asp Gly Asn Lys Lys  Asp Cys Glu 
    1025                 1030                 1035             


Leu Pro  Arg Ser Ile Pro Ala  Cys Val Pro Trp Ser  Pro Tyr Leu 
    1040                 1045                 1050             


Phe Gln  Pro Asn Asp Thr Cys  Ile Val Ser Gly Trp  Gly Arg Glu 
    1055                 1060                 1065             


Lys Asp  Asn Glu Arg Val Phe  Ser Leu Gln Trp Gly  Glu Val Lys 
    1070                 1075                 1080             


Leu Ile  Ser Asn Cys Ser Lys  Phe Tyr Gly Asn Arg  Phe Tyr Glu 
    1085                 1090                 1095             


Lys Glu  Met Glu Cys Ala Gly  Thr Tyr Asp Gly Ser  Ile Asp Ala 
    1100                 1105                 1110             


Cys Lys  Gly Asp Ser Gly Gly  Pro Leu Val Cys Met  Asp Ala Asn 
    1115                 1120                 1125             


Asn Val  Thr Tyr Val Trp Gly  Val Val Ser Trp Gly  Glu Asn Cys 
    1130                 1135                 1140             


Gly Lys  Pro Glu Phe Pro Gly  Val Tyr Thr Lys Val  Ala Asn Tyr 
    1145                 1150                 1155             


Phe Asp  Trp Ile Ser Tyr His  Val Gly Arg Pro Phe  Ile Ser Gln 
    1160                 1165                 1170             


Tyr Asn  Val Gly Gly Ser Ser  Gly Gly Gly His Cys  Gln Ala Pro 
    1175                 1180                 1185             


Asp His  Phe Leu Phe Ala Lys  Leu Lys Thr Gln Thr  Asn Ala Ser 
    1190                 1195                 1200             


Asp Phe  Pro Ile Gly Thr Ser  Leu Lys Tyr Glu Cys  Arg Pro Glu 
    1205                 1210                 1215             


Tyr Tyr  Gly Arg Pro Phe Ser  Ile Thr Cys Leu Asp  Asn Leu Val 
    1220                 1225                 1230             


Trp Ser  Ser Pro Lys Asp Val  Cys Lys Arg Lys Ser  Cys Lys Thr 
    1235                 1240                 1245             


Pro Pro  Asp Pro Val Asn Gly  Met Val His Val Ile  Thr Asp Ile 
    1250                 1255                 1260             


Gln Val  Gly Ser Arg Ile Asn  Tyr Ser Cys Thr Thr  Gly His Arg 
    1265                 1270                 1275             


Leu Ile  Gly His Ser Ser Ala  Glu Cys Ile Leu Ser  Gly Asn Ala 
    1280                 1285                 1290             


Ala His  Trp Ser Thr Lys Pro  Pro Ile Cys Gln Arg  Ile Pro Cys 
    1295                 1300                 1305             


Gly Leu  Pro Pro Thr Ile Ala  Asn Gly Asp Phe Ile  Ser Thr Asn 
    1310                 1315                 1320             


Arg Glu  Asn Phe His Tyr Gly  Ser Val Val Thr Tyr  Arg Cys Asn 
    1325                 1330                 1335             


Pro Gly  Ser Gly Gly Arg Lys  Val Phe Glu Leu Val  Gly Glu Pro 
    1340                 1345                 1350             


Ser Ile  Tyr Cys Thr Ser Asn  Asp Asp Gln Val Gly  Ile Trp Ser 
    1355                 1360                 1365             


Gly Pro  Ala Pro Gln Cys Ile  Ile 
    1370                 1375     


<210>  23
<211>  603
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Lys Leu Ala His Leu Ser Leu Phe Leu Leu Ala Leu His Leu Ser 
1               5                   10                  15      


Ser Ser Arg Ser Pro Ser Ala Ser Asp Leu Pro Gln Glu Glu Leu Val 
            20                  25                  30          


Asp Gln Lys Cys Leu Leu Gln Lys Tyr Thr His Arg Ser Cys Asn Lys 
        35                  40                  45              


Val Phe Cys Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Ile Cys 
    50                  55                  60                  


Lys Leu Pro Tyr Gln Cys Pro Arg Ala Gly Thr Pro Val Cys Ala Met 
65                  70                  75                  80  


Asn Gly Arg Ser Tyr Pro Thr Tyr Cys His Gln Lys Ser Phe Glu Cys 
                85                  90                  95      


Leu His Pro Glu Ile Lys Phe Ser His Asn Gly Thr Cys Ala Ala Glu 
            100                 105                 110         


Gly Lys Phe Asn Val Ser Leu Ile Tyr Gly Arg Thr Lys Thr Glu Gly 
        115                 120                 125             


Leu Val Gln Val Lys Leu Val Asp Gln Asp Glu Arg Met Phe Ile Cys 
    130                 135                 140                 


Lys Asn Ser Trp Ser Met Ala Glu Ala Asn Val Ala Cys Val Asp Leu 
145                 150                 155                 160 


Gly Phe Pro Leu Gly Val Arg Asp Ile Gln Gly Ser Phe Asn Ile Ser 
                165                 170                 175     


Gly Asn Leu His Ile Asn Asp Thr Glu Cys Leu His Val His Cys Arg 
            180                 185                 190         


Gly Val Glu Thr Ser Leu Ala Glu Cys Ala Phe Thr Lys Arg Arg Thr 
        195                 200                 205             


Glu Leu Ser Asn Gly Leu Ala Gly Val Val Cys Tyr Lys Gln Asp Ala 
    210                 215                 220                 


Asp Phe Pro Thr Ser Leu Ser Phe Gln Cys Val Asn Gly Lys His Ile 
225                 230                 235                 240 


Pro Gln Glu Lys Ala Cys Asn Gly Val Asn Asp Cys Gly Asp Gln Ser 
                245                 250                 255     


Asp Glu Leu Cys Cys Lys Gly Cys Arg Gly Asn Ala Ser Leu Cys Lys 
            260                 265                 270         


Ser Gly Val Cys Ile Pro Asp Gln Tyr Lys Cys Asn Gly Glu Val Asp 
        275                 280                 285             


Cys Ile Thr Gly Glu Asp Glu Ser Arg Cys Glu Glu Asp Arg Gln Gln 
    290                 295                 300                 


Asn Ile Pro Lys Gly Leu Ala Arg Ser Ala Gln Gly Glu Ala Glu Ile 
305                 310                 315                 320 


Glu Thr Glu Glu Thr Glu Met Leu Thr Pro Gly Met Asp Asn Glu Arg 
                325                 330                 335     


Lys Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Arg 
            340                 345                 350         


Asn Thr His Thr Arg Arg Lys Arg Val Ile Gly Gly Lys Pro Ala Asn 
        355                 360                 365             


Val Gly Asp Tyr Pro Trp Gln Val Ala Ile Lys Asp Gly Gln Arg Ile 
    370                 375                 380                 


Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala 
385                 390                 395                 400 


His Cys Val Arg Pro Ser Arg Ala His Ser Tyr Gln Val Trp Thr Ala 
                405                 410                 415     


Leu Leu Asp Trp Leu Lys Pro Asn Ser Gln Leu Gly Ile Gln Thr Val 
            420                 425                 430         


Lys Arg Val Ile Val His Glu Lys Tyr Asn Gly Ala Thr Phe Gln Asn 
        435                 440                 445             


Asp Ile Ala Leu Ile Glu Met Lys Met His Thr Gly Lys Lys Glu Cys 
    450                 455                 460                 


Glu Leu Pro Asn Ser Val Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu 
465                 470                 475                 480 


Phe Gln Pro Asn Asp Arg Cys Ile Ile Ser Gly Trp Gly Arg Gly Lys 
                485                 490                 495     


Asp Asn Gln Lys Val Tyr Ser Leu Arg Trp Gly Glu Val Asp Leu Ile 
            500                 505                 510         


Gly Asn Cys Ser Gln Phe Tyr Pro Asp Arg Tyr Tyr Glu Lys Glu Met 
        515                 520                 525             


Gln Cys Ala Gly Thr Arg Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp 
    530                 535                 540                 


Ser Gly Gly Pro Leu Val Cys Glu Asp Ile Asn Asn Val Thr Tyr Val 
545                 550                 555                 560 


Trp Gly Ile Val Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro 
                565                 570                 575     


Gly Val Tyr Thr Arg Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His 
            580                 585                 590         


Val Gly Arg Ser Leu Val Ser Gln His Asn Val 
        595                 600             


<210>  24
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  24

Glu Asp Val Pro Ala Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Asp 
1               5                   10                  15      


Ser Glu Thr Arg 
            20  


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  25

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10          


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  26

Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
1               5                   10  


<210>  27
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  27

Arg Pro Phe Ile Ser Gln Tyr Asn Val 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  28

Ser Glu Glu Thr Lys Gln Asn Glu Gly Phe 
1               5                   10  


